CN110302353A - Blood-activating and menstruation-regulating medicinal compositions and preparation method thereof - Google Patents
Blood-activating and menstruation-regulating medicinal compositions and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of blood-activating and menstruation-regulating medicinal compositions and preparation method thereof, and raw material is mainly grouped as by the group of following parts by weight: 1248 parts of motherwort, 156 parts of Radix Angelicae Sinensis, 178 parts of Rhizoma Chuanxiong, 78 parts of baked ginger.The preparation method effectively reduces volatile oil and volatilizees in production and storage process, reduces the loss of effective component, increases the stability of drug, it overcomes disintegration existing for conventional tablet, capsule and works slower, the problems such as dissolution rate is low, and bioavilability is lower has disintegration rate fast, dissolution is preferable, it absorbs comparatively fast, onset of action is fast, and bioavilability is high, the advantages that adverse reaction is few, convenient to take.
Description
Technical field
The present invention relates to medicine fields, and in particular to a kind of blood-activating and menstruation-regulating medicinal compositions and preparation method thereof.
Background technique
Puerperal blood clot dispersing tablet is recorded in the 15th WS3-B-2882-98 of the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation, by benefit
Brittle Falsepimpernel Herb, Radix Angelicae Sinensis, Rhizoma Chuanxiong and four taste Chinese medicine of baked ginger and auxiliary material are prepared, and have promoting blood circulation for regulating menstruation, and the function of stasis eliminatings analgesic becomes silted up for postpartum
Blood is not clean, young married woman's abdominal pain.The original preparation process of blood-activating and menstruation-regulating medicinal compositions is that each 20g of motherwort, Radix Angelicae Sinensis, Rhizoma Chuanxiong is crushed in side
It is used as medicine at fine powder, the dregs of a decoction are added water to cook with remaining motherwort after remaining Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger extract volatile oil, are filtered, filtrate
Merge, be condensed into thick paste, above-mentioned fine powder is added, mixes, it is dry, it makes pellet, it is dry, the volatile oil such as Radix Angelicae Sinensis are added, mix, pressure
Piece to get.Blood-activating and menstruation-regulating medicinal compositions are not clean to curing postpartum bleeding, and young married woman's abdominal pain has certain effect.Due to original preparation work
Volatile oil is readily volatilized in production and storage in skill, is easy to cause drug quality unstable, and part in former preparation method
Medicinal material crude drug powder is used as medicine, un-extracted, and impurity component is more, and Chinese medical extract impurity is few as far as possible when being unable to satisfy dispersible tablet preparation
Requirement.
Summary of the invention
It is an object of the invention to be directed to the deficiency of puerperal blood clot dispersing tablet preparation process, is reasonably reformed, one kind is provided
Blood-activating and menstruation-regulating medicinal compositions of good drug efficacy and preparation method thereof.
The technical solution adopted in the present invention is as follows:
A kind of blood-activating and menstruation-regulating medicinal compositions, raw material are mainly grouped as by the group of following parts by weight: 1248 parts of motherwort,
156 parts of Radix Angelicae Sinensis, 178 parts of Rhizoma Chuanxiong, 78 parts of baked ginger, preparation method includes the following steps:
R1. motherwort, Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger are taken respectively, are cleaned, it is dry；
R2. component is weighed by following parts by weight: 1248 parts of motherwort, 156 parts of Radix Angelicae Sinensis, 178 parts of Rhizoma Chuanxiong, 78 parts of baked ginger；
R3. it takes Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger to be crushed to 30~50 mesh, is uniformly mixed, extract volatile oil, collect volatile oil, steam
Aqueous, the dregs of a decoction after evaporating is spare；
R4. the volatile oil for taking step R3 prepares volatile oil inclusion complex；
R5. the dregs of a decoction of step R3 and motherwort add ethanol solution refluxing extraction, filter, after filtrate recycling ethanol, with step
The aqueous of R4 merges, and ceramic membrane is crossed in concentration, collects filtered solution, is concentrated into thick paste, is dried under reduced pressure, get dry extract powder, crushed 100
Mesh obtains medicinal substances extract；
R6. low-substituted hydroxypropyl cellulose, superfine silica gel powder, calcium sulfate, magnesium stearate are taken respectively, and crushing sieves with 100 mesh sieve, standby
With；
R7. component is weighed by following parts by weight: 20 parts of low-substituted hydroxypropyl cellulose, 15 parts of calcium sulfate, superfine silica gel powder 1
Part, 1 part of magnesium stearate；
R8. it takes medicinal substances extract, low-substituted hydroxypropyl cellulose, calcium sulfate to be added in blender, is stirring evenly and then adding into
Softwood is made in 5% polyvinylpyrrolidone ethanol solution after mixing evenly, crosses the granulation of 50 mesh, dry, and step R4 is added after whole grain
Volatile oil inclusion complex, be added superfine silica gel powder, magnesium stearate, mix, tabletting to get.
Further, above-described blood-activating and menstruation-regulating medicinal compositions, preparation methods steps R3 extract the side of volatile oil
Method are as follows: the water of 6 times of amounts is added to extract volatile oil 5 hours.
Further, above-described blood-activating and menstruation-regulating medicinal compositions, described in step R5 plus ethanol solution refluxing extraction is
Add 6~10 times of amounts 50% ethanol solution heating and refluxing extraction 2~3 times, every time 1~2 hour.
Further, above-described blood-activating and menstruation-regulating medicinal compositions, preparation methods steps R5 concentration are to be concentrated into life
Medicine: medical fluid=1:6~1:10, ceramic membrane are the ceramic membrane that aperture is 0.1 μm.
Further, above-described blood-activating and menstruation-regulating medicinal compositions, preparation methods steps R4 prepare volatile oil inclusion
The method of object are as follows:
S1. in beta-cyclodextrin: volatile oil=8: the ratio of 1 (g: ml) weighs beta-cyclodextrin；
S2. plus Purified Water q. s, it is heated to 90 DEG C~100 DEG C and saturated solution is made；
S3. saturated solution is let cool to 30 DEG C~40 DEG C, is slowly added to volatile oil while stirring, be maintained at 30 DEG C~40 DEG C
Stirring 2 hours is taken out, is let cool, and seals, and cold place is placed 6 hours；
S4. liquid is discarded supernatant, the inclusion complex that lower layer is precipitated is taken out, filtering takes filtered inclusion complex in 30 DEG C~40 DEG C
It is dried under reduced pressure；
S5. dry inclusion complex crosses 60 meshes, obtains inclusion complex.
A kind of preparation method of blood-activating and menstruation-regulating medicinal compositions as described above, comprising the following steps:
R1. motherwort, Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger are taken respectively, are cleaned, it is dry；
R2. component is weighed by following parts by weight: 1248 parts of motherwort, 156 parts of Radix Angelicae Sinensis, 178 parts of Rhizoma Chuanxiong, 78 parts of baked ginger；
R3. it takes Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger to be crushed to 30~50 mesh, is uniformly mixed, extract volatile oil, collect volatile oil, steam
Aqueous, the dregs of a decoction after evaporating is spare；
R4. the volatile oil for taking step R3 prepares volatile oil inclusion complex；
R5. the dregs of a decoction of step R3 and motherwort add ethanol solution refluxing extraction, filter, after filtrate recycling ethanol, with step
The aqueous of R4 merges, and ceramic membrane is crossed in concentration, collects filtered solution, is concentrated into thick paste, is dried under reduced pressure, get dry extract powder, crushed 100
Mesh obtains medicinal substances extract；
R6. low-substituted hydroxypropyl cellulose, superfine silica gel powder, calcium sulfate, magnesium stearate are taken respectively, and crushing sieves with 100 mesh sieve, standby
With；
R7. component is weighed by following parts by weight: 20 parts of low-substituted hydroxypropyl cellulose, 15 parts of calcium sulfate, superfine silica gel powder 1
Part, 1 part of magnesium stearate；
R8. it takes medicinal substances extract, low-substituted hydroxypropyl cellulose, calcium sulfate to be added in blender, is stirring evenly and then adding into
Softwood is made in 5% polyvinylpyrrolidone ethanol solution after mixing evenly, crosses the granulation of 50 mesh, dry, and step R4 is added after whole grain
Volatile oil inclusion complex, be added superfine silica gel powder, magnesium stearate, mix, tabletting to get.
Further, above-described blood-activating and menstruation-regulating medicinal compositions, preparation methods steps R3 extract the side of volatile oil
Method is plus the water of 6 times of amounts extracts volatile oil 5 hours.
Further, above-described blood-activating and menstruation-regulating medicinal compositions, described in step R5 plus ethanol solution refluxing extraction is
Add 6~10 times of amounts 50% ethanol solution heating and refluxing extraction 2~3 times, every time 1~2 hour.
Further, above-described blood-activating and menstruation-regulating medicinal compositions, preparation methods steps R5 concentration are to be concentrated into life
Medicine: medical fluid=1:6~1:10, ceramic membrane are the ceramic membrane that aperture is 0.1 μm.
Further, above-described blood-activating and menstruation-regulating medicinal compositions, preparation methods steps R4 prepare volatile oil inclusion
The method of object are as follows:
S1. in beta-cyclodextrin: volatile oil=8: the ratio of 1 (g: ml) weighs beta-cyclodextrin；
S2. plus Purified Water q. s, it is heated to 90 DEG C~100 DEG C and saturated solution is made；
S3. saturated solution is let cool to 30 DEG C~40 DEG C, is slowly added to volatile oil while stirring, be maintained at 30 DEG C~40 DEG C
Stirring 2 hours is taken out, is let cool, and seals, and cold place is placed 6 hours；
S4. liquid is discarded supernatant, the inclusion complex that lower layer is precipitated is taken out, filtering takes filtered inclusion complex in 30 DEG C~40 DEG C
It is dried under reduced pressure；
S5. dry inclusion complex crosses 60 meshes, obtains inclusion complex.
The beneficial effects of the present invention are:
1. the preparation method of blood-activating and menstruation-regulating medicinal compositions provided by the invention, using beta-cyclodextrin inclusion it is volatile at
Point --- Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger volatile oil effectively reduce volatile oil and volatilize in production and storage process, reduces effective component
Loss, increase the stability of drug, overcome in former preparation method that volatile oil is volatile, drug is unstable, effective component
The disadvantages of big is lost.
2., through ceramic membrane filter, then prepared composition discrete piece, overcoming ordinary tablet after the method for the present invention extracts square taste of traditional Chinese medicine
The problems such as disintegration and action existing for agent, capsule are slower, and dissolution rate is low, and bioavilability is lower, has disintegration rate fast, molten
Out preferably, the advantages that absorption is very fast, and onset of action is fast, and bioavilability is high, and adverse reaction is few, convenient to take, through clinical test
The result shows that product of the present invention is not clean in treatment curing postpartum bleeding, the total effective rate of young married woman's abdominal pain is up to 94% or more.
Specific embodiment
The invention will be further described combined with specific embodiments below, but does not limit the scope of the invention and apply
Range:
One, the research of extraction process
The extraction process of motherwort is studied in main other side, and the effective component of motherwort is alkaloid, is dissolved in water
And alcohol, therefore, main contrast's water mentions with alcohol extracting as a result, having investigated following several method.
1. original process
Motherwort 100g is taken, adds 10 times of amount water to decoct secondary, 2 hours for the first time, second 1 hour, filtration, filtrate was closed
And it is condensed into thick paste.
2. alcohol reflux extracts
Motherwort 100g is taken, adds 10 times of amount alcohol refluxs to extract secondary, 2 hours for the first time, second 1 hour, is filtered, filter
Liquid merges, and is condensed into thick paste.
3.50% ethanol solution refluxing extraction
Motherwort 100g is taken, adds 10 times of 50% ethanol solution refluxing extractions of amount secondary, 2 hours for the first time, 1 is small for the second time
When, filtration, filtrate merges, and is condensed into thick paste.
The rate of extract, the stachydrine hydrochloride content for measuring above-mentioned thick paste, the results are shown in Table 1.
The extraction result of 1 Different Extraction Method of table
As shown in Table 1, the stachydrine hydrochloride content difference for the thick paste that three kinds of methods are extracted is little, and the rate of extract is mentioned most with water
Height, the extraction of 50% ethanol solution are taken second place, and alcohol extracting is minimum, and the effective component in conjunction with the flavour of a drug such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger in side is mostly alcohol
Dissolubility, therefore select 50% ethanol solution refluxing extraction.
On the basis of the above comparative experiments, screening test also has been carried out to the concentration of ethanol solution, investigated 40%,
50%, the ethanol solution refluxing extraction of 60% 3 kind of various concentration as a result, being shown in Table 2.
The investigation result of 2 different concentration ethanol solution of table
As shown in Table 2,50% ethyl alcohol and 60% alcohol reflux extract the rate of extract and the content of stachydrine hydrochloride is suitable, for
The considerations of cost, selects 50% alcohol reflux to extract.
Two, the research of ceramic membrane technological parameter
1. the screening of ceramic membrane aperture
To select aperture be 0.1 μm, 0.2 μm, 0.5 μm of ceramic membrane compare research.
6 times of recipe quantity medicinal materials are taken, Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger are crushed to 30 mesh, are uniformly mixed, and the water extraction of 6 times of amounts is added to wave
Hair oil 5 hours, volatile oil is collected, the another device harvesting of the aqueous after distillation, the dregs of a decoction add 50% ethanol solution to be heated to reflux with motherwort
It extracts 3 times, first time adds 10 times amount refluxing extraction 2 hours, adds 8 times for the second time amount refluxing extraction 1.5 hours, third time adds 6 times
Amount refluxing extraction 1 hour, combined extract filter, and after filtrate recycling ethanol, merge with above-mentioned aqueous, are concentrated into crude drug: medical fluid
=1:6, obtains 16.8L, is divided into three parts, and every part of 2 recipe quantities carry out following tests respectively:
1. taking 5.6 liters of concentrate, filtered by 0.1 μm of ceramic membrane, midway adds 3 liters of purified water, collects filtered solution.
2. taking 5.6 liters of concentrate, filtered by 0.2 μm of ceramic membrane, midway adds 3 liters of purified water, collects filtered solution.
3. taking 5.6 liters of concentrate, filtered by 0.5 μm of ceramic membrane, midway adds 3 liters of purified water, collects filtered solution.
Above three parts of membrane filtration liquid is concentrated into thick paste respectively, is dried to dry cream.Measure total solid, n-butanol extract content,
Ethanol soluble extraction content, the results are shown in Table 3.
The screening of the ceramic membrane aperture of table 3
It is seen by 3 result of table, crosses that film is preferable to the retention rate of composition, and total solid is relatively low when to select aperture be 0.1 μm, therefore
Select the ceramic membrane that aperture is 0.1 μm preferably.
2, medical fluid concentration screening excessively before film
8 times of recipe quantity medicinal materials are taken, Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger are crushed to 30 mesh, are uniformly mixed, and the water extraction of 6 times of amounts is added to wave
Hair oil 5 hours, volatile oil is collected, the another device harvesting of the aqueous after distillation, the dregs of a decoction add 50% ethanol solution to be heated to reflux with motherwort
It extracts 3 times, first time adds 10 times amount refluxing extraction 2 hours, adds 8 times for the second time amount refluxing extraction 1.5 hours, third time adds 6 times
Amount refluxing extraction 1 hour, combined extract filter, and after filtrate recycling ethanol, merge with above-mentioned aqueous, carry out following examination respectively
It tests:
1. 32.3 liters of 2 times of recipe quantity filtrates is taken to be concentrated into 3.7 liters (crude drugs: medical fluid=1:4), pass through 0.1 μm of ceramic membrane filtration
It crosses, midway adds 3 liters of purified water, collects filtered solution, raffinate.
2. 32.3 liters of 2 times of recipe quantity filtrates is taken to be concentrated into 5.6 liters (crude drugs: medical fluid=1:6), pass through 0.1 μm of ceramic membrane filtration
It crosses, midway adds 3 liters of purified water, collects filtered solution, raffinate.
3. 32.3 liters of 2 times of recipe quantity filtrates is taken to be concentrated into 7.3 liters (crude drugs: medical fluid=1:8), pass through 0.1 μm of ceramic membrane filtration
It crosses, midway adds 3 liters of purified water, collects filtered solution, raffinate.
3. 32.3 liters of 2 times of recipe quantity filtrates is taken to be concentrated into 9.4 liters (crude drugs: medical fluid=1:10), pass through 0.1 μm of ceramic membrane filtration
It crosses, midway adds 3 liters of purified water, collects filtered solution, raffinate.
Membrane flux is recorded respectively, and membrane filtration liquid is concentrated into thick paste respectively, is dried to dry cream.Measure total solid, n-butanol leaches
Object content, ethanol soluble extraction content.It the results are shown in Table 4,5.
Table 4 crosses medical fluid concentration screening before film
5 membrane flux of table is investigated
Seen by result above, liquor strength is crude drug: it is slower to cross membrane flux when medical fluid=1:4, hardly possible filtration, to the guarantor of composition
There are being declined, and liquor strength is crude drug: it is very fast that medical fluid when medical fluid=1:6 or more crosses membrane flux, retains preferably composition,
Therefore extracting solution is concentrated into crude drug by selection: crossing film when medical fluid=1:6~1:10 concentration.
Three, formulation conditions screen
1. the selection of disintegrating agent
The type and dosage of disintegrating agent are most important to the disintegration of dispersible tablet, result of extraction.It selects common in dispersible tablet
Sodium carboxymethyl starch (CMS-Na), low-substituted hydroxypropyl cellulose (L-HPC), cross-linked carboxymethyl cellulose sodium (cCMC-Na), crosslinking
Polyvinylpyrrolidone (PVPP) is compared as disintegrating agent, using appearance, disintegration time limited and dispersing uniformity as evaluation index
Overall merit is carried out, to determine optimal disintegrating agent type in dispersible tablet.It the results are shown in Table 6.
The Selection experiment result table of 6 disintegrating agent of table
It was found from the test result in table 6: it is smooth as tablet surface made from disintegrating agent using L-HPC, and disintegration time limited and
Dispersing uniformity is preferable, therefore the present invention selects 20%L-HPC for disintegrating agent, is added using interior addition.
2. the selection of adhesive
Investigated in test 5% hypromellose (HPMC) ethanol solution, 5% polyethylene pyrrole alkanone K30
(PVPK30) ethanol solution, 5% polyvinylpyrrolidone (PVP) ethanol solution make adhesive, with situation of pelletizing, tablet forming and
Disintegration time limited is that evaluation index carries out overall merit, the results are shown in Table 7.
7 adhesive of table investigates result table
From in table 7: the present invention using 5%PVP ethanol solution granulation situation, tablet forming and disintegration time limited effect compared with
It is good, therefore invention adhesives select 5%PVP ethanol solution.
3. the selection of glidant
Compared in test 1% superfine silica gel powder, 1% magnesium stearate, 1% magnesium stearate-superfine silica gel powder (1: 1) as help stream
Agent, when as a result with 1% superfine silica gel powder, 1% magnesium stearate as glidant, effect is preferable, since magnesium stearate is also simultaneously
Good lubricant can guarantee the good mobility of particle, therefore the present invention selects 1% superfine silica gel powder hard as glidant, 1%
Fatty acid magnesium is as lubricant.
4. the selection of filler
Since Chinese medical extract stickiness of the present invention is larger, tabletting is relatively difficult, attempts that mannitol, crystallite fibre is added in test
Dimension element, calcium sulfate, calcium monohydrogen phosphate improve tabletting situation as filler, as a result, it has been found that tabletting when 15% calcium sulfate is added
Effect is preferable, therefore the present invention selects 15% calcium sulfate as filler.
Four, the preparation method of blood-activating and menstruation-regulating medicinal compositions
Embodiment 1
R1. motherwort, Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger are taken respectively, are cleaned, it is dry；
R2. component is weighed by following parts by weight: motherwort 1248g, Radix Angelicae Sinensis 156g, Rhizoma Chuanxiong 178g, baked ginger 78g；
R3. it takes Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger to be crushed to 30 mesh, is uniformly mixed, add the water of 6 times of amounts to extract volatile oil 5 hours, receive
Collect volatile oil, the aqueous, the dregs of a decoction after distillation are spare；
R4. the volatile oil for taking step R3 prepares volatile oil inclusion complex: by beta-cyclodextrin: volatile oil=8: the ratio of 1 (g: ml)
Example weighs beta-cyclodextrin；Add Purified Water q. s, is heated to 90 DEG C and saturated solution is made；Saturated solution is let cool to 30 DEG C,
It is slowly added to volatile oil while stirring, is maintained at 30 DEG C and stirs 2 hours, take out, let cool, seal, cold place places 6 hours and discards
Clear liquid takes out the inclusion complex that lower layer is precipitated, and filtering takes filtered inclusion complex to be dried under reduced pressure in 30 DEG C；Dry inclusion complex mistake
60 meshes, obtain inclusion complex；
R5. the dregs of a decoction of step R3 and motherwort add 50% ethanol solution heating and refluxing extraction 3 times, and for the first time plus 10 times are measured back
It flows and extracts 2 hours, add 8 times for the second time amount refluxing extraction 1.5 hours, third time adds 6 times amount refluxing extraction 1 hour, merges extraction
Liquid filters, and after filtrate recycling ethanol, merges with the aqueous of step R4, is concentrated into crude drug: medical fluid=1:6, crossing aperture is 0.1 μm
Ceramic membrane, collect filtered solution, be concentrated into thick paste, be dried under reduced pressure, get dry extract powder, crushed 100 mesh, obtains medicinal substances extract；
R6. low-substituted hydroxypropyl cellulose, superfine silica gel powder, calcium sulfate, magnesium stearate are taken respectively, and crushing sieves with 100 mesh sieve, standby
With；
R7. it is weighed by following parts by weight: low-substituted hydroxypropyl cellulose 20g, calcium sulfate 15g, superfine silica gel powder 1g, stearic acid
Magnesium 1g；
R8. it takes medicinal substances extract, low-substituted hydroxypropyl cellulose, calcium sulfate to be added in blender, is stirring evenly and then adding into
Softwood is made in 5% polyvinylpyrrolidone ethanol solution after mixing evenly, crosses the granulation of 50 mesh, dry, and step R4 is added after whole grain
Volatile oil inclusion complex, be added superfine silica gel powder, magnesium stearate, mix, tabletting to get.
Embodiment 2
R1. motherwort, Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger are taken respectively, are cleaned, it is dry；
R2. component is weighed by following parts by weight: motherwort 1248g, Radix Angelicae Sinensis 156g, Rhizoma Chuanxiong 178g, baked ginger 78g；
R3. it takes Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger to be crushed to 50 mesh, is uniformly mixed, add the water of 6 times of amounts to extract volatile oil 5 hours, receive
Collect volatile oil, the aqueous, the dregs of a decoction after distillation are spare；
R4. the volatile oil for taking step R3 prepares volatile oil inclusion complex: by beta-cyclodextrin: volatile oil=8: the ratio of 1 (g: ml)
Example weighs beta-cyclodextrin；Add Purified Water q. s, is heated to 100 DEG C and saturated solution is made；Saturated solution is let cool to 40 DEG C,
It is slowly added to volatile oil while stirring, is maintained at 40 DEG C and stirs 2 hours, take out, let cool, seal, cold place places 6 hours and discards
Clear liquid takes out the inclusion complex that lower layer is precipitated, and filtering takes filtered inclusion complex to be dried under reduced pressure in 40 DEG C；Dry inclusion complex mistake
60 meshes, obtain inclusion complex；
R5. the dregs of a decoction of step R3 and motherwort add 50% ethanol solution heating and refluxing extraction 2 times, and for the first time plus 9 times are measured back
Stream extracts 2 hours, adds 7 times for the second time amount refluxing extraction 1 hour, combined extract, filtering, after filtrate recycling ethanol, with step
The aqueous of R4 merges, and is concentrated into crude drug: medical fluid=1:8, crosses the ceramic membrane that aperture is 0.1 μm, collects filtered solution, is concentrated into thick
Cream is dried under reduced pressure, and get dry extract powder, be crushed 100 mesh, is obtained medicinal substances extract；
R6. low-substituted hydroxypropyl cellulose, superfine silica gel powder, calcium sulfate, magnesium stearate are taken respectively, and crushing sieves with 100 mesh sieve, standby
With；
R7. component is weighed by following parts by weight: low-substituted hydroxypropyl cellulose 20g, calcium sulfate 15g, superfine silica gel powder 1g, hard
Fatty acid magnesium 1g；
R8. it takes medicinal substances extract, low-substituted hydroxypropyl cellulose, calcium sulfate to be added in blender, is stirring evenly and then adding into
Softwood is made in 5% polyvinylpyrrolidone ethanol solution after mixing evenly, crosses the granulation of 50 mesh, dry, and volatile oil is added after whole grain
Inclusion complex, be added superfine silica gel powder, magnesium stearate, mix, tabletting to get.
Embodiment 3
R1. motherwort, Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger are taken respectively, are cleaned, it is dry；
R2. component is weighed by following parts by weight: motherwort 1248g, Radix Angelicae Sinensis 156g, Rhizoma Chuanxiong 178g, baked ginger 78g；
R3. it takes Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger to be crushed to 40 mesh, is uniformly mixed, add the water of 6 times of amounts to extract volatile oil 5 hours, receive
Collect volatile oil, the aqueous, the dregs of a decoction after distillation are spare；
R4. the volatile oil for taking step R3 prepares volatile oil inclusion complex: by hydroxyl beta-cyclodextrin: volatile oil=8: 1 (g: ml's)
Ratio weighs beta-cyclodextrin；Add Purified Water q. s, is heated to 95 DEG C and saturated solution is made；Saturated solution is let cool to 35
DEG C, it is slowly added to volatile oil while stirring, is maintained at 35 DEG C and stirs 2 hours, take out, let cool, seal, cold place places 6 hours and abandons
Supernatant is removed, the inclusion complex that lower layer is precipitated is taken out, filtering takes filtered inclusion complex to be dried under reduced pressure in 35 DEG C；Dry inclusion
Object crosses 60 meshes, obtains inclusion complex；
R5. the dregs of a decoction of step R3 and motherwort add 8 times of amounts 50% ethanol solution heating and refluxing extraction 2 times, and 2 hours every time,
Combined extract filters, and after filtrate recycling ethanol, merges with the aqueous of step R4, is concentrated into crude drug: medical fluid=1:10, via hole
The ceramic membrane that diameter is 0.1 μm collects filtered solution, is concentrated into thick paste, is dried under reduced pressure, get dry extract powder, crushed 100 mesh, obtains medicinal material
Extract；
R6. low-substituted hydroxypropyl cellulose, superfine silica gel powder, calcium sulfate, magnesium stearate are taken respectively, and crushing sieves with 100 mesh sieve, standby
With；
R7. component is weighed by following parts by weight: low-substituted hydroxypropyl cellulose 20g, calcium sulfate 15g, superfine silica gel powder 1g, hard
Fatty acid magnesium 1g；
R8. it takes medicinal substances extract, low-substituted hydroxypropyl cellulose, calcium sulfate to be added in blender, is stirring evenly and then adding into
Softwood is made in 5% polyvinylpyrrolidone ethanol solution after mixing evenly, crosses the granulation of 50 mesh, dry, and volatile oil is added after whole grain
Inclusion complex, be added superfine silica gel powder, magnesium stearate, mix, tabletting to get.
Five, the quality evaluation of blood-activating and menstruation-regulating medicinal compositions
1. measuring disintegration time limited
Using Chinese Pharmacopoeia version " disintegration time limit test " (general rule 0921) in 2015, Example 1-3 sample and city
It sells puerperal blood clot dispersing tablet (Film coated tablets) to be detected, records disintegration time limited respectively, the results are shown in Table 8.
8 disintegration time mensuration situation of table
By in table 8 it is found that blood-activating and menstruation-regulating medicinal compositions of the present invention are than city puerperal blood clot dispersing tablet (Film coated tablets) disintegration time limited
It is obviously shortened, it is very fast to show that it is absorbed, energy quick acting is conducive to improve curative effect.
2. measuring dissolution rate
Using Chinese Pharmacopoeia 2015 version " dissolution rate and drug release determination method " first methods (general rule 0931), Example 1-
3 sample and commercially available puerperal blood clot dispersing tablet (Film coated tablets) are detected, using high effective liquid chromatography for measuring stachydrine hydrochloride
Content, then calculate dissolution rate, the results are shown in Table 9.
9 dissolution determination situation of table
As can be seen from Table 9, blood-activating and menstruation-regulating medicinal compositions of the present invention are more molten than commercially available puerperal blood clot dispersing tablet (Film coated tablets)
Out-degree significantly improves, and shows that its bioavilability is higher.
Six, clinical test
1. data and method
1.1 general information
110 post partum lochiorrhea patients are chosen, are randomly divided into 2 groups, i.e. test group and control group, every group 55.Wherein
25~40 years old test group age, average (31.5 ± 5.5) year, the course of disease (32.5 ± 7.5) d；It is 24~39 years old control group age, average
(29.6 ± 3.20) year, the course of disease (30.8 ± 6.7) d.Two groups of patient's general information compare, no significant difference (P >
0.5) it, is comparable.
1.2 case selection
Above-mentioned case meets the diagnostic criteria of post partum lochiorrhea.Exclude hematological system disease, malignant tumour, basin
Bleeding caused by chamber infection etc..
1.3. treatment method
Test group use 3 sample treatment of the embodiment of the present invention, take orally, one time 3,3 times a day, 7 are as a treatment course.Control
Group uses commercially available puerperal blood clot dispersing tablet (conventional method preparation), oral, one time 3,3 times a day, 7 are as a treatment course.It is controlled except above-mentioned
Treatment method is outer without other drug therapies and adjuvant treatment.
1.4 observation index
Observe patient's colporrhagia amount, color, quality variation and bleeding stopping period, abdominal pain situation, uterine volume variation.
1.5 therapeutic evaluation
Observe two groups of therapeutic effects and adverse reaction situation.The standard of curative effect evaluation are as follows:
(1) fully recover: after medication, lochia < 3d stops excretion；
(2) effective: after medication, lochia < 5d stops excretion；
(4) effectively: after medication, lochia < 7d stops；
(3) invalid: after medication, lochia > 7d does not stop yet.
1.6 statistical procedures
Data processing and analysis are carried out using 22.0 statistical software of SPSS, while being examined using t, as P < 0.05, is shown
Difference is statistically significant.
2. result
2.1 adverse reactions and safety evaluatio
In therapeutic process, two groups of patients do not occur adverse reaction.
2.2 Clinical efficacy comparison
It the results are shown in Table 10-12.
10 two groups of Clinical efficacy comparisons (example) of table
Note: compared with the control group,*P < 0.05.
Symptom improvement situation compares (x ± s) after 11 two groups of patient's treatments of table
Note: compared with the control group,*P < 0.05.
12 two groups of patient uterine's restoration of old ways situations of table compare (x ± s)
Note: compared with the control group,*P < 0.05.
3. conclusion
The above clinical test results show 3 sample of embodiment produced through preparation method of the present invention in treatment curing postpartum bleeding
It is not better than control group in net effect, illustrates that its treatment not clean to curing postpartum bleeding has a better effect, and takes safe and reliable, nothing
Adverse reaction side effect.
Claims (10)
1. a kind of blood-activating and menstruation-regulating medicinal compositions, raw material are mainly grouped as by the group of following parts by weight: 1248 parts of motherwort, when
Return 156 parts, 178 parts of Rhizoma Chuanxiong, 78 parts of baked ginger, which is characterized in that preparation method includes the following steps:
R1. motherwort, Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger are taken respectively, are cleaned, it is dry；
R2. component is weighed by following parts by weight: 1248 parts of motherwort, 156 parts of Radix Angelicae Sinensis, 178 parts of Rhizoma Chuanxiong, 78 parts of baked ginger；
R3. it takes Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger to be crushed to 30~50 mesh, is uniformly mixed, extract volatile oil, volatile oil is collected, after distillation
Aqueous, the dregs of a decoction it is spare；
R4. the volatile oil for taking step R3 prepares volatile oil inclusion complex；
R5. the dregs of a decoction of step R3 and motherwort add ethanol solution refluxing extraction, filter, after filtrate recycling ethanol, with step R4's
Aqueous merges, and ceramic membrane is crossed in concentration, is collected filtered solution, is concentrated into thick paste, is dried under reduced pressure, and get dry extract powder, and crushing sieves with 100 mesh sieve,
Obtain medicinal substances extract；
R6. low-substituted hydroxypropyl cellulose, superfine silica gel powder, calcium sulfate, magnesium stearate are taken respectively, and crushing sieves with 100 mesh sieve, spare；
R7. component is weighed by following parts by weight: 20 parts of low-substituted hydroxypropyl cellulose, 15 parts of calcium sulfate, 1 part of superfine silica gel powder, hard
1 part of fatty acid magnesium；
R8. it takes medicinal substances extract, low-substituted hydroxypropyl cellulose, calcium sulfate to be added in blender, it is poly- to be stirring evenly and then adding into 5%
Softwood is made in vinylpyrrolidone ethanol solution after mixing evenly, crosses the granulation of 50 mesh, dry, and waving for step R4 is added after whole grain
Hair oil inclusion complex, be added superfine silica gel powder, magnesium stearate, mix, tabletting to get.
2. blood-activating and menstruation-regulating medicinal compositions according to claim 1, which is characterized in that preparation methods steps R3 extraction is waved
The method of hair oil is plus the water of 6 times of amounts extracts volatile oil 5 hours.
3. blood-activating and menstruation-regulating medicinal compositions according to claim 1, which is characterized in that described in step R5 plus ethanol solution returns
Stream be extracted as plus 6~10 times amount 50% ethanol solution heating and refluxing extraction 2~3 times, every time 1~2 hour.
4. blood-activating and menstruation-regulating medicinal compositions according to claim 1, which is characterized in that preparation methods steps R5, which is concentrated, is
Be concentrated into crude drug: medical fluid=1:6~1:10, ceramic membrane are the ceramic membrane that aperture is 0.1 μm.
5. blood-activating and menstruation-regulating medicinal compositions according to claim 1, which is characterized in that preparation methods steps R4 preparation is waved
The method of hair oil inclusion complex are as follows:
S1. in beta-cyclodextrin: volatile oil=8: the ratio of 1 (g: ml) weighs beta-cyclodextrin；
S2. plus Purified Water q. s, it is heated to 90 DEG C~100 DEG C and saturated solution is made；
S3. saturated solution is let cool to 30 DEG C~40 DEG C, is slowly added to volatile oil while stirring, be maintained at 30 DEG C~40 DEG C stirrings
It 2 hours, takes out, lets cool, seal, cold place is placed 6 hours；
S4. liquid is discarded supernatant, the inclusion complex that lower layer is precipitated is taken out, filtering takes filtered inclusion complex to depressurize in 30 DEG C~40 DEG C
It is dry；
S5. dry inclusion complex crosses 60 meshes, obtains inclusion complex.
6. a kind of preparation method of blood-activating and menstruation-regulating medicinal compositions as described in claim 1, which is characterized in that including following step
It is rapid:
R1. motherwort, Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger are taken respectively, are cleaned, it is dry；
R2. component is weighed by following parts by weight: 1248 parts of motherwort, 156 parts of Radix Angelicae Sinensis, 178 parts of Rhizoma Chuanxiong, 78 parts of baked ginger；
R3. it takes Radix Angelicae Sinensis, Rhizoma Chuanxiong and baked ginger to be crushed to 30~50 mesh, is uniformly mixed, extract volatile oil, volatile oil is collected, after distillation
Aqueous, the dregs of a decoction it is spare；
R4. the volatile oil for taking step R3 prepares volatile oil inclusion complex；
R5. the dregs of a decoction of step R3 and motherwort add ethanol solution refluxing extraction, filter, after filtrate recycling ethanol, with step R4's
Aqueous merges, and ceramic membrane is crossed in concentration, collects filtered solution, is concentrated into thick paste, is dried under reduced pressure, get dry extract powder, crushed 100 mesh, obtains
Medicinal substances extract；
R6. low-substituted hydroxypropyl cellulose, superfine silica gel powder, calcium sulfate, magnesium stearate are taken respectively, and crushing sieves with 100 mesh sieve, spare；
R7. component is weighed by following parts by weight: 20 parts of low-substituted hydroxypropyl cellulose, 15 parts of calcium sulfate, 1 part of superfine silica gel powder, hard
1 part of fatty acid magnesium；
R8. it takes medicinal substances extract, low-substituted hydroxypropyl cellulose, calcium sulfate to be added in blender, it is poly- to be stirring evenly and then adding into 5%
Softwood is made in vinylpyrrolidone ethanol solution after mixing evenly, crosses the granulation of 50 mesh, dry, and waving for step R4 is added after whole grain
Hair oil inclusion complex, be added superfine silica gel powder, magnesium stearate, mix, tabletting to get.
7. blood-activating and menstruation-regulating medicinal compositions according to claim 6, which is characterized in that preparation methods steps R3 extraction is waved
The method of hair oil is plus the water of 6 times of amounts extracts volatile oil 5 hours.
8. blood-activating and menstruation-regulating medicinal compositions according to claim 6, which is characterized in that described in step R5 plus ethanol solution returns
Stream be extracted as plus 6~10 times amount 50% ethanol solution heating and refluxing extraction 2~3 times, every time 1~2 hour.
9. blood-activating and menstruation-regulating medicinal compositions according to claim 6, which is characterized in that preparation methods steps R5, which is concentrated, is
Be concentrated into crude drug: medical fluid=1:6~1:10, ceramic membrane are the ceramic membrane that aperture is 0.1 μm.
10. blood-activating and menstruation-regulating medicinal compositions according to claim 6, which is characterized in that preparation methods steps R4 preparation
The method of volatile oil inclusion complex are as follows:
S1. in beta-cyclodextrin: volatile oil=8: the ratio of 1 (g: ml) weighs beta-cyclodextrin；
S2. plus Purified Water q. s, it is heated to 90 DEG C~100 DEG C and saturated solution is made；
S3. saturated solution is let cool to 30 DEG C~40 DEG C, is slowly added to volatile oil while stirring, be maintained at 30 DEG C~40 DEG C stirrings
It 2 hours, takes out, lets cool, seal, cold place is placed 6 hours；
S4. liquid is discarded supernatant, the inclusion complex that lower layer is precipitated is taken out, filtering takes filtered inclusion complex to depressurize in 30 DEG C~40 DEG C
It is dry；
S5. dry inclusion complex crosses 60 meshes, obtains inclusion complex.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101850100A (en) * | 2010-06-01 | 2010-10-06 | 烟台大洋制药有限公司 | Preparation method of puerperal blood stasis dissipating tablets |
| CN104740582A (en) * | 2015-04-13 | 2015-07-01 | 翔宇药业股份有限公司 | Pharmaceutical preparation for removing blood stasis after delivery as well as detection and detection method for pharmaceutical preparation |
-
2019
- 2019-08-20 CN CN201910769349.4A patent/CN110302353A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101850100A (en) * | 2010-06-01 | 2010-10-06 | 烟台大洋制药有限公司 | Preparation method of puerperal blood stasis dissipating tablets |
| CN104740582A (en) * | 2015-04-13 | 2015-07-01 | 翔宇药业股份有限公司 | Pharmaceutical preparation for removing blood stasis after delivery as well as detection and detection method for pharmaceutical preparation |
Non-Patent Citations (2)
| Title |
|---|
| 李逢菊等: ""β-环糊精包合芪精镇痛颗粒中挥发油工艺研究"", 《中国中医药科技》 * |
| 林凡友等: "复方益母胶囊的提取工艺研究", 《齐鲁药事》 * |
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