CN110269637A - Meet processing unit, method and PET system - Google Patents
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- 238000012545 processing Methods 0.000 title claims abstract description 88
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- 239000011159 matrix material Substances 0.000 claims description 9
- 238000003672 processing method Methods 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 abstract description 9
- 238000012636 positron electron tomography Methods 0.000 description 107
- 238000010586 diagram Methods 0.000 description 12
- 230000004044 response Effects 0.000 description 8
- 238000012831 peritoneal equilibrium test Methods 0.000 description 5
- 238000012877 positron emission topography Methods 0.000 description 5
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- 238000001727 in vivo Methods 0.000 description 2
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- 238000012879 PET imaging Methods 0.000 description 1
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- 238000002600 positron emission tomography Methods 0.000 description 1
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Abstract
The present invention relates to one kind to meet processing unit, method and PET system.The processing unit that meets includes: multiple to meet module and multiple PET units；Wherein, at least one meets module and carries out meeting processing to the detector output data of at least one PET unit, output is local to meet data, and, meet module described at least one and meets module acquisition detector output data from other, intersect with the detector output data for meeting module described at least one and meet processing, output cross meets data.It is above-mentioned to meet processing unit, method and PET system, it is arranged and multiple meets module, meet module output and locally meets data, and, the detector output data for meeting module and obtaining other PET units, intersect with the detector output data of this PET unit and meets processing, and output cross meets data, the coincidence detections of multiple PET single-element detectors can be completed at the same time and meet processing with intersecting, substantially increase the sensitivity and efficiency of PET system.
Description
Technical field
The present invention relates to the field of medical instrument technology, meet processing unit, method and PET system more particularly to one kind.
Background technique
Positron emission computed tomography (Positron Emission Tomography, PET) is a kind of utilization
Inside to organism inject positron radioactivity isotope labelling compound, and measure in vitro they spatial distribution and when
Between characteristic three-dimensional imaging non-destructive testing technology, have the characteristics that high sensitivity, accuracy be good, accurate positioning.
The working principle of PET are as follows: by the radioisotope labeling for emitting positive electron to can participate in tissue blood flow or
On the compound of metabolic process, the radionuclide for indicating positively charged sub- compound is injected into subject's body, allows subject
PET imaging is carried out within the scope of the effective field of view of PET.During PET scan, the positive electron that active nucleus is launched is in vivo
Annihilation radiation (i.e. annihilation event) occurs in conjunction with the negative electron in tissue after mobile about 1mm, it is equal, square to generate two energy
To opposite γ photon.Since two γ photons distance in vivo is different, reach two detectors time also have it is certain poor
Not, if in defined time window (such as 0-15us), the probe system in line of response detects two and is mutually 180 degree
When the photon of (± 0.25 degree), constitutes one and meet event, processing equipment will record the data of response, and initial data passes through
Image Reconstruction Technology, image required for can get.
The processing unit that meets of PET system can be realized two energy equal (511keV), contrary γ photon
Meet detection, meet processing unit meets detection processing capacity, directly determines the coincidence counting rate and system spirit of PET system
Sensitivity.
There is usually one PET unit, inside to be made of multiple detectors for traditional PET device, and traditional meets processing
Device, which can only be handled, sentences choosing meeting between each detector data inside a unit, when there is multiple PET units, is unable to complete more
The coincidence detection of a PET single-element detector meets processing with intersecting, and causes system sensitivity poor, efficiency is lower.
Summary of the invention
Based on this, it is necessary to for traditional synchronous symbol for meeting processing unit and being unable to complete multiple PET single-element detectors
It closes and meets processing with intersecting, cause system sensitivity poor, the lower problem of efficiency provides one kind and meets processing unit, method
And PET system.
One kind meeting processing unit, and in the PET system for more PET units, the processing unit that meets includes:
Multiple to meet module and multiple PET units, multiple modules that meet are for obtaining the spy in multiple PET units
It surveys device output data and carries out meeting processing, output meets data；
Wherein, at least one meets module and carries out meeting processing to the detector output data of at least one PET unit, defeated
It is local out to meet data, also, meet module described at least one and meet module from other and obtain detector output data, and extremely
The detector output data for meeting module described in one few, which intersect, meets processing, and output cross meets data.
The processing unit that meets further includes rebuilding module in one of the embodiments, the reconstruction module with it is multiple
The module that meets is connected, and described meet data for receiving and carries out image reconstruction.
The processing unit that meets further includes control forwarding module in one of the embodiments, and the control forwards mould
Block be connected to it is described meet between module and the reconstructions module, for meeting data described in receiving and being transmitted to the reconstruction mould
Block.
It is described in one of the embodiments, that meet processing unit further include control module, the control module with it is described
It controls forwarding module to be connected, for sending forwarding instruction to the control forwarding module.
The module that meets includes locally meeting unit and intersecting to meet unit in one of the embodiments, described
Locally meet unit to be used to that the detector output data of corresponding PET unit to be carried out meeting processing, obtain locally meeting data,
Multiple intersections meet detector output data of the unit for the PET unit to corresponding PET unit and other non-corresponding
Intersect and meet processing, obtains intersecting and meet data, it is described to meet that the local is met data by module and intersection meets number
According to output to the reconstruction module.
The reconstruction module includes image reconstruction machine in one of the embodiments,.
It is described in one of the embodiments, that meet processing unit further include memory module, the memory module with it is multiple
The module that meets is connected, and the memory module multiple described meet the detector output data of module and deposit for receiving
Storage, it is described to meet module and obtain other detector output datas for meeting module from the memory module.
The memory module includes meeting module interconnection matrix in one of the embodiments,.
One kind meeting processing method, meets processing unit applied to above-mentioned, the processing method that meets includes:
Receive the detector output data of PET unit；
It carries out meeting processing based at least one detector output data for meeting the corresponding PET unit of module, output is originally
Ground meets data；
Detector output data based at least one PET unit for meeting the corresponding PET unit of module and non-corresponding into
Row intersects and meets processing, and output cross meets data.
A kind of PET system, including above-mentioned meet processing unit, PET rack, hospital bed and console computer；
Wherein, multiple PET units are successively arranged along the axial direction of the PET rack, and each PET unit is by multiple
PET crystal detection unit composition, the PET crystal detection unit surround the PET unit.
Above-mentioned to meet processing unit, method and PET system, setting is multiple to meet module, meets module to this PET unit
Detector output data carries out meeting processing, and output is local to meet data, also, the module that meets obtains other PET units
Detector output data, intersect with the detector output data of this PET unit and meet processing, output cross meets number
According to can be completed at the same time the coincidence detections of multiple PET single-element detectors with intersecting and meet processing, substantially increase PET system
Sensitivity and efficiency.
Detailed description of the invention
The schematic diagram of Fig. 1 line of response between single PET unit inner detector；
Fig. 2 is the schematic diagram of line of response between detector in the PET system of multiple PET units；
Fig. 3 is the schematic diagram for meeting processing unit of one embodiment of the invention；
Fig. 4 is the schematic diagram for meeting processing unit of another embodiment of the present invention；
Fig. 5 is the schematic diagram for meeting module of one embodiment of the invention；
Fig. 6 is the schematic diagram for meeting processing method of one embodiment of the invention.
Specific embodiment
It is with reference to the accompanying drawings and embodiments, right in order to which the objects, technical solutions and advantages of the application are more clearly understood
The application is further elaborated.It should be appreciated that specific embodiment described herein is only used to explain the application, not
For limiting the application.
There is usually one PET unit, inside to be made of multiple detectors for traditional PET device, and traditional meets processing
Device, which can only be handled, sentences choosing meeting between each detector data inside a unit.
Referring to Fig. 1, the schematic diagram of Fig. 1 line of response between single PET unit inner detector.
As shown in Figure 1, a pair of of detector generation in a PET unit meets line of response, such design can only be applied
In the lesser system design of axial range, scanning needs multiple bed acquisitions every time, and total acquisition time is longer.
From the aspect of reliability and maintainability, it is limited to the limitation of the strength of materials and technique, makes axial length
Biggish PET unit is more difficult, so requiring biggish PET system for the axial visual field, it is necessary to be divided into multiple PET units and set
It counts and carries out the intersection across unit and meet.
Referring to Fig. 2, Fig. 2 is the schematic diagram of line of response between detector in the PET system of multiple PET units.
As shown in Fig. 2, across the unit generation symbol of detector between the detector and PET unit UNIT3 of PET unit UNIT0
Close line of response.
Illustratively, it is formed in parallel PET cell array PET system in eight PET units, needs to meet processing unit and exist
While completing detector data acquisition in unit, it can complete to meet processing and completion across unit inside this PET unit
Intersection meet processing, while ensuring the detector energy accurate synchronization on all PET units.
Referring to Fig. 3, Fig. 3 is the schematic diagram for meeting processing unit of one embodiment of the invention.
In the present embodiment, it is described meet processing unit include it is multiple meet module 10 and multiple PET units 11, it is multiple
Meet module 10 for obtaining the detector output data in multiple PET units 11 and carrying out meeting processing, output meets
Data.Meet module 10 and the quantity of the PET unit 11 determines according to the actual situation it should be understood that described.
Wherein, at least one meets module 10 and carries out meeting place to the detector output data of at least one PET unit 11
Reason, output is local to meet data, also, meets module 10 described at least one and meet the acquisition detector output of module 10 from other
Data, intersect with the detector output data for meeting module 10 described at least one and meet processing, and output cross meets number
According to.It is determined according to the actual situation it should be understood that meeting the combinations of pairs mode that the intersection between module meets.
It is above-mentioned meet processing unit setting it is multiple meet module 10, the detector for meeting 10 pairs of this PET units 11 of module is defeated
Data carry out meeting processing out, and output is local to meet data, also, the spy for meeting module 10 and obtaining other PET units 11
Device output data to be surveyed, intersect with the detector output data of this PET unit 11 and meets processing, output cross meets data,
The coincidence detections of multiple 11 detectors of PET unit can be completed at the same time and meet processing with intersecting, substantially increase the spirit of PET system
Sensitivity and efficiency.
Referring to Fig. 4, Fig. 4 is the schematic diagram for meeting processing unit of another embodiment of the present invention.
In the present embodiment, the processing unit that meets further includes rebuilding module 12, the reconstruction module 12 and multiple institutes
It states and meets module 10 and be connected, described meet data for receiving and carry out image reconstruction.It should be understood that the reconstruction module 12
Quantity determine according to the actual situation.
Specifically, the reconstruction module 12 includes image reconstruction machine.
Illustratively, the processing unit that meets further includes control forwarding module 13, and the control forwarding module 13 connects
Meet between module 10 and the reconstruction module 12 in described, described meet data for receiving and be transmitted to the reconstruction module
12。
It should be understood that the processing unit that meets further includes control module 14, the control module 14 and the control
Forwarding module 13 is connected, for sending forwarding instruction to the control forwarding module 13.
Illustratively, the processing unit that meets further includes memory module 15, the memory module 15 and multiple symbols
It molds block 10 to be connected, the memory module 15 multiple described meet the detector output data of module 10 and deposit for receiving
Storage, it is described to meet module 10 and obtain other detector output datas for meeting module 10 from the memory module 15.
It should be understood that the memory module 15 includes meeting 10 interconnection matrix of module.Specifically, described to meet module 10
Interconnection matrix is connected with multiple modules 10 that meet, and multiple modules 10 that meet meet the interconnection square of module 10 described in
Battle array exchanging detector output data.
Referring to Fig. 5, Fig. 5 is the schematic diagram for meeting module of one embodiment of the invention.
In the present embodiment, the module 10 that meets includes locally meeting unit 101 and intersecting to meet unit 102, institute
The local unit 101 that meets is stated for carrying out meeting processing to the detector output data of corresponding PET unit 11, obtains local symbol
Data are closed, multiple intersections meet unit 102 for the PET unit 11 to corresponding PET unit 11 and other non-corresponding
Detector output data, which intersect, meets processing, obtains intersection and meets data, the module 10 that meets meets the local
Data and intersection meet data and export to the reconstruction module 12.It should be understood that the module 10 that meets includes a local
Meet unit 101 and multiple intersections meet unit 102.
Illustratively, the module 10 that meets further includes input storage unit, the input storage unit and the local
Meet unit 101 and intersection meets unit 102 and is connected, for receiving the detector data of this PET unit 11 and being sent to described
Locally meet that unit 101, intersection meets unit 102 and other meet module 10.It should be understood that the module 10 that meets includes
Two input storage units, the first input-buffer unit 103 are used to receive the detector data of this PET unit 11 and are sent to institute
It states locally to meet unit 101 and intersect and meets unit 102, the second input-buffer unit 104 is used to receive the spy of this PET unit 11
Survey device data and replicate more parts, be sent to it is other meet module 10, specifically, the second input-buffer unit 104 is for connecing
It receives the detector data of this PET unit 11 and replicates more parts, be sent to and described meet 10 interconnection matrix of module.
Illustratively, the module 10 that meets further includes output cache unit 105, the output cache unit 105 and institute
State it is local meet unit 101 and intersect meet unit 102 and be connected, the local that unit 101 is met for receiving the local meets
The intersection that data and intersection meet unit 102 meets data, and the local met data and intersects that meet data defeated
Out to the reconstruction module 12.
Specifically, meet in unit 101 locally, the detector output data of corresponding PET unit 11 matches two-by-two, arbitrarily
A pair of of detector output data, which has to export when the data met in window width, meets data, meets in unit in intersection, corresponding PET
The detector output data of unit and the detector output data of non-corresponding PET unit match two-by-two, and any pair of detector is defeated
Data, which have to export when the data met in window width, out meets data.
It should be understood that after receiving system synchronization instruction, it can remove and each meet all cachings of inside modules, institute
There is the caching in detector, and this unit is met into the stateful resetting of institute in module, by the coincidence counter of all detectors
It resets, after system synchronizes, restarts data acquisition and meet judgement, it is ensured that system accurate synchronization.
Table 1 is please referred to, table 1 is that the intersection of one embodiment of the invention meets interconnection matrix.
The intersection of table 1 meets interconnection matrix
| Input from | Output to | coincidence | |
| Unit 0 | 2,3,4 | 1, | 0-0,0-2,0-3,0-4 |
| Unit 1 | 0,3,4 | 2,5 | 1-1,1-0,1-3,1-4 |
| Unit 2 | 1,4,6 | 0,3,5 | 2-2,2-1,2-4,2-6 |
| Unit 3 | 2,6,7 | 0,1,4,5 | 3-3,3-2,3-6,3-7 |
| Unit 4 | 3,5,6 | 0,1,2,7 | 4-4,4-5,4-3,4-6 |
| Unit 5 | 1,2,3 | 4,6,7 | 5-5,3-5,2-5,1-5 |
| Unit 6 | 5,7 | 2,3,4 | 6-6,5-6,6-7, |
| Unit 7 | 4,5 | 3,6 | 7-7,4-7,5-7 |
Illustratively, by taking the Unit0 in table 1 as an example, the module reception that meets of Unit0 meets in module interconnection matrix
The detector output data of Unit2, Unit3, Unit4, while sending detector output data to and meeting module interconnection matrix
Interior Unit1's meets in module, and such Unit0's meets module and can export the local of Unit0 and meet data and Unit0-
The intersection of tri- groups of PET unit combinations of pairs of Unit2, Unit0-Unit3, Unit0-Unit4 meets data.It is also possible to obtain
The combinations of pairs mode of other Unit.
Referring to Fig. 6, Fig. 6 is the schematic diagram for meeting processing method of one embodiment of the invention.
In the present embodiment, the processing method that meets includes:
Step 600, the detector output data of PET unit is received.
It should be understood that the detector output data for receiving PET unit includes the detection for receiving corresponding PET unit
The detector output data of the PET unit of device output data and non-corresponding.
Step 610, it carries out meeting place based at least one detector output data for meeting the corresponding PET unit of module
Reason, output is local to meet data.
Step 620, the detector based at least one PET unit for meeting the corresponding PET unit of module and non-corresponding is defeated
Data, which intersect, out meets processing, and output cross meets data.
The invention also discloses a kind of PET system, the PET system includes above-mentioned meeting processing unit, PET rack, disease
Bed and console computer.Specifically, the processing unit that meets is connected with the PET rack, and the PET rack is around described
Hospital bed, the console computer are connected with the PET rack.
Illustratively, multiple PET units are successively arranged along the axial direction of the PET rack, each PET unit by
Multiple PET crystal detection unit compositions, the PET crystal detection unit surround the PET unit.
Above-mentioned to meet processing unit, method and PET system, setting is multiple to meet module, meets module to this PET unit
Detector output data carries out meeting processing, and output is local to meet data, also, the module that meets obtains other PET units
Detector output data, intersect with the detector output data of this PET unit and meet processing, output cross meets number
According to can be completed at the same time the coincidence detections of multiple PET single-element detectors with intersecting and meet processing, substantially increase PET system
Sensitivity and efficiency.Meanwhile the more traditional PET device of LOR number that can handle of framework of the invention has about 52 times of promotion, makes
PET device sensitivity has nearly 40 times of promotion, meanwhile, this framework has good scalability, not for PET number of unit
Together, intersect and meet pairing difference, detector number is different in a unit, can there is different configurations.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. one kind meets processing unit, in the PET system for more PET units, which is characterized in that described to meet processing unit packet
It includes:
Multiple to meet module and multiple PET units, multiple modules that meet are for obtaining the detector in multiple PET units
Output data simultaneously carries out meeting processing, and output meets data；
Wherein, at least one meets module and carries out meeting processing to the detector output data of at least one PET unit, and output is originally
Ground meets data, also, meets module described at least one and meet module acquisition detector output data from other, at least one
A detector output data for meeting module, which intersect, meets processing, and output cross meets data.
2. according to claim 1 meet processing unit, which is characterized in that the processing unit that meets further includes rebuilding mould
Block, the reconstruction module are connected with multiple modules that meet, and described meet data for receiving and carry out image reconstruction.
3. according to claim 2 meet processing unit, which is characterized in that the processing unit that meets further includes that control turns
Send out module, the control forwarding module be connected to it is described meet between module and the reconstruction module, for meeting described in receiving
Data are simultaneously transmitted to the reconstruction module.
4. according to claim 3 meet processing unit, which is characterized in that the processing unit that meets further includes control mould
Block, the control module are connected with the control forwarding module, for sending forwarding instruction to the control forwarding module.
5. according to claim 2 meet processing unit, which is characterized in that the module that meets includes locally meeting unit
And intersect and meet unit, the local meets unit for meeting the detector output data of corresponding PET unit
Processing, obtain it is local meet data, multiple intersections meet unit for corresponding PET unit and other non-corresponding
The detector output data of PET unit, which intersect, meets processing, obtains intersection and meets data, the module that meets is by described
Ground meets data and intersection meets data and exports to the reconstruction module.
6. according to claim 2 meet processing unit, which is characterized in that the reconstruction module includes image reconstruction machine.
7. according to claim 1 meet processing unit, which is characterized in that the processing unit that meets further includes storage mould
Block, the memory module with it is multiple it is described meet module and be connected, the memory module multiple described meets module for receiving
Detector output data and storage, it is described meet module from the memory module obtain it is other meet module detectors output
Data.
8. according to claim 7 meet processing unit, which is characterized in that the memory module includes meeting module interconnection
Matrix.
9. one kind meets processing method, meet processing unit applied to claim 1-8 is described in any item, which is characterized in that
The processing method that meets includes:
Receive the detector output data of PET unit；
It carries out meeting processing based at least one detector output data for meeting the corresponding PET unit of module, exports local symbol
Close data；
Detector output data based at least one PET unit for meeting the corresponding PET unit of module and non-corresponding is handed over
Fork meets processing, and output cross meets data.
10. a kind of PET system, including claim 1-8 is described in any item meets processing unit, PET rack, hospital bed and control
Platform computer；
Wherein, multiple PET units are successively arranged along the axial direction of the PET rack, and each PET unit is by multiple PET
Crystal detection unit composition, the PET crystal detection unit surround the PET unit.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910511146.5A CN110269637A (en) | 2019-06-13 | 2019-06-13 | Meet processing unit, method and PET system |
| EP20791156.1A EP3937785A4 (en) | 2019-04-15 | 2020-04-15 | Systems and methods for determining true coincidence events |
| PCT/CN2020/084861 WO2020211764A1 (en) | 2019-04-15 | 2020-04-15 | Systems and methods for determining true coincidence events |
| US17/450,837 US20220031272A1 (en) | 2019-04-15 | 2021-10-14 | Systems and methods for determining true coincidence events |
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| CN201910511146.5A CN110269637A (en) | 2019-06-13 | 2019-06-13 | Meet processing unit, method and PET system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111728633A (en) * | 2020-08-11 | 2020-10-02 | 上海联影医疗科技有限公司 | PET system cross coincidence data processing method and device and computer equipment |
| WO2020211764A1 (en) * | 2019-04-15 | 2020-10-22 | Shanghai United Imaging Healthcare Co., Ltd. | Systems and methods for determining true coincidence events |
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