CN110215609A - A kind of pulsed magnetic field bracket and electromagnetic stimulation device for experimental animal - Google Patents
A kind of pulsed magnetic field bracket and electromagnetic stimulation device for experimental animal Download PDFInfo
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- CN110215609A CN110215609A CN201910575894.XA CN201910575894A CN110215609A CN 110215609 A CN110215609 A CN 110215609A CN 201910575894 A CN201910575894 A CN 201910575894A CN 110215609 A CN110215609 A CN 110215609A
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- 238000004891 communication Methods 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
Abstract
The present invention provides a kind of pulsed magnetic field bracket and electromagnetic stimulation device for experimental animal, electromagnetic stimulation device includes power supply, pulse current generating unit, driver, microprocessor and pulsed magnetic field bracket；Pulsed magnetic field bracket includes loop construction, support construction and stop sleeve；The accommodating chamber that can place experimental animal is equipped in stop sleeve, loop construction includes coil base and can be to the coil on the head of covering experimental animal, coil is affixed with coil base, coil and coil base are slidably arranged in inside accommodating chamber, stop sleeve is equipped with first sliding groove, first sliding groove is axially disposed on stop sleeve, and the retaining mechanism that can be positioned to coil base is equipped in first sliding groove.A kind of pulsed magnetic field bracket and electromagnetic stimulation device for experimental animal of the present invention, solves the vacancy of the electromagnetic stimulation device applied to zoopery, and brings the technical problem of many inconvenience in experimentation to experimenter.
Description
Technical field
The invention belongs to zoopery fields, more particularly, to a kind of pulsed magnetic field bracket and electromagnetism for experimental animal
Stimulating apparatus.
Background technique
The mankind had found the fact that organism electrification before more than 200 years, and L. Galvanic is in 18th century by frog flesh and different gold
The circuit joint for belonging to constituted shrinks phenomenon, proposes " animal electricity " viewpoint.In early 20th century, W. Ai Yintehuofen is used
Sensitive string galvanometer directly measures faint bioelectricity.Michael Faraday was in discovery electromagnetic induction in 1832
Whether law can stimulate nerve to provide theoretical basis to probe into changing magnetic field generation induced current.
Transcranial magnetic stimulation (TMS) technology be it is a kind of using pulsed magnetic field action in central nervous system (mainly brain),
The film potential for changing cortical neurogenic cell, is allowed to generate induced current, intracerebral metabolism and neural electrical activity is influenced, so as to cause one
The Neural stem cell technology of serial biochemical reactions.Cerebral nerve is stimulated using Neural stem cell in Barker in 1985 et al.,
The motor center that successfully have stimulated people has measured motor cortex Evoked ptential (MEPs) with myoelectricity, has indicated from this through cranium magnetic
Stimulation (TMS) enters the arena of history.But the effect of transcranial magnetic stimulation (TMS) technology in clinical application with have it is without side-effects
Not yet thoroughly, being verified by way of zoopery to it will be effective method for research.
The electromagnetic stimulation device proprietary currently used for experimental animal uses almost without ready-made device, to experimenter with
It is many inconvenient to come.
Summary of the invention
In view of this, the present invention is directed to propose a kind of pulsed magnetic field bracket and electromagnetic stimulation device for experimental animal,
It solves the vacancy of the electromagnetic stimulation device applied to zoopery, and brings many inconvenience to experimenter in experimentation
The technical issues of.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows:
A kind of pulsed magnetic field bracket, including loop construction, support construction and stop sleeve；
Be equipped with the accommodating chamber that can place experimental animal in the stop sleeve, the loop construction include coil base and
Can be to the coil on the head of covering experimental animal, the coil and the coil base are affixed, the coil and coil base
It is slidably arranged in inside the accommodating chamber, the stop sleeve is equipped with first sliding groove, and the first sliding groove is axially disposed within institute
It states on stop sleeve, the retaining mechanism that can be positioned to coil base is equipped in the first sliding groove；
The support construction and the stop sleeve are affixed.
Further, the loop construction further include can to covering experimental animal head coil liner, the line
It is consistent with the coil inner wall shape to enclose liner outer wall, the coil liner is arranged in the coil inside, the coil liner
Positioning plate is equipped on the outside of the end of one end.
Further, the coil base is equipped with circular cone inner groovy, and the coil is equipped with can be with the circular cone indent
First conic convex of slot cooperation, the coil liner is equipped with far from the end of the positioning plate can be convex with first circular cone
Play the second conic convex of cooperation.
Further, the circular cone inner groovy is equipped with the first venthole, and first conic convex is equipped with the second venthole,
Second conic convex is equipped with third venthole, between first venthole, the second venthole and third venthole mutually
Connection.
Further, the support construction includes the first support plate and the second support plate, first support plate and second
Support plate is symmetricly set on the stop sleeve rear ends, and first support plate is equipped with opening, and the opening area is greater than
Or it is equal to coil base radial cross-sectional area.
Further, second support plate is equipped with dew uropore.
Further, first support plate is equipped with the first semienclosed slot, and the stop sleeve is equipped with second sliding slot, described
Second support plate is equipped with the second semienclosed slot, mutually interconnects between first semienclosed slot, second sliding slot and the second semienclosed slot
Logical, first semienclosed slot and the open communication, second semienclosed slot are connected to the dew uropore, and described the first half
The notch of enclosed slot, second sliding slot and the second semienclosed slot is greater than or equal to experimental animal tail diameter.
Further, the retaining mechanism includes holding screw and knurled nut, and the holding screw setting is sliding first
In slot, the holding screw is connect with the coil base outer wall, and the knurled nut is threadedly coupled with the holding screw, institute
Knurled nut is stated to be arranged outside the coil base.
Further, the knurled nut is high head hand nutting.
Compared with the existing technology, a kind of pulsed magnetic field bracket of the present invention has the advantage that
First support plate and the second support plate play cross-brace tub, are conducive to stablizing for stop sleeve and place, when interior
Portion animal is not easy to topple over displacement when restless；It is conducive to control animal fixed space size by first sliding groove, is suitable for different building shape
The animal of size；By the first semienclosed slot, second sliding slot and the second semienclosed slot convenient for affecting animal tail portion, animal is drawn
To stop sleeve, the hand of animal and experimenter are kept apart in distraction procedure, to experiment people during struggling to prevent animal
Member damages；First semienclosed slot, second sliding slot and the second semienclosed slot can play the role of drawing coil connecting line, in order to avoid
Experimental animal destroys connecting portion, impacts to circuit operation；First semienclosed slot, second sliding slot and the second semienclosed slot are also
Have the function of that animal excrements are discharged, in order to avoid polluting device；
It is simple in terms of the fixed function operations of this bracket, the fixation of experimental animal, one man operation are completed by retaining mechanism
Also without a doubt, valuable time is saved for experimenter, improves conventional efficient.It also carries out on the original basis simultaneously
The innovation of coil, in order to cover the head of experimental animal completely preferably by pulsed magnetic field action in the head of experimental animal
It covers in coil, makes pulsed magnetic field is as much as possible to act on animal head, and reduce the loss during it, while also avoiding
Pulse electromagnetic is improved using high-power circuit and increases the loss of electric energy, and avoids damage of the high current to animal, further
Ensure safety.
A kind of electromagnetic stimulation device for experimental animal, including power supply, pulse current generating unit, driver, Wei Chu
Manage device and the pulsed magnetic field bracket；
The coil of the pulsed magnetic field bracket is connect by two conducting wires with the pulse current generating unit, micro- place
Reason device is connect by the driver with the pulse current generating unit, the pulse current generating unit, driver, Wei Chu
Reason device is connect with the power supply.
Compared with the existing technology, a kind of electromagnetic stimulation device for experimental animal of the present invention has following excellent
Gesture:
The set electromagnetic stimulation device technical advantage achieved and effect include that above-mentioned pulsed magnetic field bracket is reached as a result,
Technical advantage and effect, no longer repeated herein.In addition, a kind of electromagnetic stimulation for experimental animal of the present invention
Pulsed magnetic field bracket and pulse electromagnetic generator perfect combination are had the pulse that will be generated by device, entire electromagnetic stimulation device
Magnetic fields are in the effect of laboratory animal head.Electromagnetic stimulation device overall structure is simple, so the use of package unit also subtracts
The cost of experiment is lacked, while its is easy to operate, service efficiency is high, and stability is high and high safety, many aspects all meet reality
The requirement tested.
Detailed description of the invention
The attached drawing for constituting a part of the invention is used to provide further understanding of the present invention, schematic reality of the invention
It applies example and its explanation is used to explain the present invention, do not constitute improper limitations of the present invention.In the accompanying drawings:
Fig. 1 is a kind of pulsed magnetic field bracket the schematic diagram of the section structure described in the embodiment of the present invention；
Fig. 2 is a kind of pulsed magnetic field supporting structure schematic diagram described in the embodiment of the present invention；
Fig. 3 is a kind of another angled arrangement schematic diagram of pulsed magnetic field bracket described in the embodiment of the present invention；
Fig. 4 is a kind of another angular profile structural schematic diagram of pulsed magnetic field bracket described in the embodiment of the present invention；
Fig. 5 is a kind of pulsed magnetic field bracket partial structural diagram described in the embodiment of the present invention；
Fig. 6 is coil base and locking mechanism structure schematic diagram described in the embodiment of the present invention；
Fig. 7 is coil and coil inner lining structure schematic diagram described in the embodiment of the present invention；
Fig. 8 is coil inner lining structure schematic diagram described in the embodiment of the present invention；
Fig. 9 is loop construction schematic diagram described in the embodiment of the present invention；
Figure 10 is a kind of electromagnetic stimulation device schematic diagram for experimental animal described in the embodiment of the present invention.
Description of symbols:
The first support plate of 1-；2- stop sleeve；The second support plate of 3-；4- first sliding groove；41- second sliding slot；5- clamp screw
Nail；6- knurled nut；7- coil base；The first venthole of 8-；The first semienclosed slot of 9-；10- accommodating chamber；11- reveals uropore；12-
Coil liner；13- coil；14- circular cone inner groovy；The second venthole of 15-；16- third venthole；17- power supply；18- pulse electricity
Flow generating unit；19- driver；20- microprocessor.
Specific embodiment
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", "upper", "lower",
The orientation or positional relationship of the instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside" is
It is based on the orientation or positional relationship shown in the drawings, is merely for convenience of description of the present invention and simplification of the description, rather than instruction or dark
Show that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as pair
Limitation of the invention.In addition, term " first ", " second " etc. are used for description purposes only, it is not understood to indicate or imply phase
To importance or implicitly indicate the quantity of indicated technical characteristic.The feature for defining " first ", " second " etc. as a result, can
To explicitly or implicitly include one or more of the features.In the description of the present invention, unless otherwise indicated, " multiple "
It is meant that two or more.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood by concrete condition
Concrete meaning in the present invention.
The present invention will be described in detail below with reference to the accompanying drawings and embodiments.
A kind of pulsed magnetic field bracket, as shown in Figure 1, including loop construction, support construction and stop sleeve 2；
The present invention can be for mouse, rabbit, sheep, ox etc. for the type of animal, the preferred meiofauna of experimental animal, such as mouse,
Rabbit, in order to the operation on implementing.
The accommodating chamber 10 that can place experimental animal is equipped in stop sleeve 2, loop construction includes coil base 7 and can
To the coil 13 on the head of covering experimental animal, coil 13 and coil base 7 are affixed, coil 13 and the sliding setting of coil base 7
Inside accommodating chamber 10, stop sleeve 2 is equipped with first sliding groove 4, and first sliding groove 4 is axially disposed on stop sleeve 2, and first is sliding
The retaining mechanism that can be positioned to coil base 7 is equipped in slot 4；
Support construction and stop sleeve 2 are affixed, and support construction includes the first support plate 1 and the second support plate 3, the first support
Plate 1 and the second support plate 3 are symmetricly set on 2 rear ends of stop sleeve, the first support plate 1, the second support plate 3 in the present embodiment
And stop sleeve 2 is integrally formed, the first support plate 1 is equipped with opening, and opening area is greater than or equal to 7 radial section of coil base
Area.Second support plate 3 is equipped with dew uropore 11.
Loop construction further includes can be to the coil liner 12 on the head of covering experimental animal, 12 outer wall of coil liner and line
It is consistent to enclose 13 inner wall shapes, coil liner 12 is arranged inside coil 13, and coil liner 12 protects coil 13 not dynamic by experiment
The effect that object is gnawed, and then prevent experimental animal coil from gnawing and cause coil 13 short-circuit, it is set on the outside of 12 one end end of coil liner
There is positioning plate, coil liner 12 is embedded in 13 inside of coil by positioning plate.
Coil base 7 is equipped with circular cone inner groovy 14, and coil 13 is equipped with the first circle that can cooperate with circular cone inner groovy 14
Cone protrusion, the end of the remotely located plate of coil liner 12 are equipped with the second conic convex that can cooperate with the first conic convex, line
Circle 13 is affixed by carrying out on the inside of the first conic convex and circular cone inner groovy 14, in the present embodiment in the first conic convex and circular cone
Groove 14 is connected by way of gluing.
Circular cone inner groovy 14 is equipped with the first venthole 8, and the first conic convex is equipped with the second venthole 15, the second conic convex
Equipped with third venthole 16, it is interconnected between the first venthole 8, the second venthole 15 and third venthole 16, and then can
Guarantee that the breathing of experimental animal is unimpeded, in implementation process, 8 common spindle of the second venthole 15 and the first venthole, third ventilation
Hole 16 and the second venthole 15,8 common spindle of the first venthole.
First support plate 1 is equipped with the first semienclosed slot 9, and stop sleeve 2 is equipped with second sliding slot 41, and the second support plate 3 is equipped with
Second semienclosed slot is interconnected between the first semienclosed slot 9, second sliding slot 41 and the second semienclosed slot, the first semienclosed slot 9
With open communication, the second semienclosed slot is connected to dew uropore 11, the first semienclosed slot 9, second sliding slot 41 and the second semienclosed slot
Notch be greater than or equal to experimental animal tail diameter.
Retaining mechanism includes holding screw 5 and knurled nut 6, and holding screw 5 is arranged in first sliding groove 4, holding screw 5
It is connect with 7 outer wall of coil base, knurled nut 6 is threadedly coupled with holding screw 5, and knurled nut 6 is arranged outside coil base 7
Portion, in the present embodiment, knurled nut 6 is high head hand nutting, and knurled nut 6 can be driven by holding screw 5 in implementation process
Coil base 7 is moved forward and backward transformation fixed space size in accommodating chamber 10, and then can be suitable for different building shape experimental animal
Fixation.
A kind of electromagnetic stimulation device for experimental animal, including power supply 17, pulse current generating unit 18, driver
19, microprocessor 20 and pulsed magnetic field bracket；
In the present embodiment, driver 19 is the type of drivers such as L298N, and microprocessor 20 is STM32F103ZET6；
The coil 13 of pulsed magnetic field bracket is connect by two conducting wires with pulse current generating unit 18, and microprocessor 20 is logical
Device 19 of overdriving is connect with pulse current generating unit 18, pulse current generating unit 18, driver 19, microprocessor 20 with
Power supply 17 connects, and in implementation process, 13 two conducting wires of coil determine magnetic direction according to electric magnetisation right-hand rule principle, guarantees magnetic
Field direction is directed toward animal tail portion mode by laboratory animal head and connect with pulse current generating unit 18, and microprocessor 20 is by signal
Pulse current generating unit 18 is transferred to after the amplification of driver 19 and generates corresponding pulses electric current, then is generated accordingly through coil 13
Pulsed magnetic field.
The working method of this example
Embodiment 1
Firstly, holding experimental animal tail portion successively passes through the first semienclosed slot 9, second sliding slot 41, the second semienclosed slot, into
And experimental animal is pulled in accommodating chamber 10, then the good coil liner 12 of overall package, coil 13 and coil base 7 are entangled into reality
The position of coil base 7 is adjusted on the head for testing animal, is determined by holding screw 5 and knurled nut 6 coil base 7
Position, and then laboratory animal head is fixed in accommodating chamber 10, finally will turn on power supply 17 makes to generate magnetic field in coil 13.
Embodiment 2
Multiple coils 13 are in parallel, and multiple coils 13 are connect with pulse current generating unit 18 simultaneously.
Embodiment 3
Multiple coils 13 are connected, and multiple coils 13 are connect with pulse current generating unit 18 simultaneously.
Embodiment 4
It is one group of unit by single pulse electric current generating unit 18 and single coil 13, it is in parallel between multiple groups unit, and
The pulse current generating unit 18 of every group of unit is connect with driver 19 and power supply 20.
Embodiment 5
It is one group of unit by single pulse electric current generating unit 18 and single coil 13, connects between multiple groups unit, and
The pulse current generating unit 18 of every group of unit is connect with driver 19 and power supply 20.
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of pulsed magnetic field bracket, it is characterised in that: including loop construction, support construction and stop sleeve (2)；
The accommodating chamber (10) that can place experimental animal is equipped in the stop sleeve (2), the loop construction includes coil base
Seat (7) and can to covering experimental animal head coil (13), the coil (13) and the coil base (7) are affixed,
It is internal that the coil (13) and coil base (7) are slidably arranged in the accommodating chamber (10), and the stop sleeve (2) is equipped with the
One sliding slot (4), the first sliding groove (4) are axially disposed on the stop sleeve (2), and energy is equipped in the first sliding groove (4)
Enough retaining mechanisms that coil base (7) are positioned；
The support construction and the stop sleeve (2) are affixed.
2. a kind of pulsed magnetic field bracket according to claim 1, it is characterised in that: the loop construction further includes can be right
Cover the coil liner (12) on the head of experimental animal, coil liner (12) outer wall and the coil (13) inner wall shape one
It causes, coil liner (12) setting is internal in the coil (13), and it is fixed to be equipped on the outside of coil liner (12) one end end
Position plate.
3. a kind of pulsed magnetic field bracket according to claim 2, it is characterised in that: the coil base (7) is equipped with circle
It bores inner groovy (14), the coil (13) is equipped with the first conic convex that can cooperate with the circular cone inner groovy (14), described
Coil liner (12) is equipped with the second conic convex that can cooperate with first conic convex far from the end of the positioning plate.
4. a kind of pulsed magnetic field bracket according to claim 3, it is characterised in that: the circular cone inner groovy (14) is equipped with the
One venthole (8), first conic convex are equipped with the second venthole (15), and second conic convex is equipped with third venthole
(16), it is interconnected between first venthole (8), the second venthole (15) and third venthole (16).
5. a kind of pulsed magnetic field bracket according to claim 1-4, it is characterised in that: the support construction includes
First support plate (1) and the second support plate (3), first support plate (1) and the second support plate (3) are symmetricly set on the branch
Support set cylinder (2) rear ends, first support plate (1) are equipped with opening, and the opening area is greater than or equal to coil base (7)
Radial cross-sectional area.
6. a kind of pulsed magnetic field bracket according to claim 5, it is characterised in that: second support plate (3) is equipped with dew
Uropore (11).
7. a kind of pulsed magnetic field bracket according to claim 6, it is characterised in that: first support plate (1) is equipped with the
One semienclosed slot (9), the stop sleeve (2) are equipped with second sliding slot (41), and it is semiclosed that second support plate (3) is equipped with second
Slot is interconnected between first semienclosed slot (9), second sliding slot (41) and the second semienclosed slot, and described first is semiclosed
Slot (9) and the open communication, second semienclosed slot are connected to the dew uropore (11), first semienclosed slot (9),
The notch of second sliding slot (41) and the second semienclosed slot is greater than or equal to experimental animal tail diameter.
8. a kind of described in any item pulsed magnetic field brackets of according to claim 6 or 7, it is characterised in that: the retaining mechanism packet
Holding screw (5) and knurled nut (6) are included, holding screw (5) setting is in first sliding groove (4), the holding screw (5)
It is connect with the coil base (7) outer wall, the knurled nut (6) is threadedly coupled with the holding screw (5), the annular knurl spiral shell
Female (6) setting is external in the coil base (7).
9. a kind of pulsed magnetic field bracket according to claim 8, it is characterised in that: the knurled nut (6) is high head hand
Nutting.
10. a kind of electromagnetic stimulation device for experimental animal, it is characterised in that: occur including power supply (17), pulse current single
First (18), driver (19), microprocessor (20) and claim 1-4 and/or the described in any item pulsed magnetics of claim 6-7
Field bracket；
The coil (13) of the pulsed magnetic field bracket is connect by two conducting wires with the pulse current generating unit (18), described
Microprocessor (20) is connect by the driver (19) with the pulse current generating unit (18), and the pulse current occurs
Unit (18), driver (19), microprocessor (20) are connect with the power supply (17).
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| CN201910575894.XA CN110215609A (en) | 2019-06-28 | 2019-06-28 | A kind of pulsed magnetic field bracket and electromagnetic stimulation device for experimental animal |
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| CN201910575894.XA CN110215609A (en) | 2019-06-28 | 2019-06-28 | A kind of pulsed magnetic field bracket and electromagnetic stimulation device for experimental animal |
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