CN110277301A - A kind of air pressure inside ion trap unevenly distributed and its working method - Google Patents
A kind of air pressure inside ion trap unevenly distributed and its working method Download PDFInfo
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- CN110277301A CN110277301A CN201910579183.XA CN201910579183A CN110277301A CN 110277301 A CN110277301 A CN 110277301A CN 201910579183 A CN201910579183 A CN 201910579183A CN 110277301 A CN110277301 A CN 110277301A
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- ion trap
- ion
- electrode
- trap
- field center
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/426—Methods for controlling ions
Abstract
The invention discloses a kind of air pressure inside ion trap unevenly distributed and its working methods, it include: to offer air inlet (1,2,3,4,5,6,7,8,9) on an electrode wherein, for being passed through background gas toward ion trap inner space, and the airintake direction of background gas does not intersect with the field center region of ion trap, to construct the zone of pressure (10,20,30) least partially overlapped with moving region (100) when ion cooling, so that ion collides the zone of pressure (10,20,30) in cooling procedure and reduces kinetic energy.In the whole work process of ion trap, alternatively, being passed through background gas in ion trap by the air inlet in ion incidence and cooling stage.
Description
Technical field
The present invention relates to ion trap mass spectrometer fields, more particularly, to a kind of air pressure inside ion trap unevenly distributed.
Background technique
Ion trap analyzer is one of core component of ion trap mass spectrometer, the course of work can be divided into ion incidence,
Ion cooling (ion binding), ion analysis (outgoing), ion remove four-stage.If ion can be held onto more when cooling
More ions, the then available better signal strength in ion analysis, so that mass spectrograph has better performance.For
Complex sample or ion trap analyzer are directly analyzed using the pretreatment of few or no sample, mass spectrometric miniaturization, this is all non-
It is often important.
The disclosure of background above technology contents is only used for auxiliary and understands inventive concept and technical solution of the invention, not
The prior art for necessarily belonging to present patent application shows above content in the applying date of present patent application in no tangible proof
Before have disclosed in the case where, above-mentioned background technique should not be taken to evaluation the application novelty and creativeness.
Summary of the invention
It is a primary object of the present invention to propose a kind of air pressure inside ion trap unevenly distributed and its working method, with
The sensitivity for improving miniaturization, integrated ion trap mass spectrometer, for using few or no sample pretreatment directly analysis multiple
Miscellaneous sample is extremely important, also extremely important for the performance for improving small spectrometer.
The present invention proposes following technical scheme for the above-mentioned purpose:
A kind of air pressure inside ion trap unevenly distributed, several metal electrodes including surrounding ion trap inner space,
Offer air inlet on an electrode wherein, for being passed through background gas toward ion trap inner space, and background gas into
Gas direction does not intersect with the field center region of ion trap, the least partially overlapped gas in moving region when cooling with ion with construction
Pressure zone, so that ion collides the zone of pressure in cooling procedure and reduces kinetic energy.
Further:
The field center region and the type of ion trap in relation to: when the type of the ion trap is cylindrical ion trap,
The field center region is a point；When the type of the ion trap is linear ion hydrazine or rectilinear ion trap, the electricity
Field central area is a line；When the type of the ion trap is annular ion trap, the field center region is a circle
Shape.
When the ion trap is cylindrical ion trap, several metal electrodes include the end cap electricity at side-wall electrode and both ends
Pole；When the ion trap is annular ion trap, several metal electrodes include the end cap electricity at two round loop electrodes and both ends
Pole；When the ion trap is rectilinear ion trap or linear ion hydrazine, several metal electrodes include four side-wall electrodes and
The endcap electrode at both ends.
When the ion trap is cylindrical ion trap, the endcap electrode and the side-wall electrode at least one of them and electricity
Field center opens up ion exit slit on corresponding position, and the air inlet is opened on a wherein endcap electrode or the side wall
On electrode, and the airintake direction of background gas deviates from the field center region and ion exit direction；When the ion
When trap is annular ion trap, on the endcap electrode and round loop electrode at least one of them position corresponding with field center
Open up ion exit slit, the air inlet is located therein on an endcap electrode or a round loop electrode, and background gas into
Gas direction deviates from the field center region and ion exit direction；When the ion trap be rectilinear ion trap or linearly from
When sub- trap, ion exit slit is opened up on at least one of them position corresponding with field center of four side-wall electrodes,
The air inlet is opened on a wherein endcap electrode or in which on a side-wall electrode, and the airintake direction of background gas is inclined
From in the field center region and ion exit direction.
The offset distance that the airintake direction of background gas deviates the field center region is preset value d, d a value and ion
The radial dimension of trap is positively correlated.
The air inlet is poroid, arcuate slots shape or annular shape.The quantity of poroid air inlet is one or more.
The present invention separately also proposes the working method of the non-uniform ion trap of aforementioned inner gas pressure distribution, comprising: in ion trap
Whole work process in, alternatively, being passed through background gas in ion trap by the air inlet in ion incidence and cooling stage
Body.
Preceding solution proposed by the present invention carries out cleverly structure in the structure basis of existing ion trap and repairs
Change, i.e., open up background gas air inlet in place, and be passed through background gas in ion trap, can in ion trap structure
Hyperbar band is produced, so, in ion cooling procedure, the ion that constantly moves can be with when colliding the gas of hyperbar band
Kinetic energy is reduced, so that being conducive to more ions is bound to field center, and then the signal in ion analysis can be improved
Intensity.On the other hand, ion exit is moved from field center toward ion exit slit, and background gas airintake direction of the present invention is not
Intersect and deviate ion exit direction with ion trap electric field central area, this all to be passed through background gas in whole work process
Working method under, can avoid as far as possible zone of pressure influence ion outgoing.In short, the present invention is conducive to improve miniaturization, collection
At the sensitivity of the ion trap mass spectrometer of change.
Detailed description of the invention
Fig. 1 is that a kind of stereochemical structure of cylindrical ion trap that 1 air inlet is illustratively opened up on endcap electrode is shown
It is intended to；
Fig. 2 is the left view of ion trap shown in Fig. 1；
Fig. 3 is the cross-sectional view of line A-A in Fig. 2；
Fig. 4 is the internal schematic illustration for forming hyperbar band under ion trap shown in FIG. 1 visual angle shown in Fig. 3；
Fig. 5 is the main view that the cylindrical ion trap of two air inlets is opened up on side-wall electrode；
Fig. 6 is the cross-sectional view of line B-B in Fig. 5；
Fig. 7 is that a kind of stereochemical structure of cylindrical ion trap that 2 air inlets are illustratively opened up on endcap electrode is shown
It is intended to；
Fig. 8 is the left view of ion trap shown in Fig. 7；
Fig. 9 is the cross-sectional view of line A-A in Fig. 8；
Figure 10 is the internal schematic illustration for forming hyperbar band under ion trap shown in Fig. 7 visual angle shown in Fig. 9；
Figure 11 is a kind of standing for cylindrical ion trap that 1 circular ring shape air inlet slit is illustratively opened up on endcap electrode
Body structural schematic diagram；
Figure 12 is a kind of stereochemical structure signal of rectilinear ion trap that air inlet slit is illustratively opened up on side-wall electrode
Figure；
Figure 13 is a kind of schematic perspective view of rectilinear ion trap that air inlet is illustratively opened up on endcap electrode；
Figure 14 is a kind of schematic perspective view of rectilinear ion trap that air inlet is illustratively opened up on endcap electrode.
Specific embodiment
The invention will be further described with specific embodiment with reference to the accompanying drawing.
The course of work of ion trap analyzer includes that ion is cooling and ion analysis, when ion is cooling, the air pressure that needs compared with
It is high；When ion analysis, the air pressure needed is lower, and current ion trap, and air pressure can not be allowed in the two stepwise mutations.In this regard,
The invention proposes a kind of air pressure inside ion traps unevenly distributed, are passed through by the way that air inlet is arranged in the specific band of position
Background gas constructs hyperbar band, makes the hyperbar band close to field center region (and center of ion binding), but simultaneously
It is staggered with ion exit direction.In this way, the sample ions in movement when encountering hyperbar band and are carried on the back when carrying out ion cooling
Scape gas collisions can be with kinetic energy loss, so as to allow more ions to be efficiently bound by field center, to improve ion
The signal strength of analysis phase simultaneously because hyperbar band avoids the exit direction of ion, therefore works in entire ion trap
It is passed through the analysis scanning process that background gas nor affects on ion in the process.
For this purpose, specific technical solution proposed by the present invention is: opening up one or two on one of electrode of ion trap
A above air inlet, the position which is opened up are determined according to the shape of different ion trap types and its electrode, only
The airintake direction of background gas is wanted not intersect with the field center region of ion trap, in order to avoid in whole work process
Be passed through background gas nor affect on ion analysis scanning (outgoing) function, the air inlet position of background gas also need to guarantee into
Deviate ion exit direction so that zone of pressure is avoided with the direction of ion exit as far as possible in gas direction.So, just construct with
The least partially overlapped zone of pressure in ion moving region locating when cooling, so that ion collides the air pressure in cooling procedure
Band and reduce kinetic energy.
Ion trap of the present invention, generally includes the endcap electrode at side-wall electrode and both ends, they surround ion jointly
Trap.The present invention does not make specific limitation to the type of ion trap and electrode shape, and the type of ion trap for example can be cylinder
Shape ion trap, linear ion hydrazine, rectilinear ion trap or annular ion trap etc., and the shape of electrode is not limited to plate electrode, hyperbolic
Line electrode, cylindrical electrode, arc-shaped electrode or the polygonal electrodes even electrode of other irregular structures.
In addition, the field center region is related with the type of ion trap:
When the type of ion trap is cylindrical ion trap, the field center region is a point, if the cylindrical ion
Trap be it is symmetrical, then the field center is then the geometric center of ion trap, if asymmetric, needs specifically to be calculated to determine
Field center point, specific method of determination are the prior art, and details are not described herein；
When the type of ion trap is linear ion hydrazine or rectilinear ion trap, the field center region is a line；If
The linear ion hydrazine or rectilinear ion trap be it is symmetrical, then the field center line is then by the symmetrical of ion trap geometric center
Axis needs specifically to be calculated to determine field center line, specific method of determination is the prior art, herein if asymmetric
It repeats no more；
When the type of ion trap is annular ion trap, the field center region is a circle；If the annular ion
Trap is symmetrical, then is ion trap geometric center point as the circular center of circle of field center, with the circle in the middle part of annular ion trap
Shape is coplanar；If asymmetric, need specifically to be calculated to determine field center region, specific method of determination is existing skill
Art, details are not described herein.
In short, we can open up background according to different types of ion trap and its electrode shape in different location areas
Gas access.Size is bigger, then the size in gas access deviation field center region is bigger.Below by several specific examples
Technical solution of the present invention and principle to be described in detail.
As shown in Figure 1, being a cylindrical ion trap, surrounded by side-wall electrode 40 and two endcap electrodes 51,52.Such as figure
1 into example shown in Fig. 4, opens up an air inlet 1 on an endcap electrode 51 wherein, on another endcap electrode 52 with electric field
Ion exit slit 60 is opened up at the corresponding position in center, or is opened at position corresponding with field center on side-wall electrode 40
If ion exit slit (not shown).Since the ion trap is symmetrical structure, field center point O is in the geometry of ion trap
The heart, in order to construct a hyperbar band in ion trap and not influence the outgoing of ion, air inlet 1 deviates in electric field radially
The heart so forms hyperbar band 10, and hyperbar band when ion is cooling in moving region 100 when being passed through background gas
10 are staggered with ion exit direction, also offset from field center region.Concrete shape of the distance of deviation according to ion trap, size thing
It first sets, the more big then deviation value of the radial dimension of ion trap can be bigger.The quantity of the air inlet opened up can with more than one,
As shown in Figure 7 to 10, then air inlet 4 and 5 there are two opening up, two are accordingly formed in ion trap has weight with region 100
Folded hyperbar band 20 and 30, similarly, as long as guaranteeing that the zone of pressure formed in ion trap does not produce as far as possible with ion exit direction
It is raw to intersect.In this embodiment, air inlet can also be provided on side-wall electrode, as shown in Figure 5 and Figure 6, in side wall electricity
Two air inlets 2 and 3 are opened up on pole 40, similarly, as long as guaranteeing the zone of pressure formed in ion trap and ion exit direction
Intersection is not generated as far as possible.
Air inlet is poroid in addition to can be, and is also possible to elongated arcuate slots, or circular.Such as shown in Figure 11
In embodiment, the slit 6 of an annular is opened up on endcap electrode, when being passed through background gas from the slit 6, airintake direction deviates
Field center is formed by zone of pressure and does not intersect with ion exit direction according to the slit that pre-designed deviation value opens up,
The outgoing of ion is not influenced.
Similar with cylindrical ion trap above-mentioned, annular ion trap includes the endcap electrode of two round loop electrodes and both ends,
In, open up ion exit slit on endcap electrode and round loop electrode at least one of them position corresponding with field center, and into
Port is located therein on an endcap electrode or a round loop electrode, and the airintake direction of background gas deviates from the field center
Region and ion exit direction.
The present invention in addition to be suitable for foregoing cylindrical ion trap and annular ion trap, apply also for rectilinear ion trap and linearly from
The structure of sub- trap, rectilinear ion trap and both linear ion hydrazines is similar, is enclosed by four side-wall electrodes and two endcap electrodes
At being only that electrode shape is had any different, therefore exit slit is as the Position Design principle of air inlet, herein with rectilinear ion trap
For be illustrated.The case where Figure 12 to Figure 14 illustrates rectilinear ion trap, rectilinear ion trap include four side-wall electrodes (in figure
Longer four) and two endcap electrodes 61,62.As shown in figure 12, the ion exit slit 60 ' of rectilinear ion trap is opened in one
On side-wall electrode at position corresponding with field center, while (deviateing outgoing near exit slit 60 ' on the side-wall electrode
The deviation value of slit is equally preset) background gas that opens up a more refinement than exit slit enters slit 7.Similarly,
The band of position of slit is calculated previously according to the shape and size of ion trap, deviates electricity to guarantee that background gas forms zone of pressure
Field center line and ion exit direction.In Figure 13, unlike Figure 12, background gas entrance is changed to lid electrode 61 at one end
On, i.e. air inlet 8.In Figure 14, unlike Figure 12, background gas entrance is changed on another side-wall electrode, i.e. air inlet is narrow
Seam 9, with ion exit slit 60 ' not on the same side-wall electrode.
The air pressure inside ion trap unevenly distributed of the aforementioned offer of the present invention, in the whole work process of ion trap,
Alternatively, background gas is passed through in ion trap by the air inlet, to construct ion in ion incidence and cooling stage
Uneven air pressure space in trap, ion motion can collide gas and kinetic energy loss when cooling, improve ion binding efficiency；
And when ion exit, and hyperbar band can be avoided.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those skilled in the art to which the present invention belongs, it is not taking off
Under the premise of from present inventive concept, several equivalent substitute or obvious modifications can also be made, and performance or use is identical, all answered
When being considered as belonging to protection scope of the present invention.
Claims (8)
1. a kind of air pressure inside ion trap unevenly distributed, several metal electrodes including surrounding ion trap inner space,
It is characterized in that:
It is offered on an electrode wherein air inlet (1,2,3,4,5,6,7,8,9), for being passed through toward ion trap inner space
Background gas, and the airintake direction of background gas does not intersect with the field center region of ion trap, when cooling with ion with construction
The least partially overlapped zone of pressure in moving region (100) (10,20,30), so that ion collides the air pressure in cooling procedure
Kinetic energy is reduced with (10,20,30).
2. air pressure inside ion trap unevenly distributed as described in claim 1, which is characterized in that the field center region
It is related with the type of ion trap:
When the type of the ion trap is cylindrical ion trap, the field center region is a point (O)；
When the type of the ion trap is linear ion hydrazine or rectilinear ion trap, the field center region is a line；
When the type of the ion trap is annular ion trap, the field center region is a circle.
3. air pressure inside ion trap unevenly distributed as claimed in claim 1 or 2, it is characterised in that: when the ion trap
When for cylindrical ion trap, several metal electrodes include the endcap electrode at one side wall electrode and both ends；When the ion trap is
When annular ion trap, several metal electrodes include the endcap electrode of two round loop electrodes and both ends；When the ion trap is
When rectilinear ion trap or linear ion hydrazine, several metal electrodes include the endcap electrode of four side-wall electrodes and both ends.
4. air pressure inside ion trap unevenly distributed as claimed in claim 3, it is characterised in that:
When the ion trap is cylindrical ion trap, in the endcap electrode and the side-wall electrode at least one of them and electric field
Ion exit slit is opened up on the corresponding position of the heart, the air inlet is opened on a wherein endcap electrode or the side-wall electrode
On, and the airintake direction of background gas deviates from the field center region and ion exit direction；
When the ion trap is annular ion trap, in the endcap electrode and the round loop electrode at least one of them and electric field
Ion exit slit is opened up on the corresponding position of the heart, the air inlet is located therein on an endcap electrode or a round loop electrode,
And the airintake direction of background gas deviates from the field center region and ion exit direction；
When the ion trap is rectilinear ion trap or linear ion hydrazine, at least one of them and electricity of four side-wall electrodes
Field center opens up ion exit slit on corresponding position, and the air inlet is opened on a wherein endcap electrode or in which an institute
It states on side-wall electrode, and the airintake direction of background gas deviates from the field center region and ion exit direction.
5. air pressure inside ion trap unevenly distributed as claimed in claim 4, it is characterised in that: the air inlet side of background gas
It is the radial dimension positive correlation of preset value d, d a value and ion trap to the offset distance for deviateing the field center region.
6. air pressure inside ion trap unevenly distributed as described in claim 1, it is characterised in that: the air inlet is hole
Shape, arcuate slots shape or annular shape.
7. air pressure inside ion trap unevenly distributed as claimed in claim 6, it is characterised in that: the quantity of poroid air inlet
For one or more.
8. the working method of air pressure inside ion trap unevenly distributed as described in any one of claim 1 to 7, feature exist
In, comprising: in the whole work process of ion trap, alternatively, in ion incidence and cooling stage, by the air inlet toward from
Background gas is passed through in sub- trap.
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| Publication number | Publication date |
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| CN110277301B (en) | 2021-10-26 |
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