CN110179769A - A kind of micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response - Google Patents
A kind of micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response Download PDFInfo
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- CN110179769A CN110179769A CN201910504851.2A CN201910504851A CN110179769A CN 110179769 A CN110179769 A CN 110179769A CN 201910504851 A CN201910504851 A CN 201910504851A CN 110179769 A CN110179769 A CN 110179769A
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- lesions position
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- immune response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The application belongs to anticancer drug technical field, and in particular to one kind can induce the micro-and nano-particles pharmaceutical carrier of lesions position local immune response.It includes coatings, nano-medicament carrier and chemicals, and chemicals are attached on nano-medicament carrier, and coatings are coated on the outside of nano-medicament carrier and chemicals by self assembly；Coatings are lesions position cell membrane；The application can induce the micro-and nano-particles pharmaceutical carrier of lesions position local immune response that can locally discharge nano-medicament carrier and chemicals by the Information Conduction between lesions position cell, and chemicals are successively transmitted to by the Information Conduction between lesions position cell by the lesion nearby shifted, the local immunity reaction for only inducing lesions position, transfers immune system and targetedly kills cancer cell.
Description
Technical field
The application belongs to anticancer drug technical field, and in particular to one kind can induce lesions position local immune response
Micro-and nano-particles pharmaceutical carrier.
Background technique
Treatment for cancer many places transfer patient is always the difficult point in oncotherapy.Chemotherapeutics often causes to shift
The serious complication of patient, side reaction takes place frequently during treatment, agonizing.Basic reason is since different chemicals may
All more or less has immunotoxicity, for example same chemical substance may cause the immunosupress of body under different conditions
Or Immune-enhancing effect.
Summary of the invention
In view of the above-mentioned problems, this application provides the micro-and nano-particles that one kind can induce lesions position local immune response
Pharmaceutical carrier, to solve the technical problems existing in the prior art.
The present invention is the solution for solving its technical problem and providing are as follows:
A kind of micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response, which is characterized in that this can
It include coatings, nano-medicament carrier and chemical drugs to induce the micro-and nano-particles pharmaceutical carrier of lesions position local immune response
Object, chemicals are attached on nano-medicament carrier, and coatings are coated on nano-medicament carrier and chemicals by self assembly
Outside；Coatings are lesions position cell membrane；The application can induce the micro-and nano-particles of lesions position local immune response
Pharmaceutical carrier can locally be discharged nano-medicament carrier and chemicals by the Information Conduction between lesions position cell,
And chemicals are successively transmitted to by the Information Conduction between lesions position cell by the lesion nearby shifted, only induce disease
The local immunity at stove position is reacted, and is transferred immune system and is targetedly killed cancer cell.
Preferably, in the micro-and nano-particles pharmaceutical carrier disclosed in the present application that can induce lesions position local immune response
In, nano-medicament carrier be nanometer silicon dioxide particle, nanogold particle, nano-Ag particles Huo ?phosphorus nanometer sheet.It is further excellent
Selection of land , ?modification material for modifying the black squama nanometer sheet is additionally provided in phosphorus nanometer sheet.
Preferably, in the micro-and nano-particles pharmaceutical carrier disclosed in the present application that can induce lesions position local immune response
In, modification material FMoc-NH-PEG12-CH2CH2COOH or metal ion or poly-dopamine.
Preferably, in the micro-and nano-particles pharmaceutical carrier disclosed in the present application that can induce lesions position local immune response
In, inert gas is also wrapped in coatings.
Preferably, the micro-and nano-particles pharmaceutical carrier disclosed in the present application that lesions position local immune response can be induced
Partial size is between 200 nanometers to 500 nanometers.
The application beneficial technical effect compared with prior art:
Take lesions position (such as tumour) cell membrane as the coating of the micro-nano granules with immunotoxicity, by from group
The method package of dress carries the surface of medicine micro-nano granules, by a sheepskin, can have tumour cell to be coated for what is recombinated
Wolf pack pinpoints dispensing to lesion at one by way of in-situ injection.It is passed in the information of true tumour cell and bionical tumour cell
It leads in process by the nanoparticle part release of chemicals and load chemicals and with the signal between tumour cell
Drug is successively transmitted to the lesion nearby shifted by conduction, only the local immunity reaction of induced tumor, and transferring immune system has
Pointedly kill cancer cell.Thus, the micro-and nano-particles provided by the present application that lesions position local immune response can be induced
Pharmaceutical carrier can greatly improve the safety that chemicals are treated in body, more by inducing local immunity reaction in focal zone
Mend the deficiencies in the prior art.
Below in conjunction with specification drawings and specific embodiments, technical solution of the present invention and technical effect are carried out clear
Chu is fully described by.
Detailed description of the invention
Fig. 1: the micro-and nano-particles pharmaceutical carrier of lesions position local immune response can be induced in preferred embodiment one
Structural schematic diagram.
Fig. 2: the micro-and nano-particles pharmaceutical carrier of lesions position local immune response can be induced in preferred embodiment two
Structural schematic diagram.
Identifier declaration:
10- coatings, 20- nano-medicament carrier, 30- chemicals, 40- modification material, 50- inert gas.
Specific embodiment
Referring to Fig. 1, the micro- of lesions position local immune response can be induced disclosed in the application preferred embodiment one
It include coatings 10, nano-medicament carrier 20 and chemicals 30, also the present embodiment in nanoparticle pharmaceutical carrier microstructure
Middle Cai Yong ?phosphorus nanometer sheet as nano-medicament carrier 20.Coatings 10 by the way of self assembly Bao Fu ?phosphorus nanometer sheet
That is the outside of nano-medicament carrier 20 and chemicals 30, chemicals 30 adhere to and be enriched in 20 Ye of nano-medicament carrier Ji ?
In phosphorus nanometer sheet.Be also wrapped in coatings 10 50 , of inert gas ?also set up on phosphorus nanometer sheet namely nano-medicament carrier 20
There is modification material 40, modification material 40 is FMoc-NH-PEG12-CH2CH2COOH.Coatings 10 are tumor cell membrane, by tumour
Cell membrane is centrifuged from tumour cell dissolve after again self assembly be aligned to 20 Ye of nano-medicament carrier Ji ?phosphorus nanometer sheet
Surface can form the coatings 10 of the application.
Referring to Fig. 2, the micro- of lesions position local immune response can be induced disclosed in the application preferred embodiment two
It include coatings 10, nano-medicament carrier 20 and chemicals 30 in nanoparticle pharmaceutical carrier microstructure, in the present embodiment
Using nanometer silicon dioxide particle as nano-medicament carrier 20.Coatings 10 are coated on nano-silica by the way of self assembly
The outside of silicon carbide particle namely nano-medicament carrier 20 and chemicals 30, chemicals 30 adhere to and are enriched in Nano medication load
On body 20 namely nanometer silicon dioxide particle.Coatings 10 be cancer cell film, by cancer cell film from cancer cell from
The heart gets off dissolve after again self assembly be aligned to nano-medicament carrier 20 namely the surface of nano silica and can form this Shen
Coatings 10 please.
The wolf pack being coated with tumour cell or cancer cell recombinated is pinpointed dispensing to arrive by way of in-situ injection
Lesion at one.By chemicals and load chemical drugs in the Information Conduction process of true tumour cell and bionical tumour cell
The nanoparticle of object locally discharges and as drug is successively transmitted to the disease nearby shifted by the signal transduction between tumour cell
Stove, only the local immunity reaction of induced tumor, transfers immune system and targetedly kills cancer cell.Thus, the application mentions
The micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response supplied is by inducing local immunity in focal zone
Reaction, can greatly improve the safety that chemicals are treated in body, make up the deficiencies in the prior art.
Figure of description is combined to elaborate preferred embodiment of the present application above, it should explanation, this
The protection scope of application includes but is not limited to above-described embodiment；Specific structure disclosed in Figure of description is also the application
Preferred embodiment；The technical staff in the field can also develop other embodiments on this basis, any not depart from this hair
The simple deformation or equivalent replacement of bright innovative idea, are covered by the application, belong to the protection scope of the application.
Claims (6)
1. the micro-and nano-particles pharmaceutical carrier that one kind can induce lesions position local immune response, which is characterized in that this can be with
Induction lesions position local immune response micro-and nano-particles pharmaceutical carrier include coatings (10), nano-medicament carrier (20) and
Chemicals (30), the chemicals (30) are attached on the nano-medicament carrier (20), and the coatings (10) pass through
Self assembly is coated on the outside of the nano-medicament carrier (20) and the chemicals (30)；The coatings (10) are lesion
Position cell membrane；The micro-and nano-particles pharmaceutical carrier that lesions position local immune response can be induced can by with lesion
Information Conduction between the cell of position locally discharges the nano-medicament carrier (20) and the chemicals (30), and passes through
The chemicals (30) are successively transmitted to the lesion nearby shifted by the Information Conduction between lesions position cell, are only induced
The local immunity of lesions position is reacted, and is transferred immune system and is targetedly killed cancer cell.
2. the micro-and nano-particles pharmaceutical carrier according to claim 1 that lesions position local immune response can be induced,
Be characterized in that: the nano-medicament carrier (20) be nanometer silicon dioxide particle, nanogold particle, nano-Ag particles Huo ?phosphorus receive
Rice piece.
3. the micro-and nano-particles pharmaceutical carrier according to claim 2 that lesions position local immune response can be induced,
Be characterized in that: Suo Shu ?modification material (40) for modifying the black squama nanometer sheet is additionally provided in phosphorus nanometer sheet.
4. the micro-and nano-particles pharmaceutical carrier according to claim 3 that lesions position local immune response can be induced,
Be characterized in that: the modification material is FMoc-NH-PEG12-CH2CH2COOH or metal ion or poly-dopamine.
5. the micro-and nano-particles pharmaceutical carrier according to claim 1 that lesions position local immune response can be induced,
It is characterized in that: being also wrapped on inert gas (50) in the coatings (10).
6. the micro-nano of lesions position local immune response can be induced described in any one of -5 claims according to claim 1
Rice corpuscles pharmaceutical carrier, it is characterised in that: this can induce the micro-and nano-particles pharmaceutical carrier of lesions position local immune response
Partial size between 200 nanometers to 500 nanometers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910504851.2A CN110179769A (en) | 2019-06-11 | 2019-06-11 | A kind of micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910504851.2A CN110179769A (en) | 2019-06-11 | 2019-06-11 | A kind of micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response |
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| Publication Number | Publication Date |
|---|---|
| CN110179769A true CN110179769A (en) | 2019-08-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910504851.2A Pending CN110179769A (en) | 2019-06-11 | 2019-06-11 | A kind of micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103857387A (en) * | 2011-06-02 | 2014-06-11 | 加利福尼亚大学董事会 | Membrane encapsulated nanoparticles and method of use |
| US20150342883A1 (en) * | 2014-05-30 | 2015-12-03 | Drexel University | Hyaluronidase and a Low Density Second PEG Layer on the Surface of Therapeutic-Encapsulated Nanoparticles to Enhance Nanoparticle Diffusion and Circulation |
| CN109078183A (en) * | 2017-06-13 | 2018-12-25 | 天津大学 | A kind of multifunctional bionic nanometer formulation and its preparation method and application based on cancer cell membrane |
| CN109529064A (en) * | 2019-01-04 | 2019-03-29 | 北京大学深圳医院 | The black phosphorus microvesicle pharmaceutical carrier and preparation method thereof of tumor by local fixed point radiotherapy may be implemented |
-
2019
- 2019-06-11 CN CN201910504851.2A patent/CN110179769A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103857387A (en) * | 2011-06-02 | 2014-06-11 | 加利福尼亚大学董事会 | Membrane encapsulated nanoparticles and method of use |
| US20150342883A1 (en) * | 2014-05-30 | 2015-12-03 | Drexel University | Hyaluronidase and a Low Density Second PEG Layer on the Surface of Therapeutic-Encapsulated Nanoparticles to Enhance Nanoparticle Diffusion and Circulation |
| CN109078183A (en) * | 2017-06-13 | 2018-12-25 | 天津大学 | A kind of multifunctional bionic nanometer formulation and its preparation method and application based on cancer cell membrane |
| CN109529064A (en) * | 2019-01-04 | 2019-03-29 | 北京大学深圳医院 | The black phosphorus microvesicle pharmaceutical carrier and preparation method thereof of tumor by local fixed point radiotherapy may be implemented |
Non-Patent Citations (1)
| Title |
|---|
| RONG YANG，等: "Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination", 《ACS NANO》 * |
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Application publication date: 20190830 |