CN110236642A - A kind of bioclastic acquisition method - Google Patents
A kind of bioclastic acquisition method Download PDFInfo
- Publication number
- CN110236642A CN110236642A CN201910559206.0A CN201910559206A CN110236642A CN 110236642 A CN110236642 A CN 110236642A CN 201910559206 A CN201910559206 A CN 201910559206A CN 110236642 A CN110236642 A CN 110236642A
- Authority
- CN
- China
- Prior art keywords
- drive array
- bioclastic
- driver
- sheets
- millimeters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000008676 import Effects 0.000 claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- 239000002872 contrast media Substances 0.000 claims abstract description 4
- 239000003822 epoxy resin Substances 0.000 claims description 12
- 229920000647 polyepoxide Polymers 0.000 claims description 12
- -1 siloxane structure Chemical group 0.000 claims description 9
- 241000209094 Oryza Species 0.000 claims description 4
- 235000007164 Oryza sativa Nutrition 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 4
- 238000005452 bending Methods 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 235000009566 rice Nutrition 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 12
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 11
- 150000003460 sulfonic acids Chemical class 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 210000004204 blood vessel Anatomy 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 229910052697 platinum Inorganic materials 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 239000012279 sodium borohydride Substances 0.000 description 3
- 229910000033 sodium borohydride Inorganic materials 0.000 description 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 150000003058 platinum compounds Chemical class 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical class Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000032594 Vascular Remodeling Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 238000005488 sandblasting Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22079—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with suction of debris
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
- A61B2017/2215—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having an open distal end
Abstract
The present invention relates to life science field, the end of a kind of bioclastic acquisition method, outer sleeve is connected to suction pump by catheter, and suction pump is connected to the interior space of drive array；To contrast agent is added in biotic environment locating for bioclastic capture device, and observed by X-ray production apparatus；Voltage source applies unified positive voltage by six sheets of the Thin cable to driver, so that the import of drive array expands, and drives drive array mobile by catheter, so that more bioclastics enter in drive array；After the bioclastic accumulation in drive array is a certain amount of, voltage source applies unified negative voltage by six sheets of the Thin cable to driver, so that the import of drive array is reduced, so that the bioclastic being located in drive array is not easy to be detached from from drive array；It is closed after opening suction pump 1 second, so that the bioclastic in drive array is sucked pumping from locating biotic environment by catheter.
Description
Technical field
The present invention relates to life science field, it is especially a kind of based on micro-electromechanical technology can in small space into
Row cell and a kind of bioclastic acquisition method of bioclastic acquisition.
Background technique
Blood platelet or other biological fragment in blood vessel, which deposit to blood vessel and will lead to local vascular, to narrow or blocks, and
Cause certain heart diseases, in addition, the thrombus formed in certain openheart surgeries can also cause blood vessel blockage, therefore, it is necessary to
The final stage of operation carries out blood vessel cleaning.Certain prior arts avoid vascular remodeling using the metal pipe holder with aperture plate
Caused blood flow is reduced, but the bioclastic etc. generated in the operating process of bracket is possible to cause blood vessel stifled again
Plug, the method that some other prior art is eluted using drug are also not enough to completely remove bioclastic, a kind of life
Object fragment acquisition method is able to solve problem.
Summary of the invention
To solve the above-mentioned problems, the method for the present invention combines micro-electromechanical technology with the wire-grid structure of special designing, energy
It is enough that efficient cell and bioclastic acquisition are carried out in small space.
The technical scheme adopted by the invention is that:
Bioclastic capture device include outer sleeve, linkage section, driver, four elastic rings, wire-grid structure, catheter,
Suction pump, X-ray production apparatus, Thin cable and voltage source, xyz are that three-dimensional system of coordinate, outer sleeve and linkage section are coaxially glued with epoxy resin
It closes and fixes, driver includes six sheets, and six sheets all have starting point and end, the starting point of six sheets of driver
It is successively fixed in uniform way with the side of linkage section, and arranges and to form a drive array, the central axis of the drive array
Coaxial with outer sleeve, the plane that the end of six sheets of driver is formed is the import of drive array, six sheet difference
It is all connected with voltage source by Thin cable, when voltage source applies different voltages, enables to six sheets that in various degree curved occurs
Curved change has wire-grid structure between adjacent sheet, and wire-grid structure is made of zigzag siloxane structure arranged in parallel, and four
The inside of six sheets in the outside and driver of a elastic ring is bonded by epoxy resin, so that four elastic rings are co-axially mounted
In the inside of drive array, the spacing between adjacent resilient rings is 1 millimeter；Outer sleeve is polyethylene pipe, the outer diameter of outer sleeve
For 6 millimeters, internal diameter be 5 millimeters, length is 10 millimeters；Linkage section is titanium alloy tube, and the outer diameter of linkage section is 5.5 millimeters, internal diameter
It is 4 millimeters for 5 millimeters, length；Six sheets of driver be length be 8 millimeters, width is 1.8 millimeters, micro- with a thickness of 200
The metallic composite of rice；The diameter of Thin cable is 80 microns；Four elastic rings be outer diameter be 5 millimeters, internal diameter is 4.9 millimeters
And it is made of macromolecular material；Wire-grid structure with a thickness of 3 microns, adjacent saw-tooth shape spacing is 20 microns, wire-grid structure
Coefficient of elasticity in the z-direction is 2 ns/m.
A kind of the step of bioclastic acquisition method are as follows:
The end of step 1, outer sleeve is connected to suction pump by catheter, drives so that suction pump is connected to by catheter
The interior space of dynamic device array；
Step 2 to being added contrast agent in biotic environment locating for bioclastic capture device, and passes through X-ray production apparatus and carries out
Observation；
Step 3, voltage source applies unified positive voltage by six sheets of the Thin cable to driver, so that driver
The import of array expands, and drives drive array mobile by catheter, so that more bioclastics enter driver battle array
In column；
Step 4, after the bioclastic in drive array gathers, voltage source is by Thin cable to six of driver
Sheet applies unified negative voltage, so that the import of drive array is reduced, bioclastic is limited in drive array
In space；
Step 5 is closed after opening suction pump 1 second, so that the bioclastic in drive array is taken out by catheter
Sucking pump detaches locating biotic environment.
The beneficial effects of the present invention are:
The method of the present invention is low in cost, easy to operate, high to the collecting efficiency of bioclastic in small space.
Detailed description of the invention
It is further illustrated below with reference to figure of the invention:
Fig. 1 is apparatus of the present invention schematic diagram；
Fig. 2 is apparatus of the present invention perspective view；
Fig. 3 is the partial enlargement diagram of wire-grid structure.
In figure, 1. outer sleeves, 2. linkage sections, 3. drivers, 4. 4 elastic rings, 5. wire-grid structures, 6. catheters.
Specific embodiment
If Fig. 1 is apparatus of the present invention schematic diagram, if Fig. 2 is apparatus of the present invention perspective view, including outer sleeve (1), linkage section
(2), driver (3), four elastic rings (4), wire-grid structure (5), catheter (6), suction pump, X-ray production apparatus, Thin cable and voltage
Source, xyz are three-dimensional system of coordinate, and outer sleeve (1) is polyethylene pipe, and the outer diameter of outer sleeve (1) is 6 millimeters, internal diameter is 5 millimeters, long
Degree is 10 millimeters, and linkage section (2) is titanium alloy tube, and the outer diameter of linkage section (2) is 5.5 millimeters, internal diameter is 5 millimeters, length is 4 millis
Rice, outer sleeve (1) are coaxially adhesively fixed with linkage section (2) with epoxy resin, and driver (3) includes six sheets, six sheets
Be length be 8 millimeters, width is 1.8 millimeters, with a thickness of 200 microns of metallic composites, six sheets all have starting
End and end, side of the starting point of six sheets of driver (3) successively in uniform way with linkage section (2) is fixed, and arranges shape
At a drive array, the central axis of the drive array and outer sleeve (1) coaxially, six sheets of driver (3)
The plane that end is formed is the import of drive array, and six sheets pass through Thin cable respectively and are all connected with voltage source, Thin cable
Diameter is 80 microns, when voltage source applies different voltages, six sheets is enabled to occur different degrees of Bending Deformation, four
The inside of six sheets in the outside and driver (3) of elastic ring (4) is bonded by epoxy resin, so that four elastic rings (4)
It is coaxially installed on the inside of drive array, the spacing between adjacent resilient rings is 1 millimeter, and four elastic rings (4) are outer diameters
It is made by 4.9 millimeters and of 5 millimeters, internal diameter of macromolecular material.
If Fig. 3 is the partial enlargement diagram of wire-grid structure, there are wire-grid structure (5) between adjacent sheet, aperture plate knot
Structure (5) is made of zigzag siloxane structure arranged in parallel, wire-grid structure (5) with a thickness of 3 microns, adjacent saw-tooth shape spacing
It is 20 microns, the coefficient of elasticity of wire-grid structure (5) in the z-direction is 2 ns/m.
Bioclastic capture device includes outer sleeve (1), linkage section (2), driver (3), four elastic rings (4), aperture plates
Structure (5), catheter (6), suction pump, X-ray production apparatus, Thin cable and voltage source, xyz are three-dimensional system of coordinate, outer sleeve (1) and company
It connects section (2) to be coaxially adhesively fixed with epoxy resin, driver (3) includes six sheets, and six sheets all have starting point and end
End, side of the starting point of six sheets of driver (3) successively in uniform way with linkage section (2) is fixed, and is arranged and to be formed one
Drive array, the central axis of the drive array and outer sleeve (1) coaxially, the end shape of six sheets of driver (3)
At plane be drive array import, six sheets pass through Thin cable respectively and are all connected with voltage source, and voltage source applies different
When voltage, enables to six sheets that different degrees of Bending Deformation occurs, there are wire-grid structure (5) between adjacent sheet,
Wire-grid structure (5) is made of zigzag siloxane structure arranged in parallel, outside and driver (3) of four elastic rings (4)
The inside of six sheets is bonded by epoxy resin, so that four elastic rings (4) are coaxially installed on the inside of drive array, phase
Spacing between adjacent elastic ring is 1 millimeter；Outer sleeve (1) is polyethylene pipe, and the outer diameter of outer sleeve (1) is 6 millimeters, internal diameter 5
Millimeter, length are 10 millimeters；Linkage section (2) is titanium alloy tube, and the outer diameter of linkage section (2) is 5.5 millimeters, internal diameter is 5 millimeters, long
Degree is 4 millimeters；Six sheets of driver (3) be length be 8 millimeters, width is 1.8 millimeters, with a thickness of 200 microns of gold
Belong to composite material；The diameter of Thin cable is 80 microns；Four elastic rings (4) be outer diameter be 5 millimeters, internal diameter be 4.9 millimeters and
It is made of macromolecular material；Wire-grid structure (5) with a thickness of 3 microns, adjacent saw-tooth shape spacing is 20 microns, wire-grid structure
(5) coefficient of elasticity in the z-direction is 2 ns/m.
The processing method of driver (3): basic skills is to plate metal platinum layer in perfluorinated sulfonic acid film surface:
The first step carries out sandblasting grinding process to a thickness of 190 microns of perfluorinated sulfonic acid film surface, to increase its surface
Product is subsequently placed in supersonic cleaning machine and is cleaned using deionized water, and then perfluorinated sulfonic acid film is placed in the hydrochloric acid after dilution
In solution, and keep hydrochloric acid solution in boil condition 30 minutes to connect the pollution of perfluorinated sulfonic acid film surface and ion remaval
Rinsed with deionized water, finally, perfluorinated sulfonic acid film is placed in the deionized water boiled 30 minutes, for removing perfluor
The remaining acid of sulfonic acid film surface, and make film expansion；
Second step, main purpose are so that perfluorinated sulfonic acid film immerses perfluorinated sulfonic acid film with ion-exchange capacity
The solution of every milliliter of platinum compounds comprising 2 milligrams of platinum, such as [Pt (NH3)4]C12, 1 milliliter of hydroxide is then added in the solution
Ammonium keeps 10 hours to neutralize solution at room temperature；
Third step, preliminary plated film use reducing agent such as sodium borohydride to reduce the content of platinocyanide cation in film, use
After deionized water is rinsed film, film is placed in 40 C water baths of agitation, 4 millis were then added every 30 minutes
The sodium borohydride of concentration 5% is risen, and is repeated 8 times, in this process, temperature is progressively increased to 60 degrees Celsius, then, is added
40 milliliters of sodium borohydrides simultaneously stir 2 hours under 60 degree celsius temperatures, finally rinse film using deionized water, and film is soaked
1 hour in aqueous hydrochloric acid solution after entering dilution；
4th step, second of plating, continued growth platinum layer is on the platinum layer of original film surface to reduce sheet resistance:
100 milliliters of configuration include the platinum compounds solution of 50 milligrams of platinum, and 2 milliliter 5% of ammonium hydroxide is added in the solution, by film
It immerses in the solution, then every 30 minutes 5 milliliters of 4% hydroxylamine hydrochlorides of addition and 2 milliliters of 10% hydrazine solution, and small 4
When it is interior solution temperature is increased to 60 degrees Celsius, until film surface formed grey metal layer, finally, being neutralized using sodium borohydride
Solution, and film is rinsed using deionized water.
The processing method of wire-grid structure (5): basic skills is that micro-nano knot is prepared in silicone compositions using photolithography method
Structure:
Step 1: in 2 microns of surface of silicon deposition thickness of aluminium layer, using as sacrificial layer；
Step 2: silicone compositions are deposited to aluminium layer surface using spin coating method, with a thickness of 20 microns；
Step 3: covering optical mask plate, the optical mask plate have zigzag structure arranged in parallel, are then exposed to light
Strong is 20 milliwatts/square centimeter ultraviolet light lower 20 seconds；
Step 4: aluminum sacrificial layer is removed using chemical etchant, to obtain the aperture plate knot made of silicone compositions
Structure (5).
Driver (3), wire-grid structure (5) and four elastic ring (4) assembly methods: wire-grid structure (5) is laid in silicon lining
On bottom, then the epoxy resin of uV curable is used to be coated on the inside of six sheets of driver (3), it then will be in six sheets
Side is placed side by side downward on wire-grid structure (5), and being exposed to light intensity is 20 milliwatts/square centimeter ultraviolet light lower 40 seconds, so that
Driver (3) is connect with wire-grid structure (5), next, epoxy resin is coated on the outside of four elastic rings (4), by driver
(3) and wire-grid structure (5) is rolled and is nested on the outside of four elastic rings (4) until epoxy resin solidifies, finally by six sheets
Starting point by epoxy resin be fixed to linkage section (2).
Working principle: device is placed in blood vessel or similar biotic environment, and voltage source is by Thin cable to driver (3)
Six sheets apply unified voltage, in the case that the voltage of application is positive, the end of sheet to deviate from driver battle array
The direction of the central axis of column is bent, so that the import of drive array expands, more bioclastics is enabled to enter driving
In device array；In the case that the voltage of application is negative, the end of sheet is to the direction of the central axis close to drive array
Bending enables to the bioclastic being located in drive array to be not easy from driver so that the import of drive array is reduced
It is detached from array.
A kind of the step of bioclastic acquisition method are as follows:
The end of step 1, outer sleeve (1) is connected to suction pump by catheter, so that suction pump is connected to by catheter
The interior space of drive array；
Step 2 to being added contrast agent in biotic environment locating for bioclastic capture device, and passes through X-ray production apparatus and carries out
Observation；
Step 3, voltage source apply unified positive voltage by six sheets of the Thin cable to driver (3), so that driving
The import of device array expands, and drives drive array mobile by catheter, so that more bioclastics enter driver
In array；
Step 4, after the bioclastic in drive array gathers, voltage source is by Thin cable to the six of driver (3)
A sheet applies unified negative voltage, so that the import of drive array is reduced, bioclastic is limited in drive array
Space in；
Step 5 is closed after opening suction pump 1 second, so that the bioclastic in drive array is taken out by catheter
Sucking pump detaches locating biotic environment.
The method of the present invention is easy to operate based on micro-electromechanical technology and special wire-grid structure, suitable in smaller space
Bioclastic acquisition.
Claims (1)
1. a kind of bioclastic acquisition method, bioclastic capture device include outer sleeve (1), linkage section (2), driver (3),
Four elastic rings (4), wire-grid structure (5), catheter (6), suction pump, X-ray production apparatus, Thin cable and voltage source, xyz are three-dimensional sit
Mark system, outer sleeve (1) are coaxially adhesively fixed with linkage section (2) with epoxy resin, and driver (3) includes six sheets, six pieces
Shape all has starting point and end, and the starting point of six sheets of driver (3) is successively solid with the side of linkage section (2) in uniform way
It is fixed, and arrange and to form a drive array, the central axis of the drive array and outer sleeve (1) coaxially, driver (3)
The plane that the end of six sheets is formed is the import of drive array, and six sheets pass through Thin cable respectively and are all connected with voltage
Source when voltage source applies different voltages, enables to six sheets to occur different degrees of Bending Deformation, between adjacent sheet
With wire-grid structure (5), wire-grid structure (5) is made of zigzag siloxane structure arranged in parallel, four elastic rings (4) it is outer
The inside of six sheets of side and driver (3) is bonded by epoxy resin, so that four elastic rings (4) are coaxially installed on driving
The inside of device array, the spacing between adjacent resilient rings are 1 millimeter；Outer sleeve (1) is polyethylene pipe, the outer diameter of outer sleeve (1)
For 6 millimeters, internal diameter be 5 millimeters, length is 10 millimeters；Linkage section (2) is titanium alloy tube, and the outer diameter of linkage section (2) is 5.5 millis
Rice, internal diameter are 5 millimeters, length is 4 millimeters；Six sheets of driver (3) be length be 8 millimeters, width is 1.8 millimeters,
With a thickness of 200 microns of metallic composite；The diameter of Thin cable is 80 microns；Four elastic rings (4) are that outer diameter is 5 millis
Rice, internal diameter are made by 4.9 millimeters and of macromolecular material；Wire-grid structure (5) with a thickness of 3 microns, between adjacent saw-tooth shape
Away from being 20 microns, the coefficient of elasticity of wire-grid structure (5) in the z-direction is 2 ns/m,
It is characterized in that: a kind of the step of bioclastic acquisition method are as follows:
The end of step 1, outer sleeve (1) is connected to suction pump by catheter, drives so that suction pump is connected to by catheter
The interior space of device array；
Step 2 to contrast agent is added in biotic environment locating for bioclastic capture device, and is seen by X-ray production apparatus
It examines；
Step 3, voltage source applies unified positive voltage by six sheets of the Thin cable to driver (3), so that driver battle array
The import of column expands, and drives drive array mobile by catheter, so that more bioclastics enter drive array
It is interior；
Step 4, after the bioclastic in drive array gathers, voltage source is by Thin cable to six pieces of driver (3)
Shape applies unified negative voltage, so that the import of drive array is reduced, bioclastic is limited in the sky in drive array
Between in；
Step 5 is closed after opening suction pump 1 second, so that the bioclastic in drive array is sucked pump by catheter
Detach locating biotic environment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910559206.0A CN110236642A (en) | 2019-06-18 | 2019-06-18 | A kind of bioclastic acquisition method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910559206.0A CN110236642A (en) | 2019-06-18 | 2019-06-18 | A kind of bioclastic acquisition method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110236642A true CN110236642A (en) | 2019-09-17 |
Family
ID=67889557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910559206.0A Pending CN110236642A (en) | 2019-06-18 | 2019-06-18 | A kind of bioclastic acquisition method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110236642A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100091549A (en) * | 2009-02-10 | 2010-08-19 | 전남대학교산학협력단 | The interior of the body wastes collector for medical treatment that use reticulation to ionic polymer metal composite and manufacture method |
| CN102686180A (en) * | 2009-11-04 | 2012-09-19 | 艾姆西森有限公司 | Lumenal remodelling device and methods |
| US20140074144A1 (en) * | 2012-09-11 | 2014-03-13 | Tyco Healthcare Group Lp | Retrieval catheter with expandable tip |
| US20140163603A1 (en) * | 2012-12-11 | 2014-06-12 | Alan Zajarias | Methods and apparatus for capturing embolic debris during endovascular procedures |
| CN104473681A (en) * | 2014-12-14 | 2015-04-01 | 李峰 | Foreign body net clamp for surgical operation |
| CN105828730A (en) * | 2013-12-24 | 2016-08-03 | 波士顿科学医学有限公司 | Medical retrieval devices and methods |
| WO2018136724A2 (en) * | 2017-01-20 | 2018-07-26 | W. L. Gore & Associates, Inc. | Embolic filter system |
| CN108420487A (en) * | 2018-04-10 | 2018-08-21 | 郑州大学第附属医院 | A kind of hook retracting device of visual controllable intracanal scaffold |
| CN109199631A (en) * | 2018-09-26 | 2019-01-15 | 李雷 | Inferior caval vein embolism filter |
-
2019
- 2019-06-18 CN CN201910559206.0A patent/CN110236642A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100091549A (en) * | 2009-02-10 | 2010-08-19 | 전남대학교산학협력단 | The interior of the body wastes collector for medical treatment that use reticulation to ionic polymer metal composite and manufacture method |
| CN102686180A (en) * | 2009-11-04 | 2012-09-19 | 艾姆西森有限公司 | Lumenal remodelling device and methods |
| US20140074144A1 (en) * | 2012-09-11 | 2014-03-13 | Tyco Healthcare Group Lp | Retrieval catheter with expandable tip |
| US20140163603A1 (en) * | 2012-12-11 | 2014-06-12 | Alan Zajarias | Methods and apparatus for capturing embolic debris during endovascular procedures |
| CN105828730A (en) * | 2013-12-24 | 2016-08-03 | 波士顿科学医学有限公司 | Medical retrieval devices and methods |
| CN104473681A (en) * | 2014-12-14 | 2015-04-01 | 李峰 | Foreign body net clamp for surgical operation |
| WO2018136724A2 (en) * | 2017-01-20 | 2018-07-26 | W. L. Gore & Associates, Inc. | Embolic filter system |
| CN108420487A (en) * | 2018-04-10 | 2018-08-21 | 郑州大学第附属医院 | A kind of hook retracting device of visual controllable intracanal scaffold |
| CN109199631A (en) * | 2018-09-26 | 2019-01-15 | 李雷 | Inferior caval vein embolism filter |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wang et al. | Robust biomimetic hierarchical diamond architecture with a self-cleaning, antibacterial, and antibiofouling surface | |
| CN103344464B (en) | Micro-fluidic agglutinin chip for glycosyl separation, and preparation method thereof | |
| US10391485B2 (en) | Microfluidic electrocage device and cell medium for trapping and rotating cells for live-cell computed tomography (CT) | |
| CN104485279A (en) | Transparent electrode based on metal nanometer grid and preparing method of transparent electrode | |
| CN100454080C (en) | Piezoelectric thick diaphragm driving micro deformable mirror and producing method thereof | |
| CN103105423B (en) | Interdigital electrode with nano-dot array, and preparation method and application thereof | |
| CN103337449B (en) | Method prepared by the transplanting of silicon nanowire array and simple Devices thereof | |
| CN1648662A (en) | Low temperature binding method for glass microflow control chip | |
| CN108147400B (en) | Transfer method and device of graphene film | |
| CN101148243A (en) | Method for making three-dimension electric casting micro structure | |
| CN103885300A (en) | Hydrophobic surface photoetching process | |
| CN107063812A (en) | A kind of low flake rate of liquid-based culture hydrophily adheres to the preparation method of slide | |
| CN101932146A (en) | Three-dimensional microheater with arc groove heating membrane area and manufacturing method thereof | |
| CN110236642A (en) | A kind of bioclastic acquisition method | |
| CN102519762A (en) | Method for preparing low-stress micro-tensile test sample with mesh support frame | |
| CN110215311A (en) | A kind of bioclastic capture device | |
| JP6409988B2 (en) | Cell capture filter, cell capture device, cell capture method, cell observation method, and cell culture method | |
| CN107998424A (en) | A kind of teaching experiment biochip cleaning sterilizing device | |
| CN110338939A (en) | The method for processing and assembling of driver and wire-grid structure in bioclastic capture device | |
| CN105025423B (en) | A kind of electret capacitor type sonac and preparation method thereof | |
| CN210673505U (en) | Biological debris catching device | |
| CN201075079Y (en) | Device for simulating biological medical material external dynamic erosion | |
| CN209005651U (en) | A kind of micro drop quick agitator based on ultrasound | |
| CN107400876B (en) | A method of nano-diamond membrane is graphically made using copper film | |
| CN1472556A (en) | Micromechanical optical switch made of metal material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |