CN110261627A - A kind of high-precision ovulation period prediction technique and device - Google Patents
A kind of high-precision ovulation period prediction technique and device Download PDFInfo
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Abstract
The present invention provides a kind of high-precision ovulation period prediction technique and device, pass through the scheme of the trend ovulation period of the adjacent uptake measured several times, the transformation of rapid drawdown is risen to by the calculating of uptake to judge the generation of ovulation event, reduce error caused by being converted to LH concentration in the process by uptake, and the precision of prediction of the program can be precisely to hour.
Description
Technical field
The present invention relates to ovulation tests field, in particular to a kind of high-precision ovulation period prediction technique and device.
Background technique
After follicular development maturation in female body, egg cell will eject in ovary, this process is exactly to ovulate.
The date of female ovulation is usually the fortnight or so before menstruation next time, this day is known as ovulation day.Ovulation
On the day of five days, later four days before day and ovulation day, this stage is known as the onset of ovulation, accurately knows that ovulation day can
To assist women to obtain fertility or birth control control.
Know that ovulation period mainly passes through observation leukorrhea situation, record basal body temperature, ovulation test paper detection and B at present
Super to monitor these types of mode, wherein ovulation test paper detection is a kind of mode of most convenient, and this method needs survey in continuous more days
Examination determines ovulation period by interstitialcellstimulating hormone (ICSH) (LH) concentration in acquisition urine.Currently, relevant ovulation tests equipment is
Test paper is obtained to the uptake of light by the photosensitive sensor in it, is then substituted into formula calculating test paper and is picked in urine sample
Metakentrin concentration, then according to the relationship of ovulation period and interstitialcellstimulating hormone (ICSH) (LH) concentration infer ovulation period.
And this mode major defect be it is as follows:
1, due to the limitation of test paper production technology, there are inconsistency (batch internal difference), same rush corpus luteum for same batch test paper
The urine of the plain concentration of generation will appear the inconsistent phenomenon of thickness, color depth after reacting on different test paper, lead to uptake
There is certain variation.
2, since there are larger differences between distinct device, even if the same test paper of same interstitialcellstimulating hormone (ICSH) (LH) concentration
The uptake tested on different devices also has larger difference.
3: since different batches test paper otherness is larger (difference between batch), ovulation tests equipment must bind the examination of a batch
Paper, when changing other batch test paper, test paper same interstitialcellstimulating hormone (ICSH) (LH) concentration uptake variation be possible to very greatly and
Lutropin (LH) concentration for causing ovulation tests equipment to be calculated has relatively large deviation that ovulation period is caused to infer inaccuracy.
Prior art CN108333377A provides a kind of value added by measuring unit time LH concentration, according to LH peak value
Size calculate LH and reach time of peak value, to calculate the mode of ovulation period, however which still needs to turn collection value
It is changed to test value and is converted to LH concentration, error certainly will be introduced during conversion, to influence testing result.And this method is surveyed
Examination be the unit time LH value added, calculated by value added and reach time of LH peak value, such calculating be it is inaccurate,
Obtained ovulation period and actual error is larger.
Summary of the invention
The purpose of the present invention is to provide a kind of high-precision ovulation period prediction technique and device, this method leads to traditional
The method migration for crossing LH concentration prediction ovulation period is to reduce uptake being converted to LH by the uptake predicting ovulation time
The process of concentration, the influence for avoiding unnecessary error from bringing test result, in addition, ovulation period can be accurate to by this method
Hour, the very big detection efficiency for improving ovulation period.
In order to realize any of the above goal of the invention, the present invention provides a kind of high-precision ovulation period prediction technique, including with
Lower step:
S1: before menstrual period, obtaining the absorbing amount of the LH test paper of at least two interval tests within the first interval time,
And the first test interval of intra-record slack byte test, the first test slope is obtained, wherein test slope is absorbing amount difference
With the ratio in the first test interval, wherein the first interval time be 2-48 hours；
S2: judging whether the first test slope meets the condition of first slope anticipation value, wherein first slope anticipation value pair
It answers LH concentration close to the state of LH peak concentration, if eligible, continues to obtain at least two interval surveys within the second interval time
The absorbing amount of the LH test paper of examination, and the second test interval of intra-record slack byte test, obtain the second test slope,
Middle test slope is the ratio of absorbing amount difference and the second test interval, wherein the second interval time was 2-12 hours；
And
S3: judging whether the second test slope meets the condition of the second slope anticipation value, wherein the second slope anticipation value pair
The state of LH concentration rapid drawdown is answered, if eligible, shows the predicting ovulation time, wherein ovulation period is that corresponding be somebody's turn to do is tested for the second time
Preceding 2-4 hours or 2-4 hours latter of the last test time of slope.
According to another aspect of the present invention, a kind of high-precision ovulation period prediction meanss, interior built-in chip load are provided
There is the high-precision ovulation period prediction technique mentioned as described above.
Compared with the prior art, the invention has the characteristics that and the utility model has the advantages that
1. directly replacing traditional LH concentration prediction ovulation period in the way of the uptake predicting ovulation time, reduce
Uptake is converted to the calculating step of LH concentration, so as to avoid the error introduced in conversion process, reduces equipment difference, examination
Influence of the paper difference to testing result.
2. reducing single test error by the trend ovulation period of the adjacent uptake tested several times
The influence of (test paper batch internal difference) to test, improves detection accuracy.
3. ovulation period can be accurate to hour by this method, and user only needs to carry out ground on the day before ovulation and one day after
Frequently test can prompt user, accurate predicting ovulation time when needing frequently test in time.
Detailed description of the invention
Fig. 1 is test paper uptake change curve, 1,3 and 4 is wherein same batch test paper in distinct device in Fig. 1
Uptake change curve, 2 and 5 be the uptake change curve of different batches test paper in same equipment.
Fig. 2 is the upper deviation, the uptake change curve of standard curve and lower deviation.
Fig. 3 A to Fig. 3 D is the error analysis signal of the uptake change curve of the upper deviation and lower deviation based on Fig. 2
Figure.
Fig. 4 is the schematic diagram of slope of standard curve variation tendency.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art's every other embodiment obtained belong to what the present invention protected
Range.
It will be understood by those skilled in the art that in exposure of the invention, term " longitudinal direction ", " transverse direction ", "upper",
The orientation of the instructions such as "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside" or position are closed
System is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of description of the present invention and simplification of the description, without referring to
Show or imply that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore above-mentioned art
Language is not considered as limiting the invention.
It is understood that term " one " is interpreted as " at least one " or " one or more ", i.e., in one embodiment,
The quantity of one element can be one, and in a further embodiment, the quantity of the element can be it is multiple, term " one " is no
It can be interpreted as the limitation to quantity.
The present invention provides a kind of high-precision ovulation period prediction technique, and this method is applied in ovulation period detection device,
Wherein ovulation period detection device is built-in with photosensitive sensor, and photosensitive sensor acquires LH reaction test paper to the uptake of light,
Traditional mode needs to be converted to uptake into LH concentration, and according to LH concentration prediction ovulation period, and the one of this method innovates greatly
Place is directly utilize collected uptake accurately predicting ovulation time.
The step of this method includes:
S1: before menstrual period, obtaining the absorbing amount of the LH test paper of at least two interval tests within the first interval time,
And the first test interval of intra-record slack byte test, the first test slope is obtained, wherein test slope is absorbing amount difference
With the ratio in the first test interval, wherein the first interval time be 2-48 hours；
S2: judging whether the first test slope meets the condition of first slope anticipation value, wherein first slope anticipation value pair
It answers LH concentration close to the state of LH peak concentration, if eligible, continues to obtain at least two interval surveys within the second interval time
The absorbing amount of the LH test paper of examination, and the second test interval of intra-record slack byte test, obtain the second test slope,
Middle test slope is the ratio of absorbing amount difference and the second test interval, wherein the second interval time was 2-12 hours；
And
S3: judging whether the second test slope meets the condition of the second slope anticipation value, wherein the second slope anticipation value pair
The state of LH concentration rapid drawdown is answered, if eligible, shows the predicting ovulation time, wherein ovulation period is that corresponding be somebody's turn to do is tested for the second time
Preceding 2-4 hours or 2-4 hours latter of the last test time of slope.
In addition, before step S3, it is another comprising steps of
S4: judging whether the second test slope meets the condition of third slope anticipation value, wherein third slope anticipation value pair
The state for answering LH to reach peak value or begun to decline continues to test.
The test philosophy of program foundation is as follows:
It is obtained by the observation analysis to LH concentration and uptake data, the concentration and test paper of interstitialcellstimulating hormone (ICSH) (LH) are inhaled
The relationship that receipts amount is positively correlated, specific manifestation are as follows: 1. when interstitialcellstimulating hormone (ICSH) (LH) concentration rapidly rises, and uptake is also anxious
Speed rises；2. uptake also generates rapid drawdown after interstitialcellstimulating hormone (ICSH) (LH) concentration reaches peak value when rapid drawdown；3. although difference is set
Difference between standby between difference and test paper different batches will lead to the uptake variation of same interstitialcellstimulating hormone (ICSH) (LH) concentration,
But the difference between distinct device between difference and test paper different batches has no effect on the variation tendency of whole cycle, test data
As shown in Figure 1,1,3 and 4 being uptake change curve of the same batch test paper in distinct device in Fig. 1,2 and 5 be same
The uptake change curve of different batches test paper in one equipment.
In the present invention, the first slope anticipation value, the acquisition side of the second slope anticipation value and third slope anticipation value
Formula is as follows: two days before and after female ovulation LH change curves being converted to uptake change curve, then at least take absorption quantitative change
Three test points changed on curve are fitted straight line, the slope of straight line are obtained, wherein the time interval 2-12 of three test points
Hour.
Specifically, first slope anticipation value takes: LH concentration soon close to peak value when section at least three test points, it is right
These three test points should be fitted to straight line, obtain slope to three test points on uptake change curve at this time.
Similarly, the second slope anticipation value takes: LH concentration takes at least three test points in LH rapid drawdown section；The anticipation of third slope
Value takes LH to reach peak value or has begun to decline at least three test points in section.
In step S1, since women can not ovulate for 10 days before menstrual period, so user is at this stage
It can not have to continually be tested, the first interval time was 2-48 hours at this time, and user may be selected to test every other day.Menstrual period may be selected
10 start to test for first 10 days.
In step S2, judge whether the first test slope meets the condition of first slope anticipation value and refer to first
Whether test slope is greater than first slope anticipation value, if more than then thinking eligible.Preferably, the second testing time was 4 small
When.
In step S3, judge whether the second test slope meets the condition of the second slope anticipation value and refer to second
Whether test slope if be less than if thinks eligible less than the second slope anticipation value, in the present solution, can be by ovulation period essence
Really to hour.
In step s 4, judge whether the second test slope meets the condition of third slope anticipation value and refer to the second survey
Whether examination slope is in the section of third slope anticipation value, thinks eligible if in section.
Refer to it is noted that when the second test slope is increasingly closer to the second slope anticipation value, it is proposed that second test when
Between it is shorter, more accurately to get ovulation period.
In one embodiment of this invention, first slope anticipation value is 6, and the second slope anticipation value is -6, and third slope is pre-
Sentencing value is -3 to 2, this data is to count big data by the applicant to obtain, and test proves the data in practical applications
The data precision obtained is high, but this is not intended as limiting.
As shown in Figures 2 and 3, it by the influence of this method application detection single test error (test paper batch internal difference), is counted
Accordingly and result is as follows:
Test paper is taken, it is identical to control other test conditions, draws the upper deviation, the uptake variation of standard curve and lower deviation
Curve is as shown in Figure 2.As shown in Figure 2, upper deviation uptake curve, standard curve and lower deviation uptake slope of a curve become
Change it is essentially identical, and it can be seen that such data substitute into formula and calculate LH concentration with a batch test paper there are when error less than normal bigger than normal,
It can cause to test LH concentration and practical LH concentration deviation is big.
And upper deviation uptake curve and lower deviation uptake curve is taken to carry out the calculating of slope variation trend, it learns and works as
When limit error generates, the scheme by the trend ovulation period of uptake is still reliable and stable.Fig. 4 is standard song
The case where slope variation trend of line.
According to another aspect of the present invention, the present invention provides a high-precision ovulation period prediction meanss, wherein the high-precision
Processing chip in ovulation period prediction meanss is loaded with the high-precision ovulation period prediction technique mentioned thereon, high-precision using this
The prediction that ovulation period prediction technique carries out ovulation period is spent, other structures are same as conventional ovulation-period detector.
It is noted that actually reducing the requirement to equipment, such as between distinct device due to the improvement of algorithm
Difference control etc., but in order to improve acquisition data it is accurate, also to meet test paper C, T line position with sensor and luminescent device
Alignment.
The present invention is not limited to above-mentioned preferred forms, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its shape or structure, it is all that there is skill identical or similar to the present application
Art scheme, is within the scope of the present invention.
Claims (9)
1. a kind of high-precision ovulation period prediction technique, which comprises the following steps:
S1: before menstrual period, the absorbing amount of the LH test paper of at least two interval tests is obtained within the first interval time, and is remembered
In first test interval of record interval test, the first test slope is obtained, wherein test slope is absorbing amount difference and the
The ratio in one test interval, wherein the first interval time was 2-48 hours；
S2: judging whether the first test slope meets the condition of first slope anticipation value, and wherein first slope anticipation value corresponds to LH
The state of concentration close to LH peak concentration continues to obtain at least two interval tests within the second interval time if eligible
The absorbing amount of LH test paper, and the second test interval of intra-record slack byte test, obtain the second test slope, wherein surveying
The ratio that slope is absorbing amount difference and the second test interval is tried, wherein the second interval time was 2-12 hours；And
S3: judging whether the second test slope meets the condition of the second slope anticipation value, wherein the second slope anticipation value corresponds to LH
The state of concentration rapid drawdown shows the predicting ovulation time if eligible, and wherein ovulation period is corresponding second of test slope
Preceding 2-4 hours of the last test time or 2-4 hours latter.
2. high-precision ovulation period prediction technique according to claim 1, which is characterized in that judge that the second test slope is
The no condition for meeting third slope anticipation value, wherein third slope anticipation value corresponds to the shape that LH reaches peak value or begun to decline
State continues to test.
3. high-precision ovulation period prediction technique according to claim 1, which is characterized in that first slope anticipation value, the
The acquisition modes of two slope anticipation values and third slope anticipation value are as follows: two days before and after female ovulation LH change curves are turned
It is changed to uptake change curve, at least takes three test points on uptake change curve to be fitted straight line, obtains straight line
Slope, wherein the time interval of three test points 2-12 hours.
4. high-precision ovulation period prediction technique according to claim 1, which is characterized in that judge that the first test slope is
The no condition for meeting first slope anticipation value refers to whether the first test slope is greater than first slope anticipation value, if more than then
Think eligible；Judge whether the second test slope meets the condition of the second slope anticipation value and refer to the second test slope
Whether less than the second slope anticipation value, think eligible if being less than.
5. high-precision ovulation period prediction technique according to claim 2, which is characterized in that judge that the second test slope is
The no condition for meeting third slope anticipation value refers to whether the second test slope is in the section of third slope anticipation value,
Think if in section eligible.
6. high-precision ovulation period prediction technique according to claim 1, which is characterized in that when the second test slope is more next
When closer to the second slope anticipation value, the second testing time is shorter.
7. high-precision ovulation period prediction technique according to claim 1, which is characterized in that the second testing time was 4 small
When.
8. high-precision ovulation period prediction technique according to claim 1, which is characterized in that first slope anticipation value is 6,
Second slope anticipation value is -6, and third slope anticipation value is -3 to 2.
9. a kind of high-precision ovulation period prediction meanss, which is characterized in that the built-in chip in it is loaded with claim 1 as above
To 8 any high-precision ovulation period prediction techniques mentioned.
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