CN110123819A - It is a kind of for treating the drug and device of scar - Google Patents
It is a kind of for treating the drug and device of scar Download PDFInfo
- Publication number
- CN110123819A CN110123819A CN201910478332.3A CN201910478332A CN110123819A CN 110123819 A CN110123819 A CN 110123819A CN 201910478332 A CN201910478332 A CN 201910478332A CN 110123819 A CN110123819 A CN 110123819A
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- CN
- China
- Prior art keywords
- scar
- drug
- treating
- capsule pipe
- silicon capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3415—Trocars; Puncturing needles for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3468—Trocars; Puncturing needles for implanting or removing devices, e.g. prostheses, implants, seeds, wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Abstract
The invention belongs to field of medicine preparing technology, disclose a kind of for treating the drug and device of scar, drug is by dispelling scorching relaxed and comfortable, diphenhydramine and Botulinum toxin type A forms.Filled with the drug for treating scar in silicon capsule pipe.What the present invention used dispel scorching relaxed and comfortable, diphenhydramine and Botulinum toxin type A are all clinical common drugs, by the drug of clinical prolonged application, because drug dose very little, moreover it is inside scar, the limitation of hard fibr tissue, the disperse substantially in cicatricial tissue inside scar.The present invention is implanted into scar by silicon capsule pipe, slow release drug, three kinds of drugs can be varied in different times, scar more calm down it is rear just only bury clay with the silicon capsule pipe of diphenhydramine and Botulinum toxin type A mixed liquor can be to taking out after scar levelling, effect is calmed down in the softening for reaching scar, it avoids repeatedly the frequent of injection in scar to have an injection, the costly also very painful problem of total cost of entirely getting off.
Description
Technical field
The invention belongs to field of medicine preparing technology more particularly to a kind of for treating the drug and device of scar.
Background technique
Scar is a very general concept, it is the mode of appearance and tissue of caused skin histology after various wounds
The general designation of pathological change.It is normal, inevitable in one of wound or surface of a wound normal healing process after it is human body wound
Physiological reaction and wound healing process inevitable outcome.The essence of scar is that one kind does not have normal skin tissue's structure
And physiological function, lose normal tissue vigor, abnormal, unsound tissue.Scar has not only broken up body surface beauty, may be used also
The physiological function for interfering linked groups or organ, even results in deformity.Currently, the method for the treatment of scar have conservative treatment and
Operative treatment.One effectively method of conservative therapy is exactly the method injected in scar, and this method effect is more definite
Effect is preferable, is mainly exactly to inject glucocorticoid medicine, such as hydrocortisone, but needs injection in regular scar
It is exactly frequently to have an injection, total cost of entirely getting off is high and at the same time also very painful, in order to avoid injection pain problem, occurs in the market
Needleless injector, but be not widely applied clinically, medical fluid is by medical fluid disperse by syringe pressure in scar
In, but since keloid is very thick and hard, it is limited into the drug in scar, leverage the performance of drug effect, institute
In clinical so method to be injected in scar of taking up an official post.
In conclusion problem of the existing technology is:
Injection is more painful in existing scar, it is also necessary to which repeated multiple times injection, expense are also higher.Occurs nothing in the market
Needle applicator, but be not widely applied clinically, medical fluid be by syringe pressure by medical fluid disperse in scar, but
Be due to keloid very after and it is hard, it is limited into the drug in scar, leverage the performance of drug effect, while needleless
The design of head syringe itself and operation also have very big problem.
Solve the difficulty of above-mentioned technical problem: the maximum difficulty to solve the above problems is how could be drug without pain
Hardship is seldom painfully transported in keloid, is allowed sustained drug to play a role and is reached maximization, if it is possible to innovate one
Filling scar inside kind device prevents drug from slowly discharging, it will be able to solve common direct injection and needleless injector medicine
Bad problem is imitated, difficulty is that the selection for burying clay device and buries clay problem.
Solve the meaning of above-mentioned technical problem:
The technology solves the problems, such as that the repeated multiple times costly pain of current normal injection bring is big, also solves needleless
Drug disperses the drawback of few effect difference in head syringe scar.The technology will greatly improve the satisfaction of patient after being widely applied
Degree realizes the good target of the few inefficient fruit of expense of pain, will bring huge economic and social benefit.
Summary of the invention
In view of the problems of the existing technology, the present invention provides a kind of for treating the drug and device of scar.
The invention is realized in this way a kind of for treating the drug of scar, the drug for treating scar is dispelled inflammation
Relaxed and comfortable, diphenhydramine and Botulinum toxin type A composition；0.5% dispels 1 milliliter relaxed and comfortable inflammation, 1 milliliter of 1% diphenhydramine, Botulinum toxin type A 4 singly
Position is used as an injection units for totally 3 milliliters.
Another object of the present invention is to provide a kind of device equipped with the drug for treating scar, the dresses
It installs and is equipped with silicon capsule pipe, filled with the drug for treating scar in the silicon capsule pipe.
Further, silicon capsule pipe both ends are round blunt shape structure.
Another object of the present invention is to provide the delivery method of the drug for treating scar described in one kind, the use
In the delivery method of the drug for the treatment of scar include: hollow puncture needle include puncture cannula, needle core；Silicon capsule pipe is sent by needle core
In puncture cannula, puncture cannula is extracted, needle core heads on silicon capsule pipe and is placed in the position to be implanted into, also by needle core after needle guard is extracted
It extracts, completes the conveying of drug.
In conclusion advantages of the present invention and good effect are as follows:
What the present invention used dispel scorching relaxed and comfortable, diphenhydramine and Botulinum toxin type A are all clinical common drugs, and prolonged application does not have
There is side effect, the drug conveying for treating scar is implanted into scar by silicon capsule pipe by special trochar by the present invention, slowly
Drug is discharged, is taken out after scar levelling, effect is calmed down in the softening for reaching scar, is avoided and is frequently had an injection, costly also pain
Problem.
It is of the invention for treating the drug of scar by dispelling scorching relaxed and comfortable, diphenhydramine and Botulinum toxin type A forms, for treating
The device of scar is silicon capsule pipe, filled with the drug for treating scar in the silicon capsule pipe.Inflammation that the present invention used dispel
Relaxed and comfortable, diphenhydramine and Botulinum toxin type A are all clinical common drugs, are all that can clinically play by clinical prolonged application
The drug of good therapeutic effect, because drug dose very little, moreover it is inside scar, drug diffusion absorbs mainly in scar
Inside trace, systemic Absorption is seldom, small to systemic effects, will not generate side effect.
The device of drug for treating scar of the invention, described device are provided with silicon capsule pipe, the silicon capsule pipe
In filled with drug for treating scar.Other auxiliary tool is a hollow puncture needle, and there is cylindrical sleeve core in centre, is used for
Silicon capsule pipe equipped with drug conveys in scar, i.e. certain depth in casing piercing scar, after the length greater than silicon capsule pipe,
Silicon capsule pipe is sent into casing with needle core, needle core heads on silicon capsule pipe and reaches scheduled design position, after needle guard is extracted
Needle core is extracted, the transmission process of drug is completed.By newly being learnt in scar not yet to looking into for existing drug scar treatment
The technology for burying clay drug belongs to the pioneering of scar treatment.Clinical each 30 are injected in clay drug and scar by burying in scar
Comparative study buries clay other than the drug after local anaesthesia for the first time buries clay process and has pain in scar, remaining time does not have to again
It operates repeatedly, drug slow release sustained drug in scar plays a role, and the good expense of effect is low.Calm down the time and compares injecting method
20 days or so in advance.
Detailed description of the invention:
Fig. 1 is provided in an embodiment of the present invention for treating the apparatus structure schematic diagram of scar；
Fig. 2 is the structural schematic diagram of the casing bit of conveying drug provided in an embodiment of the present invention；
In figure: 1, silicon capsule pipe；2, puncture cannula；3, needle core.
Fig. 3 and Fig. 4 is provided in an embodiment of the present invention for treating the therapeutic effect schematic diagram of the drug of scar；
In figure: before (a) treating；(b) after treating.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
As shown in Figure 1, the device provided in an embodiment of the present invention for treating scar is provided with silicon capsule pipe 1, silicon capsule
Filled with the drug for treating scar in pipe 1.1 both ends of silicon capsule pipe are round blunt shape structure.
Drug provided in an embodiment of the present invention for treating scar is by hydrocortisone, diphenhydramine and Botulinum toxin type A
Composition.0.5% dispels scorching relaxed and comfortable 1 milliliter, and 1% 1 milliliter of diphenhydramine, 4 unit of Botulinum toxin type A mixing is infused for 3 milliliters totally as one
Penetrate unit.
If the hollow puncture needle of Fig. 2 includes puncture cannula 2, needle core 3；Silicon capsule pipe 1 is sent into puncture cannula 2 by needle core 3, is pulled out
Puncture cannula 2 out, needle core 3 head on silicon capsule pipe 1 and are placed in the position to be implanted into, and also extract needle core 3 after needle guard is extracted, and complete
The conveying of drug.It is the interior needle that intermediate hollow has cylinder, device for delivering a drug.Hollow puncture needle, among hollow needle
It with columned needle, is conveyed in the scar for silicon capsule pipe, i.e., casing is pierced into certain depth in scar, is greater than silicon capsule pipe
Length after, silicon capsule pipe is sent into casing with needle core, extracts puncture cannula, needle core heads on silicon capsule pipe and is placed in be implanted into
Needle core is also extracted after extracting needle guard in position, completes the transmission process of drug.
The present invention is by the way that the drug for being used to treat scar to be filled in silicon capsule pipe 1, with trochar 2 by silicon capsule pipe 1
It is implanted into scar, slow release drug, is taken out after scar levelling, effect is calmed down in the softening for reaching scar.
Technical effect of the invention is explained in detail with reference to the accompanying drawing.
As shown in Figure 3 and Figure 4, the present invention selects thicker scar to use in tertiary hospitals burn plastic and cosmetic center clinic
Scarring injector dispels and buries each 30 progress clinical comparison of clay in scorching relaxed and comfortable and scar, in terms of pain, treatment number of times, and the receiving of patient
Degree, several aspects such as speed that scar is calmed down are compared, and injection group all says that pain is heavier for 30 in scar, are treated every time all
Compare painful, mean treatment 8 ± 1.12 times, 30 unwilling to receive this treatment methods, and calming down the time is 60 ± 7.25 days.Scar
Clay patient is buried in trace and buries clay for the first time under anesthesia auxiliary also without pain, is treated 1 time, is preferred very much for 30 to receive this treatment side
Method, scar calm down the time 40 ± 5.18 days.
Drug provided in an embodiment of the present invention for treating scar is by scorching relaxed and comfortable, diphenhydramine and the Botulinum toxin type A group of dispelling
At proportion is: taking 0.5% to dispel scorching relaxed and comfortable 1 milliliter, 1% 1 milliliter of diphenhydramine, 4 unit of Botulinum toxin type A mixing is made for 3 milliliters totally
For an injection units, the size depending on scar carries out more or few injection units, and the device for treating scar is silicon capsule pipe,
Filled with the drug for treating scar in the silicon capsule pipe.What the present invention used dispel scorching relaxed and comfortable, diphenhydramine and A type meat poisoning
Element is all clinical common drug, is all the drug that can clinically play good therapeutic effect by clinical prolonged application, because
It for drug dose very little, moreover is inside scar, drug diffusion absorbs mainly inside scar, and systemic Absorption is seldom, right
Systemic effects are small, will not generate side effect.
Equipped with the device for treating the drug of scar, device is provided with silicon capsule pipe, the silica gel for offer of the invention
Filled with the drug for treating scar in capsule pipe.Other auxiliary tool is a hollow puncture needle, has circle among hollow needle
Column needle core conveys in the scar for silicon capsule pipe, i.e., casing is pierced into certain depth in scar, greater than the length of silicon capsule pipe
Afterwards, silicon capsule pipe is sent into casing with needle core, needle core heads on silicon capsule pipe and drug placement is pre-designed position, and pillowcase is extracted
Also needle core is extracted afterwards, completes the transmission process of drug.Silicon capsule pipe both ends are round blunt shape structure.Trochar be intermediate hollow simultaneously
With cylindrical type needle core.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (4)
1. a kind of for treating the drug of scar, which is characterized in that the drug for treating scar is dispelled scorching relaxed and comfortable, the extra large drawing of benzene
Bright and Botulinum toxin type A composition；0.5% dispels scorching relaxed and comfortable 1 milliliter, 1 milliliter of 1% diphenhydramine, 4 unit of Botulinum toxin type A, 3 milliliters of works totally
For an injection units.
2. drug as described in claim 1, which is characterized in that the drug is placed in silicon capsule pipe.
3. drug as claimed in claim 2, which is characterized in that silicon capsule pipe both ends are round blunt shape structure.
4. a kind of as described in claim 1 for treating the delivery method of the drug of scar, which is characterized in that described for controlling
It includes puncture cannula, needle core that the delivery method for treating the drug of scar, which includes: hollow puncture needle,；Silicon capsule pipe is sent into and is punctured by needle core
In casing, puncture cannula is extracted, and needle core heads on silicon capsule pipe and is placed in the position to be implanted into, also needle core pulled out after needle guard is extracted
Out, the conveying of drug is completed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910478332.3A CN110123819B (en) | 2019-06-03 | 2019-06-03 | Medicine and device for treating scars |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910478332.3A CN110123819B (en) | 2019-06-03 | 2019-06-03 | Medicine and device for treating scars |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110123819A true CN110123819A (en) | 2019-08-16 |
| CN110123819B CN110123819B (en) | 2022-03-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910478332.3A Active CN110123819B (en) | 2019-06-03 | 2019-06-03 | Medicine and device for treating scars |
Country Status (1)
| Country | Link |
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| CN (1) | CN110123819B (en) |
Citations (8)
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|---|---|---|---|---|
| CN1981865A (en) * | 2005-12-16 | 2007-06-20 | 冯时 | Formula and usage for treating acne |
| ES2310142A1 (en) * | 2007-06-15 | 2008-12-16 | Lipotec S.A | 6 -acyloxy- 7-meth0xy- 2, 2 -dimethylchromane compounds and their use as pigmentation-regulators |
| US20090214652A1 (en) * | 2003-11-20 | 2009-08-27 | Angiotech International Ag | Soft tissue implants and anti-scarring agents |
| CN102861318A (en) * | 2012-09-29 | 2013-01-09 | 山西医科大学 | Application of A-type kreotoxin heavy chains to exciting regeneration of neurite |
| CN103720681A (en) * | 2013-12-27 | 2014-04-16 | 柳州市工人医院 | Application of tranilast in preparing medicine for preventing pathological scar |
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-
2019
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090214652A1 (en) * | 2003-11-20 | 2009-08-27 | Angiotech International Ag | Soft tissue implants and anti-scarring agents |
| CN1981865A (en) * | 2005-12-16 | 2007-06-20 | 冯时 | Formula and usage for treating acne |
| ES2310142A1 (en) * | 2007-06-15 | 2008-12-16 | Lipotec S.A | 6 -acyloxy- 7-meth0xy- 2, 2 -dimethylchromane compounds and their use as pigmentation-regulators |
| CN102861318A (en) * | 2012-09-29 | 2013-01-09 | 山西医科大学 | Application of A-type kreotoxin heavy chains to exciting regeneration of neurite |
| CN103720681A (en) * | 2013-12-27 | 2014-04-16 | 柳州市工人医院 | Application of tranilast in preparing medicine for preventing pathological scar |
| CN105287441A (en) * | 2015-11-17 | 2016-02-03 | 哈尔滨乾佰纳生物药业有限公司 | Silica gel scar treatment strip and preparation method thereof |
| CN206434466U (en) * | 2016-10-21 | 2017-08-25 | 苏州灵岩医疗科技股份有限公司 | Safety-type subdermal implantation puts medicine pin |
| CN208741250U (en) * | 2017-07-12 | 2019-04-16 | 苏州灵岩医疗科技股份有限公司 | Crosspointer cast subdermal implantation sets medicine needle |
Non-Patent Citations (3)
| Title |
|---|
| MINGLEI BI ET AL: "Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis", 《MED SCI MONIT》 * |
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| Publication number | Publication date |
|---|---|
| CN110123819B (en) | 2022-03-15 |
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