CN110227127A - Application of the support type phosphorus sodium calcium silicate in preparation treatment skin mucosa injury drug - Google Patents

Application of the support type phosphorus sodium calcium silicate in preparation treatment skin mucosa injury drug Download PDF

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Publication number
CN110227127A
CN110227127A CN201910319609.8A CN201910319609A CN110227127A CN 110227127 A CN110227127 A CN 110227127A CN 201910319609 A CN201910319609 A CN 201910319609A CN 110227127 A CN110227127 A CN 110227127A
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calcium silicate
sodium calcium
phosphorus sodium
extract
powder
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CN110227127B (en
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张劲松
朱礼飞
陈萍
毛加萍
李保芝
易永刚
张宇辰
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Zhejiang Lanzhi Biotechnology Co.,Ltd.
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Nantong Bluewisdom New Material Co Ltd
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    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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Abstract

A kind of application of the support type phosphorus sodium calcium silicate provided by the invention in preparation treatment skin mucosa injury drug.The present invention is by the microcellular structure and sustained release feature of design phosphorus sodium calcium silicate, so that both effectiveness ingredient (including phosphorus sodium calcium silicate) is all gradually to discharge its effect, guarantees stable structure while activity to ensure the preparation yield rate of drug；Several components matchings play synergistic effect, can effectively treat skin mucosa injury, anti-inflammatory to deoil, pox-eliminating whitening, long-acting cleaning skin, mild non-stimulated, Environmental Safety.

Description

Application of the support type phosphorus sodium calcium silicate in preparation treatment skin mucosa injury drug
Technical field
The present invention relates to pharmaceutical technology fields, particularly relate to support type phosphorus sodium calcium silicate in preparation and treat skin mucosa injury Application in drug.
Background technique
Phosphorus sodium calcium silicate also known as bioactivity glass make aqueous cream kind product using straight plus powder mode, it is easy to PH value is allowed to be climbed to 8.5 or more national standard, simultaneously as phosphorus sodium calcium silicate is contacted with water, meeting last decomposition releases alkalinity, PH is adjusted within 8.5 even if just making, and still results in the product being ready for and pH value occurs and constantly rises to 9 or more The problem of.On the one hand this pH, which rises problem, causes product consistency that thinning phenomenon occurs, on the one hand will appear the product such as rejected product Geological Problems.The activity and validity of phosphorus sodium calcium silicate had how not only been maintained, but also can solve the problem and have become a hot topic of research problem.
Summary of the invention
In view of the foregoing, it is necessary to a kind of improved support type phosphorus sodium calcium silicate is provided, as phosphorous sodium calcium silicate Makeup/drug stoste material, had not only kept activity of the phosphorus sodium calcium silicate in cosmetics/drug, but also fast and easy to be added to makeup It is used in product/drug, without having to worry about pH excessive problem.
A kind of application of support type phosphorus sodium calcium silicate in preparation treatment skin mucosa injury drug.
Technical solution provided by the invention are as follows: a kind of support type phosphorus sodium calcium silicate, the support type phosphorus sodium calcium silicate include Modified phosphorus sodium calcium silicate, and the fullerene and extract that hydrogen bond combines are formed with hydroxyl in the modified phosphorus sodium calcium silicate, Wherein the modified phosphorus sodium calcium silicate, which has, runs through micropore and hydroxyapatite structure surface layer.
Further, the pore diameter range through micropore is 1-200nm.
Further, the particle size range of the modified phosphorus sodium calcium silicate is 1-200 μm.
Further, the fullerene is water-soluble, using including cyclodextrin, isostearic acid, polyvinylpyrrolidone Ketone, Methoxyamino are poly ethyldiol modified to obtain the fullerene.
Further, the extract includes one of industrial hemp extract, oat extract, hamamelis extract Or it is a variety of.
The present invention also provides a kind of preparation methods of support type phosphorus sodium calcium silicate, comprising the following steps:
Weigh the phosphorus sodium calcium silicate that particle size range is 1-200 μm；
It is formed on the phosphorus sodium calcium silicate and runs through micropore；
By in the aqueous solution that there is the phosphorus sodium calcium silicate through micropore to be dipped into simulation synthetic perspiration, duration model is impregnated Enclosing is 0.5-6 days, until surface layer forms hydroxyapatite structure, obtains modified phosphorus sodium calcium silicate powder；
Default extract is added in the modified phosphorus sodium calcium silicate powder to sufficiently react, then ball milling, and constantly plus Enter fullerene and deionized water, support type phosphorus sodium calcium silicate powder is made after drying, wherein hydroxyl in the modified phosphorus sodium calcium silicate Base forms hydrogen bond with fullerene and default extract and combines.
Further, the pore diameter range through micropore is 1-200nm；The default extract includes that industrial hemp mentions It takes one of object, oat extract, hamamelis extract or a variety of is re-dubbed.
Further, described to include: through the step of micropore in formation on the phosphorus sodium calcium silicate
Using phosphorus sodium calcium silicate described in laser irradiation or microwave heating, form it into through micropore.
Further, the immersion duration range is 3-4 days.
Further, described by the aqueous solution that there is the phosphorus sodium calcium silicate through micropore to be dipped into simulation synthetic perspiration In, until surface layer forms hydroxyapatite structure, after obtaining the step of being modified phosphorus sodium calcium silicate powder, the method is also wrapped It includes:
Obtained modification phosphorus sodium calcium silicate powder is added in deionized water and is cleaned by ultrasonic several times, is then obtained by filtration clear Modification phosphorus sodium calcium silicate powder after washing, wherein cleaning duration range is 1-20min every time.
Further, described to sufficiently react, then that default extract is added in the modified phosphorus sodium calcium silicate powder Ball milling, and the step of being continuously added fullerene and deionized water, support type phosphorus sodium calcium silicate powder is made after drying includes:
Default extract is added in the modified phosphorus sodium calcium silicate powder, keeps the two sufficiently anti-by heating certain time length It answers, a ball milling 0.1-24h；Then the fullerene of preset dose is added and is continuously added deionized water, secondary ball milling 0.01- 48h；By the mixture after secondary ball milling, support type phosphorus sodium calcium silicate powder is made in drying at 20-150 DEG C.
The present invention also provides a kind of cosmetics, including above-mentioned support type phosphorus sodium calcium silicate, have anti-inflammatory anti-acne, deoil, The effect of cleaning and moist whitening.
Compared with prior art, the present invention is by designing the microcellular structure of phosphorus sodium calcium silicate and being sustained feature, so that effect Property ingredient (including phosphorus sodium calcium silicate) be all gradually to discharge its effect, guarantee activity while stable structure with ensure cosmetics/ The preparation yield rate of drug；Several components matchings play synergistic effect, can effectively treat skin mucosa injury, anti-inflammatory to deoil, Long-acting cleaning skin, while the effect of play whitening, within the scope of reasonable volume, do not show dark toxicity and phototoxicity, ring It ensures safety.
Detailed description of the invention
The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.
Fig. 1 is the preparation flow figure of support type phosphorus sodium calcium silicate in a better embodiment of the invention.
Fig. 2 is that the dermal melanin of support type phosphorus sodium calcium silicate product and control group contains in a better embodiment of the invention Measurement attempts.
Description of symbols:
Nothing.
The embodiment of the present invention that the following detailed description will be further explained with reference to the above drawings.
Specific embodiment
In order to be more clearly understood that the above objects, features, and advantages of the embodiment of the present invention, with reference to the accompanying drawing and The present invention will be described in detail for specific embodiment.It should be noted that in the absence of conflict, the embodiment party of the application Feature in formula can be combined with each other.
Embodiment in the following description, numerous specific details are set forth in order to facilitate a full understanding of the present invention, described reality Applying mode is only some embodiments of the invention, rather than whole embodiments.Based on the embodiment in the present invention, originally Field those of ordinary skill every other embodiment obtained without making creative work, belongs to this hair The range of bright embodiment protection.
Herein " oat extract ": for the herb extract of gramineae plant oat, mainly containing beta glucan and Huang Ketone compounds and a variety of oxidation resistant substances, possess excellent senile-resistant efficacy, can smooth fine wrinkles, improve skin line Reason degree.
Herein " industrial hemp extract ": main chemical compositions are cannabidiol (abbreviation CBD), are extracted from industrial big Numb plant is the non-additive ingredient in industrial hemp, has the pharmacological actions such as anti-spasm, antianxiety, anti-inflammatory.Industry used is big CBD content is far below 0.3gKg in nettle extract-1。
Herein " hamamelis extract ": being obtained by being extracted from primary witch hazel shrub bark and branches and leaves in North America. This extract has hemostasis and anti-inflammatory property, therefore is the common formula components of many natural skin care products.Hamamelis extract It is frequently used for shin moisturizer, shaving cream, astringent, toner and facial cleansing agent etc..
Herein " cyclodextrin ": English name Cyclodextrin, abbreviation CD are that amylose is generated by bacillus A series of lower cyclic oligosaccharides generated of cyclodextrin glycosyltransferase effect general name, usually contain 6~12 D- pyrroles Glucopyranoside unit.
Unless otherwise defined, all technical and scientific terms used herein and the technology for belonging to the embodiment of the present invention The normally understood meaning of the technical staff in field is identical.Term as used herein in the specification of the present invention is intended merely to The purpose of specific embodiment is described, it is not intended that in the limitation embodiment of the present invention.
Referring to Fig. 1, mainly including for the preparation flow of support type phosphorus sodium calcium silicate in a better embodiment of the invention Following steps:
Step S1: the phosphorus sodium calcium silicate that particle size range is 1-200 μm is weighed.Wherein phosphorus sodium calcium silicate can be killed more than 19 The bacterium of kind.
Step S2: it is formed on the phosphorus sodium calcium silicate and runs through micropore.
In present embodiment, the pore diameter range through micropore is 1-200nm.It can be added using laser irradiation or microwave Hot mode, so that micropore should be run through by being formed on the phosphorus sodium calcium silicate.
Step S3: it by the aqueous solution that there is the phosphorus sodium calcium silicate through micropore to be dipped into simulation synthetic perspiration, soaks Steeping duration range is 0.5-6 days, until surface layer forms hydroxyapatite structure, obtains modified phosphorus sodium calcium silicate powder.This step Part is carried out with phosphorus sodium calcium silicate using simulation synthetic perspiration to react, and controls the time of its reaction, it is ensured that its Surface Creation band is micro- Hole and stratiform class hydroxyapatite structure.It is appreciated that if needing so that phosphorus sodium calcium silicate is all degraded in synthetic perspiration, according to The particle size of phosphorus sodium calcium silicate needs the different time.Synthetic perspiration's reference formulation table is as follows:
Order is added Reagent Additional amount (g/L)
1 NaCl 7.996
2 NaHCO3 0.350
3 KCl 0.224
4 K2HPO4·3H2O 0.228
5 MgCl2·6H2O 0.305
6 HCl(1N) 40ml
7 CaCl2 0.278
8 Na2SO4 0.074
9 NH2(CH2OH)3 6.057
In present embodiment, the preferred immersion duration range is 3-4 days.
In present embodiment, after step S3, the method also includes step S31: the modification phosphorus sodium calcium silicate that will be obtained Powder, which is added in deionized water, to be cleaned by ultrasonic several times, the modification phosphorus sodium calcium silicate powder after cleaning is then obtained by filtration, wherein Cleaning duration range is 1-20min every time.
Step S4: default extract being added in the modified phosphorus sodium calcium silicate powder to sufficiently react, then ball milling, and It is continuously added fullerene and deionized water, support type phosphorus sodium calcium silicate powder is made after drying, wherein the modified phosphorus sodium metasilicate Hydroxyl forms hydrogen bond with fullerene and default extract and combines in calcium, to stablize and fix fullerene, while loading richness Le alkene sphere structure, equally can be with the stability in reinforcement structure for the phosphorus sodium calcium silicate system of polyion.By loading work Skill can be improved the availability of biomaterial and play synergistic effect, avoided completely using organic solvents such as toluene, dimethylbenzene (common solvent of fullerene), environmental friendly and safe, toxic side effect is small, and production cost decreases.
In present embodiment, the default extract includes industrial hemp extract, oat extract, hamamelis extract One of or a variety of be re-dubbed.
In present embodiment, the fullerene be it is water-soluble, using include cyclodextrin, isostearic acid, polyvinyl pyrrole Pyrrolidone, Methoxyamino are poly ethyldiol modified to obtain the fullerene.Fullerene ball is small in size, can be used as be supported completely Object is entered in the phosphorus sodium calcium silicate frame with micropore with network blackboard.The fullerene ingredient can be strongly anti-oxidant, has excellent Different free radical scavenging ability, and have inhibiting effect to active oxygen, using after its product use can anti-aging, restore skin Vigor, there are also certain whitening effects.
In present embodiment, step S4 specifically includes: that the modified phosphorus sodium calcium silicate powder is added in default extract In, make the two sufficiently reaction, a ball milling 0.1-24h by heating certain time length；Then be added preset dose fullerene and It is continuously added deionized water, secondary ball milling 0.01-48h；By the mixture after secondary ball milling, dry be made is born at 20-150 DEG C Load type phosphorus sodium calcium silicate powder.
The molding support type phosphorus sodium calcium silicate powder of the above method passes through class hydroxyapatite and phosphorus sodium calcium silicate chemistry knot Hydroxyl in polyhydroxy structure in structure, with fullerene or default extract forms a large amount of hydrogen bond, to stablize and fix Fullerene and default extract, and the sustained release feature of microcellular structure and phosphorus sodium calcium silicate is combined, so that the reasonable composition benefit of load With, and there is synergistic effect between several ingredients, using effect is substantially better than single use or the direct combination of several effects. Detailed preparation step is illustrated with specific embodiment below:
Embodiment 1
(1) take partial size in 1nm to 150 μm of phosphorus sodium calcium silicate, preferably the phosphorus sodium calcium silicate of 45S5 type and 58S type.It is preferred Phosphorus sodium calcium silicate of the partial size within 10 μm.
(2) laser irradiation is carried out using powder of the laser machine to phosphorus sodium calcium silicate, phosphorus sodium calcium silicate can be penetrated by producing Aperture be 1nm-100 μm of nanometer micropore.
(3) the phosphorus sodium calcium silicate with micropore is dipped into the aqueous solution of simulation synthetic perspiration, soaking time 1-10 It, filter infusion liquid obtains modified phosphorus sodium calcium silicate powder.
It wherein, include: that deionized water is added in modified phosphorus sodium calcium silicate powder to form turbid solution after abovementioned steps, it will It is cleaned 3 times in turbid solution merging ultrasonic drilling machine, 1-5 minutes each, the modification phosphorus sodium calcium silicate after being cleaned after filtering again Powder.
(4) 10 μm of 1000g partial size of modification phosphorus sodium calcium silicate powder is taken, 0.01-200g industrial hemp is added wherein and mentions Take object, be placed in micro-wave oven, heated, heating power between 600W to 800W, when heating a length of 1s to 200s (this is Because microwave energy promotes the combination of the cannabidiol CBD in the hydroxyl and industrial hemp extract of phosphorus sodium calcium silicate, wherein CBD Content is in 0.01g.Kg-1).The CBD of load has anti-inflammatory efficacy, facilitates anti-inflammatory anti-acne.
(5) after powder final in step (4) being taken out, high speed grinding 0.1 hour to 24 hours in the ball mill.In turn Water-soluble fullerene derivate 0.01g is added wherein, continues grinding 0.01 hour to 48 hours.It is continuously added in grinding Ionized water, total amount 0.01ml to 1L.The fullerene of load can effectively remove free radical, reach white-skinned face function.
(6) powder after final grinding is taken out in step (5), is dried, obtains in the baking oven of 20-150 degrees Celsius of merging Support type phosphorus sodium calcium silicate, i.e. load class hydroxyapatite/industrial hemp extract/fullerene modification phosphorus sodium metasilicate calcium powder End.The ingredient of multi-load has synergistic effect, so that whitening and anti-acne effect are more preferable, is used as cream kind and facial mask class cosmetics It can moisten for a long time and skin whitening and anti-inflammatory anti-acne, be also used as the drug of repairing and treating skin mucosa injury.
Using cream kind made of above-mentioned support type phosphorus sodium calcium silicate and facial mask class product (including cosmetics or drug), with The whitening effect of control group has carried out contrastive test.The simple cosmetic mask using fullerene that the control group refers to, such as Most simple formula, main component are fullerene 1ppm to 1000ppm, xanthan gum 0.3%, hyaluronic acid 0.01%, amino acid guarantor Humectant 0.03%, benzalkonium chloride 0.001%, other compositions are water.Moreover, control group quantity and test group quantity is all in test It is 30.
Skin color measurement is analysis whitening effect than more objective method.Skin color tester is used in test Colorimeter CL400 is measured L* value, in Lab colorimeter system, the brightness of L* reflection color, i.e., from white to black Color change, L* value is bigger, and color is more biased to white, otherwise is biased to black.Use facial area spot after two kinds of product different times Skin brightness results are shown in Table 1 at point.As can be seen that in 9 weeks test periods, after subject is using control set product, tested region Skin whiteness value has slow raising trend, and uses the tested area skin whiteness value of test set product significantly raised, application 23.0 software of SPSS carries out normal distribution analysis to data, and statistical result meets normal distribution.Product of the invention is the 9th Zhou Shi, paired t-test is as a result, there are significant difference (P < 0.05) before relative usage；Control group each test point within 9 weeks, phase To paired t-test before using as a result, there are no significant difference (P > 0.05).
Table 1
Also using dermal melanin and ferroheme tester, (MexameterMX18, German CK electronics corporation are raw in test Produce) melanin content before and after test group and control group use is detected, as shown in Figure 2.As can be seen that control group and Test set product after use, the substantially linear decline of melanin content, wherein using after 80 days, using control set product by Examination area skin melanin content falls to original 80%；And use the tested area skin melanin content of product of the present invention Original 60% is fallen to, compared to control set product, faster, more preferably, effect is excellent after the load of surface multi-use ingredient for whitening effect In the effect of single component, the sum of the effect of also superior to multiple formulations.
Embodiment 2
(1) 150 μm of partial size of phosphorus sodium calcium silicate 1000g, preferably the phosphorus sodium calcium silicate of 45S5 type and 58S type are taken.
(2) microwave heating phosphorus sodium calcium silicate powder is used, it is 1nm-100 that the aperture of phosphorus sodium calcium silicate can be penetrated by, which producing, μm nanometer micropore.
(3) the phosphorus sodium calcium silicate with micropore is dipped into the aqueous solution of simulation synthetic perspiration, soaking time 3-8 It, filter infusion liquid obtains modified phosphorus sodium calcium silicate powder.
It wherein, include: that deionized water is added in modified phosphorus sodium calcium silicate powder to form turbid solution after abovementioned steps, it will It is cleaned 3 times in turbid solution merging ultrasonic drilling machine, 1-20 minutes each, the modification phosphorus sodium calcium silicate after being cleaned after filtering again Powder.
(4) the modified phosphorus sodium calcium silicate powder of 100g is taken, 0.01-200g oat extract is added wherein, is placed in micro-wave oven In, carry out the time that 1s to 200S is heated under mid power；After taking-up, high speed grinding 0.1 hour to 24 hours in the ball mill. And then water-soluble fullerene derivate 0.01g is added wherein, continue grinding 0.01 hour to 48 hours.Constantly add in grinding Enter deionized water, total amount 0.01ml to 1L.Powder after grinding is taken out, is carried out in the vacuum oven of 20-150 degrees Celsius of merging Drying is removed water, support type phosphorus sodium calcium silicate is obtained, is i.e. load class hydroxyapatite/oat extract/fullerene modification phosphorus silicon Sour sodium calcium powder.
Embodiment 3
(1) 10 μm of phosphorus sodium calcium silicate, preferably the phosphorus sodium calcium silicate of 45S5 type and 58S type are taken.
(2) laser irradiation is carried out using powder of the laser machine to phosphorus sodium calcium silicate, phosphorus sodium calcium silicate can be penetrated by producing Aperture be 2 μm of nanometer micropore.
(3) the phosphorus sodium calcium silicate with micropore is dipped into the aqueous solution of simulation synthetic perspiration, soaking time 3-4 It, filter infusion liquid obtains modified phosphorus sodium calcium silicate powder.
It wherein, include: that deionized water is added in modified phosphorus sodium calcium silicate powder to form turbid solution after abovementioned steps, it will It is cleaned 3 times in turbid solution merging ultrasonic drilling machine, 1-20 minutes each, the modification phosphorus sodium calcium silicate after being cleaned after filtering again Powder.
(4) the modified phosphorus sodium calcium silicate powder of 100g is taken, 0.01-200g hamamelis extract is added wherein and hemp is extracted The compounding extract of object is placed in micro-wave oven, carries out the time that 1s to 200S is heated under mid power；After taking-up, in ball mill High speed is ground 0.1 hour to 24 hours.And then water-soluble fullerene derivate 0.01g is added wherein, continue to grind 0.01 hour to 48 hours.Deionized water, total amount 0.01ml to 1L are continuously added in grinding.Take out powder after grinding, merging Water removal drying is carried out in 20-150 degrees Celsius of vacuum oven, obtains support type phosphorus sodium calcium silicate, i.e. load class hydroxy-apatite Stone/hamamelis extract/industrial hemp extract/fullerene modification phosphorus sodium calcium silicate powder.
Meta-alkalescence face cream class cosmetics/drug that pH is lower than 8.5 is made using product in the present embodiment, carries out anti-acne effect The experiment of half face.Experimentation are as follows: trial volunteer 60, the half of face in the left and right of each people, one side of something uses product of the present invention (i.e. Test group), another one side of something, which is only washed one's face with clear water, to be compareed and (cleans face with facial cleanser before use).In test process, Itch, scorching hot and tingling sensation are not found, but have 3 " quick-fried acnes " for the short time occur (recovery from illness in surrounding), erythema 1, other It is all asymptomatic.As can be seen that product of the present invention anti-acne effect is obvious, obvious anti-acne can be fully recovered or showed within mostly 10 days or so Effect, number are 26 people and 30 people respectively, account for the 43.33% and 50% of test total number of persons, and product of the present invention is without function and effect It is 0 people；And control group lasts 3 weeks or so, recovery from illness number is 0 people, shows obvious anti-acne effect only 5 people, accounts for the total people of test Several 8.33%.To sum up, the anti-acne effect environmental protection of product of the present invention, appropriate is high, and anti-acne effect is significant, treats mucocutaneous The effect of damage, is obvious.In addition, product of the present invention can be adhered to due to its meta-alkali characteristic using for length with long-acting cleaning skin The damaged skins such as acne skin or hormone allergy have to deoil and cleaning effect well, can effectively prevent small pox recurrence.
In other embodiments, the composition of support type phosphorus sodium calcium silicate of the invention, composition raw material and composition raw material Proportion and technological parameter etc. be not limited to embodiment of above.Embodiment of above and using formula of the invention and match method Manufactured cosmetics/drug, whitening, anti-acne and reparation skin mucosa injury effect can reach the above-mentioned experiment effect enumerated Fruit.
It is used as slow-releasing system about phosphorus sodium calcium silicate (bioactivity glass), main feature is: (1) high local concentrations, It is few to be supported object dosage for whole body low concentration；(2) initial stage burst size is high (discharge about 10-15% for the first time and be supported amount of substance), quickly Switch to low concentration and stablize release, being supported length object deenergized period (at 8-10 days, for lesion type ulcerous skin, can abandon Wash one's face cleaning)；(3) replacement or reparative regeneration skin maintain skin contours and function.
The principle of sustained release is: phosphorus sodium calcium silicate (bioactivity glass) be implanted in touch human body fluid, or contact To after skin surface body fluid or moisture, body fluid or moisture are from micropore infiltration carrier, so that being supported object dissolution.Since carrier is (raw Object activity glass) it is inside and outside there is the concentration difference for being supported object, be supported object such as fullerene or plant extracts can gradually from The high concentration of carrier inside is to external low concentration disperse, until all releasing carrier.And bioactivity glass itself also exists It gradually degrades during release, according to different particle size and pore size, the sustained release period can be extended to 15 days from 8 days.Eventually Point situation is that bioactivity glass is all degraded, and shape avalanche and fully enters body fluid, is supported object and finally obtains whole releases, Newly-generated new skin is had simultaneously to occur.
To sum up, cosmetics/drug is made in support type phosphorus sodium calcium silicate of the invention, comprising a effective amount of fullerene clusters and The acceptable carrier of human body skin quality, by the microcellular structure of phosphorus sodium calcium silicate and sustained release feature so that both effectiveness ingredient be all by Its effect is gradually discharged, for skin damage histocyte being repaired, having positive association to free radical resisting, anti-inflammatory, antibacterial and sterilization Same-action has extraordinary anti-acne effect especially with anti-acne cream, anti-acne essence and the Deacne pack that it makes.
Embodiment of above is only to illustrate the technical solution of the embodiment of the present invention rather than limits, although referring to above preferable The embodiment of the present invention is described in detail in embodiment, those skilled in the art should understand that, it can be to this hair The technical solution of bright embodiment is modified or equivalent replacement should not all be detached from the embodiment of the present invention technical solution spirit and Range.

Claims (10)

1. a kind of application of support type phosphorus sodium calcium silicate in preparation treatment skin mucosa injury drug.
2. application according to claim 1, which is characterized in that the preparation method of the support type phosphorus sodium calcium silicate includes:
Weigh phosphorus sodium calcium silicate；
It is formed on the phosphorus sodium calcium silicate and runs through micropore；
By in the aqueous solution that there is the phosphorus sodium calcium silicate through micropore to be dipped into simulation synthetic perspiration, impregnating duration range is 0.5-6 days, until surface layer forms hydroxyapatite structure, obtain modified phosphorus sodium calcium silicate powder；
Default extract is added in the modified phosphorus sodium calcium silicate powder to sufficiently react, then ball milling, and is continuously added richness Strangle alkene and deionized water, support type phosphorus sodium calcium silicate powder be made after drying, wherein in the modified phosphorus sodium calcium silicate hydroxyl with Fullerene and default extract form hydrogen bond and combine.
3. application according to claim 2, it is characterised in that: described to be formed on the phosphorus sodium calcium silicate through micropore Step includes:
Using phosphorus sodium calcium silicate described in laser irradiation or microwave heating, form it into through micropore.
4. application according to claim 2, it is characterised in that: the pore diameter range through micropore is 1-200nm.
5. application according to claim 2, it is characterised in that: described by described to there is the phosphorus sodium calcium silicate through micropore to soak In the aqueous solution for steeping simulation synthetic perspiration, until surface layer forms hydroxyapatite structure, modified phosphorus sodium calcium silicate powder is obtained The step of after, the method also includes:
Obtained modification phosphorus sodium calcium silicate powder is added in deionized water and is cleaned by ultrasonic several times, after cleaning then is obtained by filtration Modification phosphorus sodium calcium silicate powder, wherein every time cleaning duration range be 1-20min.
6. application according to claim 2, which is characterized in that described that the modified phosphorus sodium metasilicate is added in default extract To sufficiently react in calcium powder, then ball milling, and it is continuously added fullerene and deionized water, support type phosphorus silicic acid is made after drying The step of sodium calcium powder includes:
Default extract is added in the modified phosphorus sodium calcium silicate powder, the two sufficiently reaction, a ball milling are made by heating 0.1-24h；Then the fullerene of preset dose is added and is continuously added deionized water, secondary ball milling 0.01-48h；By secondary ball Mixture after mill dries obtained support type phosphorus sodium calcium silicate powder at 20-150 DEG C.
7. application according to claim 2, it is characterised in that: the immersion duration range is 3-4 days.
8. application according to claim 2, it is characterised in that: the particle size range of the phosphorus sodium calcium silicate is 1-200 μm.
9. application according to claim 2, it is characterised in that: the default extract includes industrial hemp extract, swallow One of wheat extract, hamamelis extract are a variety of.
10. application according to claim 2, it is characterised in that: the fullerene is water-soluble, the fullerene use Including cyclodextrin, isostearic acid, polyvinylpyrrolidone, Methoxyamino is poly ethyldiol modified obtains the fullerene.
CN201910319609.8A 2019-04-19 2019-04-19 Application of load type calcium sodium phosphosilicate in preparation of medicine for treating skin mucosa injury Active CN110227127B (en)

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CN1160996A (en) * 1995-06-13 1997-10-01 Z·曼索尔 Methods of delivering materials into the skin, and compositions used therein
CN1455661A (en) * 2000-03-27 2003-11-12 肖特玻璃制造厂 New cosmetic, personal care, cleaning agent and nutritional supplement compositions containg bioactive glass and methods of making and using same
US20040166172A1 (en) * 2001-03-27 2004-08-26 Coni Rosati Bioctive tissue abrasives
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CN101522164A (en) * 2006-09-13 2009-09-02 提升肤质产品公司 Cosmetic composition for the treatment of skin and methods thereof
CN102885698A (en) * 2012-04-20 2013-01-23 张晓金 Ultra-micro colloidal powder with core- shell structure and preparation method and application thereof
CN104415399A (en) * 2013-09-10 2015-03-18 中国科学院宁波材料技术与工程研究所 Hydroxyapatite/graphene nano-composite powder and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1160996A (en) * 1995-06-13 1997-10-01 Z·曼索尔 Methods of delivering materials into the skin, and compositions used therein
CN1455661A (en) * 2000-03-27 2003-11-12 肖特玻璃制造厂 New cosmetic, personal care, cleaning agent and nutritional supplement compositions containg bioactive glass and methods of making and using same
US20040166172A1 (en) * 2001-03-27 2004-08-26 Coni Rosati Bioctive tissue abrasives
CN1813657A (en) * 2005-12-15 2006-08-09 孙振淋 Application method of nano calcium phosphate like salt for cosmetic product
CN101522164A (en) * 2006-09-13 2009-09-02 提升肤质产品公司 Cosmetic composition for the treatment of skin and methods thereof
CN102885698A (en) * 2012-04-20 2013-01-23 张晓金 Ultra-micro colloidal powder with core- shell structure and preparation method and application thereof
CN104415399A (en) * 2013-09-10 2015-03-18 中国科学院宁波材料技术与工程研究所 Hydroxyapatite/graphene nano-composite powder and preparation method thereof

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