CN110251844B

CN110251844B - Photothermal treatment method and system based on terahertz imaging and industrial personal computer

Info

Publication number: CN110251844B
Application number: CN201910404126.8A
Authority: CN
Inventors: 杨少壮; 李辰
Original assignee: Shenzhen Institute of Terahertz Technology and Innovation
Current assignee: Shenzhen Institute of Terahertz Technology and Innovation
Priority date: 2019-05-15
Filing date: 2019-05-15
Publication date: 2021-06-15
Anticipated expiration: 2039-05-15
Also published as: CN110251844A

Abstract

The invention is suitable for the technical field of photothermal therapy, and provides a photothermal therapy method, a system and an industrial personal computer based on terahertz imaging.A terahertz spectrum and imaging information of an object to be treated are acquired and analyzed by emitting detection light, radiating terahertz waves to the object to be treated, processing the detection light and the terahertz waves reflected by the object to be treated into digital signals and generating terahertz pulse signals, so that a region to be treated of the object to be treated is identified; injecting a predetermined dose of photothermal agent into the area to be treated; the method comprises the steps of radiating pulse laser to a region to be treated for photothermal treatment, synchronously acquiring terahertz spectrum and imaging information of an object to be treated, monitoring the effect of photothermal treatment, and adjusting parameters of the pulse laser, the size of preset dosage and the duration of photothermal treatment according to effect feedback, so that targeted identification, image monitoring and treatment of the region to be treated can be realized simultaneously, the synergy is good, and no external interference factor exists.

Description

Photothermal treatment method and system based on terahertz imaging and industrial personal computer

Technical Field

The invention belongs to the technical field of photothermal therapy, and particularly relates to a photothermal therapy method and system based on terahertz imaging and an industrial personal computer.

Background

The photothermal therapy technology takes near-infrared light with strong tissue penetrating power as an energy light source, takes a nano material with high photothermal conversion efficiency, good biocompatibility and low toxicity as a photothermal reagent, modifies a tumor marker identification group on the photothermal reagent, performs targeted tumor identification and enrichment after the photothermal reagent is injected into a patient, generates heat under the irradiation of the energy light source, and achieves the purposes of targeted tumor tissue destruction and cancer cell killing. As a new treatment means, the photothermal treatment technology has the advantages of high targeting property, high treatment speed, side effects, few complications and the like, and shows wide application prospect in tumor treatment.

However, the existing photothermal therapy technology cannot simultaneously perform targeted identification, image monitoring and therapy on tumors, has poor synergistic effect, complex structure and high cost, is easy to introduce external interference factors, and is difficult to meet the requirements of high-efficiency, accurate and multifunctional practical application.

Disclosure of Invention

In view of this, embodiments of the present invention provide a photothermal therapy method, a system and an industrial personal computer based on terahertz imaging, so as to solve the problems that the existing photothermal therapy technology cannot simultaneously perform targeted identification, image monitoring and therapy on tumors, is poor in synergistic effect, complex in structure, high in cost, easy to introduce external interference factors, and difficult to meet the requirements of efficient, accurate and multifunctional practical applications.

The embodiment of the invention provides a photothermal treatment method based on terahertz imaging, which is applied to a photothermal treatment system based on terahertz imaging, wherein the photothermal treatment system comprises an industrial personal computer, a laser emitting mechanism and an injection device, and the laser emitting mechanism and the injection device are electrically connected with the industrial personal computer, and the photothermal treatment method comprises the following operations executed by the industrial personal computer:

controlling a laser emission mechanism to emit detection light and radiate terahertz waves to an object to be treated, generating micro-current signals according to the detection light and the terahertz waves reflected by the object to be treated, and processing the micro-current signals into digital signals;

generating a terahertz pulse signal according to the digital signal, and acquiring a terahertz spectrum and imaging information of the object to be treated according to the terahertz pulse signal;

analyzing the terahertz spectrum and the imaging information of the object to be treated, and identifying the area to be treated of the object to be treated;

controlling the injection device to inject a preset dose of photothermal agent into the area to be treated;

controlling the laser emission mechanism to radiate pulse laser to the area to be treated, and carrying out photothermal treatment on the area to be treated;

in the process of carrying out photothermal therapy on the region to be treated, synchronously acquiring the terahertz spectrum and the imaging information of the object to be treated, and monitoring the effect of the photothermal therapy;

and feedback-adjusting the parameters of the pulse laser, the preset dosage and the duration of the photothermal therapy according to the effect of the photothermal therapy.

The second aspect of the embodiment of the invention provides a photothermal therapy system based on terahertz imaging, which comprises an industrial personal computer, a laser emitting mechanism and an injection device, wherein the laser emitting mechanism and the injection device are electrically connected with the industrial personal computer;

the industrial computer comprises:

the first control module is used for controlling the laser emitting mechanism to emit detection light and radiate terahertz waves to an object to be treated, generating micro-current signals according to the detection light and the terahertz waves reflected by the object to be treated and processing the micro-current signals into digital signals;

the imaging module is used for generating a terahertz pulse signal according to the digital signal and acquiring a terahertz spectrum and imaging information of the object to be treated according to the terahertz pulse signal;

the identification module is used for analyzing the terahertz spectrum and the imaging information of the object to be treated and identifying the area to be treated of the object to be treated;

the second control module is used for controlling the injection device to inject a preset dose of photothermal agent into the area to be treated;

the third control module is used for controlling the laser emitting mechanism to radiate pulse laser to the area to be treated and carrying out photothermal treatment on the area to be treated;

the monitoring module is used for synchronously acquiring the terahertz spectrum and the imaging information of the object to be treated in the process of performing photothermal treatment on the area to be treated, and monitoring the effect of the photothermal treatment;

and the adjusting module is used for adjusting the parameters of the pulse laser, the size of the preset dosage and the duration of the photothermal therapy according to the effect feedback of the photothermal therapy.

A third aspect of embodiments of the present invention provides an industrial personal computer, which includes a memory, a processor, a display screen, and a computer program stored in the memory and executable on the processor, and when the processor executes the computer program, the steps of the photothermal treatment method described above are implemented.

A fourth aspect of embodiments of the present invention provides a computer-readable storage medium having stored thereon a computer program which, when executed by a processor, performs the steps of the above-described method of photothermal therapy.

The embodiment of the invention provides a photothermal treatment method applied to a photothermal treatment system based on terahertz imaging, which comprises an industrial personal computer, a laser emission mechanism and an injection device, wherein the laser emission mechanism is electrically connected with the industrial personal computer; the injection device is controlled by the industrial personal computer to inject a preset dose of photothermal reagent into the area to be treated, and the laser emission mechanism is controlled to radiate pulse laser to the area to be treated, so that photothermal treatment can be carried out on the area to be treated; the terahertz spectrum and the imaging information of the object to be treated are synchronously acquired by the industrial personal computer in the process of performing photothermal treatment on the area to be treated, the effect of the photothermal treatment is monitored, and intraoperative monitoring of the object to be treated can be realized; the post-operation tracking of the object to be treated can be realized through the industrial personal computer according to the effect feedback adjustment pulse laser of the photothermal treatment, the size of the preset dosage and the duration of the photothermal treatment, the target identification and the image monitoring and treatment of the region to be treated can be realized simultaneously, the cooperative action is good, the structure is simple, the cost is low, no external interference factor exists, and the high-efficiency, accurate and multifunctional practical application requirements can be met.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed for the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

FIG. 1 is a schematic view of a photothermal treatment system according to an embodiment of the present invention;

FIG. 2 is a schematic flow chart of a photothermal treatment method provided in accordance with an embodiment of the present invention;

FIG. 3 is a schematic view of a photothermal treatment system provided in accordance with a second embodiment of the present invention;

FIG. 4 is a schematic flow chart of a photothermal treatment method provided in accordance with a second embodiment of the present invention;

FIG. 5 is a schematic structural diagram of an injection device according to a second embodiment of the present invention;

FIG. 6 is a schematic flow chart of a photothermal treatment method provided in accordance with a second embodiment of the present invention;

FIG. 7 is a schematic view of a photothermal treatment system provided in accordance with a third embodiment of the present invention;

fig. 8 is a schematic structural diagram of an industrial personal computer provided in the fourth embodiment of the present invention.

Detailed Description

In order to make the technical solutions of the present invention better understood by those skilled in the art, the technical solutions in the embodiments of the present invention will be clearly described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The terms "comprises" and "comprising," and any variations thereof, in the description and claims of this invention and the above-described drawings are intended to cover non-exclusive inclusions. For example, a process, method, or system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus. Furthermore, the terms "first," "second," and "third," etc. are used to distinguish between different objects and are not used to describe a particular order.

Example one

As shown in fig. 1, the present embodiment provides a photothermal therapy system 100 based on terahertz imaging, including an industrial personal computer 1, and a laser emission mechanism 2 and an injection device 3 electrically connected to the industrial personal computer 1.

In a specific application, an Industrial Personal Computer (IPC), i.e., an Industrial control Computer, may be a conventional Industrial Computer, or may be a computing device such as a smart phone, a tablet Computer, a Personal digital assistant, a notebook Computer, a desktop Computer, a Personal Computer connected with a display, or a server.

In the present embodiment, the laser emitting mechanism has a function of radiating terahertz waves and detecting terahertz waves, and the injection device has a function of automatically injecting a photothermal agent.

As shown in fig. 2, based on the photothermal treatment system 100 shown in fig. 1, the photothermal treatment method provided by the present embodiment includes the following operations performed by the industrial personal computer 1:

step S201, controlling a laser emitting mechanism to emit detection light and radiate terahertz waves to an object to be treated, generating micro-current signals according to the detection light and the terahertz waves reflected by the object to be treated, and processing the micro-current signals into digital signals.

In a specific application, the subject to be treated may be a tumor patient (e.g., an epithelial cell canceration patient) or a subject (e.g., a nude mouse) transplanted in advance and having a tumor (e.g., melanoma) grown thereon.

In specific application, an object to be treated is placed on a treatment table, the treatment table can be a three-dimensional displacement platform electrically connected with an industrial personal computer, and the position of the treatment table in a three-dimensional space can be adjusted according to actual needs, so that the object to be treated on the treatment table can be moved to an optimal treatment area, for example, a terahertz wave radiation area of a laser emission mechanism. The treatment table can be of a completely hollow structure or a middle hollow structure, and the interference on the photothermal treatment caused by the manufacturing material factor of the treatment table can be reduced.

As shown in fig. 1, a treatment table 200 electrically connected to the industrial personal computer 1 is exemplarily shown.

In the embodiment, the laser emission mechanism is used for emitting detection light under the control of the industrial personal computer, radiating terahertz waves to an object to be treated, generating micro-current signals according to the detection light and the terahertz waves reflected by the object to be treated, and processing the micro-current signals into digital signals.

Step S202, generating a terahertz pulse signal according to the digital signal, and acquiring a terahertz spectrum and imaging information of the object to be treated according to the terahertz pulse signal.

In the embodiment, the industrial personal computer is used for generating the terahertz pulse signal according to the digital signal, and generating and displaying a waveform diagram of the terahertz pulse signal; the industrial personal computer is also used for analyzing and processing the oscillogram of the terahertz pulse signal so as to obtain the terahertz spectrum and the imaging information of the object to be treated, and can generate and display the terahertz image of the object to be treated corresponding to the spectrogram and the imaging information of the terahertz spectrum.

Step S203, analyzing the terahertz spectrum and the imaging information of the object to be treated, and identifying the area to be treated of the object to be treated.

In specific application, the industrial personal computer can compare the acquired terahertz spectrum and imaging information of the object to be treated with the terahertz spectrum and imaging information of the healthy object, analyze the difference between the cells and tissues of the object to be treated and the cells and tissues of the healthy object, acquire the change characteristics of the cells and tissues of the object to be treated and the healthy object in terms of composition and structure, and identify and mark the area to be treated of the object to be treated according to the difference and the change characteristics. The region to be treated refers to a diseased region that has a large difference from cells and tissues of a healthy subject and needs to be treated.

And step S204, controlling the injection device to inject a preset dose of photothermal agent into the area to be treated.

In specific application, the industrial personal computer identifies and marks a region to be treated and then transmits a corresponding instruction to the injection device, the injection device is used for identifying and determining the region to be treated under the control of the industrial personal computer, and then the photothermal reagent with a preset dosage is injected. The industrial personal computer can send a dose adjusting instruction to the injection device so as to control the injection device to adjust the size of the preset dose. The preset dosage can be set according to actual needs.

And S205, controlling the laser emitting mechanism to radiate pulse laser to the area to be treated, and carrying out photo-thermal treatment on the area to be treated.

In this embodiment, the laser emission mechanism is used for radiating pulse laser to the region to be treated that has injected the photothermal agent under the control of industrial computer, treats the region of treating and carries out the photothermal therapy. The industrial personal computer can send a laser parameter adjusting instruction to the laser emission mechanism so as to control the laser emission mechanism to adjust parameters such as wavelength, light power and focusing position of the pulse laser. The parameters of the laser pulses can be set according to the actual requirements.

Step S206, in the process of carrying out photothermal therapy on the region to be treated, the terahertz spectrum and the imaging information of the object to be treated are synchronously acquired, and the effect of the photothermal therapy is monitored.

In specific application, in the process of controlling the laser emission mechanism to radiate pulse laser to perform photothermal therapy on the region to be treated, the industrial personal computer can execute the steps S201 and S202 in real time to synchronously acquire the terahertz spectrum and the imaging information of the region to be treated (or only the terahertz spectrum and the imaging information of the region to be treated) and analyze the terahertz spectrum and the imaging information of the region to be treated, mainly compare the terahertz spectrum and the imaging information of the region to be treated with the terahertz spectrum and the imaging information of the healthy object, analyze the difference between the cells and tissues of the region to be treated and the cells and tissues of the healthy object, and acquire the change characteristics of the cells and tissues of the region to be treated and the healthy object in terms of composition and structure, so that the effect of photothermal therapy is monitored. The smaller the variability, the better the photothermal treatment.

And S207, feeding back and adjusting parameters of the pulse laser, the preset dosage and the duration of the photothermal therapy according to the effect of the photothermal therapy.

In specific application, when the effect of photothermal therapy reaches the expected effect, the industrial personal computer can control the laser emitting mechanism to stop radiating pulse laser, namely, the photothermal therapy is stopped; when the effect of the photothermal therapy does not reach the expected effect, the industrial personal computer can adjust the parameters of the pulse laser, the size of the preset dosage and the duration of the photothermal therapy, and continue the photothermal therapy until the effect of the photothermal therapy reaches the expected effect.

In the embodiment, the industrial personal computer controls the laser emitting mechanism to emit the detection light and radiate the terahertz wave to the object to be treated, generates the micro-current signal according to the detection light and the terahertz wave reflected by the object to be treated and processes the micro-current signal into the digital signal, so that the industrial personal computer can generate the terahertz pulse signal according to the digital signal, acquire the terahertz spectrum and the imaging information of the object to be treated according to the terahertz pulse signal, analyze the terahertz spectrum and the imaging information of the object to be treated, identify the area to be treated of the object to be treated, and realize preoperative marking of the area to be treated; the injection device is controlled by the industrial personal computer to inject a preset dose of photothermal reagent into the area to be treated, and the laser emission mechanism is controlled to radiate pulse laser to the area to be treated, so that photothermal treatment can be carried out on the area to be treated; the terahertz spectrum and the imaging information of the object to be treated are synchronously acquired by the industrial personal computer in the process of performing photothermal treatment on the area to be treated, the effect of the photothermal treatment is monitored, and intraoperative monitoring of the object to be treated can be realized; the post-operation tracking of the object to be treated can be realized through the industrial personal computer according to the effect feedback adjustment pulse laser of the photothermal treatment, the size of the preset dosage and the duration of the photothermal treatment, the target identification and the image monitoring and treatment of the region to be treated can be realized simultaneously, the cooperative action is good, the structure is simple, the cost is low, no external interference factor exists, and the high-efficiency, accurate and multifunctional practical application requirements can be met.

Example two

As shown in fig. 3, in the present embodiment, the laser emitting mechanism 2 in the first embodiment includes a double-pulse laser 21, a beam splitter 22, a terahertz radiator 23, a bias voltage module 24, a terahertz detector 25, and a lock-in amplifier module 26;

the double-pulse laser 21 is electrically connected with the industrial personal computer 1, the bias voltage module 24 is electrically connected with the terahertz radiator 23 and the industrial personal computer 1, and the lock-in amplifier module 26 is electrically connected with the terahertz detector 25 and the industrial personal computer 1.

As shown in fig. 4, based on the photothermal treatment system 100 shown in fig. 3, in the present embodiment, the step S201 includes:

step S401, controlling the double-pulse laser to emit first pulse laser; the beam splitter is used for splitting the first pulse laser into pump light and probe light, the pump light is radiated to the terahertz radiator, and the probe light is radiated to the terahertz detector;

step S402, carrying out frequency modulation on the bias voltage module to control the bias voltage module to apply bias voltage to the terahertz radiator; the terahertz radiator is used for generating a photon-generated carrier under the excitation of the pump light and radiating terahertz waves to an object to be treated under the drive of the bias voltage, and the terahertz detector is used for generating a micro-current signal according to the detection light and the terahertz waves reflected by the object to be treated;

s403, controlling the phase-locked amplifier module to amplify and collect the micro-current signal to obtain a digital signal;

step S205 specifically includes:

and controlling the double-pulse laser to radiate second pulse laser to the area to be treated, and carrying out photothermal treatment on the area to be treated.

In specific application, the double-pulse laser can simultaneously emit two beams of mutually independent pulse laser lasers according to actual needs, namely a first pulse laser and a second pulse laser, and the industrial personal computer can control the double-pulse laser to adjust the wavelength and the light power of the two beams of pulse laser.

In particular applications, the beam splitter may be a beam splitter, a prism-type beam splitter, or a cube-type beam splitter. After the first pulse laser beam is split by the beam splitter, one part of the first pulse laser beam is reflected, and the other part of the first pulse laser beam is transmitted. The pump light is a pulse laser beam transmitted by the beam splitter, and the probe light is a pulse laser beam reflected by the beam splitter; alternatively, the pump light is a pulse laser beam reflected by the beam splitter, and the probe light is a pulse laser beam transmitted by the beam splitter.

The beam splitter 22 is exemplarily shown in fig. 3 as a beam splitter, the pump light is a pulse laser beam transmitted by the beam splitter, and the probe light is a pulse laser beam reflected by the beam splitter.

In a specific application, the terahertz radiator comprises a terahertz radiation antenna, and the terahertz detector comprises a terahertz detection antenna.

In a specific application, the bias voltage module can be implemented by any bias voltage device or circuit. The industrial personal computer can provide a modulation frequency for the bias voltage module, and modulates the frequency of the bias voltage to control the bias voltage module to apply the modulated bias voltage to the terahertz radiator. The terahertz radiator is used for generating photon-generated carriers under the excitation of pump light and radiating modulated terahertz waves through the terahertz radiation antenna under the drive of modulated bias voltage.

In specific application, the terahertz detector is used for detecting detection light and terahertz waves reflected by an object to be treated through the terahertz detection antenna, generating a micro-current signal and sending the micro-current signal to the phase-locked amplifier module.

In specific application, the lock-in amplifier module is used for amplifying and collecting micro-current signals generated by the terahertz detector under the control of the industrial personal computer to obtain digital signals.

In one embodiment, the lock-in amplifier module comprises a preamplifier, a lock-in amplifier and an ADC data acquisition card;

the preamplifier is electrically connected with the terahertz detector, the lock-in amplifier is electrically connected with the preamplifier and the ADC data acquisition card, and the ADC data acquisition card is electrically connected with the industrial personal computer;

and the weak current signal sequentially passes through the preamplifier, the lock-in amplifier and the ADC data acquisition card to obtain a digital signal.

In specific application, the amplification factor of the preamplifier, the phase resolution and the frequency resolution of the lock-in amplifier and the data acquisition precision of the ADC data acquisition card can be set according to actual requirements.

As shown in fig. 5, in the present embodiment, the injection device 3 in the first embodiment includes a controller 31, a support trunk 32, a robot arm 33, and a syringe 34 and a camera 35 provided at a free end of the robot arm 33, the syringe 34 is used for carrying a photothermal reagent, and the controller 31 is used for electrically connecting with the industrial personal computer 1, the support trunk 32, the robot arm 33, and the camera 35.

As shown in fig. 6, based on the photothermal treatment system 100 shown in fig. 3 or 5, in the present embodiment, the step S204 includes:

step S601, sending a camera starting instruction to a controller according to a region to be treated; the controller is used for controlling the camera to be started according to the camera starting instruction, the camera is used for identifying and positioning the area to be treated after the camera is started, and the controller is also used for sending the positioning result of the camera to the industrial personal computer;

step S602, sending a moving instruction to the controller according to the camera positioning result sent by the controller; the controller is also used for controlling the supporting trunk and the mechanical arm to move according to the moving instruction, so that the needle tube is positioned to the area to be treated and the photothermal reagent with the preset dosage is injected to the area to be treated.

In a Specific Application, the controller may be a Central Processing Unit (CPU), other general purpose Processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), a Field Programmable Gate Array (FPGA) or other Programmable logic device, a discrete Gate or transistor logic device, a discrete hardware component, or the like. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like. The controller is used for controlling the working states of the supporting trunk, the mechanical arms and the camera under the control of the industrial personal computer.

In a specific application, the support torso is placed on the ground for movement on the ground under the control of the controller and serves as a support for the robotic arm. The mechanical arm is used for carrying the needle tube and the camera to move in a three-dimensional space under the control of the controller. The syringe with the proper volume and the camera with the proper type can be selected according to actual needs.

In one embodiment, the support torso comprises a slidable base and a cradle, the robotic arm comprises N rotating wheels and N limbs;

the slidable base and the N rotating guide wheels are electrically connected with the controller, the bracket and the controller are arranged on the slidable base, the 1 st rotating guide wheel in the N rotating guide wheels is arranged on the bracket, the ith rotating guide wheel in the N rotating guide wheels is connected with the (i-1) th limb joint and the ith limb joint in the N limb joints, and one end, away from the bracket, of the N limb joint is a free end of the mechanical arm;

wherein N is more than or equal to i and more than or equal to 1, and N and i are integers.

In specific application, the bottom of the slidable base is provided with a plurality of sliding rollers, so that the supporting trunk can slide on the ground. The bracket can be set to any shape and size according to actual needs. The mechanical arm can be formed by selecting a proper number of rotating guide wheels and limb sections according to actual needs.

As shown in fig. 5, the exemplary illustrated support torso 32 includes a slidable base 321 and a support frame 322, and the robotic arm 33 includes 3

rotating guide wheels

331, 332, and 333 and 3

limbs

334, 335, and 336;

the bottom of slidable base 321 is provided with 8 slip rollers, support 322 and controller 31 are provided with in slidable base 321, rotatory guide pulley 331 is provided with in support 322, rotatory guide pulley 331 is connected with limb segment 334, rotatory guide pulley 332 is connected with limb segment 334 and limb segment 335, rotatory guide pulley 333 is connected with limb segment 335 and limb segment 336, the one end that limb segment 336 kept away from support 322 is the free end of arm 32.

In the embodiment, the mechanical arm is designed in a bionic mode by taking the arm of a person as a reference, and flexible use of the mechanical arm is guaranteed to the greatest extent. Taking the arm and its joints as reference, the whole mechanical arm is composed of three limbs, corresponding to the upper arm, the lower arm and the hand of the person. Each limb joint is connected through a rotating guide wheel, and each rotating guide wheel can rotate 360 degrees, so that the mechanical arm can rotate to the maximum degree and can be flexibly used; in addition, the head-tail connection structure between the rotary guide wheel and the limb sections enables each limb section to move up and down and left and right in a two-dimensional space, and the height of the mechanical arm can be conveniently adjusted. When the rotating guide wheel adopts a universal wheel, each limb joint can move in a three-dimensional space. The camera is carried to the free end of arm for treat the treatment area and discern and fix a position, the controller of being convenient for adjusts whole injection device's position, makes the needle tubing move to best injection position, so that treat the treatment area and implement accurate light and heat reagent injection, the controller can be under the control of industrial computer according to treating the size and the treatment effect in treatment area, adjusts the injection dosage of light and heat reagent, realizes treating the regional accurate ration injection of treating.

It should be understood that, the sequence numbers of the steps in the foregoing embodiments do not imply an execution sequence, and the execution sequence of each process should be determined by its function and inherent logic, and should not constitute any limitation to the implementation process of the embodiments of the present invention.

EXAMPLE III

As shown in fig. 7, in this embodiment, the laser emitting mechanism 2 in the second embodiment further includes an optical delay line system 27, a first off-axis parabolic mirror 28, a second off-axis parabolic mirror 29 and a focusing lens 20;

the optical delay line system 27 is electrically connected with the industrial personal computer 1 and is used for carrying out optical delay on the pump light under the control of the industrial personal computer 1;

the first off-axis parabolic mirror 28 is used for focusing the terahertz waves radiated by the terahertz radiator 23 to the object to be treated;

the second off-axis parabolic mirror 29 is used for focusing the terahertz waves reflected by the object to be treated to the first incident surface of the terahertz detector 25;

the focusing lens 20 is used to focus the second pulsed laser light to the area to be treated.

In specific application, specific structures and types of the optical delay system, the first off-axis parabolic mirror, the second off-axis parabolic mirror and the focusing lens can be selected according to actual needs.

In this embodiment, the optical delay system is a controllable optical delay system, and the time of optical delay can be adjusted under the control of the industrial personal computer. The first off-axis parabolic mirror and the second off-axis parabolic mirror each include two concave mirrors. The focusing lens is mounted on the three-dimensional guide rail, the three-dimensional guide rail is electrically connected with the industrial personal computer, and the three-dimensional guide rail is used for controlling the focusing lens to move in a three-dimensional space under the control of the industrial personal computer so as to focus the second pulse laser to a region to be treated.

In one embodiment, the laser emission mechanism further comprises at least one first reflecting mirror, at least one second reflecting mirror, at least one third reflecting mirror, at least one fourth reflecting mirror, and a first optical attenuator and a second optical attenuator which are electrically connected with the industrial personal computer;

the at least one first reflecting mirror is arranged between the beam splitter and the incident surface of the optical delay system and used for reflecting the pump light to the incident surface of the optical delay system;

the at least one second reflecting mirror is arranged between the emergent surface of the optical delay system and the incident surface of the terahertz radiator and is used for reflecting the pump light after optical delay to the incident surface of the terahertz radiator;

the at least one third reflector is arranged between the beam splitter and the second incidence surface of the terahertz detector and used for reflecting the detection light to the second incidence surface of the terahertz detector;

the at least one fourth reflector is arranged between the second emitting end of the double-pulse laser and the incident surface of the focusing lens and used for reflecting the second pulse laser to the incident surface of the focusing lens;

the first optical attenuator is arranged between the first emitting end of the double-pulse laser and the beam splitter and is used for attenuating the first pulse laser under the control of the industrial personal computer; or the first optical attenuator is arranged between the beam splitter and the incident surface of the optical delay system and used for attenuating the pumping light under the control of the industrial personal computer; or the first optical attenuator is arranged between the emergent surface of the optical delay system and the incident surface of the terahertz radiator and is used for attenuating the optically delayed pump light under the control of the industrial personal computer;

the second optical attenuator is arranged between a second transmitting end of the double-pulse laser and the incident surface of the focusing lens and used for attenuating the second pulse laser under the control of the industrial personal computer.

As shown in fig. 7, the exemplary laser emitting mechanism 2 further includes 2

first mirrors

41 and 42, 1

second mirror

43, 2

third mirrors

44 and 45, 3

fourth mirrors

46, 47 and 48, and a first optical attenuator 51 and a second optical attenuator 52 electrically connected to the industrial personal computer 1;

2 first mirrors 41 and 42 are disposed between the beam splitter 22 and the incident surface of the optical delay system 27, for reflecting the pump light to the incident surface of the optical delay system 27;

the 1 second reflecting mirror 43 is arranged between the emergent surface of the optical delay system 27 and the incident surface of the terahertz radiator 23, and is used for reflecting the pump light after optical delay to the incident surface of the terahertz radiator 23;

2 third mirrors 44 and 45 are disposed between the beam splitter 22 and the first incident surface of the terahertz detector 25, and are used for reflecting the detection light to the first incident surface of the terahertz detector 25;

the 3

fourth mirrors

46, 47, and 48 are disposed between the output end of the second optical attenuator 52 and the incident surface of the focusing lens 20, and are configured to reflect the second pulsed laser light attenuated by the second optical attenuator 52 to the incident surface of the focusing lens 20;

the first optical attenuator 51 is arranged between the first emission end of the double-pulse laser 21 and the beam splitter 22;

the second optical attenuator 52 is disposed between the second emission end of the double pulse laser 21 and the fourth mirror 46.

In a specific application, the first incident surface and the second incident surface of the terahertz detector can be the same surface.

It should be understood that the laser emitting mechanism provided in the above embodiments may further include an optical parameter adjusting device such as a collimating lens, a beam expanding (beam shrinking) lens group, a polarization state controller, etc., and only the most central components in the laser emitting mechanism are shown in the above embodiments. In specific application, components of the laser emitting mechanism are added, deleted and replaced according to actual needs.

Example four

As shown in fig. 8, in this embodiment, the industrial personal computer 1 in the first embodiment, the second embodiment, or the third embodiment includes: a processor 10, a memory 11, a display 12, and a computer program 13, such as a photothermal therapy program, stored in the memory 11 and executable on the processor 10. The processor 10, when executing the computer program 13, implements the steps in the various photothermal treatment method embodiments described above, such as the steps S201 to S207 shown in fig. 2.

Illustratively, a computer program may be partitioned into one or more modules/units that are stored in the memory and executed by the processor to implement the present invention. The one or more modules/units may be a series of computer program instruction segments capable of performing specific functions, and the instruction segments are used for describing the execution process of the computer program in the industrial personal computer.

As shown in fig. 8, in the present embodiment, the computer program 13 is divided into a first control module 131, an imaging module 132, an identification module 133, a second control module 134, a third control module 135, a monitoring module 136 and a regulation module 137, and each module has the following specific functions:

the first control module 131 is used for controlling the laser emitting mechanism to emit detection light, radiate terahertz waves to an object to be treated, generate micro-current signals according to the detection light and the terahertz waves reflected by the object to be treated, and process the micro-current signals into digital signals;

an imaging module 132, configured to generate a terahertz pulse signal according to the digital signal, and obtain a terahertz spectrum and imaging information of the object to be treated according to the terahertz pulse signal;

the identification module 133 is configured to analyze the terahertz spectrum and the imaging information of the object to be treated, and identify a region to be treated of the object to be treated;

a second control module 134 for controlling the injection device to inject a preset dose of photothermal agent into the region to be treated;

a third control module 135, configured to control the laser emission mechanism to radiate pulsed laser to the region to be treated, so as to perform photothermal treatment on the region to be treated;

the monitoring module 136 is configured to synchronously acquire the terahertz spectrum and the imaging information of the object to be treated during photothermal treatment of the region to be treated, and monitor the effect of the photothermal treatment;

and the adjusting module 137 is used for adjusting the parameters of the pulse laser, the size of the preset dosage and the duration of the photothermal therapy according to the effect feedback of the photothermal therapy.

In one embodiment, the first control module includes:

the control unit is used for controlling the double-pulse laser to emit first pulse laser; the beam splitter is used for splitting the first pulse laser into pump light and probe light, the pump light is radiated to the terahertz radiator, and the probe light is radiated to the terahertz detector;

the modulation unit is used for carrying out frequency modulation on the bias voltage module so as to control the bias voltage module to apply bias voltage to the terahertz radiator; the terahertz radiator is used for generating a photon-generated carrier under the excitation of the pump light and radiating terahertz waves to an object to be treated under the drive of the bias voltage, and the terahertz detector is used for generating a micro-current signal according to the detection light and the terahertz waves reflected by the object to be treated;

the signal processing unit is used for amplifying and collecting the micro-current signal through the lock-in amplifier module to obtain a digital signal;

and the third control module is used for controlling the double-pulse laser to radiate second pulse laser to the area to be treated, and carrying out photothermal treatment on the area to be treated.

In one embodiment, the second control module comprises:

the first sending unit is used for sending a camera starting instruction to the controller according to the area to be treated; the controller is used for controlling the camera to be started according to the camera starting instruction, the camera is used for identifying and positioning the area to be treated after the camera is started, and the controller is also used for sending a positioning result of the camera to the industrial personal computer;

the second sending unit is used for sending a moving instruction to the controller according to the positioning result of the camera sent by the controller; the controller is further used for controlling the supporting trunk and the mechanical arm to move according to the moving instruction, so that the needle tube is positioned to the area to be treated, and a preset dose of photothermal reagent is injected to the area to be treated.

In a particular application, an industrial personal computer may include, but is not limited to, a processor, a memory, and a display screen. Those skilled in the art will appreciate that fig. 8 is merely an example of an industrial computer, and does not constitute a limitation of an industrial computer, and may include more or fewer components than those shown, or some components in combination, or different components, for example, the industrial computer may also include input and output devices, network access devices, buses, etc.

In particular applications, the processor may be a central processing unit, but may also be other general purpose processors, digital signal processors, application specific integrated circuits, field programmable gate arrays or other programmable logic devices, discrete gate or transistor logic, discrete hardware components, and the like. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.

In a specific application, the storage may be an internal storage unit of the industrial personal computer, such as a hard disk or a memory of the industrial personal computer. The memory may also be an external storage device of the industrial personal computer, such as a plug-in hard disk equipped on the industrial personal computer, a Smart Media Card (SMC), a Secure Digital (SD) Card, a Flash memory Card (Flash Card), and the like. The memory may also include both an internal storage unit of the industrial personal computer and an external storage device. The memory is used for storing the computer program and other programs and data required by the industrial personal computer. The memory may also be used to temporarily store data that has been output or is to be output.

It will be apparent to those skilled in the art that, for convenience and brevity of description, only the above-mentioned division of the functional units and modules is illustrated, and in practical applications, the above-mentioned function distribution may be performed by different functional units and modules according to needs, that is, the internal structure of the apparatus is divided into different functional units or modules to perform all or part of the above-mentioned functions. Each functional unit and module in the embodiments may be integrated in one processing unit, or each unit may exist alone physically, or two or more units are integrated in one unit, and the integrated unit may be implemented in a form of hardware, or in a form of software functional unit. In addition, specific names of the functional units and modules are only for convenience of distinguishing from each other, and are not used for limiting the protection scope of the present application. The specific working processes of the units and modules in the system may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.

In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and reference may be made to the related descriptions of other embodiments for parts that are not described or illustrated in a certain embodiment.

Those of ordinary skill in the art will appreciate that the various illustrative elements and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware or combinations of computer software and electronic hardware. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the implementation. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present invention.

In the embodiments provided in the present invention, it should be understood that the disclosed apparatus/terminal device and method may be implemented in other ways. For example, the above-described embodiments of the apparatus/terminal device are merely illustrative, and for example, the division of the modules or units is only one logical division, and there may be other divisions when actually implemented, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form.

The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.

In addition, functional units in the embodiments of the present invention may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.

The integrated modules/units, if implemented in the form of software functional units and sold or used as separate products, may be stored in a computer readable storage medium. Based on such understanding, all or part of the flow of the method according to the embodiments of the present invention may also be implemented by a computer program, which may be stored in a computer-readable storage medium, and when the computer program is executed by a processor, the steps of the method embodiments may be implemented. Wherein the computer program comprises computer program code, which may be in the form of source code, object code, an executable file or some intermediate form, etc. The computer-readable medium may include: any entity or device capable of carrying the computer program code, recording medium, usb disk, removable hard disk, magnetic disk, optical disk, computer Memory, Read-Only Memory (ROM), Random Access Memory (RAM), electrical carrier wave signals, telecommunications signals, software distribution medium, and the like. It should be noted that the computer readable medium may contain content that is subject to appropriate increase or decrease as required by legislation and patent practice in jurisdictions, for example, in some jurisdictions, computer readable media does not include electrical carrier signals and telecommunications signals as is required by legislation and patent practice.

The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments can be modified, or some technical features can be equivalently replaced; such modifications and substitutions do not substantially depart from the spirit and scope of the embodiments of the present invention, and are intended to be included within the scope of the present invention.

Claims

1. A photothermal therapy system based on terahertz imaging is characterized by comprising an industrial personal computer, a laser emitting mechanism and an injection device, wherein the laser emitting mechanism and the injection device are electrically connected with the industrial personal computer;

the industrial computer comprises:

2. The terahertz imaging based photothermal therapy system of claim 1, wherein the laser emitting mechanism comprises a double pulse laser, a beam splitter, a terahertz radiator, a bias voltage module, a terahertz detector, and a lock-in amplifier module;

the double-pulse laser is electrically connected with the industrial personal computer, the bias voltage module is electrically connected with the terahertz radiator and the industrial personal computer, and the lock-in amplifier module is electrically connected with the terahertz detector and the industrial personal computer;

the first control module includes:

3. The terahertz imaging based photothermal therapy system of claim 2, wherein the laser emitting mechanism further comprises an optical delay line system, a first off-axis parabolic mirror, a second off-axis parabolic mirror, and a focusing lens;

the optical delay line system is electrically connected with the industrial personal computer and is used for carrying out optical delay on the pump light under the control of the industrial personal computer;

the first off-axis parabolic mirror is used for focusing the terahertz waves radiated by the terahertz radiator to the object to be treated;

the second off-axis parabolic mirror is used for focusing the terahertz waves reflected by the object to be treated to a first incident surface of the terahertz detector;

the focusing lens is used for focusing the second pulse laser to the area to be treated.

4. The terahertz imaging based photothermal therapy system of claim 1, wherein the injection device comprises a controller, a support trunk, a mechanical arm, and a needle tube and a camera disposed at a free end of the mechanical arm, the needle tube for carrying the photothermal agent, the controller being electrically connected to the industrial personal computer, the support trunk, the mechanical arm, and the camera;

the second control module includes:

5. An industrial personal computer, includes memory, treater, display screen and storage in the memory and can be in the computer program of operation on the treater, its characterized in that, the industrial personal computer is connected with laser emission mechanism and injection device electricity, realize following step when the treater execution computer program:

6. The industrial personal computer of claim 5, wherein the laser emitting mechanism comprises a double-pulse laser, a beam splitter, a terahertz radiator, a bias voltage module, a terahertz detector and a lock-in amplifier module;

the method comprises the following steps of controlling a laser emission mechanism to emit detection light and radiate terahertz waves to an object to be treated, generating micro-current signals according to the detection light and the terahertz waves reflected by the object to be treated, and processing the micro-current signals into digital signals, wherein the method comprises the following steps:

controlling the double-pulse laser to emit first pulse laser; the beam splitter is used for splitting the first pulse laser into pump light and probe light, the pump light is radiated to the terahertz radiator, and the probe light is radiated to the terahertz detector;

performing frequency modulation on the bias voltage module to control the bias voltage module to apply bias voltage to the terahertz radiator; the terahertz radiator is used for generating a photon-generated carrier under the excitation of the pump light and radiating terahertz waves to an object to be treated under the drive of the bias voltage, and the terahertz detector is used for generating a micro-current signal according to the detection light and the terahertz waves reflected by the object to be treated;

amplifying and collecting the micro-current signal through the lock-in amplifier module to obtain a digital signal;

control laser emission mechanism to treat treatment area radiation pulse laser, right treat that treatment area carries out light and heat treatment, include:

7. The industrial personal computer of claim 6, wherein the laser emitting mechanism further comprises an optical delay line system, a first off-axis parabolic mirror, a second off-axis parabolic mirror, and a focusing lens;

8. The industrial personal computer of claim 7, wherein the laser emission mechanism further comprises at least one first mirror, at least one second mirror, at least one third mirror, at least one fourth mirror, and a first optical attenuator and a second optical attenuator electrically connected to the industrial personal computer;

9. The industrial personal computer of claim 5, wherein the injection device comprises a controller, a support trunk, a mechanical arm, a needle tube and a camera, the mechanical arm is arranged on the support trunk, the needle tube and the camera are arranged at free ends of the mechanical arm, the needle tube is used for carrying the photothermal reagent, and the controller is electrically connected with the industrial personal computer, the support trunk, the mechanical arm and the camera;

according to the area to be treated, controlling the injection device to inject a preset dosage of photothermal agent to the area to be treated, comprising:

sending a camera starting instruction to the controller according to the area to be treated; the controller is used for controlling the camera to be started according to the camera starting instruction, the camera is used for identifying and positioning the area to be treated after the camera is started, and the controller is also used for sending a positioning result of the camera to the industrial personal computer;

sending a moving instruction to the controller according to the camera positioning result sent by the controller; the controller is further used for controlling the supporting trunk and the mechanical arm to move according to the moving instruction, so that the needle tube is positioned to the area to be treated, and a preset dose of photothermal reagent is injected to the area to be treated.