CN110123777A - A kind of quickly disintegrated capsule shells based on polymalic acid - Google Patents
A kind of quickly disintegrated capsule shells based on polymalic acid Download PDFInfo
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- CN110123777A CN110123777A CN201910475245.2A CN201910475245A CN110123777A CN 110123777 A CN110123777 A CN 110123777A CN 201910475245 A CN201910475245 A CN 201910475245A CN 110123777 A CN110123777 A CN 110123777A
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- capsule shells
- capsule
- polymalic acid
- quickly disintegrated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Life Sciences & Earth Sciences (AREA)
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Abstract
The quickly disintegrated capsule shells based on polymalic acid that the invention discloses a kind of.The capsule shells include following component according to parts by weight: 18-25 parts of cementitious material, 1-7 parts of nano silver, blue extracting solution 10-18 parts of the flower in west, 0.02-0.08 parts of ginger essential oil, 15-28 parts of polymalic acid, 0.2-0.8 parts of melamine, 2-4 parts of castor oil, 15-20 parts of dendrobium polysaccharide, discarded 20-30 parts of lobster shell powder, 1-5 parts of Sodium Hyaluronate, 20-35 parts of water.The capsule shells component safety, it is low in cost, and disintegration rate is fast, application prospect is wide.
Description
Technical field
The invention belongs to capsule preparation technical fields, and in particular to a kind of quickly disintegrated capsule based on polymalic acid
Shell.
Background technique
Disintegration refers to the physical dissolution process of pharmaceutical preparation before it is absorbed.Disintegration time refers under certain condition, ball, piece,
Capsule is disintegrated the time for becoming particle, and Zeng Yidu is considered as the principal element for influencing oral drug bioavailability,
It recognizes, be disintegrated, the especially disintegration of slightly water-soluble preparation is not meant to absorb.Hard capsule should be in 30min in capsule
Interior all disintegration, soft capsule should be all disintegrated in 1h.Disintegration refers to some drugs dosage form (tablet, pill etc.), uses
The detection device of States Pharmacopoeia specifications, the whole measured under certain condition are disintegrated and by the limits the time required to sieve.It is used to collapse
Solving medium is usually water, simulated intestinal fluid, simulated gastric fluid.Measuring temperature is to 37 ± 0.5 DEG C.Be measure drug quality index it
One.
Polymalic acid (PMLA) is a kind of biodegradable water-soluble aliphatic polyester, and pendant carboxy group can lead to
It crosses and connects a variety of groups and be modified, be finally degraded to water and carbon dioxide, no cumulative toxicity, in life under the action of enzyme in vivo
Opposite highly dissoluble, high spontaneous degradation rate and immunologic inertia under the conditions of reason make it become new better than polysaccharide and polypeptide
Type boiomacromolecule.
For capsule as pharmaceutical dosage form common in modern medical service, the absorption dress that disintegration rate directly influences drug is fast,
How to prepare one kind can quickly disintegrated hard capsule case or soft capsule shell, be the project for being worth everybody to probe into.
Summary of the invention
In view of the above technical problems, the present invention provides a kind of quickly disintegrated capsule shells based on polymalic acid, the capsule
Shell component safety, it is low in cost, and disintegration rate is fast, application prospect is wide.
A kind of quickly disintegrated capsule shells based on polymalic acid, including following component according to parts by weight: gelling material
18-25 parts of material, 1-7 parts of nano silver, west blue flower extracting solution 10-18 parts, 0.02-0.08 parts of ginger essential oil, polymalic acid 15-28
Part, 0.2-0.8 parts of melamine, 2-4 parts of castor oil, 15-20 parts of dendrobium polysaccharide, discarded 20-30 parts of lobster shell powder, hyaluronic acid
1-5 parts of sodium, 20-35 parts of water.
The above-mentioned quickly disintegrated capsule shells based on polymalic acid as improved, including it is following according to parts by weight
Component: 20 parts of cementitious material, 5 parts of nano silver, blue flower 15 parts of the extracting solution, 0.05 part of ginger essential oil, 24 parts of polymalic acid, three in west
0.5 part of poly cyanamid, 3 parts of castor oil, 18 parts of dendrobium polysaccharide, discarded 25 parts of lobster shell powder, 4 parts of Sodium Hyaluronate, 28 parts of water.
It is that the capsule shells are hard capsule case as improved.
It is that the capsule shells include capsule body and capsule cap as improved, the capsule body is equipped with pre- lock ring, institute
The capsule cap stated is equipped with whole lock ring.
It is that the gel rubber material is gelatin, pulullan polysaccharide or carragheen as improved.
It is the preparation method of the discarded lobster shell powder as improved, after discarded lobster shell is cleaned up, puts into ball
It is ground in grinding machine, it is spare after pasteurization.
The utility model has the advantages that
Compared with prior art, a kind of quickly disintegrated capsule shells based on polymalic acid of the present invention, the capsule shells are with poly- apple
Acid is cosolvent, and the capsule shells for cooperating nano silver and dendrobium polysaccharide to be prepared, disintegration rate is fast, ingredient safety, using discarded
Lobster shell substitution it is calcareous, dendrobium polysaccharide substitutes polysaccharide and reducing agent, and ginger essential oil substitutes lubricant, after being disintegrated in human body
Human immunological competence is improved indirectly, and has widened calcareous source for human body.
Specific embodiment
The invention will be further described combined with specific embodiments below.
Embodiment 1
A kind of quickly disintegrated capsule shells based on polymalic acid, including following component according to parts by weight: 18 parts of gelatin is received
1 part of rice silver, blue 10 parts of the extracting solution of flower in west, 0.02 part of ginger essential oil, 15 parts of polymalic acid, 0.2 part of melamine, 2 parts of castor oil,
15 parts of dendrobium polysaccharide, discarded 20 parts of lobster shell powder, 1 part of Sodium Hyaluronate, 20 parts of water.
The capsule shells are hard capsule case.
The capsule shells include capsule body and capsule cap, and the capsule body is equipped with pre- lock ring, on the capsule cap
Equipped with whole lock ring.
The preparation method of the discarded lobster shell powder after cleaning up discarded lobster shell, puts into ball mill and grinds, bar
It is spare after family name's disinfection.
The preparation method of above-mentioned capsule shells, referring to the technology of preparing of any capsule shells in the prior art, there is no any
Particularity.
According to providing in pharmacopeia, the disintegration time of the capsule shells is 6-8 minutes.And the capsule shells of different addition polymalic acids
As a comparison case, disintegration rate is 9-10 minutes.
Embodiment 2
A kind of quickly disintegrated capsule shells based on polymalic acid, including following component according to parts by weight: Propiram more 20
Part, 5 parts of nano silver, blue flower 15 parts of the extracting solution, 0.05 part of ginger essential oil, 24 parts of polymalic acid, 0.5 part of melamine, castor-oil plant in west
3 parts of oil, 18 parts of dendrobium polysaccharide, discarded 25 parts of lobster shell powder, 4 parts of Sodium Hyaluronate, 28 parts of water.
The capsule shells are hard capsule case.
The capsule shells include capsule body and capsule cap, and the capsule body is equipped with pre- lock ring, on the capsule cap
Equipped with whole lock ring.
The preparation method of the discarded lobster shell powder after cleaning up discarded lobster shell, puts into ball mill and grinds, bar
It is spare after family name's disinfection.
The preparation method of above-mentioned capsule shells, referring to the technology of preparing of any capsule shells in the prior art, there is no any
Particularity.
According to providing in pharmacopeia, the disintegration time of the capsule shells is 6-8 minutes.And the capsule shells of different addition polymalic acids
As a comparison case, disintegration rate is 15-20 minutes.
Embodiment 3
A kind of quickly disintegrated capsule shells based on polymalic acid, including following component according to parts by weight: carragheen 18-25
Part, 1-7 parts of nano silver, west blue flower extracting solution 10-18 parts, 0.02-0.08 parts of ginger essential oil, 15-28 parts of polymalic acid, melamine
0.2-0.8 parts of amine, 2-4 parts of castor oil, 15-20 parts of dendrobium polysaccharide, discarded 20-30 parts of lobster shell powder, 1-5 parts of Sodium Hyaluronate,
20-35 parts of water.
The capsule shells are hard capsule case.
The capsule shells include capsule body and capsule cap, and the capsule body is equipped with pre- lock ring, on the capsule cap
Equipped with whole lock ring.
The preparation method of the discarded lobster shell powder after cleaning up discarded lobster shell, puts into ball mill and grinds, bar
It is spare after family name's disinfection.
The preparation method of above-mentioned capsule shells, referring to the technology of preparing of any capsule shells in the prior art, there is no any
Particularity.
According to providing in pharmacopeia, the disintegration time of the capsule shells is 6-8 minutes.
Comparative example 1
In addition to without containing nano silver, remaining is the same as embodiment 1.
The preparation method of above-mentioned capsule shells, referring to the technology of preparing of any capsule shells in the prior art, there is no any
Particularity.
According to providing in pharmacopeia, the disintegration time of the capsule shells is 6-8 minutes.Fungistatic effect is deteriorated.
The foregoing is only a preferred embodiment of the present invention, the scope of protection of the present invention is not limited to this, it is any ripe
Know those skilled in the art within the technical scope of the present disclosure, the letter for the technical solution that can be become apparent to
Altered or equivalence replacement are fallen within the protection scope of the present invention.
Claims (6)
1. a kind of quickly disintegrated capsule shells based on polymalic acid, which is characterized in that including following group according to parts by weight
Point: 18-25 parts of cementitious material, 1-7 parts of nano silver, west blue flower extracting solution 10-18 parts, 0.02-0.08 parts of ginger essential oil, poly- apple
15-28 parts sour, 0.2-0.8 parts of melamine, 2-4 parts of castor oil, 15-20 parts of dendrobium polysaccharide, discarded 20-30 parts of lobster shell powder,
1-5 parts of Sodium Hyaluronate, 20-35 parts of water.
2. the quickly disintegrated capsule shells of polymalic acid according to claim 1, which is characterized in that including it is following by weight
The component of number meter: 20 parts of cementitious material, 5 parts of nano silver, blue flower 15 parts of the extracting solution, 0.05 part of ginger essential oil, polymalic acid in west
24 parts, 0.5 part of melamine, 3 parts of castor oil, 18 parts of dendrobium polysaccharide, discarded 25 parts of lobster shell powder, 4 parts of Sodium Hyaluronate, water 28
Part.
3. the quickly disintegrated capsule shells of polymalic acid according to claim 1, which is characterized in that the capsule shells are hard
Capsule shells.
4. the quickly disintegrated capsule shells of polymalic acid according to claim 1, which is characterized in that the capsule shells include
Capsule body and capsule cap, the capsule body are equipped with pre- lock ring, and the capsule cap is equipped with whole lock ring.
5. the quickly disintegrated capsule shells of polymalic acid according to claim 1, which is characterized in that the gel rubber material is
Gelatin, pulullan polysaccharide or carragheen.
6. the quickly disintegrated capsule shells of polymalic acid according to claim 1, which is characterized in that the discarded lobster shell
The preparation method of powder after cleaning up discarded lobster shell, puts into ball mill and grinds, spare after pasteurization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910475245.2A CN110123777A (en) | 2019-06-03 | 2019-06-03 | A kind of quickly disintegrated capsule shells based on polymalic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910475245.2A CN110123777A (en) | 2019-06-03 | 2019-06-03 | A kind of quickly disintegrated capsule shells based on polymalic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110123777A true CN110123777A (en) | 2019-08-16 |
Family
ID=67579880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910475245.2A Pending CN110123777A (en) | 2019-06-03 | 2019-06-03 | A kind of quickly disintegrated capsule shells based on polymalic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110123777A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101069677A (en) * | 2007-06-15 | 2007-11-14 | 潮州市强基制药厂 | Pullulan polysaccharide hollow hard capasule and its preparing method |
| CN103315975A (en) * | 2013-06-05 | 2013-09-25 | 天津科技大学 | Gelatin-CaCO3 mineral capsule shell and preparation method thereof |
| US20170304374A1 (en) * | 2014-10-23 | 2017-10-26 | Symbiotic Health Inc. | Capsule for the oral administration of biopharmaceuticals |
-
2019
- 2019-06-03 CN CN201910475245.2A patent/CN110123777A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101069677A (en) * | 2007-06-15 | 2007-11-14 | 潮州市强基制药厂 | Pullulan polysaccharide hollow hard capasule and its preparing method |
| CN103315975A (en) * | 2013-06-05 | 2013-09-25 | 天津科技大学 | Gelatin-CaCO3 mineral capsule shell and preparation method thereof |
| US20170304374A1 (en) * | 2014-10-23 | 2017-10-26 | Symbiotic Health Inc. | Capsule for the oral administration of biopharmaceuticals |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190816 |
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| RJ01 | Rejection of invention patent application after publication |