CN110221445A - Circular polarization orphan generation device and multi-photon micro imaging system - Google Patents
Circular polarization orphan generation device and multi-photon micro imaging system Download PDFInfo
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- G—PHYSICS
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- G—PHYSICS
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- G02B27/286—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising for controlling or changing the state of polarisation, e.g. transforming one polarisation state into another
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Abstract
The present invention relates to a kind of circular polarization orphan generation device and multi-photon micro imaging systems, circular polarization orphan's generation device includes pump laser, the first quarter-wave plate, the first condenser lens and the optical fiber in same optical path, wherein, the line polarisation that the pump laser generates is changed into rotatory polarization after the first quarter-wave plate, rotatory polarization is coupled in the optical fiber after the condenser lens, and rotatory polarization is changed into circular polarization orphan after the optical fiber.By the first quarter-wave plate, line polarisation is made to become rotatory polarization, then rotatory polarization is become to circular polarization orphan after optical fiber.Test proves that, under equal conditions, the energy of circular polarization orphan is 1.56 times of linear polarization orphan's energy, multi-photon signal is transmitted in the brain farther, to enable the mankind further to explore the tissue of brain deep layer, and then unlock the veil of brain mystery.
Description
Technical field
The present invention relates to optical image technology field more particularly to a kind of circular polarization orphan generation device and multi-photon are micro-
Imaging system.
Background technique
Soliton (Soliton, Solitons in optical fibres) refers to by long distance transmission and keeps shape
The constant light pulse of shape.A branch of light pulse includes many different frequency contents, and frequency is different, spread speed in the medium
Dispersion will occur in a fiber for difference, therefore, light pulse, so that pulsewidth broadens.But when the extremely narrow monochromatic light arteries and veins with high intensity
It pours when being mapped in optical fiber, Kerr effect will be generated, i.e. the refractive index of medium changes with luminous intensity, thus causes in light pulse
Middle generation Self-phase modulation, the phase change for generating pulse front edge cause frequency to reduce, the phase change that pulse back edge generates
Frequency is caused to increase, then pulse front edge is propagated slowly than edge thereafter, so that pulsewidth be made to narrow.When pulse has amplitude appropriate
When, both the above effect can be offset just, then pulse can keep waveform stabilization unchangeably to transmit in a fiber, that is, form
Soliton, also referred to as base rank soliton.If impulse amplitude continues to increase, the effect that narrows will be more than the effect that broadens, then form height
Consecutive variations will occur for rank soliton, the pulse shape that it is transmitted in a fiber, and compression first narrows, and then divide, specific
It is restored to pulse period property at distance.
Soliton is by two kinds of most basic physical phenomenons in optical fiber, i.e. group velocity dispersion (GVD) and Self-phase modulation
(SPM) it cooperatively forms.
Certain frequency range is constantly present when light pulse is transmitted in a fiber, in linear approximation, often by light pulse table
It is shown as a series of superposition of monochromatic waves in a certain range.Since each harmonic component phase velocity is different, thus light pulse envelope
Transmission usually indicates (for β as light wave wave number, ω is carrier frequency) using group velocity vg=d ω/d β.By the formula as it can be seen that group velocity is
Change with the variation of frequency, and the component of different frequency can then be propagated at different rates in light pulse, cause
The dispersion of pulse, this phenomenon are referred to as group velocity dispersion (GVD).Research the result shows that, λ d=1310nm at be zero dispersion
Wavelength, λ>λ d are referred to as anomalous dispersion region, and λ<λ d is referred to as normal-dispersion.Normally with the light pulse of anomalous dispersion region
Transmission characteristic is different, and in anomalous dispersion region, the high fdrequency component (blue shift) of light pulse is transmitted compared with low frequency component (red shift)
Fastly, and in normal-dispersion, situation is exactly the opposite.Since transmission situation is different, group velocity dispersion effect is different, eventually leads to
The broadening of light pulse.
Self phase modulation is phase shift caused by light wave itself when light wave transmits in a fiber.Its folding for originating from optical fiber
Penetrate nonlinear effect-Ke Er (kerr) effect between rate n and electric field strength I, it may be assumed that n=n0+n2I.In above formula, n=1.45
It is linear refractive index, n2=6.1 × 1023V/m is nonlinear viscoelastic piles.From the above equation, we can see that the pulse component of varying strength
Phase velocity is different, in this way, will generate different phase shifts during optical pulse propagation, as a result will cause burst spectrum
Variation.For example, by for Gaussian pulse analysis shows, Self-phase modulation will lead to pulse front edge spectrum red shift, rear blue along spectrum
It moves, also has similar result to the analysis of other shapes pulse.In addition, it is opposite in the anomalous dispersion region of group velocity dispersion (GVD),
High frequency (blue shift) component motion speed of pulse is higher than low frequency (red shift) component, and caused by Self-phase modulation (SPM) effect
Pulse front edge spectrum red shift make again pulse front edge movement velocity slow down with pulse back edge due to compose blue shift and accelerate movement velocity, into
And making pulse narrowing, the trend that just pulse with group velocity dispersion in the anomalous dispersion region broadens is corresponding.Therefore, when this two
When kind effect quantitatively reaches balance, light pulse will remain unchanged and become light orphan particle, i.e. soliton.Thus, light
The formation mechenism of orphan be in optical fiber group velocity dispersion and self phase modulation in the accurate balance of the anomalous dispersion region.
1986, the nonlinear optics effect of Mitschke and the soliton self-frequency sh (SSFS) in Mollenauer discovery optical fiber
It answers [1]: when Ultrashort Soliton is propagated in abnormal dispersion fiber, continuous wavelength can be undergone to shift to long wavelength.Certainly by orphan
Frequency shifting techniques can the tunable soliton of generation wavelength, the soliton have the following characteristics that ultrashort pulse width (tens fly
Second arrive subpicosecond magnitude), the tunability of excellent pulse quality and broad band wavelength.It is aobvious that these features become multi-photon
The highly desirable light source selection of micro- imaging technique (MPM).
Multi-photon micro-imaging is a kind of nonlinear optics imaging technique, is imaged especially suitable for living body deep tissues.It is more
Photon micro-imaging technique is widely used in biology, physiology and medical research with different mode.
Multi-photon signal is limited by soliton energy in the brain, so that the mistake that multi-photon signal is propagated in brain tissue
Cheng Zhong, absorption and scattering exponentially attenuation trend with brain tissue.Conventionally, as multi-photon micro imaging system
The soliton energy of generation is lower, causes existing multi-photon micro imaging system that can only study the tissue of brain shallow-layer, therefore,
The tissue of brain deep layer can not be further studied, to limit further exploration of the mankind to brain deep layer.
Summary of the invention
The main purpose of the present invention is to provide a kind of circular polarization orphan generation device and multi-photon micro imaging system, purports
In the lower technical problem of the soliton energy for solving to generate in the prior art.
In order to solve the above technical problem, the present invention provides technical solution are as follows:
A kind of circular polarization orphan generation device, including pump laser, the first quarter-wave being located in same optical path
Piece, the first condenser lens and optical fiber, wherein the line polarisation that the pump laser generates is after the first quarter-wave plate
It is changed into rotatory polarization, rotatory polarization is coupled in the optical fiber after the condenser lens, and rotatory polarization turns after the optical fiber
Become circular polarization orphan.
Wherein, the circular polarization orphan generation device further includes the first collimation lens and long wave pass filter, wherein circle is inclined
Vibration orphan scatters after the collimation lens, and the circular polarization orphan after scattering carried out by the long wave pass filter
Filter.
Wherein, the optical fiber is rodlike photonic crystal fiber.
A kind of multi-photon micro imaging system, including the second quarter-wave plate, f-theta lens, dichroscope, object
Mirror, photomultiplier tube and the described in any item circular polarization orphan generation devices of claim 1-3；Wherein, the circular polarization is lonely
The circular polarization orphan that sub- generation device generates is changed into linear polarization orphan after second quarter-wave plate, and linear polarization is lonely
Son is coupled in object lens after the f-theta lens and the dichroscope, and is focused on object to be detected by object lens
Signal is generated, signal successively passes through the object lens and the dichroscope after scattering, and the dichroscope couples signal
It is imaged into the photomultiplier tube, and through the photomultiplier tube.
Wherein, the multi-photon micro imaging system further includes the first reflecting mirror, and first reflecting mirror is located at described the
Between two quarter-wave plates and the f-theta lens.
Wherein, the multi-photon micro imaging system further includes tube lens, and it is poly- that the tube lens are located at the flat field
Between focus lens and the dichroscope.
Wherein, the multi-photon micro imaging system further includes the second reflecting mirror, and second reflecting mirror is located at the mirror
Between cylinder lens and the dichroscope.
Above-mentioned circular polarization orphan generation device and multi-photon micro imaging system make line by the first quarter-wave plate
Polarisation becomes rotatory polarization, then rotatory polarization is become to circular polarization orphan after optical fiber.Test proves that under equal conditions,
The energy of circular polarization orphan is 1.56 times of linear polarization orphan's energy, and multi-photon signal is transmitted more in the brain
Far, so that the mankind be enable further to explore the tissue of brain deep layer, and then the veil of brain mystery is unlocked.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those skilled in the art without creative efforts, can also basis
These attached drawings obtain other attached drawings.
Fig. 1 is the schematic diagram of circular polarization orphan generation device according to an embodiment of the invention.
Fig. 2 is circular polarization orphan and linear polarization orphan according to an embodiment of the invention by long wave pass filter
Energy comparison diagram.
Fig. 3 (a) is that line polarisation according to an embodiment of the invention is pumped by the normalization of the first quarter-wave plate
The relational graph of Pu power and polarizing film rotation angle.
Fig. 3 (b) be rotatory polarization according to an embodiment of the invention by the normalization pump power of collimation lens and
The relational graph of polarizing film rotation angle.
Fig. 4 is the schematic diagram of multi-photon micro imaging system according to an embodiment of the invention.
10, multi-photon micro imaging system；1, circular polarization orphan generation device；11, pump laser；12, the one or four point
One of wave plate；13, the first condenser lens；14, optical fiber；15, the first collimation lens；16, long wave pass filter；The two or four 2 ,/
One wave plate；3, f-theta lens；31, scanning mirror；32, scanning lens；4, dichroscope；5, object lens；6, photomultiplier tube；7,
First reflecting mirror；8, tube lens；9, the second reflecting mirror.
Specific embodiment
In order to make the invention's purpose, features and advantages of the invention more obvious and easy to understand, below in conjunction with the present invention
Attached drawing in embodiment, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described reality
Applying example is only a part of the embodiment of the present invention, and not all embodiments.Based on the embodiments of the present invention, those skilled in the art
Member's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
Fig. 1 is the schematic diagram of circular polarization orphan generation device according to an embodiment of the invention.
It can be seen from the figure that circular polarization orphan generation device 1 can have the pumping laser in same optical path
Device 11, the first quarter-wave plate 12, the first condenser lens 13 and optical fiber 14, wherein the line that pump laser 11 generates is inclined
Light is changed into rotatory polarization after the first quarter-wave plate 12, and rotatory polarization is coupled in optical fiber 14 after condenser lens, circle
Polarisation is changed into circular polarization orphan after optical fiber 14.
In the present embodiment, by the first quarter-wave plate 12, line polarisation is made to become rotatory polarization, then rotatory polarization is passed through
Become circular polarization orphan after optical fiber 14.Test proves that under equal conditions, the energy of circular polarization orphan is linear polarization orphan
1.56 times of energy enable multi-photon signal to transmit in the brain farther, so that the mankind be enable further to explore greatly
The tissue of brain deep layer, and then unlock the veil of brain mystery.
Energy below by way of theoretical proof circular polarization orphan is 1.56 times of linear polarization orphan's energy, and linear polarization orphan exists
Propagation formula in optical fiber 14 are as follows:
Wherein, i indicates imaginary unit,Indicating that differential sign, z indicate transmission range, Ax indicates linear polarization pulse envelope,
β2Indicate group velocity dispersion, T indicates the time, and γ indicates nonlinear factor.
Propagation formula of the circular polarization orphan in optical fiber 14 are as follows:
Wherein, A+ indicates right-hand circular polarization orphan envelope, and formula (2) rushes that equally applicable (A+ is changed to left-handed inclined orphan
A-)。
One new nonlinear coefficient γ '=2/3 γ can define by formula (1) and formula (2), so that the two is consistent.It is public
Formula (2) can be exchanged into the energy of circular polarization orphan, and formula is as follows:
Wherein, En+Indicate the energy of circular polarization orphan, EnxIndicate the energy of linear polarization orphan.
By formula (3) it is found that the energy of circular polarization orphan is 1.5 times of linear polarization orphan's energy.
Below by way of experiments have shown that the energy of circular polarization orphan is 1.56 times of linear polarization orphan's energy, in the present embodiment
In, testing pump laser 11 used is (FLCPA-02CSZU, Calmar), and the line that output laser is wavelength 1550nm is inclined
Light, pulse width 500fs, repetition rate 1MHz.As shown in Figure 2, under identical condition, circular polarization orphan and line are inclined
Energy ratio of the orphan after long wave pass filter 16 of shaking is 1.56 or so, is matched with theoretical value 1.5.
Below by way of experiments have shown that the line polarisation that pump laser 11 generates changes after the first quarter-wave plate 12
For rotatory polarization.Polarizing film and power meter, rotatory polarization piece are set behind the first quarter-wave plate 12, and measured by power
Measure the postrotational power of polarizing film.In theoretical situation, the power of each angle of rotatory polarization is equal；But in actual conditions
Under, there is a certain error for the power meeting of each angle of rotatory polarization.As shown in Fig. 3 (a), abscissa is angle, and ordinate is
Normalized power, wherein normalized power indicate the power of each angle divided by maximum power be exactly the angle normalization
Power is 23.5mw in the power that 60 degree measure, wherein maximum function for example, measuring ten performance numbers in 0-360 degree now
Rate is 24.5mw, then 60 degree of normalized power is 23.5/24.5.In theoretical situation, the extinction ratio of rotatory polarization is 1, still,
In practical situations, the extinction ratio of rotatory polarization is close to 1, wherein extinction ratio indicates minimum power of the rotatory polarization under different angle
The ratio between with maximum power.Finally, the Extinction ratio pump=1.06 measured is tested, it follows that pump laser 11 generated
Line polarisation is changed into rotatory polarization after the first quarter-wave plate 12.
Below by way of experiments have shown that rotatory polarization becomes circular polarization orphan after optical fiber 14, in the present embodiment, first
Polarizing film and power meter, rotatory polarization piece are set behind collimation lens 15, and the postrotational function of polarizing film is measured by power meter
Rate.As shown in Fig. 3 (b), abscissa is angle, and ordinate is normalized power.Finally, the Extinction ratio pump measured is tested
=1.03, it follows that rotatory polarization becomes circular polarization orphan after optical fiber 14.
In the illustrated embodiment, circular polarization orphan generation device 1 further includes the first collimation lens 15 and long wave pass filter
16, wherein circular polarization orphan scatters after collimation lens, and the circular polarization orphan after scattering passes through long wave pass filter 16
It is filtered.It being capable of circular polarization orphan other than filter specific wavelengths by long wave pass filter 16.In the present embodiment, long wave
Pass filter 16 allow by circular polarization orphan wavelength be 1617nm.
In the present embodiment, optical fiber 14 is rodlike photonic crystal fiber.It will be seen that in an alternate embodiment of the invention, optical fiber
14 may be high-order mode fiber, large mode field optical fiber or hollow-core fiber.
Fig. 4 is the schematic diagram of multi-photon micro imaging system according to an embodiment of the invention.
It can be seen from the figure that the multi-photon micro imaging system 10 can have the second quarter-wave plate 2, flat field gathers
Circular polarization orphan's generation device of any one of focus lens 3, dichroscope 4, object lens 5, photomultiplier tube 6 and claim 1-3
1；Wherein, the circular polarization orphan that circular polarization orphan generation device 1 generates is changed into linear polarization after the second quarter-wave plate 2
Orphan, linear polarization orphan are coupled in object lens 5 after f-theta lens 3 and dichroscope 4, and are focused on by object lens 5
Signal is generated on object to be detected, signal successively passes through object lens 5 and dichroscope 4 after scattering, and dichroscope 4 couples signal
It is imaged into photomultiplier tube 6, and through photomultiplier tube 6.
In the illustrated embodiment, multi-photon micro imaging system 10 further includes the first reflecting mirror 7, and the first reflecting mirror 7 is located at
Between second quarter-wave plate 2 and f-theta lens 3.
In the illustrated embodiment, multi-photon micro imaging system 10 further includes tube lens 8, and tube lens 8 are located at flat field
Between condenser lens 3 and dichroscope 4.
In the illustrated embodiment, multi-photon micro imaging system 10 further includes the second reflecting mirror 9, and the second reflecting mirror 9 is located at
Between tube lens 8 and dichroscope 4.Dichroscope 4 is transmissive to the soliton of long wavelength, the long soliton of reflecting short.
In the present embodiment, dichroscope 4 is transmissive to the soliton of 1617nm wavelength, reflects the soliton of 716nm wavelength.
In the present embodiment, f-theta lens 3 include X, Y axis scanning mirror 31 and scanning lens 32.
The course of work:
The line polarisation that pump laser 11 generates becomes rotatory polarization after one or four/wave plate, and rotatory polarization is through over-focusing
It is coupled in rodlike photonic crystal fiber 14 after lens, rotatory polarization becomes circular polarization orphan after rodlike photonic crystal fiber 14
Son, circular polarization orphan are spread after collimation lens, and the circular polarization orphan after diffusion carries out by long wave pass filter 16
Filtering, filtered circular polarization orphan become linear polarization orphan by the second quarter-wave plate 2, and linear polarization orphan passes through first
Reflecting mirror 7 reflects, and the linear polarization orphan after reflection is spread after f-theta lens 3 and tube lens 8, diffusion
Linear polarization orphan afterwards is reflected by the second reflecting mirror 9, and the linear polarization orphan after transmitting is coupled to object by dichroscope 4
In mirror 5, linear polarization orphan focuses on the fluorescent dye of object to be checked by object lens 5, and fluorescent dye is made to generate non-linear effect
(fluorescent molecule absorbs three photon leaps to excitation state, and excitation state becomes ground state and emits a photon) is answered, to generate glimmering
Optical signal, fluorescence signal successively pass through object lens 5 and dichroscope 4 after scattering, and fluorescence signal is coupled to light by dichroscope 4
In electric multiplier tube 6, finally, it is imaged by photomultiplier tube 6.
The above are retouch to a kind of circular polarization orphan generation device provided by the present invention and multi-photon micro imaging system
It states, for those skilled in the art, thought according to an embodiment of the present invention has on specific embodiment and application range
Change place, to sum up, the contents of this specification are not to be construed as limiting the invention.
Claims (7)
1. a kind of circular polarization orphan generation device, which is characterized in that including be located at same optical path on pump laser, the one or four
/ mono- wave plate, the first condenser lens and optical fiber, wherein the line polarisation that the pump laser generates by the one or four/
It is changed into rotatory polarization after one wave plate, rotatory polarization is coupled in the optical fiber after the condenser lens, described in rotatory polarization process
It is changed into circular polarization orphan after optical fiber.
2. circular polarization orphan generation device according to claim 1, which is characterized in that the circular polarization orphan generation device
It further include the first collimation lens and long wave pass filter, wherein circular polarization orphan scatters after the collimation lens, dissipates
Circular polarization orphan after penetrating is filtered by the long wave pass filter.
3. circular polarization orphan generation device according to claim 1, which is characterized in that the optical fiber is rodlike photonic crystal
Optical fiber.
4. a kind of multi-photon micro imaging system, which is characterized in that including the second quarter-wave plate, f-theta lens, two
To Look mirror, object lens, photomultiplier tube and the described in any item circular polarization orphan generation devices of claim 1-3；Wherein, described
The circular polarization orphan that circular polarization orphan's generation device generates is changed into linear polarization orphan after second quarter-wave plate,
Linear polarization orphan is coupled in object lens after the f-theta lens and dichroscope, and is focused on by object lens to be detected
Generate signal on object, signal scatter after successively by the object lens and the dichroscope, the dichroscope is by signal
It is coupled in the photomultiplier tube, and is imaged by the photomultiplier tube.
5. multi-photon micro imaging system according to claim 4, which is characterized in that the multi-photon micro imaging system
Further include the first reflecting mirror, first reflecting mirror be located at second quarter-wave plate and the f-theta lens it
Between.
6. multi-photon micro imaging system according to claim 4, which is characterized in that the multi-photon micro imaging system
It further include tube lens, the tube lens are between the f-theta lens and the dichroscope.
7. multi-photon micro imaging system according to claim 6, which is characterized in that the multi-photon micro imaging system
It further include the second reflecting mirror, second reflecting mirror is between the tube lens and the dichroscope.
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| CN201910552925.XA CN110221445A (en) | 2019-06-25 | 2019-06-25 | Circular polarization orphan generation device and multi-photon micro imaging system |
| PCT/CN2019/123620 WO2020258734A1 (en) | 2019-06-25 | 2019-12-06 | Circularly polarized soliton generating device and multiphoton microscopic imaging system |
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| WO2020258734A1 (en) * | 2019-06-25 | 2020-12-30 | 深圳大学 | Circularly polarized soliton generating device and multiphoton microscopic imaging system |
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| CN112113940A (en) * | 2020-08-28 | 2020-12-22 | 深圳大学 | Fluorescence imaging device and fluorescence imaging method |
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