CN109529064A - The black phosphorus microvesicle pharmaceutical carrier and preparation method thereof of tumor by local fixed point radiotherapy may be implemented - Google Patents
The black phosphorus microvesicle pharmaceutical carrier and preparation method thereof of tumor by local fixed point radiotherapy may be implemented Download PDFInfo
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- CN109529064A CN109529064A CN201910015282.5A CN201910015282A CN109529064A CN 109529064 A CN109529064 A CN 109529064A CN 201910015282 A CN201910015282 A CN 201910015282A CN 109529064 A CN109529064 A CN 109529064A
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Abstract
The application belongs to anticancer drug technical field, and in particular to may be implemented tumor by local fixed point radiotherapy phosphorus microvesicle pharmaceutical carrier and preparation method thereof.This may be implemented tumor by local fixed point radiotherapy phosphorus microvesicle pharmaceutical carrier include lipid microbubble and be coated on lipid microbubble Nei phosphorus carrier, radiopharmaceutical and inert gas；Radiopharmaceutical Fu Ji on phosphorus carrier； phosphorus carrier be single layer and/or few layer Na meter phosphorus piece.Preparation method includes drug load step and microvesicle film formation step.It is provided by the present application may be implemented tumor by local fixed point radiotherapy phosphorus microvesicle pharmaceutical carrier there is lesion safe and reliable, easy to reach, active drug dosage to be enough and may be implemented part pinpoint the technical advantages such as enrichment treatment.
Description
Technical field
The application belongs to anticancer drug technical field, and in particular to may be implemented tumor by local fixed point radiotherapy ?phosphorus
Microvesicle pharmaceutical carrier and preparation method thereof.
Background technique
At present there are mainly two types of tumor radiotherapy technologies, one is the putting headed by " fast cutting edge of a knife or a sword knife " for clinically developing to today
The accurate treatment of ray instrument, another kind are still to utilize the other radioactive tracer of micro/nano level in trial in preclinical study
Carrier load radiopharmaceutical is targetedly treated for malignant tumour lesion.
Both there is applied defect.The former is quantified for lesion as three-dimensional orientation by the precision control radioactive ray of instrument
Local irradiation treatment, the difficulty of implementation is how precisely to irradiate the irradiation that normal tissue is avoided in tumor lesion area damage
The irradiation damage that wound, i.e. the former therapeutic modality be easy to cause the normal tissue near lesion.The latter is generally by micro-and nano-particles
It constitutes, since the drug loading property of micro-and nano-particles is poor, portable radiopharmaceutical is difficult to follow by blood first
Ring is enriched in lesions position, and the radiopharmaceutical dosage for secondly reaching lesion is too low, and can be removed quickly, therefore difficult to realize
The fixed point of part is enriched with treatment.
Summary of the invention
In view of this, this application provides it is a kind of may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle drug carry
Body and preparation method thereof, to solve the technical problems existing in the prior art.
The application is the technical solution for solving its technical problem and using are as follows:
A kind of ?phosphorus microvesicle pharmaceutical carrier that tumor by local fixed point radiotherapy may be implemented, it is characterised in that: this can be with
Realize tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier include lipid microbubble and be coated in lipid microbubble
?phosphorus carrier, radiopharmaceutical and inert gas；Radiopharmaceutical Fu Ji ?on phosphorus carrier；?phosphorus carrier be single layer and/or
The Na meter of few layer ?phosphorus piece；The partial size of lipid microbubble is between 2 microns to 5 microns.
Further, it is provided by the present application may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier
In, radiopharmaceutical can be various common emissivity drugs in the prior art.Preferably, it can be99mTcN-NOET、99mTc-MIBI、99mTc-tetrofosmin、99mTc-furifosmin and99mIn Tc-teboroxime any one or at least
Any combination of two of them.
Further, it is provided by the present application may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier
In, lipid microbubble is SonoVue microvesicle, Optison microvesicle or Definity microvesicle.
Further, it is provided by the present application may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier
In, may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier further include for Xiu Shi ?phosphorus carrier modification
Substance.Preferably, modification material FMoc-NH-PEG12-CH2CH2COOH or metal ion or poly-dopamine.
Further, it is provided by the present application may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier
In, inert gas is perfluoropropane gas or SF6Gas or other medical inert gases.
The another aspect of the application, also disclose it is a kind of may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle medicine
The preparation method of object carrier, this method comprises:
Drug load step , Ba ?phosphorus aqueous solution injection radiopharmaceutical ampulla in and be uniformly mixed, then extract mixing
Liquid , Qi Zhong ?phosphorus aqueous solution Zhong ?phosphorus be single layer and/or few layer Na meter ?phosphorus piece；
Microvesicle film formation step is filled in the mixed liquor formed in drug load step injection lipid microbubble preparation ampulla
Inert gas is shaken by the way of sonic oscillation and/or mechanical shearing and/or is sheared to blistering, obtains the dispersion of grey black
Lotion, the microvesicle partial size in dispersion emulsion are coated with inert gas between 2 microns to 5 microns and inside microvesicle.
Further, it is provided by the present application may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier
Preparation method in, radiopharmaceutical is99mTcN-NOET、99mTc-MIBI、99mTc-tetrofosmin、99mTc-
Furifosmin and99mAny one in Tc-teboroxime or two kinds any combination at least within.
Further, it is provided by the present application may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier
Preparation method in, it is that medical SonoVue microvesicle prepares ampulla that lipid microbubble, which prepares ampulla, and the microvesicle formed in dispersion emulsion is
SonoVue microvesicle.
Further, it is provided by the present application may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier
Preparation method in, a meter ?phosphorus piece of receiving also have passed through modifying interface, and stability is strengthened, modifying interface mode be with lower bound
At least one of face modification mode or any combination thereof: organic coating modification, chemical coordination modification, covalent modification, ion are mixed
Miscellaneous modification, defect repair modification.Preferably, Na meter ?phosphorus piece have passed through FMoc-NH-PEG12-CH2CH2COOH modification or metal
Ion modification or poly-dopamine modification or fluorescence covalent modification.
The application beneficial technical effect compared with prior art:
It, can be at any time in human body since nanometer black phosphorus piece is a kind of stratiform two-dimensional material with abundant specific surface area
Passage slowly degradation.Black phosphorus is bigger than conventional nano liposome charging ratio for containing for broad-spectrum anti-cancer drug such as Doxorubicin
200 times, enrichment of the radiopharmaceutical on carrier can be dramatically increased.Medicine black phosphorus will be carried to contain with phospholipid microbubble, one side of microvesicle
Inert gas such as SF of the face as the enrichment carrier for carrying medicine black phosphorus, in another aspect microvesicle6The letter of ultrasound diagnosis can be improved
It makes an uproar ratio.One of the characteristics of microvesicle be exactly can be tracked under ultrasonic monitoring, once ultrasonography follow to load radiopharmaceutical ratio
Such as99mThe black phosphorus microvesicle of TcN-NOET is transported by blood circulation to after tumor lesion area, can by adjust ultrasound intensity so that
Microvesicle is carried in tumor focus explosion, release99mThe black phosphorus of TcN-NOET radiopharmaceutical.Since ultrasound fixed point blasting technique can be with
Moment open cells film, so that the black phosphorus for carrying radiopharmaceutical enters cancer cell, so that the fixed point realized for cancer cell is controlled
It treats.It follows that the application Ti Gong ?phosphorus microvesicle pharmaceutical carrier have lesion safe and reliable, easy to reach, radiopharmaceutical
Dosage foot and may be implemented part pinpoint enrichment treatment etc. technical advantages.
To keep technical solution and the technical effect of the application clearer, clear, below in conjunction with Figure of description and specifically
Embodiment to this application Gong Kai ?phosphorus microvesicle pharmaceutical carrier and preparation method thereof be described in detail.
Detailed description of the invention
Fig. 1: ?phosphorus microvesicle pharmaceutical carrier structural schematic diagram.
Identifier declaration:
10- lipid ultrasonic microvesicle, 20- ?phosphorus carrier, 30- radiopharmaceutical, 40- inert gas, 50- modification material.
Specific embodiment
Referring to Fig. 1, provided in the application preferred embodiment may be implemented tumor by local fixed point radiotherapy ?phosphorus
In microvesicle pharmaceutical carrier structure include lipid ultrasonic microvesicle 10 and be coated on 10 Nei of lipid ultrasonic microvesicle ?phosphorus carrier 20, put
Penetrating property drug 30, inert gas 40 and modification material 50；The carrying of radiopharmaceutical 30 or Fu Ji ?on phosphorus carrier 20.Lipid is super
Sound microvesicle 10 be preferably SonoVue microvesicle , ?phosphorus carrier 20 be single layer and/or few layer Na meter ?phosphorus piece, emissivity drug 30
For99mTcN-NOET、99mTc-MIBI、99mTc-tetrofosmin、99mTc-furifosmin and99mIn Tc-teboroxime
Any one or two kinds any combination at least within.The partial size of lipid microbubble 10 is between 2 microns to 5 microns.Modifier
Matter 50 is changed because of the modifying interface mode taken in different embodiments, preferably FMoc-NH-PEG12-CH2CH2COOH
Modification or Metal Ions Modification or poly-dopamine modification.
Specific embodiment one
Drug load step, by FMoc-NH-PEG12-CH2CH2COOH modify ?phosphorus aqueous solution injection it is medical99mIn TcN-NOET ampulla and be uniformly mixed, then extract out finely dispersed Qi Zhong of mixed liquor , ?phosphorus aqueous solution Zhong ?phosphorus be
The Na meter of single layer and/or few layer ?phosphorus piece, partial size is between 500 nanometers to 5 microns；
Microvesicle film formation step is filled in the mixed liquor formed in drug load step injection SonoVue microvesicle preparation ampulla
Enter SF6Gas is successively shaken by the way of sonic oscillation and mechanical stirring shearing and stirs shearing to blistering, obtains grey black
Dispersion emulsion, the microbubble concentration in dispersion emulsion is about 3.0 × 109A/ml.Microvesicle partial size in lotion is between 2 microns to 5
Between micron, and SF is coated with inside microvesicle6Gas.
Specific embodiment two
Drug load step, by fluorescence covalent modification ?phosphorus aqueous solution injection it is medical99mIn TcN-NOET ampulla simultaneously
Be uniformly mixed, then extract out finely dispersed Qi Zhong of mixed liquor , ?phosphorus aqueous solution Zhong ?phosphorus be single layer and/or few layer nanometer
?phosphorus piece, partial size is between 200 nanometers to 4 microns；
Microvesicle film formation step prepares the mixed liquor formed in drug load step injection mixed phosphatide microvesicle in ampulla,
It is filled with perfluoropropane gas, successively shaken by the way of sonic oscillation and mechanical stirring shearing and stirs shearing to blistering, is obtained
To the dispersion emulsion of grey black, the microbubble concentration in dispersion emulsion is about 3.2 × 109A/ml.Microvesicle partial size in lotion between
Between 2 microns to 4 microns, and perfluoropropane gas is coated with inside microvesicle.
Specific embodiment three
Drug load step, by poly-dopamine modification ?phosphorus aqueous solution injection it is medical99mIn TcN-NOET ampulla simultaneously
Be uniformly mixed, then extract out finely dispersed Qi Zhong of mixed liquor , ?phosphorus aqueous solution Zhong ?phosphorus be single layer and/or few layer nanometer
?phosphorus piece, partial size is between 200 nanometers to 5 microns；
Microvesicle film formation step is filled in the mixed liquor formed in drug load step injection SonoVue microvesicle preparation ampulla
Enter SF6Gas is successively shaken by the way of sonic oscillation and mechanical stirring shearing and stirs shearing to blistering, obtains grey black
Dispersion emulsion, the microbubble concentration in dispersion emulsion is about 3.3 × 109A/ml.Microvesicle partial size in lotion is between 2 microns to 5
Between micron, and SF is coated with inside microvesicle6Gas.
Specific embodiment four
Drug load step, do not modified ?phosphorus aqueous solution injection it is medical99mIn TcN-NOET ampulla and mix equal
It is even, then extract out finely dispersed Qi Zhong of mixed liquor , ?phosphorus aqueous solution Zhong ?phosphorus be single layer and/or few layer Na meter ?phosphorus
Piece, partial size is between 200 nanometers to 5 microns；
Microvesicle film formation step is filled in the mixed liquor formed in drug load step injection SonoVue microvesicle preparation ampulla
Enter SF6Gas is shaken by the way of sonic oscillation or mechanical stirring shearing or stirs shearing to blistering, obtains point of grey black
Lotion is dissipated, the microbubble concentration in dispersion emulsion is about 3.1 × 109A/ml.Microvesicle partial size in lotion is between 2 microns to 5 microns
Between, and SF is coated with inside microvesicle6Gas.
It, can be at any time in human body since nanometer black phosphorus piece is a kind of stratiform two-dimensional material with abundant specific surface area
It elapses and slowly degrades.Black phosphorus is bigger than conventional nano liposome charging ratio for containing for broad-spectrum anti-cancer drug such as Doxorubicin
200 times, enrichment of the radiopharmaceutical on carrier can be dramatically increased.Medicine black phosphorus will be carried to contain with phospholipid microbubble, one side of microvesicle
Inert gas such as SF of the face as the enrichment carrier for carrying medicine black phosphorus, in another aspect microvesicle6The letter of ultrasound diagnosis can be improved
It makes an uproar ratio.One of the characteristics of microvesicle be exactly can be tracked under ultrasonic monitoring, once ultrasonography follow to load radiopharmaceutical ratio
Such as99mThe black phosphorus microvesicle of TcN-NOET is transported by blood circulation to after tumor lesion area, can by adjust ultrasound intensity so that
Microvesicle is carried in tumor focus explosion, release99mThe black phosphorus of TcN-NOET radiopharmaceutical.Since ultrasound fixed point blasting technique can be with
Moment open cells film, so that the black phosphorus for carrying radiopharmaceutical enters cancer cell, so that the fixed point realized for cancer cell is controlled
It treats.It follows that the application Ti Gong ?phosphorus microvesicle pharmaceutical carrier have lesion safe and reliable, easy to reach, radiopharmaceutical
Dosage foot and may be implemented part pinpoint enrichment treatment etc. technical advantages.
Figure of description is combined to elaborate preferred embodiment of the present application above, it should explanation, this
The protection scope of application includes but is not limited to above-described embodiment；Specific structure disclosed in Figure of description is also the application
Better embodiment, the technical staff in the field can also develop other embodiments on this basis, any not take off
Simple deformation or equivalent replacement from the application innovative idea, are covered by the application, belong to the protection scope of the application.
Claims (10)
1. may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier, it is characterised in that: this may be implemented to swell
The black phosphorus microvesicle pharmaceutical carrier of the local fixed point radiotherapy of tumor includes lipid microbubble (10) and is coated on the lipid microbubble
(10) black phosphorus carrier (20), radiopharmaceutical (30) and inert gas (40) in；The radiopharmaceutical (30) is enriched in institute
It states on black phosphorus carrier (20)；The black phosphorus carrier (20) is the nanometer black phosphorus piece of single layer and/or few layer；The lipid microbubble (10)
Partial size between 2 microns to 5 microns.
2. the black phosphorus microvesicle pharmaceutical carrier according to claim 1 that tumor by local fixed point radiotherapy may be implemented, special
Sign is: the radiopharmaceutical (30) is99mTcN-NOET、99mTc-MIBI、99mTc-tetrofosmin、99mTc-
Furifosmin and99mAny one in Tc-teboroxime or two kinds any combination at least within.
3. the black phosphorus microvesicle pharmaceutical carrier according to claim 1 that tumor by local fixed point radiotherapy may be implemented, special
Sign is: the lipid microbubble (10) is SonoVue microvesicle, Optison microvesicle or Definity microvesicle.
4. it is according to claim 1 may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier, it is special
Sign is: it is described may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier further include for modifying Shu ?
The modification material (50) of phosphorus carrier (20).
5. the black phosphorus microvesicle pharmaceutical carrier according to claim 4 that tumor by local fixed point radiotherapy may be implemented, special
Sign is: the modification material (50) is FMoc-NH-PEG12-CH2CH2COOH or metal ion or poly-dopamine.
6. the black phosphorus microvesicle pharmaceutical carrier according to claim 1 that tumor by local fixed point radiotherapy may be implemented, special
Sign is: the inert gas (40) is perfluoropropane gas or SF6Gas.
7. the preparation method of the black phosphorus microvesicle pharmaceutical carrier of tumor by local fixed point radiotherapy may be implemented, comprising:
Drug load step injects black phosphorus aqueous solution in radiopharmaceutical ampulla and is uniformly mixed, then extracts mixed liquor,
Black phosphorus in middle black phosphorus aqueous solution is the nanometer black phosphorus piece of single layer and/or few layer；
Microvesicle film formation step is filled with inertia in the mixed liquor formed in drug load step injection lipid microbubble preparation ampulla
Gas is shaken by the way of sonic oscillation and/or mechanical shearing and/or is sheared to blistering, obtains the dispersion emulsion of grey black,
Microvesicle partial size in dispersion emulsion is coated with inert gas between 2 microns to 5 microns and inside microvesicle.
8. it is according to claim 7 may be implemented tumor by local fixed point radiotherapy ?phosphorus microvesicle pharmaceutical carrier preparation
Method, it is characterised in that: the radiopharmaceutical is99mTcN-NOET、99mTc-MIBI、99mTc-tetrofosmin、99mTc-
Furifosmin and99mAny one in Tc-teboroxime or two kinds any combination at least within；The lipid microbubble
Preparing ampulla is that medical SonoVue microvesicle prepares ampulla, and the microvesicle in dispersion emulsion is SonoVue microvesicle.
9. the preparation of the black phosphorus microvesicle pharmaceutical carrier according to claim 7 that tumor by local fixed point radiotherapy may be implemented
Method, it is characterised in that: the nanometer black phosphorus piece also have passed through modifying interface, and stability is strengthened, modifying interface mode
For at least one of following modifying interface mode or any combination thereof: organic coating is modified, chemical coordination is modified, is covalently repaired
Decorations, ion doping modification, defect repair modification.
10. the system of the black phosphorus microvesicle pharmaceutical carrier according to claim 9 that tumor by local fixed point radiotherapy may be implemented
Preparation Method, it is characterised in that: the nanometer black phosphorus piece have passed through FMoc-NH-PEG12-CH2CH2COOH modification or metal ion are repaired
Decorations or poly-dopamine modification or fluorescence covalent modification.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179769A (en) * | 2019-06-11 | 2019-08-30 | 北京大学深圳医院 | A kind of micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response |
| WO2021087945A1 (en) * | 2019-11-07 | 2021-05-14 | 青岛大学 | Method for preparing bifunctional hybrid film for tumor exosome self-calibration detection |
| CN113134083A (en) * | 2021-03-09 | 2021-07-20 | 深圳市人民医院(深圳市呼吸疾病研究所) | Sound sensitive agent and application thereof |
| CN113456838A (en) * | 2021-02-09 | 2021-10-01 | 深圳市人民医院 | Magnetic black phosphorus microvesicle and application thereof in preparing ultrasonic diagnostic reagent and medicine for treating breast cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107252416A (en) * | 2017-05-08 | 2017-10-17 | 上海大学 | Method for preparing lipidosome of the one kind containing irradiation graphene quantum dot (IGQDs) |
| CN108373145A (en) * | 2018-05-15 | 2018-08-07 | 中国科学院深圳先进技术研究院 | A kind of black phosphorus and its preparation method and application of poly-dopamine modification |
-
2019
- 2019-01-04 CN CN201910015282.5A patent/CN109529064A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107252416A (en) * | 2017-05-08 | 2017-10-17 | 上海大学 | Method for preparing lipidosome of the one kind containing irradiation graphene quantum dot (IGQDs) |
| CN108373145A (en) * | 2018-05-15 | 2018-08-07 | 中国科学院深圳先进技术研究院 | A kind of black phosphorus and its preparation method and application of poly-dopamine modification |
Non-Patent Citations (4)
| Title |
|---|
| RAJ KUMAR THAPA等: ""PEGylated lipid bilayer-wrapped nano-graphene oxides for synergistic co-delivery of doxorubicin and rapamycin to prevent drug resistance in cancers"", 《NANOTECHNOLOGY》 * |
| SAMIRA TAJVAR等: ""Preparation of liposomal doxorubicin-graphene nanosheet and evaluation of its in vitro anti-cancer effects"", 《JOURNAL OF LIPOSOME RESEARCH》 * |
| 彭晓艳等: ""C3F8脂质体超声微泡造影剂制备的初步研究"", 《武汉大学学报（医学版）》 * |
| 盘捷: ""载药聚乳酸微泡超声造影剂的实验研究"", 《厦门大学硕士学位论文》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179769A (en) * | 2019-06-11 | 2019-08-30 | 北京大学深圳医院 | A kind of micro-and nano-particles pharmaceutical carrier that can induce lesions position local immune response |
| WO2021087945A1 (en) * | 2019-11-07 | 2021-05-14 | 青岛大学 | Method for preparing bifunctional hybrid film for tumor exosome self-calibration detection |
| US11105767B1 (en) | 2019-11-07 | 2021-08-31 | Qingdao University | Method for preparing dual-functional hybrid thin-film for self-calibration detection of tumor-derived exosomes |
| CN113456838A (en) * | 2021-02-09 | 2021-10-01 | 深圳市人民医院 | Magnetic black phosphorus microvesicle and application thereof in preparing ultrasonic diagnostic reagent and medicine for treating breast cancer |
| CN113456838B (en) * | 2021-02-09 | 2023-05-09 | 深圳市人民医院 | Magnetic black phosphorus microbubbles and application thereof in preparation of ultrasonic diagnostic reagent and breast cancer treatment drug |
| CN113134083A (en) * | 2021-03-09 | 2021-07-20 | 深圳市人民医院(深圳市呼吸疾病研究所) | Sound sensitive agent and application thereof |
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