CN110101748A - A kind of sublingual Thrombolytic agent and preparation method thereof - Google Patents
A kind of sublingual Thrombolytic agent and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of sublingual Thrombolytic agents and preparation method thereof, its traditional Chinese medicinal material raw materials includes 3-8 parts of Radix Astragali, 5-8 parts of the root of Dahurain angelica, 5-10 parts of olibanum, 5-10 parts of myrrh, 5-10 parts of the rhizome of davallia, 5-8 parts of cloves, 3-8 parts of cortex cinnamomi, 5-10 parts of Rhizoma Chuanxiong, 10-25 parts of safflower, 15-30 parts of radix achyranthis bidentatae, 15-20 parts of Radix Salviae Miltiorrhizae, 8-15 parts of ginseng.Sublingual Thrombolytic agent of the present invention and preparation method thereof, preparation method is simple, and the Chinese materia medica preparation in formula has the function of apparent activating microcirculation and removing stasis medicinal, thrombus, and the occurrence probability of hypertension, hyperlipidemia, hyperglycemia can be effectively reduced.
Description
Technical field
The invention belongs to Chinese medicine preparation technical fields, and in particular to a kind of sublingual Thrombolytic agent and preparation method thereof.
Background technique
Thrombus is made of insoluble fibrin, the blood platelet of deposition, the leucocyte of accumulation and the red blood cell that falls into, blood
Thrombus in pipe deposits in human body, easily causes numerous diseases, therefore thrombus is the formidable enemy for influencing human health, it is easy to cause
Life danger.And hypertension, hyperlipidemia, hyperglycemia may all cause thrombus.The body 98% of people has mobility, only
Head head does not have, and is all easy to concentrate on head so hemostasis, thrombus, blood are sticky, and the place of head storage blood rubbish is in tongue
At lower saliva gold and good wine two, if siltation will excessively cause various diseases, therefore the disease on prevention cardiovascular and cerebrovascular is wanted just
Thrombus at blood vessel need to be removed.
The existing method for dispelling thrombus has using bloodletting threapy, by special cutter (mostly three-edged needle) in sublingual Jinin
Bloodletting is punctured at good wine, and siltation thrombus herein is removed.But such treatment method needs are punctured sublingual, and patient is wanted
Bear biggish pressure at heart.
Summary of the invention
To solve the above problems, the present invention devises a kind of sublingual Thrombolytic agent and preparation method thereof, preparation method is simple,
Chinese materia medica preparation has the function of apparent activating microcirculation and removing stasis medicinal, thrombus, and hypertension, hyperlipidemia, hyperglycemia can be effectively reduced
Occurrence probability.
To achieve the above object, the invention adopts the following technical scheme: a kind of sublingual Thrombolytic agent, including following weight
Part raw material: 3-8 parts of Radix Astragali, 5-8 parts of the root of Dahurain angelica, 5-10 parts of olibanum, 5-10 parts of myrrh, 5-10 parts of the rhizome of davallia, 5-8 parts of cloves, cortex cinnamomi
3-8 parts, 5-10 parts of Rhizoma Chuanxiong, 10-25 parts of safflower, 15-30 parts of radix achyranthis bidentatae, 15-20 parts of Radix Salviae Miltiorrhizae, 8-15 parts of ginseng.
As a kind of further improvement of sublingual Thrombolytic agent of the present invention: further including following raw materials in part by weight: lanatechead saussurea herb with flower 3-5
Part, 10-15 parts of leech, 3-5 parts of cordyceps sinensis.
As a kind of further improvement of sublingual Thrombolytic agent of the present invention: including column raw material: 3 parts of Radix Astragali, the root of Dahurain angelica 5
Part, 5 parts of olibanum, 5 parts of myrrh, 5 parts of the rhizome of davallia, 5 parts of cloves, 3 parts of cortex cinnamomi, 5 parts of Rhizoma Chuanxiong, 10 parts of safflower, 15 parts of radix achyranthis bidentatae, Radix Salviae Miltiorrhizae 15
Part, 8 parts of ginseng, 3 parts of lanatechead saussurea herb with flower, 10 parts of leech, 3 parts of cordyceps sinensis.
As a kind of further improvement of sublingual Thrombolytic agent of the present invention: the raw material is formed using organic solvent is brewed.
As a kind of further improvement of sublingual Thrombolytic agent of the present invention: the weight ratio of above-mentioned raw materials and organic solvent is 1:
(10-20), the organic solvent are 65 ° of -75 ° of brewing grains white spirits.
To achieve the above object, the invention adopts the following technical scheme: a kind of preparation of such as above-mentioned sublingual Thrombolytic agent
Method includes the following steps:
1) cleaning and crushing, by Radix Astragali, the root of Dahurain angelica, the rhizome of davallia, cloves, cortex cinnamomi, Rhizoma Chuanxiong, safflower, radix achyranthis bidentatae, Radix Salviae Miltiorrhizae, ginseng, saussurea involucrata
Flower, respectively impurity elimination, clean, dry and be crushed to powder or 0.5-1cm square；By olibanum, do not have medicinal vinegar after crush；By leech,
Cordyceps sinensis crushes after air-drying；
2) brewed, raw material is placed at least one brewed moon in brewing grains white spirit, filters to obtain primary liquor and brewed rear raw material；
3) it rolls, brewed rear raw material is rolled by juice press and is taken, filtering and removing slag obtain second level liquor；
4) it mixes, primary liquor and second level liquor is mixed, packing.
Radix Astragali: it is warm-natured sweet in flavor, there is the effects of tonifying speen and tonifying kidney, heart tonifying clearing lung-heat, dispersing stagnated hepatoqi, blood pressure lowering, it is chronic to improving
Ephritis, hypertension, diabetes have good curative effect.
The root of Dahurain angelica: warm-natured, acrid flavour, gas fragrance, slight bitter.With wind-damp dispelling, promoting blood circulation row is become silted up, moreover it is possible to improve local blood circulation,
Pigment excess accumulation in the tissue is eliminated, skin cell metabolism is promoted.
Olibanum: blood-activating and qi-promoting, inducing meastruation to relieve menalgia, detumescence and promoting granulation control qi and blood stagnation, bruise stasis caused pain, control swollen ulcer drug, acute appendicitis,
Unhealing ulcer, ruptured abscess resistant to healing.
Myrrh: chest and abdomen stasis caused pain, dysmenorrhea, menostasis, abdominal mass, traumatic injury, carbuncle swells sore, acute appendicitis, red eye, swell pain are controlled.Myrrh pair
Treat wound, dermatitis effect it is fine, to bronchitis, cough, bacterium infection and the infection of Hui bacterium are helpful.There is promoting blood circulation to stop
Bitterly, detumescence and promoting granulation and other effects is the Chinese medicine of a kind of promoting blood circulation, stagnation resolvation, analgesic, stomach invigorating；
The rhizome of davallia: it is bitter, warm-natured, there is promoting blood circulation, hemostasia effect；
Cloves: inhibit platelet aggregation, have the function of anticoagulation, antithrombotic；
Cortex cinnamomi: the formation of vein or arterial thrombus can be prevented；
Rhizoma Chuanxiong: acrid flavour micro-sweet, temperature, promote breath and open depression, it is wet to dispel wind-dryness, promoting blood circulation and stopping pain；
Safflower: blood circulation, removing blood stasis and acesodyne have the effect of activating microcirculation and removing stasis medicinal, dissipate wet effect going to swell；
Radix achyranthis bidentatae: bitter；Acid；It is mild-natured, enter liver；Kidney channel, main promoting blood circulation；
Radix Salviae Miltiorrhizae: promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle；
Ginseng: sweet in flavor, slight bitter, it is warm-natured, flat, expand vascular study platelet aggregation；
Lanatechead saussurea herb with flower: warm-natured, blood-enrich, clearing heat and detoxicating, detumescence, analgesic；
Leech: taste is salty, bitter, mild-natured；Return liver warp has dissipating blood stasis with potent drugs, the function of promoting menstruation；
Cordyceps sinensis: it has the function of adjusting immune system, hemostasis containing cordycepin.
Myrrh, olibanum and Radix Salviae Miltiorrhizae compatibility can control internal injury hemostasis, trusted subordinate's pain, the diseases such as limb arm pain.
Myrrh, olibanum and safflower compatibility can control blood stasis and swelling pain, hemostasis costalgia, carbuncle swells and haematemesis and have the stagnant person of the stasis of blood.
Rhizoma Chuanxiong, which includes 1 ℅ alkaloids of volatile oil, ligustrazine L- isoleucyl--Valine liver L-(5- methylol -2-
Furyl)-B- card quinoline isolates 18 lactone constituents, phenols and organic acid and organic acid ester methyl phenylacetate etc. 12
A compound can effectively break through sublingual vascular and enter affected area.
Ginseng has the function of inhibiting platelet aggregation, lure arachidonic acid, ADP, fibrin ferment and adrenaline etc.
The platelet aggregation of hair has significant inhibiting effect；PanaxosideRb2 can improve blood lipid, reduce blood cholesterol, triglycerides,
Serum High Density Lipoprotein Cholesterol is increased, atherogenic index is reduced, hyperlipidemia, thrombosis and artery sclerosis is controlled
Treat value.
Beneficial effect
Compared with prior art, the invention has the following advantages: sublingual Thrombolytic agent of the present invention, finished product are that can spray
Aqua is applied, without puncturing bleeding to sublingual and can remove extravasated blood, is promoted blood circulation so that extravasated blood toxin to be metabolized with body Xinchen
It excretes；The preparation method of preparation is simple, easy to produce, while the compatibility between each component, has the function of synergy；Benefit
It extracted with height brewing grains white spirit, dissolve effective component in each Chinese medicine, and be delivered to saliva gold cave, good wine cave, with thrombus.
Specific embodiment
The present invention will be further described combined with specific embodiments below, and the present embodiment is the technical scheme is that preceding
It mentions, gives detailed embodiment.
Embodiment 1
A kind of sublingual Thrombolytic agent, including following raw material: 3 parts of Radix Astragali, 5 parts of the root of Dahurain angelica, 5 parts of olibanum, 5 parts of myrrh, bone are broken
Benefit 5 parts, 5 parts of cloves, 3 parts of cortex cinnamomi, 5 parts of Rhizoma Chuanxiong, 10 parts of safflower, 15 parts of radix achyranthis bidentatae, 15 parts of Radix Salviae Miltiorrhizae, 8 parts of ginseng.
Sublingual Thrombolytic agent in the present embodiment is aqua, and preparation method includes:
1) by above-mentioned raw material cleaning, impurity elimination, dry and be crushed to powder, part weighs Chinese drugs powder according to the required weight；
2) raw material powder weighed in step 1) is placed in 65 ° of brewing grains white spirits brewed one month, primary liquor is obtained by filtration
Spare with brewed rear raw material, the amount of brewing grains white spirit described in this step and the total amount ratio of above-mentioned raw materials are 10:1；
3) traditional Chinese medicinal material raw materials under filtering in step 2 are rolled by juice press and is taken, and filtering and removing slag obtain second level liquor；
4) primary liquor and second level liquor are mixed, obtains sublingual Thrombolytic agent, and dispense.
Embodiment 2
Sublingual Thrombolytic agent described in the present embodiment further includes 3 parts of lanatechead saussurea herb with flower, 10 parts of leech, 3 parts of cordyceps sinensis, and sublingual molten
In the preparation method of bolt preparation by olibanum, do not have medicinal vinegar after crush；By leech, cordyceps sinensis air-dry after crush, and in other
It is brewed after medicinal raw material mixing.
Embodiment 3
Sublingual Thrombolytic agent described in the present embodiment, including following raw material: 8 parts of Radix Astragali, 8 parts of the root of Dahurain angelica, 10 parts of olibanum,
10 parts of myrrh, 10 parts of the rhizome of davallia, 8 parts of cloves, 8 parts of cortex cinnamomi, 10 parts of Rhizoma Chuanxiong, 25 parts of safflower, 30 parts of radix achyranthis bidentatae, 20 parts of Radix Salviae Miltiorrhizae, ginseng
15 parts, 5 parts of lanatechead saussurea herb with flower, 15 parts of leech, 5 parts of cordyceps sinensis.
Above-mentioned traditional Chinese medicinal material raw materials impurity elimination is cleaned, dries and is crushed to 0.5-1cm, and weighs among the above by above-mentioned parts by weight
Medicinal material raw material, wherein olibanum, myrrh crush after vinegar system.Above-mentioned raw material are placed in 75 ° of brewing grains white spirits brewed 3 months,
It filters to obtain primary liquor and brewed rear raw material, brewed rear raw material is rolled by juice press and are taken, second level liquid is obtained after filtering and removing slag
Agent mixes primary liquor and second level liquor, packing.
Embodiment 4
Sublingual Thrombolytic agent and preparation method thereof described in the present embodiment and sublingual Thrombolytic agent and its preparation side in embodiment 3
Method is essentially identical, the difference is that: the sublingual Thrombolytic agent formula includes following raw material: 5 parts of Radix Astragali, the root of Dahurain angelica
6 parts, 8 parts of olibanum, 8 parts of myrrh, 8 parts of the rhizome of davallia, 6 parts of cloves, 5 parts of cortex cinnamomi, 8 parts of Rhizoma Chuanxiong, 20 parts of safflower, 25 parts of radix achyranthis bidentatae, Radix Salviae Miltiorrhizae
18 parts, 12 parts of ginseng, 4 parts of lanatechead saussurea herb with flower, 12 parts of leech, 4 parts of cordyceps sinensis.
Application method: the sublingual Thrombolytic agent obtained after primary liquor and second level liquor are mixed is smeared or is sprayed on sublingual
Jinin cave and good wine cave, spue, twice daily after 10-30 minutes.
Heretofore described leech uses the Hirudo japonica of artificial pond raising, is during processing put into running water leech
It is added that 75 ° of white wine are bored kills in hermetically sealed can, then clear water is cleaned and dried, using as the leech raw material in medicinal material；Leech contains
A variety of amino acid and microelement necessary to human body, have in cardiovascular and cerebrovascular disease and have a better effect.Remember in ancient medical book
It is loaded with and treats a variety of diseases using leech, call that its master closes by extravesated blood, hemostasis, the moon, blood-breaking disperse accumulation is gathered ..., holy doctor Zhang Zhongjing uses it
Eliminating pathogen to support vital qi, the disease for the treatment of hemostasis, water knot, it is shown that its unique curative effect.Also containing heparin, antithromboxin, protein etc., anti-blood
Bolt element can prevent effect of the fibrin ferment to fibrinogen, hinder blood clotting, have prevention effect, while its to the formation of thrombus
Contained heparin also has blood coagulation resisting function.
Addition leech is brewed in component contained by heretofore described Chinese materia medica preparation makes telangiectasis, increases blood
Circulation, and alleviate arterial wall spasm, blood viscosity is reduced, cloves, which has, in prescription presses down solidifying promoting blood circulation and breaking stagnation special effects materials, in prescription
Lead to blood in conjunction with Rhizoma Chuanxiong, the synergistic effect such as analgesia not only enhances thrombolytic effect, but also promote human metabolism, improves and suffer from
Person's rehabilitation function.
Treat case:
Case 1: male, 66 years old, before spraying, frequency was dizzy, has hypertension history, and sees that tongue bottom blood vessel is coarse, color is black, blood vessel
Blocking is serious；This sublingual thrombolysis liquid is smeared after 30 minutes, sublingual vein lighter, sublingual vein is almost after continuing 2 courses for the treatment of
It does not see, petechia ecchymosis disappears, and tongue obviously limbers up, flexibly.
Case 2: female, 50 years old, before spraying, sublingual vein was full, and diameter thickening is about 3mm, and sublingual vein length is more than tongue
Frenulum stop and the tip of the tongue 3/5, and have hettocyrtosis.It sprays sublingual thrombolysis to spue after 15 minutes, vein lighter adheres to spraying
Sublingual vein is without obvious prominent sense after 1 month.
Case 3: female, 51 years old, before spraying, sublingual vein color was black, and has thick dendron branch, and the black length of vein color reaches the tip of the tongue.
By spraying, sucking this product, spue after 30 minutes, vein lighter after two courses for the treatment of is felt without prominent.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, though
So the present invention has been disclosed as a preferred embodiment, and however, it is not intended to limit the invention, any technology people for being familiar with this profession
Member, without departing from the scope of the present invention, when the technology contents using the disclosure above make a little change or modification
It is right according to the technical essence of the invention for the equivalent embodiment of equivalent variations, but without departing from the technical solutions of the present invention
Any simple modification, equivalent change and modification made by above embodiments, all of which are still within the scope of the technical scheme of the invention.
Claims (7)
1. a kind of sublingual Thrombolytic agent, which is characterized in that including following raw material: 3-8 parts of Radix Astragali, 5-8 parts of the root of Dahurain angelica, olibanum
5-10 parts, 5-10 parts of myrrh, 5-10 parts of the rhizome of davallia, 5-8 parts of cloves, 3-8 parts of cortex cinnamomi, 5-10 parts of Rhizoma Chuanxiong, 10-25 parts of safflower, ox
15-30 parts of knee, 15-20 parts of Radix Salviae Miltiorrhizae, 8-15 parts of ginseng.
2. a kind of sublingual Thrombolytic agent as described in claim 1, which is characterized in that further include following raw materials in part by weight: saussurea involucrata
Flower 3-5 parts, 10-15 parts of leech, 3-5 parts of cordyceps sinensis.
3. a kind of sublingual Thrombolytic agent as claimed in claim 2, which is characterized in that including column raw material: 3 parts of Radix Astragali,
5 parts of the root of Dahurain angelica, 5 parts of olibanum, 5 parts of myrrh, 5 parts of the rhizome of davallia, 5 parts of cloves, 3 parts of cortex cinnamomi, 5 parts of Rhizoma Chuanxiong, 10 parts of safflower, 15 parts of radix achyranthis bidentatae,
15 parts of Radix Salviae Miltiorrhizae, 8 parts of ginseng, 3 parts of lanatechead saussurea herb with flower, 10 parts of leech, 3 parts of cordyceps sinensis.
4. a kind of sublingual Thrombolytic agent as claimed in claim 3, it is characterised in that: the raw material it is brewed using organic solvent and
At.
5. a kind of sublingual Thrombolytic agent as claimed in claim 4, it is characterised in that: the weight ratio of above-mentioned raw materials and organic solvent
For 1:(10-20), the organic solvent is 65 ° of -75 ° of brewing grains white spirits.
6. the preparation method of sublingual Thrombolytic agent as described in any one of claim 1-3, which is characterized in that including walking as follows
It is rapid:
1) cleaning and crushing, by above-mentioned raw material impurity elimination, clean, dry and are crushed to powder or 0.5-1cm；And press above-mentioned weight
Part weighs the Chinese medicine raw material；
2) brewed, raw material are placed at least one brewed moon in brewing grains white spirit, filter to obtain primary liquor and brewed rear raw material；
3) it rolls, brewed rear raw material is rolled by juice press and are taken, filtering and removing slag obtain second level liquor；
4) it mixes, primary liquor and second level liquor is mixed, packing.
7. a kind of preparation method of sublingual Thrombolytic agent as claimed in claim 6, it is characterised in that: the olibanum, myrrh vinegar
It is crushed after system；It is crushed after leech, cordyceps sinensis are air-dried.
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Cited By (1)
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| CN110639003A (en) * | 2019-09-30 | 2020-01-03 | 张继光 | Sublingual thrombolytic peptide and processing method thereof |
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