CN110236490A - A kind of noninvasive function of vascular endothelium diagnostic equipment and its implementation - Google Patents
A kind of noninvasive function of vascular endothelium diagnostic equipment and its implementation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
- A61B5/726—Details of waveform analysis characterised by using transforms using Wavelet transforms
Abstract
The invention discloses a kind of noninvasive function of vascular endothelium diagnostic equipment and its implementation, diagnostic equipment includes induction temperature measurement module, bio-signal acquisition module, display module and microprocessor；The bio-signal acquisition module includes blood pressure detecting unit and blood oxygen detection unit；Method includes the blood pressure signal obtained according to blood pressure detecting unit and the blood oxygen signal that blood oxygen detection unit obtains, and determines that physiological characteristic value of the user in the blood vessels during skin Function detection meets health requirements；Induction stimulation is carried out to tiny blood vessels tip according to determining induction stimulation mode；Temperature acquisition is carried out to the post-stimulatory tiny blood vessels tip of induction；Blood vessel endothelium testing result is generated according to collected temperature signal；Real-time exhibition is carried out to blood oxygen signal, blood pressure signal, temperature signal and blood vessel endothelium testing result by display module.Present invention reduces cost and accuracy rate is improved, can be widely applied to Medical Instruments technical field.
Description
Technical field
The present invention relates to Medical Instruments technical field, especially a kind of noninvasive function of vascular endothelium diagnostic equipment and its realization side
Method.
Background technique
Endodermis is the monolayer for being covered in vascular inner surface, the permeability barrier or function more than one for being not only blood vessel
The paracrine of energy and endocrine organ, there is a variety of close to contact with many diseases for endothelial dysfunction, including diabetes,
Hypertension, apoplexy etc., and mostly occur in cardiovascular event early stage, can treatment stage, normal function of vascular endothelium be maintain
The primary condition of cardiovascular system stable state.Detection blood vessel endothelium dysfunction is in time to carry out early intervention and treatment to reverse
Vascular lesion, for safeguarding that cardiovascular health, the disease incidence for reducing cardiovascular disease and medical treatment cost are very crucial.Noninvasive endothelium
Function detection equipment relative to intrusive detection method, have it is easy to detect, make patient from or reduce wound, have preferable
Potential applicability in clinical practice.
It has gradually been obtained currently based on the function of vascular endothelium detection method of beam arm ischemic induced reaction hyperemia theory
The approval of industry, and gradually it is applied to the multiple fields such as cardiovascular disease, diabetes, nephrosis, andrological diseases.Present clinical application
Noninvasive function of vascular endothelium detection device mainly pass through to pressurize to arteria brachialis and block, the blood vessel of the congested front and back of observing response
Internal diameter variation, the endothelial function diagnostic instrments based on the theory occupy leading market status.
The foreign countries based on ultrasound and outer hoop tension technology development of clinical application at present both at home and abroad introduce noninvasive intravascular
Skin function detection equipment is all based on the induced reaction hyperemia of beam arm ischemic, to detect the vessel diameter variation before and after hyperemia or refer to
Sharp pulse wave amplitude variations；Using the noninvasive function of vascular endothelium diagnostic instrments of finger tip heat monitoring (DTM) technology development, measurement is former
Reason is also based on the recovery situation of finger temperature after beam arm blocks arteria brachialis, observing response congested.In fact, above-mentioned technology is all
The beam arm of use will cause human body forearm and hand ischemic, anoxic, and overlong time is easy that human body is made to generate discomfort, and price
Valuableness, testing cost is high, and assessment result is affected by many factors, and accuracy is not high.
Summary of the invention
In view of this, the embodiment of the present invention provides a kind of noninvasive function of vascular endothelium diagnostic equipment at low cost and high accuracy
And its implementation.
In a first aspect, the embodiment of the invention provides a kind of noninvasive function of vascular endothelium diagnostic equipment, including induction thermometric mould
Block, bio-signal acquisition module, display module and microprocessor；The bio-signal acquisition module include blood pressure detecting unit and
Blood oxygen detection unit；
Wherein, blood pressure detecting unit, for obtaining the blood pressure signal of user in function of vascular endothelium detection process in real time；
Blood oxygen detection unit, for obtaining the blood oxygen signal of user in function of vascular endothelium detection process in real time；
Microprocessor controls signal for sending work starting to induction temperature measurement module, and according to blood pressure detecting unit
The blood oxygen signal and induce the temperature signal of temperature measurement module acquisition to trigger that the blood pressure signal of acquisition, blood oxygen detection unit obtain
It shows signal, and display signal is sent to display module；
Induce temperature measurement module, for integrated induction stimulation and temperature detecting function, by semiconductor chilling plate realize heating and
Cooling forms induction stimulation, and obtains the post-stimulatory temperature signal of induction；
Display module, for the display signal according to microprocessor, real-time display peripheral vessel temperature change and detection knot
Fruit.
Further, further includes:
Key module, for obtaining the input signal of user；
Power module, for providing working power for induction temperature measurement module；
Alarm module, for carrying out warning note according to the control signal of microprocessor；
Memory module, the blood oxygen letter for storing the blood pressure signal of blood pressure detecting unit acquisition, blood oxygen detection unit obtains
Number and induction temperature measurement module obtain temperature signal.
Second aspect, the embodiment of the invention also provides a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment, packets
Include following steps:
The blood oxygen signal that the blood pressure signal and blood oxygen detection unit obtained according to blood pressure detecting unit obtains, determines that user exists
Physiological characteristic value in function of vascular endothelium detection process meets health requirements；
Induction stimulation is carried out to tiny blood vessels tip according to determining induction stimulation mode, the induction stimulation mode includes
Thermostimulation and cold stimulation；
Temperature acquisition is carried out to the post-stimulatory tiny blood vessels tip of induction；
Blood vessel endothelium testing result is generated according to collected temperature signal；
Blood oxygen signal, blood pressure signal, temperature signal and blood vessel endothelium testing result are opened up in real time by display module
Show.
Further, the blood oxygen that the blood pressure signal obtained according to blood pressure detecting unit and blood oxygen detection unit obtain is believed
Number, determine the step for physiological characteristic value of the user in the blood vessels during skin Function detection meets health requirements, including following
Step:
User basic information is acquired, the essential information includes name, age, gender and medical history basic condition；
According to user basic information, safe pressure value and safe blood oxygen levels are determined；
Blood pressure signal is obtained by blood pressure detecting unit, and blood oxygen signal is obtained by blood oxygen detection unit；
Based on safe pressure value and safe blood oxygen levels, blood pressure signal and blood oxygen signal are monitored, determine user in blood
Physiological characteristic value during endothelial tube Function detection meets health requirements.
Further, the step for described pair of post-stimulatory tiny blood vessels tip of induction carries out temperature acquisition, including following step
It is rapid:
Acquisition induces the temperature signal of post-stimulatory tiny blood vessels tip；
Filtering processing is amplified to temperature signal is collected；
Denoising is carried out to the temperature signal after amplification filtering processing；
Feature extraction is carried out to the temperature signal after denoising.
Further, the step for temperature signal to after denoising carries out feature extraction, comprising the following steps:
Extract the room temperature value of tiny blood vessels tip；
The constant high temperature value of tiny blood vessels tip after extracting thermostimulation induction；
Obtain the stimulation removal time and room temperature value recovery time of thermostimulation induction.
Further, the step for temperature signal to after denoising carries out feature extraction, further comprising the steps of:
The permanent low-temperature values of tiny blood vessels tip after extracting cold stimulation induction；
It obtains the increase stimulation time point of cold stimulation induction and reaches the time point of permanent low temperature；
Obtain the cold stimulation removal time and room temperature value recovery time pierced and hit induction.
Further, described the step for blood vessel endothelium testing result is generated according to collected temperature signal, including it is following
Step:
Temperature variation curve is generated according to collected temperature signal；
Wavelet analysis is carried out to collected temperature signal, obtains temperature signal time-frequency figure；
According to temperature variation curve and temperature signal time-frequency figure, blood vessel endothelium testing result is generated.
Further, described the step for wavelet analysis is carried out to collected temperature signal, obtains temperature signal time-frequency figure,
The following steps are included:
By wavelet analysis method, endothelium is extracted from collected temperature signal and adjusts wave；
Wave is adjusted according to endothelium, calculates endothelial function area.
Further, described according to temperature variation curve and temperature signal time-frequency figure, generate blood vessel endothelium testing result this
Step, comprising the following steps:
Thermostimulation is induced, temperature variation curve is compared with the first reference curve, judges that tester's temperature is returned
Whether the speed for being grouped into room temperature value is faster than reference curve speed, if so, the endothelial function of discriminating test person is good；Conversely, then
The endothelial function of discriminating test person is not good enough；
Cold stimulation is induced, temperature variation curve is compared with the second reference curve, judges tester's temperature
Reduce whether speed is slower than reference curve speed and tester's temperature revert to the speed of room temperature value and whether is faster than reference curve speed
Degree, if so, the endothelial function of discriminating test person is good；Conversely, then the endothelial function of discriminating test person is not good enough；
The endothelial function area obtained according to wavelet analysis, judges whether endothelial function area is greater than reference value, if so,
The endothelial function of discriminating test person is good；Conversely, then the endothelial function of discriminating test person is not good enough.
One or more technical solutions in the embodiments of the present invention have the advantages that the embodiment of the present invention passes through
It induces temperature measurement module by the way of thermostimulation or cold stimulation, induction stimulation is carried out to tiny blood vessels tip, compared to existing
The arm-type detection method of beam, the present invention utilizes induced reaction hyperemia principle, passes through the temperature change of the small peripheral vessel of detection
Signal, generates blood vessel endothelium testing result, and at low cost and accuracy rate is high；Meanwhile the present invention passes through blood pressure detecting unit and blood oxygen
Detection unit determines that physiological characteristic value of the user in the blood vessels during skin Function detection meets health requirements, improves safety
Property.
Detailed description of the invention
Fig. 1 is a kind of overall structure block diagram of noninvasive function of vascular endothelium diagnostic equipment of the present invention；
Fig. 2 is the step flow chart of the embodiment of the present invention；
Fig. 3 is the structural schematic diagram of the diagnostic equipment host of the embodiment of the present invention；
Fig. 4 is the structural schematic diagram of the induction temperature measurement module of the embodiment of the present invention；
Fig. 5 is the rear cover structure schematic diagram of the induction temperature measurement module of the embodiment of the present invention；
Fig. 6 is the first circuit diagram of the embodiment of the present invention；
Fig. 7 is the second circuit schematic diagram of the embodiment of the present invention.
Specific embodiment
The present invention is further explained and is illustrated with specific embodiment with reference to the accompanying drawings of the specification.For of the invention real
The step number in example is applied, is arranged only for the purposes of illustrating explanation, any restriction is not done to the sequence between step, is implemented
The execution sequence of each step in example can be adaptively adjusted according to the understanding of those skilled in the art.
Referring to Fig.1, the embodiment of the invention provides a kind of noninvasive function of vascular endothelium diagnostic equipments, including induction thermometric mould
Block, bio-signal acquisition module, display module and microprocessor；The bio-signal acquisition module include blood pressure detecting unit and
Blood oxygen detection unit；
Wherein, blood pressure detecting unit, for obtaining the blood pressure signal of user in function of vascular endothelium detection process in real time；
Blood oxygen detection unit, for obtaining the blood oxygen signal of user in function of vascular endothelium detection process in real time；
Microprocessor controls signal for sending work starting to induction temperature measurement module, and according to blood pressure detecting unit
The blood oxygen signal and induce the temperature signal of temperature measurement module acquisition to trigger that the blood pressure signal of acquisition, blood oxygen detection unit obtain
It shows signal, and display signal is sent to display module；
Induce temperature measurement module, for integrated induction stimulation and temperature detecting function, by semiconductor chilling plate realize heating and
Cooling forms induction stimulation, and obtains the post-stimulatory temperature signal of induction；
Display module, for the display signal according to microprocessor, real-time display peripheral vessel temperature change and detection knot
Fruit.
Referring to Fig.1, it is further used as preferred embodiment, further includes:
Key module, for obtaining the input signal of user；
Power module, for providing working power for induction temperature measurement module；
Alarm module, for carrying out warning note according to the control signal of microprocessor；
Memory module, the blood oxygen letter for storing the blood pressure signal of blood pressure detecting unit acquisition, blood oxygen detection unit obtains
Number and induction temperature measurement module obtain temperature signal.
Referring to Fig. 2, the embodiment of the invention also provides a kind of implementation methods of noninvasive function of vascular endothelium diagnostic equipment, including
Following steps:
The blood oxygen signal that the blood pressure signal and blood oxygen detection unit obtained according to blood pressure detecting unit obtains, determines that user exists
Physiological characteristic value in function of vascular endothelium detection process meets health requirements；
Induction stimulation is carried out to tiny blood vessels tip according to determining induction stimulation mode, the induction stimulation mode includes
Thermostimulation and cold stimulation；
Temperature acquisition is carried out to the post-stimulatory tiny blood vessels tip of induction；
Blood vessel endothelium testing result is generated according to collected temperature signal；
Blood oxygen signal, blood pressure signal, temperature signal and blood vessel endothelium testing result are opened up in real time by display module
Show.
It is further used as preferred embodiment, the blood pressure signal obtained according to blood pressure detecting unit and blood oxygen detect
The blood oxygen signal that unit obtains, determine physiological characteristic value of the user in the blood vessels during skin Function detection meet health requirements this
One step, comprising the following steps:
User basic information is acquired, the essential information includes name, age, gender and medical history basic condition；
According to user basic information, safe pressure value and safe blood oxygen levels are determined；
Blood pressure signal is obtained by blood pressure detecting unit, and blood oxygen signal is obtained by blood oxygen detection unit；
Based on safe pressure value and safe blood oxygen levels, blood pressure signal and blood oxygen signal are monitored, determine user in blood
Physiological characteristic value during endothelial tube Function detection meets health requirements.
Be further used as preferred embodiment, the described pair of post-stimulatory tiny blood vessels tip of induction carry out temperature acquisition this
One step, comprising the following steps:
Acquisition induces the temperature signal of post-stimulatory tiny blood vessels tip；
Filtering processing is amplified to temperature signal is collected；
Denoising is carried out to the temperature signal after amplification filtering processing；
Feature extraction is carried out to the temperature signal after denoising.
It is further used as preferred embodiment, the temperature signal to after denoising carries out this step of feature extraction
Suddenly, comprising the following steps:
Extract the room temperature value of tiny blood vessels tip；
The constant high temperature value of tiny blood vessels tip after extracting thermostimulation induction；
Obtain the stimulation removal time and room temperature value recovery time of thermostimulation induction.
It is further used as preferred embodiment, the temperature signal to after denoising carries out this step of feature extraction
Suddenly, further comprising the steps of:
The permanent low-temperature values of tiny blood vessels tip after extracting cold stimulation induction；
It obtains the increase stimulation time point of cold stimulation induction and reaches the time point of permanent low temperature；
Obtain the cold stimulation removal time and room temperature value recovery time pierced and hit induction.
It is further used as preferred embodiment, it is described that blood vessel endothelium testing result is generated according to collected temperature signal
The step for, comprising the following steps:
Temperature variation curve is generated according to collected temperature signal；
Wavelet analysis is carried out to collected temperature signal, obtains temperature signal time-frequency figure；
According to temperature variation curve and temperature signal time-frequency figure, blood vessel endothelium testing result is generated.
It is further used as preferred embodiment, it is described that wavelet analysis is carried out to collected temperature signal, obtain temperature
The step for signal time-frequency figure, comprising the following steps:
By wavelet analysis method, endothelium is extracted from collected temperature signal and adjusts wave；
Wave is adjusted according to endothelium, calculates endothelial function area.
It is further used as preferred embodiment, it is described according to temperature variation curve and temperature signal time-frequency figure, generate blood
The step for endothelial tube testing result, comprising the following steps:
Thermostimulation is induced, temperature variation curve is compared with the first reference curve, judges that tester's temperature is returned
Whether the speed for being grouped into room temperature value is faster than reference curve speed, if so, the endothelial function of discriminating test person is good；Conversely, then
The endothelial function of discriminating test person is not good enough；
Cold stimulation is induced, temperature variation curve is compared with the second reference curve, judges tester's temperature
Reduce whether speed is slower than reference curve speed and tester's temperature revert to the speed of room temperature value and whether is faster than reference curve speed
Degree, if so, the endothelial function of discriminating test person is good；Conversely, then the endothelial function of discriminating test person is not good enough；
The endothelial function area obtained according to wavelet analysis, judges whether endothelial function area is greater than reference value, if so,
The endothelial function of discriminating test person is good；Conversely, then the endothelial function of discriminating test person is not good enough.
The concrete operating principle of noninvasive function of vascular endothelium diagnostic equipment of the invention is described below in detail:
As shown in figure 3, the meaning of specific appended drawing reference is as follows in the structure of the diagnostic equipment host of the present embodiment: 1 representative lures
It leads and thermometric interface；2 represent induction mode；3 represent external blood pressure measurement；4 represent temperature curve；5 represent external Oximetry；
6 represent built-in SD card；7 represent stimulation selection toggle switch；8 represent emergent stopping key；9 represent status indicator lamp；10 representatives are opened
It closes；11 represent power interface；12, which represent measurement result, shows；13 represent power supply indicator.
The key, display and alarm module of the present embodiment include 1 power switch button, 10,1 three gear toggle switches 7,1
The liquid crystal display of a emergent stopping test 8,1 monochromatic burners of key, 1 dual-colored LED lamp, 9, model LCD12864.In Fig. 2,
Power button 10 for realizing power supply switching on and shutting down (short-press booting, long-pressing 1s shutdown)；Stimulation selection key 7 is that third gear is stirred out
It closes, realizes left 1 grade of addition thermostimulation, left 2 grades of addition cold stimulations, do not stir expression and do not add stimulation；Monochromatic burner is opened for showing
Machine state (red), bi-colour light 9 are for showing thermostimulation state (green), cold stimulation state (red green alternately flashing) and abnormal report
Alert state (red flashing)；Liquid crystal display is used for real-time display temperature curve 4 and checkout and diagnosis result 12.
As shown in figure 3, the diagnostic equipment host of the present embodiment is additionally provided with 1 16G Jin Shidun SD card 6, for storing data；Blood
Pressure meter interface 3 and BOLD contrast interface 5, external-connected port acquisition blood pressure and blood oxygen are monitored the body abnormality that can prevent measured
(when the blood pressure diastolic pressure of detection is lower than 90% greater than 140mmHg or blood oxygen lower than 50mmHg or systolic pressure) emergent stopping test,
To ensure life security.
In the structural schematic diagram of induction temperature measurement module in Fig. 4 of the present embodiment, the meaning of each appended drawing reference is as follows: 1
Represent temperature sensor；2 representatives refer to lid；3 represent induction and thermometric interface；4 represent recessed finger belly；5 represent heat-preservation cotton；6 represent half
Conductor cooling piece.
Wherein, as shown in figure 4, the induction temperature measurement module of the present embodiment is made by 1 NTC paster thermistor (0805 10K)
Heating and cooling module are used as using PTC cooling piece 6 for detecting temperature and feeding back to microprocessor for temperature sensor 1.
Wherein temperature sensor 1 is placed in 6 top of induction temperature measurement module center cooling piece, and heat preservation is posted between temperature sensor and cooling piece
Cotton 5, to be thermally shielded and provide comfort；Induction stimulation issues control signal control by microprocessor.The present embodiment is by luring
It leads and is fixedly connected with thermometric interface 3 with diagnostic equipment host.
In addition, as shown in figure 4, in order to provide good heat insulation effect, and the uniform temperature point of guarantee to tested finger tip
Cloth and good detection effect, the present embodiment are provided with the recessed finger belly 4 and dismountable elasticity for the concave shape being bonded with finger shape
Glue refers to lid 2, is filled between concave finger belly 4 and cooling piece 6 (including around heat-preservation cotton) with good Heat Conduction Material.
As shown in figure 5, the rear cover in the present embodiment is provided with radiator window 7 in order to realize good refrigerating function.
In addition, as shown in Figure 6 and Figure 7, the specific working principle is as follows for the induction temperature measurement module of the present embodiment:
For the present embodiment after the switch power supply key for connecting equipment power supply, power lights are bright for red, microprocesser initialization, prompt
The defeated people's essential information of tester；Then temperature sensor temperature collection data, blood pressure, blood oxygenation information are controlled, and amplification filter in real time
Storage and display screen are shown in storage SD card after wave；Wherein microprocessor controls bi-colour light according to blood pressure signal and blood oxygen signal
The on-off of D1 and triode Q4, the i.e. on-off of warning circuit, the constantly alternately on-off alarm if the blood pressure blood oxygen of user is abnormal
Circuit, so that blinking red lamp is to prompt emergent stopping test, (the present embodiment is equipped with emergent stopping feeler switch and controls emergent stopping
Test)；After testing 6 minutes under normality, microprocessor issues selection induction mode to display screen, and after tester's selection, induction adds
Enter to be tested；Specifically, if it is thermostimulation, then metal-oxide-semiconductor Q1 is logical, and Q2 is disconnected, and Q3 is logical；If it is cold stimulation, then metal-oxide-semiconductor
Q1 is disconnected, and Q2 is logical and Q3 and Q4 alternately on-off simultaneously, induced after about 8 minutes it is automatic remove, longest waits observation in 10 minutes small
Blood vessel distal temperature recovery situation, while microprocessor control display screen carries out result displaying.
The course of work of noninvasive function of vascular endothelium diagnostic equipment of the invention is as follows:
Start to acquire data, including tester's essential information such as name, age, gender, medical history base after equipment starting first
This situation input, blood pressure, blood oxygen, tiny blood vessels tip detection temperature etc., monitors human body by preset safe blood pressure, blood oxygen
While whether blood pressure blood oxygen is abnormal, temperature data is acquired, collected coherent signal is then stored in storage mould
In block, function of vascular endothelium is diagnosed according to these signals so as to subsequent.
In use, user will refer to that lid is inserted in host and fixes first, connect noninvasive vascular function instrument host power supply, even
Blood pressure, blood oxygen, induction temperature measurement module are connect, left index finger is put into recessed finger belly and elastic gum refers to lid space, opens host power supply, it is monochromatic
Lamp is displayed in red, and inputs essential information according to prompt, whether blood pressure and blood oxygen alternative are inserted into access measurement, if access
Measurement result shows that room temperature detection 6mins or so host can prompt selection induction mode in display screen, with three gear toggle switch choosings
Heat or cold stimulation are selected, bi-colour light state change (hot is green, cold for red green alternately flashing), expression induction has been added, finger tip temperature
Degree variation can real-time display；The constant temperature for reaching setting stimulates automatic disconnection for a period of time, after about 8mins, and bi-colour light returns
OFF state, room temperature measurement finger temperature are changed to constant obtain and 10mins or so measurement are waited to terminate, entire measurement process trend
Curve can be shown in display screen, while entire diagnostic result shows that measurement terminates, as there is abnormal bi-colour light meeting in measurement process
Red flashing alarm can be stopped testing by emergent stopping feeler switch.
A kind of specific implementation step of the implementation method of noninvasive function of vascular endothelium diagnostic equipment of the present invention is described below in detail:
Noninvasive function of vascular endothelium diagnostic equipment includes diagnostic equipment host and external induction temperature measurement module, important physiological signal inspection
Survey components such as module (i.e. external blood oxygens, blood pressure detecting module).Noninvasive function of vascular endothelium diagnostic equipment circuit is lured by microprocessor
Lead temperature measurement module, power module, key and display, alarm module, memory module, the big portion of important bio-signal acquisition module etc. six
It is grouped as (as shown in Figure 1), wherein microprocessor circuit is as main control unit.
Power module: switching to 12V DC power supply for 220V alternating current by power supply adaptor, supplies for induction temperature measurement module refrigeration
Electricity realizes that cooling piece freezes to the temperature of setting (refrigeration is to 5 DEG C)；12V DC voltage is switched into 9V by voltage stabilizing chip L7809
To lead temperature measurement module heating power supply, realizes the temperature (being heated to 40 DEG C) for being heated to setting, 5V DC voltage is switched to by L7805
To microprocessor power supply.
Microprocessor: using STC12C5608AD single-chip microcontroller as microprocessor, temperature collection sensor temperature, with setting
Temperature be compared the on-off for issuing pulse-width signal control high-power MOS field-effect tube (Q1 and Q2 of Fig. 6) connecting or
Cooling piece is disconnected, whether stimulate, provide thermostimulation or cold stimulation if realizing, provide accurate temperature control when stimulation, guarantee to add
Heat is constant for set temperature (such as heats constant 40 DEG C or refrigeration to 5 DEG C), at the same also control light status, safety protective circuit and
Storage and display circuit.
It induces temperature measurement module: temperature sensor being used as by 1 NTC paster thermistor (0805 10K), detection temperature is anti-
Microprocessor of feeding is calculated and compared, using PTC cooling piece as heating and cooling module.Wherein temperature sensor, which is placed in, lures
It leads above the cooling piece of temperature measurement module center, heat-preservation cotton is pasted between cooling piece, with heat-insulated and offer comfort；Induction stimulation is by micro-
Processor issues control signal control；For good tested finger tip heat preservation and guarantee uniform Temperature Distribution and good detection,
Concave shape is bonded with finger shape provided with placement and dismountable elastic gum refers to lid, wherein (is protected between concave shape and cooling piece
Around warm cotton) it is filled with good Heat Conduction Material；In order to realize that good refrigerating function, this module rear cover are provided with radiator window.
Key and display, alarm module: by 1 power switch button, 1 three gear toggle switches, 1 emergent stopping test
Key, 1 monochromatic burner and 1 dual-colored LED lamp and a LCD12864 liquid crystal display composition.The switching on and shutting down of power button realization power supply
(short-press booting, long-pressing 1s shutdown)；Stimulation selection key is third gear toggle switch, realizes left 1 grade of addition thermostimulation, left 2 grades of additions
Cold stimulation does not stir expression and does not add stimulation；Monochromatic burner is for showing open state (red), bi-colour light for showing thermostimulation
State (green), cold stimulation state (red green alternately flashing) and abnormal alarm state (red flashing)；Liquid crystal display is for aobvious in real time
Temperature displaying function curve and checkout and diagnosis result.
Memory module: by 1 16G Jin Shidun SD card storing data.The temperature that microprocessor detects send real-time display same
When write-in SD card storage for recalled at the end of detect setting time carry out calculate analysis provide diagnostic result and display entirely examine
The data of the temperature curve of survey, collection can subsequent scientific research use.
Important bio-signal acquisition module: blood pressure and blood oxygen are the important physiological signals of human body, this module mainly includes blood pressure
Meter and BOLD contrast, for microprocessor by stimulating detection function of vascular endothelium simultaneously in induction, external-connected port acquires blood pressure and blood oxygen
The body abnormality that can prevent measured is monitored (when the blood pressure diastolic pressure of detection is lower than 50mmHg or systolic pressure is greater than
140mmHg or blood oxygen are tested lower than 90%) emergent stopping, to ensure life security.
In the present embodiment, start to acquire data after equipment starting first, including tester's essential information such as name, the age,
Gender, the input of medical history basic condition, blood pressure, blood oxygen, tiny blood vessels tip detection temperature etc., by with preset safe blood pressure,
While whether blood oxygen is compared to monitoring human blood-pressure blood oxygen extremely, filtering is amplified to temperature data, removal is interfered
It is extracted with noise, characteristic, the function of vascular endothelium evaluation index for being then based on setting diagnoses function of vascular endothelium.
Wherein, function of vascular endothelium evaluation diagnostic method is to be stimulated based on the capilary tip (finger tip or toe etc.) detected in induction
Under temperature variation curve and wavelet analysis obtain temperature signal time-frequency figure judgement.
(1) for thermostimulation checkout and diagnosis
The characteristic point of extraction includes: room temperature point T0, default constant high temperature Tmax, stimulation removal time t0, restore first room temperature
Point time t1Or default cutoff test time td；
The judgement schematics of diagnostic result are as follows: F1=(Tmax-T0)/(t1Or td-t0)；
(2) for cold stimulation checkout and diagnosis
The characteristic point of extraction includes: room temperature point T0, increase stimulation time point t0, preset perseverance low temperature Tmin, reach permanent low temperature
Time point t1, stimulation removal time t2, restore first room temperature point time t3Or default cutoff test time td, it is greater than room temperature point
Temperature TKn(n=0...n)
Judgement schematics: F2=(T0-Tmin)/(t1-t0)；
F3=(T0-Tmin)/(t3Or td-t2)；
(3) wavelet analysis temperature signal time-frequency endothelial function areal calculation:
It include that active mode has muscle-derived to adjust (regulating cycle 7-20s), nerve modulation (20- in blood flow regulation mode
50s), endothelium adjusts (50-105s) and passive mode heartbeat (regulating cycle 0.5-2s) and breathing (2-7s), these regulative modes
Certain interference will be generated to the diagnosis of Endothelial function.Pass through the difference week of these regulative modes in diagnostic method of the present invention
Phase feature extracts subsignal endothelium and adjusts wave, it is 50-105s that endothelium, which adjusts wave section R, by wavelet analysis temperature signal
Then the amplitude curve of time wave band seeks intervening areas S.
Specific implementation are as follows: according to detect capilary tip (finger tip or toe etc.) induction stimulation under temperature curve with
Reference curve is compared, and the fine or not difference of function of vascular endothelium is mainly reflected in the recovery situation after induction stimulation removes.
Wherein, after induction removes under thermostimulation, the good tester's temperature of function of vascular endothelium revert under normality warm
The speed of degree is faster than reference curve speed, i.e. tester's temperature that the faster endothelial function of speed is better, and function of vascular endothelium is not good enough
Recurrence speed is slow, i.e., and function more differential degree is slower, i.e. F1Bigger endothelial function is better；
Under cold stimulation, the good tester of function of vascular endothelium, temperature reduction is slower, and temperature recovery speed is got over after stimulation removes
Fastly and slightly larger than temperature under normality, normality is then returned, i.e., temperature reduction is slower, temperature recovery speed is faster, and has TKnValue
When, endothelial function is better, and temperature reduces fast under function is not good enough person's cold stimulation, and temperature recovery speed is slow after stimulation removes and will not surpass
Cross temperature under normality.That is F2Smaller, F3It is bigger and have TKnIt is better to be worth endothelial function；F2Bigger, F3It is smaller and without TKnIt is worth intravascular
Skin function is poorer.
Meanwhile the temperature signal time-frequency figure that the present embodiment combination wavelet analysis obtains, compare the endothelium regulator letter of extraction
Area S in number section R, the wave band are more obvious, i.e. S is bigger, and expression function is better.
Specifically, the use process of the diagnostic equipment of the present embodiment are as follows:
It will refer to that lid is inserted in host and fixes, connect noninvasive vascular function instrument host power supply, connection blood pressure, blood oxygen, induction thermometric
Left index finger is put into recessed finger belly and elastic gum refers to lid space, opens host power supply by module, and monochromatic burner is displayed in red, according to prompt
Essential information is inputted, whether blood pressure and blood oxygen alternative are inserted into access measurement, and measurement result is in display screen display if access
Show, room temperature detection 6mins or so host can prompt selection induction mode, double-colored with three gear toggle switch selection heat or cold stimulation
Lamp state change (heat is green, cold to flash for red green alternating), indicates that induction has been added, finger temperature variation meeting real-time display；
The constant temperature for reaching setting stimulates automatic disconnection for a period of time, after about 8mins, and bi-colour light returns OFF state, room temperature measurement
Finger temperature is changed to constant obtain and 10mins or so measurement is waited to terminate, and entire measurement process trend curve can be shown in display
Screen, while entire diagnostic result shows that measurement terminates, such as occurring abnormal bi-colour light in measurement process red can flash alarm, can
Stop testing by emergent stopping feeler switch.
In conclusion the present invention utilizes induced reaction hyperemia principle, induction cold heat is carried out using to small peripheral vessel
Stimulation, is able to detect that the temperature change of small peripheral vessel, reduces the interference of other adjusting activities and noise, more intuitive standard
True reflection function of vascular endothelium.The equipment of development has measurement accurate, and small in size, at low cost, stability is good, detects portable etc.
Advantage.Compared with blood vessels present endothelial function diagnostic techniques and clinical application product, the invention avoids currently used beam arm sides
Formula realizes that reactive hyperemia will cause human body forearm and hand ischemic, anoxic, and overlong time is easy that human body is made to generate discomfort, and
And valuable product, the problems such as testing cost is high.
It is to be illustrated to good implementation of the invention, but the present invention is not limited to the embodiment above, it is ripe
Various equivalent deformation or replacement can also be made on the premise of without prejudice to spirit of the invention by knowing those skilled in the art, this
Equivalent deformation or replacement are all included in the scope defined by the claims of the present application a bit.
Claims (10)
1. a kind of noninvasive function of vascular endothelium diagnostic equipment, it is characterised in that: including inducing temperature measurement module, bio-signal acquisition mould
Block, display module and microprocessor；The bio-signal acquisition module includes blood pressure detecting unit and blood oxygen detection unit；
Wherein, blood pressure detecting unit, for obtaining the blood pressure signal of user in function of vascular endothelium detection process in real time；
Blood oxygen detection unit, for obtaining the blood oxygen signal of user in function of vascular endothelium detection process in real time；
Microprocessor controls signal for sending work starting to induction temperature measurement module, and is obtained according to blood pressure detecting unit
Blood pressure signal, blood oxygen detection unit obtain blood oxygen signal and induction temperature measurement module obtain temperature signal come trigger display
Signal, and display signal is sent to display module；
Temperature measurement module is induced, for integrated induction stimulation and temperature detecting function, heating and cooling are realized by semiconductor chilling plate
Induction stimulation is formed, and obtains the post-stimulatory temperature signal of induction；
Display module, for the display signal according to microprocessor, real-time display peripheral vessel temperature change and testing result.
2. a kind of noninvasive function of vascular endothelium diagnostic equipment according to claim 1, it is characterised in that: further include:
Key module, for obtaining the input signal of user；
Power module, for providing working power for induction temperature measurement module；
Alarm module, for carrying out warning note according to the control signal of microprocessor；
Memory module, for store blood pressure detecting unit acquisition blood pressure signal, blood oxygen detection unit obtain blood oxygen signal with
And the temperature signal that induction temperature measurement module obtains.
3. a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment, it is characterised in that: the following steps are included:
The blood oxygen signal that the blood pressure signal and blood oxygen detection unit obtained according to blood pressure detecting unit obtains, determines user in blood vessel
Physiological characteristic value in endothelial function detection process meets health requirements；
Induction stimulation is carried out to tiny blood vessels tip according to determining induction stimulation mode, the induction stimulation mode includes Spurs
Sharp and cold stimulation；
Temperature acquisition is carried out to the post-stimulatory tiny blood vessels tip of induction；
Blood vessel endothelium testing result is generated according to collected temperature signal；
Real-time exhibition is carried out to blood oxygen signal, blood pressure signal, temperature signal and blood vessel endothelium testing result by display module.
4. a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment according to claim 3, it is characterised in that: described
The blood oxygen signal that the blood pressure signal and blood oxygen detection unit obtained according to blood pressure detecting unit obtains, determines user's skin in the blood vessels
The step for physiological characteristic value during Function detection meets health requirements, comprising the following steps:
User basic information is acquired, the essential information includes name, age, gender and medical history basic condition；
According to user basic information, safe pressure value and safe blood oxygen levels are determined；
Blood pressure signal is obtained by blood pressure detecting unit, and blood oxygen signal is obtained by blood oxygen detection unit；
Based on safe pressure value and safe blood oxygen levels, blood pressure signal and blood oxygen signal are monitored, determine user in the blood vessels
Physiological characteristic value during skin Function detection meets health requirements.
5. a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment according to claim 3, it is characterised in that: described
The step for inducing post-stimulatory tiny blood vessels tip to carry out temperature acquisition, comprising the following steps:
Acquisition induces the temperature signal of post-stimulatory tiny blood vessels tip；
Filtering processing is amplified to temperature signal is collected；
Denoising is carried out to the temperature signal after amplification filtering processing；
Feature extraction is carried out to the temperature signal after denoising.
6. a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment according to claim 5, it is characterised in that: described
The step for feature extraction is carried out to the temperature signal after denoising, comprising the following steps:
Extract the room temperature value of tiny blood vessels tip；
The constant high temperature value of tiny blood vessels tip after extracting thermostimulation induction；
Obtain the stimulation removal time and room temperature value recovery time of thermostimulation induction.
7. a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment according to claim 6, it is characterised in that: described
The step for feature extraction is carried out to the temperature signal after denoising, further comprising the steps of:
The permanent low-temperature values of tiny blood vessels tip after extracting cold stimulation induction；
It obtains the increase stimulation time point of cold stimulation induction and reaches the time point of permanent low temperature；
Obtain the cold stimulation removal time and room temperature value recovery time pierced and hit induction.
8. a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment according to claim 3, it is characterised in that: described
The step for generating blood vessel endothelium testing result according to collected temperature signal, comprising the following steps:
Temperature variation curve is generated according to collected temperature signal；
Wavelet analysis is carried out to collected temperature signal, obtains temperature signal time-frequency figure；
According to temperature variation curve and temperature signal time-frequency figure, blood vessel endothelium testing result is generated.
9. a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment according to claim 8, it is characterised in that: described
The step for is carried out by wavelet analysis, obtains temperature signal time-frequency figure for collected temperature signal, comprising the following steps:
By wavelet analysis method, endothelium is extracted from collected temperature signal and adjusts wave；
Wave is adjusted according to endothelium, calculates endothelial function area.
10. a kind of implementation method of noninvasive function of vascular endothelium diagnostic equipment according to claim 9, it is characterised in that: institute
The step for stating according to temperature variation curve and temperature signal time-frequency figure, generating blood vessel endothelium testing result, comprising the following steps:
Thermostimulation is induced, temperature variation curve is compared with the first reference curve, judges that tester's temperature is revert to
Whether the speed of room temperature value is faster than reference curve speed, if so, the endothelial function of discriminating test person is good；Conversely, then determining
The endothelial function of tester is not good enough；
Cold stimulation is induced, temperature variation curve is compared with the second reference curve, judges the reduction of tester's temperature
Whether speed is slower than reference curve speed and tester's temperature revert to the speed of room temperature value and whether is faster than reference curve speed, if
It is that then the endothelial function of discriminating test person is good；Conversely, then the endothelial function of discriminating test person is not good enough；
The endothelial function area obtained according to wavelet analysis, judges whether endothelial function area is greater than reference value, if so, determining
The endothelial function of tester is good；Conversely, then the endothelial function of discriminating test person is not good enough.
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