CN110261591A - A kind of Full-automatic universal analysis system - Google Patents
A kind of Full-automatic universal analysis system Download PDFInfo
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- CN110261591A CN110261591A CN201910606062.XA CN201910606062A CN110261591A CN 110261591 A CN110261591 A CN 110261591A CN 201910606062 A CN201910606062 A CN 201910606062A CN 110261591 A CN110261591 A CN 110261591A
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- 238000004458 analytical method Methods 0.000 title claims abstract description 17
- 239000007790 solid phase Substances 0.000 claims abstract description 271
- 238000004140 cleaning Methods 0.000 claims abstract description 149
- 238000012360 testing method Methods 0.000 claims abstract description 108
- 238000011534 incubation Methods 0.000 claims abstract description 23
- 238000001514 detection method Methods 0.000 claims abstract description 20
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 15
- 239000012491 analyte Substances 0.000 claims abstract description 10
- 230000032258 transport Effects 0.000 claims description 31
- 238000005259 measurement Methods 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 9
- 239000006210 lotion Substances 0.000 claims description 8
- 230000007704 transition Effects 0.000 claims description 6
- 230000003993 interaction Effects 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 38
- 238000000034 method Methods 0.000 abstract description 12
- 239000012071 phase Substances 0.000 abstract description 10
- 230000004044 response Effects 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 3
- 238000011049 filling Methods 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 239000003446 ligand Substances 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- -1 antibody Proteins 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000036632 reaction speed Effects 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 230000002000 scavenging effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003541 multi-stage reaction Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- 238000012545 processing Methods 0.000 description 1
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- 230000002269 spontaneous effect Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
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Abstract
The present invention provides a kind of Full-automatic universal analysis systems, it is measured for analyte qualitative, quantitative, the Full-automatic universal analysis system includes solid phase unit, solid phase unit memory module, sample storage module, reagent memory module, raising module, cleaning module, measure module and transhipment module, raising module includes that at least one set of solid phase unit for accommodating differential responses stage solid phase unit accommodates position, it includes newly being loaded position and to test sample position that every group of solid phase unit, which accommodates position, one group of solid phase unit in the differential responses stage can carry out simultaneously incubation reaction on raising module, and cleaning module is transferred to by transhipment module while being cleaned, on the one hand single sample sequence detection is realized, each sample process is consistent, testing result is more acurrate；On the other hand, the solid phase unit that each group is in different phase can be realized while be incubated for and clean simultaneously, and detection efficiency is improved.
Description
Technical field
The present invention relates to immunoassay fields, in particular to a kind of Full-automatic universal analysis system.
Background technique
The phenomenon that specificity ligand specificity spontaneous combination, the immunoassay and nucleic acid reacted such as antigen and antibody specific
The foranalysis of nucleic acids method of base pair complementarity is widely used in multiple fields.
Common immunoassay such as ELISA or board-like chemiluminescence.Design of this kind of technology based on microwell plate, with one
The relevant antigen of kind analyte or antibody are fixed in micropore, are used together with the antigen or antibody of liquid to analyze liquid-like
One of this analyte.In use, user is using micropore grillage as supporting body, micropore or make with whole plate or with single combination
With by incubation (antigen-antibody reaction), separation (washing) multiple steps finally obtain the same analyte of multiple samples
Testing result.
However above-mentioned analyzed sample is singly to be added, if sample size is few, when being added required for sample
Between can be ignored, but if the quantity of sample increases, first sample is to a last sample if the amount of sample is 100
Time interval will be more than 10 minutes.This mode is particularly with those test methods based on competition principle.It is this " simultaneously
The meaning of processing " is only left to reduce the amount of labour of user, for accurately measuring nocuousness without benefit, with adding for sample size
Greatly, the deviation of measurement result will increase.
Therefore for the accuracy of detection, ideal state is each of the result measurement from sample-adding to the end
The condition of step, which is able to maintain consistent or difference with the switch instant between step, to be ignored.However multistep is incubated for, cleaning separation
The time that detection will be increased with tens of hundreds of sample measures, severely impact the real acceptance of this perfect condition.
Other automatic analytical systems automatically divide such as utility model patent CN208092069U although can be realized
Analysis, but one index of detection is loaded, be incubated for, cleaned and detected every time and be only capable of using single reaction cup, it cannot be complete simultaneously
At the test of multiple indexs, detection efficiency is low.
Summary of the invention
To solve the above problems, the present invention provides a kind of Full-automatic universal analysis system, including solid phase unit, solid phase unit
Memory module, sample storage module, reagent memory module, raising module, cleaning module, measurement module, raising module include extremely
The solid phase unit of few each step stage of reaction solid phase unit of one group of receiving accommodates position, and it includes new sample-adding position that every group of solid phase unit, which accommodates position,
With to test sample position.
In some preferred modes, every group of solid phase unit of raising module accommodates position containing N1 aligned solid phases
Unit accommodates position, and wherein N1=3n or 2n, n are integer, and every group of solid phase unit accommodates the n new sample-adding positions that position includes point column both ends
With n to test sample position.Since the differential responses stage is both needed to carry out incubation and cleaning step, in this way consolidating in each step stage of reaction
Phase element is incubated for and is cleaned simultaneously as unit of group, is compared each stage of reaction and is individually incubated for and cleans, determination efficiency can
It is improved with twice or three times.
In some preferred modes, n=1 or 2 or 3.Influence in view of loading time to Accurate Determining is loaded every time
Solid phase element number should not be excessive, newly-increased 1 or 2 or 3 solid phase units are guaranteeing that testing result is accurately basic every time
On, further increase the efficiency of detection.
In some preferred modes, raising module solid phase unit accommodates hyte number N2=T/t, and wherein T is solid phase unit
It is one group solid that raising module solid phase unit, which is added, and accommodates position to raising module solid phase unit receiving bit interval duration, t are added again
Phase element moves into raising module solid phase unit and accommodates position to next group of solid phase unit immigration raising module solid phase unit receiving interdigit
Every duration.Since incubation reaction duration compares transhipment of the solid phase unit between raising module and cleaning module and in cleaning module
Cleaning duration to grow, by the way that T/t group solid phase unit is arranged, one group of solid phase unit may make to complete cleaning and is transported to again
After raising module, next group of solid phase unit completes incubation reaction, can carry out cleaning operation, until last group, and circuit sequentially.
Due between group and group N-free diet method be connected or the linking of very short time, save the entire detection process time, greatly improve detection
Efficiency.
In some preferred modes, raising module includes that long slab shape incubates disk, and at least one set of solid phase unit accommodates position edge
Length direction is arranged in parallel thereon.Each group solid phase unit is parallel to long slab shape and incubates on disk length direction, raising module
Features simple structure, convenient for the transhipment of each group solid phase unit.
In some preferred modes, the raising module includes that disc incubates disk, and at least one set of solid phase unit accommodates
Position arranges thereon along circumferential direction, incubates pan bottom and is provided with rotating device, and incubating disk cover body and having makes one group of solid phase unit
The opening of exposing.It is driven by rotating device and incubates disk rotation, and lid is motionless, so that different group solid phase units are successively outer
It is exposed to lid opening, convenient for the crawl and transhipment of solid phase unit.Disk is incubated using disc and rotating device is set, can be reduced
The cavity space between disk and lid is incubated, stable incubation reaction environment is conducive to provide.
In some preferred modes, every group of solid phase unit accommodates the midpoint of position line and the line in the center of circle and every group of solid phase
It is vertical that unit accommodates position line.In other preferred modes, every group of solid phase unit accommodates the extended line of position line by circle
The heart.
In some preferred modes, the system also includes transhipment module, the transhipment module includes new sample-adding transhipment
Module, transports module, the first handgrip, the second handgrip, third handgrip to test sample at cleaning transhipment module, and the new sample-adding transports mould
Block includes that N3 solid phase unit is newly loaded position, wherein N3=n；It is described to include N4 solid phase unit sample to be measured to test sample transhipment module
Position, wherein N4=n.Module is transported for solid phase unit in solid phase unit memory module, raising module, cleaning module and measurement mould
Transhipment between block, in new sample-adding transhipment module, cleaning transhipment module, to test sample transhipment module, the first handgrip, the second handgrip, the
Under the collective effect of three handgrips, realize that solid phase unit in the automatic transhipment of intermodule, improves detection efficiency.
In some preferred modes, the cleaning transhipment module includes that one group of N5 aligned solid phase unit holds
Receive position, wherein N5=N1, namely cleaning transhipment module solid phase unit accommodates the one group of solid phase unit in position and raising module and accommodates digit
Measure identical, it includes the n solid phase unit sample position to be measured positioned at one end that solid phase unit, which accommodates position,.
New sample-adding transhipment module is located along the same line with cleaning transhipment module, has convenient for solid along straight reciprocating motion
Phase element is transferred to the position I of new sample-adding transhipment module from solid phase unit memory module, convenient for the position II of sample-adding and convenient for solid
Phase element is newly loaded the position III that bit transition is newly loaded to raising module position from new sample-adding transhipment module, when being located at position III, newly
Sample-adding transhipment module, which is newly loaded position and is newly loaded bit parallel with raising module, to be aligned.
Cleaning transhipment module has along straight reciprocating motion and is transferred to cleaning transhipment mould from raising module convenient for solid phase unit
The first position of block waits for being transferred on test sample position and waits for test sample position to test sample transhipment module convenient for solid phase unit from cleaning transhipment module
On the second position and be transferred to the third place of raising module, cleaning transhipment module from cleaning transhipment module convenient for solid phase unit
When positioned at first position, cleaning transhipment module waits for that test sample position waits for that test sample bit parallel is aligned with raising module；Cleaning transhipment module position
When the second position, cleaning transhipment module waits for that test sample position waits for that test sample bit parallel is aligned with to test sample transhipment module；Cleaning transhipment mould
When block is located at the third place, cleaning transhipment module is immediately adjacent to the new sample-adding transhipment module of position III.
First handgrip transports intermodule straight reciprocating motion in solid phase unit memory module and new sample-adding, for that will consolidate
Phase element is transferred to new sample-adding transhipment module from solid phase unit memory module and is newly loaded on position；Second handgrip is being incubated for mould
Block, cleaning transhipment module and new sample-adding transhipment intermodule move back and forth, for solid phase unit on raising module to be transferred to cleaning
The solid phase unit on solid phase unit and cleaning transhipment module being newly loaded on position in transhipment module and by new sample-adding transhipment module
It is transferred to raising module；The third handgrip is transporting module and cleaning transhipment intermodule reciprocating motion to test sample, and being used for will be clear
It washes the solid phase unit that transhipment module waits on test sample position and is transferred to and waited on test sample position to test sample transhipment module.
By being newly loaded transhipment module, cleaning transhipment module, to the cooperation and first of test sample transhipment block motion and position
The transferance of handgrip, the second handgrip, third handgrip realizes solid phase unit in raising module by being newly loaded position to test sample position
Displacement, realize the single full-automatic tested in sequence of solid phase unit, improve detection efficiency on the basis of improving detection accuracy.
In some preferred modes, the cleaning transhipment module includes that one group of N5 aligned solid phase unit holds
Receive position, wherein N5=N1+n, it includes that the n solid phase unit positioned at both ends is newly loaded position and n solid single that solid phase unit, which accommodates position,
Member is to test sample.
New sample-adding transhipment module has and is transferred to convenient for solid phase unit from solid phase unit memory module along straight reciprocating motion
The position I of new sample-adding transhipment module is newly loaded position from new sample-adding transhipment module convenient for the position II of sample-adding and convenient for solid phase unit
It is transferred to the position III that cleaning transhipment module is newly loaded position, when being located at position III, new sample-adding transhipment module is newly loaded position and cleaning
Transhipment module is newly loaded bit parallel alignment.
Cleaning transhipment module has along straight reciprocating motion and is transferred to cleaning transhipment mould from raising module convenient for solid phase unit
The first position of block waits for that test sample bit transition waits for test sample position to test sample transhipment module from cleaning transhipment module convenient for solid phase unit
The second position is newly loaded the third that bit transition is newly loaded to cleaning transhipment module position from new sample-adding transhipment module convenient for solid phase unit
Position and the 4th position for being transferred to raising module from cleaning transhipment module convenient for solid phase unit, cleaning transhipment module are located at first
When position, cleaning transhipment module waits for that test sample position waits for that test sample bit parallel is aligned with raising module；Cleaning transhipment module is located at second
When setting, cleaning transhipment module waits for that test sample position waits for that test sample bit parallel is aligned with to test sample transhipment module；Cleaning transhipment module is located at the
When three positions, cleaning transhipment module, which is newly loaded position, transports module with the new sample-adding for being located at position III and is newly loaded bit parallel and is aligned；Clearly
Transhipment module is washed when being located at four positions, cleaning, which transports module and is newly loaded position and is newly loaded bit parallel with raising module, to be aligned.
First handgrip transports intermodule straight reciprocating motion in solid phase unit memory module and new sample-adding, for that will consolidate
Phase element is transferred to new sample-adding transhipment module from solid phase unit memory module and is newly loaded on position；Second handgrip is in raising module
Intermodule straight reciprocating motion is transported with cleaning, for solid phase unit to be transported to the transfer of intermodule in raising module and cleaning；
The third handgrip is used for test sample transhipment module, cleaning transhipment module and new sample-adding transhipment intermodule straight reciprocating motion
Cleaning transhipment module is waited for that the solid phase unit on test sample position is transferred to wait on test sample position and will newly be loaded to test sample transhipment module
The solid phase unit that transhipment module is newly loaded on position is transferred to cleaning transhipment module and is newly loaded on position.
By being newly loaded transhipment module, cleaning transhipment module, to the cooperation and first of test sample transhipment block motion and position
The transferance of handgrip, the second handgrip, third handgrip realizes solid phase unit in raising module by being newly loaded position to test sample position
Displacement, realize the single full-automatic tested in sequence of solid phase unit, improve detection efficiency on the basis of improving detection accuracy.
In some preferred modes, cleaning module includes that cleaning transhipment module disposes position, and cleaning transhipment module loads solid
Phase element moves to the placement position and carries out placement and cleaning operation.Cleaning transhipment module can in first motion to cleaning module into
Row placement and cleaning operation facilitate the solid phase unit of each stage of reaction directly and are cleaned simultaneously, easy to operate simple.
In some preferred modes, the system also includes liquid feeding module, the liquid feeding module include sample charger,
Reagent charger and washing lotion charger.Each liquid feeding module can be realized the automatic filling of sample, reaction reagent and washing lotion.
In some preferred modes, the system also includes control system, the control system includes human-computer interaction circle
Face, control system realize the automatic tested in sequence of solid phase unit, continuously obtain testing result by the control to each module；Pass through
Control parameter, including incubation temperature, incubation time, scavenging period and number etc. can be set in human-computer interaction interface.
In some preferred modes, the multiple analytes of setting detect ligand in the solid phase unit, can detect simultaneously
A variety of analytes.
The invention has the advantages that:
1. Full-automatic universal analysis system of the present invention can realize that analyzed sample automatically detects, simple and compact for structure, make
With simple and convenient.
2. the present invention carries out analyte measurement using solid phase unit, solid phase unit can used aloned, and can detect simultaneously
A variety of analytes compare porous plate or microwell plate etc., and operation is easier, are conducive to the consistency for keeping treatment conditions.
3. using Full-automatic universal analysis system of the present invention, it can be achieved that single sample sequence detection, overcomes great amount of samples same
When handle caused by sample process condition it is inconsistent, it is accurate to improve sample measures for the not accurate enough technical problem of measurement result
Property.
4. raising module of the present invention includes that at least one set of solid phase unit for accommodating each step reaction solid phase unit accommodates position, cleaning
The placement position for cleaning transhipment module that there is module placement to have transported one group of solid phase unit, one group of consolidating in each step stage of reaction
Phase element synchronous incubation and synchronous cleaning on cleaning module on raising module, greatly promote detection efficiency.
5. raising module of the present invention setting multiple groups solid phase unit accommodate position, it can be achieved that between each group solid phase unit Non-intermittent into
Row is incubated for and cleaning operation, reduces flow time, improves detection efficiency.
6. each transhipment module of the invention and its movement cooperation are, it can be achieved that one group of solid phase unit in each step stage of reaction exists
Transhipment between raising module and cleaning module, to realize synchronous incubation and cleaning.
Detailed description of the invention
Fig. 1 is Full-automatic universal analysis system top view；`
Fig. 2 is Full-automatic universal analysis system perspective view；
Fig. 3 is long slab shape raising module perspective view；
Fig. 4 .1- Fig. 4 .3 is respectively one embodiment front view of disc raising module, bottom view and perspective view；
Fig. 5 .1- Fig. 5 .2 is respectively another embodiment bottom view of disc raising module and perspective view；
Fig. 6 is Full-automatic universal analysis system simplification top view；
Fig. 7 is that an embodiment cleans top view when shift module is located at first position；
Fig. 8 is that an embodiment cleans top view when shift module is located at the second position；
Fig. 9 is that an embodiment cleans top view when shift module is located at the third place；
Figure 10 is that an embodiment cleans top view when shift module is located at four positions；
Figure 11 is that Full-automatic universal analysis system simplifies perspective view；
Figure 12 is that another embodiment cleans top view when shift module is located at first position；
Figure 13 is that another embodiment cleans top view when shift module is located at the second position；
Figure 14 is that another embodiment cleans top view when shift module is located at the third place.
Specific embodiment
For ease of understanding, part-structure of the present invention or technical term are described further first:
Analyte: can with the substance in conjunction with specificity ligand specificity, including but not limited to all kinds of antigens, antibody,
Polypeptide, albumen, nucleic acid etc..
Solid phase unit:
Solid phase unit is the container that one kind can carry liquid, is fixed on inner surface special with analyte (sample)
The ligand dot matrix of property association reaction.
Three-step approach, two-step method:
Enzyme mark+substrate solution is one of the measuring method enumerated in above table, it is not limited to this.
It is understandable to enable objects, features and advantages of the present invention to become apparent, with reference to the accompanying drawing to tool of the invention
Body embodiment is described in detail.
As shown in Figs. 1-2, a kind of Full-automatic universal analysis system 100, including solid phase unit 110, solid phase unit store mould
Block 120, sample storage module 130, reagent memory module 140, raising module 150, cleaning module 160, measurement module 170, are incubated
Educating module 150 includes that at least one set of solid phase unit for accommodating differential responses stage solid phase unit 110 accommodates position 1510, every group of solid phase
It includes newly being loaded position 1511 and to test sample position 1512 that unit, which accommodates position 1510,.
Raising module 150 incubates the multi-orifice devices that disk is constituted by metal thermal conductive material, electroluminescent heating film, heat-insulating material.Just
To after placement, hole is arranged in the top of equipment, and each hole accommodates position as a solid phase unit, for solid phase unit receiving,
Incubation reaction and temperature are adjusted.It is accommodated in position when solid phase unit to be inserted into solid phase unit, the fluid temperature inside solid phase unit
Temperature in position will be accommodated by solid phase unit to adjust, and be treated as being incubated for through constant temperature after a period of time.By being incubated for, solid single
Ligand specificity reaction in member will reach balance.So-called balance, exactly the reaction between assigning body will not be with incubation time
Continue to extend and the variation in apparent amount occurs.
Usually within the scope of certain temperature, the reaction presentation reaction temperature that ligand specificity combines is higher, reaches balance
Shorter feature of required time, as the relationship in chemical reaction between reaction speed and temperature.Using this
Principle, temperature can be turned up in the hole of raising module, to increase reaction speed, shorten the effect in reaction time.
Therefore, in some embodiments, multistep reaction is measured, 150 same groups of solid phase units of raising module accommodate position
1510 are arranged to that temperature control can be distinguished, and adjust temperature in each receiving position according to equilibration time, so that consolidating in the differential responses stage
The incubation of phase element 110 duration is identical, can reach balance simultaneously, so as to carry out the cleaning operation of next step simultaneously.
In some embodiments, as shown in Figure 1-3, raising module 150 includes that long slab shape incubates disk 151, long slab shape is incubated
Disk 151 is set in relatively closed chamber 152, and long slab shape incubates disk 151 can do intermittent control shaking, long slab shape in the horizontal direction
151 bottom of disk setting temperature and vibration control apparatus (not shown) are incubated, long slab shape incubates at least one set of solid phase unit on disk 151
It is arranged in parallel along long slab shape incubation disk length direction to accommodate position 1510.
In some embodiments, as shown in Fig. 4 .1- Fig. 4 .3, raising module 150 ' includes disc incubation disk 151 ', until
Few one group of solid phase unit accommodates position 1510 ' and arranges thereon by circumferential direction, every group of solid phase unit accommodate the midpoint of position line with
The line in the center of circle is vertical with every group of solid phase unit receiving position line, at least one circle can be set as needed, such as Fig. 4 .2 and Fig. 4 .3
Two circle of display setting, disc incubate 151 ' lower section of disk and rotating device 152 ' are arranged, and lid 153 ' is arranged in top, and lid 153 ' has
There is the opening 154 ' for exposing one group of solid phase unit, rotating device 152 ' drives disc to incubate disk 151 ' and rotates, and lid
153 ' is motionless, so that the opening 154 ' that different group solid phase units successively expose to lid 153 ' is located, convenient for transhipment solid single
Member.
In further embodiments, as shown in Fig. 5 .1- Fig. 5 .2, raising module 150 ' includes that disc incubates disk 151 ',
At least one set of solid phase unit accommodates position 1510 ' and arranges thereon by circumferential direction, and every group of solid phase unit accommodates 1510 ' line of position
Extended line is by the center of circle.
When in some embodiments, for needing to carry out analyte analysis measurement using three-step approach, raising module 150 is set
It is set to every group of solid phase unit and accommodates position 1510 containing N1 aligned solid phase units receiving positions, wherein N1=3n, n are whole
Number, it includes newly being loaded position to test sample position 1512 positioned at the n new sample-adding positions 1511 at both ends and n that every group of solid phase unit, which accommodates position,
The 1511 solid phase unit for solid phase unit newly-increased every time namely in first step reaction accommodates；And it is used for test sample position 1512
Final step is incubated for and will carry out the solid phase unit of cleaning detection namely accommodate in the solid phase unit of third step reaction；In and
Between n solid phase unit accommodate position be used in second step reaction solid phase unit receiving.150 every groups of solid singles of raising module
Member, which accommodates position 1510, may be configured as 3 (as shown in Fig. 1-3, Fig. 4 .2, Fig. 5 .1), 6,9, and so on, work as raising module
When 150 every groups of solid phase units receiving positions are set as 3, every group of solid phase unit accommodates 1 that position includes point column straight line both ends and newly adds
Sample position 1511 and 1 is predictable to test sample position 1512, when every group of solid phase unit of raising module, which accommodates position, is arranged to 6, often
It includes 2 new sample-adding positions 1511 and 2 at point column both ends to test sample position 1512 that group solid phase unit, which accommodates position,.In view of loading time
Influence to testing result, every group of solid phase element number should not be excessive, may be selected 3,6 or 9.Every group of solid phase unit in this way
Accommodating position includes the new sample-adding position 1511 for the new reinforcing phase element that one end is used to accommodate first step reaction, centre for accommodating second
The solid phase to be measured that the receiving position and the other end for walking the solid phase unit of reaction are used to accommodate third step reaction and will be detected
Unit to test sample position 1512.
In this way, 150 same groups of solid phase units of raising module accommodate in position comprising the solid phase in three differential responses stages
Unit 110.After incubation reaction, same group of solid phase unit 110 is transferred to cleaning module 160 and carries out cleaning step, has cleaned
Cheng Hou, original are transported to measurement module 170 to the solid phase unit to be measured on test sample position and are measured, remaining solid phase unit 110 is again
It is transported on raising module 150, and accommodates in raising module and shifted on position, is i.e. the solid phase unit that is reacted in the first step of original place
Intermediate solid phase unit is transferred to accommodate in position, original place is transferred in the solid phase unit that second step reacts in test sample position 1512,
The solid phase unit in first step reaction newly-increased simultaneously is placed on new sample-adding position 1511, is incubated for again.
When in some embodiments, for needing to carry out analyte analysis measurement using two-step method, raising module setting
Position is accommodated at every group of solid phase unit and accommodates position containing N1 aligned solid phase units, and wherein N1=2n, n are integer, often
It includes new sample-adding positions n positioned at both ends and n to test sample position that group solid phase unit, which accommodates position, and the new position that is loaded is for newly-increased every time
Namely the solid phase unit in first step reaction accommodates, and be incubated for test sample position for final step and cleaning detection will be carried out
Namely in second step reaction solid phase unit accommodate.Every group of solid phase unit of raising module accommodate position may be configured as 2,4,
6, and so on, when every group of solid phase unit of raising module, which accommodates position, is set as 2, it includes point that every group of solid phase unit, which accommodates position,
1 of column straight line both ends new sample-adding position and 1 are predictable to test sample position, set when every group of solid phase unit of raising module accommodates position
When being set to 4, every group of solid phase unit accommodates 2 that position includes point column both ends and is newly loaded positions and 2 to test sample position.In view of sample-adding
Influence of the time to testing result, every group of solid phase element number should not be excessive, may be selected 2,4 or 6.Every group of solid phase in this way
Unit accommodates the new sample-adding position that position includes the new reinforcing phase element that one end is used to accommodate first step reaction and the other end for holding
Second step of receiving react and the solid phase unit to be measured that will be detected to test sample position.
In this way, same group of solid phase unit of raising module accommodates in position comprising the solid single in two differential responses stages
Member.After incubation reaction, same group of solid phase unit is transferred to cleaning module and carries out cleaning step, former to be measured after the completion of cleaning
Solid phase unit to be measured on sample position is transported to measurement module and is measured, and the solid phase unit on former new sample-adding position is transported to again incubates
Educate in module, and raising module accommodate position on shifted namely original place in the solid phase unit that the first step is reacted be transferred to
On test sample position, while the newly-increased solid phase unit in first step reaction is placed in raising module and is newly loaded on position, is incubated for again.
In some embodiments, for two-step method or three-step approach, it can be used general raising module, N1=3n, namely
Every group of raising module solid phase unit, which accommodates position, may be configured as 3,6,9 and so on, when carrying out two-step method, can choose
Adjacent 2n solid phase unit accommodates position respectively as n new sample-adding positions and n to test sample position in 3n, without by raising module
It is changed to every group of solid phase unit and accommodates the raising module that position is 2n, namely be set as when every group of raising module solid phase unit accommodates position
At 3, the first two or latter two solid phase unit is selected to accommodate position as new sample-adding position and to test sample position, in this way for three-step approach
Raising module can be used for two-step method, without replacing raising module.
In some embodiments, 150 solid phase unit of raising module accommodates hyte number N2=T/t, and wherein T is that solid phase unit adds
Enter raising module solid phase unit and accommodates position to addition raising module solid phase unit receiving bit interval duration, namely completion one again
The time used is recycled, t is that one group of solid phase unit immigration raising module solid phase unit receiving position to next group of solid phase unit immigration is incubated
It educates module solid phase unit and accommodates bit interval duration, such as T is 10min, one group of solid phase unit, which moves into raising module solid phase unit, to be held
Position to next group of solid phase unit of receiving moves into raising module solid phase unit and accommodates a length of 0.5min, T/t=10/0.5=when bit interval
20, then N2 takes 20 groups.As shown in Fig. 1, Fig. 5 .1, raising module solid single number of tuples is 20 groups.
In some embodiments, as shown in fig. 6, the system also includes transhipment module, the transhipment module includes new adds
Sample transports module 181, cleaning transhipment module 182, transports module 183, the first handgrip 184, the second handgrip 185, third to test sample
Handgrip 186, the new sample-adding transhipment module 181 includes that N3 solid phase unit is newly loaded position 1811, wherein N3=n；It is described to be measured
It includes N4 solid phase unit sample position 1831 to be measured that sample, which transports module 183, wherein N4=n, as shown in fig. 6, new sample-adding transhipment module
181 are newly loaded position 1811 comprising 1 solid phase unit, include 1 solid phase unit sample position 1831 to be measured to test sample transhipment module 183.
In some embodiments, the cleaning transhipment module includes that one group of N5 aligned solid phase unit accommodates
Position, wherein N5=N1+n, solid phase unit receiving position include that the n solid phase unit positioned at both ends is newly loaded position and n solid phase unit
To test sample.By taking n=1 as an example, metal is incubated for 151 every groups of disk and accommodates comprising 3 solid phase units in raising module 150 as shown in Figure 6
Position, Far Left are new sample-adding position 1511, and rightmost is to test sample position 1512；Cleaning transhipment module 182 includes 4 receiving positions, most
The left side is new sample-adding position 1821, and rightmost is to test sample position 1822；New sample-adding transhipment module 181 includes 1 new sample-adding position 1811,
To test sample transhipment module 183 containing 1 to test sample position 1831.Cleaning transhipment module 182, new sample-adding transport module 181, to test sample
Module 183 is transported along straight reciprocating motion, the first handgrip 184 be located in solid phase unit memory module 120 solid phase unit just on
Side has 1 solid phase unit picks position, can be along straight reciprocating motion.Second handgrip 185 is located at long slab shape in raising module 150
It incubates right above disk 151, there are 3 solid phase unit picks positions, it can be along incubation 151 length direction straight reciprocating motion of disk.Third
Handgrip 186 has 1 solid phase unit picks position, along straight reciprocating motion.
Cleaning transhipment module includes 4 positions in moving along a straight line, when being located at first position, as shown in fig. 7, cleaning turns
Module 182 is transported to test sample position 1822 and raising module 150 to 1512 parallel alignment of test sample position, at this moment the second handgrip 185 crawl is incubated
Educate 3 in module 150 and be in the solid phase units in differential responses stage, and move along a straight line to cleaning transhipment module 182 just on
Solid phase unit on raising module 150 is aligned one by one and is transported on the cleaning transhipment receiving of module 182 position by side.Then cleaning turns
It transports module 182 and transports solid phase unit to cleaning module 160, complete filling washing lotion and cleaning, the first handgrip 184 grabs during this period
Solid phase unit 110 in solid phase storage module 120 and along linear to the new sample-adding for being located at position I transport module 181 newly plus
On sample position 1811, then new sample-adding transhipment module 181 moves to the position II of sample-adding.Cleaning transhipment module 182 is subsequently transferred to
The second position measures outside module, cleaning as shown in figure 8, transporting module 183 to test sample simultaneously and moving to out of measurement module 170
Transport module 182 to test sample position 1822 (being located at the lower section of third handgrip 186, do not show in Fig. 8) with to test sample transport module 183 to
1831 parallel alignment of test sample position, the crawl cleaning transhipment module 182 of third handgrip 186 is to the solid phase unit on test sample position 1822 and edge
Linear transports module 183 to transport solid phase unit along straight line to test sample transhipment module 183 on test sample position 1831 to test sample
It moves in measurement module 170 and is measured.When cleaning transhipment module 182 moves to the third place, as shown in figure 9, completing to add
The solid phase unit of sample is transferred to position III by new sample-adding transhipment module 181, the module 182 of cleaning transhipment at this time newly sample-adding position 1821 with
Newly (the newly sample-adding position 1821 of module 182 is transported in cleaning to sample-adding 1811 parallel alignment of position to new sample-adding transhipment module 181 positioned at position III
Newly be located at below third handgrip 186 sample-adding position 1811 with new sample-adding transhipment module 181, do not shown in Fig. 9), third handgrip 186 from
New sample-adding transhipment module 181, which is newly loaded on position 1811 to grab solid phase unit and be transferred to cleaning transhipment module 182, is newly loaded position
On 1821.Then cleaning transhipment module 182 moves to the 4th position, and as shown in Figure 10, the module 182 of cleaning transhipment at this time is newly loaded
Position 1821 is newly loaded 1511 parallel alignment of position with raising module 150, and (cleaning transhipment module 182 newly grab positioned at second by sample-adding position 1821
Below hand 185, do not shown in Figure 10), cleaning is transported the solid phase unit picks in module 182 and an a pair by the second handgrip 185
It is transferred on raising module 150 together, the solid phase unit that cleaning transhipment module 182 is newly loaded on position 1821 after transfer, which is located at, is incubated for mould
Block 150 is newly on sample-adding position 1511.Then, the second handgrip grabs next group of solid phase unit and carries out aforesaid operations, and circuits sequentially.
In some embodiments, the cleaning transhipment module 182 includes that one group of N5 aligned solid phase unit holds
Receive position, wherein N5=N1, namely cleaning transhipment 182 solid phase unit of module accommodates the 150 1 groups of solid phase units in position and raising module and holds
Bit quantity of receiving is identical, and it includes positioned at the n solid phase unit sample position 1512 to be measured of one end that cleaning transhipment module solid phase unit, which accommodates position,.
By taking n=1 as an example, as shown in figs. 12-14,150 every groups of raising module accommodate position comprising 3 solid phase units, and Far Left is new sample-adding
Position 1511, rightmost are to test sample position 1512；Cleaning transhipment module 182 includes 3 receiving positions, and rightmost is to test sample position
1822；New sample-adding transhipment module 181 includes 1 new sample-adding position 1811, includes 1 to test sample position to test sample transhipment module 183
1831.Cleaning transhipment module 182, new sample-adding transhipment module 181, to test sample transhipment module 183 along straight reciprocating motion, first
Handgrip 184 is located at right above the solid phase unit in solid phase unit memory module 120, has 1 solid phase unit picks position, can be along straight
Line moves back and forth.Second handgrip 185 is located at long slab shape in raising module 150 and incubates right above disk 151, has 3 solid phase units
Position is grabbed, it can be along incubation 151 length direction straight reciprocating motion of disk.Third handgrip 186 has 1 solid phase unit picks position, edge
Straight reciprocating motion.
Cleaning transhipment module 182 includes 3 positions in moving along a straight line, when being located at first position, as shown in figure 12, clearly
Transhipment module 182 is washed to test sample position 1822 and raising module 150 to 1512 parallel alignment of test sample position, at this moment the second handgrip 185 is grabbed
It takes 3 on raising module 150 to be in the solid phase unit in differential responses stage, and moves along a straight line and transport module 182 to cleaning
Solid phase unit is aligned one by one and is transferred in cleaning transhipment module 182 by surface, and raising module 150 is to test sample position after transfer
Solid phase unit on 1512 is located at cleaning transhipment module 182 on test sample position 1822.Then cleaning transhipment module 182 transports solid phase
Unit completes filling washing lotion and cleaning, during this period in the first handgrip 184 crawl solid phase storage module 120 to cleaning module 160
Solid phase unit 110 and along linear to be located at position I new sample-adding transport module 181 newly sample-adding position along 1811, then newly
Sample-adding transhipment module 181 moves to the position II of sample-adding, this stylish sample-adding transhipment module 181 is located at cleaning transhipment module 182
On same straight line, and newly sample-adding position 1811 is newly loaded that position 1511 is parallel to be staggered with raising module 150 to new sample-adding transhipment module 181.
Cleaning transhipment module 182 then moves to the second position (as shown in figure 13), while transporting module 183 from measurement module to test sample
It is moved in 170 outside measurement module 170, cleaning transhipment module 182 (is located at 186 lower section of third handgrip, Figure 13 to test sample position 1822
In do not show) transport module 183 to 1831 parallel alignment of test sample position with to test sample, the crawl cleaning transhipment module of third handgrip 186
182 transport module 183 on test sample position 1831 to test sample to the solid phase unit on test sample position 1822 and along linear, to be measured
Sample transhipment module 183 transport solid phase unit move along a straight line to measurement module 170 in be measured.Cleaning transhipment module 182 is transported
When moving to the third place, as shown in figure 14, the new solid phase unit for completing sample-adding is transferred to position by new sample-adding transhipment module 181
III, this stylish sample-adding transhipment module 181 and cleaning transport module 182 and are located at same straight line, and new sample-adding transhipment module 181 newly adds
Newly (newly sample-adding position 1811 is located at the to new sample-adding transhipment module 181 to sample-adding 1511 parallel alignment of position for sample position 1811 and raising module 150
Below two handgrip 185, do not shown in Figure 14), new sample-adding transhipment module 181 is newly loaded position 1811 and transports module 182 close to cleaning,
New sample-adding transhipment module 181 is newly loaded the solid phase unit picks on position 1811 and cleaning transhipment module 182 simultaneously by the second handgrip 185
Alignment is transferred on raising module 150 one by one, and newly sample-adding transhipment module 181 is newly loaded the solid phase unit position on position 1811 after transfer
In on raising module 150 newly sample-adding position 1511.Then, next group of solid phase unit progress aforesaid operations of the second handgrip crawl, and according to
Secondary circulation.
In some embodiments, as shown in figure 3, in order to preferably keep the stabilization of the incubation environment in raising module 150,
In raising module side, setting passes in and out the intracavitary channel of raising module 150 for cleaning transhipment module 182, and solid phase unit 110 is being incubated
The transfer generation educated between module 150 and cleaning transhipment module 182 is intracavitary in raising module 150.Equally, solid phase unit memory module
The setting of 120 sides passes in and out the channel of solid phase unit memory module 120 for new sample-adding transhipment module 181, and solid phase unit 110 is in solid phase
It is new to new sample-adding transhipment module 181 by 120 solid phase unit of solid phase unit memory module receiving bit transition in unit memory module 120
It is loaded on position 1811.
In some embodiments, as shown in figure 11, the system also includes liquid feeding modules, and the liquid feeding module includes sample
Charger 191, for filling sample；Reagent charger 192, for filling reaction reagent, for three-step approach, reagent charger packet
It includes the first reagent charger 1921 of filling second step reaction reagent and fills the second reagent charger of third step reaction reagent
1922；And washing lotion charger 193, for filling washing lotion.Each liquid feeding module can be realized the automatic of sample, reaction reagent and washing lotion
Filling.
In some embodiments, the system also includes control system, the control system includes human-computer interaction interface, control
System processed realizes the automatic tested in sequence of solid phase unit, continuously obtains testing result by the control to each module；Pass through man-machine friendship
Control parameter, including incubation temperature, incubation time, scavenging period and number etc. can be set in mutual interface.
Although present disclosure is as above, present invention is not limited to this.Anyone skilled in the art are not departing from this
It in the spirit and scope of invention, can make various changes or modifications, therefore protection scope of the present invention should be with claim institute
Subject to the range of restriction.
Claims (22)
1. a kind of Full-automatic universal analysis system, which is characterized in that deposited including solid phase unit, solid phase unit memory module, sample
Module, reagent memory module, raising module, cleaning module, measurement module are stored up, raising module includes that at least one set of each step of receiving is anti-
The solid phase unit of stage solid phase unit is answered to accommodate position, it includes newly being loaded position and to test sample position that every group of solid phase unit, which accommodates position,.
2. the system as claimed in claim 1, which is characterized in that every group of solid phase unit of raising module accommodates position and contain N1 Cheng Zhi
The solid phase unit receiving position that line arranges, wherein N1=2n or 3n, every group of solid phase unit accommodate n that position includes point column both ends and newly add
Sample position and n are a to test sample position.
3. system as claimed in claim 2, preferably n=1 or 2 or 3.
4. the system as claimed in claim 1, the raising module solid phase unit accommodates hyte number N2=T/t, and wherein T is solid phase
It is upper that unit, which is added raising module solid phase unit and accommodates position to raising module solid phase unit receiving bit interval duration, t are added again,
One group of solid phase unit moves into raising module solid phase unit and accommodates position to next group of solid phase unit immigration raising module solid phase unit appearance
Receive bit interval duration.
5. the system as claimed in claim 1, which is characterized in that the raising module includes that long slab shape incubates disk, at least one set of
It is arranged in parallel along its length thereon that solid phase unit accommodates position.
6. the system as claimed in claim 1, which is characterized in that the raising module includes that disc incubates disk, at least one set of
Solid phase unit accommodates position and arranges along circumferential direction thereon.
7. system as claimed in claim 6, which is characterized in that every group of solid phase unit accommodates the midpoint of position line and the company in the center of circle
Line accommodates vertical or every group of solid phase unit of position line with every group of solid phase unit and accommodates the extended line of position line by the center of circle.
8. system as claimed in claim 6, which is characterized in that the incubation pan bottom is provided with rotating device, incubates disk also
Equipped with lid, lid has the opening for exposing one group of solid phase unit.
9. system as described in one of claim 1-8, which is characterized in that the system also includes transhipment module, the transhipments
Module includes new sample-adding transhipment module, cleans transhipment module, grabs to test sample transhipment module, the first handgrip, the second handgrip, third
Hand.
10. system as claimed in claim 9, which is characterized in that the new sample-adding transhipment module includes that N3 solid phase unit is new
It is loaded position, wherein N3=n；Described to test sample transhipment module includes N4 solid phase unit sample position to be measured, wherein N4=n.
11. system as claimed in claim 10, which is characterized in that the cleaning transhipment module includes the one group of N5 row of being in line
The solid phase unit of column accommodates position, wherein N5=N1, and it includes the n solid phase unit sample to be measured positioned at one end that solid phase unit, which accommodates position,
Position.
12. system as claimed in claim 11, which is characterized in that new sample-adding transhipment module is along straight reciprocating motion, with cleaning
Transhipment module is located along the same line, and has and is transferred to new sample-adding transhipment module from solid phase unit memory module convenient for solid phase unit
Position I, convenient for the position II of sample-adding and convenient for solid phase unit be newly loaded bit transition to raising module from new sample-adding transhipment module
The position III of new sample-adding position, when being located at position III, new sample-adding transhipment module is newly loaded position and raising module is newly loaded bit parallel pair
Together.
13. system as claimed in claim 12, which is characterized in that cleaning transhipment module has first along straight reciprocating motion
Position, the second position and the third place, when cleaning transhipment module is located at first position, cleaning transhipment module waits for test sample position and is incubated for
Module waits for that test sample bit parallel is aligned；When cleaning transhipment module is located at the second position, cleaning transhipment module waits for test sample position and to test sample
Transhipment module waits for that test sample bit parallel is aligned；When cleaning transhipment module is located at the third place, cleaning transhipment module is immediately adjacent to position
III new sample-adding transports module.
14. system as claimed in claim 13, which is characterized in that first handgrip is in solid phase unit memory module and Xin Jia
Sample transports intermodule straight reciprocating motion, and second handgrip is in raising module, cleaning transhipment module and new sample-adding transhipment module
Between straight reciprocating motion, the third handgrip to test sample transhipment module and cleaning transhipment intermodule straight reciprocating motion.
15. system as claimed in claim 10, which is characterized in that the cleaning transhipment module includes the one group of N5 row of being in line
The solid phase unit of column accommodates position, wherein N5=N1+n, and it includes that the n solid phase unit positioned at both ends is newly loaded that solid phase unit, which accommodates position,
Position and n solid phase unit sample to be measured.
16. system as claimed in claim 15, which is characterized in that new sample-adding transhipment module has just along straight reciprocating motion
It is transferred to from solid phase unit memory module the position I of new sample-adding transhipment module, in solid phase unit convenient for the position II and just of sample-adding
Bit transition to cleaning is newly loaded from new sample-adding transhipment module in solid phase unit and transports the position III that module is newly loaded position, is located at position
When III, new sample-adding transhipment module, which is newly loaded position, with cleaning transports module and is newly loaded bit parallel and be aligned.
17. system as claimed in claim 16, which is characterized in that cleaning transhipment module has first along straight reciprocating motion
Position, the second position, the third place and the 4th position, when cleaning transhipment module is located at first position, cleaning transhipment module is to be measured
Wait for that test sample bit parallel is aligned with raising module in sample position；When cleaning transhipment module is located at the second position, cleaning transhipment module waits for test sample
Wait for that test sample bit parallel is aligned with to test sample transhipment module in position；When cleaning transhipment module is located at the third place, cleaning transhipment module is new
Sample-adding position is newly loaded bit parallel with the new sample-adding transhipment module for being located at position III and is aligned；Cleaning transhipment module is located at the 4th position
When, cleaning transhipment module, which is newly loaded position and is newly loaded bit parallel with raising module, to be aligned.
18. system as claimed in claim 17, which is characterized in that first handgrip is in solid phase unit memory module and Xin Jia
Sample transports intermodule straight reciprocating motion, and second handgrip transports intermodule straight reciprocating motion in raising module and cleaning,
The third handgrip is to test sample transhipment module, cleaning transhipment module and new sample-adding transhipment intermodule straight reciprocating motion.
19. system as claimed in claim 9, which is characterized in that the cleaning module includes that cleaning transhipment module disposes position, clearly
It washes transhipment block motion to the placement position and carries out placement and cleaning operation.
20. the system as claimed in claim 1, which is characterized in that the system also includes liquid feeding module, the liquid feeding module packet
Include sample charger, reagent charger and washing lotion charger.
21. the system as claimed in claim 1, which is characterized in that the system also includes control system, the control system packet
Include human-computer interaction interface.
22. the system as claimed in claim 1, which is characterized in that the multiple analyte detections of setting are matched in the solid phase unit
Body.
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| CN201910606062.XA CN110261591A (en) | 2019-07-05 | 2019-07-05 | A kind of Full-automatic universal analysis system |
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| US20090047178A1 (en) * | 2005-11-10 | 2009-02-19 | Maxmat Sa | Automatic Biotesting Device |
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