CN110235901A - A kind of thimerosal and its preparation facilities for prevention and control African swine fever - Google Patents
A kind of thimerosal and its preparation facilities for prevention and control African swine fever Download PDFInfo
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- CN110235901A CN110235901A CN201910621720.2A CN201910621720A CN110235901A CN 110235901 A CN110235901 A CN 110235901A CN 201910621720 A CN201910621720 A CN 201910621720A CN 110235901 A CN110235901 A CN 110235901A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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Abstract
This application discloses a kind of thimerosals for prevention and control African swine fever, and this application provides a kind of thimerosal for prevention and control African swine fever, thimerosal is obtained by water electrolysis；The matrix composition of thimerosal is water, contains O in water3, hydroxyl radical free radical, hydrogen and hydrogen ion.In the application, O is contained in the thimerosal as made from electrolysis water3, hydroxyl radical free radical, hydrogen and hydrogen ion, above-mentioned thimerosal can to live pig growth bad border (colony house, crib, excrement pond etc.) disinfection, live pig body (intestines, stomach, blood) is carried out disinfection, treats and nursed simultaneously, by way of inside and outside take into account, realize comprehensive prevention and control to African swine fever, the health for guaranteeing live pig, controls the propagation of disease.
Description
Technical field
The application belongs to thimerosal technical field more particularly to a kind of thimerosal and its preparation for prevention and control African swine fever
Device.
Background technique
African swine fever (African Swine fever, ASF) is by African swine fever virus (African Swine fever
Virus, ASFV) one kind is acute caused by infection domestic pig and various wild boars (red river hog, aper etc.), hemorrhagic, strong
Infectious disease.Its pathogenic process is short, and the most acute and acute infection death rate is up to 100%.Therefore to African swine fever be monitored with
Prevention seems most important.
The vaccine of African swine fever can effectively be prevented due to not yet developing at present, existing prevention and control measure mainly has following
Several points: one, strict control personnel, vehicle and susceptible animal enter farm；Two, enclosed grazing live pig as far as possible, takes isolation
Safeguard procedures avoid contacting with wild boar, blunt edge soft ticks；Three, forbid using swill or remaining meal rubbish feeding live pig.Above-mentioned measure
Although can achieve certain control effect, still there is infection to happen.
Therefore, it is urgently to be resolved as those skilled in the art to develop a kind of thimerosal that can effectively prevent African swine fever
The technical issues of.
Summary of the invention
In view of this, this application provides a kind of thimerosal and its preparation facilities for prevention and control African swine fever, Ke Yiyou
Imitate prevention and control African swine fever.
The application first aspect provides a kind of thimerosal for prevention and control African swine fever, and the thimerosal passes through water electrolysis
It obtains；
The matrix composition of the thimerosal is water, contains O in the water3, hydroxyl radical free radical, hydrogen and hydrogen ion.
Optionally,
The O3Concentration is 0.1-50ppm.
Optionally,
The O3Concentration is 0.4-50ppm.
Optionally,
The O3Concentration is 0.1-20ppm.
Optionally,
The concentration of the hydroxyl radical free radical are as follows: 1-50mg/L.
Optionally,
The concentration of the hydroxyl radical free radical is 1-30mg/L.
Optionally,
The concentration of the hydroxyl radical free radical is 1-20mg/L.
Optionally,
Ingredient in the thimerosal further include: NaCl；
Mass percent of the NaCl in the thimerosal is 0.01%~1%.
Optionally, the ingredient of the thimerosal further includes at least one of:
Serum antibody, cold and raising immunity peptide, canavalin and cytotripeptide.
The application second aspect provides a kind of disinfectant preparation apparatus, for thimerosal described in above-mentioned first aspect
Preparation, comprising: water tank and the electrolysis unit being set to inside water tank.
In conclusion this application provides a kind of thimerosal for prevention and control African swine fever, thimerosal is obtained by water electrolysis
It arrives；The matrix composition of thimerosal is water, contains O in water3, hydroxyl radical free radical, hydrogen and hydrogen ion.
In the application, O is contained in the thimerosal as made from electrolysis water3, hydroxyl radical free radical, hydrogen and hydrogen ion, wherein
O3For strong oxidizer, the disinfectant of broad-spectrum high efficacy, hydroxyl radical free radical is the bioactive molecule with extremely strong oxidation susceptibility, it can make carefully
The protein oxidation denaturation of bacterium, virus, while being reacted with various pollutants, it is oxidized to H2O、CO2With other innocuous substances,
" hydrogen-rich water " obtained after hydrogen and hydrogen ion dissolution has good therapeutic efficiency and health-care efficacy.Above-mentioned thimerosal can be right
The growth bad border (colony house, crib, excrement pond etc.) of live pig sterilizes, while carrying out disinfection, controlling to live pig body (intestines, stomach, blood)
It treats and nursing is realized comprehensive prevention and control to African swine fever, guaranteed the health of live pig, control disease by way of inside and outside take into account
Propagation.
Specific embodiment
The embodiment of the present application provides a kind of thimerosal and its preparation facilities for prevention and control African swine fever, can effectively prevent
Control African swine fever.
Below by the technical scheme in the embodiment of the application is clearly and completely described, it is clear that described implementation
Example is merely a part but not all of the embodiments of the present application.Based on the embodiment in the application, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model of the application protection
It encloses.
This application provides a kind of thimerosal for prevention and control African swine fever, thimerosal is obtained by water electrolysis；Thimerosal
Matrix composition be water, contain O in water3, hydroxyl radical free radical, hydrogen and hydrogen ion.
In view of the technical problem in background technique, applicant carries out analysis to existing prevention and control measure and finds, existing nursing
Pig feeding feed can be finally arrived before the feed of pig by manufacture, transport, into links such as pig farms, it may be said that every before pig feeding feed
One link is all likely to occur a possibility that feed is infected viral.Therefore, if can fundamentally set out, live pig may be connect
The pathogenic bacteria of the pathogenic bacteria and endobiosis that contact all are killed, then live pig does not have infected possibility.
Contain O in the application in the thimerosal as made from electrolysis water3, hydroxyl radical free radical, hydrogen and hydrogen ion, wherein O3
For strong oxidizer, the disinfectant of broad-spectrum high efficacy, hydroxyl radical free radical is the bioactive molecule with extremely strong oxidation susceptibility, it can make carefully
The protein oxidation denaturation of bacterium, virus, while being reacted with various pollutants, it is oxidized to H2O、CO2With other innocuous substances,
" hydrogen-rich water " obtained after hydrogen and hydrogen ion dissolution has preferable therapeutic effect to the respiratory system of live pig, nervous system, and
" hydrogen-rich water " is used as a kind of drinking water, the better effect of health care.Above-mentioned thimerosal can to live pig growth bad border (circle
House, crib, excrement pond etc.) disinfection, while live pig body (intestines, stomach, blood) is carried out disinfection, treats and being nursed, by inside and outside
The mode taken into account realizes comprehensive prevention and control to African swine fever, guarantees the health of live pig, control the propagation of disease.
It should be noted that thimerosal system should be used, Cai Nengbao when the loss phenomenon due to ozone molecule in water
Demonstrate,prove its control effect.
Specifically, the O in the present embodiment3Concentration is 0.1-50ppm.It is understood that when thimerosal is filled for live pig
When stomach, the O of excessive concentration3While pathogenic bacteria in stomach can be killed, kill the enzyme of gas digestion in live pig stomach, beneficial to micro- life
Object etc. causes live pig digestion power to decline, influences the normal growth of live pig, or even make live pig illness, at this time O3Concentration cannot mistake
It is high.Therefore when thimerosal is used for live pig bowel lavage stomach, O3Concentration is 0.4-50ppm；When thimerosal is used to be injected intravenously, O3It is dense
Degree is 0.1-20ppm.
Specifically, the concentration of the hydroxyl radical free radical in the present embodiment are as follows: 1-50mg/L.It is understood that thimerosal is used
When live pig stomach-filling, while the hydroxyl radical free radical of excessive concentration can kill pathogenic bacteria in stomach, kill gas digestion in live pig stomach
Enzyme, beneficial microbe of effect etc. cause live pig digestion power to decline, influence the normal growth of live pig, or even make live pig illness,
Hydroxy free radical concentration cannot be excessively high at this time.It is understood that when thimerosal is used for live pig bowel lavage stomach, hydroxyl radical free radical
Concentration is 1-30mg/L；When thimerosal is for when being injected intravenously, the concentration of hydroxyl radical free radical to be 1-20mg/L.
Further, when thimerosal is for will not only consider O in injection when being injected intravenously3It is dense with hydroxyl radical free radical
Degree, it is often more important that O3With hydroxyl radical free radical aqueous solution can not direct injection in live pig vein, need to O3With hydroxyl radical free radical water
Solution is handled, and when mixing it with blood, will not make to generate permeable pressure head in blood.Particularly, when thimerosal is for quiet
Ingredient when arteries and veins is injected, in thimerosal further include: NaCl；Mass percent of the NaCl in thimerosal is 0.01%~1%.
Optionally, the ingredient of thimerosal can also include but is not limited to include: serum antibody, cold and raising immunity peptide, canavalin and
The combination of any one or more in cytotripeptide.Ingredient above will not be by O3It is aoxidized with hydroxyl radical free radical, to prevent
O in consumption of chemical reaction aqueous solution3With the content of hydroxyl radical free radical, sterilization and therapeutic effect are influenced, or even generates harmful substance,
And there are treatment or nursing function to live pig body.It is understood that serum antibody can be injection, freeze-dried powder, oral agents.
Thimerosal beneficial effect in the application is:
(1) using the thimerosal in the application can the growth bad border (colony house, crib, excrement pond etc.) to live pig disappear
Poison, while live pig body (intestines, stomach, blood) is carried out disinfection, treats and being nursed, by way of inside and outside take into account, realize to non-
Comprehensive prevention and control of continent swine fever, guarantee the health of live pig, control the propagation of disease.
(2) while prevention and control ASF, taken into account live pig immunocompetence itself raising, in vivo pathogenic hidden danger elimination with
And certain germs cause the treatment of disease.
(3) O is utilized3Prevention and control are carried out to African swine fever with hydroxyl radical free radical strong oxidizing property, are caused a disease efficiently killing ASFV etc.
It is without any side effects to live pig body while bacterium, without any chemical residual, safety and the meat for not influencing live pig.
(4) cardiovascular system of the protium ingredient in aqueous solution to live pig, nervous system, respiratory system etc. have centainly
Therapeutic effect, can realize treatment to live pig body and health-care efficacy while prevention and control ASF.
For a further understanding of the application, following example two additionally provides above-mentioned thimerosal in prevention and control African swine fever
Using.
Thimerosal for the application effect for verifying the application, the application is tested on the live pig similar in health, weight.
Pig is divided into the application to all the components group, the O of the embodiment one in embodiment3Group, hydroxyl radical free radical group, hydrogen-rich group, blank
Control group, every group is 50, and wherein blank control group is that the control experiment group of thimerosal is not used, and hydrogen-rich group is hydrogen and hydrogen
Ion experiments group.Living environment and sufficient food are provided during test, by thimerosal to the growing environment (circle of each group live pig
House, crib, excrement pond etc.) and pig body carry out cleaning and sterilizing, frequency is three times per day (in the morning, afternoon and evening each primary), while by thimerosal
It is quantitatively added to live pig as the drinking water of live pig and drinks, frequency is three times per day (each primary in the morning, afternoon and evening), examination to be counted after 45 days
The incidence of pig in each group in the phase is tested, and counts the infection rate (being shown in Table 1) of each group African swine fever.
Table 1
| Test grouping | Sum | Infect head number | Infection rate |
| Blank control group | 50 | 8 | 16% |
| O3Group | 50 | 3 | 6% |
| Hydroxyl radical free radical group | 50 | 3 | 6% |
| Hydrogen-rich group | 50 | 7 | 14% |
| O3, hydroxyl radical free radical, hydrogen and hydrogen ion | 50 | 1 | 2% |
Illustrate: in above-mentioned test group, O3Ozone content in group are as follows: 25ppm, hydroxyl radical free radical contains in hydroxyl radical free radical group
Amount are as follows: 25mg/L, hydrogen and hydrionic theoretical content in hydrogen-rich group are as follows: 20mg/L, O3, hydroxyl radical free radical, hydrogen and hydrogen from
In subgroup, O3, hydroxyl radical free radical, hydrogen and the corresponding content of hydrogen ion are as follows: 25ppm, 25mg/L, 20mg/L.
Test result refering to upper table is it is found that the thimerosal in the present embodiment can guarantee the effective prevention and control of African swine fever
Live pig health, controls the propagation of disease, produces excellent results to prevention and control African swine fever.
Present invention also provides a kind of disinfectant preparation apparatus, the preparation for the thimerosal in above-described embodiment, comprising:
Water tank and the electrolysis unit being set to inside water tank.
The above is only the preferred embodiment of the application, it is noted that for the ordinary skill people of the art
For member, under the premise of not departing from the application principle, several improvements and modifications can also be made, these improvements and modifications are also answered
It is considered as the protection scope of the application.
Claims (10)
1. a kind of thimerosal for prevention and control African swine fever, which is characterized in that the thimerosal is obtained by water electrolysis；
The matrix composition of the thimerosal is water, contains O in the water3, hydroxyl radical free radical, hydrogen and hydrogen ion.
2. the thimerosal according to claim 1 for prevention and control African swine fever, which is characterized in that the O3Concentration is 0.1-
50ppm。
3. the thimerosal according to claim 2 for prevention and control African swine fever, which is characterized in that the O3Concentration is 0.4-
50ppm。
4. the thimerosal according to claim 2 for prevention and control African swine fever, which is characterized in that the O3Concentration is 0.1-
20ppm。
5. the thimerosal according to claim 1 for prevention and control African swine fever, which is characterized in that the hydroxyl radical free radical
Concentration are as follows: 1-50mg/L.
6. the thimerosal according to claim 5 for prevention and control African swine fever, which is characterized in that the hydroxyl radical free radical
Concentration is 1-30mg/L.
7. the thimerosal according to claim 5 for prevention and control African swine fever, which is characterized in that the hydroxyl radical free radical
Concentration is 1-20mg/L.
8. the thimerosal according to claim 7 for prevention and control African swine fever, which is characterized in that in the thimerosal at
Point further include: NaCl；
Mass percent of the NaCl in the thimerosal is 0.01%~1%.
9. the thimerosal according to any one of claim 1 to 8 for prevention and control African swine fever, which is characterized in that described
The ingredient of thimerosal further includes at least one of:
Serum antibody, cold and raising immunity peptide, canavalin and cytotripeptide.
10. a kind of disinfectant preparation apparatus, special for the preparation of thimerosal according to any one of claims 1 to 9
Sign is, comprising: water tank and the electrolysis unit being set to inside water tank.
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