CN110314203A - A kind of sucking eliminating phlegm medicine pharmaceutical solutions and preparation method thereof - Google Patents
A kind of sucking eliminating phlegm medicine pharmaceutical solutions and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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Abstract
The present invention relates to a kind of sucking eliminating phlegm medicine pharmaceutical solutions and preparation method thereof, belong to galenic pharmacy field.A kind of sucking eliminating phlegm medicine pharmaceutical solutions, comprising: effective component, isotonic agent and solvent, wherein effective component includes fresh bamboo sap and the effective component that cordate houttuynia is extracted.Sucking eliminating phlegm medicine pharmaceutical solutions provided by the invention, can quickly form aerosol by atomizer, direct snap action is quickly absorbed action at sufferer；Not only dosage is few, and rapid-action, good effect, without other toxic side effects.
Description
Technical field
The present invention relates to a kind of sucking eliminating phlegm medicine pharmaceutical solutions and preparation method thereof, belong to galenic pharmacy field.
Background technique
Eliminating the phlegm, also known as resolving sputum, i.e., it is turbid with the phlegm that excludes or dissipate with expectorant, treat the therapy of various phlegm diseases.Phlegm be by
Body fluid metabolism obstacle, water-wet is gathered and the pathological product of generation, it is used as the cause of disease to lead to various phlegm diseases again.Phlegm not only can be with
Lung is rested on, other positions of human body can also be rested on, therefore there are many disease caused by phlegm, the application of expelling phlegm method is also very wide
It is general.It is usually used in stagnant phlegm to cough up phlegm in the cough and asthma that lung causes；The turbid chest distress and palpitation symptoms being confused the heart and causing of phlegm, coma are demented；Phlegm is parked in stomach and causes
Nausea and vomiting, feeling of fullness do not relax；The scrofula subcutaneous nodule that phlegm is caused in channels and collaterals muscles and bones, extremity numbness or hemiplegia, or negative subcutaneous ulcer stream
Note；Phlegm it is turbid it is upper criminal and cause dizziness；The globus hysteriocus etc. that mental disorder knot is caused in throat.According to the cause of disease of phlegm, property and different
Clinical manifestation, expelling phlegm method are often divided into eliminating dampness and eliminating phlegm, clearing heat and eliminating phlegm, warming cold phlegm, moistening dryness and resolving phlegm, calming wind and eliminating phlegm etc. again.
The band root that cordate houttuynia is Saururaceae herbaceos perennial heartleaf houttuynia Houttuynia cordata Thunb. is complete
Grass, also known as root of picking up the ears, purple Ji, hog snout hole, Rhizoma Rohdeae Japonicae etc. have pungent bad smell after Fresh Plants are broken, are distributed widely in
Central China, each provinces and regions in the southeast and southwest, are saved especially with Hunan, Hubei, Sichuan, Jiangsu etc. in the majority.Cordate houttuynia is mainly with young stem and leaf
With subterranean stem for for vegetable consumption, complete stool fresh or dried can be used as medicine, and be formally determined as " being both medicine by health ministry
One of the resource of great exploitation potential of product, and be food ", is increasingly subject to the concern of people.Cordate houttuynia have it is clearing heat and detoxicating, disappear
The effect of carbuncle apocenosis, inducing diuresis for treating strangurtia, is clinically used for the illnesss such as lung carbuncle pyemesis, phlegm heat panting cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.Research
Show in cordate houttuynia containing ingredients such as volatile component, flavonoids, organic acid, sterols, alkaloids.
Fresh bamboo sap is a kind of traditional Chinese medicine, is recorded in " Chinese medicine " first (1992), people are earliest using fresh bamboo sap
Quenched the thirst based on field, is its minister Yu Qian for treating disease to Ming Dynasty Shi Zengyou emperor, but be also only civil folk prescription at that time, after
Constantly explored so far through successive dynasties medicine and pharmacology man, fresh bamboo sap in food (beverage), health care product, pharmaceutical preparations, be developed and
Certainly, especially medicine acts on the research and development of aspect faster.Modern research shows that contain more than 10 kinds of amino acid in fresh bamboo sap, wherein
Tyrosine accounts for the 55-68% of total content, also containing organic compounds such as guaiacol, gluconic acid, salicylic acid, phenol, germanium, silicon
Composition；There is therapeutic effect to cough and bronchitis.Fresh bamboo sap is sweet in flavor cold in nature, return heart, lung, stomach meridian, and the extremely sliding benefit of property, is simply
The very strong Chinese medicine of slit phlegm power walks key by all places above and below phlegm energy extending from the interior to the exterior.Therefore, have by drug made of raw material of fresh bamboo sap
The effect of significant heat-clearing, resolving sputum, cough-relieving.Have using cordate houttuynia and fresh bamboo sap as the prescription eliminating phlegm medicine of active constituent significant clear
Heat, resolving sputum, detoxication.
Aerosol inhalation solution preparation can directly act on lesions position as respiratory tract or pulmonary administration preparation, improve
The administration concentration of respiratory tract or lung, it is rapid-action, and said preparation avoids the first pass effect of liver, reduce drug to medicament
Amount improves drug bioavailability, and reduces drug in the distribution of its hetero-organization, reduces side effect.Neulized inhalation is with molten at present
The product of liquid formulation listing is relatively fewer, predominantly imported product.Clinically with injection application Neulized inhalation the case where, is more,
But there is no the application method of specification in specification, category Use overrun, therefore there is security risk in use.Existing skill
The special preparation of eliminating phlegm medicine prescription Neulized inhalation is also not present in art.It is high to provide a kind of bioavilability, directly acts on lesion portion
Position, safely and effectively Neulized inhalation becomes urgent problem to be solved with pharmaceutical solutions.
Summary of the invention
The invention mainly solves the technical problem of providing a kind of sucking eliminating phlegm medicine safely, effectively, quality controllable is molten
Liquid formulation；The present invention also provides the preparation methods of said preparation, and the preparation method is simple to operation, are conducive to industrialized production.
The first object of the present invention is to provide a kind of sucking eliminating phlegm medicine pharmaceutical solutions, is achieved through the following technical solutions
:
A kind of sucking eliminating phlegm medicine pharmaceutical solutions, comprising: effective component, isotonic agent and solvent, wherein effective component includes
The effective component that fresh bamboo sap and cordate houttuynia are extracted.
Eliminating phlegm medicine sucking pharmaceutical solutions as described above, in every liter of eliminating phlegm medicine sucking pharmaceutical solutions, effectively
Ingredient includes by raw material fresh bamboo sap 200-700mL (such as 300mL, 400mL, 450mL, 500mL, 600mL, 700mL), cordate houttuynia
80-350g (such as 90g, 100g, 120g, 150g, 180g, 200g, 220g, 250g, 280g, 300g, 320g) is extracted effective
Ingredient.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, as a preferred implementation manner, in every liter of sucking with molten
In liquid formulation, the effective component includes the effective component extracted by fresh bamboo sap 300-600mL and cordate houttuynia 120-250g.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, as another preferred embodiment, used in every liter of sucking
In pharmaceutical solutions, the effective component includes the effective component extracted by fresh bamboo sap 400-500mL and cordate houttuynia 150-200g.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, the isotonic agent is inorganic salts as a preferred implementation manner,
Isotonic agent or carbohydrate isotonic agent.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, as a preferred implementation manner, in every liter of sucking with molten
In liquid formulation, the quality of the inorganic salts isotonic agent be 1-20g (such as 1.5g, 2g, 3g, 4g, 5g, 6g, 7g, 8g, 9g, 10g,
11g,12g,13g,14g,15g,16g,17g,18g,19g)；The inorganic salts isotonic agent is preferably sodium chloride, magnesium chloride, chlorination
One of calcium is a variety of, more preferably sodium chloride.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, as a preferred implementation manner, in every liter of sucking with molten
In liquid formulation, the quality of the carbohydrate isotonic agent be 10-100g (such as 15g, 20g, 25g, 30g, 40g, 50g, 60g, 70g,
80g,90g,95g)；The carbohydrate isotonic agent is preferably one of glucose, fructose, mannitol or a variety of.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, the solvent selects purified water as a preferred implementation manner,
Or water for injection, preferred water for injection.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, can also include as a preferred implementation manner, pH adjusting agent,
Cosolvent.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, the pH adjusting agent is hydrogen as a preferred implementation manner,
One of sodium oxide molybdena, sodium citrate, citric acid, sodium dihydrogen phosphate, disodium hydrogen phosphate, phosphoric acid, sodium acetate, acetic acid, hydrochloric acid or
It is a variety of, preferably sodium hydroxide and hydrochloric acid.
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, pharmaceutical solutions are used in the sucking as a preferred implementation manner,
PH value be 3.0-8.5 (such as pH value be 3.5,4.0,4.5,5.0,5.5,6.0,6.5,7.0,7.5)；Preferably, pH value is
5.0-8.0。
In above-mentioned sucking in eliminating phlegm medicine pharmaceutical solutions, as a preferred implementation manner, the cosolvent be selected from ethyl alcohol,
One of propylene glycol, glycerol, polyethylene glycol, Emulsifier EL-60, poloxamer, sapn or polysorbate are a variety of, excellent
Select polysorbate, more preferable Tween-80.
Further, the dosage of the cosolvent in the formulation be 0.01-0.7%, preferably 0.02-0.5%, more preferably
0.05-0.3%.
By the rational allocation to sucking with effective component concentration in eliminating phlegm medicine pharmaceutical solutions, not only contributes to it and form gas
The ability of colloidal sol, and its drug effect can be improved, moreover it is possible to reduce its irritation for acting on patient.
In the present invention, gained inhalation solution preparation is made into eliminating the phlegm with ultrasonic atomizer or air compression type atomizer
Clever sucking is directly sucked in respiratory system with solution with atomised form, directly acts on lesions position, rapid-action, safer and more effective.
Another object of the present invention, which also resides in, provides a kind of preparation method of sucking eliminating phlegm medicine pharmaceutical solutions, described
Method includes:
(1) recipe quantity fresh bamboo sap (preparation or commercially available) is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration,
Ultrafiltration obtains fresh bamboo sap effective component；
(2) recipe quantity cordate houttuynia is taken, the 8-15 times of water measured is added, is distilled, distillate 100-300ml is collected, obtains fish
Raw meat grass effective component；
(3) it takes fresh bamboo sap effective ingredient and cordate houttuynia effective component to merge, adjusts pH value to 3.0-8.5, isotonic agent, filter is added
It crosses, encapsulating, sterilizes to get solution of the invention.
In the above preparation method, as a preferred implementation manner, in the step (3), merge fresh bamboo sap and fish raw meat
Appropriate cosolvent can be added to increase the dissolubility of effective component, the preferred polyoxyethylene sorbitan monoleate of cosolvent after the effective component of grass.
In the above preparation method, wherein 10-12 times is preferably added in step (2) as a preferred implementation manner, to measure
Water distilled, preferably collection distillate 250ml.
In the above preparation method, as a preferred implementation manner, in the step (3), preferably by the pH value of solution
It is adjusted to 3.0-8.5, the pH value of solution is more preferably adjusted to 5.0-8.0.
The effective ingredient consumption of sucking of the present invention solution is 0.1-1.0 times of Qutanling oral liquid dosage；It is preferred that
Dosage is 0.1-0.6 times of Qutanling oral liquid.
Sucking eliminating phlegm medicine pharmaceutical solutions of the present invention have the effect of clearing lung-heat, resolving sputum, removing toxic substances, can be used for treating lung
Heat-syndrome cough phlegm, coughing with a lot of sputum, acute and chronic bronchitis, tracheitis etc..Therefore, the third object of the present invention is to provide above-mentioned suction
Enter the effect with eliminating phlegm medicine pharmaceutical solutions in the drug for the treatment of respiratory disease, the respiratory disease includes but is not limited to branch
Tracheitis, cough, more phlegm etc..
Compared with prior art, the present invention has the following technical effect that
1, sucking eliminating phlegm medicine pharmaceutical solutions provided by the invention, can quickly form aerosol by atomizer, directly
Snap action is quickly absorbed action at sufferer；Not only dosage is few, and rapid-action, good effect, and no other poison are secondary to be made
With.
2, sucking eliminating phlegm medicine pharmaceutical solutions provided by the invention, drug are dissolved in suitable media, borrow atomizer with gas
Solation, oral nasal inhalation are delivered to respiratory tract or lung, and through lesions position is administered, reduces drug in other organizers
The drug concentration of the distribution of official, local lesion is high, and for being relatively administered orally, the treatment total effective rate of inhalation mode is substantially mentioned
Height, has safely and effectively, the feature that bioavilability is high, toxic side effect is small, thus has compared to the oral preparation listed at present
Clear superiority.
3, pharmaceutical solutions prepared by the present invention compensate for the blank on domestic market, and solution prepared by the present invention
Preparation is to aim at sucking to be designed with patient, is matched with atomizer, use process is convenient.It can avoid needed for oral administration simultaneously
It by the first pass effect of liver, is damaged to caused by patient, increases the compliance of patient, be for the children for being inconvenient to be administered orally
A kind of good administration route.
Specific embodiment
The dosage of substance used in substance used in the production process and preparation of following pharmaceutical preparation embodiment or preparation is not limited to
Character express, all formulation methods containing pharmaceutical composition provided by the invention, all belongs to the scope of protection of the present invention.
Embodiment 1
(1) fresh bamboo sap 200ml is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration, ultrafiltration obtains fresh bamboo sap
Effective component；
(2) cordate houttuynia 80g is taken, 8 times of amount water are added, are distilled, distillate 100ml is collected, obtains cordate houttuynia effective component；
(3) fresh bamboo sap effective ingredient and cordate houttuynia effective component are taken, merges, is stirred to dissolve；Hydrochloric acid is added and adjusts pH in right amount
To 3.0 isotonic agent, filtration is added, encapsulating sterilizes to get solution of the invention in value.
Embodiment 2
Sucking eliminating phlegm medicine pharmaceutical solutions 1000ml
(1) fresh bamboo sap 300ml is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration, ultrafiltration obtains fresh bamboo sap
Effective component；
(2) take cordate houttuynia 120g, 9 times of amount water be added, are distilled, collect distillate 150ml, obtain cordate houttuynia effectively at
Point；
(3) fresh bamboo sap effective ingredient and cordate houttuynia effective component are taken, merges, it is appropriate that appropriate cosolvent polyoxyethylene sorbitan monoleate is added
Stirring makes it completely dissolved；Acetic acid and sodium acetate buffer tune pH value is added to 4.0, isotonic agent, filtration is added, encapsulating is gone out
Bacterium is to get solution of the invention.
Embodiment 3
Sucking eliminating phlegm medicine pharmaceutical solutions 1000ml
(1) fresh bamboo sap 400ml is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration, ultrafiltration obtains fresh bamboo sap
Effective component；
(2) take cordate houttuynia 150g be added 10 times of amount water, distilled, collection distillate 200ml, obtain cordate houttuynia effectively at
Point；
(3) fresh bamboo sap effective ingredient and cordate houttuynia effective component are taken, is merged, appropriate cosolvent polyoxyethylene sorbitan monoleate stirring is added
It makes it completely dissolved；Citric acid is added and sodium citrate buffer solution is appropriate, adjusts pH value to 5.0, isotonic agent is added, filters, fills
Envelope sterilizes to get solution of the invention.
Embodiment 4
Sucking eliminating phlegm medicine pharmaceutical solutions 1000ml
(1) fresh bamboo sap 430ml is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration, ultrafiltration obtains fresh bamboo sap
Effective component；
(2) it takes cordate houttuynia 200g that 10 times of amount aqueous solutions are added, is distilled, collect distillate 250ml, it is effective to obtain cordate houttuynia
Ingredient；
(3) fresh bamboo sap effective ingredient and cordate houttuynia effective component are taken, is merged, appropriate cosolvent polyoxyethylene sorbitan monoleate stirring is added
It makes it completely dissolved；It adjusts pH value to 7.0, isotonic agent, filtration is added, encapsulating sterilizes to get solution of the invention.
Embodiment 5
(1) fresh bamboo sap 500ml is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration, ultrafiltration obtains fresh bamboo sap
Effective component；
(2) it takes cordate houttuynia 230g that 11 times of amount aqueous solutions are added, is distilled, collect distillate 250ml, it is effective to obtain cordate houttuynia
Ingredient；
(3) fresh bamboo sap effective ingredient and cordate houttuynia effective component are taken, is merged, appropriate cosolvent polyoxyethylene sorbitan monoleate stirring is added
It makes it completely dissolved；It adjusts pH value to 6.0, isotonic agent, filtration is added, encapsulating sterilizes to get solution of the invention.
Embodiment 6
(1) fresh bamboo sap 600ml is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration, ultrafiltration obtains fresh bamboo sap
Effective component；
(2) it takes cordate houttuynia 250g that 10 times of amount aqueous solutions are added, is distilled, collect distillate 250ml, it is effective to obtain cordate houttuynia
Ingredient；
(3) fresh bamboo sap effective ingredient and cordate houttuynia effective component are taken, is merged, appropriate cosolvent polyoxyethylene sorbitan monoleate stirring is added
Make to dissolve；It adjusts pH value to 7, isotonic agent, filtration is added, encapsulating sterilizes to get solution of the invention.
Embodiment 7
(1) fresh bamboo sap 700ml is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration, ultrafiltration obtains fresh bamboo sap
Effective component；
(2) it takes cordate houttuynia 350g that 12 times of amount aqueous solutions are added, is distilled, collect distillate 250ml, it is effective to obtain cordate houttuynia
Ingredient；
(3) fresh bamboo sap effective ingredient and cordate houttuynia effective component are taken, is merged, appropriate cosolvent polyoxyethylene sorbitan monoleate stirring is added
Make to dissolve；It adjusts pH value to 8.0, isotonic agent, filtration is added, encapsulating sterilizes to get solution of the invention.
Beneficial effects of the present invention are further illustrated below by way of test example
Influence of the experimental example to mouse tracheae section phenols contents
Kunming mouse 90, half male and half female, weight 18-22g；It raises in 20-26 DEG C of SPF grades of animal feeding room, from
By diet, drinking-water.9 groups are randomly divided into, every group 10, respectively (pharmacy of Shanghai Jing'an is limited for model group, Qutanling oral liquid group
Company), atomized medicine introducing embodiment 1-7 group.Oral solution and inhalation solution carry out equivalent conversion appropriate.Model group Neulized inhalation is given
The isometric sodium chloride injection of medicine, oral solution group are 3.9ml/kg, and atomized medicine introducing embodiment 1-7 group dosage is 3.9ml/
kg.It is administered daily 1 time, for three days on end.After last dose 30min, 5% phenol red solution (0.1ml/10g) is injected intraperitoneally, injects
Mouse is put to death after phenol red 30min, trachea cannula is drawn the total 2ml of 5% sodium bicarbonate with syringe, repeated flushing tracheae 3 times, merged
Flushing liquor surveys OD value in wavelength 546nm with 751 spectrophotometers, the results are shown in Table 1.
The influence of 1 oral administration group of table and atomized medicine introducing group to mouse tracheae section phenols contents
Note: compared with model group*P < 0.05,**P<0.01；Compared with oral granular formulation group:▼P < 0.05,▼▼P<0.01；
As a result: experimental data shows that compared with oral solution administration group, atomized soln preparation of the invention can dramatically increase
Mouse tracheae section phenols contents show that atomized soln preparation expectorant effect of the invention becomes apparent from, and effect is better than eliminating phlegm medicine
Oral solution group.
Claims (15)
1. a kind of sucking eliminating phlegm medicine pharmaceutical solutions, comprising: effective component, isotonic agent and solvent, wherein the effective component packet
Include the effective component of fresh bamboo sap and cordate houttuynia extraction.
2. pharmaceutical solutions according to claim 1, wherein in every liter of sucking eliminating phlegm medicine pharmaceutical solutions, it is described effective
Ingredient includes fresh bamboo sap 200-700mL, the effective component that cordate houttuynia 80-350g is extracted.
3. pharmaceutical solutions according to claim 1 or 2, which is characterized in that the effective component includes by fresh bamboo sap 300-
The effective component that 600mL and cordate houttuynia 120-250g is extracted.
4. described in any item pharmaceutical solutions according to claim 1~3, which is characterized in that the effective component includes by fresh bamboo
Drip the effective component that 400-500mL and cordate houttuynia 150-200g is extracted.
5. pharmaceutical solutions according to any one of claims 1 to 4, which is characterized in that the isotonic agent is that inorganic salts are isotonic
Agent or carbohydrate isotonic agent.
6. pharmaceutical solutions according to claim 5, which is characterized in that the quality of the inorganic salts isotonic agent is 1-20g, institute
Stating inorganic salts isotonic agent is preferably one of sodium chloride, magnesium chloride, calcium chloride or a variety of；The quality of the carbohydrate isotonic agent is
10-100g, the carbohydrate isotonic agent are preferably one of glucose, fructose, mannitol or a variety of.
7. described in any item pharmaceutical solutions according to claim 1~6, which is characterized in that the solvent selects purified water or note
It penetrates and uses water.
8. described in any item pharmaceutical solutions according to claim 1~7, which is characterized in that can also include pH adjusting agent, hydrotropy
Agent.
9. described in any item pharmaceutical solutions according to claim 1~8, which is characterized in that the cosolvent is selected from ethyl alcohol, the third two
One of alcohol, glycerol, polyethylene glycol, Emulsifier EL-60, poloxamer, sapn or polysorbate are a variety of, preferably poly-
Sorb ester, more preferable Tween-80.
10. pharmaceutical solutions according to claim 8, which is characterized in that the pH adjusting agent of stating is sodium hydroxide, citron
One of sour sodium, citric acid, sodium dihydrogen phosphate, disodium hydrogen phosphate, phosphoric acid, sodium acetate, acetic acid, hydrochloric acid are a variety of.
11. -10 described in any item pharmaceutical solutions according to claim 1, which is characterized in that the Neulized inhalation pharmaceutical solutions
PH value be 3.0-8.5, preferable ph 5.0-8.0.
12. described in any item pharmaceutical solutions according to claim 1~11, which is characterized in that preparation method the following steps are included:
(1) recipe quantity fresh bamboo sap is taken, 0.05% active carbon is added, stirs evenly, is stood more than for 24 hours, filtration, it is effective that ultrafiltration obtains fresh bamboo sap
Ingredient；
(2) take recipe quantity cordate houttuynia, the 8-15 times of water measured be added, is distilled, it is appropriate to collect distillate, obtain cordate houttuynia effectively at
Point；
(3) fresh bamboo sap effective ingredient and cordate houttuynia effective component are taken, is merged, adjusts pH value to 3.0-8.5, addition isotonic agent filters,
Encapsulating, sterilizing to get.
13. pharmaceutical solutions according to claim 12, which is characterized in that be preferably added in step (2) 10-12 times measure water into
Row distillation, collection distillate are 100-300ml, and preferably collection distillate is 200-250ml.
14. pharmaceutical solutions according to claim 12 or 13, which is characterized in that in the step (3), merge fresh bamboo sap and
Appropriate cosolvent, the preferred polyoxyethylene sorbitan monoleate of cosolvent are added after the effective component of cordate houttuynia.
15. effect of the described in any item pharmaceutical solutions of claim 1~14 in the drug of preparation treatment respiratory disease, institute
Stating respiratory disease includes bronchitis, cough, more phlegm.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857710A (en) * | 2006-03-16 | 2006-11-08 | 何祖兴 | Chinese medicine syrup for relieving cough and reducing sputum and its preparing process and quality control method |
| CN107789340A (en) * | 2016-08-30 | 2018-03-13 | 北京盈科瑞创新医药股份有限公司 | A kind of Herba Andrographitis Neulized inhalation pharmaceutical solutions and preparation method thereof |
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2018
- 2018-03-29 CN CN201810268084.5A patent/CN110314203A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857710A (en) * | 2006-03-16 | 2006-11-08 | 何祖兴 | Chinese medicine syrup for relieving cough and reducing sputum and its preparing process and quality control method |
| CN107789340A (en) * | 2016-08-30 | 2018-03-13 | 北京盈科瑞创新医药股份有限公司 | A kind of Herba Andrographitis Neulized inhalation pharmaceutical solutions and preparation method thereof |
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| Title |
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| 吴治德,等主编: "《内科学基础与诊疗精要 下》", 30 June 2016, 吉林科学技术出版社 * |
| 国家药典委员会编: "《中华人民共和国药典 2015年版 一部》", 30 June 2015, 中国医药科技出版社 * |
| 王兆东等: "呼吸道药物递送―雾化吸入剂的研究进展", 《世界临床药物》 * |
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