CN106691486A

CN106691486A - Medical imaging system and method

Info

Publication number: CN106691486A
Application number: CN201611258740.0A
Authority: CN
Inventors: 李弘棣; 刘伟平; 顾笑悦
Original assignee: Shanghai United Imaging Healthcare Co Ltd
Current assignee: Shanghai United Imaging Healthcare Co Ltd
Priority date: 2016-12-30
Filing date: 2016-12-30
Publication date: 2017-05-24

Abstract

The invention discloses a medical imaging system and method. The system comprises an imaging scanning device and computer equipment, wherein the device comprises a first PET scanning unit, a second PET scanning unit and a driving device; the computer equipment comprises a controller and a processor; a first scanning position and a second scanning position can be determined by the controller; the driving device can drive the first PET scanning unit and the second PET scanning unit to respectively move to the first scanning position and the second scanning position; the first PET scanning unit and the second PET scanning unit respectively acquire first scanning data and second scanning data; and the processor can be based on the first scanning data and the second scanning data, and images a first scanning region corresponding to the first scanning position and a second scanning region corresponding to the second scanning position.

Description

Medical image system and method

Technical field

The present invention relates to a kind of medical image system and method, dynamic is adopted simultaneously can to carry out multiple organ more particularly, to one kind Positron emission tomography (Positron Emission Tomography, PET) system and method for collection.

Background technology

In medical scanning imaging, PET scan can be imaged to the metabolic condition of partes corporis humani's bit organization, particularly suitable In the diagnosis and the assessment of therapeutic effect that tumour, coronary heart disease, brain diseases etc. carried out with early stage.Dynamic acquisition imaging can be provided Human organ is metabolized the information that changes with time, but the axial scan field range of PET scan unit commercial at present is small, typically It is 16-22cm, it is impossible to which multiple organs are carried out with dynamic imaging simultaneously, therefore exists in the metabolic condition of the multiple organs of contrast tired It is difficult.

If be imaged to multiple organs respectively using PET scan unit, the decay of contrast agent will make Different Organs Imaging results do not possess comparativity.The contrast agent shorter for half-life period, its influence will be bigger.And an axial scan visual field model The manufacturing cost for enclosing larger PET scan unit is very high.Accordingly, it would be desirable to one kind can meet multiple organ, and dynamic is adopted simultaneously Collection, and with the PET designs compared with high performance-price ratio.

The content of the invention

It is an object of the invention to provide a kind of medical image system and method, multiple organ dynamic acquisition need simultaneously can be met Ask.

To achieve the above object, the invention provides a kind medical image system, the system includes imaging scanner And computer equipment；The imaging scanner includes the first PET scan unit, the second PET scan unit and drive device；Institute Stating computer equipment includes controller and processor, and the controller can determine that the first scan position and the second scan position；Its In, the drive device can drive the first PET scan unit and the second PET scan unit to be respectively moved to described first and sweep Position and the second scan position are retouched, the first PET scan unit and the second PET scan unit can respectively obtain one first and sweep Data and second scan data are retouched, and the processor can be based on first scan data and the second scan data, Corresponding first scanning area of first scan position and corresponding second scanning area of second scan position are carried out Imaging.

In one embodiment of the invention, the first PET scan unit includes a first pet detector ring, The second PET scan unit includes a second pet detector ring, the first pet detector ring and the second pet detector Ring is compared to identical or different diameter.

In one embodiment of the invention, the first PET scan unit and the second PET scan unit are arranged on institute State in drive device, the drive device can drive the first PET scan unit and the second PET scan unit to move vertically It is dynamic.

In one embodiment of the invention, a CT scan unit is further included, the CT scan unit is obtained CT scan data, based on the CT scan data, the processor generates a positioning image.

In one embodiment of the invention, the positioning image includes one first mark and one second mark, The controller determines first scan position and the second scanning by obtaining first mark and the second position for identifying Position.

In one embodiment of the invention, the controller can be swept by obtaining first scan position and second Position is retouched, it is determined that driving the distance of the first PET scan unit and the movement of the second PET scan unit.

In one embodiment of the invention, an imageing sensor is further included, described image sensor is produced View data, the controller is based on described image data, determines first scan position and second scan position.

In one embodiment of the invention, the first PET scan unit and the second PET scan unit can be obtained respectively First scan data and the second scan data at multiple moment are taken, the processor can be based on first scanning at the multiple moment Data and the second scan data, dynamic imaging is carried out to first scanning area and the second scanning area.

In one embodiment of the invention, the processor can be based on the dynamic imaging, determine that described first sweeps The metabolism of contrast agent in region and the second scanning area is retouched, the metabolism is changed over time.

In one embodiment of the invention, the processor can be swept based on first scan data and described second Data are retouched while being imaged to first scanning area and the second scanning area.

In one embodiment of the invention, the processor can be based on the first PET scan unit and the 2nd PET The 3rd scan data that scanning element is obtained is imaged to the 3rd scanning area, and the 3rd scan data is by described the One PET scan unit and the second PET scan unit are obtained jointly, the 3rd scanning area between first scanning area and Between second scanning area.

In one embodiment of the invention, the processor can be based on the first PET scan unit and the 2nd PET The scan data that scanning element is obtained is carried out into respectively to first scanning area, the second scanning area and the 3rd scanning area Picture, and be a complete image by the image mosaic of acquisition.

In one embodiment of the invention, the first PET scan unit obtains the first sweep parameter, according to acquisition First sweep parameter, scan first scanning area；And the second PET scan unit obtains the second scanning ginseng Number, according to second sweep parameter for obtaining, scans second scanning area, wherein, first sweep parameter and institute State the second sweep parameter similar and different.

In one embodiment of the invention, the processor obtains the first imaging parameters, according to the first the one-tenth obtained As parameter, first scanning area is imaged；And the processor obtains the second imaging parameters, according to described for obtaining Two imaging parameters, are imaged to second scanning area, wherein, first imaging parameters and the second imaging parameters are different or phase Together.

In one embodiment of the invention, the axially or radially scan vision of the second PET scan unit and institute The axially or radially scan vision for stating the first PET scan unit is similar and different.

To achieve the above object, present invention also offers a kind of medical imaging procedure, including：Obtain and swept for a PET Retouch the first PET scan parameter and the second PET scan parameter for the second PET scan unit of unit；Obtain first and scan position Put and the second scan position；According to the first PET scan parameter, using the first PET scan unit to the described first scanning position Put corresponding first scanning area to be scanned, generate the first PET scan data；According to the second PET scan parameter, use Second PET scan unit is scanned to corresponding second scanning area of second scan position, generates the second PET scan number According to；First scanning area is imaged based on first PET scan data；And based on second PET scan Data are imaged to second scanning area.

Brief description of the drawings

Fig. 1 is the schematic diagram based on example imaging system in the application some embodiments.

Fig. 2A is the schematic diagram based on example imaging scanner in the application some embodiments.

Fig. 2 B are the schematic diagrames based on example computer in the application some embodiments.

Fig. 3 is the schematic diagram based on example imaging system in the application some embodiments.

Fig. 4 is the flow chart based on the illustrative methods that scan image is generated in the application some embodiments.

Fig. 5 is based on a schematic diagram for exemplary scan module in the application some embodiments.

Fig. 6 is the flow chart based on the illustrative methods that PET scan parameter is set in the application some embodiments.

Fig. 7 is based on a schematic diagram for sample scan module in the application some embodiments.

Fig. 8 is the schematic diagram based on the illustrative methods that PET scan data is obtained in the application some embodiments.

Fig. 9 is the schematic diagram of the illustrative methods based on the PET scan data that acquisition is processed in the application some embodiments.

Figure 10 is based on a schematic diagram for sample scan module in the application some embodiments.

Figure 11 is based on a schematic diagram for sample scan module in the application some embodiments.

Figure 12 is based on a schematic diagram for sample scan module in the application some embodiments.

Figure 13 is based on a schematic diagram for sample scan module in the application some embodiments.

Specific embodiment

It is understandable to enable the above objects, features and advantages of the present invention to become apparent, below in conjunction with the accompanying drawings to the present invention Specific embodiment be described in detail.

Chu ground explanation embodiments herein technical scheme, embodiment will be described below needed for the accompanying drawing to be used It is briefly described.It should be evident that drawings in the following description are only some examples or embodiment of the application, for this For the those of ordinary skill in field, on the premise of not paying creative work, can also be according to these accompanying drawings by the application It is applied to other similar scenes.Unless obviously or separately explained from language environment, identical label represents identical knot in figure Structure or operation.

As shown in the specification and claims, unless context clearly points out exceptional situation, " one ", " one ", The word such as " one kind " and/or " being somebody's turn to do " not refers in particular to odd number, may also comprise plural number.It is, in general, that term " including " only carried with "comprising" Show including clearly identify the step of and element, and these steps and element do not constitute one it is exclusive enumerate, method or Equipment is likely to comprising the step of other or element.Term "based" is " being based at least partially on ".Term " one embodiment " Represent " at least one embodiment "；Term " another embodiment " expression " at least one further embodiment ".The phase of other terms Close during definition will be described below and be given.

Although the application is made that various references to some of the system according to embodiments herein module, however, Any amount of disparate modules can by using and run on electric control gear.These modules are merely illustrative, and this is The different aspect of system and method can use disparate modules.

Fig. 1 is based on example imaging system schematic diagram in the application some embodiments.Imaging system 100 can be to a mesh Mark object is scanned, and generates associated picture based on scan data.In certain embodiments, imaging system 100 can be one Individual medical image system.Imaging system 100 can include an imaging scanner 110 and a computer equipment 120.Imaging Scanning means 110 can be scanned to target object, and obtain corresponding scan data.The target object can be people Body, animal, inanimate etc..For example, the target object can include organ, vertebra, bone, the group of human body or animal Knit, blood vessel etc., or for the non-biological specimen of calibration system parameter.Imaging scanner 110 can be or be swept including one Retouch unit.The scanning element can include a positron emission tomography (positron emission Tomography, PET) scanning element, computer tomography (computed tomography, CT) scanning element, magnetic resonance Imaging (magnetic resonance imaging, MRI) scanning element, B ultrasonic imaging (b-scan ultrasonography) One or more in scanning element, hot Tomography (Thermal texture maps, TTM) scanning element etc.. In some embodiments, scanned imagery device 110 can include multiple PET scan units and a CT scan unit.

In certain embodiments, imaging scanner 110 may further include a scanning bed and drive device (being indicated not in figure).It is described scanning bed to can be used for support target object.The drive device can be used for drive one or Multiple scanning element motions.The specific embodiment of imaging scanner 110 may refer to the description of the application other parts.

Computer equipment 120 can be associated with imaging scanner 110.In certain embodiments, computer equipment 120 can To receive the scan data of the acquisition of imaging scanner 110, and corresponding image is generated based on the scan data.In some realities Apply in example, computer equipment 120 can include a console.By the console, user is (for example, doctor, is imaged technician Deng) imaging scanner 110 can be controlled to be scanned target object (for example, patient).The tool of computer equipment 120 Body implementation method may refer to the description of the application other parts.

In certain embodiments, imaging system 100 can be connected to network by computer equipment 120.The network can With including wired connection or wireless connection.In certain embodiments, the network can be single network, or various The combination of network.For example, the network can include LAN, wide area network, common network, dedicated network, WLAN, void Intend the combination of one or more in network, city Metropolitan Area Network (MAN), public switch telephone network etc..The network can include various Network Access Point, such as wired or wireless access point, base station or network exchange point.Each part in imaging system 100 can The network is connected with by above access point, the interaction of information is realized.For example, imaging system 100 can be by the network A public medical system is connected to, Historical medical's information of patient or the medical data of synchronous patient is obtained.

In certain embodiments, imaging system 110 can be set by the network with outside server, database or terminal It is standby to be connected with each other and communicated.The server or database can be used for information Store and acquisition.The server can be with In being file server, database server, ftp server, apps server, proxy server, mail server etc. The combination of one or more.In certain embodiments, the server can be a Cloud Server.The database can be with It is the combination of one or more therein such as hierarchical database, network database and relational database.The terminal sets The standby information that can receive the output of imaging system 110, including the prescription issued of medical diagnosis on disease report, doctor or user's request are looked into Other information seen etc..In certain embodiments, the terminal device can include notebook computer, mobile phone, panel computer, control One or several combination in platform processed, Intelligent worn device (such as intelligent watch) etc..

Fig. 2A is the schematic diagram according to example imaging scanner in the application some embodiments.Imaging scanner 110 205, CT scan unit 210 of a PET scan part and a drive device 215 can be included.PET scan part 205 One or more PET scan units, such as PET scan unit 1, PET scan unit 2 ..., PET scan unit n can be included. In some embodiments, one or more of PET scan units can be separate unit.In certain embodiments, institute It at least partly can be to be mutually related to state one or more PET scan units.

The PET scan unit can carry out PET scan to target object, and obtain corresponding PET scan data.It is described PET scan unit can include one or more detector rings (annular detector).The detector rings can be by multiple rings The detecting element composition of array arrangement.In certain embodiments, the quantity of the detecting element can with the precision of detector and Spatial resolution is related.The detecting element can be wedge-shaped, square or other shapes.In certain embodiments, the detection Element can be wedge shape.Wedge-shaped detecting element can closely fit each other, constitute a complete detector rings.One In a little embodiments, the detecting element can be made up of crystal and photomultiplier.In certain embodiments, the detecting element Can be made up of crystal and silicon photomultiplier (SiPM).Signal in detector rings investigative range can be connect by the crystal Receive, and amplified by the photomultiplier, be convenient for further treatment.In certain embodiments, a PET scan unit can With including multiple detector rings.The multiple detector rings can be arranged axially, have PET scan unit wider Axial scan scope (the axial scan visual field).In some implementation illustrations, the multiple PET scan units in PET scan part 205 (such as PET scan unit 1, PET scan unit 2 ..., PET scan unit n) can have identical or different axial direction or footpath To scan vision.For example, PET scan unit 1 can be made up of two detector rings, PET scan unit 2 can by three or with Upper detector rings are constituted.PET scan unit 2 can have the broader axial scan visual field compared with PET scan unit 1.One In a little embodiments, the axially or radially scan vision of PET scan unit can with the diameter of detector rings, quantity and/or its in The correlations such as the shape of portion's detecting element, quantity or type.

Before PET scan, can be to injecting one or more contrast agent in target object.In certain embodiments, institute It can be the material needed for organism metabolism to state contrast agent.For example, the contrast agent can include glucose, protein, nucleic acid, Aliphatic acid etc..In certain embodiments, it is possible to use one or more radionuclide is marked to the contrast agent.It is described Radionuclide can include F18, C11 etc..In certain embodiments, the contrast agent can be using the fluorine of F18 isotope labelings For deoxyglucose (FDG).In certain embodiments, the positive electron that the radionuclide is included can be with corresponding position Negatron is combined, the photon that generation is launched for a pair round about.Crystal in PET scan unit can obtain the photon, And as PET scan data.In certain embodiments, by setting one or more PET scan parameters, PET scan unit can To obtain specific PET scan data.For example, when the PET scan parameter can include meeting window width, scan vision, scanning Between etc..

In certain embodiments, the multiple PET scan unit can have identical structure.For example, PET scan unit Detector rings inside 1 can have identical diameter, identical detecting element with the detector rings inside PET scan unit 2 Type and identical detector rings quantity.In certain embodiments, the multiple PET scan unit can be scanned based on identical Parameters on target object is scanned.For example, PET scan unit 1 can have and the identical sweep parameter of PET scan unit 2 (for example, meeting window width, scan vision, sweep time etc.).

In certain embodiments, the multiple PET scan unit can have different structures.For example, PET scan unit Detector rings inside 1 can have small diameter, for being scanned to patients head；Detection inside PET scan unit 2 Device ring has larger diameter, for being scanned to patient's body portion (for example, the position such as heart, belly).In some embodiments In, the multiple PET scan unit can be scanned based on different sweep parameters to target object.For example, PET scan list Unit 1 can have the sweep parameter (for example, meet window width, scan vision, sweep time etc.) different from PET scan unit 2.

CT scan unit 210 can carry out CT scan to target object, and obtain CT scan data.CT scan unit 210 A radioactive source and a detector can be included.The radioactive source can be with object-oriented object emission radioactive ray.One In a little embodiments, radioactive source can include radiographic source, radiographic source, radiographic source, x-ray source, neutron radiation source, electronic emission source Deng.The ray of radiographic source transmitting can be fan-ray beam (fan beam), parallel beam (parallel beam), Cone beam (cone beam) etc..In certain embodiments, CT scan unit 205 can include multiple radioactive sources.It is described many Individual radioactive source can be the radioactive source of same type, or different types of radioactive source.

The detector can receive the ray through the target object, and be transformed into the accessible letter of computer Number.In certain embodiments, the ray that the detector will can be received is converted to visible ray, and is further converted into telecommunications Number.After the electric signal can be changed by analog/digital converter, computer equipment 120 is sent to for being imaged.The detection Device can be one or more in curved detector, circular detector, square detector etc..In certain embodiments, it is described Detector can be curved detector.In certain embodiments, CT scan unit can include multiple detectors.The multiple device Can axially arrange, constitute detector array.In certain embodiments, CT scan unit may further include one or Multiple sensors.One or more of sensors can be used for monitoring the running status of radioactive source and detector (for example, radiation The operational factors such as length of delay when source voltage, radiation ource electric current, detector temperature, detector conversion scan signal).It is one Or multiple sensors can be including temperature sensor, voltage sensor, current sensor etc..

In certain embodiments, by setting one or more CT scan parameters, CT scan unit 210 can be with corresponding Mode is scanned to target object.For example, the CT scan parameter can include sweep time, sweep speed, emission source electricity Pressure value, emission source current value etc..For example, by setting emission source magnitude of voltage and current value, CT scan unit can be with specific Power scan target object, and obtain corresponding CT scan data.

Drive device 215 can be used for driving PET scan part 205 and CT scan unit 210.In certain embodiments, PET scan part 205 and/or CT scan unit 210 may be mounted in drive device 215.In certain embodiments, PET sweeps Retouching part 205 and/or CT scan unit 210 can be installed on by modes such as slide rail, chain, belt, screw, bolt, buckles Drive device 215.

In certain embodiments, drive device 215 can include a driver.The driver can be used for driving peace PET scan part 205 and/or CT scan unit 210 in the drive device are moved.The driver can be using electricity Power, hydraulic pressure, air pressure or its type of drive for combining.In certain embodiments, the driver can be or including an electricity Machine.The motor can drive the PET scan part 205 and/or CT scan unit 210 to transport by way of driven by power It is dynamic.As an example, the motor can be including slowspeed machine (such as reducing motor, claw electrode synchronization electromotor), high-speed electric expreess locomotive, constant speed In motor, buncher (such as electromagnetic adjustable speed motor, switched reluctance variable speed machine, DC speed-regulating motor), linear electric motors one Plant or several combinations.

By the driver, drive device 215 can respectively drive PET scan part 205 and/or CT scan unit 210 motions.The motion can include axial translation, ring rotation, wallowing motion or its combination.For example, drive device 215 can separately drive PET scan unit 1, PET scan unit 2 ..., the axially translated extremely fingers of PET scan unit n Positioning is put.Again for example, drive device 215 can drive CT scan unit 210 while carrying out axial translation and ring rotation, realize Spiral sweep to target object.In certain embodiments, imaging scanner 110 can include multiple drive devices 215. In PET scan unit 1, PET scan unit 2 ..., PET scan unit n and/or CT scan unit 210 any one or it is many It is individual to may be mounted in different drive devices.In certain embodiments, at least one of PET scan part 205 PET scan Unit can be maintained static.Drive device 215 can drive other PET scan units to be axially moveable.For example, PET scan list Unit 1 can be scanned with axial restraint to patients head；Drive device 215 can drive one or more PET scan units (for example, PET scan unit 2 ..., PET scan unit n) are axially moveable, to patient's trunk, four limbs etc., other positions are carried out Scanning.

For those skilled in the art, after the principle for understanding imaging scanner, may be without departing substantially from this In the case of principle, unit is combined, or constitutes subelement and be connected with other units, to implementing above-mentioned dress The various amendments and change in application field form and details put, but these amendments and change are still in scope described above Within.For example, imaging scanner 110 can only include PET scan part 205 and drive device 215.Again for example, imaging is swept Imaging apparatus 110 may further include a MRI scan unit, and magnetic resonance imaging is carried out to target object.Again for example, imaging is swept Imaging apparatus 110 can also include a user interface.By the interface, user can be to PET scan part 205, CT Scanning element 210 and/or drive device 215 are operated.

Fig. 2 B are the schematic diagrames according to example computer in the application some embodiments.Computer equipment 120 can be with Communicated including the processor 260, of controller 255,265, one, an input/output interface memory 270 and one Interface 275.Controller 255 can be used for judging decision-making, and generate control instruction.Controller 255 can receive logical Request or the command information of the input of input/output interface 265 are crossed, the information being input into by communication interface 275, processor 260 is given birth to Into information or memory 270 in information.Based on described information, controller 255 can judge decision-making, and generate control Instruction.In certain embodiments, the control instruction can be sent to imaging scanner 110, for setting sweep parameter And/or drive each scanning element movement.For example, controller 255 can refer to the control of mobile PET scan unit to the position Order is sent to drive device 215, for driving the PET scan unit to be moved to target location.In certain embodiments, it is described Control instruction can be sent to one or more parts in computer equipment 120.For example, the control instruction can be sent out Input/output interface 265 is delivered to, for pointing out user to be input into or other control operations.

In certain embodiments, controller 255 can be the control element or equipment in computer equipment 120.For example, control Device processed 255 can be microcontroller (microcontroller unit, MCU), central processing unit (central processing Unit, CPU), PLD (programmable logic device, PLD), application specific integrated circuit (application specific integrated circuits, ASIC), one chip microcomputer (single chip Microcomputer, SCM), System on Chip/SoC (system on a chip, SoC) etc..Again for example, controller 255 can be special The element or equipment that possess specific control function of different design.

Processor 260 can be used for processing data.Processor 260 can obtain information from imaging scanner 110, pass through Input/output interface 265 obtains information, and information is obtained from memory 270, or by acquisition information of communication interface 275 etc.. In some embodiments, processor 260 can be processed the information for getting by one or more processing method.The place Reason method can include fitting, interpolation, discrete, analog-to-digital conversion, transform, Fourier transformation, LPF, edge denoising, feature Extraction, image reconstruction, image enhaucament etc..In certain embodiments, processor 260 can perform flow described in Fig. 4 and/or Fig. 9 In reconstruction or generation scan image operation.

Processor 260 can be central processing unit (central processing unit, CPU), digital signal processor The treatment such as (digital signal processor, DSP), graphic process unit (graphics processing unit, GPU) Element or equipment.In certain embodiments, processor 260 can also be particular design the treatment element for possessing specific function or Equipment.For example, processor 260 can be according to digital imaging and communications in medicine (Digital Imaging and Communications in Medicine, DICOM) standard design treatment element or equipment.

Input/output interface 265 can be used for receiving user input information, or the information that computer equipment 120 is produced Export to user.The information being input into by input/output interface 265 can be including numeral, text, image, sound, video etc.. The form that input/output interface 265 obtains the information from user can include the hand-written operation of user, mouse action, touch screen behaviour Work, button operation, acoustic control operation, gesture operation, expression in the eyes operation, voice operating etc..It is input into by input/output interface 265 Information can be saved to memory 270, or be sent to controller 255 or processor 260 is further processed.Calculate Machine equipment 120 can export result by input/output interface 265, or the request of acquisition information is sent to user.One In a little embodiments, the information of the output of input/output interface 265 can be numeral, text, sound, image, light, vibrations etc. The combination of one or more.

In certain embodiments, input/output interface 265 can be input into or output information by physical interface, such as be touched Display screen, microphone, loudspeaker, LED light, button, button etc..In certain embodiments, input/output interface 265 can With using virtual interface input or output information, such as virtual reality, hologram.In certain embodiments, input/output interface 265 can be LCD display, LED light, loudspeaker, button, button on computer equipment 120 etc. one or more Combination.

Memory 270 can be the function that computer equipment 120 provides storage information.The shape of the storage information of memory 270 Formula can be text, numeral, sound, image etc..Memory 270 can be performed with store controller 255 and/or processor 260 Instruction or code, when controller 255 and/or processor 260 perform these codes, cause computer equipment 120 to perform sheet The one or more functions of the computer equipment 120 disclosed in application.In certain embodiments, memory 270 can include but It is not limited to common all kinds of storage devices such as solid state hard disc, mechanical hard disk, USB flash memory, SD storage cards, CD, random access memory (random-access memory, RAM) and read-only storage (read-only memory, ROM) etc..In some embodiments In, memory 270 can be the storage device of internal system, and the external storage equipment of system, the network storage outside system sets Standby (memory such as on cloud storage service device) etc..

The communication that communication interface 275 can be set up between computer equipment 120 and network or other external equipments.It is described logical The mode of letter can include wire communication and radio communication.Wire communication can include by wire, cable, optical cable, waveguide, receive The transmission mediums such as rice material are communicated, and radio communication can include the serial wireless LAN communications of IEEE 802.11, IEEE 802.15 serial radio communications (such as bluetooth, ZigBee etc.), mobile communication (such as TDMA, CDMA, WCDMA, TD-SCDMA, TD-LTE, FDD-LTE etc.), satellite communication, microwave communication, scatter communication etc..In certain embodiments, communication interface 275 can be with It is conventional communication interface (for example, RS485, RS232 etc.), or according to the interface of specific criteria particular design.For example, Communication interface 275 can be according to digital imaging and communications in medicine (Digital Imaging and Communications in Medicine, DICOM) standard design communication interface.

For those skilled in the art, after the computer equipment principle for understanding, may be without departing substantially from it In the case of principle, all parts are combined, or constitute subassembly and be connected with miscellaneous part, to implementing above-mentioned system Various amendments and change in the application field form and details of system, but these amendments and change are still in scope described above Within.For example, controller 255 and processor 260 can be integrated in jointly a System on Chip/SoC (system on a chip, SoC on), for processing data and judging decision-making, and control instruction is generated.

Fig. 3 is the schematic diagram based on example imaging system in the application some embodiments.Imaging system 100 can include one The image-forming module 330, one of control module 320, of individual scan module 310, input/output module 340, stores mould Block 350 and a communication module 360.Connection in system between each module can be it is wired, it is wireless, or both knot Close.Any one module can be it is local, it is long-range, or both combination.The corresponding relation of intermodule can be a pair One, or it is one-to-many.For example, imaging system 100 can include multiple scan modules 310 and multiple control modules 320.Each Control module 320 can respectively control a scan module 310 with the corresponding information of acquisition scans target.Again for example, imaging system System 100 can include multiple scan modules 310 and a control module 320.The control module 320 can control multiple scannings Module 310 is with the information of acquisition scans target.

Scan module 310 can be scanned to target object, and obtain corresponding scan data.In some embodiments In, scan module 310 can include one or more scanning elements.For example, the scanning element can include PET scan list Unit, CT scan unit, MRI scan unit, B-scan unit, hot tomoscan unit etc..The data that scan module 310 is obtained can With disconnected including positron emission computerized tomography data, X-ray scanning data, magnetic resonance scanning data, sonographic data, heat Layer scan data etc..The scan data may come to one or more target such as body, organ, tissue metabolism, focus Scanning.In certain embodiments, scan module 310 can include one or more image scanning units and one or more Drive device.For example, image-forming module 310 can include at least two PET scan units, a CT scan unit and a drive Dynamic device.

In certain embodiments, the scan data that scan module 310 is obtained can be sent to control module 320, be used for Judge decision-making.In certain embodiments, the scan data that scan module 310 is obtained can be sent to image-forming module 330, be used for Rebuild scan image.In certain embodiments, the scan data that scan module 310 is obtained can be stored to memory module 350. In certain embodiments, scan module 310 obtain scan data can by communication module 360 be sent to network or with net Database, server or terminal device that network is connected.In certain embodiments, scan module 310 can be swept by one or more Device realization is retouched, for example, imaging scanner 110.

Control module 320 can provide decision information for imaging system 100, and generate the control instruction of correlation.Control mould Block 320 can receive the request or command information being input into by input/output module 340, the letter being input into by communication module 360 Breath, the information in the image or result, or memory module 350 of the generation of image-forming module 330.Based on described information, mould is controlled Block 320 can judge decision-making, and generate control instruction.For example, control module 320 can receive user by input/it is defeated Go out the information of the input of module 340, determine one or more PET scan positions, and generate the corresponding PET scan unit of movement to institute State the control instruction of one or more PET scan positions.In certain embodiments, the control instruction can be sent to scanning Module 310, for setting sweep parameter and/or driving each scanning element movement.For example, control module 320 can be by mobile PET Scanning element to the control instruction of the position is sent to scan module 310, for driving the PET scan unit to be moved to mesh Cursor position.In certain embodiments, the control instruction can be sent to other modules in imaging system 100.For example, institute Stating control instruction can be sent to input/output module 340, for pointing out user to be input into or other control operations. In some embodiments, control module 320 can be realized by one or more control element or equipment, for example, computer equipment 120 In controller 255.

Image-forming module 330 can process the scan data of the acquisition of imaging system 100, and generate image.The scan data A CT scan or PET scan acquisition can be performed to target object by scan module 310, be obtained from memory module 350, or Obtained by communication module 360.In certain embodiments, image-forming module 330 can carry out pre- place to the scan data for getting Reason.The pretreatment can be including filtering, regularization etc..In certain embodiments, image-forming module 330 can be based on described image Data, reconstruction image.Image reconstruction operation can be including interpolation, fitting, iteration, Fourier transformation, convolutional back-projection etc..One In a little embodiments, image-forming module 330 can be post-processed to the image after reconstruction.The post processing can increase including image By force, image segmentation, image denoising, the geometric correction of imagery, Edge Gradient Feature, image co-registration etc..In certain embodiments, it is imaged Module 330 can be realized by one or more treatment element or equipment, for example, the processor 260 in computer equipment 120.

Input/output module 340 can be used for receiving user input information, or the information hair that imaging system 100 is generated Give user.The information being input into by input/output module 340 can be including numeral, text, figure, sound etc..For example, user One or more operational orders can be input into by input/output module 340.The operational order can include scan module 310 sweep parameter sets instruction, image processing requests etc..The information being input into by input/output module 340 can be saved To memory module 350, or it is sent to control module 320 or image-forming module 330 is further processed.Input and output/mould Block 340 can be by one or more form output information of light, word, sound, image, vibrations etc..For example, imaging system 100 medical images that generation can be exported by input/output module 340.In certain embodiments, input/output module 340 Can be or including one or more physical components or equipment, such as touch display screen, LED light, loudspeaker, microphone. In certain embodiments, the input/output module 340 can be integrated on a console of imaging system 100.At some In embodiment, input/output module 340 can be realized by one or more input/output interface or equipment, for example, computer Input/output interface 265 in equipment 120.

The information that memory module 350 can be obtained and generated with storage imaging system 100.The information of the storage of memory module 350 Can include scan module obtain 310 obtain scan datas, control module 320 produce decision information and/or control instruction, The scan data result of the generation of image-forming module 330, the information obtained by input/output module 340, by communication module Obtain 360 information etc..The form of the storage information of memory module 350 can be text, form, image, video etc..In some realities In applying example, memory module 350 can be local storage, external storage, the storage connected by communication module (such as cloud storage Deng) etc..In certain embodiments, memory module 350 can be by one or more storage device realization, for example, computer equipment Memory 270 in 120.

The communication that communication module 360 can be set up between imaging system 100 and network or other external devices.It is described logical The mode of letter can include wire communication and radio communication.Wire communication can include by wire, cable, optical cable, waveguide, receive The transmission mediums such as rice material are communicated, and radio communication can include the serial wireless LAN communications of IEEE 802.11, IEEE 802.15 serial radio communications (such as bluetooth, ZigBee etc.), mobile communication (such as TDMA, CDMA, WCDMA, TD-SCDMA Deng), satellite communication, microwave communication etc..In certain embodiments, the data type that communication module 360 can be transmitted as needed Or the different type of network, select different transmission means.

By communication module 360, imaging system 100 can be connected to network.The network can be single network, or many Plant the combination of network.In certain embodiments, the network can include multiple network access point, such as wired or wireless access Point, base station or network exchange point etc..By an access point, imaging system 100 can be connected with network and be sent by network Or receive information.In certain embodiments, imaging system 100 can by communication module 360 be connected to network server, Database or terminal device carry out information exchange.In certain embodiments, communication module 360 can be connect by one or more communication Mouth or device are realized, for example, the communication interface 275 in computer equipment 120.

Fig. 4 is the flow chart based on the illustrative methods that scan image is generated in the application some embodiments.In 401, Control module 320 can set sweep parameter.The sweep parameter can include CT scan parameter and/or PET scan parameter.Institute State CT scan parameter and can include but are not limited to sweep time, sweep limits, targeting information, scanning bed position, CT and sweep Retouch finite element rotation speed, scanning bed feed speed, voltage x current intensity, signal acquisition frequency etc..The PET scan parameter can be with Include but are not limited to sweep time, axial scan scope, targeting information, scanning bed position, scanning bed feed speed, adopt Sample frequency, meet window width, collection axial scan visual field etc..The sweep parameter can be default value, by user by input/it is defeated Go out module 340 to set, or the self-adaptative adjustment of imaging system 100.In certain embodiments, the sweep parameter can be according to waiting to sweep The target object retouched and set.The target object can be including human body, animal, inanimate etc..As an example, object Body can include any combination at limbs, organ, tissue, tumor locus or above-mentioned position.For example, 100 pairs of trouble of imaging system When person's head and belly carry out PET scan, different sweep times can be selected, meet window width, sweep limits, scanning bed feeding The PET scan parameter such as speed.Based on the sweep parameter, control module 320 can generate corresponding control instruction.

In 402, scan module 310 can be scanned to target object.Scan module 310 can receive control module The control instruction of 320 generations, is scanned to target object.In certain embodiments, one or more scanning elements (for example, PET scan part 205 and CT scan unit 210) target object can be entered by way of object-oriented object emission wave beam Row scanning.For example, the wave beam can include beam, beam, beam, X-ray beam, neutron beam, electron beam, visible ray Beam etc..In certain embodiments, one or more of scanning elements can be by receiving the side of the wave beam from target object Formula is scanned to target object.For example, the wave beam can be including photon beam, infrared beams etc..It is one or more of Scanning element can be scanned with one or more scan mode to target object.The scan mode can sweep including translation Retouch, rotation sweep, helical scanning, swing-rotation sweep etc..

In 403, scan module 310 can obtain scan data.Scan module 310 can be by one or more signals Obtain element (for example, detector rings or detecting element in detector, PET scan unit in CT scan unit) and obtain scanning Data.In certain embodiments, scan module 310 can obtain scan data by one or more conversion process.For example, sweeping Retouching module 310 can be converted to visible light signal by the X-ray signal of acquisition.Again for example, imaging system 100 can will be seen that light Signal is converted to curtage signal.Again for example, the analog signal of acquisition further can be converted into number by scan module 310 Word signal, so as to be converted to the manageable scan data of image-forming module 330.

In 404, image-forming module 330 can generate scan image according to the scan data for obtaining.In some embodiments In, image-forming module 330 can receive the scan data of the acquisition of scan module 310, generate scan image.Image-forming module 330 can be with The scan data for obtaining is processed by one or more processing mode, to generate image.The processing mode can be wrapped Include pretreatment, image reconstruction, post processing etc..The pretreatment can include to obtain scan data be filtered, it is discrete, go Make an uproar.Described image is rebuild can include Fourier transformation, convolutional back-projection, iteration, interpolation, fitting etc..Swept for different Data are retouched, imaging system 100 can select different image reconstruction algorithms.For example, for PET scan data, image-forming module 330 Conjugate gradient method (Conjugate gradient), MAP estimation method (Maximum A can be used Posteriori), the method such as iterative method rebuilds scan image；For CT scan data, image-forming module 330 can be anti-using filtering The methods such as projection reconstruction algorithm, Radon inversion algorithms, the Hilber conversion of image rebuild scan image；For MRI scan number According to image-forming module 330 can rebuild scan image using methods such as Fourier transformation, interpolation, iteration.

The scan image can be including PET scan image, CT scan image, MRI scan image etc..In some embodiments In, described image can be any combination of above-mentioned scan image.For example, image-forming module 330 can based on PET scan data and CT scan data, rebuilds PET/CT images.Again for example, image-forming module 330 can be based on PET scan data and MRI scan data, Rebuild PET/MRI images.In certain embodiments, image-forming module 330 can be by one or more post-processing approach to rebuilding Image processed.The post-processing approach can include virtual color display, edge regularization, split based on region, Image rendering, image distortion correction, artifact correction etc..The pretreatment, image reconstruction and post processing can be by linear algebra, micro- One or more realization in the methods such as integration, numerical analysis, image procossing, Digital Signal Processing.

It should be noted that description of the above for the process of generation scan image, only for convenience of description, can not be this Application is limited within the scope of illustrated embodiment.It is appreciated that for a person skilled in the art, understanding the flow Afterwards, each step may be exchanged or is combined in the case of without departing substantially from this principle, to implementing the above method With the various amendments and change in systematic difference field form and details.For example, imaging system 100 can by reconstruction after sweep Tracing is as being stored or being exported.

Fig. 5 is based on a schematic diagram for sample scan module in the application some embodiments.Scan module 500 can be wrapped Include a CT scan unit 510, PET scan unit 521 and PET scan unit 522, scanning bed 530 and and drive dress Put 550.

Scanning bed 530 can be with support target object (for example, patient 540 to be scanned).In certain embodiments, it is scanning bed 530 bed board can axially (Z-direction in figure) movement.The movement of the bed board can be controlled by control module 320.Sweeping During retouching, control module 320 can control scanning bed 530 bed board to move through one or more scanning lists along Z-direction The scanning area of unit, to realize the scanning to target object.The speed of scanning bed 530 bed board movement can be constant or become Change.In certain embodiments, the speed of scanning bed 530 bed board movement can join with sweep time, Scanning size etc. Number is related.In certain embodiments, the speed of scanning bed 530 bed board movement can be a default value, it is also possible to by user Set by input/output module 340, or the self-adaptative adjustment of imaging system 100.For example, user does not set scanning bed 530 bed During the translational speed of plate, control module 320 can determine that scanning bed bed board translational speed is default value；Imaging system 100 is received To user setting scanning bed 530 bed board translational speed when, control module 320 can determine scanning bed 530 bed board Translational speed is user's setting value.In certain embodiments, scanning bed 530 bed board can be with remains stationary.In scanning process, Control module 320 can control CT scan unit 510, PET scan unit 521 and/or PET scan unit 522 to be axially moveable And by target object, to realize the scanning to target object.

In certain embodiments, control module 320 (Z-direction in figure) can carry out one-dimensional volume to scanning bed 530 vertically Code, generates the bed code value of scanning bed 530 each position.In certain embodiments, by set scanning bed 530 start position (for example, Scanning bed 530 one end 530-1) bed code value be zero, it may be determined that the bed code value of optional position on scanning bed 530.Institute's rheme The bed code value put can correspond to the relative distance of the position and the start position.In certain embodiments, the position Bed code value can be equal to the relative distance of the position and the start position.Scanning bed 530 bed code value can be with numeral, text The forms such as sheet, form, polar plot are stored in memory 270.In certain embodiments, control module 320 can be to scanning bed 530 carry out the coding on two dimension or three-dimensional.

In certain embodiments, scanning bed 530 can be including lifting linking member, the transmission mechanical device such as parts.The machine Tool device can be used for lifting, overturning scanning bed 530 bed body.The lifting of scanning bed 530 bed body can integrally rise including bed body Drop, inclined lift etc..The lifting of the bed body, upset can be controlled by control module 320, user adjusts or be imaged system manually System 100 needs self-adaptative adjustment according to scanning.

CT scan unit 510 can carry out CT scan to target object, and obtain CT scan data.CT scan unit 510 An a radioactive source 510-1 and detector 510-2 can be included.In certain embodiments, radioactive source 510-1 can be that X is penetrated Ray tube.In scanning process, radioactive source 510-1 can launch radioactive ray towards patient 540.Due to histological difference, suffer from Person's body different parts can have different degrees of absorption to incident ray.Therefore from penetrating that each position of patient body transmits Line can have different intensity.Detector 510-2 can receive the transmitted ray of varying strength, generate CT scan data. In some embodiments, the transmitted ray can be related to one or more sweep parameters of CT scan unit 510.The scanning Parameter can be including sweep time, sweep limits, CT scan finite element rotation speed, radioactive source voltage x current value etc..In some realities Apply in example, CT scan unit 510 can be scanned with one or more scan mode to patient.The scan mode can be wrapped Include translation scan, rotation sweep, helical scanning, swing-rotation sweep axially etc..In certain embodiments, CT scan The translation vertically of unit 510, rotation, swing can be driven by drive device 550.

Image-forming module 330 can be based on the CT scan data that CT scan unit 510 is obtained, CT image reconstruction.CT image weights The technology of building can include that parallel beam projection algorithm, parallel beam backprojection-filtration algorithm for reconstructing, fladellum backprojection-filtration are rebuild and calculate Method, iterative reconstruction algorithm etc..As an example, parallel beam projection algorithm can include direct Fourier transform reconstructions algorithm, filtering Backprojection reconstruction algorithm, Radon inversion algorithms etc..Parallel beam backprojection-filtration algorithm for reconstructing can include function of a single variable Hilber conversion of Hilber conversion, image in Hilber conversion, finite interval etc..Image-forming module 330 can obtain CT and sweep Retouch the CT scan figure of the entire patient of the collection of unit 510 or the scan data of local location, reconstruction patients whole body or local location Picture.

In certain embodiments, image-forming module 330 can carry out one or more treatment to the CT images after reconstruction.It is described Treatment can be including image enhaucament, image segmentation, artifact removal, Image Coding etc..In certain embodiments, image-forming module 330 Scanning bed 530 bed code value can be based on, the CT images are encoded, (such as what is shown in Fig. 5 shows generation CT spacers The CT spacers 560 of example).A position in the CT spacers can correspond to scanning bed 530 relevant position.At some In embodiment, the encoded radio in the scanning bed 530 corresponding CT spacers of same position can be with identical with the bed code value of the position. For example, the encoded radio in CT spacers is that the position that bed code value of the position of z1 and z2 with corresponding scanning bed 530 is z1 and z2 can Being identical position.The coding can be one-dimensional coding, two-dimensional encoded or 3-dimensional encoding.In certain embodiments, it is described Scan image in CT spacers can have certain precision.By CT spacers, control module 320 can determine one or Multiple semi-cylindrical hills (region of interest, ROI), for example, organ in patient's body, abnormal tissue etc..One In a little embodiments, the CT spacers may be used to determine whether region to be scanned (for example, certain organ, the area of abnormal structure Domain etc.), so that it is determined that one or more PET scan positions.Control module 320 can obtain one or more of PET scans Position, and control one or more PET scan units to be moved to corresponding PET scan position.

PET scan unit 521 can be scanned to target object, and generate PET scan data.PET scan unit 521 Multiple pet detectors ring (as shown in FIG., pet detector ring 521-1, pet detector ring 521-2 etc.) can be included. Before PET scan, can be to making of injecting that one or more radionuclide (such as F18, C11 etc.) mark in the body of patient 540 Shadow agent.The radionuclide can produce positive electron in decay process in patient's body.The positive electron and adjacent position Negatron combine after bury in oblivion, the photon launched round about for a pair can be produced.Detector in PET scan unit 521 Ring can obtain the photon pair, used as PET scan data.In certain embodiments, by setting one or more PET scans Parameter, PET scan unit 521 can obtain specific PET scan data.The PET scan parameter can include meet window width, Scan vision, sweep time etc..For example, by setting one or more PET scan parameters, the photon pair in opposite direction can Received with by two PET scan units, (cross coincidence) PET scan data is met as intersection.In some implementations In example, the intersection meets data can be received by two adjacent PET scan units.In certain embodiments, the intersection Meet PET scan data and can be sent to image-forming module 330 and processed.Image-forming module 330 can be by one or more Processing method meets data and processes to the intersection.For example, two adjacent PET scan cell distances farther out when, imaging Module 330 can be by way of meeting the intersection data and applying a weight coefficient or weight matrix, to the intersection Meet data to be corrected.The weight can be related to the distance between described two PET scan units.

In certain embodiments, the PET scan number that image-forming module 330 can be by one or more correction process to obtaining According to being corrected.The correction process can include radionuclide decay correction, tissue breakdown correction, accidental coincidence correction, Scatter correction, coincidence correction etc..In certain embodiments, image-forming module 330 can utilize the PET scan number after correction process According to carrying out image reconstruction.The reconstruction technique can be including filter back-projection reconstruction algorithm, iterative reconstruction algorithm etc..As showing Example, iterative reconstruction algorithm includes maximum likelihood-expectation maximization method (Maximum Likelihood-Expectation Maximum), conjugate gradient method (Conjugate gradient), MAP estimation method (Maximum A Posteriori) etc..In certain embodiments, imaging system 100 can be specific to patient body using PET scan unit 521 Position is scanned, and rebuilds the PET image of relevant position.

In certain embodiments, the specific embodiment of PET scan unit 522 can be similar to PET scan unit 521. In certain embodiments, PET scan unit 522 can have and the identical structure of PET scan unit 521.For example, PET scan Detector rings inside unit 522 can have identical diameter, identical with the detector rings inside PET scan unit 521 Detecting element type and identical detector rings quantity.In certain embodiments, PET scan unit 522 and PET scan unit 521 can be scanned based on identical sweep parameter to target object.For example, PET scan unit 522 can have and PET The identical sweep parameter of scanning element 521 (for example, sweep time, meet window width, scan vision etc.).

In certain embodiments, PET scan unit 522 can have the structure different from PET scan unit 521.For example, PET scan unit 522 compared with PET scan unit 521, can have different-diameter or varying number detector rings and/or Its detector rings can be made up of different shape, varying number or different types of detecting element.In certain embodiments, PET Scanning element 522 can have the sweep parameter different from PET scan unit 521.For example, PET scan unit 522 is swept with PET Unit 521 is retouched to compare, can have different counting rates, sweep time, scan mode (two-dimensional scan, 3-D scanning), window width, Bed etc..In certain embodiments, storage method, the image based on PET data of the PET data of the generation of PET scan unit 522 Algorithm for reconstructing etc. can be different from PET scan unit 521.

Drive device 550 can drive PET scan unit 521 and 522 and CT scan unit 510 to move.The motion Axial translation, ring rotation, wallowing motion or its combination can be included.For example, drive device 550 can be separately Drive PET scan unit 521 and PET scan unit 522 axially translated to specified location, target object is scanned.Again For example, the driver can drive, CT scan unit 510 carries out axial translation and ring rotates, and realizes the spiral shell to target object Rotation shape scanning.In certain embodiments, PET scan unit 521 and 522 and/or CT scan unit 510 may be mounted at driving dress Put on 550.In certain embodiments, imaging scanner 500 can include multiple drive devices.PET scan unit 521, PET Any one or more in scanning element 522 and CT scan unit 510 may be mounted in different drive devices.One In a little embodiments, at least one of PET scan unit 521 and 522 can be maintained static.Drive device 550 can drive separately One PET scan unit is axially moveable.For example, PET scan unit 522 can be scanned with axial restraint to patients head； Drive device 550 can drive PET scan unit 521 to be axially moveable, and to patient's trunk, four limbs etc., other positions are swept Retouch.

In certain embodiments, drive device 550 can drive PET scan unit 521 and 522 to move to corresponding PET Scan position, and the target object at the PET scan position is scanned.In certain embodiments, the PET scan position Putting can be determined by user.User can be by contact action, to button or button operation, gesture operation, voice operating, expression in the eyes The modes such as operation determine on the CT spacers one or more PET scan positions (for example, in CT scan piece 560 one or The position of multiple organs).For example, user can click on and drag the operation of mouse described by input/output module 340 One or more marks are drawn on CT spacers, for determining PET scan position.The mark can include point, circle, square frame, Or the figure with arbitrary shape.Control module 320 can receive described user's operation, and based on the user's operation for receiving Determine specified location.In certain embodiments, control module 320 can obtain one or more parameters of user input, be used for Determine position to be scanned.The parameter can be including Image Coding value, bed code value, Organ naming etc..For example, control module 320 Two bed code values of user input can be obtained, and the corresponding position of two bed code values of determination is two PET scan positions.One In a little embodiments, PET scan position can be determined by control module 320.If for example, being that target area is head for definition With two positions of heart, control module 320 can be according to the characteristic information of CT spacers and target site (such as border, CT values Deng), the heart and head position of human body in automatic identification this time scanning.

In certain embodiments, the PET scan position can be determined by control module 320.For example, being determined by contrasting CT The CT scan image of bit slice and normal human tissue, control module 320 can determine the corresponding position of one or more abnormal structures It is set to PET scan position.In certain embodiments, the PET scan position can be jointly true by control module 320 and user It is fixed.For example, control module 320 can select one or more PET scan positions (for example, by contrasting CT spacers and normal Can there is abnormal structure to one or more on the CT spacers in the CT scan image of tissue, control module 320 Position be identified).By input/output module 340, one or more PET that user can select to control module 320 Scan position is adjusted (for example, position of change mark).Control module 320 can receive described user's operation, and base Determine PET scan position in the user's operation for receiving.After determining PET scan position, control module 320 can be controlled to drive and filled 550 are put, drives one or more PET scan units to be moved to corresponding PET scan position, and to PET positions correspondence area Target object in domain is scanned.For example, control module 320 can control drive device 550, PET scan list is driven respectively Unit 521 is moved to the corresponding PET scan positions of z1 and z2 with PET scan unit 522, while thoracic cavity and belly to patient 540 It is scanned.

Fig. 6 is the flow chart based on the illustrative methods that PET scan parameter is set in the application some embodiments.At some In embodiment, step 401 and 402 in Fig. 4 can be realized by method 600.As shown in fig. 6, in 601, control module 320 can be with CT scan parameter is set.The CT scan parameter can include voltage, electric current, ray harness shape, sweep time, scan mode (for example, helical scanning, translation scan, rotation sweep etc.), sweep speed, sample frequency etc..CT scan parameter can be system Default value, is set by user by input/output module 340, or system self-adaption adjustment.For example, set CT scan parameter it Before, control module 320 can detect current system conditions (for example, the CT scan unit internal source arrived by Sensor monitoring Size of delay existed when stability, the detector conversion scan signal of voltage x current etc.).According to current system conditions, from Adapt to adjustment CT scan parameter.In certain embodiments, control module 320 is may further include in 601 CT data is set Storage parameter (for example, order, dimension of data matrix of filling sinogram data matrixes etc.), CT image reconstruction parameter (examples Such as, parallel beam backprojection-filtration reconstruction parameter, fladellum backprojection-filtration reconstruction parameter, iterative approximation parameter), CT image procossings Parameter (for example, image enhaucament parameter, image sharpening parameter, image denoising parameter) etc..In certain embodiments, the scanning ginseng Number can be set by user by input/output module 340.Based on the sweep parameter, control module 320 can be generated accordingly Control instruction.

In 602, scan module 310 can perform CT scan, and generate CT spacers.Swept based on the CT set in 601 Parameter is retouched, scan module 310 can carry out CT scan using CT scan unit to target object.The mode of scanning can include spiral shell Rotation scanning, rotation sweep, translation scan, swing-rotation sweep etc..In certain embodiments, CT scan unit in scanning process Rotation sweep can be carried out, while scanning bed 530 are axially translated.In certain embodiments, CT sweeps in scanning process Retouching unit can carry out helical scanning or roto-translatory scanning, scanning bed 530 transfixion.In certain embodiments, mould is scanned Block 310 can drive the CT scan unit to be scanned target object, and obtain CT scan number by drive device 215 According to.

After completing CT scan, image-forming module 330 can be based on the scan data that scan module 310 is obtained, CT image reconstruction. Reconstruction technique used by CT image reconstruction can include parallel beam projection algorithm, parallel beam backprojection-filtration algorithm for reconstructing, sector Beam backprojection-filtration algorithm for reconstructing, iterative reconstruction algorithm etc..As an example, parallel beam projection algorithm can be included directly Fourier transform reconstructions algorithm, filter back-projection reconstruction algorithm, Radon inversion algorithms etc..Parallel beam backprojection-filtration is rebuild and is calculated Method can include Hilber conversion, the Hilber conversion in finite interval, Hilber conversion of image of function of a single variable etc..One In a little embodiments, image-forming module 330 can carry out one or more post processing to the CT images after reconstruction.The post processing can be with Including image enhaucament, image segmentation, artifact removal, Image Coding etc..In certain embodiments, image-forming module 330 can be based on To scanning bed 530 coding, the CT images are encoded, CT spacer of the generation containing coding (such as shows in Fig. 5 The CT spacers 560 of example).The coding can be one-dimensional coding, two-dimensional encoded or 3-dimensional encoding.By coding, the CT A upper position of spacer can correspond to scanning bed 530 relevant position.In certain embodiments, scanning bed 530 it is same Encoded radio in the corresponding CT spacers in one position can be with identical with the bed code value of the position.

In 603, control module 320 can be based on the CT spacers, determine PET scan position.In some embodiments In, the PET scan position can be determined by user.User can be by input/output module 340, with contact action, to pressing The mode such as button or button operation, gesture operation, voice operating, expression in the eyes operation determines one or more on the CT spacers PET scan position is (for example, the PET scan position can correspond to the position of one or more organs in CT scan piece 560 Put).For example, user can by clicking on and drag mouse operation drawn on the CT spacers one or more mark, For determining PET scan position.The mark can include point, circle, square frame or the figure with arbitrary shape.Control module 320 can receive described user's operation, and determine PET scan position based on the user's operation for receiving.In some embodiments In, control module 320 can obtain one or more parameters of user input, for determining PET scan position.The parameter can With including Image Coding value, bed code value, Organ naming etc..For example, control module 320 can obtain two beds code of user input Value, and the corresponding position of two bed code values of determination is two PET scan positions.

In certain embodiments, the PET scan position can be determined by control module 320.For example, being determined by contrasting CT The CT scan image of bit slice and normal human tissue, control module 320 can determine the corresponding position of one or more abnormal structures It is set to PET scan position.In certain embodiments, the PET scan position can be jointly true by control module 320 and user It is fixed.For example, control module 320 can select one or more PET scan positions (for example, by contrasting CT spacers and normal Can there is abnormal structure to one or more on the CT spacers in the CT scan image of tissue, control module 320 Position be identified).By input/output module 340, one or more PET that user can select to control module 320 Scan position is adjusted (for example, position of change mark).Control module 320 can receive the adjustment operation, and be based on The user's adjustment operation for receiving determines PET scan position.In 604, scan module 310 can move PET units to described PET scan position.Scan module 310 can obtain the PET scan position that control module 320 determines in 603, mobile one or many Individual PET units are to corresponding position.In certain embodiments, scan module 310 marked described in CT spacers by that can be obtained Know corresponding Image Coding value, determine the position.In certain embodiments, if PET scan position is to pass through in 603 operation When one or more code values determine, scan module 310 can be based on the bed code value, mobile PET units to corresponding position. In certain embodiments, scan module 310 is by one or more drive devices (for example, drive device 215) movement PET Unit is to specified location.In certain embodiments, scan module 310 can pass through the bed board by translation scan bed bed board The scanning area of PET scan unit is crossed, to realize the scanning to patient's corresponding site.

In 605, control module 320 can set PET unit scan parameters.The PET scan parameter can include symbol Close window width, scan vision, sweep time etc..PET scan parameter can be a default value, it is also possible to by user by input/ Output interface 265 sets, or system self-adaption adjustment.For example, before setting CT scan parameter, control module 320 can be obtained The information such as the diameter of detector rings, width in PET scan unit, shape, quantity, the type of detecting element, and/or it is to be scanned Position etc..Based on above- mentioned information, control module 320 can be with self-adaptative adjustment PET scan parameter.In certain embodiments, in 605 Operation may further include setting PET data storage parameter, PET image reconstruction parameter, PET image processing parameter etc..

Fig. 7 is based on a schematic diagram for sample scan module in the application some embodiments.Scan module 700 can be wrapped Include 710, three PET scan unit 721-723 of a CT scan unit, one scanning bed 730 and a drive device 750.Sweep Retouching bed 730 can support patient 740.Drive device 750 can drive the CT scan unit 710 CT scan is carried out to patient 740, and Obtain scan data.During CT scan, scanning bed 730 bed board can be translated vertically, and CT scan unit 710 can It is pivoted with being driven by drive device 750, so as to realize the scanning to patient 740.After the end of scan, the scanning number According to image-forming module 330 can be sent to, for generating image.Image-forming module 330 can be based on what CT scan unit 710 was obtained CT scan data generates CT spacers (such as the example CT spacers 760 shown in Fig. 7).

Based on the CT spacers, control module 320 can determine one or more PET scan positions.In some implementations In example, the PET scan position can be determined by user.For example, user can drag the CT by way of contact action Positioning mark on spacer is to the region (such as head of patient, liver and belly) for needing to carry out PET scan.The positioning mark Knowledge can be including point, vertical line, tracking cross, circle, square frame etc..Control module 320 can receive described user's operation, and be based on The user's operation for receiving determines one or more PET scan positions.In certain embodiments, control module 320 can be obtained One or more parameters of user input, for determining PET scan position.The parameter can include Image Coding value, bed code Value, Organ naming etc..For example, control module 320 can obtain two bed code values of user input, and determine two bed code value institutes Corresponding position is two PET scan positions.

In certain embodiments, the PET scan position can be determined by control module 320.For example, being determined by contrasting CT The CT scan image of bit slice and normal human tissue, control module 320 can determine the corresponding position of one or more abnormal structures It is set to PET scan position.In certain embodiments, the PET scan position can be jointly true by control module 320 and user It is fixed.For example, control module 320 can select one or more PET scan positions (for example, by contrasting CT spacers and normal Can there is abnormal structure to one or more on the CT spacers in the CT scan image of tissue, control module 320 Position be identified).By input/output module 340, one or more PET that user can select to control module 320 Scan position is adjusted (for example, position of change mark).Control module 320 can receive the adjustment operation, and be based on The user's adjustment operation for receiving determines PET scan position.

After determining PET scan position, drive device 750 can respectively drive one or more PET scan units to be moved to Corresponding position, carries out PET scan.For example, according to CT spacers 760, control module 320 can determine the volume at position to be scanned Code value is respectively z1, z2 and z3.Control module 320 can be based on the position that described encoded radio z1, z2 and z3 correspond to scanning bed 730 Put, control drive device 750 drives PET scan unit 721, PET scan unit 722 and PET scan unit 723 to distinguish vertically It is moved to corresponding position.In certain embodiments, PET scan unit 721, PET scan unit 722 and PET scan unit 723 PET scan can be simultaneously carried out, the PET scan data of the scanning area corresponding to the scan position is obtained.For example, PET sweeps Retouching unit 721, PET scan unit 722 and PET scan unit 723 can be simultaneously to patients head region, chest area and belly It is scanned, and obtains scan data.The PET scan data can be sent to image-forming module 330, for rebuilding the area The PET scan image in domain.In some implementation illustrations, PET scan unit 721-723 can have identical or different axial direction or footpath To scan vision.For example, PET scan unit 721 can be made up of two detector rings, PET scan unit 722 and 723 can be with It is made up of three or more detector rings.PET scan unit 722 and 723 can have wider compared with PET scan unit 721 The axial scan visual field.In certain embodiments, at least one of PET scan unit 721,722 and 723 can be fixed not It is dynamic.Drive device 750 can drive remaining one or more PET scan unit to be axially moveable.For example, PET scan unit 721 Patients head can be scanned with axial restraint, drive device 750 can drive PET scan unit 722 and 723 vertically Mobile, to patient's trunk, four limbs etc., other positions are scanned.

For those skilled in the art, after the principle of the scan module for understanding, may be without departing substantially from its principle In the case of, all parts are combined, or composition subassembly is connected with miscellaneous part, to implementing said system Various amendments and change in application field form and details, but these amendment and change still scope described above it It is interior.For example, scan module 700 can include the PET scan unit of any amount (such as four, five or greater number). Again for example, can be with interrelated between the multiple PET scan region.Merely exemplary, control module 320 is receiving use (for example, being by the corresponding position of mark determination liver after draw one of family identifies and determines corresponding scan position One PET scan position), the multiple PET scan positions of quantity association (such as head, the renal tract of PET scan unit can be based on Etc. corresponding position), and PET scan is carried out to the multiple position.

Fig. 8 is the flow chart based on the illustrative methods that PET scan data is obtained in the application some embodiments.At some In embodiment, 800 operations for being included can be realized by the scan module described by the application other parts, for example, Fig. 3 institutes The scan module 310 of description, the scan module 500 described by Fig. 5, the scan module 700 described by Fig. 7, described by Figure 10 Scan module 1000, the scan module 1100 described by Figure 11, the scan module 1200 described by Figure 12, sweeping described by Figure 13 Retouch module 1300 etc..In 801, control module 320 can set CT scan parameter.The CT scan parameter can include electricity Pressure, electric current, ray harness shape, sweep time, scan mode, sweep speed, sample frequency etc..The CT scan parameter can be One default value, it is also possible to set by input/output interface 265 by user, or system self-adaption adjustment.In some embodiments In, the sweep parameter can be set by user by input/output module 320.Based on the sweep parameter, control module 320 can generate corresponding control instruction.

In 802, scan module 310 can perform CT scan based on the CT scan parameter is obtained.Scan module 310 The control instruction of the generation of control module 320 in 801 can be based on, image scanning be carried out to target object, and obtain scan data. After completing the image scanning, image-forming module 330 can obtain the scan data, for CT image reconstruction.CT image reconstruction Reconstruction technique used can include parallel beam projection algorithm, parallel beam backprojection-filtration algorithm for reconstructing, the filter of fladellum back projection Ripple algorithm for reconstructing, iterative reconstruction algorithm etc..In certain embodiments, image-forming module 330 can be carried out to the CT images after reconstruction Encoding operation.In certain embodiments, image-forming module 330 can based on scanning bed bed code value with to the corresponding of the CT images Relation is encoded, and generates CT spacers.In certain embodiments, 801 and 802 operations for being included can respectively with flow 601 and 602 operations for being included are same or similar in 600.

In 803, control module 320 can be based on the CT spacers, determine the scan position of PET scan unit 1. In some embodiments, the scan position of PET scan unit 1 can be determined by user.Control module 320 can position the CT Piece is by input/output module 340, or is sent to user by being external in one or more terminal devices of communication module 360. User the mode such as can operate described by contact action, to button or button operation, gesture operation, voice operating, expression in the eyes One or more PET scan positions are determined on CT spacers.For example, user can on the touchscreen by opening, closing up or moving Start refer to etc. operation draw one or more square frames on the CT spacers, for determining PET scan position.Control module 320 can receive described user's operation, and determine PET scan position based on the user's operation for receiving.In some embodiments In, control module 320 can obtain one or more parameters, for positioning PET scan unit.The parameter can include image Encoded radio, bed code value, the organ for needing scanning etc..For example, control module 320 can receive user by input/output module Two bed code values of 340 inputs, determine that the corresponding position of two bed code values is the scanning area of PET scan unit 1.

In certain embodiments, the scan position of the PET scan unit 1 can be determined by control module 320.For example, By contrasting the CT scan image of CT spacers and normal human tissue, control module 320 can determine one or more exceptions Organize the scan position that corresponding position is PET scan unit 1.In certain embodiments, the scanning of the PET scan unit 1 Position can jointly be determined by control module 320 and user.For example, control module 320 can select one or more PET scans (for example, the CT scan image by contrasting CT spacers and normal human tissue, control module 320 can be in the CT for position One or more positions that there is abnormal structure are identified on spacer).By input/output module 340, user can be with One or more PET scan positions that control module 320 is selected are adjusted (for example, position of change mark).Control mould Block 320 can receive the adjustment operation, and the scanning position of PET scan unit 1 is determined based on the user's adjustment operation for receiving Put.

After determining PET scan position, control module 320 can control PET scan unit 1 to be moved to corresponding position. In some embodiments, control module 320 can control PET scan unit 1 to be moved to certain position (such as head) of patient.One In a little embodiments, control module 320 can control scanning bed bed board to translate and by the scanning area of PET scan unit 1, with Realize the scanning to patient's corresponding site.In certain embodiments, 803 operations for being included can with flow 600 in 603 and 604 operations for being included are same or similar.

In 804 and 805, control module 320 can respectively control PET scan unit 2 and PET in scan module 310 to sweep Retouch unit 3 and be moved to specified location.In certain embodiments, the behaviour that 804 and 805 operations for being included can be included with 803 Make same or similar.For example, PET scan unit 2 can be moved and positioned to patient's heart position, PET scan unit 3 can be with Moved and positioned to patient's abdominal region.In certain embodiments, the operation in 803,804 and 805 can be carried out (i.e. simultaneously Control module 320 can control PET scan unit 1, PET scan unit 2 and PET scan unit 3 same based on the CT spacers When be moved to specified location).

In 806, control module 320 can set the sweep parameter of PET scan unit 1.The PET scan parameter can be with Including sweep time, sample frequency, window width, window position etc..PET scan parameter can be system default value, by user by input/ Output module 340 sets, or system self-adaption adjustment.For example, before CT scan parameter is set, control module 320 can be true Determine the information of PET scan unit and/or the information at position to be scanned.The information of the PET scan unit can include detector Diameter, the shape of width and/or detecting element, quantity, type of ring etc..The information at the position to be scanned can include waiting to sweep Retouch volume, maximum circumscribed circle diameter, the organization type at position etc..Based on described information, control module 320 can be with self-adaptative adjustment PET scan parameter.In certain embodiments, 806 operations for being included can be identical with 605 operations for being included in flow 600 Or it is similar.

In 807 and 808, control module 320 can set the sweep parameter of PET scan unit 2 and PET scan unit 3. In certain embodiments, 807 and 808 operations for being included can be same or similar with 605 operations for being included in flow 600. In certain embodiments, PET scan unit 1, PET scan unit 2 and PET scan unit 3 are set respectively in 806,807 and 808 The parameter put can be with identical or different.For example, the sweep parameter of PET scan unit 1 can be according to independent the need for head scanning It is configured, and the sweep parameter of PET scan unit 2 and 3 can need to carry out identical setting according to the scanning of body portion.

In 809, scan module 310 can gather PET data A.PET scan unit 1 can be based on 806 in set sweep Retouch parameter to be scanned certain position of patient, and gather corresponding scan data.For example, PET scan unit 1 can be with static Collection brain scans data.In certain embodiments, PET scan unit 1 can to translate, rotation, swing etc. it is middle a kind of or The scan mode of various combinations is scanned to certain position of patient, gathers corresponding scan data.In certain embodiments, PET scan data can be obtained by obtaining the photon pair produced in scanning area in real time.The PET scan data can be wrapped Include the forms such as curve, form, text.In certain embodiments, PET scan unit 1 can in real time gather sweeping for multiple moment Retouch data.The scan data at the multiple moment can be represented in the form of performance graph.For example, the scan data at multiple moment PET curves A can be expressed as.The PET curves A can be standard intake (Standardized Uptake Value, SUV the curve for) changing over time.The standard intake can be related to the metabolism of scanning area interimage agent.In some realities Apply in example, the standard intake can be used for judging the metaboilic level of scanning area inner tissue.For example, different in same organs The height of the standard intake at position can be used for judging the metaboilic level of the different parts.In certain embodiments, it is pernicious The standard intake of tumor tissues is higher than benign tumour.

In 810 and 811, scan module 310 can gather PET data B and PET data C in respective regions respectively.Example Such as, scan module 310 can gather heart dynamic PET data B and belly dynamic PET data C.In certain embodiments, 810 He The operation that 811 operations for being included can be included with 809 is same or similar.In certain embodiments, in 809,810 and 812 Operation can carry out simultaneously.For example, the sweep parameter that scan module 310 can be based respectively on setting in 806,807 and 808 is same When collection brain, the dynamic data of heart and belly.

It should be noted that description of the above for the process of acquisition PET scan data, only for convenience of description, can not The application is limited within the scope of illustrated embodiment.It is appreciated that for a person skilled in the art, understanding the stream Cheng Hou, may be exchanged or be combined in the case of without departing substantially from this principle to each step, to implementing above-mentioned side Various amendments and change in method and systematic difference field form and details.For example, PET scan unit 1, PET scan unit 2 There can be different structures with PET scan unit 3, and/or based on different sweep parameters respectively to brain, heart and belly It is scanned, and obtains the dynamic scan data of corresponding site simultaneously.

Fig. 9 is the flow chart of the illustrative methods based on the PET scan data that acquisition is processed in the application some embodiments. In certain embodiments, 900 operations for being included can be realized by the scan module described by the application other parts, example Such as, the scan module 310 described by Fig. 3, the scan module 500 described by Fig. 5, the scan module 700, Figure 10 described by Fig. 7 Described scan module 1000, the scan module 1100 described by Figure 11, the scan module 1200, Tu13Suo described by Figure 12 Scan module 1300 of description etc..In 901, imaging system 100 gathers the PET numbers of respective regions using PET scan unit 921 According to A (such as brain dynamic data).In certain embodiments, 901 operations for being included can with flow 800 in 809 included Operation is same or similar.

In 902 and 903, scan module 310 can respectively gather PET data B (for example, heart dynamic data) and PET Data C (for example, belly dynamic data).In certain embodiments, 902 and 903 operations for being included can be included with 901 Operation is same or similar.In certain embodiments, the operation in 901,902 and 903 can be carried out simultaneously, such as scan module 310 dynamic datas that can simultaneously gather brain, heart and belly.

In 904, scan module 310 can obtain intersection and meet data D.In certain embodiments, the intersection meets Data D can be based on the photon pair launched in the tissue of position between PET scan unit 921 and PET scan unit 922 and produce. The photon by PET scan unit 921 and PET scan unit 922 to that can be obtained respectively.In certain embodiments, the friendship Fork meets data D can jointly be produced by PET scan unit 921 and PET units 922.In certain embodiments, it is described to intersect symbol Closing data D can be sent to image-forming module 330.Image-forming module 330 can be by one or more processing method to the friendship Fork meets data and is processed.For example, image-forming module 330 can be screened to the data D that meets for obtaining, launch angle is removed More than the photon pair of certain threshold value.Again for example, image-forming module 330 can be multiplied by one between 0 and 1 to the data D that meets for obtaining Between weight coefficient.The weight coefficient can be with the distance between PET scan unit 921 and PET scan unit 922 phase Close.

In 905, scan module 310 can obtain intersection and meet data E.In certain embodiments, 905 behaviour for being included The operation that work can be included with 904 is same or similar.In certain embodiments, the operation in 904 and 905 can enter simultaneously OK.

In 906, image-forming module 330 can be based on PET data A (for example, brain dynamic data), rebuild respective regions PET image (for example, brain PET scan image).Image-forming module 330 can be carried out by one or more reconstruction technique to brain Imaging.The reconstruction technique can be including filter back-projection reconstruction algorithm, iterative reconstruction algorithm etc..As an example, iterative approximation Algorithm includes maximum likelihood-expectation maximization method (Maximum Likelihood-Expectation Maximum), conjugation ladder Degree method (Conjugate gradient), MAP estimation method (Maximum A Posteriori) etc..In some implementations In example, image-forming module 330 can be processed the image after reconstruction by one or more post-processing technology.The post processing Technology can be including image enhaucament, image geometry treatment, image denoising, image characteristics extraction etc..As an example, described image increases Histogram enhancement, virtual color display, greylevel window enhancing etc. can be included by force.Described image geometric manipulations can contract including image Put, distortion correction, skew control, areal calculation etc..Described image denoising can be including filtering, edge regularization etc..Image is special Levying extraction can include the extraction to picture edge characteristic, the extraction to image texture characteristic, the extraction to picture shape feature And the extraction to image outline feature etc..

In 907-910, image-forming module 330 can be based on PET scan data D, PET scan data B, PET scan data E, PET scan data C are respectively to corresponding position (for example, position, cardia, heart and belly between brain and heart Between position and belly) carry out image reconstruction.In certain embodiments, the image reconstruction algorithm employed in 906-910 Can be with identical or different.In certain embodiments, image-forming module 330 can select corresponding algorithm for reconstructing according to imaging position. For example, image-forming module 330 can use different algorithm for reconstructing, image reconstruction is scanned to brain and cardia.

In 911, image-forming module 330 can carry out fusion treatment to the image rebuild in one or more 906-910.Institute Stating fusion treatment can be including image registration, image co-registration, post processing of image etc..Image registration can carry out several to described image The operation such as what correction, projective transformation, common scale chi.The method of image registration can be including phase correlation method, based on time domain Method etc..In certain embodiments, image-forming module 330 can carry out the registration of multiple images by way of drawing position line. The position line can include the positional information and registering relation between multiple images.In certain embodiments, the position line Can automatically be drawn with default behavior by image-forming module 330, by user's hand drawn, or image-forming module 330 is according to real image It is automatic to draw.In certain embodiments, image-forming module 330 can be based on the encoded radio drafting position line of each image.Image co-registration Pixel-level fusion, feature-based fusion and decision level fusion can be included.Post processing of image can include that contrast adjustment, brightness are adjusted Section, soft treatment, smoothing processing etc..In certain embodiments, user can be based on spliced image selection one or more Post-processing approach, for the difference of balanced stitching portion.

In certain embodiments, the whole region that PET scan unit 921-923 can be simultaneously to patient's brain to belly is entered Row scanning, and based on scan data A-E, rebuild the scan image in each region.The scan image in each region can be spliced into Patient's brain to belly overall PET scan image.

Figure 10 is based on a schematic diagram for sample scan module in the application some embodiments.Scan module 1000 can be with Including 1010, three PET scan unit 1021-1023 of a CT scan unit, one scanning bed 1030 and a drive device 1050.Scanning bed 1030 can support patient 1040.In scanning process, scanning bed 1030 bed board can be put down vertically Move.In certain embodiments, drive device 1050 can drive CT scan unit 1010 to be scanned patient 1040, and obtain Scan data.After completing the CT scan, image-forming module 330 can be based on the scan data generation that CT scan unit 1010 is obtained CT spacers (such as the CT spacers 1060 of the example shown in Figure 10).

Based on CT spacers, control module 320 can determine PET scan unit 1021, PET scan unit 1022 and PET The scan position of scanning element 1023.In certain embodiments, control module 320 determines the specific reality of the PET scan position The mode of applying may refer to the application other parts, such as Fig. 5,6,7 or 8 and its description.In certain embodiments, PET scan unit 1021st, the region of PET scan unit 1022 and the scanning of PET scan unit 1023 can be respectively 1060-1,1060-2 and 1060- 3.In some implementation illustrations, there is PET scan unit 1021,1022 and 1023 identical or different axially or radially scanning to regard It is wild.Correspondingly, the size of scanning area 1060-1,1060-2 and 1060-3 can be with identical or different.In certain embodiments, sweep It can be close-connected region to retouch region 1060-1,1060-2 and 1060-3.

Drive device 1050 can respectively drive PET scan unit 1021, PET scan unit 1022 and PET scan unit 1023 are respectively moved to corresponding position, and respective regions are scanned.In certain embodiments, PET scan unit 1021, PET scan unit 1022 and PET scan unit 1023 can be scanned to the region simultaneously, and obtain PET dynamic scans Data.Based on the scan data of PET scan unit 1021-1023, image-forming module 330 can respectively generate scanning area 1060- 1st, the PET scan image of 1060-2 and 1060-3.The PET image in each region can be spliced into one by image-forming module 330 Complete scanning area.

The description to scan module is only some specific embodiments above, is not considered as only feasible program. For clearly for one of skill in the art, after the general principle for understanding invention description, may be without departing substantially from this principle In the case of, the configuration to imaging scanner carries out various amendments and change.But these amendments and change are still in above description In the range of.For example, scan module 1000 can include any number of PET scan unit.Any number of PET scan Unit can be scanned to multiple regions being connected with each other, and obtain scan data.Image-forming module 330 can be by based on described Scan data, rebuilds the PET scan image in each region.In certain embodiments, image-forming module 330 can be to the scanning in each region Image is spliced, and generates an image for larger field range.

Figure 11 is based on a schematic diagram for sample scan module in the application some embodiments.Scan module 1100 can be with Including 1110, two PET scan units of a CT scan unit 1121 and 1122, scanning bed 1130 and a drive device 1150.Scanning bed 1130 can support patient 1140.In scanning process, scanning bed 1130 bed board can be axially moveable. Drive device 1150 can drive CT scan unit 1110 to be scanned patient, and generate CT spacers.It is fixed based on the CT Bit slice, control module 320 can control drive device 1150, drive PET scan unit 1121 and PET scan unit 1122 to distinguish Specified location (for example, the position corresponding to the cardia 1140-2 and head 1140-1 of patient 1140) is moved to, is swept Retouch imaging.

PET scan unit 1121 can be differently configured from PET scan unit 1122.In certain embodiments, PET scan unit 1121 compared with PET scan unit 1122, the detector rings can with different-diameter or different in width, and/or different shape, Varying number or different types of detecting element.In certain embodiments, PET scan unit 1121 and PET scan unit 1122 Compare, the diameter of its detector rings is different.For example, PET scan unit 1121 can include one or more larger-diameter spies Device ring is surveyed, for being scanned to the cardia 1140-2 of patient 1040.PET scan unit 1122 can include one or more The detector rings of small diameter, for being scanned to the head 1140-1 of patient 1040.In certain embodiments, swept for PET Unit 1121 and PET scan unit 1122 are retouched, imaging system 100 can be respectively provided with different sweep parameter, data storage sides Formula and/or method for reconstructing.In certain embodiments, PET scan unit 1121 and PET scan unit 1122 can be simultaneously to described Region is scanned, and obtains PET dynamic scan data.In certain embodiments, image-forming module 330 can be based on the scanning Data, rebuild the PET scan image of the corresponding scanning area of the scan position.In some implementation illustrations, PET scan unit 1121 and 1122 can have identical or different axially or radially scan vision.In certain embodiments, PET scan unit At least one of 1121 and 1122 can maintain static.Drive device 1150 can drive remaining another PET scan unit It is axially moveable.For example, PET scan unit 1122 can be scanned with axial restraint to patients head；Drive device 1150 can To drive PET scan unit 1121 to be axially moveable, to patient's trunk, four limbs etc., other positions are scanned.

The description to scan module is only some specific embodiments above, is not considered as only feasible program. For clearly for one of skill in the art, after the general principle for understanding invention description, may be without departing substantially from this principle In the case of, the configuration to imaging scanner carries out various amendments and change.But these amendments and change are still in above description In the range of.For example, scan module 310 may further include one or more particular designs for being carried out to privileged site The PET scan unit of scanning imagery, for example, the position such as four limbs, neck to patient is scanned the PET scan unit of imaging.

Figure 12 is based on a schematic diagram for sample scan module in the application some embodiments.Scan module 1200 can be with Including two PET scan units 1221 and 1222, scanning bed 1250 and a drive device 1260.Scanning bed 1250 can be with Support patient 1240.In scanning process, scanning bed 1250 bed board can be maintained static.Drive device 1260 drives PET scan Unit 1221 and PET scan unit 1222 are axially moveable to specified PET scan position, are scanned imaging.In some realities Illustration is applied, PET scan unit 1221 and 1222 there can be identical or different axially or radially scan vision.In some implementations In example, at least one of PET scan unit 1221 and 1222 can be maintained static.Drive device 1260 can drive another PET scan unit is axially moveable.For example, PET scan unit 1122 can be scanned with axial restraint to patients head；Drive Dynamic device 1260 can drive PET scan unit 1221 to be axially moveable, and to patient's trunk, four limbs etc., other positions are swept Retouch.

In certain embodiments, the PET scan position can be determined by user.For example, working as the body needed to patient When a part carries out PET scan, doctor according to the illness of patient and build, can judge the position at the position of needs scanning. In some embodiments, doctor can drive PET scan unit 1221 and PET scan unit by controlling drive device 1260 1222 are moved to corresponding position.For example, doctor may determine that the general location of head 1240-2 and liver region 1240-1, and It is determined that corresponding to the bed code value of the site location.After control module 320 receives the bed code value of doctor's input, can be with root According to the bed code value, corresponding control drive device 1260 moves PET scan unit 1221 and PET scan unit 1222 respectively To corresponding position, PET scan is carried out to corresponding site 1240-1 and 1240-2.Again for example, doctor can be input into patient 1240 Height values.Based on the height values, control module 320 can determine patients head and liver region relative to its foot away from From with the bed code value of this determination PET scan position.In certain embodiments, the distance can be counted based on big data Average value, median for arriving etc..The distance can by network or be connected to network database or server obtain.It is based on The bed code value, control module 320 can control drive device 1260 to move PET scan unit 1221 and PET scan unit 1222 to corresponding position.In certain embodiments, PET scan unit 1221 and PET scan unit 1222 can be simultaneously to institutes Rheme is put corresponding region and is scanned, and obtains PET dynamic scan data.In certain embodiments, image-forming module 330 can be with Based on the scan data, the PET scan image of the scan position correspondence scanning area is rebuild.

In certain embodiments, imaging scanner 1200 may further include an imageing sensor, such as camera Or camera.Described image sensor can be installed on the top of patient, the image for gathering patient.In some embodiments In, described image may be used to determine whether the information such as the height of patient, parts of body ratio.Based on described information, mould is controlled Block 320 can determine the position at position to be scanned, and control drive device 1260, drive PET scan unit 1221 and PET scan Unit 1222 is moved to corresponding position.

Figure 13 is based on a schematic diagram for sample scan module in the application some embodiments.Scan module 1300 can be with Including two PET scan units 1321 and 1322, scanning bed 1350 and a drive device 1360.Scanning bed 1250 can be with Support patient 1240.In scanning process, scanning bed 1250 bed board can be maintained static.Control module 320 can control to drive Device 1360, drives PET scan unit 1321 and PET scan unit 1322 to be axially moveable to specified PET scan position, enters Row scanning imagery.In certain embodiments, control module 320 determines that the specific embodiment of the PET scan position can join See the application other parts, such as Figure 12 and its description.In some implementation illustrations, PET scan unit 1321 and 1322 can have Identical or different axially or radially scan vision.In certain embodiments, at least in PET scan unit 1321 and 1322 It is individual to maintain static.Drive device 1360 can drive another PET scan unit to be axially moveable.For example, PET scan list Unit 1322 can be scanned with axial restraint to patients head；Drive device 1360 can drive PET scan unit 1321 along axle To movement, to patient's trunk, four limbs etc., other positions are scanned.

As shown in FIG., PET scan unit 1321 and PET scan unit 1322 can respectively to renal tract 1340-3 and Head 1340-1 is scanned.Scan data based on PET scan unit 1321 and PET scan unit 1322, image-forming module 330 The PET image of corresponding site can be generated.In certain embodiments, scan module 310 can gather cardia 1340-2's Scan data.The scan data can jointly be obtained by PET scan unit 1321 and PET scan unit 1322.In some realities Apply in example, image-forming module 330 can meet data and be corrected to the intersection of the cardia 1340-2.For example, imaging mould Block 330 can meet data and screen to the intersection of acquisition, photon pair of the removal launch angle more than certain threshold value.And example Such as, image-forming module 330 can meet data and be totally multiplied by a weight coefficient between 0 and 1 to the intersection for obtaining.It is described Weight coefficient can be related to the distance between PET scan unit 1321 and PET scan unit 1322.Based on the intersection after correction Meet data, image-forming module 330 can rebuild the PET image of cardia.In certain embodiments, PET scan unit 1121 Above three region can be scanned simultaneously with PET scan unit 1122, and obtain PET dynamic scan data.At some In embodiment, image-forming module 330 can be based on the scan data, rebuild the overall PET scan image in the region.

Basic conception is described above, it is clear that to those skilled in the art, foregoing invention is disclosed only As an example, and not constituting the restriction to the application.Although do not clearly state herein, those skilled in the art may Various modifications, improvement and amendment are carried out to the application.Such modification, improvement and amendment are proposed in this application, so such Change, improve, correct the spirit and scope for still falling within the application example embodiment.

Meanwhile, the application describes embodiments herein using particular words.Such as " one embodiment ", " one implements Example ", and/or " some embodiments " mean a certain feature related to the embodiment of the application at least one, structure or feature.Cause This, it should be highlighted that and it is noted that " embodiment " or " implementation that are referred to twice or repeatedly in diverse location in this specification Example " or " alternate embodiment " are not necessarily meant to refer to same embodiment.Additionally, in one or more embodiments of the application Some features, structure or feature can carry out appropriate combination.

Additionally, it will be understood by those skilled in the art that each side of the application can be by some with patentability Species or situation are illustrated and described, including any new and useful operation, machine, product or material combination, it is or right Their any new and useful improvement.Correspondingly, the various aspects of the application can completely by hardware perform, can be complete Performed by software (including firmware, resident software, microcode etc.), can also be performed by combination of hardware.Hardware above is soft Part is referred to alternatively as " data block ", " module ", " engine ", " unit ", " component " or " system ".Additionally, each side of the application The computer product being located in one or more computer-readable mediums may be shown as, the product includes computer-readable program Coding.

Computer program code needed for the operation of the application each several part can use any one or more programming language, Including Object-Oriented Programming Language such as Java, Scala, Smalltalk, Eiffel, JADE, Emerald, C++, C#, VB.NET, Python etc., conventional procedural programming language for example C language, Visual Basic, Fortran 2003, Perl, COBOL 2002, PHP, ABAP, dynamic programming language such as Python, Ruby and Groovy, or other programming languages etc..The program coding can be with complete It is complete to run on the user computer or run on the user computer as independent software kit or part is in subscriber computer Run on remote computer or server in remote computer operation or completely upper operation part.In the latter cases, remotely Computer can be connected by any latticed form with subscriber computer, such as LAN (LAN) or wide area network (WAN), or even Outer computer (such as by internet) is connected to, or in cloud computing environment, or it is service to use software such as service (SaaS)。

Additionally, except clearly stating in non-claimed, the order of herein described processing element and sequence, digital alphabet Using or other titles use, be not intended to limit the order of the application flow and method.Although by each in above-mentioned disclosure Kind of example discusses some it is now recognized that useful inventive embodiments, but it is to be understood that, such details only plays explanation Purpose, appended claims are not limited in the embodiment for disclosing, conversely, claim is intended to, and covering is all to meet the application The amendment of embodiment spirit and scope and equivalent combinations.For example, although system component described above can be set by hardware It is standby to realize, but only can also be achieved by the solution of software, pacify such as on existing server or mobile device The described system of dress.

Similarly, it is noted that in order to simplify herein disclosed statement, so as to help real to one or more inventions Apply the understanding of example, above to the description of the embodiment of the present application in, sometimes by various features merger to one embodiment, accompanying drawing or In descriptions thereof.But, this disclosure method be not meant to the application object required for aspect ratio claim in carry And feature it is many.In fact, the feature of embodiment will be less than whole features of the single embodiment of above-mentioned disclosure.

Description composition, the numeral of number of attributes are used in some embodiments, it should be appreciated that such for embodiment The numeral of description, has used qualifier " about ", " approximate " or " generally " to modify in some instances.Unless said in addition Bright, " about ", " approximate " or " generally " shows that the numeral allows ± 20% change.Correspondingly, in some embodiments In, the numerical parameter used in description and claims is approximation, approximation feature according to needed for separate embodiment Can change.In certain embodiments, numerical parameter is considered as the significant digit of regulation and using the reservation of general digit Method.Although for confirming the Numerical Range and parameter of its scope range being approximation in the application some embodiments, specific real Apply in example, being set in for such numerical value is reported as precisely as possible in feasible region.

Each patent, patent application, patent application publication thing and the other materials quoted for the application, such as article, book , be incorporated herein entire contents as reference hereby by nationality, specification, publication, document, object etc..With teachings herein It is (current to the conditional file of the application claim widest scope except application history file that is inconsistent or producing conflict Or be additional in the application afterwards) also except.If it should be noted that description, definition in the application attaching material, And/or the use of term with it is herein described it is interior have place that is inconsistent or conflicting, with the description of the present application, definition and/or The use of term is defined.

Finally, it will be understood that embodiment described herein is only used to illustrate the principle of the embodiment of the present application.Other Deformation be likely to belong to scope of the present application.Unrestricted accordingly, as example, the alternative configuration of the embodiment of the present application is visual It is consistent with teachings of the present application.Correspondingly, embodiments herein is not limited only to the implementation that the application is clearly introduced and described Example.

Claims

1. a kind of medical image system, it is characterised in that including：

Imaging scanner, including：

First PET scan unit, the second PET scan unit, and

Drive device；And

Computer equipment, including：

Controller, determines the first scan position and the second scan position, and

Processor, wherein,

The drive device can drive the first PET scan unit and the second PET scan unit to be respectively moved to described first Scan position and the second scan position,

The first PET scan unit and the second PET scan unit can respectively obtain first scan data and one second Scan data, and

The processor can be based on first scan data and the second scan data, corresponding to first scan position the One scan region and corresponding second scanning area of second scan position are imaged.

2. system according to claim 1, it is characterised in that the first PET scan unit includes that a PET is visited Device ring is surveyed, the second PET scan unit includes a second pet detector ring, the first pet detector ring and second Pet detector ring is compared to identical or different diameter.

3. system according to claim 1, it is characterised in that the first PET scan unit and the second PET scan unit In the drive device, the drive device can drive the first PET scan unit and the second PET scan unit edge Axial movement.

4. system according to claim 1, it is characterised in that further include a CT scan unit, the CT scan Unit obtains CT scan data, and based on the CT scan data, the processor generates a positioning image.

5. system according to claim 4, it is characterised in that the positioning image includes one first mark and the Two mark, the controller by obtain it is described first mark and second mark position, determine first scan position and Second scan position.

6. system according to claim 1, it is characterised in that the controller can be by obtaining first scan position With the second scan position, it is determined that driving the distance of the first PET scan unit and the movement of the second PET scan unit.

7. system according to claim 1, it is characterised in that further include an imageing sensor, described image is passed Sensor produces view data, and the controller is based on described image data, determines that first scan position and described second is swept Retouch position.

8. system according to claim 1, it is characterised in that the first PET scan unit and the second PET scan unit First scan data and the second scan data at multiple moment can be respectively obtained, the processor can be based on the multiple moment First scan data and the second scan data, dynamic imaging is carried out to first scanning area and the second scanning area.

9. system according to claim 8, it is characterised in that the processor can be based on the dynamic imaging, determine institute The metabolism of contrast agent in the first scanning area and the second scanning area is stated, the metabolism is changed over time.

10. system according to claim 1, it is characterised in that the processor can based on first scan data and Second scan data is imaged to first scanning area and the second scanning area simultaneously.

11. systems according to claim 1, it is characterised in that the processor can be based on the first PET scan unit The 3rd scan data obtained with the second PET scan unit is imaged to the 3rd scanning area, the 3rd scanning number Obtained jointly according to by the first PET scan unit and the second PET scan unit, the 3rd scanning area is between described first Between scanning area and second scanning area.

12. systems according to claim 11, it is characterised in that the processor can be based on the first PET scan list The scan data that unit and the second PET scan unit are obtained is to first scanning area, the second scanning area and the 3rd scanning area Domain is imaged respectively, and is a complete image by the image mosaic of acquisition.

13. systems according to claim 1, it is characterised in that

The first PET scan unit obtains the first sweep parameter, according to first sweep parameter for obtaining, scans described the One scan region；And

The second PET scan unit obtains the second sweep parameter, according to second sweep parameter for obtaining, scans described the Two scanning areas, wherein, first sweep parameter and second sweep parameter are similar and different.

14. systems according to claim 1, it is characterised in that

The processor obtains the first imaging parameters, according to the first imaging parameters for obtaining, first scanning area is imaged； And

The processor obtains the second imaging parameters, according to second imaging parameters for obtaining, to second scanning area Imaging, wherein, first imaging parameters and the second imaging parameters are similar and different.

System described in 15. claims 1, the axially or radially scan vision of the second PET scan unit and described first The axially or radially scan vision of PET scan unit is similar and different.

A kind of 16. medical imaging procedures, it is characterised in that including：

Obtain the first PET scan parameter for the first PET scan unit and the 2nd PET for the second PET scan unit sweeps Retouch parameter；

Obtain the first scan position and the second scan position；

According to the first PET scan parameter, swept using the first PET scan unit corresponding to first scan position first Retouch region to be scanned, generate the first PET scan data；

According to the second PET scan parameter, swept using the second PET scan unit corresponding to second scan position second Retouch region to be scanned, generate the second PET scan data；

First scanning area is imaged based on first PET scan data；And

Second scanning area is imaged based on second PET scan data.