CN110236189A - A kind of composition and its preparation method and application for protecting eyesight - Google Patents

A kind of composition and its preparation method and application for protecting eyesight Download PDF

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Publication number
CN110236189A
CN110236189A CN201910551905.0A CN201910551905A CN110236189A CN 110236189 A CN110236189 A CN 110236189A CN 201910551905 A CN201910551905 A CN 201910551905A CN 110236189 A CN110236189 A CN 110236189A
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core material
microcapsules
wall material
composition
weight
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侯艳梅
吴桐
谢奎
陈瑶
詹智钧
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Hyproca Nutrition Co Ltd
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Hyproca Nutrition Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/03—Organic compounds
    • A23L29/045—Organic compounds containing nitrogen as heteroatom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/25—Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
    • A23L29/281—Proteins, e.g. gelatin or collagen
    • A23L29/284—Gelatin; Collagen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a kind of compositions and its preparation method and application for protecting eyesight, and the composition includes the component of following parts by weight: lutein 0.1~5, taurine 1~10, DHA 1~15, olive oil 1~15.Microcapsules based on the composition are made of core material and wall material, the parts by weight of the core material and wall material are as follows: core material 20~60, wall material 40~80；The core material is composition described in claim 1；The wall material is made of colloid and lactalbumin, and the mass percentage content of lactalbumin is 20~50% in the wall material.The composition of protection eyesight of the present invention has superior protection vision performance.Core material has not only acted as the synergy for resisting blue light damage in the microcapsules being fabricated to, and also improves the bioavailability of lutein.The wall materials of microcapsules selects colloid and lactalbumin to combine, and not only embedding rate is high (embedding rate up to 92%), and film forming is good when dry, and surface oil is low, and core material rate of release in enteron aisle digestion process is reasonable.

Description

A kind of composition and its preparation method and application for protecting eyesight
Technical field
The invention belongs to food technology fields, and in particular to a kind of composition and preparation method thereof for protecting eyesight and answer With.
Background technique
Nutrition Science and Technology Co., Ltd. discloses one kind in Chinese patent 201810508103.7 and has at the beginning of people from Jiangxi Help alleviate blue ray radiation injury composition and its application, comprising 2000 parts~8000 parts of docosahexaenoic acid (DHA) powder, 2 parts~200 parts of lutein substance, 1 part~100 parts of zeaxanthin ((3R, 3'R)-dihydroxy-beta carotene), rain life are red 100 parts~5000 parts of ball algae, 20~2000 parts of cyanidin extract and 300 parts~1400 parts of taurine.Help to alleviate blue light Radiation injury.
Hunan Aoyou Food and Nutrition Research Institute discloses a kind of containing lutein in Chinese patent 201010208565.0 Baby milk powder and preparation method thereof, comprising raw material milk powder 100g, 0.01~0.05g of nucleotide, lutein crystal 0.01~ 0.04g, 0.2~0.8g of docosahexaenoic acid, 0.3~1.0g of arachidonic acid.
Fujian Normal University disclosed in Chinese patent 201610339606.7 a kind of Olive oil microcapsule powder and its Preparation method includes 30~80 parts of core material；0.5~3 part of emulsifier；1~10 part of wall material；The core material is olive oil；Wall material is One or more of maltodextrin, cyclodextrin, pure glue, Arabic gum, casein sodium；Emulsifier is emulsifier selected from single sweet Rouge, single, double stearine, sucrose ester, sorbitan monostearate, sorbitol monooleate, polyoxyethylene sorbitol One of monoleate, egg yolk lecithin, soybean lecithin are several.Its technique is mixing after water phase is prepared respectively with oily phase, It is just emulsified by 10000-20000r/min high shear, then handles the high-pressure homogeneous of 2 20~40MPa.Olive obtained by the invention Oil microcapsule powder encapsulation ratio reaches 95% or more.
It is well known that lutein, which has, promotes dark adaptation ability, alleviate visual fatigue, resists blue light damage, alleviate glycosuria Sick retinopathy improves visual adaptation ability, improves Age related macular portion lesion, reduces incidence of cataract, promotes vision Discriminating function etc..The approach that lutein is metabolized in vivo are as follows: lutein is dissolved into mixed micelle after entering stomach, small intestine, is turned It moves on to intestinal epithelial cell to be absorbed, target organ is transported in the circulatory system.The bioavailability of lutein in vivo is eaten The influence of object matrix, lipid, food process processing method, in some cases, the content of food Lutein are not given birth to it Object utilization rate is positively correlated, if the other compositions in opposite food form certain micellas with lutein in small enteral and may press down The absorption of lutein processed.
Summary of the invention
The present invention is directed to overcome the deficiencies of the prior art and provide composition of a kind of protection eyesight and preparation method thereof and answer With.
In order to achieve the above object, technical solution provided by the invention are as follows:
It is described protection eyesight composition include following parts by weight component: lutein 0.1~5, taurine 1~10, DHA1~15, olive oil 1~15.
Microcapsules based on above-mentioned composition are made of core material and wall material, the parts by weight of the core material and wall material are as follows: core material 20~60, wall material 40~80；The core material is composition described in claim 1；The wall material is by colloid and lactalbumin group At the mass percentage content of lactalbumin is 20~50% in the wall material.
Preferably, the colloid in Arabic gum, gelatin, starch octenyl succinate anhydride or maltodextrin at least It is a kind of.
Preferably, the lactalbumin is selected from least one of milk albumin or sheep lactalbumin.
The above-mentioned preparation method for stating microcapsules includes the following steps:
(1) it prepares wall material: obtaining wall material after lactalbumin and colloid are mixed in above-mentioned ratio；
(2) water dissolution and is kept the temperature wall material: by wall material and distilled water 1:(3.5~6 in mass ratio) mix after, in 40~60 DEG C 30~90min is kept the temperature in water-bath；
(3) it prepares core material: obtaining core material after lutein, taurine, DHA, olive oil are mixed in above-mentioned ratio；
(4) core material is kept the temperature: by core material in 15~30min of heat preservation in 20~35 DEG C of water-baths；
(5) by after isothermal holding wall material and core material stir 5~8min after, with the revolving speed high shear of 900~2000r/min (just emulsification) 60~120s, it is then high-pressure homogeneous then spray-dried under the conditions of 25~45MPa of pressure, 50~65 DEG C of temperature After be filled with inert gas and nitrogen to get microcapsules finished product.
Preferably, step (5) spray drying is using high-pressure spray-drying, and control inlet air temperature is 140~190 DEG C, atomizing pressure be 5MPa~10MPa, temperature of outgoing air is 75~85 DEG C.
Composition and microcapsules of the present invention can be used for preparing the food of protection eyesight, especially goat milk product.It is excellent The weight of selection of land, the composition or microcapsules accounts for the 0.1~6% of food weight.It is highly preferred that the composition or microcapsules Weight account for the 0.3~6% of food weight.
The invention will be further described below:
The absorptivity and food matrix of lutein have much relations, dietary fiber and polyunsaturated fatty acid and certain classes The effect that carrotene can inhibit lutein to absorb, and monounsaturated fatty acids can promote lutein bioavailability.This hair It is bright that lutein, taurine, the merging of DHA group are dissolved in olive oil, then are fabricated to one kind by embedding techniques and may be added to that food Microcapsules in product.The main component of grease microcapsule wall material is protein and carbohydrate, and wherein protein has hydrophilic, close Oil base group can play emulsifier effect in grease microcapsule emulsification system stroke, reduce the interfacial tension of water phase and oily phase, Stable oil-in-water system is formed, the existing good emulsibility of the hydrophilic gel class in carbohydrate, compounding with protein makes With the compactness that grease microcapsule mill can be improved, enhances the mechanical strength of microcapsule membrane, prevent core material grease in storage process Infiltration and oxidation.And in microcapsules preparation process, emulsification is committed step, but if emulsification condition requirement is very high, although having Help improve embedding rate, but is unfavorable for industrialization production.Therefore suitable emulsification parameter is particularly important.
Compared with prior art, the invention has the benefit that
The composition of protection eyesight of the present invention has superior protection vision performance.Core material in the microcapsules being fabricated to The synergy for resisting blue light damage has been not only acted as, the bioavailability of lutein is also improved.The wall material of microcapsules is selected Colloid and lactalbumin combine, and not only embedding rate is high (embedding rate up to 92%), and film forming is good when dry, and surface oil is low, and Core material rate of release in enteron aisle digestion process is reasonable.
Detailed description of the invention
Fig. 1 is nitric oxide level figure in rat blood serum after blue light illumination；
Fig. 2 is rat blood serum glutathione s-transferase (GST) level view after blue light illumination；
Fig. 3 is rat blood serum catalase (CAT) level view after blue light illumination；
Fig. 4 is rat c reactive protein (CRP) level view after blue light illumination；
Fig. 5 is interleukin-1 beta (IL-1 β) level view after blue light illumination rat；
Fig. 6 is tumor necrosis factor α (TNF-α) level view after blue light illumination rat.
Specific embodiment
Embodiment 1
The microcapsules of protection eyesight: 55 parts of core material, 45 parts of wall material；
The preparation method is as follows:
Wall material ingredient: Arabic gum, starch octenyl succinate anhydride, sheep lactalbumin by weight 2,1,2 mix；
Water dissolves wall material: wall material is mixed with distilled water 1:3.5 in mass ratio；
Wall material heat preservation: wall material keeps the temperature 90min in 40 DEG C of water-baths after mixing with distilled water；
Core material ingredient: lutein, taurine, DHA, olive oil by weight 1,1,2,6 mixes；
Core material heat preservation: mixed core material keeps the temperature 30min in 20 DEG C of water-baths；
Stir and evenly mix: wall material and core material after heat preservation stir at low speed 8min；
High shear (just emulsification): with the revolving speed high shear 120s of 900r/min；
It is high-pressure homogeneous: 65 DEG C of homogenizing temperature, pressure 35MPa；
Spray drying: using high-pressure spray-drying, 180~190 DEG C of inlet air temperature, control atomizing pressure 8MPa~10MPa, 75~85 DEG C of temperature of outgoing air；Up to the microcapsules of protection eyesight.
Embodiment 2
The microcapsules of protection eyesight: 30 parts of core material, 70 parts of wall material；
The preparation method is as follows:
Wall material ingredient: maltodextrin, milk albumin, sheep lactalbumin by weight 6,2,1 mix；
Water dissolves wall material: wall material is mixed with distilled water 1:4 in mass ratio；
Wall material heat preservation: wall material keeps the temperature 30min in 60 DEG C of water-baths after mixing with distilled water；
Core material ingredient: lutein, taurine, DHA, olive oil by weight 2,1,1,6 mixes；
Core material heat preservation: mixed core material keeps the temperature 15min in 35 DEG C of water-baths；
Stir and evenly mix: wall material and core material after heat preservation stir at low speed 5min；
High shear (just emulsification): with the revolving speed high shear 60s of 2000r/min；
It is high-pressure homogeneous: 50 DEG C of homogenizing temperature, pressure 45MPa；
Spray drying: using high-pressure spray-drying, 140~160 DEG C of inlet air temperature, control atomizing pressure 5MPa~7MPa, 75~85 DEG C of temperature of outgoing air；Up to the microcapsules of protection eyesight.
Embodiment 3
The microcapsules of protection eyesight: 20 parts of core material, 80 parts of wall material；
The preparation method is as follows:
Wall material ingredient: starch octenyl succinate anhydride, gelatin, milk albumin, sheep lactalbumin by weight 2,3, 2.5,1.5 mixing；
Water dissolves wall material: wall material is mixed with distilled water 1:6 in mass ratio；
Wall material heat preservation: wall material keeps the temperature 80min in 45 DEG C of water-baths after mixing with distilled water；
Core material ingredient: lutein, taurine, DHA, olive oil by weight 0.5,1,3,5.5 mixes；
Core material heat preservation: mixed core material keeps the temperature 20min in 25 DEG C of water-baths；
It stirs and evenly mixs: after wall material and core material after heat preservation stir at low speed 6min；
High shear (just emulsification): with the revolving speed high shear 100s of 1200r/min；
It is high-pressure homogeneous: 55 DEG C of homogenizing temperature, pressure 25MPa；
Spray drying: using high-pressure spray-drying, 160~170 DEG C of inlet air temperature, control atomizing pressure 6MPa~8MPa, 75~85 DEG C of temperature of outgoing air；Up to the microcapsules of protection eyesight.
Embodiment 4
The microcapsules of protection eyesight: 60 parts of core material, 40 parts of wall material；
The preparation method is as follows:
Wall material ingredient: Arabic gum and sheep lactalbumin by weight 3.5,1 mix；
Water dissolves wall material: wall material is mixed with distilled water 1:5 in mass ratio；
Wall material heat preservation: wall material keeps the temperature 30~90min after mixing with distilled water in 40~60 DEG C of water-baths；
Core material ingredient: lutein, taurine, DHA, olive oil by weight 2,2,3,3 mixes；
Core material heat preservation: mixed core material keeps the temperature 25min in 30 DEG C of water-baths.
Stir and evenly mix: wall material and core material after heat preservation stir at low speed 7min
High shear (just emulsification): with the revolving speed high shear 100s of 1000r/min.
It is high-pressure homogeneous: 58 DEG C of homogenizing temperature, pressure 30MPa
Spray drying: using high-pressure spray-drying, 140~190 DEG C of inlet air temperature, control atomizing pressure 5MPa~10MPa, 75~85 DEG C of temperature of outgoing air；Up to the microcapsules of protection eyesight.
Comparative example 1
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that wall material without sheep whey Albumen, and 0.5 part of single, double stearine is added as emulsifier, remaining formula and technique are constant.
Comparative example 2
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that high shear (just emulsification) Condition is 15000r/min, 60s；Processing condition is 15~50min of first time homogenizing time, and homogenization pressure is 20~40Mpa, the The second homogenate time is 15~50min, and homogenization pressure is 20~50Mpa.
Comparative example 3
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that core material is free of olive oil, Remaining formula and technique are constant.
Comparative example 4
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that core material is free of DHA, Remaining formula and technique are constant.
Comparative example 5
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that core material is free of taurine, Remaining formula and technique are constant.
Comparative example 6
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that core material without taurine And DHA, remaining formula and technique are constant.
Comparative example 7
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that the lutein in core material Change zeaxanthin into, remaining formula and technique are constant.
Comparative example 8
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that the lutein in core material Change lutein ester into, remaining formula and technique are constant.
Comparative example 9
This comparative example provides a kind of microcapsules for protecting eyesight, and the difference with embodiment 1 is only that also containing in core material Zeaxanthin and lutein ester, lutein, zeaxanthin, lutein ester, taurine, DHA, olive oil by weight 0.33, 0.33,0.33,1,2,6 mixing, remaining formula and technique are constant.
The microcapsules grease embedding rate, lutein embedding rate, taurine for investigating Examples 1 to 4 and comparative example 1~2 embed The oxidation stability (table 1) of rate and microcapsules
1 microcapsules grease embedding rate (%) of table=[1- (total oil in surface oil/product)] × 100
Comparative example 1 Comparative example 2 Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4
Surface oil % 3.6 2.87 1.82 1.03 0.81 1.48
Total oil % 43.87 43.8 43.82 20.67 16.95 35.55
Grease embedding rate % 91.79 93.45 95.85 95.02 95.22 95.84
2 lutein embedding rate % of table: microcapsules Lutein actual measured value/theoretical value * 100
Comparative example 1 Comparative example 2 Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4
Lutein embedding rate % 83.82 87.73 94.18 93.67 90.00 90.58
3 taurine embedding rate % of table: taurine actual measured value/theoretical value * 100 in microcapsules
Comparative example 1 Comparative example 2 Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4
Taurine embedding rate % 83.09 89.91 92.00 92.67 90.50 94.42
By above three table, it is found that Examples 1 to 4 is with comparative example 2, the difference on embedding rate is little, but is superior to comparative example 1, Illustrate that wall material selection colloid and protein combination have preferable embedding rate, for comparative example 2 compared with Examples 1 to 4, embedding rate is poor It is different not significant, illustrate emulsification condition of the invention also and can have good embedding effect.
The microcapsules application of the protection eyesight of embodiment 5
1 method
Investigate the protective effect of embodiment 1 and the damage of 3~6 pairs of rat retina blue lights of comparative example
SD rat 36, male, 8 week old are unified to raise, and animal every 4 are a cage, animal indoor illumination intensity 150lx, 12 hours light and shade circulations, are fed with using normal diet, freely obtain drinking-water.
Using random digits table by 56 SD rats, it is randomly divided into 9 groups: Normal group (without any processing), mould Type control group (using blue light modeling), contrast groups 3 (comparative example 3), contrast groups 4 (comparative example 4), contrast groups 5 (comparative example 5), comparison 6 (comparative examples 6) of group, contrast groups 7 (comparative example 7), contrast groups 8 (comparative example 8), contrast groups 9 (comparative example 9), experimental group 1 (are implemented Example 1), stomach-filling is soluble in water by respective substance respectively, raises 30 days by the stomach-filling amount of 1g/ pcs/day of stomach-filling.It is put into after raising The dark adaptation that 24 hours are carried out in darkroom, place into blue light damage instrument in carry out 1.5h light exposure, after rat is sent back to secretly It is raised in room, measures its ERG after anaesthetizing after 72h, then directly put to death, extract eyeball and remove retina.Light injury parameter: blue Optical wavelength 452nm, 1400~1500lx of intensity.
2 measurement indexes
2.1 electroretinogram
Electroretinogram (ERG) the reaction retinal function under the conditions of dark adaptation is measured, delay time, A wave and B vibration are measured Width.
2.2 serum and retina biochemical indicator
2.2.1 oxidative stress measures
It is horizontal that ELISA method measures serum levels of nitric oxide (NO).
2.2.2 Antioxidant Indexes are horizontal
It is horizontal that ELISA method measures serum GST, CAT.
2.2.3 inflammatory reaction index of correlation
It is horizontal that ELISA method measures serum CA125, IL-1 β, TNF-α.
3, result
The variation (being shown in Table 4) of rat retina electrograph after 3.1 blue light illuminations
Variation of 4 blue light of table according to rear rat retina electrograph
Group Rod-a Rod-b Max-a Max-b
Normal group -11.4±14.71 78.90±19.94 -84.45±5.30 245.65±18.60
Model control group -3.05±2.82 9.62±0.68 -3.18±0.30 49.04±1.62
Contrast groups 3 -3.80±061 8.07±3.43 -2.37±11.59 36.20±21.28
Contrast groups 4 -5.43±2.72 19.73±6.21 -13.13±7.69 57.13±21.29
Contrast groups 5 -5.06±1.78 22.60±7.32 -21.37±8.46 81.20±37.90
Contrast groups 6 -4.38±1.73 23.00±11.76 -24.45±9.20 83.15±34.75
Contrast groups 7 -2.17±2.93 15.47±3.74 -19.20±6.55 61.20±23.40
Contrast groups 8 -2.05±3.54 21.05±14.64 -22.82±8.98 80.65±32.44
Contrast groups 9 -4.80±0.00 16.35±7.57 -16.50±8.74 53.00±38.75
Experimental group 1 -6.53±2.78 54.10±36.80 -47.80±34.59 170.07±128.00
Table 4 the result shows that, compared with Normal group, model control group, contrast groups and experimental group Rod react a wave, b wave Wave amplitude significantly reduces.Max reacts a wave, b wave wave amplitude significantly reduces.Experimental group Rod reacts a wave, b wave, and Max reacts a wave, b Wave amplitude is significantly raised compared with model control group and contrast groups, illustrates that formula plays synergy.
The variation of rat blood serum oxidative stress after 3.2 blue light illuminations
Fig. 1 shows: model control group serum levels of nitric oxide (NO) level significantly increases compared with Normal group, and each group It is found after intervening, compared with model control group, the level of each group serum levels of nitric oxide is all had dropped, and wherein experimental group 1 is significant Decline.
The variation of rat blood serum antioxidase after 3.3 blue light illuminations
Fig. 2 and Fig. 3 be as the result is shown: after rat receives blue light illumination, model control group Serum glutathione S transferase (GST), the content of catalase (CAT) reduces.After intervening, the study find that, compared with model control group, Ge Gegan Pre- group serum GST and CAT increased compared with model control group, and experimental group 1 obviously increases.Illustrate micro- glue of the invention The antioxidation of capsule.
The variation of rat blood serum inflammatory factor after 3.4 blue light illuminations
Fig. 4, Fig. 5 and Fig. 6 the result shows that: after rat receives blue light illumination, compared with Normal group, model control group blood In clear inflammatory levels improve, and c reactive protein (CRP), interleukin-1 beta (IL-1 β), tumor necrosis factor α (TNF-α) contain Amount significantly increases.After intervening, c reactive protein (CRP), interleukin-1 beta (IL-1 β), tumor necrosis factor α in serum (TNF-α) has decline in each group, but compared with the control group, and experimental group effect is more significant, it is shown that the micro- glue of the lutein Capsule resists the effect of blue light damage.

Claims (10)

1. a kind of composition for protecting eyesight, which is characterized in that the composition includes the component of following parts by weight: lutein 0.1~5, taurine 1~10, DHA1~15, olive oil 1~15.
2. a kind of microcapsules based on composition described in claim 1, which is characterized in that the microcapsules are by core material and wall material group At the parts by weight of the core material and wall material are as follows: core material 20~60, wall material 40~80；The core material is described in claim 1 group Close object；The wall material is made of colloid and lactalbumin, in the wall material mass percentage content of lactalbumin be 20~ 50%.
3. microcapsules as claimed in claim 2, which is characterized in that the colloid is selected from Arabic gum, gelatin, octenyl succinic At least one of acid-starch ester or maltodextrin.
4. microcapsules as claimed in claim 3, which is characterized in that the lactalbumin is selected from milk albumin or sheep whey At least one of albumen.
5. the preparation method of microcapsules as described in any one of claim 2 to 4, which is characterized in that the method includes walking as follows It is rapid:
(1) it prepares wall material: obtaining wall material after lactalbumin and colloid ratio as described in claim 2 are mixed；
(2) water dissolution and is kept the temperature wall material: by wall material and distilled water 1:(3.5~6 in mass ratio) mix after, in 40~60 DEG C of water-baths 30~90min of middle heat preservation；
(3) it prepares core material: obtaining core material after lutein, taurine, DHA, olive oil ratio according to claim 1 are mixed；
(4) core material is kept the temperature: by core material in 15~30min of heat preservation in 20~35 DEG C of water-baths；
(5) by after isothermal holding wall material and core material stir 5~8min after, with the revolving speed high shear 60 of 900~2000r/min~ 120s, it is then high-pressure homogeneous under the conditions of 25~45MPa of pressure, 50~65 DEG C of temperature, then it is spray-dried after be filled with indifferent gas Body and nitrogen are to get microcapsules finished product.
6. method as claimed in claim 5, which is characterized in that step (5) spray drying is to use high-pressure spray-drying, Control inlet air temperature is 140~190 DEG C, atomizing pressure is 5MPa~10MPa, temperature of outgoing air is 75~85 DEG C.
7. the application of composition as described in claim 1 or microcapsules described in requiring 3 in the food of preparation protection eyesight.
8. application as claimed in claim 2, which is characterized in that the food is goat milk product.
9. application as claimed in claim 8, which is characterized in that the weight of the composition or microcapsules accounts for food weight 0.1~6%.
10. application as claimed in claim 9, which is characterized in that the weight of the composition or microcapsules accounts for food weight 0.3~6%.
CN201910551905.0A 2019-06-25 2019-06-25 A kind of composition and its preparation method and application for protecting eyesight Pending CN110236189A (en)

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