CN110082553A - A kind of horizontal micro-fluidic syringe pump of multichannel and its control method - Google Patents
A kind of horizontal micro-fluidic syringe pump of multichannel and its control method Download PDFInfo
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- CN110082553A CN110082553A CN201910512604.7A CN201910512604A CN110082553A CN 110082553 A CN110082553 A CN 110082553A CN 201910512604 A CN201910512604 A CN 201910512604A CN 110082553 A CN110082553 A CN 110082553A
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- 238000000034 method Methods 0.000 title claims abstract description 9
- 230000007246 mechanism Effects 0.000 claims abstract description 37
- 230000001141 propulsive effect Effects 0.000 claims abstract description 34
- 238000009434 installation Methods 0.000 claims abstract description 30
- 238000002347 injection Methods 0.000 claims description 46
- 239000007924 injection Substances 0.000 claims description 46
- 238000001514 detection method Methods 0.000 claims description 26
- 230000033001 locomotion Effects 0.000 claims description 12
- 239000007853 buffer solution Substances 0.000 claims description 9
- 210000002421 cell wall Anatomy 0.000 claims description 9
- 239000012488 sample solution Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 16
- 239000000523 sample Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 239000000243 solution Substances 0.000 description 9
- 206010028980 Neoplasm Diseases 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000002493 microarray Methods 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 235000005121 Sorbus torminalis Nutrition 0.000 description 1
- 244000152100 Sorbus torminalis Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
- F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
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- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a kind of horizontal micro-fluidic syringe pump of multichannel and its control methods, including body and at least two propulsive mechanisms being arranged on body, the propulsive mechanism includes: the fixing body being fixed on the machine body, the mounting groove for accommodating syringe is offered on fixing body, and the first installation station for adapting to different size syringe jacket is provided in the mounting groove；The pushing block being slidably mounted on body is provided with the second installation station for adapting to different size syringe core rod on pushing block；It is arranged in the intracorporal drive member of machine, drive member includes driving motor and the feed screw that is connected in driving motor output shaft, and the feed screw is threaded on pushing block to drive pushing block mobile.The present invention has the characteristics that different specification of syringe adaptability are high.
Description
Technical field
The present invention relates to the technical field of Medical Instruments, in particular to the horizontal micro-fluidic syringe pump of a kind of multichannel and its control
Method processed.
Background technique
As people go deep into mechanism of tumor metastasis research, more and more people recognize tumour early diagnosis, in time
Treatment and prognosis detection, are reducing cancer mortality, reduce and control the importance in terms of cancer morbidity, more recognize to follow
The detection of ring tumour cell is suitable in early detection metastases, monitoring postoperative recurrence, assessment curative effect and prognosis, and selection
The great influence of individualized treatment etc..Therefore, more and more modern detecting development and applications are to circulating tumor cell
Detection field in.
Currently, the Chinese patent that application publication number is CN105861297A discloses a kind of circulating tumor cell detection chip
And its application, micro-fluidic chip is equipped at least three sample holes and at least three sample outlet holes, by that will contain circulating tumor cell
Blood sample injected by sample holes, buffer solution injected by another two sample holes, and cell enters capture microarray, due to
Surface marker and size are different, and circulating tumor cell and microarray realize multiple-contact, are finally captured.
Blood sample and buffer solution containing circulating tumor cell are respectively charged into syringe, but existing miniflow
Control syringe pump can only install the syringe of same model in different installation passages, push injection with the speed of Uniform provisions
Device causes the syringe adaptability for different size poor, therefore there are certain improvements.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of horizontal micro-fluidic injection of multichannel
Pump, has the characteristics that different specification of syringe adaptability are high.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of horizontal micro-fluidic syringe pump of multichannel, including body and at least two propulsive mechanisms being arranged on body, institute
Stating propulsive mechanism includes:
The fixing body being fixed on the machine body offers the mounting groove for accommodating syringe on fixing body, sets in the mounting groove
It is equipped with the first installation station for adapting to different size syringe jacket；
The pushing block being slidably mounted on body is provided with the second peace for adapting to different size syringe core rod on pushing block
Fill station；
It is arranged in the intracorporal drive member of machine, drive member includes driving motor and is connected in driving motor output shaft
Feed screw, the feed screw are threaded on pushing block to drive pushing block mobile.
Through the above technical solutions, when using the syringe pump, first by the blood sample containing circulating tumor cell and
Buffer solution is encased in syringe, and then said syringe is separately mounted on propulsive mechanism, and the first installation station will be infused
The housing of emitter is fixed, and the core bar of syringe is fixed the second installation station, and drive member drives pushing block mobile,
To realize the action of injection of syringe；
In the application, the setting of multiple propulsive mechanisms, and then can be realized multiple syringes and correspond to injection speed, targeted injection body
Long-pending injection demand so that injection system is more diversified, and installs station by above-mentioned first installation station and second
Setting improves the syringe pump for the suitable of syringe so that the syringe pump can adapt to syringe of different specifications and sizes and use
Ying Xing.
Preferably, the first installation station includes several arc grooves being arranged on the two sides cell wall of mounting groove, each
Arc groove has different radian sizes to adapt to the outside wall surface of syringe jacket, and the arc groove of big radian is located at the arc of small radian
The top of shape slot；
Several caulking grooves are also provided on the two sides cell wall of the mounting groove, each caulking groove has different groove widths, the housing of syringe
It is fitted in corresponding arc groove and the chimb of syringe jacket is entrenched in corresponding caulking groove.
Through the above technical solutions, the housing of syringe will directly fit when syringe is mounted on the first installation station
It on the arc groove of mounting groove, is adapted to complete syringe with the first installation station, and by by syringe jacket
Chimb is entrenched in corresponding caulking groove, improves stability of the syringe in the first installation station.
Preferably, the second installation station includes being provided with the container of pushing block end face and being provided with container
Several card slots on the cell wall of two sides, each card slot have different groove depths and groove width, the core bar of syringe be housed in container and
The chimb of syringe core rod is entrenched in corresponding card slot.
Through the above technical solutions, the second installation station is used for the core bar of mounting of syringe, by by syringe core rod
Chimb is entrenched in corresponding card slot, and the installation for syringe core rod can be realized, and convenience is high.
Preferably, compact heap is provided on the fixing body, offered on the compact heap for syringe jacket
Outside wall surface compatible seal face is provided with the strain component for tensing compact heap on the fixing body.
Through the above technical solutions, strain component is for tensing compact heap, by compact heap by syringe in mounting groove
It compresses, improves syringe mounting stability.
Preferably, the strain component includes the tie rod being plugged on fixing body and the drawing that is socketed on tie rod
Tight spring, one end of the back-moving spring is connected on tie rod and the other end is connected to the lower surface of fixing body；
The turnbuckle that end thread is connected on tie rod is plugged on the compact heap.
Through the above technical solutions, when needing mounting of syringe, it is only necessary to turnbuckle is pulled, by the way that syringe to be placed in
The lower section of compact heap the housing of syringe can be fixed by the elastic force of back-moving spring, and tense spiral shell by rotation
Bolt can be improved compact heap for the fixation dynamics of syringe, and the application is realized by back-moving spring and carried out to syringe jacket
It is fixed, thus while ensure that for syringe jacket fixing intensity, and avoid tightening force from belonging to rigid fixed form and make
At the deformation of syringe jacket, the action of injection of syringe is influenced.
Preferably, offered on the body for pushing block sliding sliding groove, the two sides of the pushing block offer with
The chimeric chimeric notch of the two sides trough rim of sliding groove.
Through the above technical solutions, the chimeric notch of pushing block two sides will be entrenched in when pushing block is slided along sliding groove
On the trough rim of sliding groove, to ensure that the stability of pushing block sliding, to improve the injection precision of syringe.
Preferably, it is provided with sliding rail in the body, sliding seat is slidably fitted on the sliding rail, it is described to push away
Motion block is fixed on sliding seat, and the feeding swivel nut being threadedly coupled for feed screw is provided on the sliding seat.
Through the above technical solutions, feed screw is threaded on feeding swivel nut, and then drive sliding seat along sliding
Track sliding improves the stability of pushing block sliding to realize the sliding action of pushing block.
Preferably, the sliding seat of gig is provided with detection block in the two sides of glide direction, in the body sliding seat most
Detection switch is respectively arranged at large sliding stroke and the minimum slip stroke, the detection switch with detection block for contacting to control
Driving motor movement processed.
Through the above technical solutions, detection switch is arranged in sliding seat maximum sliding stroke and the minimum slip stroke, thus
Guarantee that pushing block for the injection effect of syringe, avoids pushing block that syringe or pushing block excessively pull is excessively pushed to inject
Device causes the damage of syringe.
Preferably, the two sides of the body are rotatably equipped with support arm, and the support arm is used to support body so that machine
The injection port horizontal tilt for the syringe installed on body is down-set.
Through the above technical solutions, rotational support arm, the end of support arm can be contradicted on work top, so that body
It is inclined to set, so that the injection port horizontal tilt for the syringe installed on body is down-set, as a result, when being packed into syringe
When having the blood sample of circulating tumor cell, circulating tumor cell can be precipitated at accumulation to syringe injection port, so that circulation
Tumour cell can take the lead in being injected into micro-fluidic chip, improve detection accuracy, and circulating tumor cell residual mutually should be avoided
In syringe；
Wherein, rotational support arm can change the tilt angle of body, and then by the tilt angle of different syringes to adapt to
The blood sample of different viscosityes, i.e. circulating tumor cell and serum contain different proportion in blood sample.
In view of the deficiencies of the prior art, the present invention intends to provide a kind of horizontal micro-fluidic syringe pump of multichannel
Control method, have the characteristics that different specification of syringe adaptability are high.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of control method of the horizontal micro-fluidic syringe pump of multichannel as described in the above technical scheme, includes the following steps:
Configuration step: the volume gear, injection speed and targeted injection body of syringe used in each propulsive mechanism are configured
Product, and further configure the sequence of movement of each propulsive mechanism；
Sample and buffer solution: being encased in syringe by installation steps respectively, and syringe is installed to correspondence and is configured
In the propulsive mechanism of volume gear；
Injecting step: control propulsive mechanism starting carries out action of injection according to preset sequence of movement.
In conclusion the present invention having the beneficial effect that in contrast to the prior art
In the application, the setting of multiple propulsive mechanisms, and then can be realized multiple syringes and correspond to injection speed, targeted injection body
Long-pending injection demand so that injection system is more diversified, and installs station by above-mentioned first installation station and second
Setting improves the syringe pump for the suitable of syringe so that the syringe pump can adapt to syringe of different specifications and sizes and use
Ying Xing.
Detailed description of the invention
Fig. 1 is the first overall structure diagram of embodiment；
Fig. 2 is the second overall structure diagram of embodiment；
Fig. 3 is the first cross-sectional view of embodiment；
Fig. 4 is the second cross-sectional view of embodiment；
Fig. 5 is the structural schematic diagram of drive member in embodiment；
Fig. 6 is the structural schematic diagram of pushing block in embodiment；
Fig. 7 is the scheme of installation of support arm in embodiment；
Fig. 8 is the holding state schematic diagram of support arm in embodiment.
Appended drawing reference: 1, body；2, propulsive mechanism；21, fixing body；22, pushing block；23, drive member；231, driving electricity
Machine；232, feed screw；233, sliding rail；234, sliding seat；235, swivel nut is fed；24, mounting groove；25, the first erector
Position；251, arc groove；252, caulking groove；26, the second installation station；261, container；262, card slot；3, display panel；4, key
Panel；5, compact heap；6, seal face；7, strain component；71, tie rod；72, back-moving spring；73, anti-off-clip；74, screw thread depth
Hole；75, turnbuckle；8, sliding groove；9, it is fitted into notch；10, detection block；11, detection switch；12, support arm；13, anti-skid chequer
Road.
Specific embodiment
Below in conjunction with attached drawing, invention is further described in detail.
Currently, the blood sample containing circulating tumor cell and buffer solution be injected by micro-fluidic syringe pump micro-
When fluidic chip is detected, since micro-fluidic syringe pump can only install the injection of same model in different installation passages
Device pushes syringe with the speed of Uniform provisions, causes the syringe adaptability for different size poor.
For this purpose, the application improves micro-fluidic syringe pump, so that micro-fluidic syringe pump can adapt to different size note
Emitter is installed and used, and is formed multiple syringes while being used or single syringe is used alone, also can satisfy it is multiple not
The syringe of same specification is acted with defined injection speed, targeted injection volume.
Specifically, the present invention proposes a kind of horizontal micro-fluidic syringe pump of multichannel in order to solve the above problem, in conjunction with Fig. 1 and
Shown in Fig. 2, it is provided with including body 1 and at least two propulsive mechanisms 2 being arranged on body 1, the quantity of propulsive mechanism 2
Multiple, multiple propulsive mechanisms 2 are set according to user demand.Display panel 3 and key panel 4, body are provided on body 1
Main control chip is provided in 1, main control chip is connected with display panel 3 and key panel 4, and main control chip can be to propulsive mechanism 2
Form control.
Propulsive mechanism 2 includes fixing body 21, pushing block 22 and drive member 23.It is filled in syringe and contains circulating tumor
After the blood sample or buffer solution of cell, the outlet of syringe is connected in the injection port in micro-fluidic chip by conduit,
Syringe is pushed into mechanism 2 and fixes, and then propulsive mechanism 2 realizes the movement of pressing syringe, completes syringe for circulating tumor
The blood sample or buffer solution of cell are injected into the action of injection in micro-fluidic chip.
Fixing body 21 is bolted on body 1, and the peace for accommodating syringe jacket is offered on fixing body 21
Tankage 24, the arc-shaped setting of mounting groove 24, wherein for adapting to different size syringe jacket is provided in mounting groove 24
One installation station 25.Specifically, the first installation station 25 includes several arc grooves being arranged on the two sides cell wall of mounting groove 24
251, the quantity of arc groove 251 is according to user's sets itself.Each arc groove 251 has different radian sizes, different size
The housing of syringe has the outside wall surface of different radian sizes, radian size and the syringe jacket outside wall surface of arc groove 251
Radian size is adapted, and as a result, when the housing of syringe is housed in mounting groove 24, the syringe of different size can make
Its housing fits with corresponding arc groove 251 respectively.It is worth noting that the arc groove 251 of big radian is located at small radian
The top of arc groove 251.
Several caulking grooves 252 are also provided on the two sides cell wall of mounting groove 24, each caulking groove 252 has different groove widths, caulking groove
252 groove width is to adapt to the chimb of syringe jacket, and as a result, during installation, the housing of syringe is fitted in corresponding arc groove
After in 251, the chimb of syringe jacket is entrenched in corresponding caulking groove 252, to realize syringe jacket in the first erector
Fixation in position 25, and guarantee the fixed stability of syringe jacket, front and back, upper and lower, left and right displacement will not occur.
For the fixed effect for further increasing syringe jacket, in the application, it is provided with compact heap 5 on fixing body 21, presses
Tight block 5 is horizontal on mounting groove 24, is offered on compact heap 5 for seal face 6 compatible with the outside wall surface of syringe jacket,
Seal face 6 is adapted with arc-shaped setting with the shape of syringe jacket, wherein is provided on fixing body 21 and is compressed for tensing
The strain component 7 of block 5.
In conjunction with shown in Fig. 3 and Fig. 4, on the one hand the setting of strain component 7 can guarantee the fastening for syringe jacket
On the other hand power can be avoided and cause syringe jacket because of hard extruding force and deformation occurs.Specifically, strain component 7 includes
Tie rod 71 and back-moving spring 72.Tie rod 71 is plugged on fixing body 21, and tie rod 71 passes through fixing body 21 and its end
Portion is extend into body 1, and in one embodiment, the cross section of tie rod 71 is arranged in rectangle.Tie rod 71 is located in body 1
End there is anti-off-clip 73, back-moving spring 72 is socketed on tie rod 71, and one end of back-moving spring 72 is connected to tie rod 71
Anti- off-clip 73 on, the other end of back-moving spring 72 is connected to the lower surface of fixing body 21.Wherein, the end of tie rod 71 opens up
There is screw thread depth hole 74, the turnbuckle that end thread is connected on 71 screw thread depth hole 74 of tie rod is plugged on compact heap 5
75。
As a result, in mounting of syringe housing, it is necessary first to hold with a hand turnbuckle 75 and carry out pull lift action, band
Dynamic compact heap 5 is mobile, and then the housing of syringe is placed in mounting groove 24, unclamps turnbuckle 75, and back-moving spring 72 is
Compact heap 5 can be driven to be pressed on the outer of syringe to put on, realize the fixation of syringe jacket.Wherein, by screwing or unscrewing drawing
Tight bolt 75, can be realized adjusting of the compact heap 5 for syringe jacket pressing force.
Pushing block 22 is slidably mounted on body 1, wherein the sliding groove 8 slided for pushing block 22 is offered on body 1,
The two sides of the pushing block 22 offer the chimeric notch 9 chimeric with the two sides trough rim of sliding groove 8.It is arranged on pushing block 22 useful
In the second installation station 26 for adapting to different size syringe core rod.Syringe core rod is fixed in second installation station 26,
The moving direction of pushing block 22 and the injection direction of syringe are identical, drive pushing block 22 mobile by drive member 23, thus
Realize the action of injection of syringe.
Specifically, in conjunction with shown in Fig. 2 and Fig. 6, the second installation station 26 includes the container for being provided with 22 end face of pushing block
261 and several card slots 262 for being provided on 261 two sides cell wall of container, each card slot 262 there is different groove depths and groove width,
Each card slot 262 is corresponding with the syringe core rod chimb of each specification, and the core bar of syringe is housed in container 261 and infuses
The chimb of emitter core bar is entrenched in corresponding card slot 262.
It is worth noting that pushing the stability of syringe injection, injection speed, volume injected can to improve pushing block 22
Control, progress are higher.In the application, in conjunction with shown in Fig. 3 and Fig. 5, drive member 23 is arranged in body 1, and drive member 23 includes
Driving motor 231 and the feed screw 232 being connected on 231 output shaft of driving motor, feed screw 232 are threaded in
To drive pushing block 22 mobile on pushing block 22.Specifically, driving motor 231 is fixed by screws in body 1, driving motor
231 use servo motor, and main control chip is connected by motor-drive circuit with driving motor 231.
It is provided with sliding rail 233 in body 1, sliding seat 234 is slidably fitted on sliding rail 233, pushing block 22 is logical
It crosses bolt to be fixed on sliding seat 234, the feeding swivel nut 235 being threadedly coupled for feed screw 232 is provided on sliding seat 234.
The two sides that sliding seat 234 is located at glide direction are provided with detection block 10, slide in body 1 in 234 maximum of sliding seat
It is respectively arranged with mounting bar at stroke and the minimum slip stroke, detection switch 11, detection switch 11 are fixedly installed on mounting bar
For being contacted with detection block 10 to control the movement of driving motor 231.In one embodiment, detection switch 11 uses photoelectric sensing
Device.In another embodiment, detection switch 11 is using close switch.
The setting of detection switch 11 is in the maximum sliding stroke of sliding seat 234 and the minimum slip stroke, to guarantee pushing block 22
For the injection effect of syringe, avoids pushing block 22 from excessively pushing syringe or pushing block 22 excessively pull syringe, make
At the damage of syringe.
It is worth noting that in conjunction with shown in Fig. 1 and Fig. 7, the two sides of body 1 are rotatably equipped with support arm 12, the two of body 1
Side offers axis hole, integrally formed with the shaft being plugged in axis hole on support arm 12, close-fitting is used between shaft and axis hole
It closes, wherein non-slip texture 13 is distributed in the two side walls of body 1, non-slip texture 13 contradicts on the inner wall of support arm 12, turns
When dynamic support arm 12, support arm 12 can be stopped in any angle, and support arm 12 is used to support body 1 so that pacifying on body 1
The injection port horizontal tilt of the syringe of dress is down-set.
As a result, referring to figs. 7 and 8, the end of rotational support arm 12, support arm 12 can be contradicted in work top
On, so that body 1 is inclined to set, so that the injection port horizontal tilt for the syringe installed on body 1 is down-set, as a result,
When being incorporated with the blood sample of circulating tumor cell in syringe, circulating tumor cell can precipitate accumulation to syringe and inject
At mouthful, enables circulating tumor cell to take the lead in being injected into micro-fluidic chip, improve detection accuracy, circulation mutually should be avoided
Tumour cell remains in syringe；
Wherein, rotational support arm 12, can change the tilt angle of body 1, so by the tilt angle of different syringes with
The blood sample of different viscosityes is adapted to, i.e. circulating tumor cell and serum contains different proportion in blood sample.
Based on the above-mentioned technical proposal, a kind of control method of horizontal micro-fluidic syringe pump of multichannel is realized, including as follows
Step:
Configuration step: when micro-fluidic syringe pump horizontal using the multichannel, it is necessary first to be configured, be matched by key panel 4
Set the volume gear, injection speed and targeted injection volume of syringe used in each propulsive mechanism 2；
And the sequence of movement of each propulsive mechanism 2 is further configured, specifically, number is established for each propulsive mechanism 2, according to note
Demand is penetrated, propulsive mechanism 2 can be controlled according to the number order of regulation and is started one by one, is completed to syringe on propulsive mechanism 2
Action of injection, 2 synchronous averaging of propulsive mechanism that also can accordingly number according to the rules complete the injection of syringe on propulsive mechanism 2
Movement.
Blood sample containing circulating tumor cell and buffer solution: being encased in syringe by installation steps respectively,
And install syringe into the corresponding propulsive mechanism 2 for having configured volume gear, it is above-mentioned molten equipped with blood sample and buffering as a result,
The specification of syringe size of liquid can be different, installed by the propulsive mechanism 2 of the application to the syringe of different size, can also
Realize the injection demand of corresponding injection speed and targeted injection volume.
Injecting step: the start key on pressing keys panel 4 after main control chip receives enabling signal, controls pusher
Structure 2 starts, and carries out action of injection to control the propulsive mechanism 2 by configuration according to preset sequence of movement.
Wherein, main control chip can control driving motor 231 by key panel 4 and be resetted, and pass through detection switch 11
Setting stop so that the reset of pushing block 22 is rested at maximum sliding stroke or resetted to the minimum slip stroke.
In the application, the setting of multiple propulsive mechanisms 2, and then can be realized multiple syringes and correspond to injection speed, target
The injection demand of volume injected so that injection system is more diversified, and passes through above-mentioned first installation station 25 and the second peace
Fill the setting of station 26 so that the syringe pump can adapt to syringe of different specifications and sizes and use, improve the syringe pump for
The adaptability of syringe.
The above is only exemplary embodiment of the invention, protection scope and is not intended to limit the present invention, this hair
Bright protection scope is determined by the attached claims.
Claims (10)
1. a kind of horizontal micro-fluidic syringe pump of multichannel, including body (1) and what is be arranged on body (1) at least two pushed away
Into mechanism (2), which is characterized in that the propulsive mechanism (2) includes:
The fixing body (21) being fixed on body (1) offers the mounting groove (24) for accommodating syringe on fixing body (21),
The first installation station (25) for adapting to different size syringe jacket is provided in the mounting groove (24)；
The pushing block (22) being slidably mounted on body (1), pushing block are provided on (22) for adapting to different size syringe
Second installation station (26) of core bar；
The drive member (23) being arranged in body (1), drive member (23) include driving motor (231) and are connected to drive
Feed screw (232) on dynamic motor (231) output shaft, the feed screw (232) be threaded on pushing block (22) with
Drive pushing block (22) mobile.
2. the horizontal micro-fluidic syringe pump of a kind of multichannel according to claim 1, which is characterized in that first erector
Position (25) includes several arc grooves (251) being arranged on the two sides cell wall of mounting groove (24), and each arc groove (251) has not
With radian size to adapt to the outside wall surface of syringe jacket, the arc groove (251) of big radian is located at the arc groove of small radian
(251) top；
It is also provided with several caulking grooves (252) on the two sides cell wall of the mounting groove (24), each caulking groove (252) has different slots
Width, the housing of syringe is fitted in corresponding arc groove (251) and the chimb of syringe jacket is entrenched in corresponding caulking groove
(252) in.
3. the horizontal micro-fluidic syringe pump of a kind of multichannel according to claim 1, which is characterized in that second erector
Position (26) includes being provided with the container (261) of pushing block (22) end face and being provided on the cell wall of container (261) two sides
Several card slots (262), each card slot (262) have different groove depths and groove width, and the core bar of syringe is housed in container (261)
And the chimb of syringe core rod is entrenched in corresponding card slot (262).
4. the horizontal micro-fluidic syringe pump of a kind of multichannel according to claim 1, which is characterized in that the fixing body (21)
On be provided with compact heap (5), offer on the compact heap (5) for seal face compatible with the outside wall surface of syringe jacket
(6), the strain component (7) for tensing compact heap (5) is provided on the fixing body (21).
5. the horizontal micro-fluidic syringe pump of a kind of multichannel according to claim 4, which is characterized in that the strain component
It (7) include the tie rod (71) being plugged on fixing body (21) and the back-moving spring (72) being socketed on tie rod (71), institute
The one end for stating back-moving spring (72) is connected on tie rod (71) and the other end is connected to the lower surface of fixing body (21)；
The turnbuckle (75) that end thread is connected on tie rod (71) is plugged on the compact heap (5).
6. the horizontal micro-fluidic syringe pump of a kind of multichannel according to claim 1, which is characterized in that on the body (1)
The sliding groove (8) for pushing block (22) sliding is offered, the two sides of the pushing block (22) offer and the two sides of sliding groove (8)
The chimeric chimeric notch (9) of trough rim.
7. the horizontal micro-fluidic syringe pump of a kind of multichannel according to claim 6, which is characterized in that in the body (1)
It is provided with sliding rail (233), is slidably fitted with sliding seat (234) on the sliding rail (233), the pushing block (22) is solid
It is scheduled on sliding seat (234), the feeding swivel nut being threadedly coupled for feed screw (232) is provided on the sliding seat (234)
(235)。
8. the horizontal micro-fluidic syringe pump of a kind of multichannel according to claim 7, which is characterized in that the sliding seat
(234) it is provided with detection block (10) positioned at the two sides of glide direction, in the maximum sliding row of sliding seat (234) in the body (1)
It is respectively arranged at journey and the minimum slip stroke detection switch (11), the detection switch (11) with detection block (10) for contacting
To control driving motor (231) movement.
9. the horizontal micro-fluidic syringe pump of a kind of multichannel according to claim 1, which is characterized in that the body (1)
Two sides are rotatably equipped with support arm (12), and the support arm (12) is used to support body (1) so that the note installed on body (1)
The injection port horizontal tilt of emitter is down-set.
10. a kind of control method of the horizontal micro-fluidic syringe pump of multichannel as described in claim 1 ~ 9 any one, feature
It is, includes the following steps:
Configuration step: volume gear, injection speed and the target note of syringe used in each propulsive mechanism (2) are configured
Beam product, and further configure the sequence of movement of each propulsive mechanism (2)；
Sample and buffer solution: being encased in syringe by installation steps respectively, and syringe is installed to correspondence and is configured
In the propulsive mechanism (2) of volume gear；
Injecting step: control propulsive mechanism (2) starting carries out action of injection according to preset sequence of movement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910512604.7A CN110082553A (en) | 2019-06-13 | 2019-06-13 | A kind of horizontal micro-fluidic syringe pump of multichannel and its control method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910512604.7A CN110082553A (en) | 2019-06-13 | 2019-06-13 | A kind of horizontal micro-fluidic syringe pump of multichannel and its control method |
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ID=67424245
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| CN201910512604.7A Pending CN110082553A (en) | 2019-06-13 | 2019-06-13 | A kind of horizontal micro-fluidic syringe pump of multichannel and its control method |
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| CN (1) | CN110082553A (en) |
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