CN110167572A - Black raspberry extract, the cataract prevention containing black raspberry extract or progression inhibiting agent and diet product, the manufacturing method of black raspberry extract and used black raspberry extract cataract prevention method or its progression inhibiting method - Google Patents
Black raspberry extract, the cataract prevention containing black raspberry extract or progression inhibiting agent and diet product, the manufacturing method of black raspberry extract and used black raspberry extract cataract prevention method or its progression inhibiting method Download PDFInfo
- Publication number
- CN110167572A CN110167572A CN201880004844.XA CN201880004844A CN110167572A CN 110167572 A CN110167572 A CN 110167572A CN 201880004844 A CN201880004844 A CN 201880004844A CN 110167572 A CN110167572 A CN 110167572A
- Authority
- CN
- China
- Prior art keywords
- black raspberry
- raspberry extract
- extract
- black
- cataract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The expression of black raspberry extract induction alpha-crystal albumen of the invention.
Description
Technical field
The present invention relates to black raspberry extract, the prevention of the cataract containing black raspberry extract or progression inhibiting agent and diet
Product, black raspberry extract manufacturing method and used black raspberry extract cataract prevention method or its progression inhibiting side
Method.
Background technique
For most of biology, oxygen be it is integral, a few percent being ingested to intracorporal oxygen becomes activity
Oxygen, for host defense against bacterial infection etc..But in order to maintain homeostasis, remaining activity oxygen demand is intracorporal anti-by biology
External source antioxidant in oxidizing ferment, food removes.
In addition, because ultraviolet light, smoking, exhaust gas, atmosphere pollution, stress wait generate excessive active oxygen when, give organism group
Ribbon comes oxidative damage (for example, see non-patent literature 1).As a result, cause be with life style disease, geriatric disease
Cancer, dementia of representative etc., it may be said that the active oxygen of 90% or more disease and excess generation there are causality (for example, see
Non-patent literature 2).
Therefore, in the activation of intracorporal superoxide dismutase (SOD, Superoxide dismutase) and food
Antioxidant attracts attention, and establishes the measuring method (ORAC of the oxidation resistance by agriculture business portion, the U.S. (USDA) exploitation；
Oxygen Radical Absorbance Capacity, oxygen radical absorbability), it is gaining popularity (for example, see non-special
Sharp document 3).In addition, in the high food of ORAC value, the i.e. high food of oxidation resistance best 100, there are the certain kind of berries of 12 kinds
Based food (for example, see non-patent literature 4).
In addition, an example as geriatric disease, can enumerate cataract.Cataract is sent out because muddiness occurs for crystalline lens
Disease, but it is unclear why the lenticular transparency can be lost and become muddy.The maintenance of the lenticular transparency and crystalline substance
The ordered structure that shape body constitutes protein is related.When constituting crystalline protein (Crystallin) agglutination of protein as it, out
The muddiness for now reducing lenticular lens function, affects to the visual field, eyesight (for example, see non-patent literature 5).In addition,
In crystalline protein, discovery alpha-crystal albumen has the function of inhibiting the agglutination of crystalline protein to combine.
It may be said that the crystallins of eyes be it is irreplaceable throughout one's life, in order not to because it is insoluble lead to muddiness due to make α-
Crystalline protein re-starts gene expression to supply for crystalline lens be useful.
Existing technical literature
Non-patent literature
Non-patent literature 1:Oberdanner, C.ROS and Antioxidant Systems in Apoptosis.VDM
Verlag,2008.ISBN 978-3836482110
Non-patent literature 2:Slavin JL et al.Health benefits of fruits and
vegetables.Adv Nutr.2012.1；3 (4): 506-516
Non-patent literature 3:Cao G et al.Oxygen-radical absorbance capacity assay for
Antioxidants.Free Radical Biol.Med.1993.14:303-311
Non-patent literature 4: " high best 100 list of (antioxidation is high) food of ORAC value " [online (online)]
(retrieval on June 30th, 2017) http://www.anteaoxidant.com/orac#top100.html
Non-patent literature 5:Alan R.Hipkiss, Accumulation of altered proteins and
41 (2006) 464-473 of ageing:Causes and effects Experimental Gerontology
Summary of the invention
Problem to be solved by the invention
The object of the present invention is to provide have the function of prevention or inhibit its be in progress certain kind of berries class extract,
The manufacturing method of the extract of the cataract prevention or progression inhibiting agent and diet product and certain kind of berries class of extract containing the certain kind of berries class.
In addition, the object of the present invention is to provide the prevention method of the cataract for the extract for having used certain kind of berries class or its progression inhibiting sides
Method.
The present inventor is conceived to the certain kind of berries based food as the food with antioxidation, to certain kind of berries based food and as old age
Property disease cataract prevention or the correlation of effect that inhibits it to be in progress studied, as a result, it has been found that black raspberry mentions
Object is taken to reach above-mentioned purpose, so as to complete the present invention.
The method for solving problem
That is, according to the present invention, it is possible to provide:
(1) a kind of black raspberry extract induces the expression of alpha-crystal albumen；
(2) a kind of cataract prevention or progression inhibiting agent, contain black raspberry extract described in (1)；
(3) a kind of diet product contains black raspberry extract described in (1)；
(4) a kind of manufacturing method of black raspberry extract is the manufacturing method of black raspberry extract described in (1),
It include: the freezing process freezed to the fruit of black raspberry；The defrosting process thawed to the fruit of above-mentioned black raspberry；To
The agitating procedure for adding solvent in the fruit of above-mentioned black raspberry after thawing using above-mentioned defrosting process and being stirred；With will lead to
The abstraction process that the fruit and solvent of above-mentioned black raspberry after crossing above-mentioned agitating procedure stirring stand, extract；
(5) a kind of prevention method of cataract or its progression inhibiting method, wherein black raspberry described in (1) has been used to mention
Take object.
Invention effect
According to the present invention it is possible to provide have the function of prevention or inhibit its be in progress certain kind of berries class extract, contain
There is the cataract of the extract of the certain kind of berries class to prevent or the manufacturing method of the extract of progression inhibiting agent and diet product and certain kind of berries class.Separately
Outside, according to the present invention it is possible to provide the prevention method or its progression inhibiting method of the cataract of extract for having used certain kind of berries class.
Detailed description of the invention
Fig. 1 is the figure for showing the alpha-crystal protein expression induction of certain kind of berries class sample and Blabina.
Specific embodiment
Hereinafter, being illustrated to black raspberry extract of the invention.Black raspberry extract of the invention, which has, to be prevented in white
The effect of barrier or the effect for inhibiting it to be in progress.
The black raspberry of raw material as black raspberry extract belongs to rose family rubus.In addition, black raspberry of the invention
It is preferable to use the extracts of the fruit mainly from black raspberry for extract.
From the fruit of black raspberry extract black raspberry extract method be not particularly limited, can be used solvent extraction,
Means of supercritical extraction etc..
As used Extraction solvent when carrying out solvent extraction, be not particularly limited, can be used water, organic solvent and
Their mixed solvent.It as organic solvent, can be used: the alcohols such as methanol, ethyl alcohol, normal propyl alcohol, isopropanol, n-butanol；Second
The glycols such as glycol, propylene glycol；Ethyl acetate；Acetone etc..These organic solvents can be used alone, and can also combine makes
With two or more.Furthermore it is possible to which the water solvents such as water and organic solvent are used in mixed way.
Wherein, preferred alcohol, the ethanol water for mixing ethyl alcohol and water, the concentration of the ethyl alcohol in ethanol water
Preferably 1~80v/v% (EtOH), more preferably 10~60v/v% (EtOH), further preferably 20~40v/v%
(EtOH)。
It should be noted that, it is preferable to use supercritical carbon dioxide is made in the case where carrying out means of supercritical extraction.
In addition, as carry out solvent extraction when extracting method, can be used stirring extraction, Soakage extraction, mechanical shaking extraction,
Refluxing extraction, ultrasonic wave extraction etc..Wherein, particularly preferably stirring is extracted.The method that stirring is extracted is not particularly limited, Ke Yijin
The stirring of enforcement blender uses stirring of stamping machine etc..
In addition, when being stirred extraction, on one side preferably with 500~20000rpm, more preferably with 1000~10000rpm, into
One step is preferably stirred with the mixing speed of 6000~10000rpm, carries out preferably a few minutes~60 minute, more excellent on one side
It is selected as extraction in 30 minutes~60 minutes.It should be noted that it is preferred that standing after agitation, carrying out standing extraction.It is more specific and
Speech is, it is preferable to use homogenizer is homogenized with 6000~10000rpm progress, is then allowed to stand progress in 24 hours for 30 minutes~60 minutes
It extracts.It should be noted that can be separated by solid-liquid separation by being stood, being extracted.
In addition, carrying out temperature when solvent extraction can be room temperature, or under heating condition.In addition, carrying out solvent
Pressure when extraction can be normal pressure, or under pressurization.
The processing such as it is filtered in addition, can according to need by the extracting solution that solvent extraction obtains.
Furthermore it is possible to make the extracting solution obtained by solvent extraction is dry powder is made.As drying means, can make
With well known method, the methods of spray drying, vacuum drying, freeze-drying can be used.
It should be noted that the commercially available product that liquid or powder is made or existing production can be used as black raspberry extract
Product.
Black raspberry extract of the invention can cooperate in food, beverage etc..As food, can enumerate Bread and Pastries,
Noodles, snack categories, edible meat processed goods, fish processed goods, frozen food, jellies, ice cream, dairy products, various condiment
Deng.In addition, can also cooperate in specific health food, quasi drug, healthy food, replenishers other than normal food.
As beverage, cold drink water, milk beverage, drinks, tea, black tea drinks, coffee, fruit drink, soda, mine can be enumerated
Spring class, beverage made of fruits or vegetables etc..
Furthermore it is possible to which the food, the beverage that are combined with black raspberry extract of the invention are made and tablet, capsule, sugar
The same forms of oral administration preparations such as slurry.
When manufacture is combined with food, the beverage of black raspberry extract of the invention, effect of the present invention can not interfered
In the range of sweetener, colorant, preservative, thickener, stabilizer, gelling agent, antioxidant, colour developing is added as needed
The additives such as agent, bleaching agent, emulsifier, swelling agent, acid, gloss agent, fragrance, solvent, oil.These additives can be independent
Using one kind, can also be applied in combination two or more.
Cooperating the ratio of the black raspberry extract in above-mentioned food, beverage can match according to purpose appropriate adjustment is used
The ratio for closing black raspberry extract in above-mentioned food, beverage is preferably 0.0001~80 weight %, more preferably 0.003~
50 weight %, further preferably 0.005~30 weight %.
Black raspberry extract of the invention is useful for the prevention of cataract or progression inhibiting.
Embodiment
Hereinafter, enumerating, examples illustrate the present invention, but the present invention is not limited thereto.As long as it should be noted that
It is not particularly illustrated, then part in the present embodiment and % are weight basis.In embodiment and comparative example, it has carried out based on ORAC
The evaluation of the induced expression of alpha-crystal albumen in the evaluation and lens cell of the antioxidation of value.
About sample
(preparation of sample) is used as sample, and using three kinds of certain kind of berries class samples, (black raspberry (rose family rubus) is (below sometimes
Referred to as " BR "), blueberry (Ericaceae Vaccinium) (hereinafter sometimes referred to " BB ") and raspberry (rose family rubus) (have below
When be known as " RB ")) extract and the powder formulation as the extract for being combined with black raspberry Blabina (registrar
Mark).
(preparation of extracting solution)
Black raspberry, blueberry and the extracting solution of raspberry obtain by the following method.
Firstly, black raspberry, blueberry and the fruit of raspberry are saved in a cold or frozen state respectively.Then, each fruit is thawed
And it cuts.(about 100g) black raspberry, blueberry and raspberry are weighed respectively, add 30v/v% (EtOH) ethanol water of 5 times of amounts
(about 500mL) carries out stirring in 30 minutes using stamping machine with 8000rpm and extracts.In turn, 24 hours are stood at room temperature, thus
Standing extraction is carried out, be filtered with 150 mesh and respectively obtains above-mentioned black raspberry, blueberry and the ethanol extract of raspberry.It is aftermentioned
The measurement of ORAC carried out under ethyl alcohol dissolved state, therefore, be measured using ethanol extract.
It should be noted that being made it dissolve in the way of making Blabina reach 9mg/mL in 30v/ about Blabina
In v% (EtOH).
(preparation of extract)
It is extracted respectively from the ethyl alcohol by the black raspberry of said extracted liquid being prepared, blueberry, raspberry using evaporator
Evaporating ethanol in the ethanol solution of liquid and Blabina, obtains extract.It should be noted that black raspberry, blueberry and raspberry
Ethanol extract contain the extract (extract) of 9mg/mL.
Measurement and evaluation
(evaluation of the antioxidation based on ORAC value)
Measure the ORAC value of three kinds of certain kind of berries classes sample (black raspberry, blueberry and the ethanol extract of raspberry) obtained above.It will
As a result it is shown in Table 1.It should be noted that not carrying out the measurement of ORAC value for Blabina.
[table 1]
| The type of sample | ORAC value (μM TE/g) |
| BR | 62 |
| BB | 66 |
| RB | 49 |
Compared with general antioxidant food, the ORAC value of three kinds of certain kind of berries class samples all shows high value (for general
The ORAC value of antioxidant food, referring to above-mentioned non-patent literature 4).In three kinds of certain kind of berries class samples, blueberry shows highest value, but
This is to be measured using ethanol extract as a result, it is thus impossible to being related to water soluble ingredient.
In addition, 0.1% or more ethyl alcohol can bring damage to cell, therefore, is carrying out having used the measurement of cell and comment
In the case where valence, the ethanol extract that has used 30 volume % ethanol waters and improper is utilized.Therefore, below crystalline
In the evaluation of the induced expression of alpha-crystal albumen in body cell, uses and evaporated from ethanol extract respectively by evaporator
Sample after removing alcohol component (referring to above-mentioned " preparation of extract ").
(induced expression of the alpha-crystal albumen in lens cell) uses lens cell (B-3, eyes I crystalline lens
(eye I lens), with adenovirus 12-SV40 viral hybridization body (Ad12-SV40, adenovirus 12-SV40virus
Hybrid it) is converted, people；ATCC number；CRL-11421) as cell used in experiment, using added with 10%FCS
D-MEM culture medium, in 37 DEG C, 5%CO2Under conditions of cultivated in the incubator.0.25% is utilized before it will test
Trypsase (Trypsin)/EDTA solution recycles cell, after carrying out Trypan Blue processing, utilizes automated cell calculating instrument
Countess (Invitrogen) calculates cell number.Then, 24 orifice plates or 96 orifice plates are inoculated in, used after preculture within 24 hours
In experiment.
By three kinds of certain kind of berries classes (black raspberry, blueberry and raspberry) extracts, Blabina obtained in the preparation of said extracted object
Removing ethyl alcohol after extract be dissolved separately in ultrapure water and about 11.5mg/mL be made, obtain sample.Then, by various kinds
This progress serial dilution (from 100000 times of dilution to 10 times of dilution), using quantitative PCR to the expression of alpha-crystal albumen-mRNA into
Row analysis.
It is carried out shown in specific step is as follows as quantitative PCR method.Using Trizol reagent (ambion) from being added with
Whole RNA are extracted in the lens cell of sample.According to PrimeScript RT Master Mix (Takara) method from
The RNA reverse transcription of extraction is cDNA, is expanded using SYBR Premix EX Taq II (Takara).It should be noted that
As PCR reaction solution, 50 μ L (25 μ L SYBR Green Mix (2x), 1 μ L cDNA, 2 μ L primer pair mix are used
(primer pair mixture) (5pmol/ μ L each primer (every kind of primer)), 22 μ L H2O PCR reaction solution) is reacted such as
It is carried out under the conditions of lower: so that the circulation for reacting 30 seconds at 95 DEG C is carried out 1 circulation, further make at being reacted 5 seconds and 60 DEG C at 95 DEG C
The circulation of reaction 30 seconds carries out 50 circulations.Relative quantification is carried out by comparing Ct method (Δ Δ Ct method).Used in RT-PCR
The primer of various targets and house-keeping gene (GAPDH) is shown in Table 2.
[table 2]
After sample after serial dilution is respectively added in lens cell, it was separately recovered at 1,4,8,12 hour complete
Portion RNA.Compared with BB, RB, Blabina, BR be dilute 100000 times in the case where also since addition 1 hour after show
The induced expression of alpha-crystal albumen out maintains high level until (referring to Fig. 1) after 12 hours.
In order to keep crystalline lens for a long time, there are various factors, although its mechanism not yet illustrates, crystalline protein is brilliant
The constituent of shape body, alpha-crystal albumen are obvious as the effect of the molecular chaperones for the association for preventing other β, γ-crystalline proteins
(for example, see Andley UP.Crystallins in the eye:Function and pathology.Prog Retin
Eye Res.2007Jan；26 (1): 78-98.).Blabina, BR show that the ability of the expression of induction alpha-crystal albumen is higher than
The tendency of other certain kind of berries class extracts.In addition, for prevention or inhibiting its progress, need chronically to keep crystalline lens, on
State result imply that prevention or inhibit its be in progress effect.
Claims (5)
1. a kind of black raspberry extract induces the expression of alpha-crystal albumen.
2. a kind of cataract prevention or progression inhibiting agent, contain black raspberry extract described in claim 1.
3. a kind of diet product contains black raspberry extract described in claim 1.
4. a kind of manufacturing method of black raspberry extract is the manufacturing method of black raspberry extract described in claim 1,
Include:
The freezing process that the fruit of black raspberry is freezed；
The defrosting process thawed to the fruit of the black raspberry；
The agitating procedure for adding solvent into the fruit of the black raspberry after being thawed using the defrosting process and being stirred；
With
The abstraction process that the fruit of the black raspberry after being stirred by the agitating procedure and solvent are stood, extracted.
5. a kind of prevention method of cataract or its progression inhibiting method, wherein black raspberry described in claim 1 has been used to mention
Take object.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017-154174 | 2017-08-09 | ||
| JP2017154174A JP6535710B2 (en) | 2017-08-09 | 2017-08-09 | Method of producing expression inducer of α-Crystallin, cataract prevention / progression inhibitor containing expression inducer of α-Crystallin, and expression inducer of α-Crystallin |
| PCT/JP2018/006354 WO2019030954A1 (en) | 2017-08-09 | 2018-02-22 | Black raspberry extract, cataract prevention/progression inhibitor including black raspberry extract, food and beverage, production method for black raspberry extract, cataract prevention method or progression inhibiting method using black raspberry extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110167572A true CN110167572A (en) | 2019-08-23 |
| CN110167572B CN110167572B (en) | 2022-03-25 |
Family
ID=65271292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880004844.XA Active CN110167572B (en) | 2017-08-09 | 2018-02-22 | Black raspberry extract, method for producing same, cataract prevention or progression inhibitor, and food and drink |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6535710B2 (en) |
| CN (1) | CN110167572B (en) |
| WO (1) | WO2019030954A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1683805A1 (en) * | 2003-10-24 | 2006-07-26 | Meiji Seika Kaisha Ltd. | Novel inhibitor for advanced glycation endproduct formation and aldose reductase inhibitor |
| CN102697893A (en) * | 2012-05-22 | 2012-10-03 | 辽宁大学 | Application of black raspberry extract (BRBE) in preparation of drugs for treating gastric cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128365A (en) * | 1989-07-19 | 1992-07-07 | The Trustees Of Columbia University In The City Of New York | Compounds having glutathione peroxidase activity and use thereof |
| JPH06199692A (en) * | 1992-03-06 | 1994-07-19 | Yunie:Kk | Agent for amelioration and treatment of cataract |
| US7208181B1 (en) * | 2002-06-12 | 2007-04-24 | The United States Of America, As Represented By The Secretary Of Agriculture | Isolation of polyphenolic compounds from fruits or vegetables utilizing sub-critical water extraction |
| CN1884467A (en) * | 2006-05-25 | 2006-12-27 | 任伟庆 | Black raspberry juice wine and process for preparation |
| KR100877371B1 (en) * | 2007-03-30 | 2009-01-09 | 주식회사 로제트 | Compositions for Protecting Eyesight |
| JP2013018734A (en) * | 2011-07-09 | 2013-01-31 | Nof Corp | Hyaluronic acid production promoter |
| CN102613631B (en) * | 2012-03-31 | 2014-02-12 | 贵州北极熊实业有限公司 | Black raspberry beverage and making method thereof |
| KR101978147B1 (en) * | 2012-11-15 | 2019-05-15 | (주)아모레퍼시픽 | Perfume composition for expressing the fragrance of Rubus coreanus Miquel |
| KR20160116487A (en) * | 2015-03-30 | 2016-10-10 | 전라북도 고창군 | Functional Gel Using Unripened Black Raspberry and Manufacturing Method Thereof |
| JP6643147B2 (en) * | 2016-03-04 | 2020-02-12 | 株式会社Ｓｕｂａｒｕ | Casting apparatus and casting method |
-
2017
- 2017-08-09 JP JP2017154174A patent/JP6535710B2/en active Active
-
2018
- 2018-02-22 CN CN201880004844.XA patent/CN110167572B/en active Active
- 2018-02-22 WO PCT/JP2018/006354 patent/WO2019030954A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1683805A1 (en) * | 2003-10-24 | 2006-07-26 | Meiji Seika Kaisha Ltd. | Novel inhibitor for advanced glycation endproduct formation and aldose reductase inhibitor |
| CN102697893A (en) * | 2012-05-22 | 2012-10-03 | 辽宁大学 | Application of black raspberry extract (BRBE) in preparation of drugs for treating gastric cancer |
Non-Patent Citations (4)
| Title |
|---|
| JIAHN-HAUR LIAO ET AL.: "Anti-cataractogenesis Mechanisms of Curcumin and a Comparison of its Degradation Products: an In Vitro Study", 《AGRICULTURAL AND FOOD CHEMISTRY》 * |
| RAFAELA G. FERESIN ET AL.: "Blackberry, raspberry and black raspberry polyphenol extracts attenuate angiotensin II-induced senescence in vascular smooth muscle cells", 《FOOD & FUNCTION》 * |
| SUSMITNARAYAN CHAUDHURY ET AL.: "Green tea flavanols protect human γB-crystallin from oxidative photodamage Susmitnarayan Chaudhury, Pritam Roy, Swagata Dasgupta", 《BIOCHIMIE》 * |
| YASUJIRO MORIMITSU ET AL.: "Inhibitory effect of anthocyanins and colored rice on diabetic cataract formation in the rat lenses", 《INTERNATIONAL CONGRESS SERIES》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6535710B2 (en) | 2019-06-26 |
| JP2019031467A (en) | 2019-02-28 |
| CN110167572B (en) | 2022-03-25 |
| WO2019030954A1 (en) | 2019-02-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Silva et al. | Food colour additives: A synoptical overview on their chemical properties, applications in food products, and health side effects | |
| Petrotos et al. | Production of novel bioactive yogurt enriched with olive fruit polyphenols | |
| JPWO2006030850A1 (en) | Method for preparing solubilized product of fat-soluble component | |
| UA104874C2 (en) | Reducing the acerbity of a composition comprising phenolic compounds | |
| Brauch et al. | Studies into the stability of 3-O-glycosylated and 3, 5-O-diglycosylated anthocyanins in differently purified liquid and dried maqui (Aristotelia chilensis (Mol.) Stuntz) preparations during storage and thermal treatment | |
| JP2010178655A (en) | Method for suppressing discoloration of crystalline carotenoid pigment | |
| Paraíso et al. | Ultrasound assisted extraction of hibiscus (Hibiscus sabdariffa L.) bioactive compounds for application as potential functional ingredient | |
| Ghareaghajlou et al. | Nano-liposomal system based on lyophilization of monophase solution technique for encapsulating anthocyanin-rich extract from red cabbage | |
| JP4305651B2 (en) | Carotenoid pigment emulsion | |
| JP2005185237A (en) | Method for producing water-based curcuma pigment preparation | |
| AU2015365315B2 (en) | Lycopene composition having improved colorant properties | |
| CN110167572A (en) | Black raspberry extract, the cataract prevention containing black raspberry extract or progression inhibiting agent and diet product, the manufacturing method of black raspberry extract and used black raspberry extract cataract prevention method or its progression inhibiting method | |
| JPWO2010055949A1 (en) | Malt extract and preparation method thereof | |
| CN110167573A (en) | Black raspberry extract, the alopecia inhibitor containing black raspberry extract and diet product, the manufacturing method of black raspberry extract and the alopecia suppressing method for having used black raspberry extract | |
| JP5948871B2 (en) | Polyphenol-containing composition | |
| KR101806020B1 (en) | A Healthy Beverage Containing a Spirulina Powder and the Method for Producing the Same | |
| KR20150144969A (en) | Moringa oleifera leaf extract with cancer improvement or prevention | |
| JP7271158B2 (en) | TRPA1 Activating Composition | |
| KR20170087396A (en) | Strain isolated from infant feces and method to produce fermented milk having antioxidative activity and improving immunsystem using the same | |
| JP2017186320A (en) | Emulsified composition and soft capsule formulation containing the same | |
| JP6618961B2 (en) | Activity inhibitor, whitening agent containing activity inhibitor, method for producing activity inhibitor, and method for producing food and drink | |
| KR101805974B1 (en) | Sausage prepared with mulberry and method for preparing the same | |
| JP2010202594A (en) | Fat metabolism promoter in skeletal muscle | |
| JP2007099671A (en) | Antioxidant composition | |
| Giaconia et al. | Bioaccessibility and antioxidant activity of anthocyanins from jaboticaba skins: the influence of OSA-modified starch concentration |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |