CN110251182A - A kind of umbellate form tissue plug - Google Patents
A kind of umbellate form tissue plug Download PDFInfo
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- CN110251182A CN110251182A CN201910514204.XA CN201910514204A CN110251182A CN 110251182 A CN110251182 A CN 110251182A CN 201910514204 A CN201910514204 A CN 201910514204A CN 110251182 A CN110251182 A CN 110251182A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12154—Coils or wires having stretch limiting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of umbellate form tissue plugs, are combined by degradable medical polyurethane and Mg-Zn based alloy, the performance of umbellate form the tissue plug fixing intensity with higher and absorption of degrading in one month, are the closure products of a function admirable.
Description
Technical field
The present invention relates to a kind of umbellate form tissue plug and its in the application of medical field, the implantation material is by degradable medical
Polyurethane and magnesium alloy are combined, and are had and are preferably blocked mechanical property and absorbability.
Background technique
Tissue plug is widely used in the repairing of tissue defect, especially blood vessel block field, blood vessel blocking device type compared with
It is more, domestic at present there are commonly Angioseal to block, Perelose is blocked, Boomerang is blocked, Starclose is blocked etc.,
Wherein Angioseal can absorb plugging device and is clinically most widely used, and Angioseal plugging device anchor for fixing is by butterfly
The PLGA bar of butterfly knot shape is made, and degradation time 2-3 months or so, vascular puncture position is caused inflammation occur after implantation, short
It cannot be grown completely in phase, not can be carried out secondary puncture operation, be clinically highly desirable to a degrade in 1 month thus and absorb
Blood vessel block product.
Certain fixing intensity is needed in plugging device implantation process, in case senior general's plugging device anchor of exerting oneself is broken,
Angioseal can absorb plugging device the case where being pulled off during use just it has been reported that so, higher fixation is strong
It with the biocompatibility of human body is the important indicator for measuring product quality superiority and inferiority after degree and implantation.
Ideal blood vessel blocking device should have good biocompatibility and degradability, not cause collective's immunological rejection anti-
It answers, there is plasticity and certain mechanical strength, good surface-active is conducive to cell adherence, growth, increment.
We pass through the Comparison Study of a variety of biomaterials, are increased by redesigning the shape of plugging device anchor fixed strong
Degree, research selects suitable biomaterial to increase the biocompatibility of product, by studying test repeatedly, finally uses magnesium zinc
Alloy and degradable medical compound polyurethane material have developed umbellate form plugging device of the invention, test by internal and external test, umbrella
The fixing intensity of type plugging device is higher than butterfly structure, and biocompatibility is better than commercially available Angioseal plugging device, is hopeful to face
Bed provides a performance more preferably product.
Summary of the invention
Goal of the invention of the invention is to provide a kind of umbellate form tissue plug, and fixing intensity is higher than butterfly structure, biofacies
Capacitive is better than commercially available Angioseal plugging device, is hopeful to provide a performance more preferably product for clinic.
The invention discloses a kind of umbellate form tissue plug, the umbrella frame of the umbellate form tissue plug is by absorbable medical
Metal material is made, and umbrella cloth film made of degradable medical polyurethane of the umbellate form tissue plug is made,
Wherein, the weight ratio range of absorbable medical metal material and degradable medical polyurethane is 0.1-5.0:0.5, preferably
0.2-3.0:0.5；The weight range of the umbrella frame of umbellate form tissue plug is 0.05-2.0g.
A kind of umbellate form tissue plug of the present invention, wherein absorbable medical metal material includes ferrous alloy, magnesium
One of alloy and zinc-containing alloy, preferably magnesium base alloy, one of more preferable high purity magnesium, Mg-Zn based alloy, magnesium zinc system close
Gold refers specifically to Mg-Zn series, can add the rare earth element of the microelement and good biocompatibility in human body to improve magnesium conjunction
Gold corrosion resistance and intensity, such as Mn(manganese), selenium (Se), molybdenum (Mo), chromium (Cr), cobalt (Co), Nd(neodymium), Y(yttrium), Sr
(strontium), such as: Mg-Zn-Zr-RE system (such as Mg-Zn-Zr-Y system), Mg-Zn-Mn system, Mg-Zn-Mn-Se system, preferably: Mg-Zn-
Zr series, wherein Zn content is 2.0-6.5%, and Zr content is 0.3-0.9%, and the control of remaining alloy impurity is 0.5%, following content
For, for example international trade mark ZK40(Zn content is 3.5-4.0%, and Zr content is 0.5%, and magnesium is surplus), ZK60(Zn content is 5.0-
6.0%, Zr content be 0.5%, magnesium is surplus), ZK60A(Zn content be 5.0-6.0%, Zr content be 0.7%, magnesium is surplus) or
ZK61(Zn content is 5.0-6.0%, and Zr content is 0.6-0.8%, and impurity≤0.3%, magnesium is surplus)；Add the height of Mn and rare earth
Strength magnesium alloys, such as: Mg-Zn-Zr-Mn(Zn content is 3.5-4.0%, and Zr content is 0.5-0.7%, and Mn content is 0.5-
1.0%, magnesium is surplus), ZM2(Zn content is 3.5-5.0%, and Zr content is 0.5-0.7%, and RE content is 0.5-0.7%, and magnesium is remaining
Amount)；Antibacterial magnesium alloy: ZM7(Zn content be 7.5-9.0%, Ag0.6-1.2%, Zr content be 0.5-1.0%, impurity less than 0.3%,
Magnesium is surplus).
A kind of umbellate form tissue plug of the present invention, wherein film made of degradable medical polyurethane be selected from by GA, LA,
The propylene glycol of PDO, CL, 1,3,1,4 butanediols, 1,5 pentanediols and PEG(200,400,600) one or more of altogether
The composition of polymer made of poly- soft segment, the degradable medical polyurethane that lysine polyisocyanates is hard section, number-average molecular weight model
Enclose is 20,000-20 ten thousand.Lysine polyisocyanates is selected from lysine diisocyanate fat acid esters, lysine triisocyanate fat
Acid esters, wherein aliphatic ester carbon atom number is 1,2,3,4,5,6,7,8, and preferably carbon atom number is 1 or 2, specially lysine two
Ethyl isocyanate, lysine diisocyanate methyl ester, lysine triisocyanate ethyl ester, three methyl isocyanate of lysine；PDO is embedding
Section copolymer caused by di-alcohol, wherein di-alcohol include ethylene glycol, polyethylene glycol (200,300,400,600,
1000), one or both of propylene glycol, butanediol, pentanediol, hexylene glycol, heptandiol and ethohexadiol.
A kind of umbellate form tissue plug of the present invention can be used to prepare the anchor of blood vessel blocking device, and preparation method can
To be: magnesium alloy plate pressure being rolled into umbrella skeleton, perforates on frame rod, absorbable suture is fixed, by degradable medical
Interior be placed outside in grinding tool that polyurethane film is wrapped in umbrella skeleton forms, and is heated to after 60-150 degree vacuum molding both obtaining.
Magnesium alloy plate pressure is rolled into umbrella skeleton, perforates on frame rod, absorbable suture is fixed, by degradable doctor
It is wrapped in be placed outside in grinding tool in umbrella skeleton with polyurethane film and be formed, be heated to after 60-150 degree vacuum molding both obtaining.
Magnesium alloy plate pressure is rolled into umbrella skeleton, frame rod wire drawing or drilling are for fixing suture, by degradable doctor
It is squeezed into grinding tool with melt polyurethane, frame rod and umbrella skeleton is wrapped in grinding tool and is formed, be heated to the molding of 60-150 degree
Both.
Magnesium alloy plate pressure is rolled into umbrella frame configuration, frame rod wire drawing or drilling can be dropped for fixing suture
Solution medical polyurethane solvent dissolution is configured to the solution of 15-30%, squeezes into grinding tool, frame rod and umbrella skeleton are wrapped in
It is formed in grinding tool, is heated to 60-150 degree and vacuumizes that solvent had been evaporated into 60ppm or less both.
A kind of umbellate form tissue plug of the present invention, it is characterised in that can be with appendix drug, stem cell, various activity
Molecule, polypeptide, collagen and active medicine, such as antiproliferative, anti-migration, anti-angiogenesis, anti-inflammatory, anti-inflammatory, cell growth
Inhibit, cytotoxicity and or anti-thrombosis activity agent be selected from including following substance group: sirolimus, everolimus,
Elidel, growth hormone release inhibiting hormone, tacrolimus, roxithromycin, daunomycin, ascosin, Ba Foluo mycin, Abboticine,
Medecamycin, caspase, canavalin, Clarith, troleandomycin, folimycin, cerivastatin, Simvastatin,
Lovastatin, Fluvastatin, rosuvastatin, Atorvastatin, Pravastatin, Pitavastatin, catharanthine, vincristine, length
Fields for spring sowing are pungent, vinorelbine, Etoposide, Teniposide, Nimustine, Carmustine, Luo Mositing, cyclophosphamide, female do not take charge of
Spit of fland, alkeran, ifosfamide, Trofosfamide, Chlorambucil, bendamustine, Dacarbazine, busulfan, procarbazine, song
Ao Shufan, Temozolomide, phosphinothioylidynetrisaziridine, Doxorubicin, Aclarubicin, epirubicin, mitoxantrone, idarubicin, bleomycin,
Mitomycin C, dactinomycin D, methopterin, fludarabine, fludarabine -5 '-dihydrogen orthophosphate, Cladribine, mercapto are fast
Purine, thioguanine, cytarabine, fluorouracil, gemcitabine, capecitabine, polyenoid taxol, carboplatin, cis-platinum, oxaliplatin
One of or composition, developer can also be added.
Organic solvent of the present invention is selected from toluene, paraxylene, decane, isoamyl acetate, hexane, benzene, dichloromethane
Alkane, chloroform, cyclohexanone, ketone, dimethylformamide, heptane, dimethylamino formamide, tetrahydrofuran, petroleum ether, diformazan
One or both of sulfoxide, ethylene glycol terephthalate, preferably tetrahydrofuran, decane, isoamyl acetate, hexane, dichloro
One or both of methane, chloroform, cyclohexanone, dimethylformamide and heptane, preferably methylene chloride, three chloromethanes
One or both of alkane, DMF, DMSO tetrahydrofuran or ethyl acetate.
Implantation material of the present invention can also add other natural or polymer materials, such as collagen (soluble glue
It is former), PVP, Sodium Hyaluronate, zinc hyaluronate, PEG series, glycerol, propylene glycol, butanediol, pentanediol, various it can be used for body
The emulsifier being implanted into is (such as: phosphatide and modified phospholipid (such as soybean lecithin, egg yolk lecithin of various PC contents), tween
Serial (20,40,80), Families of poloxamers) polylactide, polyglycolide, polyactide and polyglycolide copolymer (PLGA
(LA:GA ratio is 1-3:1), such as: the ratio of LA:GA is 75:25；65:35 and 50:50), polyethylene glycol series, poly- pair
Dioxa cyclohexanone and its copolymer (PPDO, PLA-PDO) are poly- to dioxa cyclohexanone (PPDO), polytrimethylene carbonic acid
Ester, polylactic acid-trimethylene carbonate copolymer, magnesium alloy-trimethylene carbonate copolymer, polyglycolic acid, poly- cream
Acid-co-glycolic acid, polyether-ether-ketone, polyvinylpyrrolidone and/or polyethylene glycol, poly- valerolactone, in poly- ε-last of the ten Heavenly stems
Ester, poly- ε-caprolactone, polyhydroxybutyrate, poly butyric ester, poly- hydroxyl valerate, poly butyric ester-copolymerization-valeric acid
Ester, poly- (1,3- dioxane -2- ketone), gathers to dioxane poly- (Isosorbide-5-Nitrae-dioxane -2,3- diketone)
Hexanone, polyanhydride (such as poly-maleic anhydride), poly- hydroxyl-metacrylate, fibrin, polybutylcyanoacrylate, magnesium
Alloy dimethylacrylate, magnesium alloy butyl propyleneglycol acid esters, comes from the pure and mild oligomerization of few magnesium alloy two at poly- β-maleic acid
Multi-block polymer, polyethylene glycol and the polybutylene terephthalate of dioxanone glycol)), poly- pivalolactone, poly- second
Alkyd carbonate, poly- (γ-ethyl glutamate), poly- (DTH- iminocarbonic ester), gathers magnesium alloy-glycolide
(DTE- copolymerization-DT- carbonic ester), poly- (bisphenol-A-iminocarbonic ester), polyorthoester, polyglycolic acid trimethyl carbonic acid
Ester, poly- trimethyl carbonate, poly- iminocarbonic ester, poly- (N- vinyl)-pyrrolidones, polyvinyl alcohol, polyesteramide, ethyl alcohol
Change polyester, polyphosphate, polyphosphazene, poly- [to carboxyphenoxy) propane], poly- hydroxypentanoic acid, polyanhydride, polyethylene glycol oxide-oxygen
Change propylene, flexibel polyurethane, in main chain with polyurethane, the polyether ester (such as polyethylene glycol oxide), polyolefin of amino acid residue
Nontoxic plasticizer, tributyl citrate (TBC), second can also be added in one of oxalate, polyorthoester and its copolymer
Acyl tributyl citrate (ATBC), trioctyl trimellitate (TOTM), tri trimellitate (810) ester, trimellitic acid glyceryl ester, equal benzene four
Sour four monooctyl esters, diethylene glycol dibenzoate, diethylene glycol dibenzoate, dipropylene glycol dibenzoate, terephthalic acid (TPA) two are pungent
One or more of ester, dioctyl terephthalate, dihexyl sebacate, epoxidized soybean oil.
Wherein Detailed description of the invention 3 of the present invention, umbellate form bar fixator and 4, frame rod, can be absorbable medical suture,
It can be magnesium alloy materials, preferably magnesium alloy.
The supporting tool that umbellate form blood vessel blocking device of the present invention blocks the tool and commercially available Angioseal plugging device that need is similar
Seemingly, without separately arranging.
Detailed description of the invention:
Fig. 1, similar blood vessel blocking device anchor shape；
One of structural schematic diagram of umbellate form plugging device anchor in Fig. 2, the present invention；
Another structural schematic diagram of umbellate form plugging device anchor in Fig. 3, the present invention.
1, degradable medical polyurethane film；2, magnesium alloy umbellate form bar；3, umbellate form bar fixator；4, suture or frame rod；
5, magnesium alloy plate；6, inside and outside connecting hole.
Specific embodiment is exemplified below:
Embodiment 1, the anchor that different shape blood vessel blocking device is prepared using different technique
(1) magnesium alloy plate (Mg-Zn alloy, trade mark ZK60) class commercialized product Angioseal plugging device blood vessel is rolled into block
The shape (as shown in Figure 1) of the anchor of device bores several inside and outside connecting holes 6, by degradable medical on degradable medical polyurethane film 1
Polyurethane bar and film package magnesium alloy anchor are placed in grinding tool and form, and are heated to after 80-150 degree vacuum molding both obtaining.
(2) magnesium alloy thin slice engraving pressure is rolled into umbrella frame configuration (as shown in Figure 2), by degradable medical polyurethane
Film 1, magnesium alloy umbellate form bar 2, umbellate form bar fixed frame 3 and suture or frame rod 4 form, and degradable medical polyurethane film is wrapped up
It is placed outside in grinding tool and forms in umbrella skeleton, be heated to after 60-150 degree vacuum molding both obtaining.
(3) magnesium alloy thin slice engraving pressure is rolled into umbrella frame configuration (as shown in Figure 3), by degradable medical polyurethane
Film is dissolved in chloroformic solution, is configured to the solution of 20% concentration, is cast in the grinding tool for placing umbrella skeleton and is formed, is heated to
After 60-150 degree vacuum molding both.
The product physical property comparative study that embodiment 2, Different Preparation obtain
Fixing intensity test: sample, sample diameter 1cm are prepared by the method in embodiment 1, magnesium alloy skeleton gross mass is
0.2g, degradable medical polyurethane gross mass are 0.15g, and the shape being processed into Fig. 1,2,3, each shape takes three systems respectively
Product fix product with suture, as a result as follows with the fixing intensity (N) of universal testing machine test article:
Be comprehensively compared: the shape of Fig. 3 design of the present invention designs fixing intensity highest.
The product muscular grafting research that embodiment 3, Different Preparation obtain
Respectively each 2 of four kinds of samples in Example 2 (sample number into spectrum according to being numbered in embodiment 2, respectively 1,2,3,4),
Take new zealand rabbit 4 (number of animals is consistent with sample number into spectrum), clean hair is shaved in rear leg, after each implantation in left and right 1,1 month
It puts to death, as a result reaction condition after observation implantation see the table below:
Conclusion: there is disintegration in commercialized product muscular grafting the latter moon, implantation material, and inflammatory reaction locally occurs in fragmentation,
It is harvested entirely using the implantation of blood vessel blocking device made of degradable medical polyurethane and magnesium-zinc alloy muscle the latter moon interior suction, is not gone out
Existing inflammatory reaction, has compared with commercialized product with better biocompatibility.
Embodiment 4, magnesium alloy and degradable medical weight polyurethane compare the influence of blood vessel blocking device fixing intensity
Shape shown in Fig. 3 is made in the anchor that total weight is 0.35g, adjusts the material of magnesium alloy materials and degradable medical polyurethane
The weight ratio of material measures fixing intensity, and specific experiment result is as follows:
。
Remarks: degradable medical polyurethane is prepared into the thin elliposoidal in thick middle periphery
Conclusion: experimental result shows that magnesium alloy and polyurethane proportional region can satisfy clinical vascular in the range of 0.4-6
The performance requirement of closure, so magnesium alloy of the present invention and polyurethane proportional region are preferred are as follows: 0.2-3.0:0.5.
Claims (9)
1. a kind of umbellate form tissue plug, which is characterized in that the umbrella frame of the umbellate form tissue plug is by absorbable medical gold
Belong to material to be made, the umbrella cloth of the umbellate form tissue plug is made of degradable medical polyurethane.
2. a kind of umbellate form tissue plug according to claim 1, which is characterized in that the umbrella of the umbellate form tissue plug
Skeleton is made of absorbable medical metal material, and the umbrella cloth of the umbellate form tissue plug is made of degradable medical polyurethane,
Wherein the weight ratio range of absorbable medical metal material and degradable medical polyurethane is 0.1-5.0:0.5, umbellate form tissue envelope
The weight range of the umbrella frame of stifled device is 0.05-2.0g.
3. a kind of umbellate form tissue plug according to claim 1, which is characterized in that the absorbable medical metal material
Selected from one of ferrous alloy, magnesium base alloy and zinc-containing alloy.
4. a kind of umbellate form tissue plug according to claim 1, which is characterized in that the degradable medical polyurethane choosing
Free GA, LA, the propylene glycol of PDO, CL, 1,3,1,4 butanediols, 1,5 pentanediols and PEG(200,400,600) one of or
The degradable medical polyurethane that polymer made of two or more copolymerization forms soft segment, lysine polyisocyanates is hard section, number
Average molecular weight range is 20,000-20 ten thousand.
5. a kind of umbellate form tissue plug according to claim 3, which is characterized in that the lysine polyisocyanates choosing
From lysine diisocyanate fat acid esters, lysine triisocyanate aliphatic ester, wherein aliphatic ester carbon atom number be 1,2,
3,4,5,6,7,8, preferably carbon atom number be 1 or 2, specially lysine diisocyanate ethyl ester, lysine diisocyanate methyl ester, rely
Propylhomoserin triisocyanate ethyl ester, three methyl isocyanate of lysine；PDO block copolymer is caused by di-alcohol, wherein glycol
Substance include ethylene glycol, polyethylene glycol (200,300,400,600,1000), propylene glycol, butanediol, pentanediol, hexylene glycol,
One or both of heptandiol and ethohexadiol；Magnesium base alloy refers specifically to Mg-Zn series, can add the micro member in human body
The rare earth element of element and good biocompatibility is to improve the corrosion resistance and intensity of magnesium alloy, such as Mn(manganese), selenium (Se), molybdenum
(Mo), chromium (Cr), cobalt (Co), Nd(neodymium), Y(yttrium), Sr(strontium), such as: Mg-Zn-Zr-RE system (such as Mg-Zn-Zr-Y system), Mg-
Zn-Mn system, Mg-Zn-Mn-Se system, preferably: Mg-Zn-Zr series, wherein Zn content is 2.0-6.5%, and Zr content is 0.3-
0.9%, the control of remaining alloy impurity is in 0.5%, following content, for example international trade mark ZK40(Zn content is 3.5-4.0%, and Zr contains
Amount be 0.5%, magnesium is surplus), ZK60(Zn content be 5.0-6.0%, Zr content be 0.5%, magnesium is surplus), ZK60A(Zn content
For 5.0-6.0%, Zr content is 0.7%, and magnesium is surplus) or ZK61(Zn content be 5.0-6.0%, Zr content is 0.6-0.8%, miscellaneous
Matter≤0.3%, magnesium are surplus)；The high-strength magnesium alloy of Mn and rare earth are added, such as: Mg-Zn-Zr-Mn(Zn content is 3.5-
4.0%, Zr content are 0.5-0.7%, and Mn content is 0.5-1.0%, and magnesium is surplus), ZM2(Zn content is 3.5-5.0%, Zr content
For 0.5-0.7%, RE content is 0.5-0.7%, and magnesium is surplus)；Antibacterial magnesium alloy: ZM7(Zn content is 7.5-9.0%, Ag0.6-
1.2%, Zr content are 0.5-1.0%, and for impurity less than 0.3%, magnesium is surplus).
6. a kind of umbellate form tissue plug according to claim 1, which is characterized in that can be used for preparing blood vessel blocking device
Anchor, preparation method are as follows: magnesium alloy plate pressure being rolled into umbrella frame configuration, degradable medical polyurethane film is wrapped in umbrella
It is placed outside in shaping grinding apparatus in shape skeleton, is heated to after 60-150 degree vacuum molding both obtaining.
7. a kind of umbellate form tissue plug according to claim 1, which is characterized in that can be used for preparing blood vessel blocking device
Anchor and frame rod, preparation method are as follows: magnesium alloy plate pressure being rolled into umbrella skeleton, is perforated on frame rod, by absorbable seam
Zygonema is fixed, and degradable medical polyurethane film is wrapped in umbrella skeleton and is placed outside in shaping grinding apparatus, 60-150 is heated to
It spends after vacuum molding and both obtained.
8. a kind of umbellate form tissue plug according to claim 1, which is characterized in that can be used for preparing blood vessel blocking device
Anchor and frame rod, preparation method are as follows: magnesium alloy plate pressure being rolled into umbrella skeleton, frame rod wire drawing or drilling are for fixing
Suture is squeezed into grinding tool by degradable medical melt polyurethane or with the solution that organic dissolution is dissolved into 15-30%, by skeleton
Bar and umbrella skeleton wrap up molding and in grinding tool, are heated to the molding of 60-150 degree, drain dissolution and both obtain.
9. a kind of umbellate form tissue plug described in -4 according to claim 1, which is characterized in that can with appendix drug, stem cell,
Various bioactive molecules, polypeptide, collagen and active medicine, for example, antiproliferative, anti-migration, anti-angiogenesis, anti-inflammatory, anti-inflammatory,
Cell growth inhibition, cytotoxicity and or anti-thrombosis activity agent be selected from including following substance group: sirolimus,
Everolimus, Elidel, growth hormone release inhibiting hormone, tacrolimus, roxithromycin, daunomycin, ascosin, Ba Foluo mycin, second
Amber erythromycin, medecamycin, caspase, canavalin, Clarith, troleandomycin, folimycin, cerivastatin,
Simvastatin, Lovastatin, Fluvastatin, rosuvastatin, Atorvastatin, Pravastatin, Pitavastatin, catharanthine, length
Spring new alkali, eldisine, vinorelbine, Etoposide, Teniposide, Nimustine, Carmustine, Luo Mositing, ring phosphinylidyne
Amine, Estramustine, alkeran, ifosfamide, Trofosfamide, Chlorambucil, bendamustine, Dacarbazine, busulfan, third
Carbonohydrazides, Treosulfan, Temozolomide, phosphinothioylidynetrisaziridine, Doxorubicin, Aclarubicin, epirubicin, mitoxantrone, idarubicin,
Bleomycin, mitomycin C, dactinomycin D, methopterin, fludarabine, fludarabine -5 '-dihydrogen orthophosphate, carat are bent
Shore, mercaptopurine, thioguanine, cytarabine, fluorouracil, gemcitabine, capecitabine, polyenoid taxol, carboplatin, cis-platinum,
One of oxaliplatin or composition can also add developer.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117137543A (en) * | 2023-11-01 | 2023-12-01 | 山东瑞安泰医疗技术有限公司 | Degradable plugging device and preparation method and application thereof |
Citations (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101234041A (en) * | 2008-01-31 | 2008-08-06 | 上海交通大学 | Atrial septal defect plugging device knitted by degradable material |
| CN101304693A (en) * | 2005-11-11 | 2008-11-12 | 奥特鲁泰克有限公司 | Plugging device for plugging auricle of heart and method for manufacturing the same |
| CN101410064A (en) * | 2006-03-24 | 2009-04-15 | 奥特鲁泰克有限公司 | Occlusion instrument and method for its production |
| CN201227295Y (en) * | 2008-07-28 | 2009-04-29 | 吉林科罗纳多医疗器械有限公司 | Blood vessel blockage device |
| WO2009097968A2 (en) * | 2008-02-05 | 2009-08-13 | Smith & Nephew Orthopaedics Ag | Open-pore biocompatible surface coating for an implant, method for producing the same, and use thereof |
| KR20110059214A (en) * | 2009-11-27 | 2011-06-02 | 한국과학기술연구원 | Coating method for stents or biomedical implants by electrospray |
| WO2011156193A2 (en) * | 2010-06-07 | 2011-12-15 | Mangiardi Eric K | Device and method for management of aneurism, perforation and other vascular abnormalities |
| CN203677142U (en) * | 2013-12-20 | 2014-07-02 | 西安组织工程与再生医学研究所 | Double umbrella type self-expansion absorbable amplatzer occluder |
| CN104490502A (en) * | 2014-12-25 | 2015-04-08 | 周玉杰 | Biological absorbable membrane-covered stent for treating coronary artery perforation |
| CN204246182U (en) * | 2014-11-22 | 2015-04-08 | 常州乐奥医疗科技有限公司 | A kind of novel umbrella occluder for left auricle |
| CN204379353U (en) * | 2014-12-31 | 2015-06-10 | 山东省立医院 | A kind of multi-functional blood vessel haemostat |
| CN204411042U (en) * | 2014-12-25 | 2015-06-24 | 周玉杰 | A kind of bioabsorbable membrane overlay film frame being used for the treatment of arteria coronaria perforation |
| CN204723106U (en) * | 2015-06-02 | 2015-10-28 | 中国人民解放军第四军医大学 | A kind of stopper gets involved retracting device |
| CN204839631U (en) * | 2015-07-07 | 2015-12-09 | 上海形状记忆合金材料有限公司 | Muscular ventricular septal defect plugging device |
| CN105169496A (en) * | 2015-09-30 | 2015-12-23 | 苏州纳晶医药技术有限公司 | Biodegradable stent composite |
| CN205459211U (en) * | 2016-02-19 | 2016-08-17 | 杭州启明医疗器械有限公司 | Thrombus filter |
| CN106063949A (en) * | 2015-09-30 | 2016-11-02 | 圆容生物医药无锡有限公司 | Fixing composite material in a kind of high-strength degradable bone |
| CN106859722A (en) * | 2017-03-17 | 2017-06-20 | 广州新诚生物科技有限公司 | A kind of sacculus left atrial appendage occlusion device |
| CN206738807U (en) * | 2017-04-05 | 2017-12-12 | 南京狄诺尼科技有限责任公司 | A kind of umbrella rib type pipeline plug |
| CN107802311A (en) * | 2017-11-20 | 2018-03-16 | 乐普（北京）医疗器械股份有限公司 | A kind of Wholly-degradable vessel sealing structure |
| CN207785226U (en) * | 2017-03-17 | 2018-08-31 | 广州新诚生物科技有限公司 | A kind of sacculus left atrial appendage occlusion device |
| CN109077759A (en) * | 2018-10-23 | 2018-12-25 | 昆明市延安医院 | A kind of porous atrial septal defect plugging device |
| CN109503797A (en) * | 2018-10-28 | 2019-03-22 | 凯斯蒂南京医疗器械有限公司 | A kind of medical degradable polyurethane and application thereof with antibacterial activity |
| US20190134257A1 (en) * | 2016-09-28 | 2019-05-09 | Terumo Corporation | Polymer particles |
| CN109758193A (en) * | 2019-01-22 | 2019-05-17 | 陈金凤 | A kind of atrial septal defect plugging device |
-
2019
- 2019-06-14 CN CN201910514204.XA patent/CN110251182A/en active Pending
Patent Citations (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101304693A (en) * | 2005-11-11 | 2008-11-12 | 奥特鲁泰克有限公司 | Plugging device for plugging auricle of heart and method for manufacturing the same |
| CN101410064A (en) * | 2006-03-24 | 2009-04-15 | 奥特鲁泰克有限公司 | Occlusion instrument and method for its production |
| CN101234041A (en) * | 2008-01-31 | 2008-08-06 | 上海交通大学 | Atrial septal defect plugging device knitted by degradable material |
| WO2009097968A2 (en) * | 2008-02-05 | 2009-08-13 | Smith & Nephew Orthopaedics Ag | Open-pore biocompatible surface coating for an implant, method for producing the same, and use thereof |
| CN201227295Y (en) * | 2008-07-28 | 2009-04-29 | 吉林科罗纳多医疗器械有限公司 | Blood vessel blockage device |
| KR20110059214A (en) * | 2009-11-27 | 2011-06-02 | 한국과학기술연구원 | Coating method for stents or biomedical implants by electrospray |
| WO2011156193A2 (en) * | 2010-06-07 | 2011-12-15 | Mangiardi Eric K | Device and method for management of aneurism, perforation and other vascular abnormalities |
| CN203677142U (en) * | 2013-12-20 | 2014-07-02 | 西安组织工程与再生医学研究所 | Double umbrella type self-expansion absorbable amplatzer occluder |
| CN204246182U (en) * | 2014-11-22 | 2015-04-08 | 常州乐奥医疗科技有限公司 | A kind of novel umbrella occluder for left auricle |
| CN104490502A (en) * | 2014-12-25 | 2015-04-08 | 周玉杰 | Biological absorbable membrane-covered stent for treating coronary artery perforation |
| CN204411042U (en) * | 2014-12-25 | 2015-06-24 | 周玉杰 | A kind of bioabsorbable membrane overlay film frame being used for the treatment of arteria coronaria perforation |
| CN204379353U (en) * | 2014-12-31 | 2015-06-10 | 山东省立医院 | A kind of multi-functional blood vessel haemostat |
| CN204723106U (en) * | 2015-06-02 | 2015-10-28 | 中国人民解放军第四军医大学 | A kind of stopper gets involved retracting device |
| CN204839631U (en) * | 2015-07-07 | 2015-12-09 | 上海形状记忆合金材料有限公司 | Muscular ventricular septal defect plugging device |
| CN105169496A (en) * | 2015-09-30 | 2015-12-23 | 苏州纳晶医药技术有限公司 | Biodegradable stent composite |
| CN106063949A (en) * | 2015-09-30 | 2016-11-02 | 圆容生物医药无锡有限公司 | Fixing composite material in a kind of high-strength degradable bone |
| CN205459211U (en) * | 2016-02-19 | 2016-08-17 | 杭州启明医疗器械有限公司 | Thrombus filter |
| US20190134257A1 (en) * | 2016-09-28 | 2019-05-09 | Terumo Corporation | Polymer particles |
| CN106859722A (en) * | 2017-03-17 | 2017-06-20 | 广州新诚生物科技有限公司 | A kind of sacculus left atrial appendage occlusion device |
| CN207785226U (en) * | 2017-03-17 | 2018-08-31 | 广州新诚生物科技有限公司 | A kind of sacculus left atrial appendage occlusion device |
| CN206738807U (en) * | 2017-04-05 | 2017-12-12 | 南京狄诺尼科技有限责任公司 | A kind of umbrella rib type pipeline plug |
| CN107802311A (en) * | 2017-11-20 | 2018-03-16 | 乐普（北京）医疗器械股份有限公司 | A kind of Wholly-degradable vessel sealing structure |
| CN109077759A (en) * | 2018-10-23 | 2018-12-25 | 昆明市延安医院 | A kind of porous atrial septal defect plugging device |
| CN109503797A (en) * | 2018-10-28 | 2019-03-22 | 凯斯蒂南京医疗器械有限公司 | A kind of medical degradable polyurethane and application thereof with antibacterial activity |
| CN109758193A (en) * | 2019-01-22 | 2019-05-17 | 陈金凤 | A kind of atrial septal defect plugging device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117137543A (en) * | 2023-11-01 | 2023-12-01 | 山东瑞安泰医疗技术有限公司 | Degradable plugging device and preparation method and application thereof |
| CN117137543B (en) * | 2023-11-01 | 2024-02-02 | 山东瑞安泰医疗技术有限公司 | Degradable plugging device and preparation method and application thereof |
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