CN110316474B - Isolated heart transfer box - Google Patents

Isolated heart transfer box Download PDF

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Publication number
CN110316474B
CN110316474B CN201910566765.4A CN201910566765A CN110316474B CN 110316474 B CN110316474 B CN 110316474B CN 201910566765 A CN201910566765 A CN 201910566765A CN 110316474 B CN110316474 B CN 110316474B
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shell
heart
temperature adjusting
fixing
temperature
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CN110316474A (en
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王寅
董念国
蒋蔚蔚
胡行健
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/10—Devices to locate articles in containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B65D77/0446—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid or semi-rigid and the outer container being of polygonal cross-section not formed by folding or erecting one or more blanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/22—Details
    • B65D77/24—Inserts or accessories added or incorporated during filling of containers
    • B65D77/26—Elements or devices for locating or protecting articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/30—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2577/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks, bags
    • B65D2577/04—Articles or materials enclosed in two or more containers disposed one within another
    • B65D2577/041—Details of two or more containers disposed one within another
    • B65D2577/042—Comprising several inner containers

Abstract

The invention discloses an in vitro heart transfer box, wherein a heart fixing shell is connected inside a current limiting shell, and the current limiting shell is detachably connected inside a temperature adjusting shell; the heart fixing shell is in the shape of the heart external structure and is in a net structure; the current-limiting shell is of a net structure; the temperature adjusting shell is internally provided with a temperature adjusting pipeline, so that the temperature adjusting pipeline has the temperature control function on media in the temperature adjusting shell. The problem of among the prior art, to the separation heart transportation in-process, it is not strong to its fixed action of location, lead to the separation heart to move about in the transport box easily, and then lead to the damage to the separation heart. This separation heart transport case through the fixed separation heart of heart set casing to through the fixed casing of heart, current-limiting shell and each other connection structure, and the connection structure between its current-limiting shell and the shell that adjusts the temperature to separation heart buffering guard action, avoid the separation heart to receive the damage, and then to the complete guard action of separation heart, guarantee that the life characteristic of separation heart does not receive the damage.

Description

Isolated heart transfer box
Technical Field
The invention relates to the technical field of structural design of medical equipment for heart treatment and transportation, in particular to an in-vitro heart transfer box.
Background
Heart transplantation is primarily a surgical grafting procedure for advanced congestive heart failure and severe coronary artery disease. Is an allogenic transplantation operation which takes out the human heart which is judged to be dead and successfully matched and implants the human heart into the chest cavity of a needed receptor. The recipient's native heart is removed or retained to support the donor heart. Heart transplantation is used as a treatment to save the life and improve the quality of life of patients with end-stage heart disease. However, in the prior art, the human heart, which has been judged to be brain dead and successfully matched, is not necessarily in the same region as the recipient, and in order to satisfy the transplant operation for the recipient, the heart needs to be completely removed and transported to the hospital where the recipient patient is located.
In the prior art, ex vivo heart containment is typically accomplished by a transfer device during transfer. However, the transfer device in the prior art does not have a special transfer device for the isolated heart, and the existing transfer device can only ensure that the isolated heart is in a set medium environment and cannot fix the isolated heart, so that the isolated heart is easily damaged in the transfer process, and the vitality of the isolated heart is reduced.
Therefore, the transfer device in the prior art cannot be specially arranged aiming at the isolated heart, the force for positioning and buffering the isolated heart is insufficient, the regulation and control on the medium environment of the isolated heart are simple, the isolated heart is easily damaged, the vitality of the isolated heart can be reduced, and the use of a transplanted receptor after the heart is transplanted is further influenced.
Disclosure of Invention
In view of the above, the main object of the present invention is to provide an isolated heart transfer box capable of preventing an isolated heart from being damaged, thereby completely protecting the isolated heart and ensuring that the life characteristics of the isolated heart are not damaged.
In order to achieve the purpose, the technical scheme of the invention is realized as follows:
an ex vivo cardiac transfer cassette comprising: a heart fixing shell, a current limiting shell and a temperature adjusting shell; the heart fixing shell is connected inside the current-limiting shell, and the current-limiting shell is detachably connected inside the temperature-adjusting shell.
In a preferred embodiment, the heart fixing shell is in the shape of an external heart structure, and the heart fixing shell is in a net structure.
In a preferred embodiment, the flow restricting housing is a mesh structure.
In a preferred embodiment, a temperature control line is provided inside the temperature control housing, so that the temperature control line has a temperature control effect on the medium inside the temperature control housing.
In a preferred embodiment, the heart fixation housing comprises: an upper stationary case and a lower stationary case; the upper fixing shell and the lower fixing shell can be detachably clamped, so that the isolated heart is limited and fixed in the heart fixing shell.
In a preferred embodiment, the upper and lower stationary shells are made of a flexible material.
In a preferred embodiment, the upper fixing shell and the lower fixing shell are provided with vein vessel spacing cavities at the upper sides thereof, wherein the vein vessel spacing cavities are adapted to the heart structure.
In a preferred embodiment, the upper end of the heart fixing shell is open, and a limit buckle is arranged on one side of the upper end of the heart fixing shell, which is adaptive to the position of the heart aorta.
In a preferred embodiment, the current limiting case includes: an upper flow-limiting shell and a lower flow-limiting shell; the upper current limiting shell and the lower current limiting shell are detachably clamped.
In a preferred embodiment, the flow-limiting casing is made of a hard material.
In a preferred embodiment, a plurality of buffer support rods are fixedly connected between the lower side of the lower fixed casing and the inner side of the lower current-limiting casing.
In a preferred embodiment, the method further comprises: a mount, the mount comprising: a buffer fixing rod and a fixing plate; the upper end and the lower end of the buffering fixing rod are respectively fixedly connected with the inner cavity of the temperature adjusting shell and the lower surface of the fixing plate, and the fixing plate is supported and fixed; at least two positioning holes are formed in the fixing plate, the bottom of the lower flow limiting shell is integrally formed or fixedly connected with at least two positioning protrusions corresponding to the positioning holes, and the positioning protrusions are suitable for being inserted into the positioning holes to fix the flow limiting shell.
In a preferred embodiment, the temperature-regulating housing comprises: the bottom of the temperature adjusting main body is similar to the bottom of the inner cavity of the heart fixing shell in structure, and the size of the bottom of the temperature adjusting main body is 2.5-3.5 times that of the inner cavity of the heart fixing shell; the upper end of the temperature adjusting main body is fixedly connected with the upper side of the connecting part; the temperature adjusting pipeline is arranged inside the temperature adjusting main body.
In a preferred embodiment, the temperature-regulating housing further comprises: a seal cap, the seal cap comprising: the sealing plug is fixedly connected with the lower side of the middle of the cover body, the lower side of the edge of the cover body is detachably connected with the upper side of the connecting part, and the sealing plug is connected with the upper side of the inner cavity of the connecting part in a sealing manner.
In a preferred embodiment, the method further comprises: the protective shell is fixedly connected to the outside of the temperature adjusting shell, and a box handle is connected to the outside of the protective shell; the protective housing bottom is equipped with the buffering supporting pad.
In a preferred embodiment, a control module, a positioning module and a power supply module are arranged inside the protective shell; a temperature detection sensor is arranged in the temperature adjusting shell; the information output ends of the temperature detection sensor, the positioning module and the power supply module are connected with the information input end of the control module; the positioning module transmits positioning information to the control module, and the control module transmits the positioning information to the terminal equipment through a wireless network; the information output end of the control module is connected with the temperature adjusting pipeline, the control module sends control information to the temperature adjusting module, and the temperature adjusting pipeline is controlled to heat or refrigerate the temperature adjusting shell; and the power output end of the power supply module is connected with the control module, the positioning module, the temperature detection sensor and the temperature adjusting pipeline.
In a preferred embodiment, the mesh size of the mesh structure of the heart fixation housing is larger than the mesh size of the mesh structure of the flow-limiting housing.
The isolated heart transfer box has the following beneficial effects:
according to the in-vitro heart transfer box, a heart fixing shell is connected inside a current limiting shell, and the current limiting shell is detachably connected inside a temperature adjusting shell; the heart fixing shell is in the shape of the heart external structure and is in a net structure; the current-limiting shell is of a net structure; the temperature adjusting shell is internally provided with a temperature adjusting pipeline, so that the temperature adjusting pipeline has the temperature control function on media in the temperature adjusting shell. The problem of among the prior art, to the separation heart transportation in-process, it is not strong to its fixed action of location, lead to the separation heart to move about in the transport box easily, and then lead to the damage to the separation heart. This separation heart transport case through the fixed separation heart of heart set casing to through the fixed casing of heart, current-limiting shell and each other connection structure, and the connection structure between its current-limiting shell and the shell that adjusts the temperature to separation heart buffering guard action, avoid the separation heart to receive the damage, and then to the complete guard action of separation heart, guarantee that the life characteristic of separation heart does not receive the damage.
Drawings
FIG. 1 is a cross-sectional view of an ex vivo cardiac transfer cassette according to one embodiment of the present disclosure;
FIG. 2 is a schematic structural view of the isolated heart transfer cassette of FIG. 1 shown without a section of the heart fixation shell according to one embodiment of the present disclosure;
FIG. 3 is a schematic structural view of the isolated heart transfer box of FIG. 1 without the flow-limiting shell and the mounting bracket being cut away, according to one embodiment of the present disclosure;
fig. 4 is a schematic structural diagram of an ex vivo cardiac transfer cassette according to one embodiment of the present disclosure.
[ description of main reference symbols ]
1. The heart fixing shell 11, the upper fixing shell 12, the lower fixing shell 13, the vein limiting cavity 14 and the limiting buckle;
2. a flow-limiting shell 21, an upper flow-limiting shell 22 and a lower flow-limiting shell;
3. a temperature adjusting shell 31, a connecting part 32 and a temperature adjusting main body;
4. a temperature adjusting pipeline 5 and a buffer supporting rod;
6. a fixing frame 61, a buffering fixing rod 62 and a fixing plate;
7. a sealing cover 71, a cover body 72 and a sealing plug;
8. a protective shell 81, a box handle 82 and a buffering supporting pad;
91. a pressure bar, 92, a pressure plate.
Detailed Description
The isolated heart transfer box of the present invention will be described in further detail below with reference to the accompanying drawings and embodiments of the present invention.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
The terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
For ease of description, spatially relative terms such as "above … …"),
"above … …", "on … …", "above", and the like, are used to describe one device or feature as it appears in the figures in relation to another device or feature in spatial position. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
As shown in fig. 1, 2, 3 and 4, the ex vivo cardiac transfer cassette comprises: the heart fixing shell 1 mainly has the function of limiting, fixing and protecting the heart and avoids the isolated heart from being damaged by external collision in the transferring process; the temperature control medium flow limiting function of the temperature control function of the isolated heart ensures that the temperature change of the environment where the isolated heart is located is stable, further ensures that the temperature control medium where the isolated heart is located flows stably, avoids the problems that the environment space is large and the turbulence phenomenon is easy to generate, and protects the flow limiting shell of the isolated heart; the temperature adjusting shell 3 is mainly used for adjusting the temperature of media in the transfer box and carrying the media.
Connect heart set casing 1 inside current-limiting shell 2 (one side is fixed, and the connection can be dismantled to one side, satisfies the entering heart set casing 1 that the separation heart can be smooth), and current-limiting shell 2 can be dismantled and connect inside 3 shells that adjust the temperature.
In order to ensure a more stable fixing effect of the heart fixing shell 1 on the heart and further reduce the damage effect on the isolated heart, the heart fixing shell 1 is in the shape of the heart external structure, and the heart fixing shell 1 is in a net structure; the grid-shaped structure further ensures that the surface of the isolated heart is positioned in more media, and the life performance of the isolated heart is ensured.
Of course, in order to achieve the flow restriction of the flow restricting housing 2 and to ensure the smooth passage of the medium through the flow restricting housing 2, the flow restricting housing 2 is also of a mesh structure.
In order to realize the temperature adjusting function of the temperature adjusting shell 3, a temperature adjusting pipeline 4 is arranged inside the temperature adjusting shell 3, so that the temperature adjusting pipeline 4 can control the temperature of a medium inside the temperature adjusting shell 3. So that the medium is tempered in the following sequence: the temperature control device comprises a first temperature adjusting shell 3 internal medium, a second flow limiting shell 2 internal medium and finally a temperature control function on an environment medium where an isolated heart inside the heart fixing shell 1 is located.
In order to facilitate further fixation of the isolated heart and to facilitate fixation inside the heart fixation housing 1, the heart fixation housing 1 comprises: an upper stationary case 11 and a lower stationary case 12; the upper fixing shell 11 and the lower fixing shell 12 are detachably clamped with each other, so that the isolated heart is limited and fixed in the heart fixing shell 1. Preferably, a plurality of buckles are arranged on the outer wall of the mutual junction of the upper fixing shell 11 and the lower fixing shell 12, and the upper fixing shell 11 and the lower fixing shell 12 are detachably clamped through the buckles. Further preferably, the buckle may be a connecting buckle extending out of the outer wall of the edge of the upper fixing shell 11, a protrusion is arranged on one side of the connecting buckle close to the lower fixing shell 12, a concave pit is arranged at a position adapted to the protrusion, and the protrusion is clamped into the concave pit, so that the upper fixing shell 11 and the lower fixing shell 12 are clamped. Simple structure connects simply, satisfies the fixed to the separation heart, has the cost of manufacture of avoiding the too complicated increase transfer box of structure.
In order to improve the fixing strength of the heart fixing shell 1 to the isolated heart and avoid the heart fixing shell 1 from scratching the isolated heart so as to damage the vitality of the isolated heart. The upper fixing shell 11 and the lower fixing shell 12 are both made of flexible materials. Further preferably, the upper fixing shell 11 and the lower fixing shell 12 are made of flexible resin materials and serve as base layers, and the surface of each base layer is coated with a Parylene coating material, so that the possibility of isolated heart allergy is reduced, and the health of the isolated heart is guaranteed.
In order to avoid damage to the isolated heart, in particular damage at the individual input or output vessels of the isolated heart. The upper sides of the upper fixing shell 11 and the lower fixing shell 12 are provided with vein vessel spacing cavities 13 which are adaptive to the vessel structure of the heart. The pulmonary vein on the lower side of the isolated heart is lower than other blood vessels, when the isolated heart is fixed in the heart fixing shell 1, the end part of the pulmonary vein is arranged in the vein blood vessel limiting cavity 13 of the heart fixing shell 1, and the fixing and protecting effects on the isolated heart are ensured.
In order to ensure that the medium can enter the heart fixing shell 1 more smoothly, the isolated heart can obtain sufficient nutrient supply through the medium, and the vitality of the isolated heart can be further ensured. The upper end of the heart fixing shell 1 is open.
Of course, in order to avoid the damage of the artery blood vessel of the isolated heart, the artery blood vessel of the isolated heart is fixed. A position-limiting buckle 14 is arranged at one side of the upper end of the heart fixing shell 1 and is adapted to the position of the heart aorta. The fixing effect on the heart aorta is realized by the opening and closing of the limit buckle 14, and preferably, the limit buckle 14 is a two-valve cylinder which can be opened and closed, and the heart aorta is fixed in the cylinder structure.
Further preferably, the stopper 14 and the vein vessel stopper cavity 13 may be of a closed structure or an open structure.
Of course, in order to conveniently fix the body heart inside the heart fixing case 1, the current limiting case 2 includes: an upper flow restricting casing 21 and a lower flow restricting casing 22. The upper current limiting shell 21 and the lower current limiting shell 22 are detachably connected together in a clamping manner. When the isolated heart needs to be transported and fixedly held in the transport box, the flow limiting shell 2 is detached from the inside of the temperature adjusting shell 3 and taken out, the upper flow limiting shell 22 and the upper fixing shell 11 are detached from the inside of the temperature adjusting shell 3, the isolated heart is placed in the lower fixing shell 12, and then the isolated heart is fixed in the heart fixing shell 1 through the upper fixing shell 11. Further, the entire heart fixing shell 1 is fixed inside the flow restricting shell 2 by the connection between the upper flow restricting shell 21 and the lower flow restricting shell 22. The isolated heart is guaranteed to be isolated from the temperature adjusting cavity of the temperature adjusting shell 3 through the current limiting shell 2, so that the isolated heart is guaranteed to be in a small environment change, and the adaptability of the isolated heart is improved.
Of course, in order to improve the fixing and damping effect of the flow-limiting housing 2, the flow-limiting housing 2 is also made of a hard material. Preferably, the current-limiting case 2 is made of a hard resin material as a base layer, and a Parylene coating is coated on the surface of the base layer.
In order to ensure the buffering performance of the heart fixing shell 1, the isolated heart not only can realize the buffering effect of the heart fixing shell 1, but also can ensure the buffering effect through the buffering effect between the heart fixing shell 1 and the current limiting shell 2. A plurality of buffer support rods 5 are fixedly connected between the lower side of the lower stationary casing 12 and the inner side of the lower restrictor casing 22. The buffering bracing piece 5 is flexible pole, can realize flexible and buckling in the certain interval, guarantees the cushioning effect to heart set casing 1, can satisfy the fixed action to heart set casing 1 again.
In order to facilitate the detachable connection of the current limiting case 2 and to ensure the fixing of the current limiting case 2. This transfer box still includes: a fixed frame 6. Preferably, the fixing frame 6 comprises: a buffer fixing rod 61 for buffering the flow restriction case 2 and a fixing plate 62 detachably coupled to the flow restriction case 2. The upper end and the lower end of the buffer fixing rod 61 are respectively fixedly connected with the inner cavity of the temperature adjusting shell 3 and the lower surface of the fixing plate 62, and the buffer fixing rod has the functions of supporting, buffering and fixing the fixing plate 62.
In order to further fix the current limiting shell 2, at least two positioning holes are formed in the fixing plate 62, at least two positioning protrusions 23 corresponding to the positioning holes are integrally formed or fixedly connected to the bottom of the lower current limiting shell 22, and the positioning protrusions 23 are adapted to be inserted into the positioning holes, so that the current limiting shell 2 is fixed. Preferably, the locating hole and the locating protrusion are correspondingly provided with 2-3 pieces of locating protrusions, so that the locating accuracy can be ensured, the defects of dislocation and unchanged installation caused by too many locating structures can be avoided, and the detachable connection of the current-limiting shell 2 is facilitated.
In order to facilitate the connection between the temperature adjusting shell 3 and other components, the integrity and the sealing performance of the whole transfer box are ensured. The temperature regulation case 3 includes: a connecting portion 31 that mainly functions as a connection with other components; and a temperature adjusting main body 32 which is provided with a temperature adjusting pipeline 4 and mainly used for adjusting temperature. In order to ensure the temperature control uniformity, in particular the temperature of the temperature control medium at the flow-limiting housing 2 is the same, and thus the temperature of the medium reaching the heart of the patient is more uniform. The bottom of the temperature adjusting body 32 is similar to the bottom of the inner cavity of the heart fixing shell 1.
In order to ensure the quantity of the medium, the whole transfer box volume can not be too large. The bottom size of the temperature adjusting body 32 is 2.5-3.5 times of the size of the inner cavity of the heart fixing shell 1. The upper end of the temperature adjusting body 32 is fixedly connected with the upper side of the connecting part 31. And the temperature regulating pipe 4 is provided inside the temperature regulating body 32.
In order to further guarantee the sealed effect of transshipment box, this shell 3 that adjusts temperature still includes: the sealing cover 7, sealing cover 7 includes: the cover body 71 and the sealing plug 72, wherein the sealing plug 72 is fixedly connected with the lower side of the middle part of the cover body 71. The underside of the edge of the cover 71 is detachably connected to the upper side of the connecting portion 31. Preferably, the cover 71 and the connecting portion 31 can be selected to be engaged with each other, and more preferably, the port structure of the connecting portion 31 has a set structure (non-circular structure) and corresponds to the cover 71, so as to ensure the connection between the cover 71 and the connecting portion 31 in a set orientation. The sealing plug 72 is connected with the upper side of the inner cavity of the connecting part 31 in a sealing way.
Preferably, a pressing lever 91 is fixedly connected to the lower side of the cover 71, and a pressing plate 92 is fixedly connected to the lower end of the pressing lever 91. Further preferably, the pressing plate 92 and the pressing rod 91 are both made of elastic materials. And the structural shape of the lower surface of the pressure plate 92 is adapted to the structure of the outer wall of the upper end of the flow-limiting shell 2, and the pressure plate 92 is pressed and fixed on the outer wall of the flow-limiting shell 2 to fix and buffer the flow-limiting shell 2.
In order to improve the protection effect to the transfer box, this transfer box still includes: the protective shell 8 is fixedly connected to the outside of the temperature adjusting shell 3, and a box handle 81 is connected to the outside of the protective shell 8, so that the transport of the transport box is facilitated; of course, in order to improve the cushioning performance of the transfer box, the bottom of the protective shell 8 is provided with a cushioning support pad 82.
In a preferred embodiment, a sliding wheel may be provided at the bottom of the protective casing 8, and a further preferred sliding wheel may be an electric vehicle power-assisted wheel.
In order to realize intelligent control functions such as positioning, temperature control and the like, a control module (which can be an FPGA), a positioning module (which can be a GPS positioning module) and a power supply module (preferably a lithium battery) are arranged in the protective shell 8; a temperature detection sensor (for detecting the temperature inside the temperature adjusting shell 3) is arranged inside the temperature adjusting shell 3.
The information output ends of the temperature detection sensor, the positioning module and the power supply module are connected with the information input end of the control module; the positioning module transmits the positioning information to the control module, and the control module transmits the positioning information to the terminal equipment through a wireless network; the information output end of the control module is connected with the temperature adjusting pipeline 4, the control module sends control information to the temperature adjusting module, and the temperature adjusting pipeline 4 is controlled to heat or refrigerate the temperature adjusting shell 3; the power output end of the power supply module is connected with the control module, the positioning module, the temperature detection sensor and the temperature adjusting pipeline 4.
The positioning module can send the positioning information to the controller in real time, and sends the positioning information to the receptor operating room through the controller, so that the operation doctor can timely give the receptor patient operation treatment on the premise of guaranteeing the supply of the heart, and the timeliness of the operation is guaranteed.
Preferably, temperature sensors may be respectively disposed inside the current limiting casing 2 and inside the temperature adjusting casing 3, and signal output terminals of all the temperature sensors are connected to a signal input terminal of the controller. The temperature regulation precision of the inner part of the current-limiting shell 2 is required to be higher than that of the inner part of the temperature-regulating shell 3, so that the requirement on temperature control is reduced. Further preferably, the temperature inside the current-limiting shell 2 is required to be limited to 4 ℃ with an upper and lower deviation of 0.1 ℃.
Further, can dismantle connection or fixedly connected with battery in 8 lateral parts of protective housing or bottom, the battery can satisfy the 4 mains operated of pipeline that adjust the temperature, the battery has the different interface that charges, guarantees at least that can connect domestic 220V power to and the aircraft machine carries the power.
Preferably, the mesh size of the mesh structure of the heart fixing shell 1 is larger than the mesh size of the mesh structure of the flow limiting shell 2. The grid of the heart fixing shell 1 meets the requirements of fixing the isolated heart and not scratching the isolated heart, the larger the grid is, the better the grid is, and the medium in the current-limiting shell 2 can smoothly enter the surface of the isolated heart. The grid of the current-limiting shell 2 ensures a certain current-limiting effect, and ensures that the medium slowly flows through the current-limiting shell 2 to further achieve the current-limiting effect.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention.

Claims (7)

1. An ex vivo cardiac transfer cassette, comprising: the heart temperature control device comprises a heart fixing shell (1), a flow limiting shell (2) and a temperature adjusting shell (3); the heart fixing shell (1) is connected inside the current limiting shell (2), and the current limiting shell (2) is detachably connected inside the temperature adjusting shell (3);
the heart fixing shell (1) is in the shape of a heart external structure, and the heart fixing shell (1) is in a net structure;
the current limiting shell (2) is of a net structure;
a temperature regulating pipeline (4) is arranged in the temperature regulating shell (3), so that the temperature regulating pipeline (4) has a temperature control effect on a medium in the temperature regulating shell (3);
the heart fixation housing (1) comprises: an upper fixed shell (11) and a lower fixed shell (12); the upper fixing shell (11) and the lower fixing shell (12) are detachably clamped, so that the isolated heart is limited and fixed in the heart fixing shell (1);
the upper fixing shell (11) and the lower fixing shell (12) are made of flexible materials;
the current limiting case (2) includes: an upper flow restricting shell (21) and a lower flow restricting shell (22); the upper current limiting shell (21) and the lower current limiting shell (22) are detachably clamped;
the flow limiting shell (2) is made of a hard material;
further comprising: a mount (6), the mount (6) comprising: a buffer fixing rod (61) and a fixing plate (62); the upper end and the lower end of the buffering fixing rod (61) are respectively fixedly connected with the inner cavity of the temperature adjusting shell (3) and the lower surface of the fixing plate (62) to support and fix the fixing plate (62); at least two positioning holes are formed in the fixing plate (62), at least two positioning protrusions (23) corresponding to the positioning holes are integrally formed at the bottom of the lower flow limiting shell (22) or fixedly connected with the bottom of the lower flow limiting shell, and the positioning protrusions (23) are suitable for being inserted into the positioning holes to fix the flow limiting shell (2).
2. The isolated heart transfer box according to claim 1, wherein the upper fixing shell (11) and the lower fixing shell (12) are provided with vein vessel limiting cavities (13) at the upper sides thereof, wherein the vein vessel limiting cavities are adapted to the heart structure.
3. The isolated heart transfer box according to claim 1, wherein the upper end of the heart fixing shell (1) is open, and a limit buckle (14) is arranged on one side of the upper end of the heart fixing shell (1) and is adapted to the position of the heart aorta.
4. The isolated heart transfer box of claim 1, wherein a plurality of buffer support rods (5) are fixedly connected between the lower side of the lower stationary shell (12) and the inner side of the lower flow-limiting shell (22).
5. The isolated heart transfer cassette of claim 1, wherein the tempering housing (3) comprises: the bottom of the temperature adjusting main body (32) is similar to the bottom of the inner cavity of the heart fixing shell (1), and the size of the bottom of the temperature adjusting main body (32) is 2.5-3.5 times of the size of the inner cavity of the heart fixing shell (1); the upper end of the temperature adjusting main body (32) is fixedly connected with the upper side of the connecting part (31); the temperature adjusting pipeline (4) is arranged inside the temperature adjusting main body (32);
the temperature-regulating housing (3) further comprises: a sealing cover (7), the sealing cover (7) comprising: the sealing structure comprises a cover body (71) and a sealing plug (72), wherein the sealing plug (72) is fixedly connected to the lower side of the middle of the cover body (71), the lower side of the edge of the cover body (71) is detachably connected to the upper side of the connecting part (31), and the sealing plug (72) is connected to the upper side of the inner cavity of the connecting part (31) in a sealing mode.
6. The ex vivo cardiac transfer cassette of claim 5, further comprising: the protective shell (8), the protective shell (8) is fixedly connected to the outside of the temperature adjusting shell (3), and a box handle (81) is connected to the outside of the protective shell (8); the bottom of the protective shell (8) is provided with a buffer supporting pad (82);
a control module, a positioning module and a power supply module are arranged in the protective shell (8); a temperature detection sensor is arranged in the temperature adjusting shell (3); the information output ends of the temperature detection sensor, the positioning module and the power supply module are connected with the information input end of the control module; the positioning module transmits positioning information to the control module, and the control module transmits the positioning information to the terminal equipment through a wireless network; the information output end of the control module is connected with the temperature adjusting pipeline (4), the control module sends control information to the temperature adjusting module, and the temperature adjusting pipeline (4) is controlled to heat or refrigerate the temperature adjusting shell (3); and the power output end of the power supply module is connected with the control module, the positioning module, the temperature detection sensor and the temperature adjusting pipeline (4).
7. The isolated heart transfer box according to claim 1, wherein the mesh size of the mesh structure of the heart fixation shell (1) is larger than the mesh size of the mesh structure of the flow-limiting shell (2).
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CN112471135A (en) * 2020-12-03 2021-03-12 李建朝 Normal-temperature isolated heart transfer device
CN112687171B (en) * 2020-12-17 2022-09-27 杭州堃博生物科技有限公司 Multi-functional lung clamping and supporting equipment
CN112687143B (en) * 2020-12-17 2022-09-27 杭州堃博生物科技有限公司 Lung clamping and supporting equipment with heat preservation effect
CN113647379A (en) * 2021-07-18 2021-11-16 华中科技大学同济医学院附属协和医院 Non-hemolysis continuous-jumping off-body heart transfer device

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