CN110124061A - Effervescent tablet is preparing application in gastrointestinal examination capsule and including its gastrointestinal examination capsule - Google Patents
Effervescent tablet is preparing application in gastrointestinal examination capsule and including its gastrointestinal examination capsule Download PDFInfo
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- CN110124061A CN110124061A CN201910520429.6A CN201910520429A CN110124061A CN 110124061 A CN110124061 A CN 110124061A CN 201910520429 A CN201910520429 A CN 201910520429A CN 110124061 A CN110124061 A CN 110124061A
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- agent
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- effervescent tablet
- sour
- alkaline agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
- A61B1/2736—Gastroscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
Abstract
The present invention provides a kind of effervescent tablets to prepare application in gastrointestinal examination capsule and including its gastrointestinal examination capsule, be related to medical new material technology field.The effervescent tablet is mainly made by alkaline agent, sour agent and functional auxiliary material, and the mass ratio of the acid agent and alkaline agent is (1.1~1.3): 1, the dissolution pH value of the effervescent tablet is 6.5~7.5.The disintegrating agent of above-mentioned acid agent and alkaline agent as effervescent tablet, after above-mentioned extra fine quality ratio compounding, which can just be disintegrated rapidly only under the specific pH value condition of small intestine, generate a large amount of carbon dioxide.After being filled with the detection capsule equipped with microcam, when capsule enters small intestine, motive force is formed after Effervescent tablet disintegration, the caping of detection capsule can be opened, miniature electronic video camera is started to work, particular detection is carried out to small intestine to realize, existing enterogastric diseases is alleviated and checks existing technological difficulties.
Description
Technical field
The present invention relates to medical new material technology fields, are preparing gastrointestinal examination capsule more particularly, to a kind of effervescent tablet
In application and including its gastrointestinal examination capsule.
Background technique
The disease examination of gastrointestinal tract is the very painful thing of patient, and due to the limitation of present medical level, enteroscopy is big
Large intestine is mostly inserted into fiber hose, checks the lesion at enteron aisle position.But since enteron aisle inside fold is more, fiber hose is entered
It is difficult to be further continued for after certain position, brings great difficulty to inspection.Although also occurring one in existing technical solution
A little capsules equipped with miniature webcam for gastrointestinal tract detection, but existing this kind of capsule is mainly used for stomach or large intestine
Detection applies the detection of small intestine limited.
Therefore, a kind of effervescent tablet is researched and developed, the effervescent tablet is only when reaching small intestine, just in the specific of small intestine enteron aisle
It is disintegrated under the conditions of pH, the carbon dioxide gas cognition generated in disintegrating procedue opens the caping of capsule, and miniature electronic video camera starts
Work becomes very necessary and urgent to achieve the purpose that carry out particular detection to small intestine.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of effervescent tablet and is preparing the application in gastrointestinal examination capsule, the bubble
It rises piece to be mainly made by alkaline agent, sour agent and functional auxiliary material, the mass ratio of the acid agent and alkaline agent is (1.1~1.3): 1, it is described
The dissolution pH value of effervescent tablet is 6.5~7.5.The disintegrating agent of above-mentioned acid agent and alkaline agent as effervescent tablet, with above-mentioned extra fine quality ratio
Effervescent tablet obtained only can be just disintegrated rapidly under the specific pH value condition of small intestine after compounding, generate a large amount of carbon dioxide.
The second object of the present invention is to provide a kind of gastrointestinal examination capsule, and the gastrointestinal examination capsule includes above-mentioned
What is be prepared is used to prepare the effervescent tablet of gastrointestinal examination capsule, which can be used for the detection of small intestine.
A kind of effervescent tablet provided by the invention is preparing the application in gastrointestinal examination capsule, and the effervescent tablet is mainly by alkali
Agent, sour agent and functional auxiliary material are made；
The mass ratio of the acid agent and alkaline agent is (1.1~1.3): 1.
The dissolution pH value of the effervescent tablet is 6.5~7.5.
Further, the mass ratio of the sour agent and alkaline agent is (1.1~1.2): 1；
Preferably, the mass ratio of the sour agent and alkaline agent is 1.2:1.
Preferably, the dissolution pH value of the effervescent tablet is 6.8~7.2；
Preferably, the dissolution pH value of the effervescent tablet is 7.
Further, the sour agent is one of citric acid, tartaric acid, malic acid and fumaric acid；
Preferably, the sour agent is citric acid.
Further, the alkaline agent is sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, saleratus and calcium bicarbonate
One of；
Preferably, the alkaline agent is saleratus.
Further, the functional auxiliary material includes sour agent filler, alkaline agent filler, adhesive and whole grain agent；
Preferably, the sour agent filler is maltodextrin；
Preferably, the alkaline agent filler is lactose；
Preferably, described adhesive is the ethanol solution containing 10% PVP K30；
Preferably, the whole grain agent includes magnesium stearate and polyethylene glycol.
Further, according to the mass fraction, the effervescent tablet is mainly made of the following raw material: 25 parts of alkaline agent, sour agent 27~
32 parts, sour 18~20 parts of agent filler, 11~14 parts of alkaline agent filler, 0.5~1.5 part of adhesive, 11~14 parts of magnesium stearate and poly-
0.2~0.5 part of ethylene glycol.
Further, according to the mass fraction, the effervescent tablet is mainly made of the following raw material: 23~27 parts of alkaline agent, sour agent
30 parts, sour 18~20 parts of agent filler, 11~14 parts of alkaline agent filler, 0.5~1.5 part of adhesive, 11~14 parts of magnesium stearate and poly-
0.2~0.5 part of ethylene glycol.
Further, according to the mass fraction, the effervescent tablet is mainly made of the following raw material: 25 parts of alkaline agent, sour agent 30
Part, sour 19.75 parts of agent filler, 12.5 parts of alkaline agent filler, 0.5 part of adhesive, 12.5 parts of magnesium stearate and 0.25 part of polyethylene glycol.
Further, the effervescent tablet preparation method the following steps are included:
(a), adhesive is divided into two parts, obtains adhesive A and adhesive B；
(b), alkaline agent, alkaline agent filler and adhesive A are mixed, obtains alkaline agent mixture；
(c), sour agent, sour agent filler and adhesive B are mixed, obtains sour agent mixture；
(d), sour agent mixture, magnesium stearate and the poly- second for obtaining alkaline agent mixture that step (b) obtains, step (c)
Uniformly compacting obtains effervescent tablet to glycol afterwards；
The sequence interchangeable of the step (b) and step (c).
A kind of gastrointestinal examination capsule provided by the invention, the gastrointestinal examination capsule include above-mentioned being used to prepare stomach and intestine
The effervescent tablet of road inspection capsule.
Compared with prior art, the invention has the benefit that
Effervescent tablet provided by the invention is preparing the application in gastrointestinal examination capsule, the effervescent tablet mainly by alkaline agent,
Sour agent and functional auxiliary material are made, and the mass ratio of the acid agent and alkaline agent is (1.1~1.3): 1.Above-mentioned acid agent and alkaline agent conduct
The disintegrating agent of effervescent tablet, with above-mentioned extra fine quality than effervescent tablet obtained after compounding only under the specific pH value condition of small intestine
It can be disintegrated rapidly, generate a large amount of carbon dioxide, and then form motive force, the caping of detection capsule is opened, miniature electronic camera shooting
Machine is started to work, to realize detection.
A kind of gastrointestinal examination capsule provided by the invention, the gastrointestinal examination capsule include the effervesce in above-mentioned application
Piece, the gastrointestinal examination capsule can be widely applied to the detection of gastrointestinal tract.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the effervescent tablet preparation technology flow chart of the present invention that an embodiment of the present invention 10 provides.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality
Applying example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
According to an aspect of the present invention, a kind of effervescent tablet is preparing the application in gastrointestinal examination capsule, the effervesce
Piece is mainly made by alkaline agent, sour agent and functional auxiliary material；
The mass ratio of the acid agent and alkaline agent is (1.1~1.3): 1.
Effervescent tablet provided by the invention is preparing the application in gastrointestinal examination capsule, the effervescent tablet mainly by alkaline agent,
Sour agent and functional auxiliary material are made, and the mass ratio of the acid agent and alkaline agent is (1.1~1.3): 1.Above-mentioned acid agent and alkaline agent conduct
The disintegrating agent of effervescent tablet, with above-mentioned extra fine quality than effervescent tablet obtained after compounding only under the specific pH value condition of small intestine
It can be disintegrated rapidly, generate a large amount of carbon dioxide, and then form motive force, the caping of detection capsule is opened, miniature electronic camera shooting
Machine is started to work, and carries out particular detection to small intestine to realize.
In the preferred embodiment of the present invention, the mass ratio of the sour agent and alkaline agent is (1.1~1.2): 1；
Preferably, the mass ratio of the sour agent and alkaline agent is 1.2:1.
As a preferred embodiment, effervescent tablet obtained can when the mass ratio of above-mentioned acid agent and alkaline agent is 1.2:1
To dissolve in the case where pH is 6.5~7.5 environment (the pH environment of small intestine), carbon dioxide gas production is equivalent to effervescent tablet volume multiple
2.2~3.2 times.
In the preferred embodiment of the present invention, the sour agent is in tartaric acid, citric acid, fumaric acid and malic acid
One kind；
Preferably, the sour agent is citric acid.
In above-mentioned preferred embodiment, when sour agent is citric acid, the Effervescent tablet disintegration speed being prepared is fast, dissolves
Solution afterwards is also more stable.
In the preferred embodiment of the present invention, the alkaline agent be potassium carbonate, sodium carbonate, sodium bicarbonate, calcium carbonate,
One of saleratus and calcium bicarbonate；
Preferably, the alkaline agent is saleratus.
In above-mentioned preferred embodiment, when alkaline agent is saleratus, the Effervescent tablet disintegration speed being prepared is fast, molten
Solution after solution is more stable.
In the preferred embodiment of the present invention, the functional auxiliary material includes alkaline agent filler, sour agent filler, whole grain
Agent and adhesive；
Preferably, the alkaline agent filler is lactose, and the acid agent filler is maltodextrin；
Select excellent embodiment as a kind of, when maltodextrin and lactose are as filler, can make effervescent tablet forming,
It is dispersed evenly and stably after dissolution, disintegration rate is fast, without sticking.
Preferably, described adhesive is the ethanol solution containing 10% PVP K30.
As a preferred embodiment, above-mentioned adhesive is the ethanol solution containing 10% PVP K30, povidone
K30 is widely used in pharmaceutical field as a kind of adhesive, is international one of the 3 big new auxiliary materials of pharmacy advocated, has dosage
Few, non-stimulated to body advantage.
Preferably, the whole grain agent includes magnesium stearate and polyethylene glycol.
As a preferred embodiment, the preparation process of above-mentioned magnesium stearate and polyethylene glycol in effervescent tablet of the present invention
In play the role of the whole grain before tabletting.
It is furthermore preferred that the polyethylene glycol is Macrogol 6000.
In the preferred embodiment of the present invention, according to the mass fraction, the effervescent tablet is mainly by the following raw material system
At: 25 parts of alkaline agent, sour 27~32 parts of agent, sour 18~20 parts of agent filler, 11~14 parts of alkaline agent filler, 0.5~1.5 part of adhesive,
11~14 parts and 0.2~0.5 part of polyethylene glycol of magnesium stearate.
As a preferred embodiment, above-mentioned alkaline agent filler is typical but unrestricted when the content of alkaline agent is 25 parts
The preferred embodiment of property are as follows: 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts and 14 parts；Above-mentioned acid agent is typical but non-
Restrictive preferred embodiment are as follows: 27 parts, 28 parts, 29 parts, 30 parts, 31 parts and 32 parts；Above-mentioned adhesive is typical but unrestricted
The preferred embodiment of property are as follows: 0.5 part, 0.8 part, 1.0 parts, 1.2 parts and 1.5 parts；Above-mentioned acid agent filler is typical but non-limiting
Preferred embodiment are as follows: 18 parts, 18.5 parts, 19 parts, 19.5 and 20 parts；Above-mentioned magnesium stearate is typical but non-limiting preferably
Embodiment are as follows: 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts and 14 parts；Above-mentioned polyethylene glycol is typical but unrestricted
The preferred embodiment of property are as follows: 0.2 part, 0.3 part, 0.4 part and 0.5 part.
In the preferred embodiment of the present invention, according to the mass fraction, the effervescent tablet is mainly by the following raw material system
At: 23~27 parts of alkaline agent, sour 30 parts of agent, sour 18~20 parts of agent filler, 11~14 parts of alkaline agent filler, 0.5~1.5 part of adhesive,
11~14 parts and 0.2~0.5 part of polyethylene glycol of magnesium stearate.
As a preferred embodiment, above-mentioned alkaline agent is typical but non-limiting when the content of sour agent is 30 parts
Preferred embodiment are as follows: 23 parts, 24 parts, 25 parts, 26 parts and 27 parts；The above-mentioned typical but non-limiting preferred implementation of alkaline agent filler
Scheme are as follows: 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts and 14 parts；Above-mentioned acid agent filler is typical but non-limiting
Preferred embodiment are as follows: 18 parts, 18.5 parts, 19 parts, 19.5 and 20 parts；The above-mentioned typical but non-limiting preferred reality of magnesium stearate
Apply scheme are as follows: 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts and 14 parts；Above-mentioned adhesive is typical but non-limiting
Preferred embodiment are as follows: 0.5 part, 0.8 part, 1.0 parts, 1.2 parts and 1.5 parts；Above-mentioned polyethylene glycol is typical but non-limiting excellent
Select embodiment are as follows: 0.2 part, 0.3 part, 0.4 part and 0.5 part.
In above-mentioned preferred embodiment, according to the mass fraction, the effervescent tablet is mainly made of the following raw material: alkaline agent 25
Part, sour 30 parts of agent, sour 19.75 parts of agent filler, 12.5 parts of alkaline agent filler, 0.5 part of adhesive, 12.5 parts of magnesium stearate and poly- second two
0.25 part of alcohol.
In the present invention, by the further adjustment and optimization to each component raw material dosage ratio, to advanced optimize
The carbon dioxide of effervescent tablet of the present invention produces gas effect and motive force.
In the preferred embodiment of the present invention, the effervescent tablet preparation method the following steps are included:
(a), adhesive is divided into two parts, obtains adhesive A and adhesive B；
(b), alkaline agent, alkaline agent filler and adhesive A are mixed, obtains alkaline agent mixture；
(c), sour agent, sour agent filler and adhesive B are mixed, obtains sour agent mixture；
(d), sour agent mixture, magnesium stearate and the poly- second for obtaining alkaline agent mixture that step (b) obtains, step (c)
Uniformly compacting obtains effervescent tablet to glycol afterwards；
The sequence interchangeable of the step (b) and step (c).
In the preferred embodiment of the present invention, the mixture in the step (b) and step (c) can be warp
The particle that drying and granulating obtains；
Preferably, the drying time of the drying and granulating is 0.5~1 hour, and drying temperature is 50~60 DEG C.
Preferably, the effervescent tablet preparation method specifically includes the following steps:
(I), saleratus, citric acid, lactose and maltodextrin are crushed respectively be 80 meshes fine powder；
(II), smashed saleratus and lactose are mixed 3~5 minutes, obtains mixed powder 1, half matter is then added
The adhesive for measuring number, obtains softwood 1 after mixing；Then softwood is crossed by 30 meshes using the method for wet granulation and wet granular is made
1；It is finally 0.5~1 hour dry at 50~60 DEG C, dry particl 1 is obtained after whole grain；
(III), smashed citric acid and maltodextrin are mixed 3~5 minutes, obtains mixed powder 2, half is then added
The adhesive of mass fraction obtains softwood 2 after mixing；Then softwood is crossed by 30 meshes using the method for wet granulation and is made wet
Grain 2；It is finally 0.5~1 hour dry at 50~60 DEG C, dry particl 2 is obtained after whole grain；
The sequence interchangeable of the step (II) and step (III).
(IV), by dry particl 1, dry particl 2, magnesium stearate and polyethylene glycol it is uniform after through compacting obtain effervescent tablet.
Preferably, the compacting specification of the effervescent tablet is 3~5mm of diameter, 3~6mm of piece thickness, 20~50mg of slice weight.
A kind of gastrointestinal examination capsule provided by the invention, the gastrointestinal examination capsule include the above-mentioned use being prepared
In the effervescent tablet for preparing gastrointestinal examination capsule, which can be widely applied to the small intestine in gastrointestinal tract detection
Detection.
Technical solution of the present invention is described further below in conjunction with embodiment and comparative example.
Embodiment 1
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 25 parts of sodium carbonate, winestone
27 parts of acid, 18 parts of maltodextrin, 11 parts of lactose, 11 parts of 0.5 part of ethanol solution, magnesium stearate containing 10% PVP K30 and poly-
0.2 part of ethylene glycol.
Embodiment 2
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 25 parts of potassium carbonate, apple
32 parts of acid, 20 parts of maltodextrin, 14 parts of lactose, 14 parts of 1.5 parts of ethanol solution, magnesium stearate containing 10% PVP K30 and poly-
0.5 part of ethylene glycol.
Embodiment 3
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 25 parts of calcium carbonate, rich horse
27 parts of acid, 18 parts of maltodextrin, 11 parts of lactose, 11 parts of 0.5 part of ethanol solution, magnesium stearate containing 10% PVP K30 and poly-
0.2 part of ethylene glycol.
Embodiment 4
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 25 parts of sodium bicarbonate, lemon
Lemon acid 32 parts, 20 parts of maltodextrin, 14 parts of lactose, 14 parts of 0.5 part of ethanol solution, magnesium stearate containing 10% PVP K30 and
0.5 part of polyethylene glycol.
Embodiment 5
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 25 parts of saleratus, lemon
Lemon acid 27 parts, 18 parts of maltodextrin, 11 parts of lactose, 11 parts of 0.5 part of ethanol solution, magnesium stearate containing 10% PVP K30 and
0.2 part of polyethylene glycol.
Embodiment 6
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 25 parts of saleratus, lemon
Lemon acid 32 parts, 20 parts of maltodextrin, 14 parts of lactose, 14 parts of 0.5 part of ethanol solution, magnesium stearate containing 10% PVP K30 and
0.5 part of polyethylene glycol.
Embodiment 7
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 23 parts of saleratus, lemon
Lemon acid 30 parts, 19 parts of maltodextrin, 12 parts of lactose, 12 parts of 0.5 part of ethanol solution, magnesium stearate containing 10% PVP K30 and
0.3 part of polyethylene glycol.
Embodiment 8
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 27 parts of saleratus, lemon
Lemon acid 30 parts, 19 parts of maltodextrin, 13 parts of lactose, 13 parts of 0.5 part of ethanol solution, magnesium stearate containing 10% PVP K30 and
0.4 part of polyethylene glycol.
Embodiment 9
A kind of effervescent tablet, according to the mass fraction, the effervescent tablet are mainly made of the following raw material: 25 parts of saleratus, lemon
Lemon acid 30 parts, 19.75 parts of maltodextrin, 12.5 parts of lactose, 0.5 part of ethanol solution, magnesium stearate containing 10% PVP K30
12.5 parts and 0.25 part of polyethylene glycol.
Comparative example 1
This comparative example is in addition to the content of saleratus is 22 parts by weight, remaining is the same as embodiment 9.
Comparative example 2
This comparative example is in addition to the content of saleratus is 29 parts by weight, remaining is the same as embodiment 9.
Comparative example 3
This comparative example is in addition to the content of citric acid is 34 parts by weight, remaining is the same as embodiment 9.
Comparative example 4
This comparative example is in addition to the content of citric acid is 25 parts by weight, remaining is the same as embodiment 9.
Embodiment 10
The preparation method of effervescent tablet described in above-described embodiment 1~9 and comparative example 1~4, specifically includes the following steps:
(I), saleratus, citric acid, lactose and maltodextrin are crushed respectively be 80 meshes fine powder；
(II), smashed saleratus and lactose are mixed 3~5 minutes, obtains mixed powder 1, half matter is then added
The adhesive for measuring number, obtains softwood 1 after mixing；Then softwood is crossed by 30 meshes using the method for wet granulation and wet granular is made
1；It is finally 0.5~1 hour dry at 50~60 DEG C, dry particl 1 is obtained after whole grain；
(III), smashed citric acid and maltodextrin are mixed 3~5 minutes, obtains mixed powder 2, half is then added
The adhesive of mass fraction obtains softwood 2 after mixing；Then softwood is crossed by 30 meshes using the method for wet granulation and is made wet
Grain 2；It is finally 0.5~1 hour dry at 50~60 DEG C, dry particl 2 is obtained after whole grain；
The sequence interchangeable of the step (II) and step (III).
(IV), by dry particl 1, dry particl 2, magnesium stearate and polyethylene glycol it is uniform after be compressed to 3~5mm of diameter, piece thickness 3
The effervescent tablet of~6mm, slice weight 20~50mg specification.
Concrete technology flow process is as shown in Figure 1.
Experimental example 1
To show to have under environment (the pH environment of small intestine) that the effervescent tablet that is prepared of the present invention is 6.5~7.5 in pH
Gas effect is produced well, and the effervescent tablet that embodiment 5~9 and comparative example 1~4 is prepared in inventor has carried out performance survey
Examination, result are as shown in the table:
In conclusion effervescent tablet of the present invention is mainly made by alkaline agent, sour agent and functional auxiliary material, the acid agent and alkaline agent
Mass ratio is (1.1~1.3): 1.The disintegrating agent of above-mentioned acid agent and alkaline agent as effervescent tablet, after above-mentioned extra fine quality ratio compounding
Effervescent tablet obtained only can just generate a large amount of carbon dioxide under the specific pH value condition of small intestine is disintegrated effervescent tablet rapidly.
After being filled with the detection capsule equipped with microcam, when capsule enters small intestine, motive force is formed after Effervescent tablet disintegration,
The caping of detection capsule can be opened, miniature electronic video camera is started to work, and is carried out particular detection to small intestine to realize, is alleviated
Existing enterogastric diseases check existing technological difficulties.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. effervescent tablet is preparing the application in gastrointestinal examination capsule, which is characterized in that the effervescent tablet is mainly by alkaline agent, sour agent
It is made with functional auxiliary material；
The mass ratio of the acid agent and alkaline agent is (1.1~1.3): 1；
The dissolution pH value of the effervescent tablet is 6.5~7.5.
2. application according to claim 1, which is characterized in that the mass ratio of acid agent described in effervescent tablet and alkaline agent is (1.1
~1.2): 1；
Preferably, the mass ratio of the sour agent and alkaline agent is 1.2:1；
Preferably, the dissolution pH value of the effervescent tablet is 6.8~7.2；
Preferably, the dissolution pH value of the effervescent tablet is 7.
3. application according to claim 1 or 2, which is characterized in that it is described acid agent be citric acid, tartaric acid, malic acid and
One of fumaric acid；
Preferably, the sour agent is citric acid.
4. application according to claim 1 or 2, which is characterized in that the alkaline agent is sodium carbonate, potassium carbonate, calcium carbonate, carbon
One of sour hydrogen sodium, saleratus and calcium bicarbonate；
Preferably, the alkaline agent is saleratus.
5. application according to claim 1 or 2, which is characterized in that the functional auxiliary material is filled out including sour agent filler, alkaline agent
Material, adhesive and whole grain agent；
Preferably, the sour agent filler is maltodextrin；
Preferably, the alkaline agent filler is lactose；
Preferably, described adhesive is the ethanol solution containing 10% PVP K30；
Preferably, the whole grain agent includes magnesium stearate and polyethylene glycol.
6. application according to claim 1, which is characterized in that according to the mass fraction, the effervescent tablet is mainly by following original
Material is made: 25 parts of alkaline agent, sour 27~32 parts of agent, sour 18~20 parts of agent filler, 11~14 parts of alkaline agent filler, adhesive 0.5~1.5
Part, 11~14 parts of magnesium stearate and 0.2~0.5 part of polyethylene glycol.
7. application according to claim 1, which is characterized in that according to the mass fraction, the effervescent tablet is mainly by following original
Material is made: 23~27 parts of alkaline agent, sour 30 parts of agent, sour 18~20 parts of agent filler, 11~14 parts of alkaline agent filler, adhesive 0.5~1.5
Part, 11~14 parts of magnesium stearate and 0.2~0.5 part of polyethylene glycol.
8. application according to claim 1, which is characterized in that according to the mass fraction, the effervescent tablet is mainly by following original
Material is made: 25 parts of alkaline agent, sour 30 parts of agent, sour 19.75 parts of agent filler, 12.5 parts of alkaline agent filler, 0.5 part of adhesive, magnesium stearate
12.5 parts and 0.25 part of polyethylene glycol.
9. according to the described in any item applications of claim 6~8, which is characterized in that the preparation method of the effervescent tablet include with
Lower step:
(a), adhesive is divided into two parts, obtains adhesive A and adhesive B；
(b), alkaline agent, alkaline agent filler and adhesive A are mixed, obtains alkaline agent mixture；
(c), sour agent, sour agent filler and adhesive B are mixed, obtains sour agent mixture；
(d), sour agent mixture, magnesium stearate and the polyethylene glycol for obtaining alkaline agent mixture that step (b) obtains, step (c)
Compacting obtains effervescent tablet after mixing；
The sequence interchangeable of the step (b) and step (c).
10. a kind of gastrointestinal examination capsule, which is characterized in that the gastrointestinal examination capsule includes any one of claim 1~9
Effervescent tablet in the application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910520429.6A CN110124061B (en) | 2019-06-17 | 2019-06-17 | Application of effervescent tablets in preparation of gastrointestinal tract examination capsules and gastrointestinal tract examination capsules comprising same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2744341Y (en) * | 2004-10-25 | 2005-12-07 | 刘恒顺 | Air generation capsule for air-barium double contrast radiography of small intestine |
| CN103549434A (en) * | 2013-11-15 | 2014-02-05 | 哈尔滨艾克尔食品科技有限公司 | Making method of corn stigma effervescent tablets |
| US20140081169A1 (en) * | 2012-09-17 | 2014-03-20 | Vanderbilt University | System and method of tetherless insufflation in colon capsule endoscopy |
| CN107529965A (en) * | 2015-03-17 | 2018-01-02 | 卡普索影像公司 | Capsule apparatus with variable proportion |
| CN109043278A (en) * | 2018-07-02 | 2018-12-21 | 郑州博凯医药保健品有限公司 | Laughable taste effervescent tablet and preparation method thereof |
| CN109247906A (en) * | 2017-07-12 | 2019-01-22 | 卡普索影像公司 | For controlling the capsule enteric coating layer of balloon expandable time started |
-
2019
- 2019-06-17 CN CN201910520429.6A patent/CN110124061B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2744341Y (en) * | 2004-10-25 | 2005-12-07 | 刘恒顺 | Air generation capsule for air-barium double contrast radiography of small intestine |
| US20140081169A1 (en) * | 2012-09-17 | 2014-03-20 | Vanderbilt University | System and method of tetherless insufflation in colon capsule endoscopy |
| CN103549434A (en) * | 2013-11-15 | 2014-02-05 | 哈尔滨艾克尔食品科技有限公司 | Making method of corn stigma effervescent tablets |
| CN107529965A (en) * | 2015-03-17 | 2018-01-02 | 卡普索影像公司 | Capsule apparatus with variable proportion |
| CN109247906A (en) * | 2017-07-12 | 2019-01-22 | 卡普索影像公司 | For controlling the capsule enteric coating layer of balloon expandable time started |
| CN109043278A (en) * | 2018-07-02 | 2018-12-21 | 郑州博凯医药保健品有限公司 | Laughable taste effervescent tablet and preparation method thereof |
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