CN110208351A - A kind of method and device detecting hematocrit value - Google Patents
A kind of method and device detecting hematocrit value Download PDFInfo
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- CN110208351A CN110208351A CN201910551123.7A CN201910551123A CN110208351A CN 110208351 A CN110208351 A CN 110208351A CN 201910551123 A CN201910551123 A CN 201910551123A CN 110208351 A CN110208351 A CN 110208351A
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
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Abstract
The embodiment of the present application provides a kind of method for detecting hematocrit value, this method includes the impedance value IWB according to the circuit that working electrode, blank electrode and sample to be detected are constituted in sensor strip, and the impedance value IRB in the circuit of reference electrode, blank electrode and sample to be detected composition, obtain the impedance differences Δ I of IWB and IRB；According to the experimental data of impedance differences Δ I and hematocrit value, the functional relation of hematocrit value and impedance differences Δ I is obtained；Hematocrit value detection is carried out according to the functional relation of hematocrit value and impedance differences Δ I.Negative effect caused by the embodiment of the present application can reduce because of the inconsistent detection to hematocrit value of the carbon electrode thickness degree in sensor strip, the accuracy of hematocrit value detection is improved, and then improves the accuracy by detection hematocrit value as the obtained physiological diagnosis result of correction means.
Description
Technical field
The invention relates to technical field of data processing more particularly to a kind of methods and dress for detecting hematocrit value
It sets.
Background technique
For the electrochemica biological sensor strip of Physiological in vitro diagnosis, it typically is provided with working electrode, reference electrode and sky
White appliances extremely totally three electrodes.During detecting physiological signal, after sample to be detected enters sensor strip, sensor strip
Working electrode and blank electrode cooperate and obtain the initial signal of sample to be detected, reference electrode and blank electrode phase interworking
The background signal for obtaining sample to be detected is closed, initial signal, which subtracts background signal, can be obtained relatively accurate physiological signal.
It is general by obtaining sample to be detected in order to further increase the accuracy of detection physiological signal in prior art
Hematocrit value (HCT) to be corrected to testing result.The mode of currently used detection HCT is more by experiment acquisition
The impedance Value Data of group HCT value and sensor strip, and this multi-group data is carried out curve fitting to obtain HCT function, later
The impedance value of sensor strip and the circuit of sample to be detected composition can be brought into HCT function, to obtain sample to be detected
HCT value.
But in actual operation, the electric conductivity and manufacturing cost of electrode in order to balance, generally using carbon as electrode
Material is made, and during printing electrode, due to the limitation of printing technology itself, the thickness degree of carbon electrode not can avoid
Ground will appear inconsistent situation, therefore the impedance of the carbon electrode between different sensors strip will have differences, thus not
Impedance value with sensor strip and the circuit of sample to be detected composition also there is deviation, the sensing obtained in addition by experiment
Include the impedance value of electrode of sensor strip itself in the impedance Value Data of device strip, thus by by sensor strip with
The impedance value in the circuit of sample to be detected composition bring into the obtained sample to be detected of HCT function HCT value and sample to be detected
Actual HCT value will have deviation, thereby reduce the accuracy by the HCT physiological diagnosis result corrected.
Summary of the invention
In view of this, one of the technical issues of the embodiment of the present application is solved is the provision of a kind of hematocrit value detection
Method, pass through the inspection that the functional relation established between hematocrit value and the impedance of sample to be detected carries out hematocrit value
It surveys, negative effect caused by can reduce because of the inconsistent detection to HCT of the carbon electrode thickness degree in sensor strip improves
The accuracy of HCT detection, and then improve through detection HCT as the accurate of the obtained physiological diagnosis result of correction means
Degree.
In a first aspect, the embodiment of the present application provides a kind of method for detecting hematocrit value, the method is according to sensing
The impedance value IWB and reference electrode, blank in the circuit that working electrode, blank electrode and sample to be detected are constituted in device strip
The impedance value IRB in the circuit that electrode and sample to be detected are constituted, obtains the impedance differences Δ I of IWB and IRB；According to impedance differences
The experimental data of Δ I and hematocrit value obtain the functional relation of hematocrit value and impedance differences Δ I；According to red blood cell ratio
Hold and the functional relation of impedance differences Δ I carries out hematocrit value detection.
Optionally, the impedance differences Δ I is the absolute value of the difference of IWB and IRB | IWB-IRB |.
Optionally, the length of the reference electrode is more than or equal to the working electrode.
Second aspect, the embodiment of the present application also provides a kind of devices for detecting hematocrit value, including electrode detection mould
Block, impedance differences module, functional relation module and detection module, in which:
The electrode detection module is connected with the impedance differences module, for working electrode in detection sensor strip,
The impedance value IWB and reference electrode, blank electrode and sample structure to be detected in the circuit that blank electrode and sample to be detected are constituted
At circuit impedance value IRB, and the IWB and IRB that will test are sent to impedance differences module；
The impedance differences module is connected with the electrode detection module and functional relation module, is used for basis from electrode
The IWB and IRB that detection module obtains obtain the impedance differences Δ I of IWB and IRB, and obtained impedance differences Δ I are sent to
Functional relation module；
The functional relation module is connected with the impedance differences module and the detection module, is used for basis from impedance
The experimental data of impedance differences Δ I and hematocrit value obtained in difference block obtain hematocrit value and impedance differences Δ I
Functional relation, and obtained functional relation is sent to detection module；
The detection module is connected with the functional relation module, for according to obtained in from the functional relation module
The relationship of hematocrit value and impedance differences Δ I carry out hematocrit value detection.
The third aspect, the embodiment of the present application also provides a kind of storage medium, the storage medium includes the program of storage,
Wherein, the method for detection hematocrit value described above is executed when described program is run.
Fourth aspect the embodiment of the present application also provides a kind of electronic device, including memory, processor and is stored in institute
The computer program that can be run on memory and on the processor is stated, the processor is executed by the computer program
The method of detection hematocrit value described above.
By above technical scheme as it can be seen that the embodiment of the present application according to working electrode in sensor strip, blank electrode with to
Detect the resistance of the impedance value IWB and reference electrode in the circuit that sample is constituted, the circuit that blank electrode and sample to be detected are constituted
Anti- value IRB obtains the impedance differences Δ I of IWB and IRB, and the multipair impedance differences Δ I and red blood cell obtained by many experiments
The experimental data of specific volume obtains the functional relation of hematocrit value and impedance differences Δ I, multipair compared to passing through in prior art
The functional relation of hematocrit value and IWB or IRB that the experimental data of IWB or IRB and hematocrit value obtains, red blood cell
Linear relationship between the impedance of the sample of the function and sample to be detected of specific volume and impedance differences Δ I itself is most strong, therefore will
Hematocrit value function obtained in the embodiment of the present application is stored in advance in Physiological in vitro diagnostic instrments, detected red blood cell ratio
Capacitance is more accurate than the hematocrit value that prior art obtains.
Detailed description of the invention
Technical solution in ord to more clearly illustrate embodiments of the present application or in prior art, below will to embodiment or
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The some embodiments recorded in application embodiment can also obtain according to these attached drawings for those of ordinary skill in the art
Obtain other attached drawings.
Fig. 1 is the structural schematic diagram of the carbon electrode in the embodiment of the present application in sensor strip；
Fig. 2 is a kind of flow diagram for the method for detecting hematocrit value in the embodiment of the present application；
Fig. 3 A is the HCT function schematic diagram obtained in prior art according to the experimental data of HCT and IWB；
Fig. 3 B is the HCT function schematic diagram obtained in prior art according to the experimental data of HCT and IRB；
Fig. 3 C is the HCT function schematic diagram obtained in prior art according to the experimental data of HCT and impedance differences Δ I；
Fig. 4 is a kind of structural schematic diagram for the device for detecting hematocrit value in the embodiment of the present application；
Fig. 5 is a kind of structural schematic diagram of storage medium in the embodiment of the present application.
Specific embodiment
In order to make those skilled in the art more fully understand the technical solution in the embodiment of the present application, below in conjunction with the application
Attached drawing in embodiment, the technical scheme in the embodiment of the application is clearly and completely described, it is clear that described reality
Applying example only is the embodiment of the present application a part of the embodiment, instead of all the embodiments.Based on the implementation in the embodiment of the present application
The range of the embodiment of the present application protection all should belong in example, those of ordinary skill in the art's every other embodiment obtained.
The structure of sensor strip is as shown in Figure 1, blank electrode B, reference electrode R and working electrode in sensor strip
W, three electrodes are arranged successively along sample introduction end, and the electrical contact end of sensor strip is connected with sensor, and sample to be detected is from sensing
The sample introduction end of device strip enters the sample chamber of sensor strip, and sensor will complete the detection of physiological signal.Prior art
In, generally by the impedance value IWB in the circuit that working electrode, blank electrode and the sample in detection sensor strip are constituted,
And IWB is brought into HCT function, HCT value is calculated；Either pass through reference electrode, the blank electricity in detection sensor strip
The impedance value IRB in the circuit that pole and sample are constituted, and IRB is brought into HCT function, HCT value is calculated.No matter but detecting
IWB still detects IRB, and the impedance value in the circuit that different sensors strip and detection sample form all includes in sensor strip
The impedance of electrode itself, and therefore the impedance of electrode itself, is detected because the thickness degree difference of electrode has differences
The accuracy of HCT value will reduce.
The low problem of the HCT value accuracy detected based on prior art, as shown in Fig. 2, the embodiment of the present application provides
A method of detection hematocrit value, including step S100~S300, specifically:
S100: according to the impedance value in the circuit that working electrode, blank electrode and sample to be detected are constituted in sensor strip
The impedance value IRB in the circuit that IWB and reference electrode, blank electrode and sample to be detected are constituted, obtains the impedance of IWB and IRB
Difference DELTA I.
For sensor strip, the impedance IW of working electrode itself, the impedance IB of blank electrode itself and work
The sum of impedance IS1 of sample to be detected between electrode and blank electrode, i.e. IW+IB+IS1 are the electricity that works in sensor strip
The impedance IWB in the circuit that pole, blank electrode and sample to be detected are constituted；Equally, the impedance IR of reference electrode itself, blank electrode
The impedance IB of itself, along with the impedance IS2 of the sample to be detected between reference electrode and blank electrode, i.e. IR+IB+IS2 is
The impedance value IRB in the circuit that reference electrode, blank electrode and sample to be detected are constituted.
After obtaining IWB and IRB, so that it may obtain the impedance differences Δ I of IWB and IRB.Δ I=(IW+IB+IS1)-(IR
+ IB+IS2)=(IW-IR)+(IS1-IS2), i.e. to be detected sample impedance differences of the impedance differences Δ I between two arrays of electrodes and
The impedance differences of working electrode IW and reference electrode IR.
Optionally, the length of reference electrode is more than or equal to working electrode, from fig. 1, it can be seen that the length of reference electrode is greater than
Working electrode, the impedance IR of reference electrode is greater than the impedance IW of working electrode in theory.But on the one hand, sensor examination
The size of item itself is just very small, and the length of general list branch sensor strip is probably 3 centimetres, and working electrode and reference electrode
Length difference probably within 3 millimeters, i.e., the difference of the length of working electrode and reference electrode is relative to single branch sensor strip
The length of itself can be ignored；On the other hand, since the electric conductivity of carbon electrode is preferable, impedance itself is also relatively small, adds
The same sensor strip on working electrode and reference electrode thickness it is also essentially identical, therefore the impedance IW of working electrode
Be believed that with the impedance IR of reference electrode it is approximately uniform, i.e., it is believed that IW is identical as IR.It can further be seen from figure 1 that reference is electric
Sample areas between pole and blank electrode is less than the sample areas between working electrode and blank electrode, and such IS1 will be big
In IS2, then according to formula Δ I=(IW+IB+IS1)-(IR+IB+IS2)=(IW- of the impedance differences Δ I of IWB and IRB
IR)+(IS1-IS2) hinders it is found that impedance differences Δ I may be considered the sample impedance differences to be detected between two arrays of electrodes
Anti- difference DELTA I=IS1-IS2.
In actual operation, putting in order for electrode may be with different in Fig. 1, therefore reference electrode and blank electrode
Between sample areas be not necessarily smaller than the sample areas between working electrode and blank electrode, i.e. IS1 is not necessarily greater to IS2,
Therefore, in the embodiment of the present application, what impedance differences Δ I took is the absolute value of the difference of IWB and IRB, i.e. impedance differences Δ I=|
IWB-IRB|。
Since the impedance of sample to be detected and the HCT of sample to be detected have functional relation, impedance differences Δ
The HCT of I and sample to be detected also has functional relation.After obtaining impedance differences Δ I, step S200 is executed: according to impedance differences
The experimental data of Δ I and hematocrit value obtain the functional relation of hematocrit value and impedance differences Δ I.
Specifically, it is carried out curve fitting in the embodiment of the present application according to the data of impedance differences Δ I and HCT, HCT can be obtained
Functional relation between impedance differences Δ I.
In actual operation, the experimental data of multipair impedance differences Δ I and HCT can be obtained by many experiments, each group
In data, impedance differences Δ I and HCT are corresponded.
After obtaining the functional relation between HCT and impedance differences Δ I, so that it may step S300 is executed, specifically:
S300: hematocrit value detection is carried out according to the functional relation of hematocrit value and impedance differences Δ I.
The HCT function that curve matching obtains is stored in advance in the sensor of HCT detection, in actual test, sensor is first
Then the IWB and IRB of first detection sensor strip calculate the impedance differences Δ I of IWB and IRB, impedance differences Δ I are updated to
In the HCT function prestored, so that it may calculate the HCT value of accurate sample to be detected.
Compared in prior art, the impedance Value Data of multiple groups HCT value and sensor strip is obtained by experiment, wherein
The impedance value data packet of sensor strip contains the impedance value of the electrode in sensor strip itself, and carries out to this multi-group data
The HCT function that curve matching obtains, the impedance differences Δ I used in the embodiment of the present application only have with the impedance value of sample to be detected
The impedance value of electrode in relationship and sensor strip itself is unrelated, therefore, impedance differences Δ I is used in the embodiment of the present application
With HCT carry out curve fitting acquisition HCT function and the correlation of actual hematocrit value it is higher, compared to prior art,
Improve the accuracy of HCT detection.
It is examined in the embodiment of the present application in order to verify the HCT function for using impedance differences Δ I and HCT to carry out curve fitting acquisition
The effect for surveying HCT value, has selected the mutually different 7 kinds of samples to be detected of HCT, and have chosen with a batch of sensor strip,
The sample of every kind of HCT value is tested, and in order to reduce the human error in test process, the sample of every kind of HCT value
Test 6 times, and the IWB and IRB tested every time is recorded, 6 average impedance differences are then calculated as impedance differences Δ I.
The HCT function for taking IWB and HCT to carry out curve fitting according to prior art is as shown in Figure 3A, according to existing skill
The HCT function that art goes IRB and HCT to carry out curve fitting is as shown in Figure 3B.According to 6 average resistances in above-described embodiment
The HCT function that anti-difference DELTA I and HCT carries out curve fitting is as shown in Figure 3 C, and obtained HCT function is as shown in table 2.
The HCT value that each IWB of the every kind of sample HCT function substituted into Fig. 3 A obtains is denoted as HCT1, and it is actual
The deviation of HCT value is denoted as BIAS1；The each IRB of every kind of sample is substituted into the HCT value that HCT function shown in Fig. 3 B obtains to be denoted as
HCT2, and the deviation of actual HCT value are denoted as BIAS2；The each impedance differences Δ I of every kind of sample is substituted into the HCT of Fig. 3 C
The HCT value that function obtains is HCT3, and the deviation of actual HCT value is denoted as BIAS3.It should be noted that deviation BIAS1,
BIAS2 and BIAS3 be actual HCT value with by Fig. 3 A, between the HCT value that function shown in Fig. 3 B and Fig. 3 C calculates
The absolute value of difference.Actual HCT value, every kind of sample to be detected each IWB, IRB and Δ I, HCT1, HCT2, HCT3,
The specific data of BIAS1, BIAS2 and BIAS3 see the table below 1:
17 kinds of samples to be detected of table respectively detect 6 test results
The fitting function table of table 2 IWB, IRB and Δ I and HCT
| No | Curve matching object | Iunction for curve | Related coefficient |
| 1 | IWB&HCT | Y=1.8471X-12.923 | 0.9876 |
| 2 | IRB&HCT | Y=2.7682X-18.367 | 0.9716 |
| 3 | ΔI&HCT | Y=5.4263X-1.061 | 0.9967 |
It is less than BIAS1 and BIAS2 in BIAS3 overwhelming majority situation it can be seen from the data in table 1, even if having
BIAS3 is greater than the case where BIAS1 and BIAS2, and very close with BIAS1 and BIAS2.In some cases, BIAS3 is remote
Much smaller than BIAS1 and BIAS2.The data of table 1 can absolutely prove that the parameter using impedance differences Δ I as HCT function can
To improve the accuracy for the HCT value calculated.
From Table 2, it can be seen that the related coefficient for the HCT function that impedance differences Δ I and HCT curve matching obtains is maximum.
As can be seen from the above embodiments, compared with the prior art, the method that HCT is detected in the embodiment of the present application, using IWB and
Impedance differences and HCT between IRB carry out curve fitting, and the function as HCT carries out HCT detection, can eliminate sensor examination
Influence of the electrode because of manufacturing process to electrode impedance itself on item improves the accuracy of HCT detection.
Based on same inventive concept, as shown in figure 4, the embodiment of the present application also provides a kind of detection hematocrit values
Device, including electrode detection module 401, impedance differences module 402, functional relation module 403 and detection module 404, in which:
Electrode detection module 401 and impedance differences module 402 connect, for working electrode, sky in detection sensor strip
The impedance value IWB and reference electrode, blank electrode and sample to be detected in the circuit that white appliances pole and sample to be detected are constituted are constituted
Circuit impedance value IRB, and the IWB and IRB that will test are sent to impedance differences module 402；
Impedance differences module 402 and the connection of electrode detection module 401 and functional relation module 403, are used for basis from electricity
The IWB and IRB that pole detection module 401 obtains obtain the impedance differences Δ I of IWB and IRB, and obtained impedance differences Δ I are sent out
Give functional relation module 403；
Functional relation module 403 and impedance differences module 402 and detection module 404 connect, and are used for basis from impedance contrast
It is worth the experimental data of impedance differences Δ I and hematocrit value obtained in module 402, obtains hematocrit value and impedance differences Δ
The functional relation of I, and obtained functional relation is sent to detection module 404；
Detection module 404 and functional relation module 403 connect, for red according to obtained in from functional relation module 403
The relationship of specific volume of cell and impedance differences Δ I carry out hematocrit value detection.
Electrode detection module 401, impedance differences module 402, functional relation module 403 and detection module 404 are for executing
The method of hematocrit value is detected described in above-described embodiment.
The embodiment of the present application also provides a kind of storage medium, the program including storage, wherein described program is held when running
The method of hematocrit value is detected described in row above-described embodiment.
The embodiment of the present application also provides a kind of electronic devices, as shown in figure 5, electronic device 50 includes memory 502, place
It manages device 501 and is stored in the computer program that can be run on the memory 502 and on the processor 501, the processing
Device 501 executes the method that hematocrit value is detected described in above-described embodiment by the computer program.
In one exemplary embodiment, above-mentioned processor 501 is closed according to the function of hematocrit value and impedance differences Δ I
When system carries out hematocrit value detection, and according to the experimental data of impedance differences Δ I and hematocrit value, obtain red blood cell ratio
When holding the functional relation with impedance differences Δ I, impedance differences Δ I used is the absolute value of the difference of IWB and IRB | IWB-IRB
|。
In one exemplary embodiment, the length of the reference electrode in above-mentioned processor 501 sensor strip detected
More than or equal to working electrode.
Electronic device provided by the embodiments of the present application can be a terminal device, which can be intelligent hand
Machine, tablet computer etc., the terminal device is for executing detection red blood cell described in the corresponding embodiment of above-mentioned FIG. 1 to FIG. 5
The method of specific volume.
Terminal device may include following one or more components: processing component, memory, power supply module, multimedia group
Part, audio component, the interface of input/output (I/O), sensor module and communication component.
The integrated operation of the usual controlling terminal equipment of processing component, such as with display, telephone call, data communication, camera
Operation and record operate associated operation.Processing component may include one or more processors to execute instruction, to complete
The all or part of the steps of above-mentioned method.In addition, processing component may include one or more modules, convenient for processing component and
Interaction between other assemblies.For example, processing component may include multi-media module, to facilitate multimedia component and processing component
Between interaction.
Memory is configured as storing various types of data to support the operation in terminal device.The example of these data
Instruction including any application or method for operating on the terminal device, contact data, telephone book data disappear
Breath, picture, video etc..Memory can be real by any kind of volatibility or non-volatile memory device or their combination
It is existing, such as static random access memory (full name in English: Static Random Access Memory, English abbreviation: SRAM),
Electrically erasable programmable read-only memory (full name in English: Electrically Erasable Programmable Read
Only Memory, English abbreviation: EEPROM), Erasable Programmable Read Only Memory EPROM (full name in English: Erasable
Programmable Read Only Memory, English abbreviation: EPROM), programmable read only memory (full name in English:
Programmable Read Only Memory, English abbreviation: PROM), read-only memory (full name in English: Read Only
Memory, English abbreviation: ROM), magnetic memory, flash memory, disk or CD.
Power supply module provides electric power for the various assemblies of terminal device.Power supply module may include power-supply management system, and one
A or multiple power supplys and other with for terminal device generate, manage, and distribute the associated component of electric power.
Multimedia component includes the screen of one output interface of offer between terminal device and user.In some implementations
In example, screen may include liquid crystal display (full name in English: Liquid Crystal Display, English abbreviation: LCD) and touching
Touch panel (full name in English: Touch Panel, English abbreviation: TP).If screen includes touch panel, screen can be implemented
For touch screen, to receive input signal from the user.Touch panel include one or more touch sensors with sense touch,
Gesture in sliding and touch panel.Touch sensor can not only sense the boundary of a touch or slide action, but also detect
Duration and pressure relevant to touch or slide.In some embodiments, multimedia component includes one and preposition takes the photograph
As head and/or rear camera.When terminal device is in operation mode, such as in a shooting mode or a video mode, front camera
And/or rear camera can receive external multi-medium data.Each front camera and rear camera can be one
Fixed optical lens system has focusing and optical zoom capabilities.
Audio component is configured as output and/or input audio signal.For example, audio component includes a microphone (English
Literary full name: Microphone, English abbreviation: MIC), when terminal device is in operation mode, as call model, logging mode and
When speech recognition mode, microphone is configured as receiving external audio signal.The received audio signal can be deposited further
Storage is sent in memory or via communication component.In some embodiments, audio component further includes a loudspeaker, for exporting
Audio signal.
I/O interface provides interface between processing component and peripheral interface module, and above-mentioned peripheral interface module can be key
Disk, click wheel, button etc..These buttons may include, but are not limited to: home button, volume button, start button and locking press button.
Sensor module includes one or more sensors, for providing the status assessment of various aspects for terminal device.
For example, sensor module can detecte the state that opens/closes of terminal device, the relative positioning of component, such as component as eventually
The display and keypad of end equipment, the position that sensor module can also detect one component of terminal device or terminal device change
Become, the existence or non-existence that user contacts with terminal device, terminal device orientation or acceleration/deceleration and the temperature of terminal device become
Change.Sensor module may include proximity sensor, be configured to detect object nearby without any physical contact
Presence.Sensor module can also include optical sensor, as complementary metal oxide semiconductor (full name in English:
Complementary Metal Oxide Semiconductor, English abbreviation: CMOS) or charge coupled cell (English is complete
Claim: Charge Coupled Device, English abbreviation: CCD) imaging sensor, for being used in imaging applications.Some
In embodiment, which can also include acceleration transducer, gyro sensor, Magnetic Sensor, pressure sensor
Or temperature sensor.
Communication component is configured to facilitate the communication of wired or wireless way between terminal device and other equipment.Terminal is set
It is standby to access the wireless network based on communication standard, such as Wireless Fidelity (full name in English: Wireless-Fidelity, English letter
Claim: WiFi), 2G or 3G or their combination.In one exemplary embodiment, communication component comes via broadcast channel reception
From the broadcast singal or broadcast related information of external broadcasting management system.In one exemplary embodiment, communication component also wraps
Near-field communication (full name in English: Near Field Communication, English abbreviation: NFC) module is included, to promote short distance logical
Letter.For example, the NFC module can be based on radio frequency identification (full name in English: Radio Frequency Identification, English
Referred to as: RFID) technology, Infrared Data Association's (full name in English: Infrared Data Association, English abbreviation: IrDA)
Technology, ultra wide band (full name in English: Ultra Wideband, English abbreviation: UWB) technology, bluetooth (full name in English:
Bluetooth, English abbreviation: BT) technology and other technologies realize.
In the exemplary embodiment, terminal device can by one or more application specific integrated circuit (full name in English:
Application Specific Integrated Circuit, English abbreviation: ASIC), (English is complete for digital signal processor
Claim: Digital Signal Processing, English abbreviation: DSP), digital signal processing appts (full name in English: Digital
Signal Processing Device, English abbreviation: DSPD), programmable logic device (full name in English: Programmable
Logic Device, English abbreviation: PLD), field programmable gate array (full name in English: Field Programmable Gate
Array, English abbreviation: FPGA), controller, microcontroller, microprocessor or other electronic components realize, it is above-mentioned for executing
The method of hematocrit value is detected described in the corresponding embodiment of FIG. 1 to FIG. 5.
In the exemplary embodiment, a kind of non-transitorycomputer readable storage medium including instruction, example are additionally provided
It such as include the memory of instruction, above-metioned instruction can be executed by the processing component of terminal device to complete the above method.For example, non-face
When property computer readable storage medium can be ROM, random access memory (full name in English: Random Access Memory,
English abbreviation: RAM), CD-ROM, tape, floppy disk and optical data storage devices etc..When the instruction in storage medium is by terminal device
Processing component when executing so as to be able to carry out detection described in the corresponding embodiment of above-mentioned FIG. 1 to FIG. 5 red for terminal device
The method of specific volume of cell, this method comprises:
According to the impedance value IWB in the circuit that working electrode in sensor strip, blank electrode and sample to be detected are constituted, with
And the impedance value IRB in the circuit of reference electrode, blank electrode and sample to be detected composition, obtain the impedance differences Δ of IWB and IRB
I；
According to the experimental data of impedance differences Δ I and hematocrit value, the letter of hematocrit value and impedance differences Δ I is obtained
Number relationship；
Hematocrit value detection is carried out according to the functional relation of hematocrit value and impedance differences Δ I.
Terminal device and storage medium provided by the embodiments of the present application, by establishing hematocrit value and sample to be detected
Impedance between functional relation carry out hematocrit value detection, can reduce because of the carbon electrode thickness journey in sensor strip
Negative effect caused by the inconsistent detection to HCT is spent, the accuracy of HCT detection is improved, and then improves and is made by detection HCT
For the accuracy of the obtained physiological diagnosis result of correction means.
Those skilled in the art will readily occur to its of the disclosure after considering specification and practicing disclosure disclosed herein
Its embodiment.This application is intended to cover any variations, uses, or adaptations of the disclosure, these modifications, purposes or
Person's adaptive change follows the general principles of this disclosure and including the undocumented common knowledge in the art of the disclosure
Or conventional techniques.The description and examples are only to be considered as illustrative, and the true scope and spirit of the disclosure are by following
Claim is pointed out.
It should be understood that the present disclosure is not limited to the precise structures that have been described above and shown in the drawings, and
And various modifications and changes may be made without departing from the scope thereof.The scope of the present disclosure is only limited by the accompanying claims.
In the above-described embodiments, it all emphasizes particularly on different fields to the description of each embodiment, there is no the part for being described in detail or recording in some embodiment,
Reference can be made to the related descriptions of other embodiments.
Claims (10)
1. a kind of method for detecting hematocrit value characterized by comprising
Obtain the impedance value IWB, Yi Jican of working electrode in sensor strip, blank electrode and the constituted circuit of sample to be detected
Than electrode, the impedance value IRB of blank electrode and the constituted circuit of sample to be detected；
According to IWB and IRB, the impedance differences Δ I of IWB and IRB is obtained；
According to the corresponding relationship between the impedance differences Δ I prestored and hematocrit value, hematocrit value is determined.
2. the method for detection hematocrit value according to claim 1, between the impedance differences Δ I and hematocrit value
Corresponding relationship obtaining step are as follows:
According to the experimental data of IWB and IRB, the impedance differences Δ I of the experimental data of IWB and IRB is determined；
It is carried out curve fitting according to the correspondence experimental data of impedance differences Δ I and hematocrit value；
According to curve matching as a result, determining the corresponding relationship between impedance differences Δ I and hematocrit value.
3. the method for detection hematocrit value according to claim 2, which is characterized in that the experimental data of IWB, IRB
Experimental data and the experimental data of hematocrit value are at least three.
4. the method for detection hematocrit value according to claim 2 or 3, which is characterized in that at least three red blood cell ratios
The experimental data of appearance is different.
5. the method for detection hematocrit value according to claim 4, which is characterized in that described according to impedance differences Δ I
Include: before carrying out curve fitting with the correspondence experimental data of hematocrit value
At least three times to the test of each hematocrit value corresponding sensor strip, each IRB and IWB is obtained；
Take at least three times the average value of IRB and at least three times the absolute value of the difference of the average value of IWB as impedance differences Δ I.
6. a kind of device for detecting hematocrit value, which is characterized in that obtain module including the first impedance, the second impedance obtains mould
Block, impedance differences module and hematocrit value module, in which:
First impedance obtains module for obtaining working electrode in sensor strip, blank electrode and sample institute to be detected structure
At the impedance value IWB in circuit；
Second impedance obtains the impedance that module is used to obtain reference electrode, blank electrode and the constituted circuit of sample to be detected
Value IRB；
The impedance differences module is used to obtain the impedance differences Δ I of IWB and IRB according to IWB and IRB；
The hematocrit value module is used for according to the corresponding relationship between the impedance differences Δ I prestored and hematocrit value, really
Determine hematocrit value.
7. the device of detection hematocrit value according to claim 6, which is characterized in that described device further includes impedance contrast
It is worth corresponding relationship between Δ I and hematocrit value and obtains module, is used for:
According to the experimental data of IWB and IRB, the impedance differences Δ I of the experimental data of IWB and IRB is determined；
It is carried out curve fitting according to the correspondence experimental data of impedance differences Δ I and hematocrit value；
According to curve matching as a result, determining the corresponding relationship between impedance differences Δ I and hematocrit value.
8. detecting the device of hematocrit value according to claim 7, which is characterized in that the impedance differences Δ I and red thin
It is used when corresponding relationship acquisition module determines the corresponding relationship between impedance differences Δ I and hematocrit value between born of the same parents' specific volume
The experimental data of the experimental data of IWB, the experimental data of IRB and hematocrit value is at least three.
9. the device of detection hematocrit value according to claim 7 or 8, which is characterized in that described at least three is red thin
The experimental data of born of the same parents' specific volume is different.
10. the device of detection hematocrit value according to claim 9, which is characterized in that impedance differences Δ I and red blood cell
Corresponding relationship obtains module before determining the corresponding relationship between impedance differences Δ I and hematocrit value between specific volume, also wraps
It includes:
At least three times to the test of each hematocrit value corresponding sensor strip, each IRB and IWB is obtained；
Take at least three times the average value of IRB and at least three times the absolute value of the difference of the average value of IWB as impedance differences Δ I.
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