CN110152068B - Polyether-ether-ketone/nano-hydroxyapatite composite material and preparation method and application thereof - Google Patents

Polyether-ether-ketone/nano-hydroxyapatite composite material and preparation method and application thereof Download PDF

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CN110152068B
CN110152068B CN201910472563.3A CN201910472563A CN110152068B CN 110152068 B CN110152068 B CN 110152068B CN 201910472563 A CN201910472563 A CN 201910472563A CN 110152068 B CN110152068 B CN 110152068B
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hydroxyapatite
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polyether
ketone
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CN110152068A (en
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吴庆知
余珣知
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Wuhan University of Technology WUT
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

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Abstract

The invention discloses a polyether-ether-ketone/nano-hydroxyapatite composite material and a preparation method and application thereof. The preparation method comprises the following steps: 1) drying the polyether-ether-ketone in vacuum; 2) pouring the polyether-ether-ketone dried in the step 1) and the nano hydroxyapatite into a ball milling tank for ball milling; 3) pouring the mixed powder ball-milled in the step 2) into a double-screw extruder, and adjusting six zones of host current, host rotating speed, feeding rotating speed and temperature control in the extrusion process to obtain the polyetheretherketone/nano-hydroxyapatite composite material. The nano-hydroxyapatite in the obtained polyetheretherketone/nano-hydroxyapatite composite material is uniformly dispersed in the polyetheretherketone, has good biocompatibility and tissue affinity, has excellent mechanical strength, and can be used in the fields of hard tissue medical implant preparation, medical cosmetology and the like.

Description

Polyether-ether-ketone/nano-hydroxyapatite composite material and preparation method and application thereof
Technical Field
The invention belongs to the field of biological material preparation, and particularly relates to a polyether-ether-ketone/nano-hydroxyapatite composite material as well as a preparation method and application thereof.
Technical Field
Polyether-ether-ketone (PEEK) is a high-performance engineering plastic, and can be used for antibacterial treatment besides good mechanical property, stable physicochemical property, stability under irradiation, high hydrolysis resistance and high thermal stability, so that the PEEK has great application potential as a hard tissue repair material. However, studies have shown that: the hydrophobic property and chemical inertness of the surface of the pure polyetheretherketone material can not be effectively combined with biological tissues, so that the pure polyetheretherketone material has strong biological inertness (namely low histocompatibility), low tensile strength and difficulty in meeting the actual application requirements of clinical medical implants, and the clinical application of the pure polyetheretherketone material is severely restricted. The bioactivity of the polyether-ether-ketone can be effectively enhanced by adding hydroxyapatite into the polyether-ether-ketone. The existing injection molding or hot press molding process for preparing the polyetheretherketone-hydroxyapatite composite material is often to improve the biocompatibility and the tissue affinity, and the problem of uniform dispersibility of the nanoparticles in the matrix is not solved, so that the nanoparticles are greatly agglomerated in the matrix, and the mechanical properties, particularly the tensile strength, of the composite material are seriously reduced, and potential safety hazards exist in clinical application, so that the actual requirements of the clinical application are difficult to meet. Up to now, how to improve the biocompatibility and tissue affinity of the polyetheretherketone composite material and improve the mechanical strength, especially the tensile strength, is still a key technical problem in the field.
Disclosure of Invention
The invention aims to provide a method for preparing a polyetheretherketone/nano-hydroxyapatite composite material, which is simple to operate and easy for large-scale production, and the prepared polyetheretherketone/nano-hydroxyapatite composite material has good mechanical properties, good biocompatibility and tissue compatibility as well as nano-hydroxyapatite uniformly dispersed in polyetheretherketone.
In order to solve the technical problems, the invention provides the following technical scheme:
a method for preparing a polyetheretherketone/nano-hydroxyapatite composite material comprises the following steps:
1) drying the polyether-ether-ketone in vacuum;
2) pouring the polyether-ether-ketone dried in the step 1) and the nano hydroxyapatite into a ball milling tank for ball milling;
3) pouring the mixed powder ball-milled in the step 2) into a double-screw extruder, and adjusting the current of a host, the rotating speed of the host, the feeding rotating speed and the temperature control six areas in the extrusion process to obtain the polyetheretherketone/nano-hydroxyapatite composite material.
According to the scheme, the nano-hydroxyapatite in the step 2) is needle-shaped, rod-shaped or fibrous.
According to the scheme, the needle-shaped nano hydroxyapatite has the length of 140-160nm and the width of 15-25 nm; the length of the rod-shaped nano hydroxyapatite is 90-110nm, and the width of the rod-shaped nano hydroxyapatite is 25-35 nm; the length of the fibrous nano-hydroxyapatite is 490-510nm, and the width is 5-15 nm.
According to the scheme, the needle-shaped nano hydroxyapatite accounts for 10-30% of the total mass of the polyether-ether-ketone and the needle-shaped nano hydroxyapatite in mass ratio, and preferably 20-30%.
According to the scheme, the mass ratio of the rod-shaped nano hydroxyapatite is 5-15%, preferably 8-12% of the total mass of the polyether-ether-ketone and the rod-shaped nano hydroxyapatite.
According to the scheme, the mass ratio of the fibrous nano hydroxyapatite is 10-30%, preferably 20-30% of the total mass of the polyether-ether-ketone and the fibrous nano hydroxyapatite.
According to the scheme, the vacuum drying conditions in the step 1) are as follows: drying in a vacuum drying oven at 120-150 deg.c for 12-24 hr.
According to the scheme, the ball milling conditions in the step 2) are as follows: 300-600rpm, the time is 2-4h, the ball-material ratio is (1-1.5): 1.
according to the scheme, in the step 3), the current of the host is 1-10A, the rotating speed of the host is 90-180rpm, the feeding rotating speed is 10-20Hz, and the six temperature control areas of the extruder are 290 ℃ and 370 ℃.
Preferably, the rotation speed of the host in the step 3) is 100-120rpm, the feeding rotation speed is 9-11Hz, and the temperature control six zones are 300-360 ℃.
The polyether-ether-ketone/nano-hydroxyapatite composite material prepared by the method.
The application of the polyetheretherketone/nano-hydroxyapatite composite material can be used for preparing hard tissue medical implants and medical cosmetology.
The nanometer hydroxyapatite is modified with polyether ether ketone to obtain the nanometer composite material, which can enhance the biocompatibility and tissue affinity of the composite material, but the application of the nanometer hydroxyapatite is limited because the mechanical strength of the nanometer hydroxyapatite is reduced due to easy agglomeration. In order to solve the problem of dispersibility of the nano-hydroxyapatite in the polyether-ether-ketone, firstly, ball-milling pretreatment is carried out to uniformly disperse the nano-hydroxyapatite in the polyether-ether-ketone, and then, after uniform mixing, a mixture of the nano-hydroxyapatite and the polyether-ether-ketone is melted in a double screw extruder for secondary mixing, so that the dispersibility of the nano-hydroxyapatite in the polyether-ether-ketone is further improved. The nano hydroxyapatite has large specific surface area, and can more effectively hinder the formation and the expansion of cracks after being uniformly dispersed in the polyether-ether-ketone, thereby improving the mechanical property of the composite material. The polyether-ether-ketone/nano-hydroxyapatite composite material with uniform dispersion is prepared by a composite modification process combining ball milling, premixing and double-screw extrusion, so that the problem of reduction of the mechanical property of the composite material due to an agglomeration effect in the forming process of the polyether-ether-ketone/nano-hydroxyapatite composite material is solved.
The invention has the beneficial effects that:
1. according to the invention, through a composite modification process combining ball milling, premixing and double-screw extrusion, the nano-hydroxyapatite is uniformly dispersed in the polyetheretherketone, so that the technical problems of stress concentration and final reduction of the mechanical property of the composite material caused by the agglomeration effect of the nano-hydroxyapatite are solved, the biological activity is improved, and the mechanical property of the polyetheretherketone/nano-hydroxyapatite composite material is further improved.
2. The polyether-ether-ketone/nano-hydroxyapatite composite material obtained by the invention not only has good biocompatibility and tissue affinity, but also has excellent mechanical strength, wherein the tensile strength can reach 104.67 +/-1.98 MPa at most, and the composite material can be used in the fields of hard tissue medical implant preparation, medical cosmetology and the like.
Drawings
FIG. 1 is a transmission electron microscope image of the PEEK/hydroxyapatite nanoparticles (needle-like) composite obtained in example 1.
Fig. 2 is a scanning electron microscope image of the tensile fracture surface of the polyetheretherketone/nano-hydroxyapatite (needle-like) composite material obtained in example 1, wherein a is a scanning electron microscope image magnified 20000 times and b is a scanning electron microscope image magnified 10000 times.
FIG. 3 is a comparison graph of the cell adhesion between the PEEK/hydroxyapatite nanoparticles (needles) composite obtained in example 1 and PEEK.
FIG. 4 is a transmission electron microscope image of the PEEK/hydroxyapatite nanoparticles (needle-like) composite obtained in example 2.
Fig. 5 is a scanning electron microscope image of the tensile fracture surface of the polyetheretherketone/nano-hydroxyapatite (needle-like) composite obtained in example 2, wherein a is a scanning electron microscope image magnified 20000 times and b is a scanning electron microscope image magnified 10000 times.
FIG. 6 is a comparison graph of the cell adhesion between the PEEK/hydroxyapatite nanoparticles (needles) composite obtained in example 2 and PEEK.
FIG. 7 is a TEM image of the PEEK/hydroxyapatite nanoparticles (rods) composite obtained in example 3.
FIG. 8 is a scanning electron microscope image of the tensile fracture surface of the polyetheretherketone/hydroxyapatite nanoparticles (rod-like) composite obtained in example 3, wherein a is 20000 times and b is 10000 times.
FIG. 9 is a comparison graph of the cell adhesion between the PEEK/hydroxyapatite nanoparticles (rod-like) composite obtained in example 3 and PEEK.
Fig. 10 is a transmission electron microscope image of the polyetheretherketone/nano-hydroxyapatite (fibrous) composite obtained in example 4.
Fig. 11 is a scanning electron microscope image of the tensile fracture surface of the polyetheretherketone/nano-hydroxyapatite (fibrous) composite obtained in example 4, wherein a is a scanning electron microscope image magnified 20000 times and b is a scanning electron microscope image magnified 10000 times.
FIG. 12 is a comparison graph of the cell adhesion between the PEEK/nano-hydroxyapatite (fibrous) composite obtained in example 4 and PEEK.
FIG. 13 is a TEM image of the PEEK/hydroxyapatite (fibrous) composite obtained in example 5.
Fig. 14 is a scanning electron microscope image of the tensile fracture surface of the polyetheretherketone/nano-hydroxyapatite (fibrous) composite obtained in example 5, wherein a is 20000 times magnified scanning electron microscope image, and b is 10000 times magnified scanning electron microscope image.
FIG. 15 is a comparison graph of the cell adhesion between the PEEK/hydroxyapatite (fibrous) composite obtained in example 5 and PEEK.
Detailed Description
The invention will be further described with reference to the following examples and drawings, but the following examples should not be construed as limiting the invention.
The ball mill used in the embodiment of the invention is manufactured by Changsha Tianchu powder technology company Limited and has the model number of XQM-4; the double-screw extruder is manufactured by Nanjing Polydyme chemical machinery Co., Ltd, and has the model number of SHJ-20.
Example 1:
the preparation method of the polyetheretherketone/nano-hydroxyapatite (needle-shaped) composite material comprises the following specific steps:
140g of polyetheretherketone raw material is placed in a vacuum drying oven, vacuum drying is carried out for 12 hours at 120 ℃, and the raw material is sealed and stored for standby after the drying is finished. 60g of needle-shaped nano hydroxyapatite (the needle-shaped nano hydroxyapatite accounts for 30 percent of the total mass of the polyether-ether-ketone and the needle-shaped nano hydroxyapatite according to the mass ratio) is weighed and mixed by a ball mill (the ball-material ratio is 1: 1) for pretreatment. The rotation speed of the ball mill is adjusted to 400rpm, and the ball milling is carried out for 2 hours. Pouring the ball-milled premixed mixed powder into a double-screw extruder, in the extrusion compounding process, keeping the current of a host machine at 1-10A, the rotating speed of the host machine at 110rpm and the feeding rotating speed at 10Hz, controlling the temperature in six zones of 300, 330, 350, 355, 350 and 360 ℃ respectively, and extruding for 25min to obtain the polyether-ether-ketone/nano-hydroxyapatite (needle) composite material, wherein the tensile strength test result shows that the tensile strength is 104.67 +/-1.98 MPa.
Fig. 1 is a transmission electron microscope image of the peek/nano hydroxyapatite (acicular) composite prepared in this example, fig. 2 is a scanning electron microscope image of a tensile fracture surface thereof, in which fig. a is a scanning electron microscope image magnified 20000 times, fig. b is a scanning electron microscope image magnified 10000 times, and fig. 1 and 2 show that the acicular nano hydroxyapatite is uniformly dispersed in the peek matrix. FIG. 3 is a comparison graph of cell adhesion between PEEK/NANOhydroxyapatite (acicular) composite material and PEEK prepared in this example, in which the surfaces of the composite material and PEEK are seeded with 3 × 10 particles4And culturing the individual cells for 6, 12 and 24 hours respectively, and then detecting the cell adhesion condition. The results in fig. 3 show that the adhesion condition of the cells on the surface of the polyetheretherketone/nano-hydroxyapatite (needle-like) composite material is obviously better than that of a pure polyetheretherketone material, which indicates that the prepared composite material has better biological activity.
Example 2:
the preparation method of the polyetheretherketone/nano-hydroxyapatite (needle-shaped) composite material comprises the following specific steps:
putting 180g of polyether-ether-ketone raw material into a vacuum drying oven, vacuum-drying for 12 hours at 120 ℃, and hermetically storing for later use after drying. 20g of needle-shaped nano hydroxyapatite (the needle-shaped nano hydroxyapatite accounts for 10 percent of the total mass of the polyether-ether-ketone and the needle-shaped nano hydroxyapatite according to the mass ratio) is weighed and mixed by a ball mill (the ball-material ratio is 1: 1) for pretreatment. The rotation speed of the ball mill is adjusted to 400rpm, and the ball milling is carried out for 2 hours. Pouring the ball-milled premixed mixed powder into a double-screw extruder, in the extrusion compounding process, keeping the current of a host machine at 1-10A, the rotating speed of the host machine at 110rpm and the feeding rotating speed at 10Hz, controlling the temperature in six zones of 300, 330, 350, 355, 350 and 360 ℃ respectively, and extruding for 25min to obtain the polyether-ether-ketone/nano-hydroxyapatite (needle) composite material, wherein the tensile strength test result shows that the tensile strength is 101.08 +/-1.51 MPa.
Fig. 4 is a transmission electron microscope image of the peek/nano hydroxyapatite (acicular) composite prepared in this example, fig. 5 is a scanning electron microscope image of a tensile fracture surface thereof, in which fig. a is a scanning electron microscope image magnified 20000 times, fig. b is a scanning electron microscope image magnified 10000 times, and fig. 4 and 5 show that the acicular nano hydroxyapatite is uniformly dispersed in the peek matrix. FIG. 6 is a comparison graph of cell adhesion between PEEK/NANOhydroxyapatite (acicular) composite material and PEEK prepared in this example, in which the surfaces of the composite material and PEEK are seeded with 3 × 10 particles4And culturing the individual cells for 6, 12 and 24 hours respectively, and then detecting the cell adhesion condition. The results in fig. 6 show that the adhesion condition of the cells on the surface of the polyetheretherketone/nano-hydroxyapatite (needle-like) composite material is obviously better than that of the pure polyetheretherketone material, which indicates that the prepared composite material has better biological activity.
Example 3:
the preparation method of the polyether-ether-ketone/nano-hydroxyapatite (rod-shaped) composite material comprises the following specific steps:
putting 180g of polyether-ether-ketone raw material into a vacuum drying oven, vacuum-drying for 12 hours at 120 ℃, and hermetically storing for later use after drying. Weighing 20g of rod-shaped nano hydroxyapatite (the mass ratio of the rod-shaped nano hydroxyapatite is 10 percent of the total mass of the polyether-ether-ketone and the rod-shaped nano hydroxyapatite), and performing blending pretreatment by a ball mill (the ball-material ratio is 1: 1). The rotation speed of the ball mill is adjusted to 500rpm, and the ball milling is carried out for 2 hours. Pouring the ball-milled premixed mixed powder into a double-screw extruder, in the extrusion compounding process, keeping the current of a main machine at 1-10A, the rotating speed of the main machine at 120rpm and the feeding rotating speed at 10.9Hz, controlling the temperature in six zones of 300, 330, 350, 355, 350 and 360 ℃ respectively, and extruding for 25min to obtain the polyether-ether-ketone/nano-hydroxyapatite (rod-shaped) composite material, wherein the tensile strength test result shows that the tensile strength is 102.95 +/-0.49 MPa.
Fig. 7 is a transmission electron microscope image of the peek/nano-hydroxyapatite (rod-like) composite prepared in this example, fig. 8 is a scanning electron microscope image of a tensile fracture surface thereof, in which fig. a is a scanning electron microscope image magnified 20000 times, fig. b is a scanning electron microscope image magnified 10000 times, and fig. 7 and 8 show that the rod-like nano-hydroxyapatite is uniformly dispersed in the peek matrix. FIG. 9 is a comparison graph of cell adhesion between PEEK/hydroxyapatite nanoparticles (rods) and PEEK prepared in this example, in which the surfaces of the PEEK/hydroxyapatite nanoparticles (rods) and the PEEK were seeded with 3X 10 particles4And culturing the individual cells for 6, 12 and 24 hours respectively, and then detecting the cell adhesion condition. The results of fig. 9 show that the adhesion condition of the cells on the surface of the polyetheretherketone/nano-hydroxyapatite (rod-like) composite material is obviously better than that of a pure polyetheretherketone material, which indicates that the prepared composite material has better biological activity.
Example 4:
the preparation method of the polyetheretherketone/nano-hydroxyapatite (fibrous) composite material comprises the following specific steps:
140g of polyetheretherketone raw material is placed in a vacuum drying oven, vacuum drying is carried out for 12 hours at 120 ℃, and the raw material is sealed and stored for standby after the drying is finished. 60g of fibrous nano-hydroxyapatite (30 percent of the total mass of the polyether-ether-ketone and the fibrous nano-hydroxyapatite in terms of mass ratio) is weighed and mixed by a ball mill (the ball material ratio is 1: 1) for pretreatment. The rotation speed of the ball mill is adjusted to 450rpm, and the ball milling is carried out for 2 hours. Pouring the ball-milled premixed mixed powder into a double-screw extruder, and in the extrusion compounding process, keeping the current of a main machine at 1-10A, the rotating speed of the main machine at 110rpm and the feeding rotating speed at 10.2Hz, controlling the temperature in six zones of 300, 330, 350, 355, 350 and 360 ℃ respectively, and extruding for 25min to obtain the polyether-ether-ketone/nano-hydroxyapatite (fibrous) composite material, wherein the tensile strength test result shows that the tensile strength is 102.95 +/-0.49 MPa.
Fig. 10 is a transmission electron microscope image of the peek/nano-hydroxyapatite (fibrous) composite material prepared in this example, fig. 11 is a scanning electron microscope image of a tensile fracture surface thereof, in which fig. a is a scanning electron microscope image magnified 20000 times, fig. b is a scanning electron microscope image magnified 10000 times, and fig. 10 and 11 show that the fibrous nano-hydroxyapatite is uniformly dispersed in the peek matrix. FIG. 12 is a comparison graph of cell adhesion between the PEEK/NANOhydroxyapatite (fibrous) composite material and PEEK prepared in this example, in which the composite material and the PEEK are seeded with 3 × 10 particles4And culturing the individual cells for 6, 12 and 24 hours respectively, and then detecting the cell adhesion condition. The results in fig. 12 show that the adhesion condition of the cells on the surface of the polyetheretherketone/nano-hydroxyapatite (fibrous) composite material is obviously better than that of the pure polyetheretherketone material, which indicates that the prepared composite material has better biological activity.
Example 5:
the preparation method of the polyetheretherketone/nano-hydroxyapatite (fibrous) composite material comprises the following specific steps:
putting 180g of polyether-ether-ketone raw material into a vacuum drying oven, vacuum-drying for 12 hours at 120 ℃, and hermetically storing for later use after drying. Weighing 20g of fibrous nano-hydroxyapatite (the mass ratio of the fibrous nano-hydroxyapatite is 10 percent of the total mass of the polyether-ether-ketone and the fibrous nano-hydroxyapatite), and performing blending pretreatment by a ball mill (the ball material ratio is 1: 1). The rotation speed of the ball mill is adjusted to 450rpm, and the ball milling is carried out for 2 hours. Pouring the ball-milled premixed mixed powder into a double-screw extruder, and in the extrusion compounding process, keeping the current of a main machine at 1-10A, the rotating speed of the main machine at 110rpm and the feeding rotating speed at 10.2Hz, controlling the temperature in six zones of 300, 330, 350, 355, 350 and 360 ℃ respectively, and extruding for 25min to obtain the polyether-ether-ketone/nano-hydroxyapatite (fibrous) composite material, wherein the tensile strength test result shows that the tensile strength is 100.57 +/-0.66 MPa.
FIG. 13 is a transmission electron microscope image of the PEEK/nano-hydroxyapatite (fibrous) composite material prepared in the present example, and FIG. 14 is a scanning electron microscope image of a tensile fracture surface thereof, wherein FIG. a is a scanning electron microscope image magnified 20000 timesThe mirror image, the image b is the scanning electron microscope image magnified 10000 times, and the images 13 and 14 show that the fibrous nano hydroxyapatite is uniformly dispersed in the polyetheretherketone matrix. FIG. 15 is a comparison graph of cell adhesion between the PEEK/NANOhydroxyapatite (fibrous) composite material and PEEK prepared in this example, in which the composite material and the PEEK are seeded with 3 × 10 particles4And culturing the individual cells for 6, 12 and 24 hours respectively, and then detecting the cell adhesion condition. The results in fig. 15 show that the adhesion condition of the cells on the surface of the polyetheretherketone/nano-hydroxyapatite (fibrous) composite material is obviously better than that of the pure polyetheretherketone material, which indicates that the prepared composite material has better biological activity.

Claims (5)

1. A method for preparing a polyetheretherketone/nano-hydroxyapatite composite material is characterized by comprising the following steps:
1) drying the polyether-ether-ketone in vacuum;
2) pouring the polyether-ether-ketone dried in the step 1) and nano-hydroxyapatite into a ball milling tank for ball milling, wherein the nano-hydroxyapatite is needle-shaped, rod-shaped or fibrous, and the needle-shaped nano-hydroxyapatite accounts for 10-30% of the total mass of the polyether-ether-ketone and the needle-shaped nano-hydroxyapatite in terms of mass ratio; the rod-shaped nano hydroxyapatite accounts for 5 to 15 percent of the total mass of the polyether-ether-ketone and the rod-shaped nano hydroxyapatite in mass ratio; the mass ratio of the fibrous nano hydroxyapatite is 10-30% of the total mass of the polyether-ether-ketone and the fibrous nano hydroxyapatite; the needle-shaped nano hydroxyapatite has the length of 140 nm and the width of 15-25 nm; the length of the rod-shaped nano hydroxyapatite is 90-110nm, and the width of the rod-shaped nano hydroxyapatite is 25-35 nm; the length of the fibrous nano hydroxyapatite is 490-510nm, and the width is 5-15 nm; the ball milling time is 2-4 h;
3) pouring the mixed powder ball-milled in the step 2) into a double-screw extruder, and adjusting six zones of host current, host rotating speed, feeding rotating speed and temperature control in the extrusion process to obtain the polyether-ether-ketone/nano-hydroxyapatite composite material; wherein: the current of the main machine is 1-10A, the rotating speed of the main machine is 100-120rpm, the feeding rotating speed is 9-11Hz, and the six temperature control areas of the extruder are 300-360 ℃.
2. The method for preparing the polyetheretherketone/nano-hydroxyapatite composite material according to claim 1, wherein the needle-shaped nano-hydroxyapatite is 20 to 30 percent of the total mass of the polyetheretherketone and the needle-shaped nano-hydroxyapatite in mass ratio; the rod-shaped nano hydroxyapatite accounts for 8 to 12 percent of the total mass of the polyether ether ketone and the rod-shaped nano hydroxyapatite in mass ratio; the mass ratio of the fibrous nano hydroxyapatite is 20-30% of the total mass of the polyether-ether-ketone and the fibrous nano hydroxyapatite.
3. The method for preparing the polyetheretherketone/nano-hydroxyapatite composite material according to claim 1, wherein the vacuum drying conditions in the step 1) are as follows: dewatering and drying for 12-24 hours in a vacuum drying oven at 120-150 ℃; the ball milling conditions in the step 2) are as follows: the rotating speed is 300-600rpm, the ball material ratio is (1-1.5): 1.
4. a polyetheretherketone/nano-hydroxyapatite composite material, characterized in that it is prepared by the method of any one of claims 1 to 3.
5. Use of the polyetheretherketone/nanohydroxyapatite composite material according to claim 4 for the preparation of medical implants for hard tissues and for the preparation of medical cosmetic materials.
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