CN110280194B - Non-contact liquid ultrasonic suspension reaction device and liquid non-contact reaction method - Google Patents
Non-contact liquid ultrasonic suspension reaction device and liquid non-contact reaction method Download PDFInfo
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Abstract
The invention provides a non-contact liquid ultrasonic suspension reaction device and a liquid non-contact reaction method, which belong to the technical field of liquid non-contact ultrasonic suspension reaction, and particularly comprise a reactor packaged with inert gas, wherein at least 1 ultrasonic standing wave suspension unit, an ultrasonic reflection unit, a sample injection unit, an adjusting bracket and a sample adjusting bracket are arranged in the reactor; the method is characterized in that under the condition of inert gas, the sample injection unit works to inject reaction liquid to the standing wave suspension point of the ultrasonic standing wave suspension unit, so that various reaction liquids are mixed on the standing wave suspension point, the reaction speed is accelerated under the action of a sound field, and the non-contact reaction is realized. The invention can avoid the problem that the common chemical reaction causes larger error to the reaction structure due to the cleaning of the container wall and the mechanical influence, and the reaction result, the reaction time and the reaction rate can be accurately controlled, thereby having no pollution, little investment, low cost, safety, cleanness and environmental protection.
Description
Technical Field
The invention belongs to the technical field of liquid non-contact ultrasonic suspension reaction, and particularly relates to a non-contact liquid ultrasonic suspension reaction device and a liquid non-contact reaction method.
Background
With the rapid development of electronic technology, condensed state physics, chemical material analysis and biotechnology, in the experimental process of fields such as precision finishing, agriculture, chemical industry, biomedical engineering, etc., the sample brings uncertain adsorption, memory effect, sample loss, sample pollution and other research errors to cause adverse effects on the result because of contact with the container wall.
The ultrasonic suspension technology is a container-free processing technology for suspending an object at an ultrasonic standing wave field sound pressure junction by using sound radiation force, can process a sample with the volume of a few microliters or even dozens of picoliters in a non-contact mode, avoids errors or adverse effects caused by contact of container walls, and eliminates interference on reaction and optical interference caused by interaction between the container walls and the sample.
However, the current ultrasonic and chemical structures still remain in the technical aspects of ultrasonic cavitation, ultrasonic degradation, ultrasonic stirring, ultrasonic decomposition and the like, and the technology for realizing different medicament reactions by utilizing ultrasonic suspension is not discovered.
Disclosure of Invention
In order to overcome the problems and technical requirements of the ultrasonic chemical reaction technology in the prior art, the invention provides a non-contact liquid ultrasonic suspension reaction device, which couples a stepped amplitude transformer structure and a spring-like constant-section amplitude transformer structure to superpose an exponential type vibration mode and a spiral spring-like longitudinal vibration mode, realizes accurate control of liquid drops under the condition of low power, and is environment-friendly and low in pollution.
Meanwhile, the invention also provides a liquid non-contact reaction method realized by utilizing the non-contact liquid ultrasonic suspension reaction device.
The technical scheme adopted by the invention is as follows:
a non-contact liquid ultrasonic suspension reaction device comprises a reactor packaged with inert gas, wherein at least 1 ultrasonic standing wave suspension unit, an ultrasonic reflection unit, a sample injection unit, an adjusting bracket and a sample adjusting bracket are arranged in the reactor; the ultrasonic standing wave suspension unit is arranged on the adjusting bracket, the position of a standing wave suspension point between the ultrasonic standing wave suspension unit and the ultrasonic reflection unit is adjusted through the adjusting bracket, and the ultrasonic transmitting ends of the ultrasonic standing wave suspension unit and the ultrasonic reflection unit are in one-to-one correspondence and are arranged oppositely; the sample injection unit is arranged on the sample adjusting frame, and the position and the angle of the sample injection unit are adjusted through the sample adjusting frame, so that the injection port of the sample injection unit is opposite to the standing wave suspension point of the ultrasonic standing wave suspension unit.
Further, the ultrasonic standing wave suspension units are multiple, and standing wave suspension points of the multiple ultrasonic standing wave suspension units are distributed on the same straight line at equal intervals or at non-equal intervals, so that an ultrasonic mixed field is formed.
Further inject, ultrasonic standing wave suspension unit is including the piezoceramics heap, vibration output pole and the variable cross section amplitude transformer that set gradually, the variable cross section amplitude transformer includes 2 grades at least sub amplitude transformers, and the diameter that one-level sub amplitude transformer is less than or equal to adjacent last level from the diameter of amplitude transformer, makes to connect into ladder type amplitude transformer structure between the sub amplitude transformer, and the transmitting terminal cross-section of last level sub amplitude transformer is the spherical crown shape, and the directive property is better when making the longitudinal vibration enlargies.
Further limiting, the vibration output rod comprises at least 1 spring-like pipe which is formed by equal-section straight pipes provided with a plurality of spiral through grooves on the side wall; the starting points of the spiral through grooves are uniformly distributed on the same circumferential line, and the strain and the stress of the piezoelectric ceramic stack are superposed by utilizing the spring-like pipe structure, so that the output longitudinal further amplitude is amplified.
Further limiting, the central angle of the spherical crown-shaped transmitting end of the last-stage sub amplitude transformer is 120-150 degrees; the height h does not exceed 1/3 corresponding to the sub-horn diameter.
Further defined, the sample injection unit comprises at least 2 reaction liquid injectors, and the distance between each reaction liquid injector and the standing wave suspension point of the ultrasonic standing wave suspension unit is not less than 2 mm.
Further, the distance between the standing wave suspension points of the ultrasonic standing wave suspension unit is 0.95-2.85 cm, and each standing wave suspension point is on an integral multiple node of half wavelength.
A liquid non-contact reaction method realized by the non-contact liquid ultrasonic suspension reaction device comprises the following steps:
adjusting the adjusting support to ensure that the transmitting end of the ultrasonic standing wave suspension unit is just opposite to the ultrasonic reflection unit, then adjusting the position and the inclination angle of the sample injection unit by using the sample adjusting support to ensure that the injection port of the sample injection unit is just opposite to the standing wave suspension point of the ultrasonic standing wave suspension unit, and under the condition of inert gas, the sample injection unit works to inject reaction liquid to the standing wave suspension point of the ultrasonic standing wave suspension unit, so that various reaction liquids are mixed on the standing wave suspension point and the reaction speed is accelerated under the action of a sound field, and the non-contact reaction is realized.
Further limiting, the specific method for mixing various reaction liquids on the standing wave suspension point and accelerating the reaction speed under the action of the sound field is as follows: the exponential type vibration mode of the ultrasonic standing wave suspension unit is coupled with the spiral spring-like longitudinal vibration mode, so that various reaction liquids can be quickly gathered at a standing wave suspension point after being emitted, and the contact area is increased under the ultrasonic action.
The concrete method that various reaction liquids are mixed on the standing wave suspension point and the reaction speed is accelerated under the action of the sound field can be further limited as follows: different reaction liquids are injected on the standing wave suspension points of different ultrasonic standing wave suspension units, the positions of the ultrasonic standing wave suspension units are moved, the standing wave suspension points of the ultrasonic standing wave suspension units are adjusted to be overlapped, so that the different reaction liquids can be mixed on the overlapped standing wave suspension points, and the exponential type vibration mode of the ultrasonic standing wave suspension unit is coupled with the helical spring longitudinal vibration mode, so that the multiple reaction liquids can be rapidly gathered at the overlapped standing wave suspension points, the contact area is increased under the ultrasonic action, and the reaction is accelerated.
The non-contact liquid reaction method of the invention mainly utilizes the coupling of the stepped amplitude transformer structure and the spring-like constant-section amplitude transformer structure to superpose the exponential type vibration mode and the spiral spring-like longitudinal vibration mode to realize amplitude amplification and has good directive effect, so that a plurality of reaction liquids can be quickly gathered at a standing wave suspension point and uniformly mixed under the action of ultrasound after being emitted, thereby realizing non-contact reaction, avoiding the problem that the common chemical reaction causes larger errors to the reaction structure due to the cleaning of the container wall and the mechanical influence, and the reaction result, the reaction time and the reaction rate can be accurately controlled, thereby having no pollution, less investment, low cost, safety, cleanness and environmental protection, and being capable of realizing the breakthrough progress of intelligent operation, pollution-free, green and novel laboratory or precise production work by combining with the automatic control technology.
Drawings
Fig. 1 is a schematic structural diagram of a non-contact liquid ultrasonic suspension reaction apparatus of example 1.
Fig. 2 is a schematic view of the structure of the vibration horn of fig. 1.
FIG. 3 is a schematic view of the structure of a vibration horn of example 4.
Fig. 4 is a schematic view of a state in which particles are suspended between an emission end and a reflection end.
Fig. 5 is a schematic diagram of the total surface acoustic pressure field between the transmitting end and the reflecting end.
Detailed Description
The technical solution of the present invention will be further explained with reference to the accompanying drawings and examples.
Example 1
Referring to fig. 1, the non-contact liquid ultrasonic suspension reaction apparatus of the present embodiment includes a reactor 1 in which an inert gas is encapsulated, a first ultrasonic standing wave suspension unit 7, a second ultrasonic standing wave suspension unit 3, an ultrasonic reflection unit 5, a sample injection unit 4, a first adjusting bracket 6, a second adjusting bracket 2, and a sample adjusting bracket 8; wherein the reactor 1 is a glass or steel reactor vessel. The first ultrasonic standing wave suspension unit 7 is horizontally arranged at the bottom of the inner cavity of the reactor 1 through the first adjusting support 6, the second ultrasonic standing wave suspension unit 3 is vertically hung in the inner cavity of the reactor 1 through the second adjusting support 2, the second adjusting support 2 is fixed at the top of the reactor 1, and the second adjusting support 2 is a track facility, so that the second ultrasonic standing wave suspension unit 3 can be horizontally displaced. The spacing between the standing wave suspension points of the first ultrasonic standing wave suspension unit 7 and the spacing between the standing wave suspension points of the second ultrasonic standing wave suspension unit 3 are both 1.95cm, and the positions of the standing wave suspension points are integral multiples of the half wavelength of the ultrasound. The number of the corresponding ultrasonic reflection units 5 is 2, and the ultrasonic reflection units are respectively fixed at positions right opposite to the emission ends of the first ultrasonic standing wave suspension unit 7 and the second ultrasonic standing wave suspension unit 3 through mounting supports. The mutual distance between each ultrasonic standing wave suspension unit and the corresponding ultrasonic reflection unit 5 is 10.7mm and is not more than 3 times of half wavelength. The sample injection unit 4 is fixed by the sample adjusting bracket 8, and the injection angle can be adjusted by the sample adjusting bracket 8, so that the injection port of the sample injection unit 4 is opposite to the standing wave suspension point. The sample injection unit 4 is used for injecting a reaction solution, and comprises a plurality of sample injectors, and different reaction solutions are filled in different sample injectors during use.
Further, referring to fig. 2, each of the first ultrasonic standing wave suspension unit 7 and the second ultrasonic standing wave suspension unit 3 includes a piezoelectric ceramic stack 31, a vibration output rod 32, and a variable cross-section amplitude rod 33, which are sequentially arranged, the piezoelectric ceramic stack 31 is made of a lead zirconate titanate material with a diameter of 10.0mm and a height of 18.0mm, and a cross-sectional boundary of the piezoelectric ceramic stack 31 is grounded or terminated. The vibration output rod 32 is made of an aluminum circular straight pipe with the diameter of 10.0mm, 2 parallel spiral through grooves are formed in the side wall of the circular straight pipe to form a spring-like structure, starting points of the spiral through grooves are uniformly distributed on the same circumference, the spiral through grooves are left-handed spirals and can be right-handed spirals, the groove width of the spiral through grooves is 1mm, the helix lead angle is 45 degrees, the thread pitch is 32mm, and the number of the helix turns is 2. The variable cross-section amplitude transformer 33 comprises 2-stage sub amplitude transformers, the diameter of the first-stage sub amplitude transformer is 10mm, the length of the first-stage sub amplitude transformer is 25.7mm, the first-stage sub amplitude transformer is connected with the vibration output end of the vibration output rod 32, the diameter of the second-stage sub amplitude transformer is 4.4mm, the length of the second-stage sub amplitude transformer is 24.5mm, the emission end of the second-stage sub amplitude transformer is in a spherical crown shape, and two central angles of the emission end of the spherical crown shape are 150 degrees; the height h is 1.2mm and does not exceed 1/3 corresponding to the diameter of the sub-horn. The first ultrasonic standing wave suspension unit 7 and the second ultrasonic standing wave suspension unit 3 couple the variable cross-section amplitude transformer 33 structure with the spring-like constant cross-section amplitude transformer structure to superpose the exponential type vibration mode and the spiral spring-like longitudinal vibration mode, so that various reaction liquids can be rapidly gathered at a standing wave suspension point after being emitted, and the contact area is increased under the ultrasonic action.
Further, the sample adjusting rack 8 of the present embodiment is composed of a rail, a supporting leg and a spherical holder, the supporting leg is disposed on the rail and can move linearly along the rail, the spherical holder is fixed in the inner cavity of the reactor 1 through the supporting leg, the spherical holder is spherically hinged to the top end of the supporting leg, a groove is formed in the top end of the spherical holder for clamping the sample injection unit 4, and a rubber buffer layer is laid in the groove to ensure the stability of clamping.
Further, the sample injection unit 4 of this embodiment includes at least 2 reaction solution injectors, the housings of the reaction solution injectors are clamped and placed in the grooves of the spherical holders, and are clamped and fixed, the sample injection ports of the reaction solution injectors are opposite to the standing wave suspension points, and the distance between the standing wave suspension points is not less than 2 mm. The piston end of the reaction liquid injector extends to the outer side of the reactor 1 and can be connected with a transmission mechanism, so that automatic liquid injection is realized.
The method for realizing the liquid non-contact reaction by using the non-contact liquid ultrasonic suspension reaction device comprises the following steps:
(1) adjusting the first adjusting bracket 6 and the second adjusting bracket 2 to enable the transmitting end of the first ultrasonic standing wave suspension unit 7 to be opposite to the first ultrasonic reflection unit 5, the straight line distance is 10.7mm, and the transmitting end of the second ultrasonic standing wave suspension unit 3 is opposite to the second ultrasonic reflection unit 5; the vibration propagation direction of the first ultrasonic standing wave suspension unit 7 is perpendicular to that of the second ultrasonic standing wave suspension unit 3, the distance between the standing wave suspension points of the first ultrasonic standing wave suspension unit 7 and the distance between the standing wave suspension points of the second ultrasonic standing wave suspension unit 3 are both 1.95cm, and the standing wave suspension points of the first ultrasonic standing wave suspension unit 7 and the standing wave suspension points of the second ultrasonic standing wave suspension unit 3 are on the same horizontal straight line.
(2) The sample adjusting frame 8 is used for adjusting the horizontal and inclined angles of the sample injection unit 4, so that the injection port of the sample injector is opposite to the standing wave suspension point of the corresponding ultrasonic standing wave suspension unit, and the acoustic suspension force at the standing wave suspension point and the gravity of the reaction liquid drop meet the following requirements:
wherein: f denotes the acoustic levitation force, N
G represents the gravity of the reaction droplet, N;
f represents a wave number of
g represents the acceleration of gravity and is 9.8N/kg;
ρ0representing sound pressure amplitude in the sound field;
ρadenotes the density of the reaction droplets, g/cm3；
u0Representing the magnitude of the particle vibration velocity;
z represents the displacement of the particle in the vertical direction, cm;
when the wavelength is 9.0mm, the release diameter in the space is 7.1x10-4m, density 1g/cm3Droplets having a dynamic viscosity of 1 mPas and a particle surface tension of 0.0729N/m can be suspended.
(3) Under the condition of inert gas, the sample injection unit 4 works to respectively inject 2 reaction liquids to the standing wave suspension points of the first ultrasonic standing wave suspension unit 7 and the second ultrasonic standing wave suspension unit 3, the ultrasonic standing wave suspension unit couples the variable cross-section amplitude transformer 33 structure with the spring-like uniform cross-section amplitude transformer structure to enable the exponential type vibration mode and the spiral spring-like longitudinal vibration mode to be superposed, so that the 2 reaction liquids can be rapidly gathered at the standing wave suspension points after being emitted, the contact area is increased under the ultrasonic action, the reaction is accelerated, and the non-contact reaction is realized.
Example 2
The difference from the embodiment 1 is that: the non-contact liquid ultrasonic suspension reaction device of the embodiment comprises 3 ultrasonic standing wave suspension units, 3 corresponding ultrasonic reflection units 5, 2 reaction liquid injectors, wherein standing wave suspension points of the 3 ultrasonic standing wave suspension units are distributed on the same inclined line in a non-equidistant mode, and the distance between the standing wave suspension point of the first ultrasonic standing wave suspension unit 7 and the transmitting end of the first ultrasonic standing wave suspension unit 7 and the distance between the standing wave suspension point of the second ultrasonic standing wave suspension unit 3 and the transmitting end of the second ultrasonic standing wave suspension unit are 3 cm. The spacing between the standing wave suspension points of the first ultrasonic standing wave suspension unit 7 and the second ultrasonic standing wave suspension unit 3 was 0.99cm, and the spacing between the standing wave suspension points of the third ultrasonic standing wave suspension unit was 2.85 cm. The mutual distance between each ultrasonic standing wave suspension unit and the corresponding ultrasonic reflection unit 5 is 4.2 cm.
Further, the first ultrasonic standing wave suspension unit 7 and the second ultrasonic standing wave suspension unit 3 both include a piezoelectric ceramic stack 31, a vibration output rod 32 and a variable cross-section amplitude rod 33 which are sequentially arranged, the piezoelectric ceramic stack 31 is made of lead zirconate titanate material with the diameter of 15.0mm and the height of 23.0mm, and the cross-section boundary of the piezoelectric ceramic stack 31 is respectively grounded or terminated. The vibration output rod 32 is made of an aluminum circular straight pipe with the diameter of 15.0mm, 3 parallel spiral through grooves are formed in the side wall of the circular straight pipe to form a spring-like structure, starting points of the spiral through grooves are uniformly distributed on the same circumference, the spiral through grooves are left-handed spirals and can be right-handed spirals, the groove width of the spiral through grooves is 2mm, the helix lead angle is 45 degrees, the thread pitch is 32mm, and the number of the spiral turns is 3. The variable cross-section amplitude transformer 33 comprises 3-stage sub amplitude transformers, the diameter of the first-stage sub amplitude transformer is 15mm, the first-stage sub amplitude transformer is connected with the vibration output end of the vibration output rod 32, the diameter of the second-stage sub amplitude transformer is 10mm, the third-stage sub amplitude transformer is of a conical variable amplitude transformer structure, the diameter of the transmitting end is 4.4mm, the transmitting end is of a spherical crown shape, and two central angles of the spherical crown-shaped transmitting end are 150 degrees; the height h is 0.9 mm.
The other parts and their connection are the same as in example 1, and the liquid non-contact reaction method is the same as the procedure in example 1.
Example 3
The difference from the embodiment 1 is that: the non-contact liquid ultrasonic suspension reaction device of the embodiment comprises 2 ultrasonic standing wave suspension units, 2 ultrasonic reflection units 5 are correspondingly arranged, the 2 ultrasonic standing wave suspension units are obliquely arranged, the included angle between the ultrasonic standing wave suspension units is 45 degrees, and the included angle can also be adjusted between 30 degrees and 90 degrees. The number of the reaction solution injectors of this example was 3, and a reaction system was realized by using 3 kinds of reaction solutions.
The other parts and their connection are the same as in example 1, and the liquid non-contact reaction method is the same as the procedure in example 1.
Example 4
The difference from the embodiment 1 is that: the ultrasonic standing wave suspension unit of this embodiment includes piezoceramics heap 31, vibration output pole 32 and the variable cross-section amplitude transformer 33 that sets gradually, and the vibration output pole 32 of this embodiment is sandwich structure, see fig. 3, it includes 2 group class spring pipes promptly, and 2 group class spring pipes pass through excessive piece 34 of metal and connect, this type spring pipe adopts aluminium system circle straight tube to make, it constitutes spring-like structure to set up 3 parallel spiral through grooves on the lateral wall of circle straight tube, the starting point in spiral through groove is evenly distributed on same circumference, it is the same with embodiment 1 to the fluting parameter of spiral through groove. In the ultrasonic standing wave suspension unit of the embodiment, the variable cross-section amplitude transformer 33 structure is coupled with the spring-like constant cross-section amplitude transformer structure and the sandwich type amplitude transformer, so that an exponential type vibration mode and a spiral spring-like longitudinal vibration mode are realized, and chaotic fields are formed near a standing wave suspension point by ultrasound, so that various reaction liquids can be rapidly gathered at the standing wave suspension point after being emitted, the contact area is increased under the action of the ultrasound, the reaction is accelerated, and the non-contact reaction is realized.
The other components and their connection relationship are the same as those in embodiment 1.
Example 5
The difference from example 1 is that the liquid non-contact reaction method of this example comprises the steps of:
(1) adjusting the first adjusting bracket 6 and the second adjusting bracket 2 to enable the transmitting end of the first ultrasonic standing wave suspension unit 7 to be opposite to the first ultrasonic reflection unit 5, the straight line distance is 9mm, and the transmitting end of the second ultrasonic standing wave suspension unit 3 is opposite to the second ultrasonic reflection unit 5; the vibration propagation direction of the first ultrasonic standing wave suspension unit 7 is perpendicular to that of the second ultrasonic standing wave suspension unit 3, and the standing wave suspension point of the first ultrasonic standing wave suspension unit 7 and the standing wave suspension point of the second ultrasonic standing wave suspension unit 3 are on the same horizontal straight line, and the distance is 2.25 cm.
(2) The sample adjusting frame 8 is used for adjusting the horizontal and inclined angles of the sample injection unit 4, so that the injection port of the sample injector is opposite to the standing wave suspension point of the corresponding ultrasonic standing wave suspension unit, and the acoustic suspension force at the standing wave suspension point and the gravity of the reaction liquid drop meet the following requirements:
wherein: f denotes the acoustic levitation force, N
G represents the gravity of the reaction droplet, N;
f represents a wave number of
g represents the acceleration of gravity and is 9.8N/kg;
ρ0representing sound pressure amplitude in the sound field;
ρadenotes the density of the reaction droplets, g/cm3；
u0Representing the magnitude of the particle vibration velocity;
z represents the displacement of the particle in the vertical direction, cm;
when the wavelength is 9.0mm, the release diameter in the space is 7.1x10-4m, density 1g/cm3Droplets having a dynamic viscosity of 1 mPas and a particle surface tension of 0.0729N/m can be suspended.
(3) Under the condition of inert gas, a first reaction liquid is sequentially injected on each standing wave suspension point of a first ultrasonic standing wave suspension unit 7, a second reaction liquid is sequentially injected on each standing wave suspension point of a second ultrasonic standing wave suspension unit 3, the position of the second ultrasonic standing wave suspension unit 3 is adjusted, the standing wave suspension point of the first ultrasonic standing wave suspension unit 7 is overlapped with the standing wave suspension point of the second ultrasonic standing wave suspension unit 3, different reaction liquids can be mixed on the overlapped standing wave suspension points, and an exponential type vibration mode of the ultrasonic standing wave suspension unit is coupled with a helical spring longitudinal vibration mode, so that multiple reaction liquids can be rapidly gathered at the overlapped standing wave suspension points, contact areas are increased under the action of ultrasound, the reaction is accelerated, and non-contact reaction is realized.
The ultrasonic suspension reaction effect of the non-contact liquid ultrasonic suspension reaction apparatus of embodiment 1 of the present invention is simulated by software, and the simulation diagrams are shown in fig. 4 and 5.
As can be seen from fig. 4, which shows the suspension state of the particles between the emission end and the reflection end, the sample is injected from the sample injection unit, the emission end emits the acoustic field and is reflected by the reflection end, the acoustic field is formed between the emission end and the reflection end, and the injected sample can be in the multilayer suspension state as shown in the figure. It can be seen from fig. 5 that the intensity of the total surface acoustic pressure field between the transmitting end and the reflecting end is the weakest, and the sample is suspended at the weakest position of the total surface acoustic pressure field, and the simulation result conforms to the theoretical calculation.
The above embodiments are preferred embodiments of the present invention, wherein the detailed components, structures and connection modes of the bracket structure, the track structure and the adjusting structure, which are not described in detail, are conventional technologies, and can be implemented by referring to common technical means to meet the adjusting requirements of the present invention.
Claims (4)
1. A liquid non-contact reaction method realized by using a non-contact liquid ultrasonic suspension reaction device comprises a reactor (1) packaged with inert gas, wherein a plurality of ultrasonic standing wave suspension units, an ultrasonic reflection unit (5), a sample injection unit (4), an adjusting bracket and a sample adjusting bracket (8) are arranged in the reactor (1); the ultrasonic standing wave suspension unit is arranged on the adjusting bracket, the position of a standing wave suspension point between the ultrasonic standing wave suspension unit and the ultrasonic reflection unit (5) is adjusted through the adjusting bracket, and the ultrasonic emission ends of the ultrasonic standing wave suspension unit and the ultrasonic reflection unit (5) are in one-to-one correspondence and are arranged oppositely; the sample injection unit 4 is arranged on the sample adjusting frame (8), and the position and the angle of the sample injection unit (4) are adjusted through the sample adjusting frame (8), so that an injection port of the sample injection unit (4) is opposite to a standing wave suspension point of the ultrasonic standing wave suspension unit;
the ultrasonic standing wave suspension unit comprises a piezoelectric ceramic stack (31), a vibration output rod (32) and a variable cross-section amplitude transformer (33) which are sequentially arranged, wherein the variable cross-section amplitude transformer (33) comprises at least 2 stages of sub-amplitude transformers, the diameter of each stage of sub-amplitude transformer is smaller than or equal to that of the adjacent upper stage of sub-amplitude transformer, so that the sub-amplitude transformers are connected into a stepped amplitude transformer structure, at least 1 section of spring-like pipe formed by straight pipes with equal cross sections and provided with a plurality of spiral through grooves is arranged on the side wall of the spring-like pipe, and the cross section of the transmitting end of the last stage of sub-amplitude transformer is in a spherical crown shape; the central angle of the spherical crown-shaped transmitting end is 120-150 degrees; the height h does not exceed 1/3 corresponding to the diameter of the sub-horn;
the method is characterized by comprising the following steps:
adjusting an adjusting bracket to ensure that the transmitting end of an ultrasonic standing wave suspension unit is just opposite to an ultrasonic reflection unit 5, then adjusting the position and the inclination angle of a sample injection unit (4) by using a sample adjusting bracket (8) to ensure that an injection port of the sample injection unit (4) is just opposite to the standing wave suspension point of the ultrasonic standing wave suspension unit, under the condition of inert gas, the sample injection unit (4) works to inject reaction liquid to the standing wave suspension point of the ultrasonic standing wave suspension unit, different reaction liquids are injected to different standing wave suspension points of the ultrasonic standing wave suspension unit, the position of the ultrasonic standing wave suspension unit is moved, the standing wave suspension points of the ultrasonic standing wave suspension units are adjusted to coincide, different reaction liquids can be mixed on the coincident standing wave suspension points, and an exponential vibration mode of the ultrasonic standing wave suspension unit is coupled with a longitudinal vibration mode of a helical spring, so that a plurality of reaction liquids can be rapidly gathered on the coincident standing wave suspension points and contact area is increased under the action of ultrasound And (3) generating and accelerating the reaction to realize non-contact reaction.
2. The liquid non-contact reaction method realized by the non-contact liquid ultrasonic suspension reaction device according to claim 1, is characterized in that: starting points of the spiral through grooves in the spring-like pipe formed by the straight pipes with the same cross section and the plurality of spiral through grooves are uniformly distributed on the same circumferential line.
3. The liquid non-contact reaction method realized by the non-contact liquid ultrasonic suspension reaction device according to claim 1, is characterized in that: the sample injection unit (4) comprises at least 2 reaction liquid injectors, and the distance between each reaction liquid injector and the standing wave suspension point of the ultrasonic standing wave suspension unit is not less than 2 mm.
4. The liquid non-contact reaction method realized by the non-contact liquid ultrasonic suspension reaction device according to claim 3, is characterized in that: the distance between the standing wave suspension points of the ultrasonic standing wave suspension unit is 0.95-2.85 cm.
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