CN110280307B - Azabicyclo complex catalyst and preparation method and application thereof - Google Patents

Azabicyclo complex catalyst and preparation method and application thereof Download PDF

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CN110280307B
CN110280307B CN201910357346.XA CN201910357346A CN110280307B CN 110280307 B CN110280307 B CN 110280307B CN 201910357346 A CN201910357346 A CN 201910357346A CN 110280307 B CN110280307 B CN 110280307B
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azabicyclo
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时叶强
曹彤彤
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Inner Mongolia Lingsheng Crop Technology Co ltd
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    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
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Abstract

The invention relates to an azabicyclo tertiary amine complex catalyst and a preparation method thereof, the azabicyclo tertiary amine complex catalyst can be used for preparing 2- [2- [ 6-chloropyrimidine-4-yloxy ] phenyl ] -3, 3-dimethoxy methyl propionate (III) and (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-yloxy ] phenyl ] -3-methoxy methyl acrylate (V), the etherification reaction yield can be obviously improved, and a product with the purity of more than 99.4 percent and white powder in appearance color is prepared.

Description

Azabicyclo complex catalyst and preparation method and application thereof
Technical Field
The invention relates to an azabicyclo tertiary amine complex catalyst and a preparation method thereof, wherein the azabicyclo tertiary amine complex catalyst is a special catalyst which can be applied to synthesis of (2- [2- [ 6-chloropyrimidine-4-yloxy ] phenyl ] -3, 3-dimethoxy methyl propionate (III) and (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-yloxy ] phenyl ] -3-methoxy methyl acrylate (V).
Background
(E) The (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-yloxy ] phenyl ] -3-methoxy methyl acrylate is a high-efficiency broad-spectrum agricultural bactericide, has multiple functions of systemic conduction, prevention, protection, treatment and the like, and has good prevention effects on powdery mildew, rust disease, glume blight, downy mildew, rice blast and the like of plants. The existing industrial synthesis method with economic value is prepared by the reaction of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate and o-hydroxybenzonitrile. The specific synthesis process mainly comprises the following steps:
the earlier patents WO9208703 and EP0382375 used the following process:
Figure BDA0002045829460000011
mixing (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate and o-hydroxybenzonitrile, adding potassium carbonate as an acid-binding agent, taking cuprous chloride as a catalyst and DMF as a solvent, reacting at 120 ℃, and being difficult in post-treatment and crystallization (crystallization at room temperature for 3 weeks) and not suitable for industrial mass production.
WO 0172719A 1 and the related patent CN1280278C disclose a method for preparing unsymmetrical 4, 6-bis (aryloxy) pyrimidine derivatives, which are synthesized by adding 2-40 mol% of 1, 4-diazabicyclo [2,2,2] octane (DABCO) in the presence of a suitable solvent and a suitable base.
Patent CN 101163682B discloses the preparation of methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate using DABCO as a catalyst, reducing the amount of DABCO to 0.1-2 mol%, the yield is still 93.4%.
Patent CN103265496B discloses a process for the preparation of methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate, wherein the catalyst used is azabicyclic tertiary amine compounds and/or salts thereof, and specifically examples of azabicyclic tertiary amine compounds and/or salts thereof are given:
Figure BDA0002045829460000021
wherein, in formula (3), R1And R2Each independently is hydrogen, hydroxy, C1-C6Or C is a hydrocarbon group1-C6Or both are a carbonyl, thiocarbonyl, cycloalkylsulfide, cycloalkoxy or ketal structure; in the formula (4), R3、R4And R5Each independently is hydrogen, C1-C6A hydrocarbon group of1-C6Hydrocarbyloxy, dimethylamino, diethylamino, diisopropylamino, cyano, fluorine, chlorine or bromine; in the formula (5), R6Is hydrogen, C1-C6A hydrocarbon group of1-C6Hydrocarbyloxy, mercapto, dimethylamino, diethylamino, diisopropylamino, cyano, fluoro, chloro or bromo. The azabicyclo tertiary amine compound is as follows: 1-azabicyclo [2, 2] s]Octane, 1-azabicyclo [2, 2] 2]Octane-8-one, 1-azaspiro [1, 3 ]]Dioxolane-2, 3-bicyclo [2, 2]]Octane, 1, 4-diazabicyclo [2, 2] s]Octane, 2-methyl-1, 4-diazabicyclo [2, 2-]Octane, 2, 6-dimethyl-1, 4-diazabicyclo [2,2]Octane, 2, 5-dimethyl-1, 4-diazabicyclo [2,2]Octane, 1, 5-diazabicyclo [3, 2]]Nonane and 6-methyl-1, 5-diazabicyclo [3, 2]At least one of nonanes.
The solvent used in the etherification reaction process is butyl acetate, the reaction temperature is 80-120 ℃, the total dosage of the azabicyclo tertiary amine compound and the salt thereof is 0.05-100mol percent relative to 1mol of (E) -2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxy methyl propionate, and the yield is 92.6-95%.
CN104230822B discloses the synthesis of 4, 6-dichloropyrimidine and methyl 2- (2-hydroxyphenyl) -3, 3-dimethoxypropionate over a catalyst of the structure
Figure BDA0002045829460000022
Wherein R is1、R2、R3Each independently selected from hydrogen and C1-C6Alkyl or alkoxy, dimethylamino, diethylamino, diisopropylamino or halogen, R4Is selected from-COOR6、-COOR7R8，R6、R7、R8Independently selected from H or alkyl of 1-3 carbons, and n is an integer of 0-3. The selected solvent is amide, ether, ester, ketone or aromatic hydrocarbon solvent, such as: DMF, methyl tert-butyl ether, dimethyl sulfoxide, ethyl acetate, toluene, xylene, chlorobenzene nitrobenzene, etc. in 80.2-90.6% yield.
In the prior art, the azabicyclo tertiary amine compound is used as a catalyst for etherification, the conversion rate is about 92-95%, the yield is low, the obtained crude product needs to be recrystallized to obtain a product with higher purity, in addition, the azabicyclo tertiary amine compound has the characteristic of easy sublimation, organic volatile matters are formed, the environment is polluted, the catalyst needs to be supplemented in the later stage of the etherification process, the catalyst is high in price, and the synthesis reaction process is not economical. In view of the above problems, the present invention provides a novel catalyst, a method for synthesizing the same, and an application of the catalyst in the synthesis of compounds (III) and (V).
Disclosure of Invention
The invention provides a novel catalyst azabicyclo complex and a preparation method thereof, which can be used for preparing 2- [2- [ 6-chloropyrimidine-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester (III) and (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-yloxy ] phenyl ] -3-methoxy acrylic acid methyl ester (V), can obviously improve the etherification reaction yield, and prepare a product with the purity of more than 99.4 percent and white powder in appearance color.
In order to achieve the purpose, the invention provides an azabicyclo tertiary amine complex catalyst, the structure of which is shown as formula (I)
Figure BDA0002045829460000031
Wherein R is1、R2、R3、R4Each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amino, or halogen; preferably, the number of carbon atoms of the substituted or unsubstituted alkyl group or the substituted or unsubstituted alkoxy group is C1-C6The substituted or unsubstituted amino groups are independently selected from methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino and diisopropylamino;
x is F, Cl, Br, I or CN;
y is C or N;
n is an integer of 1 to 2.
In another aspect, the present invention provides a method for preparing the azabicyclo tertiary amine complex catalyst, wherein the synthesis step comprises the step of (a) adding cuprous halide or copper cyanide solution dropwise to the nitrile solution of the azabicyclo tertiary amine compound represented by formula (ii), thereby obtaining the compound of formula (i).
Figure BDA0002045829460000032
Wherein R is1、R2、R3、R4Each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amino, or halogen; preferably, the number of carbon atoms of the substituted or unsubstituted alkyl group and the substituted or unsubstituted alkoxy group is C1-C6The substituted or unsubstituted amino groups are independently selected from methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino and diisopropylamino; y is C or N.
In another aspect, the invention relates to the use of said azabicyclo complex catalyst in the synthesis of methyl 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionate (III) and methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate (V), the structural formulas of the methyl 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionate and the methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate are as follows:
Figure BDA0002045829460000041
preferably, the azabicyclo tertiary amine complex catalyst of the invention is selected from complexes comprising the following structural formula:
Figure BDA0002045829460000042
preferably, the preparation method of the azabicyclo tertiary amine complex catalyst further comprises the steps of performing suction filtration in the step (b) and rinsing in the step (c) on the compound of the formula (I) obtained by the reaction.
Preferably, in the method for producing an azabicyclo tertiary amine complex catalyst according to the present invention, the step (a) of adding a cuprous halide or cuprous cyanide solution dropwise to a nitrile solution of the compound represented by formula (ii) is carried out under protection of high-purity nitrogen.
Preferably, in the preparation method of the azabicyclo tertiary amine complex catalyst, the cuprous halide or the cuprous cyanide solution is prepared freshly, and the standing time of the cuprous halide or the cuprous cyanide solution is less than 24 hours, preferably less than 8 hours, and more preferably less than 4 hours.
Preferably, in the method for preparing the azabicyclo tertiary amine complex catalyst, the cuprous halide or cuprous cyanide solution is recrystallized cuprous halide or cuprous cyanide. Preferably, the cuprous halide is cuprous chloride.
Preferably, in the preparation method of the azabicyclo tertiary amine complex catalyst, the leaching in the step (C) is carried out by using non-polar solvent ethers or C6-C7Leaching a filter cake obtained after filtration by using at least one solvent of saturated alkane; preferably, the ether or C6-C7The saturated alkane solvent is one or more of methyl tert-butyl ether, isopropyl ether, n-hexane, cyclohexane, n-heptane and petroleum ether; preferred is petroleum ether.
Preferably, the preparation method of the azabicyclo tertiary amine complex catalyst further comprises the step (d) of drying, preferably vacuum drying; more preferably, the vacuum drying temperature is 30 to 80 ℃, and still more preferably 35 to 50 ℃.
Preferably, in the method for preparing an azabicyclo tertiary amine complex catalyst according to the present invention, the mother liquor obtained by suction filtration is used as a solvent for the compound represented by formula (ii) in step (a).
Preferably, in the method for producing an azabicyclo tertiary amine complex catalyst according to the present invention, the azabicyclo tertiary amine compound (ii) is at least one or more selected from 1-azabicyclo [2,2,2] octane, 1-azabicyclo [2,2,2] octan-8-one, 1, 4-diazabicyclo [2,2,2] octane, 2-methyl-1, 4-diazabicyclo [2,2,2] octane, 2, 6-dimethyl-1, 4-diazabicyclo [2,2,2] octane, and 2, 5-dimethyl-1, 4-diazabicyclo [2,2,2] octane.
Preferably, in the method for preparing the azabicyclo tertiary amine complex catalyst according to the present invention, the nitrile solvent is acetonitrile.
Preferably, in the preparation method of the azabicyclo tertiary amine complex catalyst, the mass concentration of the compound of formula (II) in the nitrile solution is 10-80%, preferably 20-50%.
Preferably, in the preparation method of the azabicyclo tertiary amine complex catalyst, the reaction temperature is 10-50 ℃, and preferably 20-35 ℃.
Preferably, the application of the azabicyclo complex catalyst in the synthesis of 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester is that a compound shown in the formula (IV) and 4, 6-dichloropyrimidine react in the presence of the azabicyclo tertiary amine complex catalyst to prepare a compound shown in the formula (III) and 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester, wherein the structural formula of the compound shown in the formula (IV) is as follows:
Figure BDA0002045829460000061
preferably, in the application of the aza-bicycloheterocycle complex catalyst in the synthesis of 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester, the amount of the aza-bicycloheterocycle complex catalyst is 0.05-40 mol%, preferably 0.1-10 mol%, and more preferably 0.5-2 mol%.
Preferably, the application of the aza-bicyclic complex catalyst in the synthesis of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxy methyl acrylate is that the compound of the formula (VI) and o-hydroxybenzonitrile and/or a salt thereof are subjected to etherification reaction in the presence of the aza-bicyclic tertiary amine complex catalyst to obtain the compound of the formula (V) (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxy methyl acrylate, wherein the structural formula of the formula (VI) is shown as follows:
Figure BDA0002045829460000062
preferably, in the application of the aza-bicycloheterocycle complex catalyst in the synthesis of (E) -methyl 2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate, the amount of the aza-bicycloheterocycle complex catalyst is 0.05-40 mol%, preferably 0.1-10 mol%, and more preferably 0.5-2 mol%.
Preferably, in the application of the aza-bicyclic complex catalyst in the synthesis of (E) -methyl 2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate, the etherification reaction temperature is 50-110 ℃, and preferably 70-80 ℃.
Preferably, in the application of the aza-bicyclic complex catalyst in the synthesis of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxy-acrylic acid methyl ester, the etherification reaction solvent is at least one or a mixture of more than two of DMF, dimethyl sulfoxide, esters, ketones, aromatic hydrocarbons and the like, and is preferably xylene.
Preferably, in the application of the aza-bicycloheterocycle complex catalyst in the synthesis of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxy methyl acrylate, a reaction acid-binding agent is added in the etherification reaction, preferably, the reaction acid-binding agent is at least one of sodium carbonate or potassium carbonate or a mixture of more than two of sodium carbonate or potassium carbonate, and more preferably, the reaction acid-binding agent is potassium carbonate. The present invention provides a catalyst of the structure:
Figure BDA0002045829460000063
wherein R is1、R2、R3、R4Each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amino, or halogen; x is F, Cl, Br, I or CN; y is C or N; n is an integer of 1 to 2.
Preferably, the substituted or unsubstituted alkyl and the substituted or unsubstituted alkoxy are respectively and independently selected from 1-6 carbon atoms.
Preferably, the substituted or unsubstituted amino groups are each independently selected from methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino and diisopropylamino.
Preparation of azabicyclo tertiary amine complex catalyst
The preparation of the azabicyclo tertiary amine complex catalyst of the invention involves the following reaction equation:
Figure BDA0002045829460000071
CAT-1, CAT-2, CAT-3 or a mixture of both CAT-2 and CAT-3 can be prepared by controlling the molar ratio of cuprous halide or cuprous cyanide.
The yield of the azabicyclo complex catalyst prepared by the method is 50-95%, and the yield is different along with different CuX. From the economic aspect, the ligand compound prepared by cuprous halide or cuprous cyanide and DABCO is low in price and high in yield, the yield can reach more than 85%, and furthermore, the yield can reach more than 95% by using the last batch of mother liquor as a reaction solvent, so that the solvent waste and the environmental pollution can be reduced.
Application of azabicyclo tertiary amine complex catalyst in preparation of compound (III)
The invention also provides an application of the prepared azabicyclo complex catalyst in synthesizing a compound (III), which is characterized in that the compound (IV) and 4, 6-dichloropyrimidine react in the presence of at least one azabicyclo complex catalyst with the dosage of 0.05-40 mol% to prepare (III) methyl 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionate.
Figure BDA0002045829460000081
The reaction equation involved is as follows:
Figure BDA0002045829460000082
the aza-bicycloheterocycle complex catalyst prepared by the invention has unexpected catalytic effect on the reaction, can be used for 1-3h under the amount of 0.05-40 mol%, preferably 0.1-10 mol%, more preferably 0.5-2 mol%, the residue of a substrate (IV) can be less than 0.3%, generally about 0.1%, after the reaction is finished, the reaction material is washed by water, and organic phase 2- [2- [ 6-chloropyrimidine-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester is obtained after liquid separation, and the yield is more than 97.0%.
The feeding mode of the reaction is that 3- (methoxy methyl alkenyl) -2(3H) -benzofuranone and azabicyclo complex catalyst are added firstly, sodium methoxide solution is added, then solvent toluene is added, the mixture is stirred and reacted for 0.5H at the temperature of 35-40 ℃, the temperature is reduced to room temperature, compound 4, 6-dichloropyrimidine is added, the mixture is stirred and reacted for 1-5H, the residue of compound (IV) is less than 0.3 percent, and further less than 0.1 percent.
In the application of the aza-bicycloheterocycle complex catalyst in the synthesis of the compound (III), the catalyst is complex salt, is not easy to sublime, does not need to be supplemented with a catalyst in the later period of etherification reaction, and has high catalyst efficiency, so that the reaction is thorough, the reaction conversion rate is high, the catalyst is easy to dissolve in water, and the post-treatment is simple.
Application of azabicyclo tertiary amine complex catalyst in preparation of compound (V)
The invention also provides an application of the prepared azabicyclo complex catalyst in synthesizing a compound (V), which is characterized in that a compound (VI) (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate and o-hydroxybenzonitrile and/or salt thereof react in the presence of at least one azabicyclo complex catalyst with the dosage of 0.05-40 mol% to prepare (V) (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxy methyl acrylate.
Figure BDA0002045829460000083
The reaction equation involved is as follows:
Figure BDA0002045829460000091
the aza-bicycloheterocycle complex catalyst prepared by the invention has unexpected catalytic effect on the etherification reaction, can be used for 2-3h under the amount of 0.05-40 mol%, preferably 0.1-10 mol%, more preferably 0.5-2 mol%, the residue of a substrate (VI) can be less than 0.5%, generally about 0.1%, the reaction material is light red mixture, after crystallization, a white-like to white product is obtained, the yield is more than 96.0%, and the content is more than or equal to 99.4%.
The feeding mode of the etherification reaction is that a solvent is added at normal temperature, ortho-cyanophenol and/or salt thereof is added, potassium carbonate is added, the mixture is stirred for 20-30min to form salt, a compound (VI) is added, finally, an aza-bicycloheterocycle complex catalyst is added, the temperature is gradually increased to 70-80 ℃, the reaction is kept for 2-4h, the residue of the compound (VI) is less than 0.5 percent, and further less than 0.2 percent.
In the application of the aza-bicycloheterocycle complex catalyst in the synthesis of the compound (V), the catalyst is complex salt, is not easy to sublimate, does not need to be supplemented with a catalyst in the later period of etherification reaction, has high catalyst efficiency, so that the reaction is thorough, the product purity is high, recrystallization is not needed, the catalyst is easy to dissolve in water, the post-treatment is simple, the process is simplified, and the problem of incomplete reaction is further solved.
The specific implementation mode is as follows:
for a further understanding of the invention, the following description is given in conjunction with the best mode, but it is to be understood that: these descriptions are further illustrative of the advantages and features of the present invention and are not intended to limit the claims of the present invention.
Examples 1-6 azabicyclo tertiary amine complexesPreparation of the Agents
Examples 1 to 6 prepared the azabicyclo tertiary amine complex catalyst of the present invention by the method of the present application, the yield of the azabicyclo tertiary amine complex was 85% or more, and examples 1 and 3 used the last batch of mother liquor as the reaction solvent, and the yield was 95% or more.
Example 1: preparation of complex of formula I-2 from cuprous bromide and previous mother liquor
(1) Pretreatment of cuprous bromide
Cuprous bromide purchased by industrial production or reagent companies is provided with trace copper bromide, the color is light green, and pretreatment is needed to ensure the catalytic effect.
A four-necked flask was charged with 450g of 3% dilute HBr, and 0.5g of Na was added2SO3Removing the oxidized bromine or oxygen in dilute HBr, reducing the cupric ion to cuprous ion, quickly adding 1000g of reagent-grade CuBr, replacing with high-purity nitrogen gas three times, stirring at normal temperature for about 2 hr, wherein the CuBr is insoluble in dilute HBr and CuBr2Dissolving in dilute HBr, filtering under nitrogen protection, eluting with anhydrous ethanol twice to remove water, vacuum drying at 50-60 deg.C for 2 hr to obtain 930g white crystalline powder with yield of 93.0% and content of 99.7%, placing in a bottle, and introducing nitrogen gas for storage.
(2) Preparation of formula I-2
Figure BDA0002045829460000101
Adding 360g of acetonitrile mother liquor which is filtered in the process of synthesizing the formula I-2, starting stirring, then adding 287.48g of cuprous bromide (99.7%) powder, heating to 45-50 ℃ for dissolution under the protection of nitrogen to obtain light gray solution for later use.
Adding 126.20g of 2-methyl triethylene diamine into a four-mouth bottle, adding 176.54g of acetonitrile mother liquor which is subjected to suction filtration in the process of synthesizing the formula I-2, stirring at normal temperature, introducing nitrogen for protection, dropwise adding the prepared cuprous bromide solution by using a constant-pressure feeding funnel, stirring at 20-30 ℃ for about 20min until light brown ligand compounds are continuously separated out, stirring at normal temperature for 1h after adding, cooling to-10 ℃, crystallizing, performing suction filtration under nitrogen protection to avoid water absorption, repeatedly using 150mL of cyclohexane in the process of synthesizing the formula I-2 for two times for leaching, and then performing vacuum drying at 40-50 ℃ to obtain 403.81g of light brown crystalline powder, wherein the acetonitrile mother liquor is 546.41g, and the yield is 97.75%.
Example 2: preparation of complexes of formula I-2 using cuprous bromide
(1) The copper bromide pretreatment method was the same as in example 1
(2) Preparation of formula I-2
400mL of anhydrous acetonitrile is measured, stirring is started, 287.48g of cuprous bromide (99.7%) powder is added, nitrogen is protected, and the mixture is heated to 45-50 ℃ to be dissolved and clear to be light gray solution for later use.
Adding 126.20g of 2-methyl triethylene diamine into a four-mouth bottle, adding 200mL of acetonitrile, dissolving at normal temperature, introducing nitrogen for protection, dropwise adding the prepared cuprous bromide solution by using a constant-pressure addition funnel, keeping the temperature at 20-30 ℃, completing the addition for about 20min, continuously separating out light brown ligand compounds, stirring at normal temperature for 1h after completing the addition, then cooling to-10 ℃, crystallizing, performing suction filtration under the protection of nitrogen to avoid water absorption, then leaching twice by using 150mL of cyclohexane, and then performing vacuum drying at 40-50 ℃ to obtain 351.14g of light brown crystalline powder, wherein the acetonitrile mother liquor has 536.54g and the yield is 85%.
Example 3: preparation of the Complex of formula I-22 Using cuprous chloride and the last batch of mother liquor
(1) Pretreatment of cuprous chloride
Cuprous chloride purchased by industrial production or reagent companies is provided with trace copper chloride, the color is light green, and pretreatment is needed to ensure the catalytic effect.
A four-necked flask was charged with 450g of 3% dilute HCl and 0.5g of Na2SO3Removing the oxidized chlorine or oxygen in dilute hydrochloric acid, simultaneously reducing the cupric ions into cuprous ions, quickly adding 500g of reagent-grade CuCl, replacing with high-purity nitrogen for three times, stirring at normal temperature for about 2hSince CuCl is insoluble in dilute hydrochloric acid, CuCl2Dissolving in dilute hydrochloric acid, filtering under the protection of nitrogen to achieve the purpose of separation and purification, rinsing twice with absolute ethyl alcohol to remove water, vacuum drying at 50-60 ℃ for 2h to obtain 460g of white crystalline powder with the yield of 92.0% and the content of 99.8%, placing in a bottle, and flushing nitrogen to store for later use.
(2) Preparation of formula I-22
Figure BDA0002045829460000111
Weighing 172g of acetonitrile mother liquor which is filtered in the process of synthesizing the formula I-2, starting stirring, adding 99.20g of cuprous chloride powder, protecting with nitrogen, heating to 45-50 ℃ to dissolve to obtain light gray solution for later use.
Adding 63.10g of 2-methyl triethylene diamine into a four-mouth bottle, adding 86.09g of acetonitrile mother liquor which is obtained by suction filtration in the process of synthesizing the formula I-22, stirring at normal temperature, introducing nitrogen for protection, dropwise adding the prepared cuprous chloride solution by using a constant-pressure addition funnel, stirring at 20-30 ℃ for about 20min until a reddish brown di-ligand compound is continuously separated out, stirring at normal temperature for 1h after adding, cooling to-10 ℃, crystallizing, suction filtration under nitrogen protection to avoid water absorption, then leaching twice by using 75mL of normal hexane, and then drying in vacuum at 40-50 ℃ to obtain 159.36g of reddish brown crystal powder, wherein the acetonitrile mother liquor is 261.03g, and the yield is 98.31%.
Example 4: preparation of the Complex of formula I-22 Using cuprous chloride
(1) The copper chloride pretreatment method was the same as in example 3
(2) Preparation of the Complex of formula I-22
200mL of anhydrous acetonitrile is measured, stirring is started, 99.20g of cuprous chloride powder is added, nitrogen protection is carried out, and the mixture is heated to 45-50 ℃ to be dissolved to obtain a light gray solution for later use.
Adding 63.10g of 2-methyl triethylene diamine into a four-mouth bottle, adding 100mL of acetonitrile, dissolving at normal temperature, introducing nitrogen for protection, dropwise adding the prepared cuprous chloride solution by using a constant-pressure addition funnel, keeping the temperature at 20-30 ℃, completing the addition for about 20min, continuously separating out a reddish-brown di-ligand compound, stirring at normal temperature for 1h after completing the addition, then cooling to-10 ℃, crystallizing, performing suction filtration under the protection of nitrogen to avoid water absorption, then leaching twice by using 75mL of n-hexane, and then performing vacuum drying at 40-50 ℃ to obtain 141.03g of reddish-brown crystalline powder, wherein the acetonitrile mother liquor has 258.27g, and the yield is 87%.
Example 5: preparation of the Complex of formula I-23 Using cuprous chloride
(1) The copper chloride pretreatment method was the same as in example 3
(2) Preparation of formula I-23
Figure BDA0002045829460000121
400mL of anhydrous acetonitrile is measured, stirring is started, 99.20g of cuprous chloride powder is added, nitrogen protection is carried out, and the mixture is heated to 45-50 ℃ to be dissolved clearly to be light gray solution for later use.
77.10g of 2-methyl-6-ethyl-1, 4-diazabicyclo [2,2,2] octane is added into a four-mouth bottle, 50mL of acetonitrile is added, the mixture is uniformly mixed at normal temperature, nitrogen protection is filled, a constant-pressure feeding funnel is used for dropwise adding the prepared cuprous chloride solution, the temperature is 20-30 ℃, the addition is finished for about 20min, the diligand compound of the reddish-brown 2-methyl-6-ethyl-1, 4-diazabicyclo [2,2,2] octane is continuously separated out, the mixture is stirred at normal temperature for 1h after the addition is finished, then the temperature is reduced to-10 ℃, crystallization is carried out, suction filtration is carried out under the protection of nitrogen, water absorption is avoided, then 150mL of n-hexane is used for carrying out drip washing twice, and then vacuum drying is carried out at 40-50 ℃, 165.4g of reddish-brown crystalline powder is obtained, and the yield is 93.8%.
Example 6: preparation of complexes of formula I-13 using cuprous cyanide
(1) Pretreatment of cuprous cyanide
Cuprous cyanide purchased by industrial production or reagent companies is provided with trace copper cyanide, the color is light green, and pretreatment is needed to ensure the catalytic effect.
450g of deionized water was added to a four-necked flask, and 0.5g of Na2SO was added3In the waterRemoving the oxidation state oxygen, simultaneously reducing the divalent copper ions into cuprous ions, quickly adding 500g of industrial-grade CuCN, replacing three times with high-purity nitrogen, stirring for about 2 hours at normal temperature, filtering under the protection of nitrogen, leaching with absolute ethyl alcohol twice to remove water, and drying in vacuum at 50-60 ℃ for 2 hours to obtain 479g of white crystalline powder, wherein the yield is 95.8%, the content is 99.3%, putting the white crystalline powder into a bottle, and flushing nitrogen for storage for later use.
(2) Preparation of formula I-13
Figure BDA0002045829460000122
200mL of anhydrous acetonitrile is measured, stirring is started, 179.12g of cuprous cyanide powder is added, nitrogen protection is carried out, and the mixture is heated to 45-50 ℃ to be clear and colorless solution for later use.
Adding 140.30g of 2, 3-methyl triethylene diamine into a four-mouth bottle, adding 100mL of anhydrous acetonitrile, stirring at normal temperature, introducing nitrogen for protection, dropwise adding the prepared cuprous cyanide solution by using a constant-pressure addition funnel at the temperature of 20-30 ℃ for about 20min, continuously separating out a light brown di-ligand compound, stirring at normal temperature for 1h after adding, cooling to-10 ℃, crystallizing, performing suction filtration under the protection of nitrogen to avoid water absorption, leaching twice by using 150mL of n-hexane, and performing vacuum drying at 40-50 ℃ to obtain 294.12g of light brown crystalline powder, wherein the yield is 92.10%.
Examples 7-9 application of azabicyclo tertiary amine complex catalysts to preparation of Compound (III)
Examples 7 to 9 azabicyclo tertiary amine complex catalysts prepared in examples 1 to 6 were used to synthesize compound (III). The conversion rate of the product reaches more than 97 percent.
Figure BDA0002045829460000131
EXAMPLE 7 Synthesis of Compound (III) catalyzed by the Complex of formula I-2 with the catalyst of example 1
In a dry four-necked flask, 0.5mol of 89.8g of 3- (methoxymethyl alkenyl) -2(3H) -benzofuranone is added, then 0.21g (0.05 mol%) of the catalyst of formula I-2 is added, then 91.8g of sodium methoxide solution (content: 30.0%) and 500g of anhydrous toluene are added, the mixture is stirred and reacted at 35-40 ℃ for 0.5H, then the temperature is reduced to 25 ℃ and 0.5mol of technical grade 4, 6-dichloropyrimidine is added, the mixture is stirred and reacted for 1H, the HPLC external standard method is used for measuring that (3- (methoxymethyl alkenyl) -2(3H) -benzofuranone is less than 0.30%, 300mL of water is added, the phases are separated, the oil phase weight is 698g, the content of 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester is 24.51%, the conversion rate is 97.20%, the reaction solution is not post-treated, directly used for subsequent configuration transposition reaction.
EXAMPLE 8 Synthesis of Compound (III) catalyzed by the Complex of formula I-22 with the catalyst of example 3
In a dry four-necked flask, 0.5mol of 89.8g of 3- (methoxymethyl alkenyl) -2(3H) -benzofuranone, 1.62g (0.5 mol%) of the catalyst of the formula I-22, 91.8g of sodium methoxide solution (content: 30.0%), 500g of anhydrous toluene were added, the mixture was stirred at 35 to 40 ℃ for 0.5 hour, then cooled to room temperature of 25 ℃, 0.5mol of technical grade 4, 6-dichloropyrimidine was added at 75.25g, the mixture was stirred for 1 hour, HPLC external standard method (content: 0.20% of 3- (methoxymethyl alkenyl) -2(3H) -benzofuranone, 300mL of water was added, the phases were separated, oil phase weight was 699g, 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester content was 24.61%, conversion was 97.74%, the reaction solution was not post-treated, directly used for subsequent configuration transposition reaction.
EXAMPLE 9 Synthesis of Compound (III) catalyzed by the Complex of formula I-13 with the catalyst of example 6
In a dry four-necked flask, 0.5mol of 3- (methoxymethylenyl) -2(3H) -benzofuranone 89.8g, 6.39g (2.0 mol%) of the catalyst of the formula I-13, 91.8g of sodium methoxide solution (content: 30.0%), 500g of anhydrous toluene are added, the mixture is stirred at 35-40 ℃ for 0.5H, then cooled to room temperature of 25 ℃, 0.5mol of technical grade 4, 6-dichloropyrimidine 75.25g is added, the mixture is stirred for 1H, the content of (3- (methoxymethylenyl) -2(3H) -benzofuranone measured by HPLC external standard method is less than 0.15%, 300mL of water is added, the phases are separated, the oil phase weighs 704g, the content of methyl 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionate is 24.33%, the conversion rate is 97.32%, the reaction solution is not subjected to post-treatment, directly used for subsequent configuration transposition reaction.
Example 10-15 application of azabicyclo tertiary amine complex catalyst to preparation of Compound (V)
Examples 10-15 azabicyclo tertiary amine complex catalysts prepared in examples 1-6 were used to synthesize compound (V). The purity of the product reaches more than 99.4 percent, and the yield reaches more than 96.0 percent.
Figure BDA0002045829460000141
EXAMPLE 10 Synthesis of Compound (V) catalyzed by the Complex of formula I-2 Using the catalyst of example 1
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-neck flask, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 0.21g (0.05 mol%) of a catalyst of formula I-2, gradually heating to 80 ℃, carrying out heat preservation reaction for 4 hours, obtaining a light red suspension, measuring the residue of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate to be 0.23% by an HPLC external standard method, cooling, adding 300mL of water, carrying out phase separation, carrying out light yellow green in water phase, washing with water, standing for layering, measuring the weight of an oil phase to be 630.1g, and measuring the content of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] by the external standard method The methyl-3-methoxyacrylate contains 31.02 percent, the conversion rate is 96.91 percent, xylene is removed in vacuum, then 120mL of methanol is added, stirring is carried out for dissolution, 600mL of n-hexane is added dropwise, 0.1g of seed crystal is added, crystallization and suction filtration are carried out, 100mL of n-hexane is used for leaching, vacuum drying is carried out for 2 hours, and white crystalline powder with the purity of 99.5 percent, the weight of 196.44g and the yield of 96.4 percent is obtained.
EXAMPLE 11 Synthesis of Compound (V) Using the catalyst of formula I-22 of example 3
Adding 593.5g of a xylene solution containing 0.5mol of (E) -methyl 2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxyacrylate into a dry four-mouth bottle, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 129.68g (40 mol%) of a catalyst of the formula I-22, gradually heating to 75 ℃, carrying out heat preservation reaction for 4h to obtain a light red suspension, measuring the residue of the methyl (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxyacrylate by an HPLC external standard method to be 0.12%, cooling to 300mL of water, measuring the material to be light red, measuring the water phase to be light yellow green, carrying out phase separation, washing with water, standing for layering, measuring the oil phase to be 630.5g, and measuring the content of the (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-organic silicon by the external standard method The content of the methoxy group ] phenyl ] -3-methoxy methyl acrylate is 31.43 percent, the conversion rate is 98.3 percent, xylene is removed in vacuum, then 120mL of methanol is added, stirring is carried out to dissolve the xylene, 600mL of normal hexane is dripped, 0.1g of seed crystal is added, crystallization and suction filtration are carried out, 100mL of normal hexane is used for leaching, and vacuum drying is carried out for 2 hours, so that white crystalline powder with the purity of 99.5 percent, the weight of 199.2g and the yield of 97.8 percent is obtained.
EXAMPLE 12 Synthesis of Compound (V) Using the catalyst of formula I-23 of example 5
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-neck flask, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 1.76g (0.5 mol%) of a catalyst of the formula I-23, gradually heating to 75 ℃, carrying out heat preservation reaction for 4 hours to obtain a light red suspended liquid, measuring the residue of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate by an HPLC external standard method to be 0.07%, reducing the temperature, 300mL of water, weighing 628.6g of an oil phase, and measuring the content of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-methoxy methyl acrylate by an external standard method 31.54 percent of-acyloxy ] phenyl ] -3-methoxy methyl acrylate, 98.3 percent of conversion rate, removing xylene in vacuum, adding 120mL of methanol, stirring for dissolving, dropwise adding 600mL of n-hexane, adding 0.1g of seed crystal, crystallizing, performing suction filtration, leaching by using 100mL of n-hexane, and performing vacuum drying for 2 hours to obtain white crystalline powder with the purity of 99.6 percent, the weight of 199.06g and the yield of 97.9 percent.
EXAMPLE 13 Synthesis of Compound (V) Using the catalyst of formula I-22 of example 3
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-neck flask, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 6.48g (2 mol%) of a catalyst of formula I-22, gradually heating to 70 ℃, carrying out heat preservation reaction for 4 hours to obtain a light red suspension, measuring the residue of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate by an HPLC external standard method to be 0.15%, reducing the temperature, 300mL of water, measuring the material to be light red, measuring the water phase to be light yellow green, carrying out phase separation, washing with water, standing for layering, weighing 633.6g of an oil phase, and measuring the content of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-methoxy methyl acrylate by the external standard method 31.42 percent of-acyloxy ] phenyl ] -3-methoxy methyl acrylate, 98.7 percent of conversion rate, removing xylene in vacuum, adding 120mL of methanol, stirring for dissolving, dropwise adding 600mL of n-hexane, adding 0.1g of seed crystal, crystallizing, performing suction filtration, leaching by using 100mL of n-hexane, and performing vacuum drying for 2 hours to obtain white crystalline powder with the purity of 99.6 percent, the weight of 199.88g and the yield of 98.3 percent.
EXAMPLE 14 Synthesis of Compound (V) Using the catalyst of formula I-13 of example 6
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-neck flask, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 0.32g (0.1 mol%) of a catalyst shown in the formula I-13, gradually heating to 80 ℃, carrying out heat preservation reaction for 4 hours to obtain a light red suspended liquid, measuring the residue of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate by an HPLC external standard method to be 0.15%, reducing the temperature, 300mL of water, obtaining a material which is light red and light green in water phase, carrying out phase separation, washing with water, standing for layering, weighing 629.5g of an oil phase, and measuring the content of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-methoxy methyl acrylate by an external standard method 31.23% of methyl-phenoxy ] phenyl ] -3-methoxyacrylate, 97.47% of conversion rate, removing xylene in vacuum, adding 120mL of methanol, stirring for dissolving, dropwise adding 600mL of n-hexane, adding 0.1g of seed crystal, crystallizing, performing suction filtration, leaching with 100mL of n-hexane, and performing vacuum drying for 2 hours to obtain white crystalline powder with the purity of 99.4%, the weight of 197.8g and the yield of 96.7%.
EXAMPLE 15 Synthesis of Compound (V) Using the catalyst of formula I-22 of example 3
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-neck flask, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 32.4g (10 mol%) of a catalyst of formula I-22, gradually heating to 75 ℃, carrying out heat preservation reaction for 4 hours to obtain a light red suspension, measuring the residue of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate by an HPLC external standard method to be 0.15%, reducing the temperature, 300mL of water, measuring the material to be light red, measuring the water phase to be light yellow green, carrying out phase separation, washing with water, standing for layering, weighing 630.2g of an oil phase, and measuring the content of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-methoxy methyl acrylate by an external standard method 31.43 percent of-acyloxy ] phenyl ] -3-methoxy methyl acrylate, 98.2 percent of conversion rate, removing xylene in vacuum, adding 120mL of methanol, stirring for dissolving, dropwise adding 600mL of n-hexane, adding 0.1g of seed crystal, crystallizing, performing suction filtration, leaching by using 100mL of n-hexane, and performing vacuum drying for 2 hours to obtain white crystalline powder with the purity of 99.6 percent, the weight of 198.9g and the yield of 97.8 percent.
Comparative examples 1-5 comparative tests using prior art catalysts
Comparative examples 1-5 compound (v) was synthesized using catalysts of the prior art, which had relatively lower catalyst purity and yield than the catalytic effect of the azabicyclo tertiary amine complex catalysts of the present application. Therefore, the azabicyclo tertiary amine complex catalyst can obtain higher purity and yield when a compound (V) is catalytically synthesized, wherein the purity is over 99.4%, and the yield is over 96%.
Comparative example 1 the same conditions as in example 10 were used except that the catalyst used was a compound of the following structure (formula II-1)
Figure BDA0002045829460000161
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-neck flask, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 0.063g (0.05 mol%) of the catalyst shown in the formula II-1, gradually heating to 75 ℃, carrying out heat preservation reaction for 4h, measuring the residue of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate by an HPLC external standard method to be 3.8%, reducing the temperature, 300mL of water, obtaining a material which is reddish brown, the water phase is orange yellow, carrying out phase separation, washing with water, standing for layering, weighing 620.2g of the oil phase, and measuring the content of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy) methyl acrylate by the external standard method The content of methyl phenyl-3-methoxyacrylate is 30.66%, the conversion rate is 94.28%, xylene is removed in vacuum, then 120mL of methanol is added, stirring is carried out for dissolution, 600mL of n-hexane is added dropwise, 0.1g of seed crystal is added, crystallization and suction filtration are carried out, 100mL of n-hexane is used for leaching, and vacuum drying is carried out for 2h, so that white crystalline powder with the purity of 98.6%, the weight of 192.9g and the yield of 93.0% is obtained.
Comparative example 2 the same conditions as in example 12 were used except that the catalyst used was a compound of the following structure (formula II-2)
Figure BDA0002045829460000171
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-necked bottle, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 0.77g (0.5 mol%) of a catalyst of the formula II-2, gradually heating to 75 ℃, carrying out heat preservation reaction for 4 hours to obtain a material which is a reddish brown suspension, measuring the residue of the (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate by an HPLC external standard method to be 0.48%, reducing the temperature, 300mL of water, obtaining the material which is reddish brown, orange and yellow in an aqueous phase, carrying out phase separation, washing with water, standing for layering, weighing 612.5g of an oil phase, and measuring the content of the (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-methoxy methyl acrylate by the external standard method The content of the methoxy group ] phenyl ] -3-methoxy methyl acrylate is 31.13 percent, the conversion rate is 94.53 percent, xylene is removed in vacuum, then 120mL of methanol is added, stirring is carried out for dissolution, 600mL of n-hexane is added dropwise, 0.1g of seed crystal is added, crystallization and suction filtration are carried out, 100mL of n-hexane is used for leaching, vacuum drying is carried out for 2 hours, the white crystalline powder is obtained, the purity is 97.6 percent, the weight is 195.4g, and the yield is 92.3 percent.
Comparative example 3 the same conditions as in example 13 were used except that the catalyst used was a compound of the following structure (formula II-3)
Figure BDA0002045829460000172
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-necked bottle, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 2.52g (2 mol%) of a catalyst shown in the formula II-3, gradually heating to 75 ℃, carrying out heat preservation reaction for 4 hours to obtain a material which is a reddish brown suspension, measuring the residue of the (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate by an HPLC external standard method to be 0.15%, reducing the temperature, 300mL of water, measuring the material to be reddish brown, separating the water phase from yellow, washing with water, standing for layering, weighing 620.3g of an oil phase, and measuring the content of the (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-methoxy methyl acrylate by the external standard method The content of the methoxy group ] phenyl ] -3-methoxy methyl acrylate is 30.12 percent, the conversion rate is 92.6 percent, xylene is removed in vacuum, then 120mL of methanol is added, stirring is carried out for dissolution, 600mL of n-hexane is added dropwise, 0.1g of seed crystal is added, crystallization and suction filtration are carried out, 100mL of n-hexane is used for leaching, vacuum drying is carried out for 2 hours, the obtained product is white crystalline powder, the purity is 97.0 percent, the weight is 192.6g, and the yield is 89.85 percent.
Comparative example 4 the same conditions as in example 14 were used except that the catalyst used was a compound of the following structure (formula II-4)
Figure BDA0002045829460000181
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-necked bottle, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 0.14g (0.1 mol%) of a catalyst of the formula II-4, gradually heating to 80 ℃, carrying out heat preservation reaction for 4 hours to obtain a material which is a reddish brown suspension, measuring the residue of the (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate by an HPLC external standard method to be 4.5%, reducing the temperature, 300mL of water, obtaining the material which is reddish brown, orange and yellow in an aqueous phase, carrying out phase separation by washing, standing and layering, weighing 626.9g of an oil phase, and measuring the content of the (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-methoxy methyl acrylate by the external standard method 30.01 percent of methoxy group ] phenyl ] -3-methoxy methyl acrylate, 93.28 percent of conversion rate, removing xylene in vacuum, then adding 120mL of methanol, stirring for dissolving, dropwise adding 600mL of normal hexane, adding 0.1g of seed crystal, crystallizing, filtering, leaching with 100mL of normal hexane, drying in vacuum for 2 hours to obtain white crystalline powder with the purity of 97.2 percent, the weight of 193.6g and the yield of 90.7 percent.
Comparative example 5 the same conditions as in example 15 were used except that the catalyst used was a compound of the following structure (formula II-5)
Figure BDA0002045829460000182
Adding 593.5g of a xylene solution containing 0.5mol of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate into a dry four-necked bottle, adding 79.3g of potassium carbonate and 65.5g of o-hydroxybenzonitrile, then adding 14.02g (10 mol%) of a catalyst shown in the formula II-5, gradually heating to 70 ℃, carrying out heat preservation reaction for 4 hours to obtain a material which is a reddish brown suspension, measuring the residue of (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl ] -3-methoxy methyl acrylate to be 4.5% by an HPLC external standard method, cooling, adding 300mL of water to obtain a material which is reddish brown, orange yellow in an aqueous phase, carrying out phase separation by water washing, carrying out standing for layering, weighing 615.8g of an oil phase, and measuring the content of (E) -2- [2- [6- (2-cyanophenoxy) pyrimidine-4-methoxy methyl acrylate by an external standard method 30.06% of methyl-phenoxy ] phenyl ] -3-methoxyacrylate, 91.78% of conversion rate, removing xylene in vacuum, adding 120mL of methanol, stirring for dissolving, dropwise adding 600mL of n-hexane, adding 0.1g of seed crystal, crystallizing, performing suction filtration, leaching with 100mL of n-hexane, and performing vacuum drying for 2 hours to obtain white crystalline powder with the purity of 96.9%, the weight of 191.0g and the yield of 88.93%.
The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited to the above embodiments, and the specific details are within the technical scope of the present invention even if the respective catalysts of the present invention are combined, which falls within the protective scope of the present invention.

Claims (18)

1. An azabicyclo tertiary amine complex catalyst is characterized in that the structure is shown as formula (I)
Figure FDA0003584728970000011
Wherein R is1、R2、R3、R4Each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amino, or halogen;
x is selected from F, Cl, Br, I or CN;
y is selected from C or N;
n is an integer of 1 to 2.
2. The azabicyclo tertiary amine complex catalyst of claim 1, wherein R is1、R2、R3、R4Is independently selected from C1-C6Substituted or unsubstituted alkyl of, C1-C6Substituted or unsubstituted alkoxy group of (a).
3. The azabicyclic tertiary amine complex catalyst of claim 2, wherein R is1、R2、R3、R4Is independently selected from methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino and diisopropylamino.
4. The azabicyclo tertiary amine complex catalyst of any one of claims 1-3, selected from the group consisting of complexes comprising the following structural formula:
Figure FDA0003584728970000012
Figure FDA0003584728970000021
5. a preparation method of an azabicyclo tertiary amine complex catalyst is characterized in that the synthesis step comprises the steps of (a) dropwise adding cuprous halide or cuprous cyanide solution into nitrile solution containing an azabicyclo tertiary amine compound shown in a formula (II); the reaction thus gives a complex of formula (I) as defined in any one of claims 1 to 4:
Figure FDA0003584728970000022
wherein R is1、R2、R3、R4Each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amino, or halogen; y is C or N;
the nitrile solution is acetonitrile;
the number of carbon atoms of the substituted or unsubstituted alkyl group and the substituted or unsubstituted alkoxy group is 1 to 6;
the substituted or unsubstituted amino group is selected from methylamino, ethylamino, propylamino, isopropylamino, dimethylamino, diethylamino, dipropylamino and diisopropylamino.
6. The process of claim 5, further comprising the steps of (b) suction filtration and (c) rinsing the reacted complex of formula (I).
7. The method for preparing an azabicyclo tertiary amine complex catalyst as claimed in claim 6 wherein step (a) is carried out under a high purity nitrogen atmosphere by adding cuprous halide or cuprous cyanide solution dropwise to the nitrile solution containing the compound of formula (II).
8. The process of claim 6, wherein the cuprous halide or cuprous cyanide solution is recrystallized cuprous halide or cuprous cyanide; the cuprous halide is cuprous chloride.
9. The process for preparing azabicyclo tertiary amine complex catalysts according to any one of claims 6-8, wherein step (C) comprises rinsing with a non-polar solvent such as ethers or C6-C7And leaching the filter cake obtained after filtration by using at least one solvent in saturated alkane.
10. The process for preparing an azabicyclo tertiary amine complex catalyst as claimed in any one of claims 6 to 8 further comprising the steps of (d) drying; the drying step is vacuum drying.
11. The process for producing an azabicyclic tertiary amine complex catalyst according to any one of claims 6 to 8, wherein the mother liquor obtained by suction filtration is used as a solvent for the compound represented by the formula (II) in the step (a).
12. The method for producing an azabicyclo tertiary amine complex catalyst according to any one of claims 6 to 8, wherein the azabicyclo tertiary amine compound (II) is at least one or more selected from the group consisting of 1-azabicyclo [2,2,2] octane, 1-azabicyclo [2,2,2] octane-8-one, 1, 4-diazabicyclo [2,2,2] octane, 2-methyl-1, 4-diazabicyclo [2,2,2] octane, 2, 6-dimethyl-1, 4-diazabicyclo [2,2,2] octane, and 2, 5-dimethyl-1, 4-diazabicyclo [2,2,2] octane.
13. The application of the azabicyclo tertiary amine complex catalyst in synthesizing 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester is characterized in that the azabicyclo tertiary amine complex catalyst of any one of claims 1 to 4 is used, and the structural formula of the 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester is shown as a formula (III)
Figure FDA0003584728970000031
14. The application of the azabicyclo tertiary amine complex catalyst in the synthesis of methyl 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionate according to claim 13, which is characterized in that 4, 6-dichloropyrimidine and a compound shown in a structural formula (IV) are used as raw materials,
Figure FDA0003584728970000032
in the presence of the azabicyclo tertiary amine complex catalyst, reacting to obtain 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionic acid methyl ester.
15. Use of azabicyclo tertiary amine complex catalysts according to claim 13 or 14 for the synthesis of methyl 2- [2- [ 6-chloropyrimidin-4-yloxy ] phenyl ] -3, 3-dimethoxypropionate in the amount of 0.05 to 40 mol%.
16. Use of an azabicyclo tertiary amine complex catalyst in the synthesis of methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate, wherein the methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate has the formula (V):
Figure FDA0003584728970000041
17. the use of azabicyclo tertiary amine complex catalysts according to claim 16 for the synthesis of methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate, wherein a compound of formula (vi) is etherified with o-hydroxybenzonitrile and/or a salt thereof in the presence of the azabicyclo tertiary amine complex catalyst to produce methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxyacrylate of formula (v), wherein formula (vi) is as follows:
Figure FDA0003584728970000042
18. the use of the azabicyclic tertiary amine complex catalyst according to claim 16 or 17 in the synthesis of methyl (E) -2- [2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy ] phenyl ] -3-methoxypropenoate in an amount of 0.05-40 mol%.
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