CN110338902A - Sacculus and medical system - Google Patents
Sacculus and medical system Download PDFInfo
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- CN110338902A CN110338902A CN201910729480.8A CN201910729480A CN110338902A CN 110338902 A CN110338902 A CN 110338902A CN 201910729480 A CN201910729480 A CN 201910729480A CN 110338902 A CN110338902 A CN 110338902A
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- 238000002844 melting Methods 0.000 claims description 55
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
- A61B2018/0022—Balloons
- A61B2018/0025—Multiple balloons
- A61B2018/00255—Multiple balloons arranged one inside another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00375—Ostium, e.g. ostium of pulmonary vein or artery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Hematology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
Disclose sacculus comprising: the first sacculus;Around the second sacculus of first sacculus arrangement;And the sacculus layer on second sacculus or on the outside of first sacculus is discontinuously set.
Description
Field
The disclosure relates generally to medical field.More specifically, this disclosure relates to medical field related with arrhythmia cordis.
Background
Heart is divided into left and right atrium and Ventricular.Sinoatrial node positioned at atrium dextrum top is regularly provided pulse and is referred to
It enables.Electric signal reaches entire heart by conducting system after of short duration delay occurs for atrioventricular node, and heart is made to generate synchronous coordination
It shrinks.The primary impulsion of the every generation of sinoatrial node, heart are just beated once, and " sinus rhythm " is medically known as.It is human normal
The rhythm of the heart, frequency is 60-100 times per minute.
However, to may be subjected to the irregular electric signal except sinoatrial node dry for normal electrical conduction system in heart
It disturbs, causes heartbeat to overrun, irregular bounce, and then developing is arrhythmia cordis.One of the most common type arrhythmia cordis is auricular fibrillation.
When morbidity, quick and irregular trembling can occur for patient atrium.Auricular fibrillation causes the risk that stroke occurs to increase by 500, extremely
The rate of dying increases 2 times, and the risk that heart failure occurs can also increase 3 times, greatly affected the health of patient.
It summarizes
On the one hand, this disclosure relates to sacculus comprising the first sacculus;Around the second sacculus of first sacculus arrangement;
And the sacculus layer on second sacculus or on the outside of first sacculus is discontinuously set.
In certain embodiments, sacculus layer has same stream comprising the liquid with thermal conductive resin or with the liquid
The solid fluid of dynamic property and thermal conductivity.
In certain embodiments, the liquid with thermal conductive resin is selected from mercury alloy or gallium alloy.
In certain embodiments, the freezing point of the solid with good fluidity is less than or equal to about -20 DEG C.
In certain embodiments, the freezing point of the solid with good fluidity is less than or equal to about -60 DEG C.
It in certain embodiments, is vacuum layer between the first sacculus and the second sacculus.
In certain embodiments, the compliance of sacculus layer is better than the compliance of the first sacculus and the second sacculus.
In certain embodiments, the composition of sacculus layer contains thermoplastic elastomer (TPE) (TPE), thermoplastic polyurethane elastomer
(TPU), or mixtures thereof polyurethane (PU).
In certain embodiments, sacculus further include: ontology;And be arranged in the ontology and from the ontology to
The axis that distal end extends.
In certain embodiments, discontinuous sacculus layer is located on the outside of the second sacculus.
In certain embodiments, discontinuous sacculus layer is located on the inside of the second sacculus.
In certain embodiments, discontinuous sacculus layer is located on the outside of the first sacculus.
In certain embodiments, rotating mechanism is provided on axis.
In certain embodiments, inner surface of the other end for the rotating mechanism being arranged on axis close to the first sacculus.
On the other hand, this disclosure relates to medical system comprising: freeze melting device;And it is filled with the cryoablation
The control unit of connection is set, wherein the freeze melting device includes sacculus, the sacculus includes the first sacculus;Around described
Second sacculus of one sacculus arrangement;And the sacculus on second sacculus or on the outside of first sacculus is discontinuously set
Layer.
In another aspect, this disclosure relates to implementing the side of pulmonary vein isolation (pulmonary vein isolation, PVI)
Method comprising: positioning freeze melting device, be allowed to and need the method individual heart orifices of pulmonary veins (pulmonary
Vein ostium, PVO) or the contact of Pulmonary venous vestibule (pulmonary vein antrum, PVA) tissue, and to described cold
Freeze in ablating device and inject coolant, wherein the freeze melting device includes sacculus, the sacculus includes the first sacculus;
Around the second sacculus of first sacculus arrangement;And discontinuously it is arranged on second sacculus or first sacculus
The sacculus layer in outside.
Brief Description Of Drawings
Fig. 1 shows the schematic diagram of the medical system including freeze melting device of the certain embodiments of the disclosure.
Fig. 2 shows the schematic diagrames of the medical system including freeze melting device of the certain embodiments of the disclosure.
Fig. 3 shows the schematic diagram of the medical system including freeze melting device of the certain embodiments of the disclosure.
Fig. 4 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Fig. 5 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Fig. 6 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Fig. 7 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Fig. 8 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Fig. 9 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 10 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 11 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 12 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 13 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 14 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 15 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 16 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 17 shows the sectional views of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 18 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 19 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 20 shows the sectional view of the distal end of the freeze melting device in the expanded state of the certain embodiments of the disclosure.
Figure 21 shows the partial enlarged view for the sacculus layer being arranged on the outside of the first sacculus in the certain embodiments of the disclosure.
Figure 22 shows the partial enlarged view for the sacculus layer being arranged on the inside of the second sacculus in the certain embodiments of the disclosure.
Figure 23 shows the freeze melting device in the non-expanded state positioned at atrium sinistrum of the certain embodiments of the disclosure
Schematic diagram.
Figure 24 shows the freeze melting device in the non-expanded state positioned at atrium sinistrum of the certain embodiments of the disclosure
Schematic diagram.
Figure 25 shows the freeze melting device in the expanded state positioned at atrium sinistrum of the certain embodiments of the disclosure
Schematic diagram.
Figure 26 shows the freeze melting device in the expanded state positioned at atrium sinistrum of the certain embodiments of the disclosure
Schematic diagram.
Figure 27 show the certain embodiments of the disclosure be located at atrium sinistrum contact with orifices of pulmonary veins and expand load under
Freeze melting device schematic diagram.
Figure 28 show the certain embodiments of the disclosure be located at atrium sinistrum contact with orifices of pulmonary veins and expand load under
Freeze melting device schematic diagram.
Figure 29 shows the dress of cryoablation in the expanded state for being mounted with rotating mechanism of the certain embodiments of the disclosure
The distal end schematic diagram set.
Figure 30 shows the schematic diagram of the rotating mechanism of the certain embodiments of the disclosure.
It is described in detail
In the following description, including certain concrete details are to provide comprehensive reason to each disclosed embodiment
Solution.However, those skilled in the relevant art are not, it will be recognized that use one or more of these concrete details, and use other
Embodiment is still realized in the case where method, component, material etc..
Unless required otherwise in the disclosure, in the whole instruction and appended claims, word " comprising ", " packet
Containing ", " containing " and " having " should be interpreted that meaning open, including formula, i.e., " including but not limited to ".
" embodiment " mentioned throughout the specification, " embodiment ", " in another embodiment " or " at certain
In a little embodiments " mean include in an at least embodiment to relevant specific reference element described in the embodiment,
Structure or feature.Therefore, throughout the specification different location occur phrase " in one embodiment " or " in embodiment
In " or " in another embodiment " or " in certain embodiments " same embodiment need not be all referred to.In addition, specifically wanting
Element, structure or feature can combine in one or more embodiments in any suitable manner.
Definition
In the disclosure, term " compliance ", which is meant, refers to the elastomer complexity that deformation occurs under external force.
Big its deformability of expression of the compliance of elastomer is strong, i.e., can cause biggish deformation under lesser external force.
In the disclosure, term " thermoplastic elastomer (TPE) (thermoplastic elastomer, TPE) " is meant under room temperature
Elasticity with rubber has the molding a kind of elastomer of plasticization under high temperature.
In the disclosure, term " thermoplastic polyurethane elastomer (thermoplastic polyurethanes, TPU) "
Mean (AB)nType block linear polymer, A are the polyester or polyethers of high molecular weight (1000 to 6000), and B is containing 2 to 12 straight chains
The glycol of carbon atom, chemical structure is diisocyanate between AB segment.
In the disclosure, term " polyurethane (polyurethane, PU) " contains carbamate in macromolecular main chain
The polymer of base.
In the disclosure, term " having thermal conductive resin " means that thermal conductivity is greater than 7W/ (mK).
In the disclosure, term " inside " means the side of nearly balloon lumen.
In the disclosure, term " outside " means the side of remote balloon lumen.
In the disclosure, term " pulmonary vein isolation (pulmonary vein isolation, PVI) " mean pulmonary vein and
Electricity block between atrium.
Specific embodiment
On the one hand, this disclosure relates to sacculus comprising the first sacculus;Around the second sacculus of first sacculus arrangement;
And the sacculus layer on second sacculus or on the outside of first sacculus is discontinuously set.
With reference to Fig. 1, sacculus 100 comprising the first sacculus 101 (internal layer sacculus), around the second of the first sacculus 101 arrangement
Sacculus 102 (outer layer sacculus), and the sacculus layer 103 in 102 outside of the second sacculus is discontinuously set.
With reference to Fig. 2, sacculus 200 comprising the first sacculus 201 (internal layer sacculus), around the second of the first sacculus 201 arrangement
Sacculus 202 (outer layer sacculus), and the sacculus layer 203 in 201 outside of the first sacculus is discontinuously set.
The arrangement of other component is similar or identical with sacculus 100 in sacculus 200.
With reference to Fig. 3, sacculus 300 comprising the first sacculus 301 (internal layer sacculus), around the second of the first sacculus 301 arrangement
Sacculus 302 (outer layer sacculus), and the sacculus layer 303 of 302 inside of the second sacculus is discontinuously set.
The arrangement of other component is similar or identical with sacculus 100 in sacculus 300.
It continues to refer to figure 1, is set as vacuum layer 104 between the first sacculus 101 and the second sacculus 102.In certain implementations
In scheme, setting vacuum layer 104 is primarily to whether detection 101 inside cold agent of the first sacculus leaks.
In certain embodiments, the liquid with thermal conductive resin is included in sacculus layer 103.In certain embodiments
In, the illustrative examples that can be used in the liquid of the disclosure include but is not limited to mercury alloy and gallium alloy.In certain embodiments
In, the freezing point that can be used in the liquid of the disclosure is less than or equal to about -20 DEG C.In certain embodiments, it can be used in this public affairs
The freezing point for the liquid opened is less than or equal to about -60 DEG C.
In certain embodiments, comprising having with aforementioned liquids with same mobility and thermally conductive in sacculus layer 103
The solid fluid of property.
The compliance of sacculus layer 103 is better than the compliance of the first sacculus 101 and the second sacculus 102.In certain embodiments
In, it can include but is not limited to thermoplastic elastomer (TPE) (TPE), heat as the illustrative examples of the material of the composition of sacculus layer 103
Plastic polyurethane elastomer (TPU) and polyurethane (PU).
In certain embodiments, can be used in the thermoplastic elastomer (TPE) (TPE) of the disclosure illustrative examples include but
It is not limited to phenylethylene (SBS, SIS, SEBS, SEPS), olefines (TPO, TPV), diene class (TPB, TPI), polyvinyl chloride-base
(TPVC, TCPE), urethane class (TPU), esters (TPEE), amides (TPAE), organic fluoride class (TPF), organic silicon and ethylene
Class.
In certain embodiments, it can be used in the illustrative examples of the thermoplastic polyurethane elastomer (TPU) of the disclosure
Including but not limited to polyester-type, polyether-type and butadiene-type.
It continues to refer to figure 1, sacculus 100 further includes ontology 105, and is arranged in ontology 105 and from ontology 105 to remote
Hold the axis 106 extended.
Axis 106 may include guidewire lumen 107, injection pipe 108, temperature sensor 109, draught line 110 and end 111.
In certain embodiments, guidewire lumen 107 can contribute to the injection of contrast agent to confirm that vein closure is good
It is good.
In certain embodiments, the illustrative examples that can be used in the contrast agent of the disclosure include but is not limited to iodine and sulphur
Sour barium.
In certain embodiments, guiding catheter can contribute to targeted vein by the seal wire that guidewire lumen 107 is put into.
In certain embodiments, coolant is dispersed by injection pipe 108 towards 101 inner surface of the first sacculus.
In certain embodiments, can be used in the coolant of the disclosure illustrative examples include but is not limited to liquid nitrogen and
Nitrous oxide.
In certain embodiments, temperature sensor 109 is used to monitor the temperature of the coolant of evaporation.
In certain embodiments, the illustrative examples that can be used in the temperature sensor of the disclosure include but is not limited to heat
Galvanic couple and thermal resistance.
Ontology 105 defines proximal part 120 and distal portions 130.
The proximal end 114 of the proximal end 112 of first sacculus 101 and distal end 113 and the second sacculus 102 and distally 115 can be with
Axis 106 or ontology 105 combine.
In certain embodiments, can be used in the proximal end 112 of the first sacculus 101 and distal end 113 and the second sacculus
The illustrative examples for the material that 102 proximal end 114 and distal end 115 are combined with axis 106 or ontology 105 include but is not limited to biofacies
The adhesive of appearance.
In certain embodiments, the illustrative examples that can be used in the biocompatible adhesive of the disclosure include but not
It is limited to the instant drying adhesive of medical grade.
In certain embodiments, the illustrative examples that can be used in the instant drying adhesive of the medical grade of the disclosure include but not
It is limited to the instant drying adhesive that ingredient contains epoxy resin.
In certain embodiments, as shown in figures 1 to 6, the distal portion of the proximal end 112 of the first sacculus 101 and ontology 105
130 are divided to combine, the distal end 113 of the first sacculus 101 is combined with end 111.
In the embodiment depicted in fig. 1, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment depicted in fig. 6, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, as shown in figs. 4 and 7, the proximal end 112 of the first sacculus 101 is close to the remote of ontology 105
It is combined at end part 130 with the proximal part 116 of axis 106, the distal end 113 of the first sacculus 101 is combined with end 111.
In the embodiment depicted in fig. 4, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment depicted in fig. 7, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, as shown in figs. 5 and 8, the proximal end 112 of the first sacculus 101 is in the distal portion with ontology 105
It is combined at a certain distance from dividing 130 to have with the proximal part 116 of axis 106, the distal end 113 of the first sacculus 101 is combined with end 111.
In the embodiment depicted in fig. 5, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment depicted in fig. 8, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, as shown in figs. 9 and 12, the distal end of the proximal end 112 of the first sacculus 101 and ontology 105
Part 130 combines, and the distal end 113 of the first sacculus 101 is combined in the distal portions 117 close at end 111 with axis 106.
In the embodiment depicted in fig. 9, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment depicted in fig. 12, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, as depicted in figure 10 and figure 13, the proximal end 112 of the first sacculus 101 is close to ontology 105
It is combined at distal portions 130 with the proximal part 116 of axis 106, the distal end 113 of the first sacculus 101 is close at end 111 and axis
106 distal portions 117 combine.
In the embodiment depicted in fig. 10, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment depicted in fig. 13, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, as shown in figures 11 and 14, the proximal end 112 of the first sacculus 101 is in the distal end with ontology 105
Part 130 is combined at a certain distance from having with the proximal part 116 of axis 106, and the distal end 113 of the first sacculus 101 is close to end 111
Place is combined with the distal portions 117 of axis 106.
In the embodiment depicted in fig. 11, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment depicted in fig. 14, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, as shown in figs. 15 and 18, the distal portion of the proximal end 112 of the first sacculus 101 and ontology 105
Points 130 combine, the distal end 113 of the first sacculus 101 at a certain distance from having with end 111 with 117 knot of distal portions of axis 106
It closes.
In the embodiment depicted in fig. 15, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment shown in Figure 18, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, as shown in figs. 16 and 19, the proximal end 112 of the first sacculus 101 is close to the remote of ontology 105
It is combined at end part 130 with the proximal part 116 of axis 106, there is being certain distance in the distal end 113 of the first sacculus 101 with end 111
Place is combined with the distal portions 117 of axis 106.
In the embodiment shown in Figure 16, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment shown in Figure 19, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, as shown in figs. 17 and 20, the proximal end 112 of the first sacculus 101 is in the distal end with ontology 105
Part 130 is combined at a certain distance from having with the proximal part 116 of axis 106, and the distal end 113 of the first sacculus 101 has with end 111
At a certain distance from combined with the distal portions 117 of axis 106.
In the embodiment shown in Figure 17, sacculus layer 103 is discontinuously set to the outside of the second sacculus 102.
In the embodiment shown in Figure 20, sacculus layer 103 is discontinuously set to the outside of the first sacculus 101.
In certain embodiments, the second balloon proximal and the set-up mode of distal end and the first balloon proximal and distal end are set
It is similar to set mode.
In certain embodiments, as shown in figures 1 to 6, the distal portion of the proximal end 114 of the second sacculus 102 and ontology 105
130 are divided to combine, the distal end 115 of the second sacculus 102 is combined with end 111.
In certain embodiments, the proximal end 114 of the second sacculus 102 is at the distal portions 130 close to ontology 105 and axis
106 proximal part 116 combines, and the distal end 115 of the second sacculus 102 is combined with end 111.
In certain embodiments, the proximal end 114 of the second sacculus 102 is having one with the distal portions 130 close to ontology 105
It is combined at set a distance with the proximal part 116 of axis 106, the distal end 115 of the second sacculus 102 is combined with end 111.
In certain embodiments, the proximal end 114 of the second sacculus 102 is combined with the distal portions 130 of ontology 105, and second
The distal end 115 of sacculus 102 is combined in the distal portions 117 close at end 111 with axis 106.
In certain embodiments, the proximal end 114 of the second sacculus 102 is at the distal portions 130 close to ontology 105 and axis
106 proximal part 116 combines, the distal end 115 of the second sacculus 102 close at end 111 with the distal portions 117 of axis 106
In conjunction with.
In certain embodiments, the proximal end 114 of the second sacculus 102 is having one with the distal portions 130 close to ontology 105
Combined at set a distance with the proximal part 116 of axis 106, the distal end 115 of the second sacculus 102 close at end 111 with axis 106
Distal portions 117 combine.
In certain embodiments, the proximal end 114 of the second sacculus 102 is combined with the distal portions 130 of ontology 105, and second
The distal end 115 of sacculus 102 is combined at a certain distance from having with end 111 with the distal portions 117 of axis 106.
In certain embodiments, the proximal end 114 of the second sacculus 102 is at the distal portions 130 close to ontology 105 and axis
106 proximal part 116 combines, and the distal end 115 of the second sacculus 102 is remote with axis 106 at a certain distance from having with end 111
End part 117 combines.
In certain embodiments, the proximal end 114 of the second sacculus 102 is having one with the distal portions 130 close to ontology 105
It is combined at set a distance with the proximal part 116 of axis 106, the distal end 115 of the second sacculus 102 has certain distance with end 111
Place is combined with the distal portions 117 of axis 106.
In certain embodiments, rotating mechanism 500 is provided on axis 106.
In certain embodiments, inner surface of the other end of the rotating mechanism 500 of the disclosure close to the first sacculus 101.
In certain embodiments, the rotating mechanism packet 500 that can be used in the disclosure includes universal joint 501,502 and of extension rod
End effector 503, wherein the extension rod is connect with the universal joint, and the end effector is mounted on the extension
One end of bar.
In certain embodiments, the universal joint 501 that can be used in the disclosure includes pedestal 504, cross axle 505 and universal
Section fork 506, wherein the cross axle 505 is installed on the pedestal 504, and the universal-joint fork 506 is installed on the cross
Axis 505.
In certain embodiments, the illustrative examples that can be used in the end effector of the disclosure include but is not limited to brush
Son.
In certain embodiments, the liquid or solid using the sacculus of the disclosure, when being bonded pulmonary vein, in sacculus layer
Poor part can be blocked from preferable be partially extruded to is blocked, so that enhancing the second sacculus (outer layer sacculus) is to pulmonary vein
The whole plugging effect of mouth improves success rate of operation.
In certain embodiments, the sacculus of the disclosure can be suitable for the irregular patient of orifices of pulmonary veins.
In certain embodiments, the vacuum layer in the sacculus of the disclosure can be used in detecting the first sacculus (inside sacculus)
Whether internal refrigerant leaks.
In certain embodiments, additional active force is capable of providing using the rotating mechanism of the disclosure, thus further
Enhance the second sacculus (outer layer sacculus) to the whole plugging effect of orifices of pulmonary veins.
On the other hand, this disclosure relates to medical system comprising: freeze melting device;And it is filled with the cryoablation
The control unit of connection is set, wherein the freeze melting device includes sacculus, the sacculus includes the first sacculus;Around described
Second sacculus of one sacculus arrangement;And the sacculus on second sacculus or on the outside of first sacculus is discontinuously set
Layer.
With reference to Fig. 1, medical system 500 may include freeze melting device 300 and be connected to freeze melting device 300
Control unit 400, wherein freeze melting device 300 includes sacculus 100, and sacculus 100 includes the first sacculus 100 (internal layer sacculus),
Around the second sacculus 102 (outer layer sacculus) of the first sacculus 101 arrangement, and 102 outside of the second sacculus is discontinuously set
Sacculus layer 103.
Freeze melting device 300 may include ontology 105 and one or more sacculus 100 or 200.
Ontology 105 defines proximal part 120 and distal portions 130.
The proximal part 120 of ontology 105 may include handle 140.In certain embodiments, handle 140 includes being used for
One or more knobs, lever, connector, cable or the other component of guidance, operation and control freeze melting device 300.
In certain embodiments, freeze melting device 300 can be connect by handle 140 with control unit 400.
In certain embodiments, control unit 400 may include first fluid feedway 401.
In certain embodiments, first fluid feedway 401 may include for holding the one of coolant or more
A container.
In certain embodiments, control unit 400 may include second fluid feedway 402.
In certain embodiments, second fluid feedway 402 may include one or more containers, and the container is used
In holding the non-cooled fluid for expanding the first sacculus.
In certain embodiments, control unit 400 may include control device 403.
In certain embodiments, the illustrative examples that can be used in the control device of the disclosure include but is not limited to pump.
In certain embodiments, control unit 400 may include one or more valves 404.
In certain embodiments, the illustrative examples that can be used in the valve of the disclosure include but is not limited to solenoid valve and electricity
Dynamic valve.
In certain embodiments, the illustrative examples that can be used in the solenoid valve of the disclosure include but is not limited to through type
Solenoid valve and proportional solenoid valve
In certain embodiments, it can be used in the sacculus in the freeze melting device 300 of the medical system 500 of the disclosure
It is also possible to the sacculus 200 or 300 of the disclosure.
In another aspect, this disclosure relates to implementing the side of pulmonary vein isolation (pulmonary vein isolation, PVI)
Method comprising: positioning freeze melting device, be allowed to and need the method individual heart orifices of pulmonary veins (pulmonary
Vein ostium, PVO) or the contact of Pulmonary venous vestibule (pulmonary vein antrum, PVA) tissue, and to described cold
Freeze in ablating device and inject coolant, wherein the freeze melting device includes sacculus, the sacculus includes the first sacculus;
Around the second sacculus of first sacculus arrangement;And discontinuously it is arranged on second sacculus or first sacculus
The sacculus layer in outside.
In certain embodiments, individual is mammal.
In certain embodiments, individual is the mankind.
In certain embodiments, freeze melting device is delivered to the atrium sinistrum (left atrium, LA) of individual.
In certain embodiments, the vascular system that sheath shape object (not shown) passes through individual is entered to the atrium dextrum of heart
(right atrium,RA)。
In certain embodiments, the illustrative examples that can be used in the vascular system of the disclosure include but is not limited to that stock is dynamic
Arteries and veins, arteria brachialis and radial artery.
In certain embodiments, when sheath shape object reaches in atrium dextrum, individual device (not shown) can be passed through
Sheath shape object, and it is used to pierce through the spacer film of atrium dextrum Yu atrium sinistrum.The device of puncture can be from the body of sheath shape object and individual
It is removed in body.
In certain embodiments, the freeze melting device 300 of the disclosure can pass through sheath shape object and enter atrium sinistrum.
In certain embodiments, as shown in Figure 23 or Figure 24, the freeze melting device 300 of the disclosure can be in sacculus
100 or 200 or 300 pass through the vascular system of individual in unexpanded situation and enter atrium sinistrum.
As shown in Figure 25 or Figure 26, once freeze melting device 300 is located in atrium sinistrum, and the of freeze melting device 300
One sacculus 101 or 201 301 can start to expand.
In certain embodiments, the can be made by discharging non-cooled fluid to the inner cavity of the first sacculus 101 or 201 or 301
One sacculus 101 or 201 or 301 expansions, so that the second sacculus 102 or 202 or 302 expansions.
In certain embodiments, the first fluid feedway 401 or second fluid that can star control unit 401 supply
To device 402, to discharge coolant or non-cooled fluid.
In certain embodiments, the disclosure this disclosure relates to implement pulmonary vein isolation (pulmonary vein
Isolation, PVI) method include that seal wire enters target vein, by the inflated in freeze melting device and positioning, to lung
Ostium venosum cordis is blocked, and coolant is injected into freeze melting device, to complete pulmonary vein isolation.
In certain embodiments, the closure situation of orifices of pulmonary veins is judged by injecting contrast agent.
In certain embodiments, in the case where orifices of pulmonary veins blocks good situation, cooling is injected into freeze melting device
Agent.
In certain embodiments, after completing pulmonary vein isolation, Deflation is simultaneously withdrawn into sheath shape object.
In the disclosure, relational terms such as first and second and the like be used merely to by an entity or operation with
Another entity or operation distinguish, and without necessarily requiring or implying between these entities or operation, there are any this realities
The relationship or sequence on border.
From the foregoing it is appreciated that although in order to which the purpose of exemplary illustration describes the specific embodiment of the disclosure,
But under conditions of without departing from spirit and scope of the present disclosure, technical staff described in this field can make various modifications or change
Into.These deformations or modification should all fall into disclosure scope of the appended claims.
Claims (10)
1. sacculus comprising:
First sacculus;
Around the second sacculus of first sacculus arrangement;And
Sacculus layer on second sacculus or on the outside of first sacculus is discontinuously set.
2. sacculus as described in claim 1, wherein the sacculus layer include liquid with thermal conductive resin or with the liquid
Body has the solid fluid of same mobility and thermal conductivity, and the liquid is preferably selected from mercury alloy or gallium alloy, the preferably described liquid
The freezing point of body is less than or equal to -20 DEG C, more preferably less than or equal to -60 DEG C.
3. sacculus as claimed in claim 1 or 2, wherein being vacuum layer between first sacculus and second sacculus.
4. the sacculus as described in any claim in claims 1 to 3, wherein the compliance of the sacculus layer is better than described the
The composition of the compliance of one sacculus and second sacculus, the preferably described sacculus layer contains thermoplastic elastomer (TPE) (TPE), thermoplasticity
Or mixtures thereof polyurethane elastomer (TPU), polyurethane (PU).
5. the sacculus as described in any claim in Claims 1-4, further include:
Ontology;And
The axis for being arranged in the ontology and extending from the ontology to distal end.
6. such as the sacculus of any claim in claim 1 to 5, wherein the discontinuous sacculus layer is located at second ball
On the outside of capsule.
7. the sacculus as described in any claim in claim 1 to 5, wherein the discontinuous sacculus layer is located at described the
On the inside of two sacculus.
8. the sacculus as described in any claim in claim 1 to 7, wherein rotating mechanism is provided on the axis, and
It is preferred that inner surface of the other end of the rotating mechanism close to first sacculus.
9. medical system comprising:
Freeze melting device;And
The control unit being connected to the freeze melting device,
Wherein the freeze melting device includes sacculus described in any claim in claim 1 to 8.
10. implementing the method for pulmonary vein isolation (pulmonary vein isolation, PVI) comprising:
Position freeze melting device, be allowed to and need the method individual heart orifices of pulmonary veins (pulmonary vein
Ostium, PVO) or the contact of Pulmonary venous vestibule (pulmonary vein antrum, PVA) tissue, and
Coolant is injected into the freeze melting device,
Wherein the freeze melting device includes sacculus described in any claim in claim 1 to 8.
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CN201910729480.8A CN110338902A (en) | 2019-08-08 | 2019-08-08 | Sacculus and medical system |
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CN201910729480.8A CN110338902A (en) | 2019-08-08 | 2019-08-08 | Sacculus and medical system |
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CN212037721U (en) * | 2019-08-08 | 2020-12-01 | 深圳北芯生命科技有限公司 | Balloon and medical system |
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US20110190751A1 (en) * | 2010-02-01 | 2011-08-04 | Boston Scientific Scimed, Inc. | Nested balloon cryotherapy |
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Address after: 518052 area E, 3 / F, Tingwei Industrial Park, 6 Liufang Road, Xin'an street, Bao'an District, Shenzhen City, Guangdong Province Applicant after: Shenzhen Beixin Life Technology Co.,Ltd. Address before: 518052 area E, 3 / F, Tingwei Industrial Park, 6 Liufang Road, Xin'an street, Bao'an District, Shenzhen City, Guangdong Province Applicant before: INSIGHT LIFETECH Co.,Ltd. (SHENZHEN ) |