CN110227089A - A kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules - Google Patents
A kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules Download PDFInfo
- Publication number
- CN110227089A CN110227089A CN201910598208.0A CN201910598208A CN110227089A CN 110227089 A CN110227089 A CN 110227089A CN 201910598208 A CN201910598208 A CN 201910598208A CN 110227089 A CN110227089 A CN 110227089A
- Authority
- CN
- China
- Prior art keywords
- root
- granules
- preparation technology
- dahurain angelica
- leaf extract
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules, specific step is as follows: raw material extracts: will choose angelica root diameter leaf, it is ground into coarse powder, the coarse powder that above-mentioned steps are obtained is put into extractor, the ethyl alcohol of 40-50 parts by weight is added to extractor, stop heating after being heated to 60 DEG C of temperature leachings 1-1.5 hours to impregnate 3 hours, heating and temperature control is extracted 1 hour in 75-78 DEG C of beginning timed reflux again, and extracting solution is delivered to medical fluid storage tank.The present invention is during raw material extracts, according to the property of angelica root, in conjunction with chemistry and pharmacodynamics index, it is extracted using extractor, use water as solvent in contrast to traditional as solvent by the ethyl alcohol of addition 50% -60%, effectively raise the recovery rate of general coumarin in angelica root, and once reflux and secondary back are set, effectively increase the extraction efficiency of angelica root diameter interlobar part extracting solution, secondly the root of Dahurain angelica stem-leaf extract Preparation Technology of Granules, also add drying, whole grain and packaging step, so that after the completion of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules preparation, it can sell, and the root of Dahurain angelica stem-leaf extract Preparation Technology of Granules technique process is simple, it is convenient to operate, convenient for mass production.
Description
Technical field
The present invention relates to extract particles agent preparation technical field, specifically a kind of root of Dahurain angelica stem-leaf extract granule preparation
Technique.
Background technique
The root of Dahurain angelica, perennial tall and big draft is 1-2.5 meters high, and root is cylindrical, 2-5 centimetres of basal part of stem diameter, one Hui Yuzhuan of basal leaf
Division, universal umbel basidixed or side are raw, and fruit oblong to oval is used as medicine with root, the dehumidifying that gets rid of illness, apocenosis myogenic, work
The functions such as blood and relieving pain.Cure mainly anemofrigid cold, headache, rhinitis, toothache.The diseases such as leukorrhea with reddish discharge, pain furuncle poison, can also make fragrance.North
There are cultivation in some provinces and regions of side, market one's own products more, and minority is adjusted outside the province.Generally be born in hayashishita, border, by small stream, shrubbery and mountain valley grass
Ground.
Existing root of Dahurain angelica stem-leaf extract Preparation Technology of Granules, simple process, the solvent of extraction mostly use water, extraction
Effect is poor, or using the ethyl alcohol greater than 70% concentration as solvent, the volatility coefficient of ethanol solution is higher, leads to production exercise
Make the concentration of alcohol in surrounding air with regard to relatively high, therefore safety coefficient is low, and preparation process is relative complex, is not suitable for big
Amount production,
Summary of the invention
The purpose of the present invention is to provide a kind of root of Dahurain angelica cauline leaf extractions for having both Environmental Safety, extraction efficiency and simple process
Composition granule agent preparation process, to solve the problems mentioned in the above background technology.
To achieve the above object, the invention provides the following technical scheme:
A kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules, the specific steps are as follows:
(1), raw material extracts:
(1.1), angelica root diameter leaf will be chosen, coarse powder is ground into；
(1.3) coarse powder for obtaining above-mentioned steps is put into extractor, and the second of 40-50 parts by weight is added to extractor
Alcohol stops heating after being heated to 60 DEG C of temperature leachings 1-1.5 hours and impregnates 3 hours, and heating and temperature control starts at 75-78 DEG C again
Timed reflux extracts 1 hour, and extracting solution is delivered to medical fluid storage tank；
(1.4), secondary back: to extractor be added 40-50 parts by weight ethyl alcohol, soak at room temperature 1-1.5 hours, again
Heating and temperature control 75-78 DEG C beginning refluxing extraction 1 hour, extracting solution is delivered to medical fluid storage tank and merges extracting solution twice；
(1.5), the extracting solution in medical fluid storage tank is squeezed into and tank progress concentration extraction is concentrated under reduced pressure；
(1.6), cream, extraction process are completed out when root of Dahurain angelica medicinal extract relative density reaches 1.10-1.40
(2) auxiliary material is added:
(2.1), by drug thick paste and auxiliary material set it is suitable be uniformly mixed in container, addition wetting agent is made that " hand is pinched agglomerating, presses
I.e. dissipate " softwood；
(3), it pelletizes:
(3.1), the softwood for being processed into above-mentioned steps is added to oscillating granulator or rotary granulator, then to squeeze
Uniform particle is made by the mesh screen of l4~22 in pressure mode；
(4), dry:
(4.1), the particle that upper above-mentioned steps are processed is sent in drug granule drying machine and is dried, dry
Temperature is 60 DEG C~80 DEG C.
(5), whole grain: by re-sieving after the particle processed in above-mentioned steps cooling, keep particle uniform；
(6), pack: the particle after step (5) are sieved is added to automatic granular packaging machine and dispenses, and packaging bag is answered
Selection is not easy to breathe freely, the packaging material of moisture-inhibiting, such as composite aluminium plastic bag, aluminium foil bag or air-locked plastic bottle, and answers dry storage.
As a further solution of the present invention:
The auxiliary material is one of Icing Sugar, beta-cyclodextrin and gas-producing disintegrant or a variety of mixtures, and the Icing Sugar is can
The excellent excipient of soluble particles agent, and play the role of flavoring and bonding.
As further scheme of the invention:
The beta-cyclodextrin can be by aromatic volatile component powders, then mix and prop up in manufactured particle with other drugs,
It can make liquid medicine powdered, and increase the solubility of oiliness waistline and the stability of granule.
As further scheme of the invention:
The gas-producing disintegrant is made of organic acid and sodium bicarbonate or sodium carbonate.
As further scheme of the invention:
The concentration for the ethyl alcohol that raw material is added during extracting in the step (1) is 50% -60%.
As further scheme of the invention:
In the step (4) during drying, water content is controlled within 2% in the particle after drying.
Compared with prior art, the beneficial effects of the present invention are:
The present invention is during raw material extracts, according to the property of angelica root, in conjunction with chemistry and pharmacodynamics index, using mentioning
It takes tank to extract, uses water as solvent in contrast to traditional as solvent by the ethyl alcohol of addition 50% -60%, effectively
The recovery rate for improving general coumarin in angelica root, and be arranged once reflux and secondary back, effectively increase white
The extraction efficiency of root of Dahurian angelica medicinal material diameter interlobar part extracting solution, secondly the root of Dahurain angelica stem-leaf extract Preparation Technology of Granules, also adds dry
Dry, whole grain and packaging step, so that can sell after the completion of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules preparation,
And the root of Dahurain angelica stem-leaf extract Preparation Technology of Granules technique process is simple, it is convenient to operate, and environmentally friendly degree is high, convenient for a large amount of raw
It produces.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
A kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules, the specific steps are as follows:
(1), raw material extracts:
(1.1), angelica root diameter leaf will be chosen, coarse powder is ground into；
(1.3) coarse powder for obtaining above-mentioned steps is put into extractor, and the second of 40-50 parts by weight is added to extractor
Alcohol stops heating after being heated to 60 DEG C of temperature leachings 1-1.5 hours and impregnates 3 hours, and heating and temperature control starts at 75-78 DEG C again
Timed reflux extracts 1 hour, and extracting solution is delivered to medical fluid storage tank；
(1.4), secondary back: to extractor be added 40-50 parts by weight ethyl alcohol, soak at room temperature 1-1.5 hours, again
Heating and temperature control 75-78 DEG C beginning refluxing extraction 1 hour, extracting solution is delivered to medical fluid storage tank and merges extracting solution twice；
(1.5), the extracting solution in medical fluid storage tank is squeezed into and tank progress concentration extraction is concentrated under reduced pressure；
(1.6), cream, extraction process are completed out when root of Dahurain angelica medicinal extract relative density reaches 1.10-1.40
(2) auxiliary material is added:
(2.1), by drug thick paste and auxiliary material set it is suitable be uniformly mixed in container, addition wetting agent is made that " hand is pinched agglomerating, presses
I.e. dissipate " softwood；
(3), it pelletizes:
(3.1), the softwood for being processed into above-mentioned steps is added to oscillating granulator or rotary granulator, then to squeeze
Uniform particle is made by the mesh screen of l4~22 in pressure mode；
(4), dry:
(4.1), the particle that upper above-mentioned steps are processed is sent in drug granule drying machine and is dried, dry
Temperature is 60 DEG C~80 DEG C.
(5), whole grain: by re-sieving after the particle processed in above-mentioned steps cooling, keep particle uniform；
(6), pack: the particle after step (5) are sieved is added to automatic granular packaging machine and dispenses, and packaging bag is answered
Selection is not easy to breathe freely, the packaging material of moisture-inhibiting, such as composite aluminium plastic bag, aluminium foil bag or air-locked plastic bottle, and answers dry storage.
Auxiliary material is one of Icing Sugar, beta-cyclodextrin and gas-producing disintegrant or a variety of mixtures, and the Icing Sugar is soluble
The excellent excipient of granule, and play the role of flavoring and bonding, beta-cyclodextrin can be by aromatic volatile component powders, then mix
It is even to be propped up in manufactured particle with other drugs, liquid medicine powdered can be made, and increase the solubility and granule of oiliness waistline
Stability, gas-producing disintegrant is made of organic acid and sodium bicarbonate or sodium carbonate.
The concentration for the ethyl alcohol that raw material is added during extracting in step (1) is 50% -60%, drying in step (4)
In the process, water content controls within 2% in the particle after drying.
The present invention is during raw material extracts, according to the property of angelica root, in conjunction with chemistry and pharmacodynamics index, using mentioning
It takes tank to extract, uses water as solvent in contrast to traditional as solvent by the ethyl alcohol of addition 50% -60%, effectively
The recovery rate for improving general coumarin in angelica root, and be arranged once reflux and secondary back, effectively increase white
The extraction efficiency of root of Dahurian angelica medicinal material diameter interlobar part extracting solution, secondly the root of Dahurain angelica stem-leaf extract Preparation Technology of Granules, also adds dry
Dry, whole grain and packaging step, so that can sell after the completion of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules preparation,
And the root of Dahurain angelica stem-leaf extract Preparation Technology of Granules technique process is simple, it is convenient to operate, and is convenient for mass production.
The preferred embodiment of the patent is described in detail above, but this patent is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be under the premise of not departing from this patent objective
Various changes can be made.
Claims (6)
1. a kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules, which is characterized in that specific step is as follows:
(1), raw material extracts:
(1.1), angelica root diameter leaf will be chosen, coarse powder is ground into；
(1.3) coarse powder for obtaining above-mentioned steps is put into extractor, and the ethyl alcohol of 40-50 parts by weight is added to extractor, adds
Heat stops heating and impregnates 3 hours after soaking 1-1.5 hours to 60 DEG C of temperature, heating and temperature control is returned in 75-78 DEG C of beginning timing again
Stream extracts 1 hour, and extracting solution is delivered to medical fluid storage tank；
(1.4), secondary back: the ethyl alcohol of 40-50 parts by weight is added to extractor, soak at room temperature 1-1.5 hours, heats again
Temperature control 75-78 DEG C beginnings refluxing extraction 1 hour, extracting solution is delivered to medical fluid storage tank merging extracting solution twice；
(1.5), the extracting solution in medical fluid storage tank is squeezed into and tank progress concentration extraction is concentrated under reduced pressure；
(1.6), cream, extraction process are completed out when root of Dahurain angelica medicinal extract relative density reaches 1.10-1.40
(2) auxiliary material is added:
(2.1), by drug thick paste and auxiliary material set it is suitable be uniformly mixed in container, wetting agent is added and is made that " hand is pinched agglomerating, presses and is
Dissipate " softwood；
(3), it pelletizes:
(3.1), the softwood for being processed into above-mentioned steps is added to oscillating granulator or rotary granulator, then with extruding side
Uniform particle is made by the mesh screen of l4~22 in formula；
(4), dry:
(4.1), the particle that upper above-mentioned steps are processed is sent in drug granule drying machine and is dried, dry temperature
It is 60 DEG C~80 DEG C.
(5), whole grain: by re-sieving after the particle processed in above-mentioned steps cooling, keep particle uniform；
(6), pack: the particle after step (5) are sieved is added to automatic granular packaging machine and dispenses, and packaging bag should select
It is not easy to breathe freely, the packaging material of moisture-inhibiting, such as composite aluminium plastic bag, aluminium foil bag or air-locked plastic bottle, and answers dry storage.
2. according to a kind of its root of Dahurain angelica stem-leaf extract Preparation Technology of Granules described in claim 1, which is characterized in that described auxiliary
Material is one of Icing Sugar, beta-cyclodextrin and gas-producing disintegrant or a variety of mixtures, the Icing Sugar are the excellent of soluble granule
Good excipient, and play the role of flavoring and bonding.
3. according to a kind of its root of Dahurain angelica stem-leaf extract Preparation Technology of Granules as claimed in claim 2, which is characterized in that the β-
Cyclodextrin can be by aromatic volatile component powders, then mix and prop up in manufactured particle with other drugs, can make liquid medicine powder
Endization, and increase the solubility of oiliness waistline and the stability of granule.
4. according to a kind of its root of Dahurain angelica stem-leaf extract Preparation Technology of Granules as claimed in claim 2, which is characterized in that the bubble
Disintegrating agent is risen to be made of organic acid and sodium bicarbonate or sodium carbonate.
5. according to a kind of its root of Dahurain angelica stem-leaf extract Preparation Technology of Granules described in claim 1, which is characterized in that the step
Suddenly the concentration for the ethyl alcohol that raw material is added during extracting in (1) is 50% -60%.
6. according to a kind of its root of Dahurain angelica stem-leaf extract Preparation Technology of Granules described in claim 1, which is characterized in that the step
Suddenly in (4) during drying, water content is controlled within 2% in the particle after drying.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910598208.0A CN110227089A (en) | 2019-07-04 | 2019-07-04 | A kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910598208.0A CN110227089A (en) | 2019-07-04 | 2019-07-04 | A kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules |
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| CN110227089A true CN110227089A (en) | 2019-09-13 |
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| CN201910598208.0A Pending CN110227089A (en) | 2019-07-04 | 2019-07-04 | A kind of root of Dahurain angelica stem-leaf extract Preparation Technology of Granules |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737569A (en) * | 2022-11-17 | 2023-03-07 | 天地恒一制药股份有限公司 | Preparation method of radix angelicae formula granules |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062069A (en) * | 2007-06-18 | 2007-10-31 | 石任兵 | Whole coumarins extract from root of dahuriae angelica and the preparing method thereof |
| CN104523783A (en) * | 2014-12-11 | 2015-04-22 | 黑龙江仁合堂药业有限责任公司 | Extraction process for large-scale production of radix angelicae extract in medicinal radix angelicae material |
| CN108653348A (en) * | 2018-07-06 | 2018-10-16 | 亳州职业技术学院 | A kind of root of Dahurain angelica stem extraction Preparation Technology of Granules |
-
2019
- 2019-07-04 CN CN201910598208.0A patent/CN110227089A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062069A (en) * | 2007-06-18 | 2007-10-31 | 石任兵 | Whole coumarins extract from root of dahuriae angelica and the preparing method thereof |
| CN104523783A (en) * | 2014-12-11 | 2015-04-22 | 黑龙江仁合堂药业有限责任公司 | Extraction process for large-scale production of radix angelicae extract in medicinal radix angelicae material |
| CN108653348A (en) * | 2018-07-06 | 2018-10-16 | 亳州职业技术学院 | A kind of root of Dahurain angelica stem extraction Preparation Technology of Granules |
Non-Patent Citations (2)
| Title |
|---|
| 杨明: "《中药药剂学》", 31 July 2016, 中国中医药出版社 * |
| 罗永明: "《全国医药类高职高专规划教材 中药化学》", 30 September 2013, 西安交通大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737569A (en) * | 2022-11-17 | 2023-03-07 | 天地恒一制药股份有限公司 | Preparation method of radix angelicae formula granules |
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Application publication date: 20190913 |
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