CN110301931B - Coordinate registration die body, multi-mode imaging system and image registration method thereof - Google Patents
Coordinate registration die body, multi-mode imaging system and image registration method thereof Download PDFInfo
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Abstract
The present disclosure provides a coordinate registration phantom, a multi-modality imaging system, and an image registration method thereof, which belong to the field of medical instruments. The coordinate registration phantom includes a support and a plurality of phantoms. The support comprises a first support rod, a second support rod intersected with the first support rod, and at least three third support rods with the extending direction intersected with the extending direction of the first support rod and the extending direction intersected with the second support rod, wherein the second support rod is connected with the third support rods, and the at least two third support rods are arranged along the second support rods in a separated mode. At least two die bodies in the plurality of die bodies are separately arranged on the first supporting rod, at least three die bodies are arranged on at least three third supporting rods, and at least two die bodies are separately arranged along the extending direction of the third supporting rods. The die body comprises a cavity for containing radioactive substances and a through hole communicated with the cavity, and the through hole is arranged on the top wall of the body. The coordinate registration die body has the advantages of simple structure, convenience and flexibility in installation, large scanned range and contribution to accurately registering images.
Description
Technical Field
The present disclosure relates to the field of medical devices, and in particular, to a coordinate registration phantom, a multi-modality imaging system, and an image registration method thereof.
Background
The multi-modality imaging system includes a plurality of different detectors that combine the respective advantages of the plurality of imaging modalities to facilitate accurate determination of the location of a lesion in a patient. For example, PET-CT (Positron Emission Tomography-Computed Tomography), positron emission tomography-X-ray computed tomography) devices include PET detectors and CT detectors. However, due to the different mounting modes of the PET detector and the CT detector, the imaging positions of the same detection part in the imaging field of view are easily different, which is not beneficial to determining the focus position. The coordinate registration die body is adopted to determine the deviation of the scanning visual field of the PET detector and the scanning visual field of the CT detector, and is favorable for registering the PET image and the CT image so that the imaging position of the same detection part in the imaging visual field is the same, and the fusion of the PET image and the CT image is realized.
Disclosure of Invention
The coordinate registration die body, the multi-mode imaging system and the image registration method thereof have the advantages of simple structure, convenience and flexibility in installation and large scanned range.
One aspect of the present disclosure provides a coordinate registration phantom for a multi-modality imaging system, the coordinate registration phantom comprising:
a stent, comprising: the device comprises a first supporting rod, a second supporting rod intersected with the first supporting rod, and at least three third supporting rods with the extending direction intersected with the extending direction of the first supporting rod and the extending direction intersected with the second supporting rod, wherein the second supporting rod is connected with the third supporting rods, and at least two third supporting rods are arranged along the second supporting rods in a separated mode; a kind of electronic device with high-pressure air-conditioning system
The mold bodies are separately arranged on the first supporting rods, the mold bodies are arranged on the third supporting rods, and the mold bodies are separately arranged along the extending direction of the third supporting rods; the die body comprises: a body, the body comprising: the cavity is used for containing radioactive substances and is communicated with the through hole of the cavity, and the through hole is formed in the top wall of the body.
Optionally, a first groove recessed inwards is formed in the top wall of the body, and the through hole penetrates through the bottom wall of the first groove.
Optionally, the side walls of the first recess gradually shrink inwardly in a direction pointing towards the cavity.
Optionally, the bottom wall of the body is provided with a second groove symmetrical to the first groove.
Optionally, the material of the body comprises organic glass; the radioactive material includes an F18 radioactive material.
Optionally, at least two third support bars are respectively arranged at two sides of one end of the first support bar, and the end part of at least one third support bar is connected with the other end of the second support bar.
Optionally, the middle part of the first support rod is vertically connected with the middle part of the second support rod;
and the end parts of at least three third support rods are vertically connected with the second support rods.
Optionally, the two ends of the first support rod are both provided with the die body, and at least three ends of the third support rod, which deviate from the second support rod, are both provided with the die body.
Another aspect of the present disclosure provides a multi-modality imaging system, the multi-modality imaging system comprising:
a scanning bed;
a first detector comprising a first scan field of view and a second detector comprising a second scan field of view, the scanning bed being movable into the first and second scan fields of view;
a coordinate registration phantom as described in any of the above references, disposed on the scanning bed; a kind of electronic device with high-pressure air-conditioning system
The processor is electrically connected with the first detector and the second detector and is used for: acquiring first space coordinates of the coordinate registration die body in the first scanning view; acquiring second space coordinates of the coordinate registration die body in the second scanning view field; determining a first parameter deviation value between the first scan field of view and the second scan field of view according to the first spatial coordinates and the second spatial coordinates; and adjusting the position of the second detector according to the first parameter deviation value to enable the second scanning visual field to be in registration with the first scanning visual field.
Optionally, an included angle is formed between the projection of the axis of the first support rod of the coordinate registration die body on the scanning bed and the axis of the scanning bed, and the included angle is an acute angle or a right angle.
Another aspect of the present disclosure provides a method of image registration for a multi-modality imaging system for use in any of the above-mentioned multi-modality imaging systems, the method comprising:
acquiring first space coordinates of a coordinate registration die body in a first scanning view of a first detector;
acquiring second space coordinates of the coordinate registration die body in a second scanning view of a second detector;
determining a first parameter deviation value between the first scan field of view and the second scan field of view according to the first spatial coordinates and the second spatial coordinates;
and adjusting the position of the second detector according to the first parameter deviation value to enable the second scanning visual field to be in registration with the first scanning visual field.
Optionally, the method further comprises:
determining a second parameter deviation value between the scanning bed and the first scanning field of view according to the first spatial coordinates and the second spatial coordinates;
and adjusting the position of the scanning bed according to the second parameter deviation value to enable the scanning bed to be in registration with the first scanning visual field.
The coordinate registration die body provided by the embodiment of the disclosure has at least the following beneficial effects:
the coordinate registration die body provided by the embodiment of the disclosure enables the bracket to be three-dimensional through the intersection of the first supporting rod and the second supporting rod in the bracket and the intersection of the extending directions of at least three third supporting rods and the extending directions of the first supporting rod and the second supporting rod, and the bracket is simple in structure. At least two of the plurality of die bodies are arranged on the first supporting rod in a separated mode, at least three of the plurality of die bodies are arranged on at least three of the third supporting rods in a separated mode, and at least two of the die bodies are arranged on different positions of the support in a separated mode, so that the scanned range of the coordinate registration die body is enlarged, and the coordinate registration die body is used for accurately registering images. The through hole is arranged on the top wall of the die body, so that radioactive substances can be conveniently injected, and a sealing piece is not required to be arranged, thereby being beneficial to weight reduction and installation of the die body. The coordinate registration die body has simple structure, is convenient to produce and manufacture and flexible to install and use, can expand the scanned range, and is favorable for accurately registering images.
Drawings
FIG. 1 is a schematic diagram illustrating a configuration of a multi-modality imaging system according to an exemplary embodiment of the present disclosure;
FIG. 2 is a schematic diagram illustrating a coordinate registration phantom according to an exemplary embodiment of the present disclosure;
FIG. 3 is a schematic view of a mold body according to an exemplary embodiment of the present disclosure;
FIG. 4 is a flowchart illustrating an image registration method of a multi-modality imaging system according to an exemplary embodiment of the present disclosure;
FIG. 5 illustrates a setpoint profile of a multi-modality imaging system according to an exemplary embodiment of the present disclosure.
Detailed Description
Reference will now be made in detail to exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, the same numbers in different drawings refer to the same or similar elements, unless otherwise indicated. The implementations described in the following exemplary examples are not representative of all implementations consistent with the present disclosure. Rather, they are merely examples of apparatus and methods consistent with some aspects of the present disclosure as detailed in the accompanying claims.
The terminology used in the present disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. Unless defined otherwise, technical or scientific terms used in this disclosure should be given the ordinary meaning as understood by one of ordinary skill in the art to which this disclosure belongs. The terms "first," "second," and the like in the description and in the claims, are not used for any order, quantity, or importance, but are used for distinguishing between different elements. Likewise, the terms "a" or "an" and the like do not denote a limitation of quantity, but rather denote the presence of at least one. Unless otherwise indicated, the terms "comprises," "comprising," and the like are intended to cover the presence of elements or articles recited as being "comprising" or "including," and equivalents thereof, without excluding other elements or articles. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.
As used in this disclosure and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any or all possible combinations of one or more of the associated listed items.
In some embodiments, the coordinate registration phantom includes: the developer cartridge includes a base, a housing, a seal cap, and a plurality of test tubes containing developer. The base is connected with one end of the shell, the shell comprises an open cavity, the sealing cover is covered in the open cavity, and the sealing cover and the shell form a sealing cavity. The sealing cover is provided with a plurality of mounting holes, and a plurality of test tubes pass through the mounting holes side by side and extend into the sealing cavity. The coordinate registration phantom may be used in a multi-modality imaging system. However, the coordinate registration die body has a complex structure, cannot be flexibly installed at different positions in the multi-mode imaging system, and a plurality of test tubes are arranged side by side, so that the scanned range of the coordinate registration die body in the multi-mode imaging system is small, and accurate image registration is not facilitated. Based on the above, the embodiment of the disclosure provides a coordinate registration phantom, a multi-modal imaging system and an image registration method thereof.
The embodiment of the disclosure provides a coordinate registration die body, which is used in a multi-mode imaging system and comprises: a bracket and a plurality of die bodies. Wherein, the support includes: the support comprises a first support rod, a second support rod intersected with the first support rod, and at least three third support rods with the extending direction intersected with the extending direction of the first support rod and the extending direction intersected with the second support rod, wherein the second support rod is connected with the third support rods, and at least two third support rods are arranged along the second support rod in a separated mode. At least two die bodies in the plurality of die bodies are separately arranged on the first supporting rod, at least three die bodies are arranged on at least three third supporting rods, and at least two die bodies are separately arranged along the extending direction of the third supporting rods. The die body comprises: the body, the body includes: the through hole is arranged on the top wall of the body and is used for accommodating the cavity of the radioactive substance and communicating the cavity. The coordinate registration die body provided by the embodiment of the disclosure enables the bracket to be three-dimensional through the intersection of the first supporting rod and the second supporting rod in the bracket and the intersection of the extending directions of at least three third supporting rods and the extending directions of the first supporting rod and the second supporting rod, and the bracket is simple in structure. At least two of the plurality of die bodies are arranged on the first supporting rod in a separated mode, at least three of the plurality of die bodies are arranged on at least three of the third supporting rods in a separated mode, and at least two of the die bodies are arranged on different positions of the support in a separated mode, so that the scanned range of the coordinate registration die body is enlarged, and the coordinate registration die body is used for accurately registering images. The through hole is arranged on the top wall of the die body, so that radioactive substances can be conveniently injected, and a sealing piece is not required to be arranged, thereby being beneficial to weight reduction and installation of the die body. The coordinate registration die body has simple structure, is convenient to produce and manufacture and flexible to install and use, can expand the scanned range, and is favorable for accurately registering images.
Fig. 1 is a schematic diagram illustrating a multi-modality imaging system according to an exemplary embodiment of the present disclosure, and referring to fig. 1, the multi-modality imaging system includes: a scan bed 1, a first detector 2, a second detector 3, a coordinate registration phantom 4, a processor (not shown). Wherein the first detector 2 comprises a first scanning field of view and the second detector 3 comprises a second scanning field of view, and the scanning bed 1 is movable into the first scanning field of view and the second scanning field of view. The coordinate registration phantom 4 is disposed on the scanner bed 1. The processor is electrically connected with the first detector 2 and the second detector 3, and the processor is used for: acquiring first space coordinates of a die body in the first scanning visual field in the coordinate registration die body 4; acquiring second space coordinates of the die body in the second scanning view in the coordinate registration die body 4; determining a first parameter deviation value between the first scanning visual field and the second scanning visual field according to the first space coordinate and the second space coordinate; and adjusting the position of the second detector 3 according to the first parameter deviation value to enable the second scanning visual field to be registered with the first scanning visual field.
It should be noted that the scanning ranges of the first scanning field of view and the second scanning field of view may be the same or different, and the coordinate registration phantom 4 is applicable to the first scanning field of view and the second scanning field of view.
The first detector 2 may be an electron computed tomography (Computed Tomography, CT) device, and the second detector 3 may be a positron emission computed tomography (Positron Emission Tomography, PET) device. Alternatively, the first detector 2 may be a PET device and the second detector 3 may be a CT device. The first detector 2 and the second detector 3 may also be other image detectors, which are not particularly limited in the embodiments of the present disclosure.
The coordinate registration phantom 4 may be positioned at the head of the scanner bed 1 such that the coordinate registration phantom 4 may be moved into the first and second scan fields of view as the scanner bed 1 is moved. By using the coordinate registration phantom 4, the first scan field of view and the second scan field of view can be registered, i.e., the origin of coordinates of the first scan field of view coincides with the origin of coordinates of the second scan field of view, and the x-axis, y-axis, and z-axis of the first scan field of view coincide with the x-axis, y-axis, and z-axis of the second scan field of view, respectively.
Fig. 2 is a schematic diagram of a coordinate registration phantom 4 according to an exemplary embodiment of the present disclosure, the coordinate registration phantom 4 being used in a multi-modality imaging system. Referring to fig. 2, the coordinate registration phantom 4 includes: a bracket 41 and a plurality of die bodies 42. Wherein the bracket 41 includes: the first support bar 411, the second support bar 412 intersecting the first support bar 411, and at least three third support bars 413 whose extending directions intersect the extending directions of the first support bar 411 and intersect the extending directions of the second support bar 412, the second support bar 412 is connected with the third support bars 413, and at least two third support bars 413 are separately arranged along the second support bar 412. At least two mold bodies 42 of the plurality of mold bodies 42 are separately arranged on the first supporting rod 411, at least three mold bodies 42 are arranged on at least three third supporting rods 413, and at least two mold bodies 42 are separately arranged along the extending direction of the third supporting rods 413.
In one embodiment, with continued reference to fig. 2, at least two third support rods 413 are respectively disposed on two sides of one end of the second support rod 412, and an end of at least one third support rod 413 is connected to the other end of the second support rod 412, which makes the structure of the support 41 regular, and facilitates the manufacturing, installation and use of the support 41. At least two third support bars 413 disposed on both sides of one end of the second support bar 412 may or may not be opposite to each other.
In one embodiment, with continued reference to FIG. 2, the middle of the first support bar 411 is perpendicularly joined to the middle of the second support bar 412; the ends of at least three third support bars 413 are vertically connected to the second support bar 412. In this way, the structure of the support 41 is simple, the production and manufacture are convenient, and the plurality of mold bodies 42 can be respectively arranged on the support 41 in a extending manner in the transverse direction, the longitudinal direction and the front-rear direction, so that the scanning range of the coordinate registration mold body 4 is enlarged. The first support rod 411 is detachably connected to the second support rod 412, and the second support rod 412 is detachably connected to the third support rod 413, such as a clamping connection. The lengths of the first support bar 411, the second support bar 412 and the third support bar 413 are all adjustable, so that the coordinate registration phantom 4 is suitable for different scanning fields of view.
In one embodiment, with continued reference to fig. 2, the first support bar 411 is provided with a mold body 42 at both ends and the at least three third support bars 413 are provided with mold bodies 42 at the ends facing away from the second support bar 412. In this manner, it is advantageous to increase the extent to which the coordinate registration phantom 4 is scanned by the multi-modality imaging system. For example, the multi-modality imaging system includes a cylindrical scan field of view having a circular cross section perpendicular to the axial direction, the mold bodies 42 at the two ends of the first support rod 411 may be adjacent to the circular lateral edges, and the mold bodies 42 at the ends of the at least two third support rods 413 may be adjacent to the circular longitudinal edges to expand the range of the coordinate registration mold body 4 scanned in the scan field of view.
In one embodiment, with continued reference to fig. 2, the coordinate registration phantom 4 includes: a first support bar 411, a second support bar 412 and three third support bars 413. The middle part of the first supporting rod 411 is vertically connected with the middle part of the second supporting rod 412, two third supporting rods 413 are vertically connected with the upper ends of the second supporting rods 412, and are arranged on two sides of the second supporting rods 412, and one third supporting rod 413 is vertically connected with the lower ends of the second supporting rods 412. The coordinate registration phantom 4 has a simple structure and is conveniently and flexibly arranged at different positions of the scanning bed 1 in the multi-mode system.
In the disclosed embodiment, the mold body 42 may be secured to the support 41 by fasteners, such as by clamping the mold body 42 to the support 41. The fixing member may include: the cover plate covers the die body 42 and the screws penetrate through the cover plate to be in threaded connection with the support 41. In another embodiment, the bracket 41 is provided with a clamping groove, and the die body 42 is clamped in the clamping groove.
Fig. 3 is a schematic diagram illustrating a construction of a mold body 42 according to an exemplary embodiment of the present disclosure. In one embodiment, referring to FIG. 3, the mold body 42 includes: the body 421, the body 421 includes: a cavity 422 for containing radioactive substances and a through hole 423 communicating with the cavity 422, the through hole 423 being provided on the top wall of the body 421. The through hole 423 is arranged on the top wall of the body 421, so that the radioactive substances contained in the cavity 422 of the body 421 can be reduced to be sputtered out by the through hole 423, and a sealing piece for sealing the through hole 423 is not required, thereby facilitating weight reduction and installation of the die body 42, and the die body 42 has a simple structure and is convenient to manufacture and use. The body 421 may have a regular or irregular structure such as a square body or a column body. The material of the body 421 includes organic glass or transparent plastic, so as not to affect the scanning of radioactive substances. The radioactive material includes F18 radioactive material such as F18-FDG (2-Fluoro-18 Fluoro-2-deoxy-D-glucose) solution, which is readily available. The plurality of mold bodies 42 are separately arranged on the support 41, so that compared with a test tube provided with radioactive substances, the scanning range is enlarged, the use amount of the radioactive substances is reduced, and the cost is reduced.
The coordinate registration mold body 4 provided in the embodiment of the present disclosure makes the support 41 three-dimensional by intersecting the first support bar 411 and the second support bar 412 in the support 41 and intersecting the extending direction of the first support bar 411 and the extending direction of the second support bar 412 with the extending direction of at least three third support bars 413, and the support 41 has a simple structure. At least two of the plurality of mold bodies 42 are separately arranged on the first support rod 411, at least three of the mold bodies 42 are arranged on at least three of the third support rods 413, and at least two of the mold bodies 42 are separately arranged along the extending direction of the third support rods 413, so that the plurality of mold bodies 42 are separately arranged at different positions of the support 41, the scanned range of the coordinate registration mold body 4 is enlarged, and the coordinate registration mold body 4 is used for accurately registering images. The through hole 423 is arranged on the top wall of the body 421 of the die body 42, so that radioactive substances can be conveniently injected, and a sealing piece can be omitted, thereby being beneficial to weight reduction and installation of the die body 42. The coordinate registration die body 4 has a simple structure, is convenient to produce and manufacture, is flexibly installed and used, can expand the scanned range, and is favorable for accurately registering images.
In one embodiment, with continued reference to fig. 3, the top wall of the body 421 is provided with an inwardly recessed first recess 424, and the through hole 423 penetrates the bottom wall of the first recess 424. The radioactive materials sputtered from the through holes 423 can be collected in the first grooves 424 and re-enter the through holes 423, so as to avoid polluting the outside.
In one embodiment, with continued reference to fig. 3, the sidewalls of the first recess 424 gradually contract inwardly in a direction toward the cavity 422 to facilitate the accumulation of the radioactive material within the first recess 424 and re-enter the through hole 423. The cross-section of the first groove 424 may be square, circular, and other regular or irregular structures, which are not particularly limited in the embodiments of the present disclosure.
In one embodiment, with continued reference to FIG. 3, the bottom wall of the body 421 is provided with a second recess 425 symmetrical to the first recess 424 to provide symmetry to the structure of the body 421 to act as a source of regular points in use to facilitate determining the spatial coordinates of the center of gravity of the mold body 42. For example, the spatial coordinates of the phantom 42 may be defined as the spatial coordinates of the phantom 42 where the center of gravity of the phantom 42 is located.
In one embodiment, the axis of the first support rod 411 of the coordinate registration die body 4 forms an included angle between the projection of the axis of the first support rod 411 onto the scan bed 1 and the axis of the scan bed 1, and the included angle is an acute angle or a right angle. The coordinate registration die body 4 can be installed on the scanning bed 1 at different projection angles, and has flexible installation position and convenient use. The coordinate registration mold body 4 is detachably connected with the scanning bed 1, for example, a slot is arranged on the scanning bed 1, the slot is positioned on the central axis of the scanning bed 1, and the bracket 41 is detachably inserted into the slot. For another example, the scanning bed 1 is provided with a first clamping piece, the bracket 41 is provided with a second clamping piece, and the second clamping piece is in clamping connection with the first clamping piece, so that the coordinate registration die body 4 is clamped on the scanning bed 1. It should be noted that the first clamping member and the second clamping member do not cause image artifacts. The present disclosure is not particularly limited with respect to the structures of the first clamping member and the second clamping member.
The multi-modality imaging system provided in the embodiments of the present disclosure includes any of the above-mentioned coordinate registration phantom 4, where the coordinate registration phantom 4 is convenient and flexible to be installed at different positions of the multi-modality imaging system, and can expand the scanned range, so as to facilitate the multi-modality imaging system to accurately register images.
Fig. 4 is a flowchart illustrating an image registration method of a multi-modality imaging system according to an exemplary embodiment of the present disclosure, for use in the multi-modality imaging system mentioned above. Referring to fig. 4, the method includes:
step 101, acquiring first spatial coordinates of the phantom 42 in the coordinate registration phantom 4 in a first scan field of view of the first detector 2.
The scanning bed 1 is controlled to move into a first scanning view of the first detector 2, so that the first detector 2 scans the coordinate registration die body 4 to obtain a first reconstructed image of the coordinate registration die body 4, and the first reconstructed image is processed by the processor to obtain first space coordinates of each die body 42 in the coordinate registration die body 4. For example, a first spatial coordinate of the center of gravity of each phantom 42 is obtained. Wherein the first spatial coordinates may be expressed as (x 1, y1, z 1), x1 representing coordinates of the phantom 42 in a transverse x-axis of the first scan field of view, y1 representing coordinates of the phantom 42 in a fore-aft y-axis of the first scan field of view, and z1 representing coordinates in a longitudinal z-axis of the first scan field of view. The origin of coordinates is the center point of the first scan field of view.
Step 102, obtaining second spatial coordinates of the phantom 42 in the coordinate registration phantom 4 in the second scan field of view of the second detector 3.
The scanning bed 1 is controlled to move into a second scanning visual field of the second detector 3, so that the second detector 3 scans the coordinate registration die body 4 to obtain a second reconstructed image of the coordinate registration die body 4, and the second reconstructed image is processed by the processor to obtain second space coordinates of each die body 42 in the coordinate registration die body 4. For example, a second spatial coordinate of the center of gravity of each phantom 42 is obtained. Wherein the second spatial coordinates may be expressed as (x 2, y2, z 2), x2 representing coordinates of the phantom 42 in a transverse x-axis of the second scan field of view, y2 representing coordinates of the phantom 42 in a fore-aft y-axis of the second scan field of view, and z2 representing coordinates of the phantom 42 in a longitudinal z-axis of the second scan field of view. The origin of coordinates is the center point of the second scan field of view.
Step 103, determining a first parameter deviation value between the first scanning visual field and the second scanning visual field according to the first space coordinate and the second space coordinate. The first parameter bias value includes: the spatial coordinate system of the first scan field of view corresponds to the translational and angular offset values of coordinates x, y, z of the spatial coordinate system of the second scan field of view.
Taking the first detector as a CT detector and the second detector as a PET detector as an example, determining a first parameter deviation value of the first scanning visual field and the second scanning visual field comprises the following steps:
step a, according to equation I and the transformation matrix M, the second spatial coordinates (x PET ，y PET ，z PET ) Converts into a third spatial coordinate (x 'in the first scan field of view' CT ，y′ CT ，z′ CT )。
(x′ CT ，y′ CT ，z′ CT )＝M×(x PET ，y PET ，z PET ) (formula I)
Step b, calculating the first spatial coordinates (x CT ，y CT ，z CT ) With a third spatial coordinate (x' CT ，y′ CT ，z′ CT ) Is a coordinate deviation expression of (2).
F＝(x CT ，y CT ，z CT )-(x′ CT ，y′ CT ，z′ CT ) (formula II)
And c, converting the formula II into an optimal solution for solving the following formula III according to a least square method.
Wherein, (x) CT ，y CT ，z CT ) The center of gravity coordinates of the phantom 42 in the first scan field of view,(x PET ，y PET ，z PET ) For the barycentric coordinates of the phantom 42 in the second scan field of view, i=1, … …, N, indicates the number of phantom 42 in the coordinate registration phantom 4, F T Is the transposed matrix of F.
And d, obtaining a conversion matrix M according to the optimal solution of E, and further determining translational deviation and angular deviation of x, y and z in the coordinate system of the PET scanning visual field to the coordinate system of the CT scanning visual field.
Step 104, adjusting the position of the second detector 3 according to the first parameter deviation value, so as to register the second scan field with the first scan field.
In one embodiment, the image registration method of the multi-modality imaging system provided in the embodiment of the present disclosure further includes:
step 105, determining a second parameter deviation value between the scanning bed 1 and the first scanning field according to the first space coordinate and the second space coordinate. The second parameter bias value includes: translational misalignment between the scan table 1 and the first scan field of view coordinate system, and angular misalignment between the scan table 1 and the x-axis and the y-axis in the first scan field of view coordinate system.
By locating the coordinate registration phantom 4 on the central axis of the couch 1 and locating at least one phantom 42 on the central axis of the couch 1, a translational offset value between the couch 1 and the first scan field of view coordinate system is determined based on the first spatial coordinates of the phantom 42. An offset angle between the scan bed 1 and the first scan field of view is determined based on the first and second spatial coordinates of the phantom 42.
And 106, adjusting the position of the scanning bed 1 according to the second parameter deviation value to enable the scanning bed 1 to be in registration with the first scanning visual field. By registering the scanning bed 1 with the first scanning field of view, accurate determination of lesions is facilitated.
According to the image registration method of the multi-mode imaging system provided by the embodiment of the disclosure, the first space coordinates of the die body 42 in the first scanning visual field and the second space coordinates in the second scanning visual field in the coordinate registration die body 4 are obtained, the first parameter deviation value between the first scanning visual field and the second scanning visual field is determined according to the first space coordinates and the second space coordinates, and then the position of the second detector 3 is adjusted according to the first parameter deviation value, so that the second scanning visual field is registered with the first scanning visual field. The coordinate registration die body 4 has a simple structure, can be conveniently and flexibly arranged at different positions of the multi-mode imaging system, is convenient for implementation of the method, has a large scanning range of the coordinate registration die body 4, and is favorable for accurately carrying out image registration by the image registration method.
The order of steps 103 to 104 and steps 105 to 106 is not particularly limited, and images may be registered.
In one embodiment, step 104 and step 106 comprise:
the processor outputs a translational deviation value and an angular deviation value of the adjusting point of the second detector 3 in the second scanning visual field and the first scanning visual field according to the first parameter deviation value and the second parameter deviation value, and the translational deviation value and the angular deviation value between the adjusting point of the scanning bed 1 and the first scanning visual field are specifically shown in table 1. Wherein the setpoint profile of the multi-modality imaging system according to an exemplary embodiment is shown with reference to the present disclosure shown in fig. 5 for the setpoint of the second detector 3 and the scanning bed 1. Referring to fig. 5, the adjustment points of the second probe 3 include: g1, G2, G3, G4, G5, G6, G7, GA, GB, GC, GD, GE, GF. The setpoint of the scanning bed 1 includes T1, T2, T3, T4, T5, T6, TA, TB, TC, TD, TE, TF, TG, TH.
TABLE 1
The processor gives the adjustment scheme according to the parameter deviation values of the plurality of adjustment points provided in table 1, and details are shown in table 2.
TABLE 2
The positions of the scanning bed 1 and the second detector 3 are adjusted according to the adjustment scheme provided in table 2. The scanning bed 1 comprises a plurality of screws for adjusting the scanning bed 1, and the screws are in one-to-one correspondence with a plurality of adjusting points of the scanning bed 1. The second probe 3 includes a plurality of screws for adjusting the second probe 3, the plurality of screws being in one-to-one correspondence with a plurality of adjustment points of the second probe 3. The positions of the scanning bed 1 and the second detector 3 can be adjusted by rotating the screws. In tables 1 and 2, a negative sign indicates that the screw was screwed out, and a positive sign indicates that the screw was screwed in.
After adjusting the scanning bed 1 and the second detector 3, if the scanning bed 1, the second detector 3 and the first detector 2 are not registered, the processor executes steps 101 to 106 again, and re-acquires the first parameter deviation value and the second parameter deviation value, and outputs the translational deviation and the angular deviation of the adjusting point of the second detector 3 between the second scanning view and the first scanning view, and the translational deviation and the angular deviation of the adjusting point of the scanning bed 1 and the first scanning view coordinate system, specifically see table 3.
TABLE 3 Table 3
The processor gives an adjustment scheme according to the parameter deviation values of the plurality of adjustment points provided in table 3, and adjusts the scanning bed 1 and the second detector 3 until the adjustment scheme is shown in table 4, and the translational deviation values and the angular deviation values of the first detector 2, the second detector 3 and the scanning bed 1 are all 0, that is, the first scanning visual field, the second scanning visual field and the scanning bed 1 are completely registered.
TABLE 4 Table 4
For method embodiments, reference is made to the description of device embodiments for the relevant points, since they essentially correspond to the device embodiments. The method embodiments and the device embodiments complement each other.
The foregoing description of the preferred embodiments of the present disclosure is not intended to limit the disclosure, but rather to cover all modifications, equivalents, improvements and alternatives falling within the spirit and principles of the present disclosure.
Claims (11)
1. A coordinate registration phantom for a multi-modality imaging system, the coordinate registration phantom comprising:
a stent, comprising: the device comprises a first supporting rod, a second supporting rod intersected with the first supporting rod, and at least three third supporting rods with the extending direction intersected with the extending direction of the first supporting rod and the extending direction intersected with the second supporting rod, wherein the second supporting rod is connected with the third supporting rods, and at least two third supporting rods are arranged along the second supporting rods in a separated mode; a kind of electronic device with high-pressure air-conditioning system
The mold bodies are separately arranged on the first supporting rods, the mold bodies are arranged on the third supporting rods, and the mold bodies are separately arranged along the extending direction of the third supporting rods; the die body comprises: a body, the body comprising: the cavity is used for containing radioactive substances and is communicated with the cavity, and the through hole is formed in the top wall of the body;
the top wall of the body is provided with a first groove which is concave inwards, and the through hole penetrates through the bottom wall of the first groove.
2. The coordinate registration die body of claim 1, wherein sidewalls of the first groove taper inwardly in a direction toward the cavity.
3. The coordinate registration die body according to claim 1, wherein the bottom wall of the body is provided with a second groove symmetrical to the first groove.
4. The coordinate registration die body of claim 1, wherein the material of the body comprises plexiglas; the radioactive material includes an F18 radioactive material.
5. The coordinate registration die body according to any one of claims 1 to 4, wherein at least two third support rods are provided on both sides of one end of the second support rod, and an end of at least one third support rod is connected to the other end of the second support rod.
6. The coordinate registration die body of claim 5, wherein a middle portion of the first support bar is vertically joined to a middle portion of the second support bar;
and the end parts of at least three third support rods are vertically connected with the second support rods.
7. The coordinate registration die body of claim 5, wherein the die body is provided at both ends of the first support bar, and the die body is provided at ends of at least three of the third support bars facing away from the second support bar.
8. A multi-modality imaging system, the multi-modality imaging system comprising:
a scanning bed;
a first detector comprising a first scan field of view and a second detector comprising a second scan field of view, the scanning bed being movable into the first and second scan fields of view;
the coordinate registration phantom of any of claims 1-7, disposed on the scan bed; a kind of electronic device with high-pressure air-conditioning system
The processor is electrically connected with the first detector and the second detector and is used for: acquiring first space coordinates of the coordinate registration die body in the first scanning view; acquiring second space coordinates of the coordinate registration die body in the second scanning view field; determining a first parameter deviation value between the first scan field of view and the second scan field of view according to the first spatial coordinates and the second spatial coordinates; and adjusting the position of the second detector according to the first parameter deviation value to enable the second scanning visual field to be in registration with the first scanning visual field.
9. The multi-modality imaging system of claim 8, wherein the axis of the first support rod of the coordinate registration phantom forms an angle between the scan bed and the axis of the scan bed, the angle being either acute or right.
10. A method of image registration for a multi-modality imaging system, for use in the multi-modality imaging system of claim 8 or 9, the method comprising:
acquiring first space coordinates of a coordinate registration die body in a first scanning view of a first detector;
acquiring second space coordinates of the coordinate registration die body in a second scanning view of a second detector;
determining a first parameter deviation value between the first scan field of view and the second scan field of view according to the first spatial coordinates and the second spatial coordinates;
and adjusting the position of the second detector according to the first parameter deviation value to enable the second scanning visual field to be in registration with the first scanning visual field.
11. The method according to claim 10, wherein the method further comprises:
determining a second parameter deviation value between the scanning bed and the first scanning field of view according to the first spatial coordinates and the second spatial coordinates;
and adjusting the position of the scanning bed according to the second parameter deviation value to enable the scanning bed to be in registration with the first scanning visual field.
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