CN110198733B - 用于增强痘病毒中转基因的稳定性的组合物和方法 - Google Patents

用于增强痘病毒中转基因的稳定性的组合物和方法 Download PDF

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CN110198733B
CN110198733B CN201780059549.XA CN201780059549A CN110198733B CN 110198733 B CN110198733 B CN 110198733B CN 201780059549 A CN201780059549 A CN 201780059549A CN 110198733 B CN110198733 B CN 110198733B
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nucleic acid
muc1
ser
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CN110198733A (zh
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M·卡拉
瑞安·朗特里
U·迪迈尔
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Bavarian Nordic AS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/86—Viral vectors
    • C12N15/863—Poxviral vectors, e.g. entomopoxvirus
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CN201780059549.XA 2016-09-28 2017-09-28 用于增强痘病毒中转基因的稳定性的组合物和方法 Active CN110198733B (zh)

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US201662401035P 2016-09-28 2016-09-28
US62/401,035 2016-09-28
PCT/EP2017/074693 WO2018060368A2 (en) 2016-09-28 2017-09-28 Compositions and methods for enhancing the stability of transgenes in poxviruses

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CN110198733B true CN110198733B (zh) 2024-04-30

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EP (1) EP3518964A2 (enExample)
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KR (1) KR102605505B1 (enExample)
CN (1) CN110198733B (enExample)
AU (1) AU2017336269B2 (enExample)
CA (1) CA3036799C (enExample)
IL (1) IL265539B (enExample)
RU (1) RU2756534C2 (enExample)
WO (1) WO2018060368A2 (enExample)
ZA (1) ZA201901756B (enExample)

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US20210046130A1 (en) * 2018-01-24 2021-02-18 Virogin Biotech Canada Ltd Recombinant viral vaccines
EP3847246A1 (en) * 2018-09-06 2021-07-14 Bavarian Nordic A/S Storage improved poxvirus compositions
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
EP3988650A4 (en) * 2019-06-21 2022-09-21 Osaka University METHOD OF PRODUCING AN ARTIFICIAL RECOMBINANT RNA VIRUS THAT KEEPS A FOREIGN GENE STABLE
EP4061405A1 (en) 2019-11-18 2022-09-28 Janssen Biotech, Inc. Vaccines based on mutant calr and jak2 and their uses
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022009049A1 (en) 2020-07-06 2022-01-13 Janssen Biotech, Inc. Prostate neoantigens and their uses

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WO2005046614A2 (en) * 2003-11-12 2005-05-26 Therion Biologics Corporation System for treating and preventing breast cancer
WO2005058937A2 (en) * 2003-12-12 2005-06-30 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A human cytotoxic t-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of muc-1
WO2013103658A1 (en) * 2012-01-03 2013-07-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Native and agonist ctl epitopes of the muc1 tumor antigen
WO2015061416A2 (en) * 2013-10-23 2015-04-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use

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US5766598A (en) 1991-03-07 1998-06-16 Virogenetics Corporation Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products
US5744144A (en) 1993-07-30 1998-04-28 University Of Pittsburgh University Patent Committee Policy And Procedures Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
EP0954593A1 (en) 1996-07-25 1999-11-10 Therion Biologics Corporation Recombinant pox virus for immunization against tumor-associated antigens
US6969609B1 (en) 1998-12-09 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Serivces Recombinant vector expressing multiple costimulatory molecules and uses thereof
HU230198B1 (hu) 2000-11-23 2015-10-28 Bavarian Nordic A/S Módosított Vacciniavírus Ankara-variáns
EP1456230A2 (en) 2001-12-04 2004-09-15 Bavarian Nordic A/S Flavivirus ns1 subunit vaccine
GB0212046D0 (en) 2002-05-24 2002-07-03 Glaxo Group Ltd Vaccines
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CA2741724C (en) 2008-11-27 2016-10-04 Bavarian Nordic A/S Promoters for recombinant viral expression
US8394385B2 (en) 2009-03-13 2013-03-12 Bavarian Nordic A/S Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines
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Publication number Priority date Publication date Assignee Title
WO2005046614A2 (en) * 2003-11-12 2005-05-26 Therion Biologics Corporation System for treating and preventing breast cancer
WO2005058937A2 (en) * 2003-12-12 2005-06-30 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A human cytotoxic t-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of muc-1
WO2013103658A1 (en) * 2012-01-03 2013-07-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Native and agonist ctl epitopes of the muc1 tumor antigen
WO2015061416A2 (en) * 2013-10-23 2015-04-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use

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US11654189B2 (en) 2023-05-23
US20200061174A1 (en) 2020-02-27
RU2756534C2 (ru) 2021-10-01
JP2019528755A (ja) 2019-10-17
IL265539B (en) 2022-03-01
KR102605505B1 (ko) 2023-11-22
AU2017336269B2 (en) 2022-06-16
US20210338788A1 (en) 2021-11-04
US11052139B2 (en) 2021-07-06
CA3036799A1 (en) 2018-04-05
EP3518964A2 (en) 2019-08-07
CN110198733A (zh) 2019-09-03
CA3036799C (en) 2025-05-13
AU2017336269A1 (en) 2019-04-11
NZ752275A (en) 2025-07-25
JP7062003B2 (ja) 2022-05-02
WO2018060368A3 (en) 2019-02-07
IL265539A (en) 2019-05-30
KR20190053272A (ko) 2019-05-17
WO2018060368A2 (en) 2018-04-05
RU2019112725A (ru) 2020-10-29
ZA201901756B (en) 2022-07-27
RU2019112725A3 (enExample) 2020-12-09

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