CN110151819A - A kind of new machining method of river Radix Salviae Miltiorrhizae - Google Patents
A kind of new machining method of river Radix Salviae Miltiorrhizae Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
The present invention provides a kind of new machining methods of river Radix Salviae Miltiorrhizae, belong to Radix Salviae Miltiorrhizae processing technique field, the following steps are included: first excavating fresh middle river red sage root item, select that quality is good and the root item of robust growth, the silt on Radix Salviae Miltiorrhizae surface is removed by cleaning and is stained, draining and the moisture on root surface is dried after cleaning, red sage root item is put into microtome, Danshen Tablets after slice are put into sterile tray and are put neatly, and this pallet is put into freeze dryer, and 17 stage runnings are set, total time-consuming 60.05-90.05 hours, preceding 10 stages are the cooling icing stages, 7 stages are the temperature rise period afterwards, and cooperate vacreation, pass through the stage of low temperature to room temperature, in the effect of cooperation vacuum, the effective component of Radix Salviae Miltiorrhizae can absolutely be lockked, loss is not will cause, cryogenic freezing adds dry compared with normal temperature It is dry, so that effective component is not killed, in addition, having cooperated low temperature, vacuum and the bactericidal effect compared with room temperature, the Danshen Tablets quality of production is high.
Description
Technical field
The present invention relates to Radix Salviae Miltiorrhizae processing technique field, the new machining method of specifically a kind of river Radix Salviae Miltiorrhizae.
Background technique
Radix Salviae Miltiorrhizae is Lamiaceae Salvia category, and herbaceos perennial, because it is dried, root and rhizome takes on a red color and shape is like ginseng
And gain the name " Radix Salviae Miltiorrhizae ", also known as blood ginseng, radix salviae miltiorrhizae and RADIX SALVIAE MILTIORRHIZAE etc..
Radix Salviae Miltiorrhizae is the common bulk medicinal materials of China, has the effects that antipyretic, antibacterial, calm, decompression, transaminase lowering.High-quality medicine
Material producing region is usually that the secondary distributed area of plant, non-optimum growth district, therefore adverse environment locating for high-quality medicinal material influence to produce
The raising of amount.I.e. high-quality producing region is generally not prolific area.Secondly, under cultivation condition, by the measures such as irrigating, applying fertilizer significantly
The growing environment for obtaining improving plant, under the conditions of this, unfavorable Secondary metabolites (the usually medicinal ingredient of Radix Salviae Miltiorrhizae)
Generation, Genuine producing area cultivation will not guarantee increasing substantially for quality of medicinal material.Third, Genuine producing area due to by landform,
Fertilising, annual rainfall the factors such as difference keep the quality of medicinal material in Genuine producing area irregular, be also difficult to guarantee whole quality of medicinal material
Raising.
The technical solution of prior art production Radix Salviae Miltiorrhizae: China and in June, 2003 start formally to implement " Producing medicinal herbs matter
Measure management regulation " (GAP), from variety selection, planting area selection, cultivation technique (seed treatment, site preparation, fertilising, irrigation, kind
Density in planting, tillage and weeding, prevention and control of plant diseases, pest control etc.), collecting time, the links such as processing technology production is standardized, to protect
Demonstrate,prove the raising and stabilization of quality of medicinal material.
The method of traditional processing Radix Salviae Miltiorrhizae the methods of generally dries, dries, dries in the shade, and maximum problem is effective component
It is lost and active constituent is killed.
Summary of the invention
There are the loss of effective component and the killed defects of active constituent for the method for above-mentioned existing processing Radix Salviae Miltiorrhizae.
The purpose of the present invention is to provide a kind of new machining methods of river Radix Salviae Miltiorrhizae, comprising the following steps:
(1) fresh middle river red sage root item is excavated；
(2) red sage root item is selected；
(3) it cleans；
(4) Danshen Tablets are sliced to obtain to the red sage root item after cleaning；
(6) Danshen Tablets are freeze-dried；
(7) freeze-drying is divided into 17 stage runnings, and preceding 10 stages are the cooling icing stages, and rear 7 stages are heating
Stage, and cooperate vacreation, total time-consuming 60.05-90.05 hours.
In the technical solution of the application, fresh middle river red sage root item is first excavated, selects that quality is good and the root of robust growth
Item removes the silt on Radix Salviae Miltiorrhizae surface by cleaning and is stained, and draining and the moisture on root surface is dried after cleaning, by red sage root
Item is put into microtome, and the Danshen Tablets after slice are put into sterile tray and are put neatly, and this pallet is put into freeze dryer,
And 17 stage runnings are set, total time-consuming 60.05-90.05 hour, preceding 10 stages were the icing stages that cools down, and rear 7 stages are
Temperature rise period, and cooperate vacreation, it can absolutely be lockked by the stage of low temperature to room temperature in the effect of cooperation vacuum
The effective component of Radix Salviae Miltiorrhizae not will cause loss, and cryogenic freezing adds the drying compared with normal temperature, effective component is made not to be killed,
In addition, having cooperated low temperature, vacuum and the bactericidal effect compared with room temperature, the Danshen Tablets quality of production is high, after processing is completed puts product
Enter in vacuum tank and save, solving the above-mentioned existing method for processing Radix Salviae Miltiorrhizae, there are the losses of effective component and active constituent to be killed
Dead defect.
The application utilizes vacuum refrigeration in the case where guaranteeing that its active constituent is constant according to the biological nature of river Radix Salviae Miltiorrhizae
Dry technology is dried, and the Danshen Tablets after drying can keep original physiological activity to greatest extent, is made contained by it
Various natural function ingredients obtain maximum protection in the drying process, can not only keep natural shape but also its sense organ product can be improved
Matter.
The Danshen Tablets of the new machining method production of the application river Radix Salviae Miltiorrhizae are of light color, and dry product, which enters water 8 minutes, just can become fresh goods
Apperance, the Danshen Tablets of produced in conventional processes have apparent sundries and a foam, the Danshen Tablets of the application without any sundries, and it is soaked after
Float on surface layer, it is in good taste.
Preferably, it is to select the above red sage root item of level-one that step (2), which selects the standard of red sage root item, i.e., diameter is in 0.7-
Red sage root item between 1.2cm.The above red sage root robust growth of level-one, quality is high, facilitates slice and following process.
Preferably, the Radix Salviae Miltiorrhizae after cleaning is put into microtome with item in step (4), Danshen Tablets with a thickness of 1.35-
2.35mm.Slicer is the slicer of this field routine, can be commercially available corresponding product on the market.
More preferably, Danshen Tablets with a thickness of 1.85mm.Nutrient loss is minimum after the Danshen Tablets processing of this thickness,
And impurity will not be generated, be lost minimum in process, furthermore facilitate slice, too thin bad slice, too it is thick be freeze-dried it is not thorough
Bottom.
Preferably, 17 stages are respectively to freeze in the 1st stage in order in step (7), 1-2 hours at -50 DEG C, vacuum shape
State is 0Pa；2nd stage vacuumized, 0.5-1.5 hours at -50 DEG C, vacuum state 5-10Pa；3rd stage started to distil, and -40
1.05-3.05 hours at DEG C, vacuum state 5-10Pa；4th stage distilled, 1.05-3.05 hours at -35 DEG C, vacuum state
For 5-10Pa；5th stage distilled, 1.05-3.05 hours at -30 DEG C, vacuum state 5-10Pa；The distillation of 6th stage, -25 DEG C
Lower 1.05-2.05 hours, vacuum state 5-10Pa；7th stage distilled, and 1.05-2.05 hours at -20 DEG C, vacuum state is
5-10Pa；8th stage distilled, 2.05-3.05 hours at -15 DEG C, vacuum state 5-10Pa；9th stage distilled, at -10 DEG C
1.05-2.05 hours, vacuum state 5-10Pa；10th stage distilled, 3.05-5.05 hours at -5 DEG C, vacuum state 5-
10Pa；11st stage distilled, 3.05-5.05 hours at 0 DEG C, vacuum state 5-10Pa；12nd stage distilled, 1.05- at 5 DEG C
3.05 hours, vacuum state 5-10Pa；13rd stage distilled, 1.05-3.05 hours at 10 DEG C, vacuum state 5-10Pa；
14th stage distilled, 3-5 hours at 15 DEG C, vacuum state 5-10Pa；15th stage distilled, 4-6 hours at 20 DEG C, vacuum shape
State is 5-10Pa；16th stage distilled, 7-9 hours at 25 DEG C, vacuum state 5Pa；17th stage distilled, 28-32 at 30 DEG C
Hour, vacuum state 5Pa.Through elder generation under -50 DEG C of low temperature, the nutrition of Danshen Tablets can be lockked rapidly, after freezing a period of time
Temperature is successively uniformly turned up, respectively -40 DEG C, -35 DEG C, -30 DEG C, -20 DEG C, -15 DEG C, -10 DEG C and -5 DEG C are to 0 DEG C, until temperature
Degree is increased to 30 DEG C, and cooperates different vacuum states in the process to sterilize, and under vacuum conditions, most of microorganism is because of nothing
Oxygen apnea and it is dead, that is, sterilize, furthermore under the conditions of negative pressure of vacuum, the boiling point of the moisture in Radix Salviae Miltiorrhizae is down to lower temperature and starts to steam
Hair, plays good desiccation.
More preferably, 17 stages are respectively to freeze in the 1st stage in order in step (7), 1.5 hours at -50 DEG C, very
Dummy status is 0Pa；2nd stage vacuumized, 1 hour at -50 DEG C, vacuum state 7Pa；3rd stage started to distil, at -40 DEG C
2.05 hours, vacuum state 7Pa；4th stage distilled, 2.05 hours at -35 DEG C, vacuum state 7Pa；5th stage liter
China, 2.05 hours at -30 DEG C, vacuum state 7Pa；6th stage distilled, 1.55 hours at -25 DEG C, vacuum state 7Pa；The
7 stages distilled, 1.55 hours at -20 DEG C, vacuum state 7Pa；8th stage distilled, 2.55 hours at -15 DEG C, vacuum state
For 7Pa；9th stage distilled, 1.55 hours at -10 DEG C, vacuum state 7Pa；10th stage distilled, 4.05 hours at -5 DEG C,
Vacuum state is 7Pa；11st stage distilled, 4.05 hours at 0 DEG C, vacuum state 7Pa；12nd stage distilled, 2.05 at 5 DEG C
Hour, vacuum state 7Pa；13rd stage distilled, 2.05 hours at 10 DEG C, vacuum state 7Pa；The distillation of 14th stage, 15
4 hours at DEG C, vacuum state 7Pa；15th stage distilled, 5 hours at 20 DEG C, vacuum state 7Pa；The distillation of 16th stage,
8 hours at 25 DEG C, vacuum state 5Pa；17th stage distilled, 30 hours at 30 DEG C, vacuum state 5Pa.
In the technical solution of the application:
Compared with the prior art, the beneficial effects of the present invention are:
(1) in the technical solution of the application, fresh middle river red sage root item is first excavated, selects that quality is good and robust growth
Root item removes the silt on Radix Salviae Miltiorrhizae surface by cleaning and is stained, and draining and the moisture on root surface is dried after cleaning, by Radix Salviae Miltiorrhizae
Root item is put into microtome, and the Danshen Tablets after slice are put into sterile tray and are put neatly, and this pallet is put into freeze-drying
Machine, and 17 stage runnings are set, total time-consuming 60.05-90.05 hours, preceding 10 stages were cooling icing stage, rear 7 ranks
Section is the temperature rise period, and cooperates vacreation, can be absolutely in the effect of cooperation vacuum by the stage of low temperature to room temperature
The effective component for lockking Radix Salviae Miltiorrhizae, not will cause loss, and cryogenic freezing adds the drying compared with normal temperature, kill effective component will not
Extremely, in addition, having cooperated low temperature, vacuum and the bactericidal effect compared with room temperature, the Danshen Tablets quality of production is high, after processing is completed by product
It is put into vacuum tank and saves；
(2) the application is cold using vacuum in the case where guaranteeing that its active constituent is constant according to the biological nature of river Radix Salviae Miltiorrhizae
Freeze dry technology to be dried, the Danshen Tablets after drying can keep original physiological activity to greatest extent, make contained by it
The various natural function ingredients having obtain maximum protection in the drying process, can not only keep natural shape but also its sense organ can be improved
Quality.
(3) Danshen Tablets of the new machining method production of the application river Radix Salviae Miltiorrhizae are of light color, and dry product, which enters water 8 minutes just, can become fresh
Product apperance, the Danshen Tablets of produced in conventional processes have apparent sundries and a foam, and the Danshen Tablets of the application are and soaked without any sundries
After float on surface layer, it is in good taste；
(4) it is 60% that the Radix Salviae Miltiorrhizae finished product water solubility that the present invention processes, which includes overflow,.
(5) the above red sage root robust growth of level-one, quality is high, facilitates slice and following process；
(6) nutrient loss is minimum after the Danshen Tablets processing of 1.85mm thickness, and will not generate impurity, in process
Loss is minimum, furthermore facilitates slice, too thin bad slice, and too thick freeze-drying is not thorough；
(7) by under -50 DEG C of low temperature, can first lock the nutrition of Danshen Tablets rapidly, after freezing a period of time successively uniformly
Temperature is turned up, respectively -40 DEG C, -35 DEG C, -30 DEG C, -20 DEG C, -15 DEG C, -10 DEG C and -5 DEG C are to 0 DEG C, until temperature is increased to
30 DEG C, and cooperate different vacuum states in the process to sterilize, under vacuum conditions, most of microorganism is due to no oxygen apnea
Extremely, that is, it sterilizes, furthermore under the conditions of negative pressure of vacuum, the boiling point of the moisture in Radix Salviae Miltiorrhizae is down to lower temperature and starts to evaporate, and plays very
Good desiccation.
Specific embodiment
It is right combined with specific embodiments below in order to make those skilled in the art more fully understand technical solution of the present invention
The present invention is described in further detail.
Embodiment 1
A kind of new machining method of river Radix Salviae Miltiorrhizae, comprising the following steps:
(1) fresh middle river red sage root item is excavated；
(2) red sage root item is selected；The standard for selecting red sage root item is to select the above red sage root item of level-one, i.e., diameter is in 0.7-
Red sage root item between 1.2cm；
(3) it cleans；
(4) Danshen Tablets are sliced to obtain to the red sage root item after cleaning；Radix Salviae Miltiorrhizae after cleaning is put into microtome with item, it is red
Join piece with a thickness of 1.35mm；
(6) Danshen Tablets are freeze-dried；
(7) freeze-drying is divided into 17 stage runnings, and preceding 10 stages are the cooling icing stages, and rear 7 stages are heating
Stage, and cooperate vacreation, total time-consuming 60.05 hours；17 stages are respectively to freeze in the 1st stage in order, 1 at -50 DEG C
Hour, vacuum state 0Pa；2nd stage vacuumized, 0.5 hour at -50 DEG C, vacuum state 10Pa；3rd stage started to rise
China, 1.05 hours at -40 DEG C, vacuum state 10Pa；4th stage distilled, 1.05 hours at -35 DEG C, vacuum state 10Pa；
5th stage distilled, 1.05 hours at -30 DEG C, vacuum state 10Pa；6th stage distilled, 1.05 hours at -25 DEG C, vacuum shape
State is 10Pa；7th stage distilled, 1.05 hours at -20 DEG C, vacuum state 10Pa；8th stage distilled, and 2.05 is small at -15 DEG C
When, vacuum state 10Pa；9th stage distilled, 1.05 hours at -10 DEG C, vacuum state 10Pa；The distillation of 10th stage, -5
3.05 hours at DEG C, vacuum state 10Pa；11st stage distilled, 3.05 hours at 0 DEG C, vacuum state 10Pa；12nd rank
Duan Shenghua, 1.05 hours at 5 DEG C, vacuum state 10Pa；13rd stage distilled, and 1.05 hours at 10 DEG C, vacuum state is
10Pa；14th stage distilled, 3 hours at 15 DEG C, vacuum state 10Pa；15th stage distilled, 4 hours at 20 DEG C, vacuum shape
State is 10Pa；16th stage distilled, 7 hours at 25 DEG C, vacuum state 5Pa；17th stage distilled, 28 hours at 30 DEG C, very
Dummy status is 5Pa.
The Danshen Tablets of the present embodiment are of light color, and dry product, which enters water 8 minutes, just can become fresh goods apperance, the pellet of produced in conventional processes
Ginseng piece has apparent sundries and a foam, the Danshen Tablets of the present embodiment without any sundries, and it is soaked after float on surface layer, it is in good taste, it is red
It is 60% that ginseng finished product water solubility, which includes overflow,.
Embodiment 2
A kind of new machining method of river Radix Salviae Miltiorrhizae, comprising the following steps:
(1) fresh middle river red sage root item is excavated；
(2) red sage root item is selected；The standard for selecting red sage root item is to select the above red sage root item of level-one, i.e., diameter is in 0.7-
Red sage root item between 1.2cm；
(3) it cleans；
(4) Danshen Tablets are sliced to obtain to the red sage root item after cleaning；Radix Salviae Miltiorrhizae after cleaning is put into microtome with item, it is red
Join piece with a thickness of 1.85mm；
(6) Danshen Tablets are freeze-dried；
(7) freeze-drying is divided into 17 stage runnings, and preceding 10 stages are the cooling icing stages, and rear 7 stages are heating
Stage, and cooperate vacreation, total time-consuming 75.05 hours；17 stages are respectively to freeze in the 1st stage in order, at -50 DEG C
1.5 hours, vacuum state 0Pa；2nd stage vacuumized, 1 hour at -50 DEG C, vacuum state 7Pa；3rd stage started to rise
China, 2.05 hours at -40 DEG C, vacuum state 7Pa；4th stage distilled, 2.05 hours at -35 DEG C, vacuum state 7Pa；The
5 stages distilled, 2.05 hours at -30 DEG C, vacuum state 7Pa；6th stage distilled, 1.55 hours at -25 DEG C, vacuum state
For 7Pa；7th stage distilled, 1.55 hours at -20 DEG C, vacuum state 7Pa；8th stage distilled, 2.55 hours at -15 DEG C,
Vacuum state is 7Pa；9th stage distilled, 1.55 hours at -10 DEG C, vacuum state 7Pa；10th stage distilled, at -5 DEG C
4.05 hours, vacuum state 7Pa；11st stage distilled, 4.05 hours at 0 DEG C, vacuum state 7Pa；The distillation of 12nd stage,
2.05 hours at 5 DEG C, vacuum state 7Pa；13rd stage distilled, 2.05 hours at 10 DEG C, vacuum state 7Pa；14th rank
Duan Shenghua, 4 hours at 15 DEG C, vacuum state 7Pa；15th stage distilled, 5 hours at 20 DEG C, vacuum state 7Pa；16th
Stage distils, 8 hours at 25 DEG C, vacuum state 5Pa；17th stage distilled, 30 hours at 30 DEG C, vacuum state 5Pa.
The Danshen Tablets of the present embodiment are of light color, and dry product, which enters water 8 minutes, just can become fresh goods apperance, the pellet of produced in conventional processes
Ginseng piece has apparent sundries and a foam, the Danshen Tablets of the present embodiment without any sundries, and it is soaked after float on surface layer, it is in good taste, it is red
It is 60% that ginseng finished product water solubility, which includes overflow,.
Embodiment 3
A kind of new machining method of river Radix Salviae Miltiorrhizae, comprising the following steps:
(1) fresh middle river red sage root item is excavated；
(2) red sage root item is selected；The standard for selecting red sage root item is to select the above red sage root item of level-one, i.e., diameter is in 0.7-
Red sage root item between 1.2cm；
(3) it cleans；
(4) Danshen Tablets are sliced to obtain to the red sage root item after cleaning；Radix Salviae Miltiorrhizae after cleaning is put into microtome with item, it is red
Join piece with a thickness of 2.35mm；
(6) Danshen Tablets are freeze-dried；
(7) freeze-drying is divided into 17 stage runnings, and preceding 10 stages are the cooling icing stages, and rear 7 stages are heating
Stage, and cooperate vacreation, total time-consuming 90.05 hours；17 stages are respectively to freeze in the 1st stage in order, 2 at -50 DEG C
Hour, vacuum state 0Pa；2nd stage vacuumized, 1.5 hours at -50 DEG C, vacuum state 5Pa；3rd stage started to rise
China, 3.05 hours at -40 DEG C, vacuum state 5Pa；4th stage distilled, 3.05 hours at -35 DEG C, vacuum state 5Pa；The
5 stages distilled, 3.05 hours at -30 DEG C, vacuum state 5Pa；6th stage distilled, 2.05 hours at -25 DEG C, vacuum state
For 5Pa；7th stage distilled, 2.05 hours at -20 DEG C, vacuum state 5Pa；8th stage distilled, 3.05 hours at -15 DEG C,
Vacuum state is 5Pa；9th stage distilled, 2.05 hours at -10 DEG C, vacuum state 5Pa；10th stage distilled, at -5 DEG C
5.05 hours, vacuum state 5Pa；11st stage distilled, 5.05 hours at 0 DEG C, vacuum state 5Pa；The distillation of 12nd stage,
3.05 hours at 5 DEG C, vacuum state 5Pa；13rd stage distilled, 3.05 hours at 10 DEG C, vacuum state 5Pa；14th rank
Duan Shenghua, 5 hours at 15 DEG C, vacuum state 5Pa；15th stage distilled, 6 hours at 20 DEG C, vacuum state 5Pa；16th
Stage distils, 9 hours at 25 DEG C, vacuum state 5Pa；17th stage distilled, 32 hours at 30 DEG C, vacuum state 5Pa.
The Danshen Tablets of the present embodiment are of light color, and dry product, which enters water 8 minutes, just can become fresh goods apperance, the pellet of produced in conventional processes
Ginseng piece has apparent sundries and a foam, the Danshen Tablets of the present embodiment without any sundries, and it is soaked after float on surface layer, it is in good taste, it is red
It is 60% that ginseng finished product water solubility, which includes overflow,.
Test example
The embodiment 1-3 Danshen Tablets processed are sent to Deyang City food and drug safety and examine inspection center's detection, detection is total
Ash content, moisture, impurity, tanshinone and tanshin polyphenolic acid B, testing result are as shown in table 1.
The content of each ingredient of Danshen Tablets of 1 embodiment 1-3 of table processing
In this test example, the Radix Salviae Miltiorrhizae product of each embodiment presses DB510623/T 19-2014；Referring to " Chinese Pharmacopoeia " 2015
One above-mentioned project of detection of version.
There is detection add it is found that the total ash content of embodiment 1-3 comply with standard it is defined should must not cross 6.0% mark
It is quasi-；The moisture content of embodiment 1-3 comply with standard as defined in should must not exceed 13.0% standard；The impurity of embodiment 1-3
Content is 0, meet impurity should must not cross 5.0% standard；The content of the tanshinone of embodiment 1-3 meets total amount must not
Standard less than 0.25%；The standard that the content of the tanshin polyphenolic acid B of embodiment 1-3 must not meet less than 5.0%.
Wherein, tanshinone includes Tanshinone I IA, Cryptotanshinone and Tanshinone I.
The specific embodiment of the application above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
The limitation to the application protection scope therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, under the premise of not departing from technical scheme design, various modifications and improvements can be made, these belong to this
The protection scope of application.
Claims (6)
1. a kind of new machining method of river Radix Salviae Miltiorrhizae, which comprises the following steps:
(1) fresh middle river red sage root item is excavated；
(2) red sage root item is selected；
(3) it cleans；
(4) Danshen Tablets are sliced to obtain to the red sage root item after cleaning；
(6) Danshen Tablets are freeze-dried；
(7) freeze-drying is divided into 17 stage runnings, and preceding 10 stages are the cooling icing stages, and rear 7 stages are the temperature rise period,
And cooperate vacreation, total time-consuming 60.05-90.05 hours.
2. a kind of new machining method of river Radix Salviae Miltiorrhizae according to claim 1, which is characterized in that step (2) selects red sage root item
Standard be to select the above red sage root item of level-one, i.e. red sage root item of the diameter between 0.7-1.2cm.
3. a kind of new machining method of river Radix Salviae Miltiorrhizae according to claim 1, which is characterized in that after being cleaned in step (4)
Radix Salviae Miltiorrhizae be put into microtome with item, Danshen Tablets with a thickness of 1.35-2.35mm.
4. according to a kind of new machining method for river Radix Salviae Miltiorrhizae that claim 3 is stated, which is characterized in that Danshen Tablets with a thickness of
1.85mm。
5. a kind of new machining method of river Radix Salviae Miltiorrhizae according to claim 1, which is characterized in that 17 stages in step (7)
It is in order respectively to freeze in the 1st stage, 1-2 hours at -50 DEG C, vacuum state 0Pa；2nd stage vacuumized, at -50 DEG C
0.5-1.5 hours, vacuum state 5-10Pa；3rd stage started to distil, and 1.05-3.05 hours at -40 DEG C, vacuum state is
5-10Pa；4th stage distilled, 1.05-3.05 hours at -35 DEG C, vacuum state 5-10Pa；5th stage distilled, at -30 DEG C
1.05-3.05 hours, vacuum state 5-10Pa；6th stage distilled, 1.05-2.05 hours at -25 DEG C, vacuum state 5-
10Pa；7th stage distilled, 1.05-2.05 hours at -20 DEG C, vacuum state 5-10Pa；8th stage distilled, at -15 DEG C
2.05-3.05 hours, vacuum state 5-10Pa；9th stage distilled, 1.05-2.05 hours at -10 DEG C, vacuum state 5-
10Pa；10th stage distilled, 3.05-5.05 hours at -5 DEG C, vacuum state 5-10Pa；11st stage distilled, at 0 DEG C
3.05-5.05 hours, vacuum state 5-10Pa；12nd stage distilled, 1.05-3.05 hours at 5 DEG C, vacuum state 5-
10Pa；13rd stage distilled, 1.05-3.05 hours at 10 DEG C, vacuum state 5-10Pa；14th stage distilled, 3-5 at 15 DEG C
Hour, vacuum state 5-10Pa；15th stage distilled, 4-6 hours at 20 DEG C, vacuum state 5-10Pa；16th stage liter
China, 7-9 hours at 25 DEG C, vacuum state 5Pa；17th stage distilled, 28-32 hours at 30 DEG C, vacuum state 5Pa.
6. a kind of new machining method of river Radix Salviae Miltiorrhizae according to claim 5, which is characterized in that 17 stages in step (7)
It is in order respectively to freeze in the 1st stage, 1.5 hours at -50 DEG C, vacuum state 0Pa；2nd stage vacuumized, and 1 is small at -50 DEG C
When, vacuum state 7Pa；3rd stage started to distil, 2.05 hours at -40 DEG C, vacuum state 7Pa；The distillation of 4th stage ,-
2.05 hours at 35 DEG C, vacuum state 7Pa；5th stage distilled, 2.05 hours at -30 DEG C, vacuum state 7Pa；6th rank
Duan Shenghua, 1.55 hours at -25 DEG C, vacuum state 7Pa；7th stage distilled, and 1.55 hours at -20 DEG C, vacuum state is
7Pa；8th stage distilled, 2.55 hours at -15 DEG C, vacuum state 7Pa；9th stage distilled, 1.55 hours at -10 DEG C, very
Dummy status is 7Pa；10th stage distilled, 4.05 hours at -5 DEG C, vacuum state 7Pa；11st stage distilled, 4.05 at 0 DEG C
Hour, vacuum state 7Pa；12nd stage distilled, 2.05 hours at 5 DEG C, vacuum state 7Pa；The distillation of 13rd stage, 10 DEG C
Lower 2.05 hours, vacuum state 7Pa；14th stage distilled, 4 hours at 15 DEG C, vacuum state 7Pa；The distillation of 15th stage,
5 hours at 20 DEG C, vacuum state 7Pa；16th stage distilled, 8 hours at 25 DEG C, vacuum state 5Pa；17th stage liter
China, 30 hours at 30 DEG C, vacuum state 5Pa.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113137835A (en) * | 2021-05-18 | 2021-07-20 | 甘肃省方熙药业科技有限公司 | Lithospermum erythrorhizon drying processing method |
| CN113251749A (en) * | 2021-05-18 | 2021-08-13 | 甘肃省方熙药业科技有限公司 | Method for freeze drying salvia miltiorrhiza |
-
2019
- 2019-06-20 CN CN201910535936.7A patent/CN110151819A/en active Pending
Non-Patent Citations (1)
| Title |
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| 徐成海等: "《真空低温技术与设备》", 30 September 2007, 冶金工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113137835A (en) * | 2021-05-18 | 2021-07-20 | 甘肃省方熙药业科技有限公司 | Lithospermum erythrorhizon drying processing method |
| CN113251749A (en) * | 2021-05-18 | 2021-08-13 | 甘肃省方熙药业科技有限公司 | Method for freeze drying salvia miltiorrhiza |
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