CN112275213A - Stem cell gel particle generation instrument - Google Patents
Stem cell gel particle generation instrument Download PDFInfo
- Publication number
- CN112275213A CN112275213A CN202011305504.6A CN202011305504A CN112275213A CN 112275213 A CN112275213 A CN 112275213A CN 202011305504 A CN202011305504 A CN 202011305504A CN 112275213 A CN112275213 A CN 112275213A
- Authority
- CN
- China
- Prior art keywords
- stem cell
- cell gel
- raw material
- channel
- gel particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/0052—Preparation of gels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The application belongs to the technical field of stem cell gel particle preparation. The application provides a stem cell gel particle generator, wherein the flow rate of feed liquid is controlled by a control module and a driving module, stem cell gel particles are formed by combining the control of a microfluidic chip, the preparation process is integrated, the rapid and large-flux manufacturing can be realized, the preparation speed is about one hundred million/time, and the high demand of biological 3D printing technology in the future medical industry on stem cell particle raw materials is facilitated; the production efficiency is improved, the structural design is simplified, and the cost for manufacturing the instrument is reduced. The utility model provides a stem cell gel particle generates appearance can control drive module's one end through control module and stretch into the intercommunication mouth of raw material tank, pushes feed liquid in the raw material tank in the feedstock channel, and control drive module and push feed channel's speed, and then the material speed is thrown in the control, can adjust the size and the shape that stem cell gel particle generated to adapt to the preparation of the stem cell gel particle of different cell growth conditions.
Description
Technical Field
The application belongs to the technical field of preparation of stem cell gel particles, and particularly relates to a stem cell gel particle generator.
Background
The stem cell gel particles mainly provide hydrogel-loaded cells for cells and medicines, and can be widely applied to biomedical treatment, beauty industry and laboratories of colleges and universities. In the prior art, instruments capable of producing stem cell gel particles comprise a three-dimensional scaffold stem cell culture instrument equipment system, an ink-jet type stem cell gel particle forming machine and an electrostatic spinning stem cell gel particle forming machine.
The three-dimensional support stem cell culture instrument equipment system has higher requirement on equipment and is inflexible to use, raw materials cannot be used for production and manufacturing in real time, the raw materials need to be added after being pretreated, the raw materials cannot be added into the instrument and the materials after collection and preparation can not be carried out simultaneously, the fusion time of the materials cannot be controlled, and the waste of the raw materials is caused. The ink-jet type stem cell gel particle forming machine is prepared by a jet shearing method, the electrostatic spinning stem cell gel particle forming machine is prepared by an electrostatic granulation method, and the preparation speed is slow, about one hundred thousand cells per time, the preparation cost is high, and the flexible use cannot be realized.
Disclosure of Invention
In view of this, the present application provides a stem cell gel particle generating apparatus, which integrally performs raw material and production, improves production efficiency, and has a simple structure.
The specific technical scheme of the application is as follows:
a stem cell gel particle generator comprises a box body, a control module, a driving module and a micro-fluidic chip, wherein the control module, the driving module and the micro-fluidic chip are arranged on the box body;
the box body is provided with a raw material box and a collecting box;
the microfluidic chip comprises a feeding channel and a discharging channel;
the discharge channel is communicated with the feed inlet of the collecting box, and the feed channel is communicated with the discharge outlet of the raw material box;
one end of the driving module can extend into the communication port of the raw material box and is movably connected with the raw material box, so that the material liquid is pushed into the feeding channel;
the control module is electrically connected with the driving module and controls the pushing speed of the driving module.
Preferably, the driving module comprises a motor, a driver and a linkage rod;
the motor is fixedly arranged on the side wall of the box body and connected with the driver to drive the driver to rotate along the central axis;
the first end of the linkage rod is movably connected with the driver, and the second end of the linkage rod is driven to be gradually pushed into the raw material box under the rotation of the driver.
Preferably, the transmission comprises a gear and a driving rod;
the edge of the gear is connected with the motor in a jogged mode, and the driving rod penetrates through the circle center of the gear and is fixedly connected with the gear along the direction of the central axis of the gear;
the first end of the linkage rod is movably connected with the driving rod.
Preferably, a flat plate is fixedly arranged at the first end of the linkage rod, a through hole is formed in the flat plate, and the through hole is in threaded connection with the driver;
and the driver drives the linkage rod to be pushed forward through the flat plate in the rotating process.
Preferably, the control module comprises a single chip microcomputer and a control panel;
the single chip microcomputer is arranged on the motor and controls the rotating speed of the motor;
the control panel is arranged on the outer side of the box body, and can control and display the speed of the linkage rod pushing into the raw material box.
Preferably, the second end of trace is equipped with the shutoff portion, raw material tank is equipped with the storage passageway, the shutoff portion with the sealed cooperation in bottom of storing the passageway.
Preferably, the number of the storage channels is four, the four storage channels are independent of each other, and the four storage channels correspond to the four linkage rods respectively and are communicated with the four feeding channels respectively.
Preferably, the feed inlet of the collection box and the communication port of the raw material box are on the same side relative to the feed channel.
Preferably, the device further comprises a top cover;
the first end of top cap is in the intercommunication mouth top of former feed tank with former feed tank rotates to be connected, the second end of top cap is in the discharge gate top of former feed tank with former feed tank block is connected.
Preferably, the fixing groove is further included;
the first end of the fixed groove is rotatably connected with the box body and is provided with a socket for inserting the microfluidic chip, and the second end of the fixed groove is detachably connected with the box body through a support.
In summary, the application provides a stem cell gel particle generator, which controls the flow rate of feed liquid through a control module and a driving module, integrates a micro-fluidic chip to control and form stem cell gel particles, integrates the preparation process into a whole, can realize rapid and large-flux manufacture, has about one hundred million preparation speeds per time, and is beneficial to the high demand of biological 3D printing technology in the future medical industry on stem cell particle raw materials; the production efficiency is improved, the structural design is simplified, and the cost for manufacturing the instrument is reduced. The utility model provides a stem cell gel particle generates appearance can control drive module's one end through control module and stretch into the intercommunication mouth of raw material tank, pushes feed liquid in the raw material tank in the feedstock channel, and control drive module and push feed channel's speed, and then the material speed is thrown in the control, can adjust the size and the shape that stem cell gel particle generated to adapt to the preparation of the stem cell gel particle of different cell growth conditions.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without inventive exercise.
FIG. 1 is a perspective view showing the external configuration of a stem cell gel particle generator provided in the present application;
FIG. 2 is a perspective view showing the internal configuration of the stem cell gel particle generator provided in the present application;
FIG. 3 is a front view showing the internal configuration of the stem cell gel particle generator provided in the present application;
FIG. 4 is a top view of the internal structure of the stem cell gel particle generator provided in the present application;
fig. 5 is a schematic structural diagram of a microfluidic chip of the stem cell gel particle generator provided in the present application.
Illustration of the drawings: 1. a box body; 12. a raw material tank; 13. a collection box; 14. a communication port; 15. a storage channel; 2. a control module; 21. a single chip microcomputer; 22. a control panel; 3. a drive module; 31. a motor; 32. a gear; 33. a drive rod; 34. a linkage rod; 35. a flat plate; 4. a microfluidic chip; 41. a first feed channel; 42. a second feed channel; 43. a third feed channel; 44. a fourth feed channel; 45. a first discharge channel; 46. a second discharge channel; 47. a first mixing chamber; 48. a second mixing chamber; 49. a third mixing chamber; 5. a top cover; 6. and fixing the grooves.
Detailed Description
In order to make the objects, features and advantages of the present application more obvious and understandable, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is apparent that the embodiments described below are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Referring to fig. 1 and 2, fig. 1 is a perspective view of an external configuration of the stem cell gel particle generator provided in the present application, and fig. 2 is a perspective view of an internal configuration of the stem cell gel particle generator provided in the present application.
The embodiment of the application provides a stem cell gel particle generator, which comprises a box body 1, and a control module 2, a driving module 3 and a micro-fluidic chip 4 which are arranged on the box body 1; the box body 1 is provided with a raw material box 12 and a collecting box 13; the micro-fluidic chip 4 comprises a feeding channel and a discharging channel; the discharge channel is communicated with a feed inlet of the collection box 13, and the feed channel is communicated with a discharge outlet of the raw material box 12; one end of the driving module 3 can extend into the communication port 14 of the raw material box 12 and is movably connected with the raw material box 12, so that the material liquid is pushed into the feeding channel; the control module 2 is electrically connected with the driving module 3 and controls the pushing speed of the driving module 3.
In the embodiment of the application, the flow rate of the feed liquid is controlled by the control module 2 and the driving module 3, the stem cell gel particles are formed by combining the control of the microfluidic chip 4, the preparation process is integrated, the rapid and large-flux manufacturing can be realized, the preparation speed is about one hundred million/time, and the high demand of the biological 3D printing technology in the future medical industry on the raw materials of the stem cell particles is facilitated; the production efficiency is improved, the structural design is simplified, and the cost for manufacturing the instrument is reduced. The utility model provides a stem cell gel particle generates appearance can control the one end of drive module 3 through control module 2 and stretch into the intercommunication mouth 14 of former feed tank 12, pushes the feed liquid in the former feed tank 12 into feedstock channel, and controls the speed that drive module 3 pushed into feedstock channel, and then the material speed is thrown in the control, size and shape that can adjust the generation of stem cell gel particle to the preparation of the stem cell gel particle of the different cell growth conditions of adaptation.
The utility model provides a stem cell gel granule generates appearance when using, pour the raw materials into raw materials case 12 earlier, open control module 2, control drive module 3 pushes into feedstock channel with the certain speed of feed liquid, wherein, drive module 3's one end stretches into raw materials case 12 back, can extrude liquid from the discharge gate of raw materials case 12 through the extruded mode of volume, also can set up the chamber way that suits with drive module 3's appearance in raw materials case 12, drive module 3 releases the feed liquid from the chamber way. The raw materials finally form stem cell gel particles in the microfluidic chip 4 through a series of flow channels, wherein the microfluidic chip 4 can be a conventional commercially available stem cell microfluidic chip 4, and the formed stem cell gel particles and the waste materials generated by preparation are discharged into the collection box 13 through the discharge channel. When one end of the driving module 3 can not extend into the raw material box 12, the control module 2 controls the driving module 3 to return to the original position, and at the moment, raw materials are supplemented into the raw material box 12, and the preparation can be continued.
Referring to fig. 2 to 4, fig. 3 is a front view of an internal structure of the stem cell gel particle generator provided by the present application, and fig. 4 is a top view of the internal structure of the stem cell gel particle generator provided by the present application.
Further, the driving module 3 includes a motor 31, a driver, and a linkage 34; the motor 31 is fixedly arranged on the side wall of the box body 1 and connected with the driver to drive the driver to rotate along the central axis; the first end of the linkage rod 34 is movably connected with the driver, and the second end of the linkage rod 34 is driven to be gradually pushed into the raw material box 12 under the rotation of the driver.
In the embodiment of the application, the motor 31 drives the driver to rotate, and in the process of rotating the driver, the connection part of the linkage rod 34 and the driver continuously moves forward, so that the linkage rod 34 enters from the communication port 14 of the raw material box 12 and is gradually pushed in, and the material body in the raw material box 12 is squeezed into the feeding channel of the microfluidic chip 4. The driving mode of the motor 31, the driver and the linkage 34 is simple in structural design and easy to operate, and the driver and the linkage 34 can be detached and are convenient to clean and replace. Meanwhile, the pushing speed of the linkage rod 34 is adjusted by using the rotating shaft of the driver, so that the stability and the accuracy of the element in the operation process are enhanced.
Further, the transmission includes a gear 32 and a drive rod 33; the edge of the gear 32 is embedded and connected with the motor 31, and the driving rod 33 passes through the center of the gear 32 and is fixedly connected with the gear 32 along the central axis direction of the gear 32; the first end of the linkage 34 is movably connected with the driving rod 33.
In the embodiment of the application, the gear 32 is used for realizing transmission, so that the flow velocity of the material liquid in the preparation process can be adjusted on the premise of not changing the power of the motor 31 according to actual production requirements. The gear 32 with larger diameter and more teeth is replaced, which is beneficial to improving the accuracy of flow rate control; the replacement of the smaller diameter gear 32 helps to increase the range of options for controlling the flow rate. The gear 32 and the driving rod 33 are matched for use, so that the mechanical structure of the instrument is not changed, the preparation efficiency is improved, and the application range of the instrument is expanded.
Further, a flat plate 35 is fixedly arranged at the first end of the linkage rod 34, a through hole is formed in the flat plate 35, and the through hole is in threaded connection with the driver; during the rotation of the driver, the linkage rod 34 is driven by the flat plate 35 to push forwards.
In this application embodiment, actuating lever 33 is equipped with the external screw thread, and the through-hole is equipped with the internal thread, and actuating lever 33 is at rotatory in-process, and dull and stereotyped 35's frame is spacing by box 1, does not take place rotatoryly, and dull and stereotyped 35 drives trace 34 and is translational motion along the length direction of actuating lever 33 to the second end of control trace 34 stretches into raw materials case 12 and extrudes the feed liquid into in the raw materials passageway. The driving rod 33 and the linkage rod 34 are simply and easily connected by threads, and the components are easy to replace, thereby being beneficial to disassembly, assembly and maintenance. The linkage rod 34 and the driving rod 33 are driven by the flat plate 35 to improve the stability of translation, and further improve the precision of the propelling speed.
Further, the control module 2 comprises a single chip 21 and a control panel 22; the singlechip 21 is arranged on the motor 31 and controls the rotating speed of the motor 31; the control panel 22 is installed outside the box 1, and the control panel 22 can control and display the speed of pushing the linkage rod 34 into the raw material box 12.
In the embodiment of the present application, the single chip microcomputer 21 is a conventional commercially available product, and is installed above the motor 31 so as to adjust the rotation speed of the motor 31. A control button and a display screen can be arranged on the control panel 22, the control panel 22 can be electrically connected with the singlechip 21, and a user sets the pushing speed of the linkage rod 34, namely the rotating speed of the motor 31 through the control button, so that the gel generation speed and the size of liquid drops are controlled; the pushing speed of the linkage rod 34 can also be displayed on a display screen through signal analysis of the singlechip 21, so that a user can conveniently control the parameters and the progress of the current preparation process in real time, and man-machine interaction can be completed in time.
Further, the second end of the linkage 34 is provided with a blocking portion, the raw material tank 12 is provided with a storage channel 15, and the blocking portion is in sealing fit with the bottom of the storage channel 15.
In this application embodiment, the shutoff portion can be made by the stable flexible material of chemical property, can seal the cooperation with the bottom of storing passageway 15, improves the leakproofness of storing passageway 15 to improve the precision of the material liquid measure of pushing into raw materials passageway, still avoid simultaneously that trace 34 does not efficient stirring, improve the propulsive efficiency of transmission.
Further, the number of the storage channels 15 is four, the four storage channels 15 are independent of each other, and the four storage channels 15 correspond to the four linkage rods 34 respectively and are communicated with the four feeding channels respectively.
In the embodiment of the present application, four independent storage channels 15 may be disposed in the raw material tank 12, and are used to store different phases or feed liquid to be separated before preparation, so as to ensure that the raw material is not contaminated and quantitative determination of the raw material can be performed. The four linkage bars 34 can be fixed by the flat plate 35 and pushed in together at the same speed under the translation action of the flat plate 35, and the four linkage bars 34 can also be respectively movably connected with the four actuators and pushed in at different starting times and different speeds. In addition, the inner diameters of the four storage channels 15 can be different from each other, the storage channels 15 with different inner diameters and the adaptive linkage rods 34 can be replaced according to different preparation requirements, and the larger the inner diameter is, the larger the flow velocity generated under the pushing action is, so that the microstructure size of the prepared stem cell gel particles can be adjusted. Wherein, the four storage channels 15 can be respectively used for storing sodium alginate solution, calcium chloride solution, oil phase with biocompatibility and medicine solution containing calcium ions.
Referring to fig. 5, fig. 5 is a schematic structural diagram of a microfluidic chip of the stem cell gel particle generator provided in the present application. In the microfluidic chip 4, the feed channels include a first feed channel 41, a second feed channel 42, a third feed channel 43, and a fourth feed channel 44, and the discharge channels include a first discharge channel 45 and a second discharge channel 46. The first feed channel 41 can be fed with sodium alginate solution, the second feed channel 42 can be fed with calcium chloride solution, the third feed channel 43 can be fed with oil phase with biocompatibility, and the fourth feed channel 44 can be fed with drug solution containing calcium ions. The feed liquid in one storage channel 15 can flow separately into the feed channels at different positions, for example, two first feed channels 41 before the first mixing chamber 47 and before the third mixing chamber 49. The preparation process in the microfluidic chip 4 is as follows:
firstly, stem cells are dissolved in a sodium alginate solution and/or a calcium chloride salt solution, the sodium alginate solution and the calcium chloride salt solution are subjected to ion exchange in a first mixing chamber 47 to gelatinize alginate, and simultaneously, the alginate solution and the calcium chloride salt solution are mixed into an oil phase to form rod-shaped gel through flow channel plasticity. Then, a drug solution containing calcium ions is introduced into the second mixing chamber 48, wherein the drug solution is an inducer for the stem cells to perform directional differentiation, the oil phase of the rod-shaped gel is separated and removed, and the gel with the microstructures enters the water phase of the drug solution to achieve oil removal. Finally, calcium ions are mixed into the water phase of the medicine solution wrapping the gel, sodium alginate solution is mixed into the two sides of the medicine solution, the outermost layer of the gel is wrapped in the third mixing chamber 49 through oil phase wrapping, and the stem cell gel particles which are the cell culture solution, the inner layer of the gel, the medicine solution and the outer layer of the gel are formed in sequence from inside to outside. According to the properties of the stem cell gel particles prepared according to the requirements, the microfluidic chip 4 with different flow channel diameters and lengths can be flexibly replaced, so that the internal structure of the generated stem cell gel particles can be adjusted.
Further, the feed port of the collection tank 13 and the communication port 14 of the raw material tank 12 are on the same side with respect to the feed passage.
In the embodiment of the application, the feed liquid flows to the discharge hole, the feeding channel and the discharging channel of the raw material box 12 from the communicating port 14 in sequence, wherein the horizontal direction is changed at the feeding channel, the collecting box 13 is arranged in the middle of the instrument, the structural design saves space, and the reaction flow channel in the micro-fluidic chip 4 can be prolonged to adapt to the preparation of stem cell gel particles with different properties.
Further, the device also comprises a top cover 5; the first end of the top cover 5 is rotatably connected to the raw material tank 12 above the communication port 14 of the raw material tank 12, and the second end of the top cover 5 is engaged with the raw material tank 12 above the discharge port of the raw material tank 12.
In the embodiment of the present application, the top cover 5 may be provided with openings corresponding to the storage channels 15 one to one. The opening of the top cover 5 can facilitate the observation of the liquid level condition of the feed liquid in the storage channel 15 by a user, and the feed liquid can be timely supplemented through the opening. The first end of top cap 5 can be articulated with raw materials box 12 above intercommunication mouth 14 of raw materials box 12, and the second end of top cap 5 can pass through buckle fixed connection with raw materials box 12 above the discharge gate of raw materials box 12. Closed with top cap 5 and raw material tank 12's top in the preparation process, can play dustproof effect, top cap 5 has certain rigidity moreover, can play the effect that supports and stabilize raw material tank 12, prevents that the storage passageway 15 in the raw material tank 12 that leads to the interior subassembly collision in the preparation from producing the push that slightly deforms and hinder trace 34.
Further, the device also comprises a fixing groove 6; the first end of the fixed groove 6 is rotatably connected with the box body 1 and is provided with a socket for inserting the microfluidic chip 4, and the second end of the fixed groove 6 is detachably connected with the box body 1 through a bracket (not shown).
In the embodiment of the present application, the fixing groove 6 is used for loading and fixing the microfluidic chip 4, so as to improve the stability of the microfluidic chip 4. On box 1 was located to the first end of fixed slot 6, the second end was supported fixedly by the support of locating on the box 1 to can dismantle with box 1 through the support and be connected, can change the height of 6 second ends of fixed slot through the angle of adjusting the support, thereby change micro-fluidic chip 4's inclination, make feed channel highly be a little higher than discharge channel, can accelerate the interior feed liquid of micro-fluidic chip 4 and flow, improve preparation efficiency. In addition, an automatic loading and unloading assembly electrically connected with the control module 2 can be arranged in the fixing groove 6, and a user can control the operation of the automatic loading and unloading assembly through a control button. The automatic loading and unloading assembly can enable the microfluidic chip 4 to be partially ejected from the socket, or enable the microfluidic chip 4 to be completely clamped into the fixing groove 6 to complete loading and fixing, so that the loading, unloading and fixing of the microfluidic chip 4 are facilitated.
The above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions in the embodiments of the present application.
Claims (10)
1. The stem cell gel particle generator is characterized by comprising a box body, and a control module, a driving module and a micro-fluidic chip which are arranged on the box body;
the box body is provided with a raw material box and a collecting box;
the microfluidic chip comprises a feeding channel and a discharging channel;
the discharge channel is communicated with the feed inlet of the collecting box, and the feed channel is communicated with the discharge outlet of the raw material box;
one end of the driving module can extend into the communication port of the raw material box and is movably connected with the raw material box, so that the material liquid is pushed into the feeding channel;
the control module is electrically connected with the driving module and controls the pushing speed of the driving module.
2. The stem cell gel particle generator of claim 1, wherein the driving module comprises a motor, an actuator and a linkage;
the motor is fixedly arranged on the side wall of the box body and connected with the driver to drive the driver to rotate along the central axis;
the first end of the linkage rod is movably connected with the driver, and the second end of the linkage rod is driven to be gradually pushed into the raw material box under the rotation of the driver.
3. The stem cell gel particle generator of claim 2, wherein the actuator comprises a gear and a drive rod;
the edge of the gear is connected with the motor in a jogged mode, and the driving rod penetrates through the circle center of the gear and is fixedly connected with the gear along the direction of the central axis of the gear;
the first end of the linkage rod is movably connected with the driving rod.
4. The apparatus for generating stem cell gel particles as claimed in claim 2, wherein a plate is fixed to a first end of the linkage rod, the plate is provided with a through hole, and the through hole is in threaded connection with the actuator;
and the driver drives the linkage rod to be pushed forward through the flat plate in the rotating process.
5. The apparatus of claim 2, wherein the control module comprises a single-chip microcomputer and a control panel;
the single chip microcomputer is arranged on the motor and controls the rotating speed of the motor;
the control panel is arranged on the outer side of the box body, and can control and display the speed of the linkage rod pushing into the raw material box.
6. The apparatus as claimed in claim 2, wherein the second end of the linkage rod is provided with a blocking portion, the raw material tank is provided with a storage channel, and the blocking portion is in sealing fit with the bottom of the storage channel.
7. The apparatus as claimed in claim 6, wherein the number of the storage channels is four, the four storage channels are independent of each other, and the four storage channels correspond to the four linkage rods respectively and are communicated with the four feeding channels respectively.
8. The apparatus for producing stem cell gel particles according to claim 1, wherein the feed port of the collection tank and the communication port of the raw material tank are on the same side with respect to the feed channel.
9. The stem cell gel particle generator of claim 1, further comprising a top cover;
the first end of top cap is in the intercommunication mouth top of former feed tank with former feed tank rotates to be connected, the second end of top cap is in the discharge gate top of former feed tank with former feed tank block is connected.
10. The apparatus for generating stem cell gel particles according to claim 1, further comprising a fixing groove;
the first end of the fixed groove is rotatably connected with the box body and is provided with a socket for inserting the microfluidic chip, and the second end of the fixed groove is detachably connected with the box body through a support.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011305504.6A CN112275213A (en) | 2020-11-19 | 2020-11-19 | Stem cell gel particle generation instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011305504.6A CN112275213A (en) | 2020-11-19 | 2020-11-19 | Stem cell gel particle generation instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112275213A true CN112275213A (en) | 2021-01-29 |
Family
ID=74399311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011305504.6A Pending CN112275213A (en) | 2020-11-19 | 2020-11-19 | Stem cell gel particle generation instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112275213A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114260035A (en) * | 2021-12-23 | 2022-04-01 | 广东工业大学 | Multilayer-wrapped micro-fluidic chip and cell particle generator |
-
2020
- 2020-11-19 CN CN202011305504.6A patent/CN112275213A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114260035A (en) * | 2021-12-23 | 2022-04-01 | 广东工业大学 | Multilayer-wrapped micro-fluidic chip and cell particle generator |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104840272A (en) | Printing method for three-dimensional biological structure with built-in nutrition channel | |
| CN112275213A (en) | Stem cell gel particle generation instrument | |
| CN214233923U (en) | Stem cell gel particle generation instrument | |
| CN112237881A (en) | Multifunctional stirring device for bio-pharmaceuticals | |
| CN109731511A (en) | A kind of shower cream production stirring system | |
| CN113322526A (en) | Regenerated cellulose spinning solution manufacturing device | |
| CN112622084A (en) | Mixing and batching device for producing weather-resistant master batches | |
| CN114229107B (en) | Speed adjusting device for gel injection | |
| CN211159666U (en) | Reaction kettle for drug synthesis | |
| CN116571158A (en) | Mixing device for recombinant collagen gel dressing production | |
| CN217431545U (en) | Mixing arrangement is used in pesticide production | |
| CN213500162U (en) | Be used for special agitating unit of silicone-chitosan complex film | |
| CN212119786U (en) | Constant temperature incubator for biological medicine | |
| CN213556430U (en) | In-vitro diagnostic reagent material preparation device | |
| CN214031705U (en) | Controllable minute liquid cover of bio-pharmaceuticals velocity of flow | |
| CN220482600U (en) | Biological 3D prints shower nozzle | |
| CN218393188U (en) | Medicine concentration regulator | |
| CN215516766U (en) | Automatic quantitative dosing and disinfecting device for water treatment | |
| CN215506552U (en) | Synthetic for biological medicine medicament mixing arrangement | |
| CN219721964U (en) | Crystallization tank capable of discharging in batches | |
| CN217614585U (en) | Extrusion production device for granular insecticide-fertilizer containing chlorantraniliprole and cyfluthrin | |
| CN217473307U (en) | Even mixing arrangement is used in chinese-medicinal material processing | |
| CN219128433U (en) | Degerming filter equipment | |
| CN215196378U (en) | Agitating unit of double helix conical mixer | |
| CN208526430U (en) | A kind of novel deployment device of pharmacy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |