CN110236740A - A kind of artificial joint prosthesis with bionic function - Google Patents

A kind of artificial joint prosthesis with bionic function Download PDF

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Publication number
CN110236740A
CN110236740A CN201910159554.9A CN201910159554A CN110236740A CN 110236740 A CN110236740 A CN 110236740A CN 201910159554 A CN201910159554 A CN 201910159554A CN 110236740 A CN110236740 A CN 110236740A
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China
Prior art keywords
joint prosthesis
artificial joint
layer
porous
compacted zone
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Pending
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CN201910159554.9A
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Chinese (zh)
Inventor
刘铁龙
胡一为
白广建
高欣
王静
刘永刚
陈广辉
汪洋
刘戈
曹佳实
刘伟波
杨家祥
董连峰
信保全
吕凯
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Shanghai Changzheng Hospital
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Shanghai Changzheng Hospital
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Publication of CN110236740A publication Critical patent/CN110236740A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Composite Materials (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Geometry (AREA)
  • Physics & Mathematics (AREA)
  • Prostheses (AREA)
  • Urology & Nephrology (AREA)

Abstract

The invention discloses a kind of artificial joint prosthesis with bionic function, belong to the field of medical instrument technology, it is made of porous layer, compacted zone and embeding layer.The artificial joint prosthesis, which passes through, utilizes specific nanometer hydroxyapatite/polyamide 66 material, in conjunction with the special designing of porous layer of the present invention, compacted zone and embeding layer, such as, the design of porous layer central hole structure simultaneously cultivates cartilage cell's layer on porous structure, articular cartilage face is formed, to realize motor function；For another example, by adding macroporous structure in compacted zone to fill self bone tissue, so that artificial joint prosthesis is integrated with bone tissue " growth "；To which the artificial joint prosthesis with bionic function be prepared, the complication of prosthetic loosening sinking is reduced, the service life of joint prosthesis is extended.

Description

A kind of artificial joint prosthesis with bionic function
Technical field
The invention belongs to the field of medical instrument technology, are related to a kind of artificial joint prosthesis with bionic function.
Background technique
With the economic development and improvement of people's living standards, prosthetic replacement has been widely used in clinic and has taken Good clinical effectiveness was obtained, effective treatment method of all kinds of ultimate joint diseases is acknowledged as.However, pushing away with the time Move, the prosthetic loosening that is generated by this operation sinks etc., and complication also become increasingly conspicuous, seriously affected operation clinical efficacy and The quality of life of patient.Once these adverse consequences occurs in patient, generally requires patient and carry out revision procedure treatment, this not only increases The operation pain and medical expense of patient are added, and the clinical efficacy after overhauling also can not show a candle to initial surgery ideal.
Currently, the artificial joint material clinically applied mainly includes medical metal material and medical macromolecular materials.It closes Section prosthese is made of medical metal material, the development of novel titanium-based metal in recent years and the improvement of surface coated treatment technology, The wearability and mechanical property of metal artificial's articular prosthesis are improved, biological safety is also improved.However, current business There are many problems for the artificial joint prosthesis of change, and it is low and biological that aseptic loosening, wearability deficiency, fatigue strength such as easily occurs Mechanical compatibility difference etc..Firstly, the combination between existing alloy material and bone tissue is realized by fibr tissue, can not be formed always Good synosteosis interface.Secondly, the elasticity modulus of elasticity modulus (E=100~200GPa) and skeleton of alloy material (E=10~40GPa) gap great disparity, therefore stress-shielding effect will inevitably occur after Using prosthesis.Stress shielding will So that the strain of implant surrounding bone is reduced, secondary osteoporosis, sclerotin are thinning, pulp cavity expands, and are that prosthese-bone interface fine motion occurs With the postoperative fracture even basic reason of abarticulation.
In addition, joint spacer is made of medical macromolecular materials, widely used is ultra-high molecular weight polyethylene (UHMWPE).The good wearability of UHMWPE, low frictional properties and self-lubricating property become the constituent of joint spacer, group Friction combination, which is padded, at metal-UHMWPE greatly improves the length of service of joint prosthesis.However, UHMWPE advanced stage wears sternly Weight, often generates a large amount of abrasive dusts.The abrasion of UHMWPE not only directly destroys stability of joint, but also produces big weight northylen clast Particle.Debris particles become third party's particle of frictional interface, and cutting scratches frictional interface surface repeatedly, and has aggravated UHMWPE Abrasion.More importantly joint motion causes a large amount of clasts including polyethylene particle and bone cement particle to generate, Macrophage and foreign-body giant cell in Periprosthetic limitans will be activated, promotes the release of the cell factors such as TNF-α.Study table Bright, these cell factors can activate osteoclast and fibroblast, and Periprosthetic bone resorption, bone dissolution and fiber is caused to increase It is raw, implantation material-bone tissue interface bond strength is destroyed, prosthese is promoted to loosen.And prosthetic loosening aggravates to wear, and is formed Abrasion-loosening-abrasion vicious circle.Therefore it needs by appropriate material and cleverly to design and prepares one kind with bionical The artificial joint prosthesis of function solves artificial joint prosthesis and loosens the complication of sinking, and biological fixing joint prosthese simultaneously reduces The frictional dissipation of articular surface extends the service life of prosthese.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of artificial joint prosthesis with bionic function.
Nanometer hydroxyapatite/polyamide 66 (nHA/PA66) is the bioceramic class material of novel bionic, is had excellent Biological safety, bioactivity and with the matched mechanical property of skeleton.Artificial vertebral body, intervertebral has been made in nHA/PA66 Fusion device and filling material of bone etc. are widely used in clinic.Experimental results demonstrate this bioactive materials have good bone Integration ability can be integrated with body bone tissue.Prosthesis handle made of nHA/PA66 (i.e. embeding layer) can well be tied with human body bone It closes, realizes bone tissue vascularization, avoid Using prosthesis position that fine motion occurs, be conducive to early clinic healing.Currently, porous nHA/ PA66 mature preparation process, porosity and pore-size are controllable, have good biomechanical property.Its intensity and elasticity modulus It is similar to skeleton, it can apply to the reconstruction (i.e. compacted zone) of bearing position bone.And stress-shielding effect is weak after being implanted into, Be conducive to the growth for being implanted into bone tissue, reduce the incidence of bone resorption and loosening.
Tissue engineering bracket of the porous nHA/PA66 (i.e. porous layer) as cultured chondrocytes has biocompatibility good Good advantage, and aperture and controlled porosity can be used as a kind of ideal artificial synthesized timbering material.Compound transforming growth factor Good cartilage-derived growth microenvironment can be provided with the porous support of a variety of growth factors such as bone morphogenetic protein, induction cartilage is thin The cartilage seed cells such as born of the same parents, mesenchymal stem cell proliferation, differentiation, secrete cartilage cell epimatrix, and final acquisition joint is soft Bone face.The realization of articular cartilage face can rebuild joint motions function, and avoid the generation of wear particle, reduce aseptic inflammation And prosthetic loosening, obtain service life longer than metal artificial joint.
The present invention provides a kind of artificial joint prosthesis with bionic function, it is by porous layer, compacted zone and insertion Layer composition.
Further, the material of the porous layer, compacted zone and embeding layer is nanometer hydroxyapatite/polyamide 66.
Further, the porous layer has porous structure.
Further, the porosity of the porous structure is 75% or more, preferably 85%~90%.
Further, the internal diameter in the hole of the porous structure is 100~800 μm, preferably 200~350 μm；It is described porous 200~300 μm of the internal diameter average out in the hole of structure.
Further, the hole of the porous structure is perforation.
Further, the porous layer further includes articular cartilage face.
Further, the articular cartilage face is formed by cultivating cartilage cell's layer on porous layer.
Further, the length of the porous layer is 3~5mm.
Further, the compacted zone includes two groups of mutually perpendicular macroporous structures；The diameter of the macropore be 6~ 10mm。
Further, the length of the compacted zone is 10~25cm.
Further, the embeding layer includes the hole that 4 diameters are 4~8mm.
Further, the length of the embeding layer is 10cm.
The present invention provides a kind of artificial joint prosthesis with bionic function, which passes through using specific Nanometer hydroxyapatite/polyamide 66 material, in conjunction with the special designing of porous layer of the present invention, compacted zone and embeding layer, for example, The design of porous layer central hole structure simultaneously cultivates cartilage cell's layer on porous structure, articular cartilage face is formed, to realize fortune Dynamic function；For another example, by adding macroporous structure in compacted zone to fill self bone tissue, so that artificial joint prosthesis and surrounding bone Tissue " growth " is integrated, it can be achieved that the fusion of good bone tissue, autologous bone tissue vascularization and more preferable support function；To make It is standby to have obtained the artificial joint prosthesis with bionic function, the complication of prosthetic loosening sinking is reduced, joint prosthesis is extended Service life.
Meanwhile the present invention prepares artificial joint prosthesis using 3D printing technique, utilizes 3D printing technique " customized " Individuation implantation material matched with subjects bones it is more accurate, suffering limb functional rehabilitation faster, often without by tasting repeatedly in surgical procedure The prosthese for trying various models avoids aggravating local trauma, and can be obviously shortened operating time.
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention The technology realized all belongs to the scope of the present invention.
Detailed description of the invention
Fig. 1 is the front schematic view of artificial joint prosthesis of the present invention.
Fig. 2 is the stereoscopic schematic diagram of artificial joint prosthesis of the present invention.
Fig. 3 is the shape of joint prosthesis made of actual fabrication.
Specific embodiment
Raw material, equipment used in the specific embodiment of the invention are known product, are obtained by purchase commercial product.
Nanometer hydroxyapatite/polyamide 66 material: Sichuan Guona Technology Co., Ltd..
The artificial joint prosthesis of the present invention of embodiment 1
One, the structure of artificial joint prosthesis of the present invention
There is the present invention artificial joint prosthesis of bionic function to be made of porous layer, compacted zone and embeding layer.Such as Fig. 1- Shown in Fig. 3, wherein Fig. 1 and Fig. 2 illustrates the internal structure of positional relationship between different layers, proportionate relationship and each layer, Fig. 3 indicates the shape of joint prosthesis made of actual fabrication, and the size of manufactured joint prosthesis can be according to the specific feelings of patient Condition is adjusted.
1, porous layer
Porous layer is articular surface contact portion, is designed as porous structure, material therefor is nanometer hydroxyapatite/polyamide 66.The porosity of the porous structure is 85%~90%, and the internal diameter in hole is 200~350 μm, porous layer with a thickness of 3~5mm
Cartilage cell is inoculated into porous layer, is placed in thin by the present invention by cultivating cartilage cell's layer on porous structure It is cultivated in born of the same parents' culture solution, articular cartilage face is formed, to realize motor function.Cultural method is to be inoculated with cartilage cell In porous layer surface, its growth and breeding is allowed, and form cartilage cell's layer.
2, compacted zone
Compacted zone is fusion part, and compacted zone length is 10~25cm, specific length range involved according to patient's tumour and Fixed, osteotomy position is the outer 5cm of tumour.The macroporous structure that two groups of mutually perpendicular diameters are 6mm or 8mm is designed, for filling Self bone tissue, it can be achieved that good bone tissue merges and is able to achieve autologous bone tissue vascularization after implanting.Due to self The bone tissue and prosthese formed after bone tissue fusion forms the structure of mutual interlocking, therefore can realize than individual articular prosthesis More preferable support function.Particularly, HA/PA66 used in the present invention has good osteoconductive, can realize biology with bone tissue Property combine, be more advantageous to the firm connection of bone tissue and material, realize support function.
3, embeding layer
Embeding layer length is 10cm, and embeding layer is support fixed part, this part is the design of joint handle portion, with general pass Section is consistent, but adding diameter is fixation hole 4 of 4~8mm, is fixed for outer fixation steel plate.
Two, the preparation of artificial joint prosthesis of the present invention
(1) data import
It will be made of about artificial joint prosthesis porous layer, compacted zone and embeding layer in aforementioned one, and between different layers Positional relationship, the internal structure of proportionate relationship and each layer import 3D printing equipment, form mathematical model；According to patient's thin layer CT scan data, MRI image data, determine the size of joint prosthesis；
It requires to design artificial joint prosthesis according to bone grafting.
(2) 3D printing artificial joint prosthesis
Nanometer hydroxyapatite/polyamide 66 powder raw material is successively melted according to the mathematical model of importing, finally utilizes 3D Artificial joint prosthesis is prepared in printing, and print temperature is 275~280 DEG C.
Illustrate beneficial effects of the present invention below by way of pharmacodynamic experiment.
1 porous layer different pore size size of experimental example cultivates cartilage cell's layer
The artificial joint prosthesis for taking the method for the present invention to prepare, inoculating cell are cultivated.
The experimental results showed that specific porosity and internal diameter are conducive to cultivate in the porous structure of porous layer of the present invention Cartilage cell's layer.
Application of 2 artificial joint prosthesis of experimental example in large segmental bone defect reconstruction
The artificial joint prosthesis for taking the method for the present invention to prepare carries out bone defect reconstruction.
The experimental results showed that cultivating the realization that cartilage cell's layer is conducive to motor function above porous structure of the present invention；It causes The macroporous structure that close layer is added is by filling self bone tissue, so that artificial joint prosthesis and bone tissue " growth " are one Body is, it can be achieved that the fusion of good bone tissue, autologous bone tissue vascularization and more preferable support function.
To sum up, the present invention provides a kind of artificial joint prosthesis with bionic function, which passes through benefit With specific nanometer hydroxyapatite/polyamide 66 material, special in conjunction with porous layer of the present invention, compacted zone and embeding layer is set Meter, for example, the design of porous layer central hole structure and the cultivation cartilage cell layer on porous structure, form articular cartilage face, from And realize motor function；For another example, by adding macroporous structure in compacted zone to fill self bone tissue, so that artificial joint prosthesis Be integrated with bone tissue " growth ", it can be achieved that good bone tissue merge, autologous bone tissue vascularization and more preferably support function Energy；To which the artificial joint prosthesis with bionic function be prepared, the complication of prosthetic loosening sinking is reduced, is extended The service life of joint prosthesis.
Meanwhile the present invention prepares artificial joint prosthesis using 3D printing technique, utilizes 3D printing technique " customized " Individuation implantation material matched with subjects bones it is more accurate, suffering limb functional rehabilitation faster, often without by tasting repeatedly in surgical procedure The prosthese for trying various models avoids aggravating local trauma, and can be obviously shortened operating time.

Claims (10)

1. a kind of artificial joint prosthesis with bionic function, it is characterised in that: it is by porous layer, compacted zone and embeding layer group At.
2. artificial joint prosthesis according to claim 1, it is characterised in that: the porous layer, compacted zone and embeding layer Material is nanometer hydroxyapatite/polyamide 66.
3. artificial joint prosthesis according to claim 1, it is characterised in that: the porous layer has porous structure；It is preferred that Ground, the porosity of the porous structure are 75% or more, preferably 85%~90%.
4. artificial joint prosthesis according to claim 3, it is characterised in that: the internal diameter in the hole of the porous structure is 100 ~800 μm, preferably 200~350 μm；200~300 μm of the internal diameter average out in the hole of the porous structure.
5. artificial joint prosthesis according to claim 3, it is characterised in that: the hole of the porous structure is perforation.
6. artificial joint prosthesis according to claim 1, it is characterised in that: the porous layer further includes articular cartilage face； Preferably, the articular cartilage face is formed by cultivating cartilage cell's layer on porous layer.
7. artificial joint prosthesis according to claim 1, it is characterised in that: the length of the porous layer is 3~5mm.
8. artificial joint prosthesis according to claim 1, it is characterised in that: the compacted zone includes two groups orthogonal Macroporous structure；The diameter of the macropore is 6~10mm；Preferably, the length of the compacted zone is 10~25cm.
9. artificial joint prosthesis according to claim 1, it is characterised in that: the embeding layer include 4 diameters be 4~ The hole of 8mm.
10. preparation method according to claim 1, it is characterised in that: the length of the embeding layer is 10cm.
CN201910159554.9A 2018-03-02 2019-03-04 A kind of artificial joint prosthesis with bionic function Pending CN110236740A (en)

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CN201810175043 2018-03-02

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Citations (6)

* Cited by examiner, † Cited by third party
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