CN110215179B - Medicine releasing device of capsule endoscope and capsule endoscope - Google Patents
Medicine releasing device of capsule endoscope and capsule endoscope Download PDFInfo
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- CN110215179B CN110215179B CN201910538007.1A CN201910538007A CN110215179B CN 110215179 B CN110215179 B CN 110215179B CN 201910538007 A CN201910538007 A CN 201910538007A CN 110215179 B CN110215179 B CN 110215179B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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Abstract
The invention discloses a medicine releasing device of a capsule endoscope and the capsule endoscope, the medicine releasing device comprises: the drug releasing device includes a light emitting portion for emitting light, and a drug releasing portion configured to release a drug stored in the drug releasing portion under irradiation of the light emitted by the light emitting portion. The capsule endoscope can realize accurate release of the medicine in a human body and meet the use requirement of the capsule endoscope.
Description
Technical Field
The invention relates to the technical field of display, in particular to a medicine release device of a capsule endoscope and the capsule endoscope.
Background
The capsule endoscope is a medical appliance, and is placed in the digestive tract of a human body when in use, and the built-in camera shooting part is used for shooting and obtaining images so as to fulfill the aim of seeing the health condition of the intestines, stomach and esophagus of the human body.
With the development of technology, capsule endoscopes are required to have a function of precisely releasing drugs in the human body.
Disclosure of Invention
The embodiment of the invention provides a medicine release device of a capsule endoscope, which can realize accurate medicine release in a human body and meet the use requirement of the capsule endoscope. The technical scheme is as follows:
in one aspect, an embodiment of the present invention provides a drug release device of a capsule endoscope, including: the drug releasing device includes a light emitting portion for emitting light, and a drug releasing portion configured to release a drug stored in the drug releasing portion under irradiation of the light emitted by the light emitting portion.
In one implementation manner of the embodiment of the present invention, the drug releasing portion includes a light-induced topology material layer, the drug is stored in the light-induced topology material layer, and the light-induced topology material layer is configured to convert an internal molecular structure from a cage structure to a chain structure under an irradiation effect of the light of the first color emitted by the light emitting portion, so that the drug is released from the light-induced topology material layer.
In another implementation manner of the embodiment of the present invention, the light-induced topology material layer is further configured to, under an irradiation effect of light of a second color emitted by the light emitting portion, convert an internal molecular structure from a chain structure to a cage structure, so that the drug is locked in the light-induced topology material layer, where the light of the first color and the light of the second color are monochromatic lights of different colors.
In another implementation of an embodiment of the invention, the layer of phototopology material includes a polymer complex of a dithienylethylene group and a palladium ion.
In another implementation manner of the embodiment of the present invention, the medicine releasing portion includes a medicine storing cavity with an opening, a metal door for blocking the opening, and a control component, the control component includes a photo-magnetic material, and the photo-magnetic material is configured to generate magnetism to drive the metal door to open under the irradiation of the light emitted by the light emitting portion, so that the medicine is released from the medicine storing cavity.
In another implementation manner of the embodiment of the present invention, the drug release portion includes a drug storage cavity having an opening and a blocking structure blocking the opening, the blocking structure includes a photodecomposition material configured to be decomposed by irradiation of light emitted by the light emitting portion, so that the drug can be released from the opening of the drug storage cavity.
In another implementation manner of the embodiment of the invention, the light emitting part comprises at least 1 display substrate, and the medicine releasing part is arranged on the display substrate.
In another implementation of the embodiment of the invention, the light emitting region includes 1 display substrate configured to be able to emit monochromatic light of one color, or the display substrate is configured to be able to selectively emit monochromatic light of two different colors.
In another implementation manner of the embodiment of the present invention, the light emitting portion includes 2 display substrates, the 2 display substrates are respectively located at two sides of the medicine releasing portion, the display substrates are configured to be capable of emitting monochromatic light of one color, and the monochromatic light emitted by the display substrates located at two sides of the medicine releasing portion is different or the same in color.
In another implementation manner of the embodiment of the present invention, the light emitting portion includes 2 display substrates, the 2 display substrates are respectively located at two sides of the medicine releasing portion, and the display substrates are configured to be capable of selectively emitting monochromatic lights of two different colors.
In another implementation manner of the embodiment of the present invention, the display substrates include at least one first light emitting unit and at least one second light emitting unit, the two display substrates are configured such that an irradiation area of monochromatic light of a first color emitted by all the first light emitting units is the same as an irradiation area of monochromatic light of a second color emitted by all the second light emitting units, an orthographic projection of the first light emitting unit on one display substrate on the other display substrate coincides with the second light emitting unit on the other display substrate, or an orthographic projection of the first light emitting unit on one display substrate on the other display substrate coincides with the first light emitting unit on the other display substrate.
In another implementation manner of the embodiment of the present invention, the display substrate includes an array substrate, an irradiation layer, a transparent cathode layer, and a transparent encapsulation layer, which are sequentially stacked, and the transparent encapsulation layer is attached to the side surface of the drug release portion.
In another aspect, embodiments of the present invention provide a capsule endoscope comprising a drug release device as described above.
The technical scheme provided by the embodiment of the invention has the following beneficial effects:
the medicine releasing device comprises a light emitting part and a medicine releasing part, wherein the light emitting part can emit light for irradiating the medicine releasing part, the medicine is stored in the medicine releasing part, and the medicine stored in the medicine releasing part can be released by the medicine releasing part under the irradiation of the light emitted by the light emitting part, so that the aim of controlling the medicine releasing time is fulfilled. When the capsule endoscope is used, the medicine releasing device enters a human body along with the capsule endoscope, and when the capsule endoscope moves to a proper position, the medicine releasing part is made to emit light by controlling the light emitting part, so that the medicine stored in the medicine releasing part is released to the proper position in the human body under the irradiation of the light, the aim of accurately releasing the medicine in the human body is fulfilled, and the use requirement of the capsule endoscope is met.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic view of a drug delivery device of a capsule endoscope according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a photo-topological substrate according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of a photo-topological substrate according to an embodiment of the present invention;
fig. 4 is a schematic diagram of a topology network conversion of a photo-induced topology material according to an embodiment of the present invention;
FIG. 5 is a schematic structural diagram of a drug release device of a capsule endoscope provided by an embodiment of the present invention;
fig. 6 is a schematic structural diagram of a display substrate according to an embodiment of the present invention;
FIG. 7 is a schematic structural diagram of a drug release device of a capsule endoscope according to an embodiment of the present invention;
FIG. 8 is a schematic structural diagram of a drug release device of a capsule endoscope according to an embodiment of the present invention;
FIG. 9 is a schematic structural diagram of a drug release device of a capsule endoscope according to an embodiment of the present invention;
fig. 10 is a schematic structural diagram of an array substrate according to an embodiment of the present invention;
figure 11 is a flow chart illustrating a method of manufacturing a drug delivery device according to embodiments of the present invention;
FIG. 12 is a schematic structural diagram of a drug release device of a capsule endoscope according to an embodiment of the present invention;
figure 13 is a schematic structural view of a drug release portion provided in an embodiment of the present invention;
figure 14 is a schematic structural view of a drug release portion provided by an embodiment of the present invention;
fig. 15 is a schematic structural diagram of a capsule endoscope provided in an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.
The capsule endoscope is a medical appliance, and is placed in the digestive tract of a human body when in use, and the built-in camera shooting part is used for shooting and obtaining images so as to fulfill the aim of seeing the health condition of the intestines, stomach and esophagus of the human body.
There is a capsule endoscope among the related art, this capsule endoscope includes being capsule-shaped casing, the unit of making a video recording, power, data transmission unit and the control unit, and the unit of making a video recording, power, signal transmission unit and the control unit all are located the casing. One end of the shell is a transparent end cover, and the camera shooting unit positioned in the shell can shoot images outside the capsule endoscope through the transparent end cover. The power supply is electrically connected with the camera shooting unit, the signal transmission unit and the control unit and supplies electric energy to the camera shooting unit, the signal transmission unit and the control unit. The control unit is electrically connected with the camera shooting unit and is used for controlling the camera shooting unit to act and acquiring the shot image data. The control unit is also electrically connected with the data transmission unit and is used for transmitting the acquired image data to the outside of the human body through the data transmission unit so as to be convenient for technical staff to analyze and use. Because this capsule endoscope does not possess the function of storage medicine and the accurate release medicine in suitable position, be difficult to satisfy the in-service use demand.
In other related technologies, the capsule endoscope is further provided with an electromagnet, and the electromagnet can push a drug release door arranged at an opening of the capsule endoscope to open in a power-on state, so as to achieve the purpose of releasing the drug stored in the capsule endoscope. However, the capsule endoscope uses the electromagnet, which increases the mass of the capsule endoscope, is not favorable for realizing light and miniature capsule endoscope, and increases the processing and manufacturing cost.
The embodiment of the invention provides a medicine release device of a capsule endoscope. Fig. 1 is a schematic view of a drug release device of a capsule endoscope provided by an embodiment of the invention. As shown in fig. 1, the drug release device comprises: a light emitting part A for emitting light, and a drug releasing part B configured to release a drug stored in the drug releasing part B by irradiation of the light emitted by the light emitting part A.
As shown in the left half of FIG. 1, the light-emitting part A does not emit light, and the drug M is stored in the drug-releasing part B. As shown in the right half of FIG. 1, the light-emitting part A emits light, and the drug-releasing part B releases the drug M. In fig. 1, the light emitting part a and the drug releasing part B are spaced from each other, but the actual positional relationship between the two parts is not limited, and the light emitting part a and the drug releasing part B may be connected to each other (directly or indirectly), as long as the light emitted from the light emitting part a can be irradiated on the drug releasing part B, so that the drug releasing part B releases the drug M.
The medicine releasing device comprises a light emitting part and a medicine releasing part, wherein the light emitting part can emit light for irradiating the medicine releasing part, the medicine is stored in the medicine releasing part, and the medicine stored in the medicine releasing part can be released by the medicine releasing part under the irradiation of the light emitted by the light emitting part, so that the aim of controlling the medicine releasing time is fulfilled. When the capsule endoscope is used, the medicine releasing device enters a human body along with the capsule endoscope, and when the capsule endoscope moves to a proper position, the medicine releasing part is made to emit light by controlling the light emitting part, so that the medicine stored in the medicine releasing part is released to the proper position in the human body under the irradiation of the light, the aim of accurately releasing the medicine in the human body is fulfilled, and the use requirement of the capsule endoscope is met.
In addition, compared with the mode of controlling the medicine release by the electromagnet, the mode of controlling the medicine release by the medicine release part of the capsule endoscope does not need to be provided with the electromagnet, so that the quality of the capsule endoscope can not be greatly increased while the medicine release function is added on the capsule endoscope, and the light source with lighter weight, such as a miniature display panel, can be adopted by the light emitting part added on the capsule endoscope, so the light weight and the miniaturization of the capsule endoscope are conveniently realized.
Optionally, the drug release portion may include a light-induced property material configured to change a physical property of the material upon irradiation with light, such that the drug is released from the drug release portion. Wherein the physical property may be: physical properties of the material (e.g., magnetic, solubility, etc.), the internal molecular structure of the material.
In some embodiments of the present invention, the light-induced characteristic material layer may be a light-induced topology material layer in which the drug is stored, and the light-induced topology material layer is configured such that the internal molecular structure is converted from a cage structure to a chain structure under the irradiation of the light of the first color emitted from the light-emitting portion a, so that the drug is released from the light-induced topology material layer. Through the irradiation effect of the light with the first color, the internal molecular structure of the photoinduced topological material layer is converted from a cage structure into a chain structure, so that the medicine locked in the cage structure can be released from the photoinduced topological material layer. Thus, the aim of controlling the medicine release time can be realized by illumination, and the use requirement of the capsule endoscope is met.
Optionally, the light-induced topology material layer is configured to convert an internal molecular structure from a chain structure to a cage structure under an irradiation effect of light of a second color emitted by the light emitting portion a, so that the drug is locked in the light-induced topology material layer, and the light of the first color and the light of the second color are monochromatic lights of different colors. Through the irradiation effect of the light with the second color, the internal molecular structure of the photoinduced topological material layer is converted into a cage-shaped structure from a chain-shaped structure, so that the medicine can be locked in the cage-shaped structure again, the aim of controlling the medicine to stop releasing is fulfilled, the medicine release amount is controlled, and the applicability of the capsule endoscope is improved. Meanwhile, the photoinduced topological material layer can be converted into a cage-shaped structure from a chain structure again, and after the release of the medicine in the medicine release part B is finished, the medicine can be stored in the photoinduced topological material layer again, so that the aim of reusing the capsule endoscope can be fulfilled.
Alternatively, the layer of phototopology material may comprise a macromolecular complex of a dithienylethylene group and a palladium (Pd) ion. The topological network can realize the reversible conversion between a cage structure and a chain structure, namely, under the irradiation of ultraviolet light and green light, the photoinduced topological material layer can be converted into the chain structure from the cage structure or converted into the cage structure from the chain structure. Pd ions in the macromolecular complex are used for forming cage bones with cage structures in a topological network, and the dithienyl vinyl groups are attached to the cage bones formed by the Pd ions, so that the Pd ions and the cage bones form the topological network together.
Illustratively, when the photoinduced topological material layer containing the dithienyl vinyl group and the Pd ion polymer complex is irradiated by ultraviolet light (light of a second color), the internal molecular structure of the photoinduced topological material layer is converted from a chain structure into a cage structure, and the drug is locked in the photoinduced topological material layer; when the light-induced topological material layer is irradiated by green light (light of the first color), the internal molecular structure of the light-induced topological material layer is converted into a chain structure from a cage structure, and the light-induced topological material layer releases the drug stored in the light-induced topological material layer.
Exemplarily, fig. 2 is a schematic structural diagram of a light-induced topological substrate according to an embodiment of the present invention. As shown in fig. 2, the drug release portion comprises a light-induced topology substrate 2, and the light-induced topology substrate 2 comprises a substrate 2a, a light-induced topology material layer 2b located on the substrate 2a, and an encapsulating layer 2c for encapsulating the light-induced topology material layer 2b on the substrate 2 a.
Exemplarily, fig. 3 is a schematic structural diagram of a light-induced topological substrate according to an embodiment of the present invention. As shown in fig. 3, the drug release portion comprises a photo-topological substrate 2, and the photo-topological substrate 2 comprises a substrate 2a, a photo-topological material layer 2b on the substrate 2a, and another substrate 2a for encapsulating the photo-topological material layer 2b on the substrate 2 a. Namely, the photoinduced topological substrate 2 is packaged in a mode that the two substrate substrates 2a are butted, and the photoinduced topological material layer 2b of the photoinduced topological substrate 2 is formed between the two substrate substrates 2a, so that the packaging mode has a better protection effect on the photoinduced topological material layer 2b, and the stability of the photoinduced topological substrate 2 is improved.
In this example, the size of the cage structure of the polymer complex depends on the number of palladium atoms and ligands of the polymer complex. And the more the number of palladium atoms and ligands is, the larger the cage structure of the polymer complex is, so that the loading of more drugs can be met.
Illustratively, as shown in fig. 4, the polymer complex of the dithienylethylene group and the Pd ion has 24 palladium atoms and 48 ligands, and when irradiated by ultraviolet light, the polymer complex has a cage structure, and the 24 palladium atoms and the 48 ligands are all bonded together. When the polymer complex is irradiated by green light, the polymer complex is in a chain structure, and 24 palladium atoms and 48 ligands are dispersed into 8 ligands with 3 palladium atoms and 6 ligands.
In other embodiments, the polymer complex of the dithienylethylene group and the Pd ion may further have 12 Pd atoms and 24 ligands, and the size of the cage structure formed by the polymer complex is smaller than that of the polymer complex of 24 Pd atoms and 48 ligands, so that the amount of the drug which can be loaded is relatively small. How the palladium atom and the ligand are specifically configured can be determined according to the requirements of drug loading, and the invention is not limited.
In the embodiments shown in fig. 2 and 3, a photo-topological substrate is used as the drug release portion, and the light emitting portion adapted to such a drug release portion may be a display substrate. The display substrate is adopted as the light-emitting part of the photoinduced topological substrate, and the surface light source can be emitted to the photoinduced topological substrate, so that the light-emitting part can uniformly irradiate the photoinduced topological substrate. And the display substrate is plate-shaped, so that the display substrate is easier to be arranged on the plate-shaped photoinduced topological substrate.
In some other implementations, the Light Emitting part may be an independent Light source, such as an LED (Light Emitting Diode), and the embodiment is not limited thereto.
The light-emitting part is taken as an example of a display substrate to describe the light-emitting part in detail, the light-emitting part may include at least 1 display substrate, and the medicine releasing part is on the display substrate. The drug release part B of the photoinduced topological substrate can be arranged on the side surface of the display substrate, so that when the display substrate emits light, the light can irradiate the photoinduced topological substrate and the photoinduced topological material layer on the photoinduced topological substrate, and the drugs in the photoinduced topological material layer are released.
In one possible embodiment, the light emitting part a includes 1 display substrate 1, and 1 display substrate 1 is located at one side of the medicine releasing part B. That is, the light emitting portion a includes 1 display substrate 1, and the display substrate 1 is located on the side of the light induced topology substrate 2.
Illustratively, as shown in fig. 5, the display substrate 1 includes an array substrate 11, an irradiation layer 12, a transparent cathode layer 13 and a transparent encapsulation layer 14, which are sequentially stacked, and the transparent encapsulation layer 14 is attached to one side surface of the photo-induced topology substrate 2 and can emit a surface light source to the photo-induced topology material layer, thereby improving the response speed of the photo-induced topology material layer.
In this embodiment, the drug release portion is a photo-topology substrate, and the photo-topology material layer of the photo-topology substrate is a material layer of a polymer complex containing a dithienyl vinyl group and a Pd ion. Therefore, the display substrate can emit monochromatic light with at least 1 color, and when the display substrate emits the monochromatic light with the color to irradiate the photoinduced topological substrate, the photoinduced topological substrate can smoothly release the medicine.
Alternatively, the display substrate 1 is configured to be capable of emitting monochromatic light of one color. For example, when the display substrate can emit only 1 color of monochromatic light, the color of monochromatic light may be green light.
Illustratively, the photo-topological material layer is a material layer containing a polymer complex of a dithienyl vinyl group and a Pd ion, and the display substrate can emit only green light for controlling the photo-topological substrate to release the drug. Since the display substrate cannot emit light for controlling the photo topology substrate to stop releasing the drug, when the display substrate emitting only monochromatic light is adopted, the amount of the drug stored in the photo topology substrate needs to be accurately controlled, so as to avoid excessive or insufficient amount of the drug released. Because the display substrate only emits green light, compared with a display substrate capable of emitting light with various colors, the material doped in the light-emitting layer in the display substrate is easier to obtain, the manufacturing is convenient, and the cost is saved.
Alternatively, the display substrate 1 is configured to be capable of selectively emitting monochromatic light of two different colors. For example, when the display substrate can emit monochromatic light of two different colors, the monochromatic light of two colors can include green light and ultraviolet light.
Illustratively, the photoinduced topological material layer in the photoinduced topological substrate is a material layer of a macromolecular complex containing a dithienyl vinyl group and Pd ions, when the display substrate emits green light, a topological network of the photoinduced topological material layer in the photoinduced topological substrate is converted into a chain structure from a cage structure, the photoinduced topological substrate releases a drug, when the display substrate emits ultraviolet light, the topological network of the photoinduced topological material layer in the photoinduced topological substrate is converted into the cage structure from the chain structure, and the photoinduced topological substrate locks the drug therein and stops releasing the drug. Because the display substrate can emit ultraviolet light for controlling the photoinduced topological substrate to stop releasing the drugs, when the display substrate capable of emitting light of two colors is adopted, the amount of the drugs stored in the photoinduced topological substrate does not need to be accurately controlled, and the amount of the drugs released is controlled by controlling the photoinduced topological substrate to release or stop releasing the drugs in real time during drug release. Because the display substrate can emit green light and ultraviolet light, the display substrate is more convenient to use compared with a display substrate only emitting monochromatic light.
The above example may be implemented in such a manner that the display substrate may include a plurality of first light emitting units and a plurality of second light emitting units, the plurality of first light emitting units are distributed in an array, the plurality of second light emitting units are distributed in an array, the plurality of first light emitting units are configured to emit monochromatic light of a first color, and the second light emitting units are configured to emit monochromatic light of a second color. When the display substrate emits 2 different colors of light through the first light emitting units and the second light emitting units which are distributed in an array manner, the first light emitting units and the second light emitting units which emit different colors are distributed on the display substrate in an array manner, so that the light can be uniformly irradiated on the photoinduced topological material layer.
For example, the display substrate may include a plurality of rows of first light emitting cells and second light emitting cells, the first light emitting cells emitting green light, and the second light emitting cells emitting ultraviolet light. As shown in fig. 6, the first row N1 is a first light emitting unit, the second row N2 is a second light emitting unit, and the third row N3 is a first light emitting unit, and so on, the light emitting units emitting green light and ultraviolet light are arranged at intervals, when it is necessary to control the display substrate 1 to emit green light, the rows of the first light emitting units can be controlled to emit green light, and when it is necessary to control the display substrate 1 to emit ultraviolet light, the rows of the second light emitting units can be controlled to emit ultraviolet light. Thereby achieving the purpose that the display substrate can emit light of 2 colors.
In one possible embodiment, the light emitting part a includes 2 display substrates, and the 2 display substrates are respectively located at both sides of the medicine releasing part B. That is, the light emitting portion a includes 2 display substrates, and the 2 display substrates are respectively located on two opposite side surfaces of the photo-topology substrate.
Illustratively, as shown in fig. 7, both display substrates 1 include an array substrate 11, an irradiation layer 12, a transparent cathode layer 13, and a transparent encapsulation layer 14, which are sequentially stacked. The transparent packaging layers 14 of the two display substrates 1 are respectively attached to two opposite side surfaces of the photoinduced topological substrate 2, so that the two display substrates 1 can emit surface light sources to the photoinduced topological material layer, and the response speed of the photoinduced topological material layer is improved.
Optionally, the display substrate is configured to be capable of emitting monochromatic light of one color. And because the photoinduced topological material layer is a material layer of a macromolecular complex containing a dithienyl vinyl group and Pd ions, the colors of the monochromatic light emitted by the display substrates positioned at the two sides of the medicine release part are different or the same.
First, both display substrates emit only green light for controlling the release of the drug from the photo-topological substrate. Because the two sides of the photo-induced topological substrate are irradiated simultaneously, the response speed of the photo-induced topological substrate can be further improved. And because the display substrate can not emit light for controlling the photoinduced topological substrate to stop releasing the drugs, when the display substrate only emitting monochromatic light is adopted, the amount of the drugs stored in the photoinduced topological substrate is accurately controlled so as to avoid excessive or insufficient amount of the released drugs. Because the display substrate only emits green light, compared with a display substrate capable of emitting light with various colors, the material doped in the light-emitting layer in the display substrate is easier to obtain, the manufacturing is convenient, and the cost is saved. The display substrate may include one light emitting unit, or include a plurality of light emitting units distributed in an array, and one or more light emitting units may emit green light to illuminate the photo-topology substrate simultaneously.
Second, one of the two display substrates may emit green light and the other of the two display substrates may emit ultraviolet light. Thus, the two display substrates can be used for controlling the photoinduced topological substrate to release the medicine and controlling the photoinduced topological substrate to stop releasing the medicine respectively. Because the display substrate can emit ultraviolet light for controlling the photoinduced topological substrate to stop releasing the drugs, when the combination of the display substrate is adopted, the amount of the drugs stored in the photoinduced topological substrate does not need to be accurately controlled, and the amount of the released drugs is controlled by controlling the photoinduced topological substrate to release or stop releasing the drugs in real time during drug release. Since the two display substrates can emit green light and ultraviolet light, the combination of the display substrates emitting monochromatic light of different colors, respectively, is more convenient to use than the combination of two display substrates emitting only green light. The display substrate may include one light emitting unit or a plurality of light emitting units distributed in an array, and one light emitting unit or a plurality of light emitting units on the same display substrate may emit green light or ultraviolet light to irradiate the photo-induced topology substrate simultaneously.
Optionally, each display substrate is configured to be capable of selectively emitting monochromatic light of two different colors. And because the photoinduced topological material layer is a material layer of a macromolecular complex containing a dithienyl ethylene group and Pd ions, the two display substrates can both emit green light and ultraviolet light. For example, when the drug needs to be released, green light can be emitted from two sides of the photoinduced topological substrate at the same time, so that the green light on the whole surface can be emitted from two sides of the photoinduced topological material layer at the same time, the response speed of the photoinduced topological material layer can be improved, and the drug can be released in time; meanwhile, when the release of the drugs needs to be stopped, ultraviolet light can be emitted from two sides of the photoinduced topological substrate at the same time, and the ultraviolet light of the whole surface is emitted to two sides of the photoinduced topological material layer at the same time, so that the response speed of the photoinduced topological material layer can be increased, the drugs can be conveniently and timely stopped to be released, and the drugs are prevented from being released too much or too little due to the problem of the response speed of the photoinduced topological material layer.
The following implementation modes can be adopted to realize that the display substrate can selectively emit monochromatic light with two different colors:
optionally, the display substrates include at least one first light emitting unit and at least one second light emitting unit, and the two display substrates are configured such that the irradiation area of the monochromatic light of the first color emitted by all the first light emitting units is the same as the irradiation area of the monochromatic light of the second color emitted by all the second light emitting units. The irradiation area refers to an area on the photo-topology substrate, which is irradiated by light. The areas of the two display substrates, which are irradiated by all the first light-emitting units and all the second light-emitting units, on the photoinduced topological substrate are the same, so that the photoinduced topological substrate can be subjected to the same illumination effect when the display substrates emit monochromatic lights with the same or different colors. Meanwhile, because the irradiation areas of different light-emitting units are the same, the photoinduced topological substrate can be irradiated by the same whole light, so that light can be uniformly irradiated on the photoinduced topological substrate.
In one possible implementation, the orthographic projection of the first light-emitting unit on one display substrate on the other display substrate coincides with the first light-emitting unit on the other display substrate.
For example, the display substrate may include a plurality of first light emitting units and a plurality of second light emitting units, the plurality of first light emitting units are distributed in an array, the plurality of second light emitting units are distributed in an array, the plurality of first light emitting units are configured to emit monochromatic light of a first color, the second light emitting units are configured to emit monochromatic light of a second color, an orthographic projection of the first light emitting unit on one display substrate on another display substrate coincides with the first light emitting unit on another display substrate, and an orthographic projection of the second light emitting unit on one display substrate on another display substrate coincides with the second light emitting unit on another display substrate.
When the display substrate emits 2 different colors of light through the first light emitting units and the second light emitting units which are distributed in an array manner, the first light emitting units and the second light emitting units which emit different colors are distributed on the display substrate in an array manner, so that the light can be uniformly irradiated on the photoinduced topological material layer. Meanwhile, because the orthographic projection of the first light-emitting unit on one display substrate on the other display substrate is superposed with the first light-emitting unit on the other display substrate, the two sides of the photoinduced topology substrate can be ensured to be subjected to the same illumination effect when the two display substrates emit light with the same color.
For example, the display substrate may include a plurality of rows of first light emitting cells and second light emitting cells, the first light emitting cells emitting green light, and the second light emitting cells emitting ultraviolet light. As shown in fig. 6, the first row N1 is a first light emitting unit, the second row N2 is a second light emitting unit, and the third row N3 is a first light emitting unit, and so on, the light emitting units emitting green light and ultraviolet light are arranged at intervals, when it is necessary to control the display substrate 1 to emit green light, the rows of the first light emitting units can be controlled to emit green light, and when it is necessary to control the display substrate 1 to emit ultraviolet light, the rows of the second light emitting units can be controlled to emit ultraviolet light. Thereby achieving the purpose that the display substrate can emit light of 2 colors.
In another possible implementation, the orthographic projection of the first light-emitting unit on one display substrate on the other display substrate coincides with the second light-emitting unit on the other display substrate.
For example, the display substrate may include a first light emitting unit for emitting monochromatic light of a first color and a second light emitting unit for emitting monochromatic light of a second color. Because the orthographic projection of the first light-emitting unit on one display substrate in the 2 display substrates on the other display substrate is superposed with the second light-emitting unit on the other display substrate, when the display substrates are controlled to emit a monochromatic light, the first light-emitting units in different areas on the 2 display substrates can be controlled to emit light simultaneously, so that the photoinduced topological material layer can still be irradiated by the whole light, and the light can be uniformly irradiated on the photoinduced topological material layer.
Wherein the number of the first light emitting unit and the second light emitting unit of the display substrate may be at least one.
For example, as shown in fig. 8, each display substrate 1 includes one first light emitting unit and one second light emitting unit, and 2 display substrates 1 each include a left light emitting half-region L and a right light emitting half-region R, wherein the left light emitting half-region L of one display substrate 1 is arranged with the first light emitting unit, and the right light emitting half-region R is arranged with the second light emitting unit; and the left light-emitting half L of the other display substrate 1 is disposed with a second light-emitting unit, and the right light-emitting half R is disposed with a first light-emitting unit that emits green light and a second light-emitting unit that emits ultraviolet light. Since the left light-emitting half-area L and the right light-emitting half-area R of the two display substrates 1 are complementary, when the two display substrates 1 emit green light or ultraviolet light at the same time, the photo-induced topology material layer in the photo-induced topology material substrate 2 can be irradiated by the whole light.
For example, as shown in fig. 9, each display substrate 1 includes 2 first light emitting cells and 2 second light emitting cells, and each of the 2 display substrates 1 includes a first light emitting region X1, a second light emitting region X2, a third light emitting region X3, and a fourth light emitting region X4, wherein the first light emitting region X1 and the fourth light emitting region X4 of one display substrate 1 are disposed as the first light emitting cells, and the second light emitting region X2 and the third light emitting region X3 are disposed as the second light emitting cells; and the first light emitting region X1 and the fourth light emitting region X4 of the other display substrate 1 are disposed as second light emitting cells, and the second light emitting region X2 and the third light emitting region X3 are disposed as first light emitting cells, the first light emitting cells emitting green light, and the second light emitting cells emitting ultraviolet light. Since the first light-emitting region X1, the fourth light-emitting region X4, the second light-emitting region X2 and the third light-emitting region X3 of the two display substrates 1 are complementary, when the two display substrates 1 emit green light or ultraviolet light at the same time, the photo-topology material layer in the photo-topology substrate 2 can be irradiated with the whole light.
Alternatively, the display substrate may be a light emitting panel emitting light of the same color over the entire surface, and when the display substrate is controlled to emit light of different colors, forward and reverse voltages may be applied to the display substrate to control the display substrate to emit light of 2 different colors. For example, in a cathode-anode composite electrochromic device using a phenothiazine derivative as an anode electrochromic material and viologen as a cathode electrochromic material, the anode material shows blue when a forward cathode material is applied and shows red when a reverse voltage is applied, and the purpose of emitting 2 different colors of light is achieved.
Exemplarily, in the embodiments shown in fig. 5 and 6, the display substrate 1 may include an array substrate 11, an irradiation layer 12, a transparent cathode layer 13, and a transparent encapsulation layer 14, which are sequentially stacked.
Fig. 10 is a schematic structural diagram of an array substrate according to an embodiment of the present invention. The array substrate 11 may be a TFT (Thin Film Transistor) substrate. Illustratively, as shown in fig. 10, the TFT substrate may include a substrate 110, an active layer 111, a gate insulating layer 112, a gate layer 113, an interlayer dielectric layer 114, a source drain layer 115, and an anode layer 116, which are sequentially stacked. The TFT substrate may be implemented by using a semiconductor mask process, which is not described in detail in this embodiment.
It should be noted that, in the example, only the TFT substrate structure with the single gate layer 113 is illustrated, and the TFT substrate structure may also be a plurality of structures such as the double gate layer 113, and the embodiment of the present invention is not limited herein.
Alternatively, the anode layer 116 of the TFT substrate may be a reflective anode, so that after the light emitting layer emits light, the reflective anode can reflect part of the light emitted by the light emitting layer back, so that more light can be emitted from the emitting direction, thereby improving the light emitting effect of the display substrate 1. The reflective anode can be processed and manufactured by magnetron sputtering, atomic deposition, evaporation and other modes. And the material of the reflecting anode can be Al, Ag, graphene, Al/ITO, ITO/Al/ITO, Ag/ITO, ITO/Ag/ITO, Ag/Alq3/Ag/Alq3/Ag and other materials.
Alternatively, the array substrate 11 of the TFT substrate may be a rigid substrate, for example, a glass substrate, or a flexible substrate, for example, a PI (Polyimide) substrate.
The irradiation Layer 12 may include a Hole Injection Layer (HIL), a Hole Transport Layer (HTL), an Electron Blocking Layer (EBL), a light emitting Layer (EML), a Hole Blocking Layer (HBL), an Electron Transport Layer (EHL), and an Electron Injection Layer (EIL).
In this embodiment, the irradiation layer 12 is located between the anode layer 116 and the transparent cathode layer 13, after the array substrate 11 is powered on, the anode layer 116 releases holes, and the holes sequentially pass through the hole injection layer and the hole transport layer and enter the light emitting layer. Meanwhile, the cathode releases electrons, the electrons sequentially pass through the electron injection layer and the electron transport layer to enter the light-emitting layer, and meanwhile, an electron blocking layer can be arranged in the light-emitting layer to prevent the electrons from leaving the light-emitting layer. The electrons and the holes are converged in the light-emitting layer to generate a recombination effect, excitons are generated in the recombination process, the excitons migrate under the action of an electric field to transfer energy to the light-emitting layer, and the light-emitting layer can finally generate photons to emit light with different colors according to the difference of photon energy.
Among them, the electron injection layer/hole injection layer can lower the barrier for injecting electrons/holes from the cathode/anode, enabling the electrons/holes to be efficiently injected from the cathode/anode into the light-emitting layer.
Among them, the electron transport layer/hole transport layer can control the electron/hole transport speed. Since the transport rate of the holes is greater than that of the electrons, the transport rates of the electrons and the holes are reasonably controlled to ensure that the electrons and the holes can be recombined in the light-emitting layer.
Alternatively, the irradiation layer 12 may include one or more of a hole injection layer, a hole transport layer, an electron blocking layer, a light emitting layer, a hole blocking layer, an electron transport layer, and an electron injection layer. The irradiation layer 12 includes at least a light-emitting layer to satisfy the light emission requirement of the irradiation layer 12.
Alternatively, the transparent cathode layer 13 may be made of ITO, IZO, Ag, Mg: Ag, Al: Ag, Yb: Ag, a combination thereof, or the like. The method can be realized by selecting modes such as magnetron sputtering, vacuum evaporation and the like according to the material characteristics. Since the cathode layer is transparent, the light emitted from the irradiation layer 12 can be emitted to the outside of the display substrate 1 through the cathode layer, so as to maintain a good light emission effect.
Alternatively, the transparent encapsulating layer 14 may be made of SiNX, SiCN, SiOx, HMDSO, IZO, Dam, Filler, Laser Frit, or a combination thereof, which may be implemented by CVD, PVD, Dam & Fill, or the like, depending on the material characteristics. Since the encapsulation layer is transparent, the light emitted from the illumination layer 12 can be emitted out of the display substrate 1 through the encapsulation layer, so as to maintain a good light-emitting effect.
It should be noted that the display substrate 1 is only an example, and besides an OLED (Organic Light-Emitting Diode) display substrate, a QLED (Quantum Dot Light-Emitting Diode), a Micro OLED (Micro Organic Light-Emitting Diode), and other display substrates may be used, and the embodiment of the present invention is not limited herein.
The embodiment of the invention provides a preparation method of a medicine release device, which is used for preparing the medicine release device shown in figures 5 and 6, and as shown in figure 11, the preparation method comprises the following steps:
step S1: a base substrate is provided.
Wherein, the substrate base plate can be a transparent base plate. The substrate base plate is transparent, so that the photoinduced topological material layer in the substrate base plate can be irradiated through the substrate base plate after the display base plate emits light, so that the release of the medicine is controlled.
Step S2: a layer of photo-topological material is formed on a substrate base plate.
Alternatively, the solution is applied to the side of the substrate base by spraying, printing, spin coating, brushing, or the like.
Illustratively, the layer of photo-topology material may be formed in the following manner: to provide a polymer complex containing a dithienylethylene group and Pd2+A solution of a salt, wherein the solvent of the solution includes, but is not limited to, acetonitrile. The polymeric complexes may be multimetal oxide semiconductors (polymoocs).And then, coating the solution on a substrate, and forming a photoinduced topological material layer after the solution is attached to the substrate, thereby obtaining the photoinduced topological material layer of the macromolecular complex containing the dithienyl vinyl group and the Pd ions.
Alternatively, a polymer complex and Pd2+The salt ratio may be 1:1 to 4: 1. Polymer complex and Pd2+When the salt ratio is in the range of 1:1 to 4:1, after the coating is carried out on the substrate, the photoinduced topological material layer formed on the substrate can keep good reversible conversion properties of a cage structure and a chain structure, so that the dithienyl vinyl group polymer complex can be conveniently and efficiently used.
Illustratively, a macromolecular complex of a dithienylethylene group and Pd2+The salt ratio may be 1:1, 2:1, 3:1, 4:1, etc.
Step S3: the drug is sprayed on the layer of photo-topological material.
Wherein, the step S3 may include: spraying the medicine on the substrate to form the area of the photoinduced topological material layer, wherein the topological network of the high-molecular complex in the photoinduced topological material layer is in a chain structure, and irradiating the photoinduced topological material layer with ultraviolet light after spraying is finished to convert the high-molecular complex in the photoinduced topological material layer into a cage structure from the chain structure, so that the medicine is sealed and locked in the photoinduced topological material.
Step S4: and packaging the photoinduced topological material layer on the substrate to obtain the photoinduced topological substrate.
Illustratively, as shown in fig. 3, a brief description will be made of the packaging process of the photo-induced topology substrate having 2 substrate substrates: and providing another substrate, oppositely attaching the other substrate to the substrate on which the phototopography material layer is formed, and packaging the two substrates together.
When the two substrate base plates are packaged, at least one side edge of the two substrate base plates can be kept without packaging, so that the medicine stored in the photoinduced topological material layer can be released. The two substrate base plates can be transparent base plates, and the substrate base plates are transparent, so that the light-induced topological material layers in the substrate base plates can be irradiated through the substrate base plates after the light-emitting part emits light, and the release of the medicine can be controlled.
Step S5: attaching the display substrate on the side surface of the photoinduced topology substrate to obtain the drug release device.
In other implementations, to simplify the drug release device structure and reduce the manufacturing cost, the photo-induced topology material layer may be formed on the substrate of the display substrate and encapsulated on the substrate of the display substrate. Taking a drug delivery device with 2 display substrates as an example, as shown in fig. 12, the photo-topology material layer 2b is sandwiched between 2 display substrates, and the light-emitting layer 1a of the display substrate, the substrate 1b of the display substrate, the photo-topology material layer 2b, the substrate 1b of the display substrate, and the light-emitting layer 1a of the display substrate are arranged in the order from left to right in fig. 12, wherein the substrate 1b of the display substrate may be a transparent substrate. It can be seen that compared to the drug release device shown in fig. 6, the two substrate substrates 2a for encapsulating the photo-topology material layer 2b are reduced, the drug release device can be simplified, and the manufacturing cost can be reduced.
It should be noted that, when the drug release device is manufactured, the provided substrate is a display substrate, that is, the drug release device forms a light-induced topology material layer on the bottom surface of the substrate of the display substrate, and other manufacturing processes are consistent with the manufacturing method shown in fig. 11, which is not repeated herein.
In other embodiments of the present invention, the light-induced property material may be a magneto-optical material. Figure 13 is a schematic structural view of a drug release portion provided in the practice of the present invention. As shown in fig. 13, the drug releasing portion B may include a drug storage cavity 20 having an opening 25, a metal door movably located at the opening 25, and a control component 24, wherein the control component 24 includes a photo-magnetic material, and the photo-magnetic material is configured to generate magnetism to open the metal door under the irradiation of the light emitted from the light emitting portion a, so as to release the drug from the drug storage cavity 20. The physical properties of the photo-magnetic material in the control part 24 are changed by the irradiation of the light emitting part a, and magnetism is generated, and the metal door is driven to open by the magnetism of the photo-magnetic material, so that the medicine stored in the medicine storage cavity 20 is released. Thus, the aim of controlling the medicine release time can be realized by illumination, and the use requirement of the capsule endoscope is met. Compared with the electromagnet, the control mode can meet the medicine release function and reduce the quality of the capsule endoscope, thereby realizing the light weight and miniaturization of the capsule endoscope.
In this embodiment, the photo-magnetic material refers to a material whose magnetism changes under the condition of light irradiation. For example, magnetism is generated in the case of light irradiation, and magnetism is not generated in the case of no light irradiation.
Alternatively, the magneto-optical material may be ErCrO3, ferromagnetic/semiconducting mixtures, Prussian blue compounds, metal cyanides, and some other doped magnetic garnets. Different magneto-optical materials have some common characteristics: for most photomagnetic phenomena, magnetic ions, i.e., activation centers, can be in different valence states in a substance. For example, in doping YIG, if the impurity to be doped is Si, the activation center in this material is Fe2+Ion (Fe)2+—Fe3+) If the doped impurity is Ca or Pb, then Fe4+Ion (Fe)4+—Fe3+). In these materials, light absorption can result in charge transfer between magnetic and other ions. The result of the charge transfer may be to move the active centers to other locations or to cause a change in the concentration of active centers, which may ultimately result in a change in the material properties.
Illustratively, as shown in fig. 13, the medicine release portion B may include a medicine storage cavity 20 having an opening 25, a metal door movably positioned at the opening 25, and a control member 24. Wherein, the metal door can include sliding door 21 and the slide rail 22 that is located sliding door 21 both sides, sliding door 21 can make a round trip to slide on slide rail 22, and the both ends of two slide rails 22 are all connected fixedly through the spliced pole, is equipped with elasticity piece 23 that resets on one of them spliced pole, and elasticity resets 23's one end and is connected with sliding door 21, and elasticity resets 23's the other end and is connected with the spliced pole to can be equipped with control unit 24 on being connected with the spliced pole that elasticity resets 23.
When the medicine storage cavity is used, the sliding door 21 is positioned at the opening 25, the elastic resetting piece 23 is in an uncompressed or stretched state, when the light emitting part A emits light to irradiate the control part 24, the magneto-optical material in the control part 24 generates magnetism to attract the sliding door 21 to slide, so that the sliding door 21 overcomes the elasticity of the elastic resetting piece 23, the opening 25 of the medicine storage cavity 20 is opened, the medicine stored in the medicine storage cavity 20 is released, and the purpose of medicine release is achieved.
It should be noted that fig. 13 only shows an exemplary structure of a possible drug release portion and the arrangement relationship of each structure, and it is not limited that the drug release portion necessarily includes all the structures in the figure and satisfies the positional relationship of the structures, but only that the drug release portion includes a drug storage cavity with an opening, a metal door and a control component, so as to achieve the function of controlling the drug release of the drug release portion. For example, the metal door can also be a revolving door, and when the control part is illuminated and the internal magneto-optical material generates magnetism, the revolving door can be driven to rotate to open the revolving door.
In the following, the medicine releasing device is described in addition with the light emitting part, in this embodiment, the structure is adopted as the medicine releasing part, and the light emitting part adapted to the medicine releasing part may be a display substrate. The display substrate is used as the light emitting part, and the control part can emit a surface light source, so that the light emitted by the light emitting part can be uniformly irradiated on the photomagnetic material.
In some other implementations, the Light Emitting part may be an independent Light source, such as an LED (Light Emitting Diode) bulb, and the embodiment is not limited.
In this embodiment, when the light emitting portion is a display substrate, the light emitting portion may include at least 1 display substrate. Wherein, display substrate can also be attached on storing up the medicine cavity to display substrate's attached position needs to be guaranteed, can shine on the control unit when display substrate is luminous. When the display substrate emits light, the light can irradiate the magneto-optical material in the control component, and finally the medicine in the medicine storage cavity is released.
In other embodiments of the present invention, the photodefinable material can be a photodecomposition material. Fig. 14 is a schematic structural view of a drug release portion according to an embodiment of the present invention. As shown in fig. 14, the drug releasing part B may include a drug storage cavity 20 having an opening 25 and a blocking structure 26 for blocking the opening 25, and the control part 26 includes a photodecomposition material configured to decompose and expose the opening under the irradiation of the light emitted from the light emitting part a, so that the drug is released from the drug storage cavity 20. The photodecomposition material is decomposed by the irradiation of the light-emitting part a, so that the photodecomposition material in the blocking structure 26 is decomposed to expose the opening 25 of the drug storage cavity 20, thereby releasing the drug stored in the drug storage cavity 20. Thus, the aim of controlling the medicine release time can be realized by illumination, and the use requirement of the capsule endoscope is met. In addition, the control method only needs to arrange a layer of blocking structure 26 at the opening 25 of the medicine storage cavity 20, so that the quality of the capsule endoscope can be reduced to the maximum extent, and the weight and miniaturization of the capsule endoscope are realized.
Alternatively, the light decomposition material may be a material which undergoes cracking decomposition reaction under the action of light and gradually loses mechanical strength to achieve the purpose of decomposition. For example, a plastic made of a copolymer of an olefin and carbon monoxide. The light for irradiating the photodecomposition material may be white light, laser light, or the like.
In the following, the medicine releasing device is described in addition with the light emitting part, in this embodiment, the structure is adopted as the medicine releasing part, and the light emitting part adapted to the medicine releasing part may be a display substrate. The display substrate is used as a light emitting part, and can emit a surface light source for the blocking structure, so that light emitted by the light emitting part can be uniformly irradiated on the illumination decomposition material.
In some other implementations, the Light Emitting part may be an independent Light source, such as an LED (Light Emitting Diode), and the embodiment is not limited thereto.
In this embodiment, when the light emitting portion is a display substrate, the light emitting portion may include at least 1 display substrate, and the drug releasing portion is on the display substrate. Wherein, display substrate can be attached on storing up the medicine cavity to display substrate's attached position needs to be guaranteed, can shine on the block structure when display substrate is luminous. Therefore, when the display substrate emits light, the light can irradiate the light decomposition material in the blocking structure, and finally the medicine in the medicine storage cavity is released.
Illustratively, the display substrate may be disposed at a distance from the medicine storage cavity 20, and the light emitting surface of the display substrate is opposite to the blocking structure 26.
Embodiments of the present invention provide a capsule endoscope comprising a medicament release device as hereinbefore described.
Illustratively, as shown in fig. 15, the capsule endoscope may further include a capsule-like housing 31, an imaging unit 32, a power supply 33, a data transmission unit 34, and a control part 35, the imaging unit 32, the power supply 33, the data transmission unit 34, and the control part 35 being located within the housing. One end of the shell 31 is a transparent end cap, and the image pickup unit 32 in the shell can shoot images outside the capsule endoscope through the transparent end cap. The power supply 33 is electrically connected to the image pickup unit 32, the data transmission unit 34, and the control unit 35, the control unit 35 is electrically connected to the image pickup unit 32, and the control unit 35 is electrically connected to the data transmission unit 34. Wherein, the drug releasing device C can be placed at the other end of the shell 31, and the other end of the shell 31 can be provided with an opening for releasing the drug, which is opposite to the unencapsulated side edge of the photo-topological substrate (i.e. the drug releasing opening of the photo-topological substrate is opposite to the opening of the shell), so that the drug can be released from the inside of the capsule endoscope to the outside.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent replacements, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A drug delivery device for a capsule endoscope, the drug delivery device comprising: the drug release device comprises a light-emitting part (A) and a drug release part (B), wherein the light-emitting part (A) is used for emitting light, the drug release part (B) comprises a photoinduced topological material layer, drugs are stored in the photoinduced topological material layer, and the photoinduced topological material layer is configured to enable internal molecular structures to be converted into chain structures from cage structures under the irradiation effect of light of a first color emitted by the light-emitting part (A), so that the drugs are released from the photoinduced topological material layer.
2. A drug release device according to claim 1, wherein the photo-topological material layer is further configured to transform the internal molecular structure from a chain structure to a cage structure under the irradiation of the light of the second color emitted from the light emitting part (a), so that the drug is locked in the photo-topological material layer, and the light of the first color and the light of the second color are monochromatic lights of different colors.
3. A delivery device according to claim 2, wherein said layer of photo-topological material comprises a polymer complex of a dithienylethylene group and palladium ions.
4. A drug release device according to any of claims 1 to 3, characterized in that the light emitting part (a) comprises at least 1 display substrate (1), and the drug release part (B) is on the display substrate (1).
5. A drug delivery device according to claim 4, characterized in that the light emitting portion (A) comprises 1 display substrate (1), the display substrate (1) being configured to emit monochromatic light of one color, or the display substrate (1) being configured to selectively emit monochromatic light of two different colors.
6. A drug delivery device according to claim 4, wherein the light emitting portion (A) comprises 2 display substrates (1), the 2 display substrates (1) being respectively located at both sides of the drug delivery portion (B), the display substrates being configured to emit monochromatic light of one color, the monochromatic light emitted by the display substrates (1) located at both sides of the drug delivery portion (B) being different or the same color.
7. A medicament release device according to claim 4, wherein the light emitting portion (A) comprises 2 display substrates (1), the 2 display substrates (1) are respectively located at two sides of the medicament release portion (B), and the display substrates (1) are configured to selectively emit monochromatic light of two different colors.
8. A drug delivery device according to claim 7, characterized in that the display substrates (1) comprise at least one first and one second light emitting unit, the two display substrates (1) being arranged such that the illumination area of monochromatic light of a first color emitted by all first light emitting units is the same as the illumination area of monochromatic light of a second color emitted by all second light emitting units,
the orthographic projection of the first light-emitting unit on one display substrate (1) on the other display substrate (1) is overlapped with the second light-emitting unit on the other display substrate (1), or the orthographic projection of the first light-emitting unit on one display substrate (1) on the other display substrate (1) is overlapped with the first light-emitting unit on the other display substrate (1).
9. The device according to claim 4, wherein the display substrate (1) comprises an array substrate (11), an irradiation layer (12), a transparent cathode layer (13) and a transparent encapsulation layer (14) which are sequentially stacked, and the transparent encapsulation layer (14) is attached to the side surface of the drug release part (B).
10. A capsule endoscope, comprising a medicament release device according to any one of claims 1 to 9.
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| CN106974882A (en) * | 2017-03-07 | 2017-07-25 | 常州大学 | A kind of polypyrrole/mesoporous silicon oxide of core shell structure/application of the graphene quantum dot nano composite material in medicine controlled releasing |
| CN107033144A (en) * | 2017-04-25 | 2017-08-11 | 华中科技大学 | A kind of dithienyl ethene terylene acid imide near-infrared fluorescent molecular switch and preparation method thereof |
| CN207762750U (en) * | 2018-02-08 | 2018-08-24 | 中山市华凌照明有限公司 | Stainless steel lantern ceiling lamp |
| CN109171618A (en) * | 2018-10-31 | 2019-01-11 | 自贡德西玛医疗设备有限公司 | A kind of capsule endoscopic of releasable medicaments |
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