CN110123308A - The detection method of noninvasive Fetal ECG signal R wave - Google Patents
The detection method of noninvasive Fetal ECG signal R wave Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
- A61B5/344—Foetal cardiography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
- A61B5/346—Analysis of electrocardiograms
- A61B5/349—Detecting specific parameters of the electrocardiograph cycle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/725—Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/02—Foetus
Abstract
The detection method of noninvasive Fetal ECG signal R wave, belongs to pregnant woman's Fetal ECG detection technique field.The present invention provides the detection methods that one kind can accurately detect high, strong antijamming capability the noninvasive Fetal ECG signal R wave of Fetal ECG signal, accuracy.In the present invention, her abdominal original signal is pre-processed, the power frequency interference signals of power supply are filtered;Obtain pregnant woman's electrocardiosignal QRS wave group;Between two QRS complexes of pregnant woman, the R wave of Fetal ECG signal is detected;From the R wave of the Fetal ECG signal detected, the regional location for the Fetal ECG signal R wave being overlapped with pregnant woman's electrocardiosignal QRS wave group is predicted;Establish Fetal ECG signal QRS complex template and pregnant woman's electrocardiosignal QRS wave group template;Regional location fusion is being predicted, is calculating related coefficient, related coefficient is maximum, as the accurate location of Fetal ECG signal R wave.Present invention is mainly used for detection Fetal ECG signal R waves.
Description
Technical field
The invention belongs to pregnant woman's Fetal ECG detection technique fields, and in particular to the detection of noninvasive Fetal ECG signal R wave
Method.
Background technique
Fetal ECG signal can be very good the health status of diagnosing fetal, for example, the heart rate of fetus, heart rate variability with
Fetal anoxia state correlation etc..Since fetus is in pregnant woman's body, directly acquiring Fetal ECG signal is invasive method, is existed very
More uncertain danger.Currently, it extracts Fetal ECG signal and mainly passes through the noninvasive indirect gain of her abdominal electrode, method is not only
It is simple and effective, more importantly safe, so noninvasive Fetal ECG signal detection is considered as a up-and-coming method.So
And this abdomen signal extracted not only includes fetal signals, there are also pregnant woman's electrocardiosignal, pregnant woman's breath signal, movement are pseudo-
Mark etc., these interference signal intensities are big, and pregnant woman's electrocardiosignal and Fetal ECG signal are overlapped in time-domain and frequency-domain, pass
The digital filtering method of system cannot isolate Fetal ECG signal.So accurately extracting noninvasive Fetal ECG signal is considered as one
A challenging work.
Traditional electrocardiosignal R detection method can be extracted and the unfolded fetus heart of pregnant woman's electrocardiosignal QRS wave group
R wave in electric signal;It need to mainly be to solve how to extract and believe with the overlapped Fetal ECG of pregnant woman electrocardiosignal QRS complex group
R wave in number;Because of QRS complex intensity with higher in pregnant woman's electrocardiosignal, Fetal ECG signal R wave is often flooded.
It can accurately detect that Fetal ECG signal, accuracy be high, noninvasive tire of strong antijamming capability it is therefore desirable to a kind of
The detection method of youngster's R wave of electrocardiosignal.
Summary of the invention
Cannot accurately to detect Fetal ECG signal, precision low, anti-for existing Fetal ECG detection method by the present invention
The strong defect of interference performance, providing a kind of can accurately detect that Fetal ECG signal, accuracy be high, nothing of strong antijamming capability
Create the detection method of Fetal ECG signal R wave.
The technical solution of the detection method of noninvasive Fetal ECG signal R wave according to the present invention is as follows:
The detection method of noninvasive Fetal ECG signal R wave according to the present invention, it the following steps are included:
Step 1: pre-processing to her abdominal original signal, digital band pass is carried out to the power frequency interference signals of power supply
Filtering;
Step 2: the R wave of electrocardiosignal of detection pregnant woman, to obtain pregnant woman's electrocardiosignal QRS wave group;
Step 3: detecting the R wave of Fetal ECG signal between two QRS complexes of pregnant woman;
Step 4: according to characteristic paracycle of electrocardiosignal, from the R wave of the Fetal ECG signal detected, prediction with it is pregnant
The regional location for the Fetal ECG signal R wave that woman's electrocardiosignal QRS wave group is overlapped;
Step 5: establishing a tire using singular value decomposition method according to 6 adjacent Fetal ECG signal QRS complexes
Youngster's electrocardiosignal QRS wave group template;According to 6 it is adjacent pregnant woman's electrocardiosignal QRS wave group is not overlapped with fetal signals, use surprise
Different value decomposition method establishes pregnant woman's electrocardiosignal QRS wave group template;
Step 6: being predicted according to Fetal ECG signal QRS complex template and pregnant woman's electrocardiosignal QRS wave group template
Regional location fusion, fused signal and actual signal calculate related coefficient, maximum related coefficient, as fetus
The accurate location of R wave of electrocardiosignal.
Further: in step 5, the singular value decomposition method specifically: adjacent according to 6 had been detected by
Pregnant woman's electrocardiosignal is not overlapped with fetal signals, we can establish following matrix,
Wherein each row represents one and has detected pregnant woman's electrocardiosignal, and X matrix is 6 rows, i.e. p=6 believes according to pregnant woman's electrocardio
Number the characteristics of, pregnant woman's electrocardiosignal length is set as 0.16s by we, if being sampled as 1khz, i.e. q=160.Wherein all letters
The alignment of number R wave train, position is in the centre of signal.
X matrix can be expressed as decomposing:
X=USVT
Wherein, U is m × m rank unitary matrice;S is positive semidefinite m × n rank diagonal matrix;V is n × n rank unitary matrice.Such point
Solution is referred to as the singular value decomposition of X.Element on S diagonal line is the singular value of X.
Further: in step 5, the QRS complex template of the Fetal ECG signal are as follows:
M=[tmQRS]q
The QRS complex template of the electrocardiosignal are as follows:
fi=[0 tfQRS 0]q
Wherein, tmQRSThe template of pregnant woman's electrocardiosignal QRS wave group, q represent the length of sampled signal;tfQRSFetal ECG
The template of signal QRS complex, q represent the length of sampled signal.
Further: in step 6, according to the region 10%refRR is obtained, carries out, define related coefficient calculation formula:
Represent MiVector, tcRepresent true signal;
Wherein, riIt is related coefficient,WithIt is vectorAnd tcMean value;
Determine the following formula in position: I=armaxri, that is, obtaining related coefficient, by comparing, the maximum phase of acquisition
Relationship number is the position of determining Fetal ECG signal.
The beneficial effect of the detection method of noninvasive Fetal ECG signal R wave according to the present invention is:
The detection method of noninvasive Fetal ECG signal R wave according to the present invention, accuracy with higher.This method makes
Elimination method is replaced with template matching method, for the part of non-pregnant woman's QRS complex, uses traditional R wave detecting method, Ke Yiti
Take Fetal ECG signal R wave;Since R wave has the characteristics that quasi-periodic, according to this feature, can predict and pregnant woman's QRS complex
Equitant fetus R wave regional location;Then pregnant woman and Fetal ECG the signal QRS complex template to establish is used to blend,
It is matched with actual QRS complex;Two Waveform Correlations are most strong, as Fetal ECG signal R wave position.It can detecte out in this way
All R wave positions.
Detailed description of the invention
Fig. 1 is the flow diagram of the detection method of noninvasive Fetal ECG signal R wave;
Fig. 2 is the curve graph of the phase and amplitude distortion of the R wave of Fetal ECG signal;
Fig. 3 is the curve graph of RR sequence lubrication.
Specific embodiment
Below with reference to embodiment, the following further describes the technical solution of the present invention, and however, it is not limited to this, all right
Technical solution of the present invention is modified or replaced equivalently, and without departing from the spirit and scope of the technical solution of the present invention, should all be contained
Lid is within the protection scope of the present invention.
Embodiment 1
Illustrate the present embodiment in conjunction with Fig. 1-Fig. 3, in the present embodiment, noninvasive Fetal ECG signal involved in the present embodiment
The detection method of R wave, it the following steps are included:
Step 1: pre-processed to her abdominal original signal, including bandpass filtering (filter range be [10hz,
100hz]), the power frequency interference signals of power supply are filtered;
Step 2: the R wave of electrocardiosignal of detection pregnant woman, to obtain pregnant woman's electrocardiosignal QRS wave group;
Step 3: detecting the R wave of Fetal ECG signal between two QRS complexes of pregnant woman;
Step 4:, from the R wave of the Fetal ECG signal of detection, can be predicted according to characteristic paracycle of electrocardiosignal
The regional location for the Fetal ECG signal R wave being overlapped out with pregnant woman's electrocardiosignal QRS wave group;
Step 5: establishing a tire using singular value decomposition method according to 6 adjacent Fetal ECG signal QRS complexes
Youngster's electrocardiosignal QRS wave group template;According to 6 it is adjacent pregnant woman's electrocardiosignal QRS wave group is not overlapped with fetal signals, use surprise
Different value decomposition method establishes pregnant woman's electrocardiosignal QRS wave group template;
Step 6: being predicted according to this Fetal ECG signal QRS complex template and pregnant woman's electrocardiosignal QRS wave group template
Regional location merges out, and the signal of fusion calculates correlation with actual signal, and related coefficient is maximum, as fetus
The accurate location of R wave of electrocardiosignal.
The detection method of noninvasive Fetal ECG signal R wave, mainly using template matching method strengthen accurate positioning with it is pregnant
The R wave of the duplicate Fetal ECG signal of woman's electrocardiosignal QRS wave group, so as to the RR and the heart of accurate movable Fetal ECG signal
Rate.The singular value decomposition method specifically:
For establishing pregnant woman's electrocardiosignal template, adjacent it is not overlapped with fetal signals according to 6 had been detected by
Pregnant woman's electrocardiosignal establishes following matrix,
Wherein, every row represents one and has detected pregnant woman's electrocardiosignal, and X matrix is 6 rows, i.e. p=6 believes according to pregnant woman's electrocardio
Number, pregnant woman's electrocardiosignal length is set as 0.16s, if being sampled as 1khz, i.e. q=160, q represent the length of sampled signal
Degree.Wherein all R wave of electrocardiosignal column alignments, position is in the centre of signal.
X matrix can be expressed as decomposing:
X=USVT
Wherein, U is m × m rank unitary matrice;S is positive semidefinite m × n rank diagonal matrix;V is n × n rank unitary matrice.Such point
Solution is referred to as the singular value decomposition of X.Element on S diagonal line is the singular value of X.
Corresponding first feature vector of first column of U, represents maximum energy.Rule of thumb, the first row of U, S are taken
First diagonal element, V takes the first row, regained a signal, the pregnant woman's electrocardiosignal template as established;It is denoted as
M=[tmQRS]q, the electrocardiosignal for similarly establishing a fetus is denoted as fi=[0 tfQRS 0]q, wherein establishing Fetal ECG signal
When X matrix, the signal length time is 40, if using the time for 1Khz, q=40.By the method for singular value decomposition, I
Establish the templates of pregnant woman and fetal signals, be denoted as respectively:
M=[tmQRS]q, fi=[0 tfQRS 0]q;
Wherein, tmQRSThe template of pregnant woman's electrocardiosignal QRS wave group, q represent the length of sampled signal;tfQRSFetal ECG
The template of signal QRS complex, q represent the length of sampled signal.
As shown in Fig. 2, traditional method mainly uses template elimination method.The method detects pregnant woman's electrocardiosignal R first
Then wave establishes pregnant woman's electrocardiosignal template, and eliminates pregnant woman's electrocardiosignal using abdomen signal, to only obtain Fetal ECG
Signal detects fetus R wave signal finally using traditional R wave of electrocardiosignal detection method.The shortcomings that the method be to pregnant woman's heart
The fetal signals R wave of electric signal QRS complex overlapping can have the phase of Fetal ECG signal R wave when eliminating using template
Position and amplitude distortion, so that there are errors on calculating Fetal ECG signal RR, heart rate.This method advantage is and other method ratios
Compared with accuracy with higher.
As shown in figure 3, according to two Fetal ECG signals on inspection, such as point red in figure, it is estimated that whether
In the presence of the Fetal ECG signal being overlapped with pregnant woman's Fetal ECG signal not detected, from the figure, it can be seen that according to fetus
Electrocardiosignal characteristic paracycle, there are a Fetal ECG signals.But accurately position is unable to estimate out, because pregnant
Woman's electrocardiosignal floods, this when is merged according to two foundation.Position first among two Fetal ECG signals
(i.e. blue+number) the left and right region 5%refRR (total 10%refRR), it is positioned as predicting Fetal ECG signal area.According to amount
Two templates established carry out addition fusion, are denoted as Mi=m+fi, wherein m=[tmQRS]q, fi=[0 tfQRS 0]q, i be exist
10%refRR sliding.
According to the region 10%refRR are obtained, correlation calculations are carried out, define following formula first:
Represent MiVector, tcRepresent true signal;
Wherein, riIt is related coefficient,WithIt is vectorAnd tcMean value;
Determine the following formula in position: I=argmaxri, that is, a series of related coefficients are being obtained, by comparing, acquisition is most
Big related coefficient, as we it needs to be determined that Fetal ECG signal position.
This method replaces elimination method using template matching method;For the part of non-pregnant woman's QRS complex, traditional R is used
Wave detecting method can extract Fetal ECG signal R wave;Due to R wave have the characteristics that it is quasi-periodic, can be pre- according to this feature
It measures and the equitant fetus R wave regional location of pregnant woman's QRS complex;Then the pregnant woman to establish and Fetal ECG signal are used
QRS complex template blends, and matches with actual QRS complex;Two Waveform Correlations are most strong, as Fetal ECG signal R wave
Position;It can detecte out all R wave positions.
Claims (4)
1. the detection method of noninvasive Fetal ECG signal R wave, which is characterized in that it the following steps are included:
Step 1: pre-processing to her abdominal original signal, digital band pass filtering is carried out to the power frequency interference signals of power supply;
Step 2: the R wave of electrocardiosignal of detection pregnant woman, to obtain pregnant woman's electrocardiosignal QRS wave group;
Step 3: detecting the R wave of Fetal ECG signal between two QRS complexes of pregnant woman;
Step 4: according to characteristic paracycle of electrocardiosignal, from the R wave of the Fetal ECG signal detected, prediction and pregnant woman's heart
The regional location for the Fetal ECG signal R wave that electric signal QRS complex is overlapped;
Step 5: establishing a fetus heart using singular value decomposition method according to 6 adjacent Fetal ECG signal QRS complexes
Electric signal QRS complex template;According to 6 it is adjacent pregnant woman's electrocardiosignal QRS wave group is not overlapped with fetal signals, use singular value
Decomposition method establishes pregnant woman's electrocardiosignal QRS wave group template;
Step 6: predicting region according to Fetal ECG signal QRS complex template and pregnant woman's electrocardiosignal QRS wave group template
Co-factor propagation, fused signal and actual signal calculate related coefficient, maximum related coefficient, as Fetal ECG
The accurate location of signal R wave.
2. the detection method of noninvasive Fetal ECG signal R wave according to claim 1, which is characterized in that in step 1,
In step 5, the singular value decomposition method specifically: adjacent be not overlapped with fetal signals according to 6 had been detected by
Pregnant woman's electrocardiosignal, we can establish following matrix,
Wherein each row represents one and has detected pregnant woman's electrocardiosignal, and X matrix is 6 rows, i.e. p=6, according to pregnant woman's electrocardiosignal
Feature, pregnant woman's electrocardiosignal length is set as 0.16s by we, if being sampled as 1khz, i.e. q=160.Wherein all signal R
Wave train alignment, position is in the centre of signal.
X matrix can be expressed as decomposing:
X=USVT
Wherein, U is m × m rank unitary matrice;S is positive semidefinite m × n rank diagonal matrix;V is n × n rank unitary matrice.Such decomposition is just
The referred to as singular value decomposition of X.Element on S diagonal line is the singular value of X.
3. the detection method of noninvasive Fetal ECG signal R wave according to claim 1, which is characterized in that in step 1,
In step 5, the QRS complex template of the Fetal ECG signal are as follows:
M=[tmQRS]q
The QRS complex template of the electrocardiosignal are as follows:
fi=[0 tfQRS 0]q
Wherein, tmQRSThe template of pregnant woman's electrocardiosignal QRS wave group, q represent the length of sampled signal;tfQRSFetal ECG signal
The template of QRS complex, q represent the length of sampled signal.
4. the detection method of noninvasive Fetal ECG signal R wave according to claim 1, which is characterized in that in step 1,
In step 6, according to the region 10%refRR is obtained, carries out, defines related coefficient calculation formula:
Represent MiVector, tcRepresent true signal;
Wherein, riIt is related coefficient,WithIt is vectorAnd tcMean value;
Determine the following formula in position: I=argmaxri, that is, obtaining related coefficient, by comparing, the maximum phase relation of acquisition
Number, is the position of determining Fetal ECG signal.
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