CN110269896A - A kind of Chinese medicine composition for preventing and treating chronic liver disease and jaundice - Google Patents
A kind of Chinese medicine composition for preventing and treating chronic liver disease and jaundice Download PDFInfo
- Publication number
- CN110269896A CN110269896A CN201910727920.6A CN201910727920A CN110269896A CN 110269896 A CN110269896 A CN 110269896A CN 201910727920 A CN201910727920 A CN 201910727920A CN 110269896 A CN110269896 A CN 110269896A
- Authority
- CN
- China
- Prior art keywords
- parts
- jaundice
- liver disease
- chinese medicine
- chronic liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention proposes a kind of prevention and treatment chronic liver disease and the Chinese medicine compositions of jaundice, are made of following raw material according to parts by weight: tag 10-20 parts processed, 10-20 parts of ginseng tablet, 15-30 parts of radix paeoniae rubra, 10-15 parts of rheum officinale, 15-30 parts of oriental wormwood, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 8-10 parts of Poria cocos, 3-8 parts of Radix Glycyrrhizae and 10-15 parts of radix rehmanniae preparata.The main object of the present invention is to improve the clinical treatment predicament of current chronic liver disease burst jaundice illness, with strengthening YANG and invigorating YIN, detoxification and removing stasis, the raw new response to treatment of kidney tonifying, it is with the obvious advantage, cheap to accelerate jaundice recession, curative effect to improve liver regeneration microenvironment.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine, and in particular to a kind of Chinese medicine group for preventing and treating chronic liver disease and jaundice
Close object.
Background technique
Chronic liver disease continuing advances necessarily lead to the occurrence and development of the severe liver diseases such as cirrhosis, hepatic failure and liver cancer, directly
It connects or causes sufferer dead indirectly, occurring jaundice illness on the basis of chronic liver disease is the important sign that disease burst deteriorates, mesh
Preceding Western medicine colligation treatment means are broadly divided into etiological treatment, suit the medicine to the illness supportive treatment and many aspects, the clinical efficacy such as anti-infective have
Limit, medical expense is high, and easy to recur after treatment.Traditional Chinese medicine is in treatment jaundice illness bright characteristic at present, but there is also curative effects
Unstable, the long-time service insufficient defect of reliability.
Body mesh xanthochromia is that the main feature of jaundice illness liver then occurs after being liver cell Large Scale Death at all
Dirty hypoxic-ischemic damage, microcirculation disorder, immunologic mjury are so that liver metabolism and function of detoxification deteriorate comprehensively, it may be said that slow
Property hepatopathy on the basis of occur jaundice illness be disease burst deteriorate important sign.For this purpose, improving hepatic ischemia/reperfusion injury anoxic damage simultaneously
Microcirculation disorder is injured, balance regulation immune response, improving liver regeneration microenvironment to promote liver cell regeneration is that jaundice is controlled
Vision is treated, but current Western medicine colligation treatment means there is no effective treatment method at several aspects as above.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of Chinese traditional medicine composition for preventing and treating chronic liver disease and jaundice
Object it is intended that improving the clinical treatment predicament of current chronic liver disease burst jaundice illness there is strengthening YANG and invigorating YIN, removing toxic substances to dispel
The stasis of blood, the raw new response to treatment of kidney tonifying, it is with the obvious advantage, cheap to accelerate jaundice recession, curative effect to improve liver regeneration microenvironment.
The present invention provides the Chinese medicine composition of a kind of prevention and treatment chronic liver disease and jaundice, including following raw material: tag processed, people
Join piece, radix paeoniae rubra, rheum officinale, oriental wormwood, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix rehmanniae preparata and Radix Glycyrrhizae.
As further improvement of the invention, it is made of following raw material according to parts by weight: tag 10-20 parts processed, ginseng tablet
10-20 parts, 15-30 parts of radix paeoniae rubra, 10-15 parts of rheum officinale, 15-30 parts of oriental wormwood, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 8-10 parts of Poria cocos, 3-8 parts of Radix Glycyrrhizae
With 10-15 parts of radix rehmanniae preparata.
It improves as of the invention further, is made of following raw material according to parts by weight: 10 parts of tag processed, ginseng tablet 10
Part, 20 parts of radix paeoniae rubra, 8 parts of rheum officinale, 20 parts of oriental wormwood, 10 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Poria cocos, 3 parts of Radix Glycyrrhizae and 10 parts of radix rehmanniae preparata.
The present invention further protects a kind of preparation method of Chinese materia medica preparation for preventing and treating chronic liver disease and jaundice, institute on raw material
State, preparation method the following steps are included:
S1. microwave radiation exaraction: Chinese medicine being weighed in proportion, cleaning, drying, is crushed, is obtained traditional Chinese medicine powder；By traditional Chinese medicine powder
With water according to solid-to-liquid ratio 1: (20-50) is mixed, and after impregnating 2-3h, microwave heating while stirring extracts 60- to 35-40 DEG C
120min stops heating after extraction, cooling, filtering, obtained extracting solution A；
S2. solid-fermented technique: by the solid obtained after the filtering of S1 step it is dry after, the PBS that sprinkling pH is 6.7 is buffered
Liquid, starting moisture 35% are inoculated with Lactobacillus casei, enterococcus faecalis and Trametes robiniphila Murr, and after the 72h that ferments at 37 DEG C, then inactivation will
The mass mixings such as solid and water, after microwave heating to 35-40 DEG C of stirring 10-20min, filtering, obtained extracting solution B；
S3. the preparation of Chinese medicine: extracting solution A and extracting solution B is mixed, and is concentrated under reduced pressure, and medicinal extract is obtained, and auxiliary material is added and does by spraying
Dry, granulation obtains the Chinese materia medica preparation of prevention and treatment chronic liver disease and jaundice
As further improvement of the invention, the speed of agitator is 300-500r/min.
As further improvement of the invention, the inoculum concentration of the Lactobacillus casei is 10%, and the enterococcus faecalis connects
Kind amount is 15%, and the inoculum concentration of the Trametes robiniphila Murr is 20%.
As further improvement of the invention, the power of the microwave heating is 500-700W.
The present invention further protects a kind of above-mentioned preparation method Chinese medicine system obtained for preventing and treating chronic liver disease and jaundice
Agent.
The present invention further protects a kind of above-mentioned Chinese medicine composition answering in prevention and treatment chronic liver disease and the drug of jaundice
With.
The present invention further protects a kind of application of above-mentioned Chinese materia medica preparation in prevention and treatment chronic liver disease and the drug of jaundice.
Clinical common dosage forms can be made in Chinese medicine composition of the present invention according to a conventional method, for example, by using conventional heat
Water extracts concentration method, obtains intermediate medicinal extract.Certain auxiliary material is added, the oral preparations of different dosage forms can be obtained.The agent of the preparation
The oral solid formulations such as type, including tablet, granule, capsule.
The dosage and the course for the treatment of of the traditional chinese medicine composition of the invention or Chinese materia medica preparation can according to dosage form, the age of patient, disease it is light
Weight degree appropriately adjusts, but generally daily 3 times oral, and 3-5 each (piece) (bag) (bottle) is as a treatment course with 3 months,
2 courses for the treatment of or longer time can be used continuously.
The further object of the present invention is to provide purposes of the Chinese medicine composition in the drug of prevention and treatment chronic liver disease.It is described
Chronic liver disease include chronic hepatitis, liver fibrosis, cirrhosis, liver neoplasm etc..
In each taste Chinese medicine of above-mentioned formula:
Tag processed: pungent, sweet, big heat；Major function: recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.It collapses for yang depletion,
Cold weak pulse of limb, impotence, palace cold, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.
Ginseng tablet: sweet in flavor, slight bitter, it is warm-natured, flat；Major function: replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, promote the production of body fluid, pacifies
Mind.It to be taken off for physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, injury thirst, Heat Diabetes, prolonged illness virtual winning, and palpitation with fear is lost
It sleeps, impotence palace cold；Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hidrosis, deficiency of food is powerless, all
Caused shock, collapse after acute and chronic diseases and blood loss.It reinforces vital energy, prevent prolapse and engender liquid is calmed the nerves.It is deficient to control internal lesion caused by overexertion, deficiency of food is tired
Idle, regurgitation and emesis, slipping diarrhea of defecating, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitation with fear, amnesia, dizziness and headache, impotence, frequent micturition quenches one's thirst, women
Metrorrhagia and metrostaxis, infantile chronic fright and perennial and irrecoverable weakness, the card of all qi-blood-body fluid deficiencies.
Radix paeoniae rubra: bitter, cold nature；Major function: clearing heat and cooling blood, removing blood stasis and acesodyne；For being used for thermal man's ying blood, epidemic heat syndrome hair
Spot, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, amenorrhea and algomenorrhea, addiction lump in the abdomen abdominal pain, injury from falling down, carbuncle swells sore.
Rheum officinale: bitter, cold；Major function: attacking stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances；For real heat constipation, heat
Accumulation of pathogens in chest ruffian, damp-heat dysentery, jaundice, stranguria syndrome, oedema abdomen be full, difficult urination, hot eyes, abscess of throat, aphthae, gastropyretic vomiting,
Haematemesis, stores blood, menostasis, postpartum stasis abdominal pain, lumps in the chest and abdomen, traumatic injury, heat toxin large carbuncle, pellet at hemoptysis, bleeding from five sense organs or subcutaneous tissue, hematochezia, hematuria
Poison, scald.
Oriental wormwood: it is bitter, pungent, it is slightly cold；Major function: clearing away damp-heat, removing jaundice subcutaneous ulcer.For jaundice oliguria, itchy sore；Infectiousness is yellow
Subcutaneous ulcer type hepatitis.
Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm；Major function: strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention.For spleen eating less, abdominal distension
Diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, threatened abortion.Rhizoma Atractylodis Macrocephalae invigorating the spleen, stomach function regulating, miscarriage prevention.For spleen eating less, diarrhea loose stool,
Threatened abortion.
Poria cocos: it is sweet, light, it puts down；Major function: clearing damp and promoting diuresis, invigorating the spleen calming heart.For edema and little urine, phlegm retention anti-dazzle nervous, spleen deficiency food
It is few, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Radix rehmanniae preparata: sweet, tepor；Major function: nourishing yin and supplementing blood, beneficial to spirit and marrow.For the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, hectic fever due to yin tide
Heat, night sweat spermatorrhea, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, tinnitus, poliosis.
Radix Glycyrrhizae: sweet and neutral；Major function: invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For
It is weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviation drug toxicity,
It is strong.
Recipe characteristics of combination: since three layers of therapy of treatise on Febrile Diseases jaundice (in table: Mahuang Lianqiao Chixiaodou Tang, inner:
It is Yinchenhao Tang, Oriental Wormwood Decoction, semi-exterior-interior: Yinchen Wuling San, Powder of Oriental Wormwood and Five Drugs with Poria), later age treat chronic liver disease and jaundice (yin jaundice) mostly in Yinchen Wuling San, Powder of Oriental Wormwood and Five Drugs with Poria and
Variation is added and subtracted between Yinchen Shufu Decoction.On the full appreciation disease etiology and pathogenesis basis, there are several points that must be paid close attention to: one
On the basis of chronic liver disease and jaundice its void is then certainty, secondly the long-term reform organization of liver certainly will lead to hemostasis, phlegm
Turbid retardance, third, prolonged illness will tire out kidney, damage of kidney-essence.3 points of shorter mentions in the Chinese medicine preparation of the past as above, even if
Concern, also flavour of a drug are various, and effect is heterogeneous, and the functional characteristic of Chinese medicine loses to the greatest extent.This Chinese medicine preparation medicine letter submitted, power are macro, effect
Single-minded, wherein tag processed helps positive warm kidney, ginseng tablet's qi-restoratives is negative by force, and radix rehmanniae preparata kidney tonifying, essence replenishing, three medicines share the root for directing at this disease；It is red
Internal organs is led in Chinese herbaceous peony activating microcirculation and removing stasis medicinal and cool blood, the clearing heat and detoxicating removing jaundice of oriental wormwood, rheum officinale stagnation resolvation, and three medicines share activating microcirculation and removing stasis medicinal heat-clearing removing jaundice；Rhizoma Atractylodis Macrocephalae
It is drying damp and strengthening spleen, Poria cocos excreting dampness invigorating the spleen, Radix Glycyrrhizae coordinating the drug actions of a prescription, three medicines share in invigorating the spleen and transporting it is burnt, can long term usage.Recipe combination is direct
For the disease this (caused by liver and kidney deficiency, yang-energy is deficient, kidney essence deficiency), power removes the mark (bile overflows, stagnation of blood stasis) of this disease, and simultaneous
Burnt spleen soil in Gu (see the disease real spleen in the ban of liver) is the Special Traditional Chinese Medicine formula for preventing and treating chronic liver disease simultaneously jaundice.With original wound
New property and wide application prospect.
It is to improve current chronic liver disease burst jaundice illness the invention has the following beneficial effects: the main object of the present invention
Clinical treatment predicament, with strengthening YANG and invigorating YIN, detoxification and removing stasis, the raw new response to treatment of kidney tonifying, can improve liver regeneration microenvironment with
It is with the obvious advantage, cheap to accelerate jaundice recession, curative effect.
Detailed description of the invention
Fig. 1 is the preparation technology figure of Chinese materia medica preparation of the embodiment of the present invention；
Fig. 2 is that each group rat blood serum ALT level compares figure in test case 1 of the present invention；
Fig. 3 is that each group rat blood serum AST level compares figure in test case 1 of the present invention；
Fig. 4 is each group liver tissues of rats HE colored graph in test case 1 of the present invention.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, the embodiment described is the embodiment of part of representative of the invention, rather than whole embodiments, this field are general
Other all embodiments obtained belong to protection of the invention to logical technical staff without making creative work
Range.
Embodiment 1
Raw material forms (parts by weight): 10 parts of tag processed, 10 parts of ginseng tablet, 15 parts of radix paeoniae rubra, 10 parts of rheum officinale, 15 parts of oriental wormwood, white
10 parts of art, 8 parts of Poria cocos, 3-8 parts of Radix Glycyrrhizae and 10 parts of radix rehmanniae preparata.
Preparation method the following steps are included:
S1. microwave radiation exaraction: Chinese medicine being weighed in proportion, cleaning, drying, is crushed, is obtained traditional Chinese medicine powder；By traditional Chinese medicine powder
It is mixed with water according to solid-to-liquid ratio 1: 20, after impregnating 2h, 300r/min stirring, 500W microwave heating is extracted 60min, mentioned to 35 DEG C
Stop heating after taking, cooling, filtering, obtained extracting solution A；
S2. solid-fermented technique: by the solid obtained after the filtering of S1 step it is dry after, the PBS that sprinkling pH is 6.7 is buffered
Liquid, starting moisture 35%, inoculation Lactobacillus casei, enterococcus faecalis and Trametes robiniphila Murr, the inoculum concentration of the Lactobacillus casei are
10%, the inoculum concentration of the enterococcus faecalis is 15%, and the inoculum concentration of the Trametes robiniphila Murr is 20%, ferments after 72h, goes out at 37 DEG C
Living, then by the mass mixings such as solid and water, 500W microwave heating is to 35 DEG C, and after 300r/min stirs 10min, filtering is obtained
Extracting solution B；
S3. the preparation of Chinese medicine: extracting solution A and extracting solution B is mixed, and is concentrated under reduced pressure, and medicinal extract is obtained, and auxiliary material is added and does by spraying
Dry, granulation obtains the Chinese materia medica preparation of prevention and treatment chronic liver disease and jaundice.
Embodiment 2
Raw material forms (parts by weight): 20 parts of tag processed, 20 parts of ginseng tablet, 30 parts of radix paeoniae rubra, 15 parts of rheum officinale, 30 parts of oriental wormwood, white
20 parts of art, 10 parts of Poria cocos, 8 parts of Radix Glycyrrhizae and 15 parts of radix rehmanniae preparata.
Preparation method the following steps are included:
S1. microwave radiation exaraction: Chinese medicine being weighed in proportion, cleaning, drying, is crushed, is obtained traditional Chinese medicine powder；By traditional Chinese medicine powder
It is mixed with water according to solid-to-liquid ratio 1: 50, after impregnating 3h, 500r/min stirring, 700W microwave heating is extracted 120min, mentioned to 40 DEG C
Stop heating after taking, cooling, filtering, obtained extracting solution A；
S2. solid-fermented technique: by the solid obtained after the filtering of S1 step it is dry after, the PBS that sprinkling pH is 6.7 is buffered
Liquid, starting moisture 35%, inoculation Lactobacillus casei, enterococcus faecalis and Trametes robiniphila Murr, the inoculum concentration of the Lactobacillus casei are
10%, the inoculum concentration of the enterococcus faecalis is 15%, and the inoculum concentration of the Trametes robiniphila Murr is 20%, ferments after 72h, goes out at 37 DEG C
Living, then by the mass mixings such as solid and water, 700W microwave heating is to 40 DEG C, and after 500r/min stirs 20min, filtering is obtained
Extracting solution B；
S3. the preparation of Chinese medicine: extracting solution A and extracting solution B is mixed, and is concentrated under reduced pressure, and medicinal extract is obtained, and auxiliary material is added and does by spraying
Dry, granulation obtains the Chinese materia medica preparation of prevention and treatment chronic liver disease and jaundice.
Embodiment 3
Raw material forms (parts by weight): 10 parts of tag processed, 10 parts of ginseng tablet, 20 parts of radix paeoniae rubra, 8 parts of rheum officinale, 20 parts of oriental wormwood, Rhizoma Atractylodis Macrocephalae
10 parts, 8 parts of Poria cocos, 3 parts of Radix Glycyrrhizae and 10 parts of radix rehmanniae preparata.
Preparation method the following steps are included:
S1. microwave radiation exaraction: Chinese medicine being weighed in proportion, cleaning, drying, is crushed, is obtained traditional Chinese medicine powder；By traditional Chinese medicine powder
It is mixed with water according to solid-to-liquid ratio 1: 35, after impregnating 2.5h, 400r/min stirring, 600W microwave heating extracts 90min to 37 DEG C,
Stop heating after extraction, cooling, filtering, obtained extracting solution A；
S2. solid-fermented technique: by the solid obtained after the filtering of S1 step it is dry after, the PBS that sprinkling pH is 6.7 is buffered
Liquid, starting moisture 35%, inoculation Lactobacillus casei, enterococcus faecalis and Trametes robiniphila Murr, the inoculum concentration of the Lactobacillus casei are
10%, the inoculum concentration of the enterococcus faecalis is 15%, and the inoculum concentration of the Trametes robiniphila Murr is 20%, ferments after 72h, goes out at 37 DEG C
Living, then by the mass mixings such as solid and water, 600W microwave heating is to 37 DEG C, and after 400r/min stirs 15min, filtering is obtained
Extracting solution B；
S3. the preparation of Chinese medicine: extracting solution A and extracting solution B is mixed, and is concentrated under reduced pressure, and medicinal extract is obtained, and auxiliary material is added and does by spraying
Dry, granulation obtains the Chinese materia medica preparation of prevention and treatment chronic liver disease and jaundice.
1 chronic liver injury of test case to hepatic failure animal model is treated
1.1 SPF grades of material SD rats, totally 65, male, weight 90-120g, purchased from Guangxi Medical University's zoopery
The heart, animal certificate number SCXK (osmanthus) 2009-0002.By animal temperature disposed within (20-25) DEG C, relative humidity before experiment
55%~70% and ventilation environment in, ad lib and drinking-water, adapt to 7 days after carry out modeling experiment.
1.2 experimental method
1.2.1 animal model is constructed
Male SD rat 65 of SPF grades are taken, normal group 5 is randomly divided into, gives and helping after chronic liver failure model group, Cheng Mo
Sun removing toxic substances stagnation resolvation dissipates each 15 of low, middle and high dose groups.In addition to normal group, with 50% carbon tetrachloride vegetable oil solution
(1.5ml/kg) is persistently injected intraperitoneally 4 weeks, after be injected intraperitoneally with 1.6ml/kg to the 6th week and terminate, there is syntexis in rat, spirit is withered
It wastes, ascites determines that chronic liver failure rat model constructs successfully.Intervened 2 weeks after Cheng Mo with the basic, normal, high dosage of Chinese medicine.
1.2.2 intervention stratege
Chinese medicine sets up low dosage 4.725g/kg/d, middle 9.45g/kg/d, high 18.9g/kg/d.Stomach-filling the 5th, 6 week into
Row, continuous gavage 2 weeks, once a day, middle concentration was configured to 9.45g/ml, and each group rat is according to isometric dilution, stomach-filling amount
For 2ml, meanwhile, animal model timeliness is maintained every 3 days intraperitoneal injection carbon tetrachloride vegetable oil solutions.
1.2.3 serum and hepatic tissue Indexs measure
It is seen using glutamic-pyruvic transaminase, glutamic-oxalacetic transaminease, HE dyeing in ELisa enzyme linked immunological double antibody sandwich method measurement serum
Examine hepatic tissue pathology improvement.
1.3 statistical analysis
Statistical data analysis is carried out using 20.0 software package of SPSS.One-way analysis of variance compares multi-group data, data
It is indicated with x_ ± s, two groups of data compare to be examined using T.P < 0.05 is that difference has significant.
2 results
2.1 modeling Success criterias and general behavior observe result
After Cheng Mo control rats appetite stimulator, apathetic, diarrhea, partial rat abdomen expand, weight it is substantially reduced.
Chinese herbs group rat appetite totally improves, and without apparent symptom of diarrhea, rat overall body weight is also obviously increased compared with control group.
The detection of 2.2 serological index
ALT and AST is horizontal in hepatic injury group rat blood serum significantly increases, and has statistical significance with blank group comparing difference
P < 0.05；ALT and AST level decreases after Chinese medicine is treated, and reduction is obvious in middle dose group and high dose group, with
Model group control group comparing difference has statistical significance P < 0.05.Observe that model group is big in hepatic tissue HE dyeing simultaneously
Moderate necrosis is shown in the obvious disorder of mouse lobuli hepatis structure, and liver cell cloudy swelling, the disorder of rat lobuli hepatis structure obtains after Chinese medicine is treated
It is certain to improve, have no obvious liver cell cloudy swelling, degree of necrosis is also improved.It is detailed in Fig. 2-4.
Annotation: ▲ compared with blank group P < 0.05, ● the P < 0.05 compared with model group.
Typical case 1:
Lee, male, 46 years old, Guangxi people from Rong County had slow hepatitis B medical history, after gradually to cirrhosis, long-term sallow complexion,
It dashes forward exacerbation out of strength, mesh eyeball xanthochromia is deepened, and tunnel to hospital is given infrastructural support and treated, and takes 10 parts of tag processed, 10 parts of ginseng tablet, red
20 parts of Chinese herbaceous peony, 8 parts of rheum officinale, 20 parts of oriental wormwood, 10 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Poria cocos, 3 parts of Radix Glycyrrhizae, 10 parts of radix rehmanniae preparata take, from continuously taking 1 after institute
More than month, 1 year follow-up no relapse.
Typical case 2:
Huang, female, 52 years old, people from Nanning had cirrhosis medical history for a long time, and complexion is dull, and sense of dashing forward is out of strength, complexion jaundice,
Receive food still, take 10 parts of tag processed, 10 parts of ginseng tablet, 10 parts of radix paeoniae rubra, 8 parts of rheum officinale, 15 parts of oriental wormwood, 10 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Poria cocos,
3 parts of Radix Glycyrrhizae, 10 parts of radix rehmanniae preparata take, improvement out of strength after a week, complexion xanthochromia subside.
Typical case 3:
Zhang, male, 59 years old, Guangxi Yulin people had liver cancer medical history, and chronic dietary is bad after Liver Cancer Operation, face light yellow complexion, mesh eyeball
Xanthochromia, Chinese materia medica preparation prepared by embodiment 3 are taken, and daily 3 times oral, 3 tablets once, and improvement out of strength after taking 1 week is received and eaten
Turn, even served with after January, mesh eyeball xanthochromia subsides, and spirit is gradually good.
Typical case 4:
Huang, male, 46 years old, Guangxi Bobai people had cirrhosis medical history, unexpected whole body jaundice, mesh eyeball xanthochromia, in hospitalize
Jaundice subsides unobvious after complex treatment, still there is out of strength, the micro- Huang of whole body after discharge, and Chinese materia medica preparation prepared by embodiment 3 is taken, often
Day is 3 times oral, and 3 tablets once, continuously takes 2 weeks, and spirit improves, and jaundice subsides substantially.
Compared with prior art, the main object of the present invention is that the clinic of the current chronic liver disease burst jaundice illness of improvement is controlled
Predicament is treated, with strengthening YANG and invigorating YIN, detoxification and removing stasis, the raw new response to treatment of kidney tonifying, liver regeneration microenvironment can be improved to accelerate jaundice
Recession, curative effect are with the obvious advantage, cheap.
Those skilled in the art is not under conditions of departing from the spirit and scope of the present invention that claims determine, also
Various modifications can be carried out to the above content.Therefore the scope of the present invention is not limited in above explanation, but by
The range of claims determines.
Claims (10)
1. the Chinese medicine composition of a kind of prevention and treatment chronic liver disease and jaundice, which is characterized in that including following raw material: tag processed, people
Join piece, radix paeoniae rubra, rheum officinale, oriental wormwood, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix rehmanniae preparata and Radix Glycyrrhizae.
2. a kind of prevention and treatment chronic liver disease and the Chinese medicine composition of jaundice according to claim 1, which is characterized in that by following
Raw material is formed according to parts by weight: tag 10-20 parts processed, 10-20 parts of ginseng tablet, 15-30 parts of radix paeoniae rubra, 10-15 parts of rheum officinale, oriental wormwood
15-30 parts, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 8-10 parts of Poria cocos, 3-8 parts of Radix Glycyrrhizae and 10-15 parts of radix rehmanniae preparata.
3. a kind of prevention and treatment chronic liver disease and the Chinese medicine composition of jaundice according to claim 2, which is characterized in that by following
Raw material is formed according to parts by weight: 10 parts of tag processed, 10 parts of ginseng tablet, 20 parts of radix paeoniae rubra, 8 parts of rheum officinale, 20 parts of oriental wormwood, 10 parts of Rhizoma Atractylodis Macrocephalae,
8 parts of Poria cocos, 3 parts of Radix Glycyrrhizae and 10 parts of radix rehmanniae preparata.
4. the preparation method of a kind of prevention and treatment chronic liver disease and the Chinese materia medica preparation of jaundice, which is characterized in that raw material such as claim
Described in any one of 1-3 claim, preparation method the following steps are included:
S1. microwave radiation exaraction: Chinese medicine being weighed in proportion, cleaning, drying, is crushed, is obtained traditional Chinese medicine powder；By traditional Chinese medicine powder and water
According to solid-to-liquid ratio 1: (20-50) mixing, after impregnating 2-3h, microwave heating while stirring is extracted 60-120min, is mentioned to 35-40 DEG C
Stop heating after taking, cooling, filtering, obtained extracting solution A；
S2. solid-fermented technique: by the solid obtained after the filtering of S1 step it is dry after, the PBS buffer solution that sprinkling pH is 6.7,
Starting moisture is 35%, inoculation Lactobacillus casei, enterococcus faecalis and Trametes robiniphila Murr, is fermented after 72h at 37 DEG C, then inactivation will consolidate
The mass mixings such as body and water, after microwave heating to 35-40 DEG C of stirring 10-20min, filtering, obtained extracting solution B；
S3. the preparation of Chinese medicine: extracting solution A and extracting solution B is mixed, and is concentrated under reduced pressure, and medicinal extract is obtained, and auxiliary material spray drying is added,
Granulation obtains the Chinese materia medica preparation of prevention and treatment chronic liver disease and jaundice.
5. the preparation method according to claim 4, which is characterized in that the speed of agitator is 300-500r/min.
6. the preparation method according to claim 4, which is characterized in that the inoculum concentration of the Lactobacillus casei is 10%, institute
The inoculum concentration for stating enterococcus faecalis is 15%, and the inoculum concentration of the Trametes robiniphila Murr is 20%.
7. the preparation method according to claim 4, which is characterized in that the power of the microwave heating is 500-700W.
8. prevention and treatment chronic liver disease and jaundice made from a kind of preparation method as described in any one of claim 4-7 claim
Chinese materia medica preparation.
9. a kind of Chinese materia medica preparation as described in any one of claim 1-3 claim is in prevention and treatment chronic liver disease and the drug of jaundice
In application.
10. a kind of application of Chinese medical extract as claimed in claim 8 in prevention and treatment chronic liver disease and the drug of jaundice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910727920.6A CN110269896A (en) | 2019-08-07 | 2019-08-07 | A kind of Chinese medicine composition for preventing and treating chronic liver disease and jaundice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910727920.6A CN110269896A (en) | 2019-08-07 | 2019-08-07 | A kind of Chinese medicine composition for preventing and treating chronic liver disease and jaundice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110269896A true CN110269896A (en) | 2019-09-24 |
Family
ID=67965910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910727920.6A Withdrawn CN110269896A (en) | 2019-08-07 | 2019-08-07 | A kind of Chinese medicine composition for preventing and treating chronic liver disease and jaundice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110269896A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116036217A (en) * | 2022-12-23 | 2023-05-02 | 广西中医药大学第一附属医院 | Traditional Chinese medicine compound granule for treating primary liver cancer and preparation method thereof |
-
2019
- 2019-08-07 CN CN201910727920.6A patent/CN110269896A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116036217A (en) * | 2022-12-23 | 2023-05-02 | 广西中医药大学第一附属医院 | Traditional Chinese medicine compound granule for treating primary liver cancer and preparation method thereof |
| CN116036217B (en) * | 2022-12-23 | 2023-11-21 | 广西中医药大学第一附属医院 | Traditional Chinese medicine compound granule for treating primary liver cancer and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101112547A (en) | Chinese traditional medicine preparations for treating postpartum spontaneous sweating | |
| CN103316249B (en) | Astragalus taxus chinensis capsule and preparing process thereof | |
| CN101259224A (en) | Chinese medicine preparation for treating spontaneous perspiration and night sweating | |
| CN103536881A (en) | Drug for treating chronic gastritis | |
| CN110269896A (en) | A kind of Chinese medicine composition for preventing and treating chronic liver disease and jaundice | |
| CN105381424A (en) | Traditional Chinese medicine for detoxifying human viscera and preparation method of traditional Chinese medicine | |
| CN101129841A (en) | Traditional Chinese medicine composition for treating self-output of latex | |
| CN104705720B (en) | A kind of functional drinks regulating female incretion | |
| CN103239692B (en) | Chinese medicine liniment for treating skin itch and preparation method of Chinese medicine liniment | |
| CN102008634A (en) | Chinese medicinal health-care tea for preventing and treating diabetes | |
| CN101085259A (en) | Traditional Chinese medicine decoction for treating chronic nephritis | |
| CN105311556A (en) | Traditional Chinese medicine granules for treating jaundice hepatitis and preparation method thereof | |
| CN110123983A (en) | Chinese medicine composition and its preparation method and application for improving skin | |
| CN104189661A (en) | Traditional Chinese medicine for treating fibromyalgia syndrome | |
| CN102406913A (en) | Chinese medicinal composition for treating melancholia | |
| CN103007202A (en) | Traditional Chinese medicine composition for treating pancreatic cancer | |
| CN103432544B (en) | Decoction for treating upper gastrointestinal hemorrhage | |
| CN107496754A (en) | A kind of oral liquid for treating canker sore | |
| CN106668772A (en) | Decoction medicine for treating heart-fire and liver-fire hyperactivity type insomnia and preparation method of decoction medicine | |
| CN102049030B (en) | Chinese medicinal composition for treating gastrointestinal pain | |
| CN101361959B (en) | Medicine for curing the dysmenorrhea | |
| CN100553661C (en) | A kind of medicine for the treatment of thromboangiitis obliterans of lower limb and preparation method thereof | |
| CN105687897A (en) | Pure traditional Chinese medicine preparation for treating diabetes and preparation method of pure traditional Chinese medicine preparation for treating diabetes | |
| CN105457004A (en) | Orally-taken medicine for treating stomachaches caused by deficient cold of spleens and stomachs and preparation method thereof | |
| CN103735807B (en) | A kind of medicine for the treatment of prurigo and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190924 |