CN110074417A - A kind of calcium tartrate agent and preparation method thereof - Google Patents
A kind of calcium tartrate agent and preparation method thereof Download PDFInfo
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- CN110074417A CN110074417A CN201910385634.6A CN201910385634A CN110074417A CN 110074417 A CN110074417 A CN 110074417A CN 201910385634 A CN201910385634 A CN 201910385634A CN 110074417 A CN110074417 A CN 110074417A
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- acid
- calcium
- calcium tartrate
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- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 47
- GUPPESBEIQALOS-UHFFFAOYSA-L calcium tartrate Chemical compound [Ca+2].[O-]C(=O)C(O)C(O)C([O-])=O GUPPESBEIQALOS-UHFFFAOYSA-L 0.000 title claims abstract description 43
- 239000001427 calcium tartrate Substances 0.000 title claims abstract description 43
- 235000011035 calcium tartrate Nutrition 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 32
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002253 acid Substances 0.000 claims abstract description 17
- 235000002906 tartaric acid Nutrition 0.000 claims abstract description 17
- 239000011975 tartaric acid Substances 0.000 claims abstract description 17
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000011724 folic acid Substances 0.000 claims abstract description 16
- 229960000304 folic acid Drugs 0.000 claims abstract description 16
- 235000019152 folic acid Nutrition 0.000 claims abstract description 16
- 235000012054 meals Nutrition 0.000 claims abstract description 12
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 6
- 235000013325 dietary fiber Nutrition 0.000 claims abstract description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 5
- 108090000288 Glycoproteins Proteins 0.000 claims abstract description 5
- 102000003886 Glycoproteins Human genes 0.000 claims abstract description 5
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 5
- 229940088594 vitamin Drugs 0.000 claims abstract description 5
- 229930003231 vitamin Natural products 0.000 claims abstract description 5
- 235000013343 vitamin Nutrition 0.000 claims abstract description 5
- 239000011782 vitamin Substances 0.000 claims abstract description 5
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 22
- 239000011575 calcium Substances 0.000 claims description 22
- 229910052791 calcium Inorganic materials 0.000 claims description 22
- 239000000243 solution Substances 0.000 claims description 20
- 239000007864 aqueous solution Substances 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 19
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 17
- 238000001354 calcination Methods 0.000 claims description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 239000011260 aqueous acid Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 6
- 102100024023 Histone PARylation factor 1 Human genes 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 229930003268 Vitamin C Natural products 0.000 claims description 6
- 108010005335 mannoproteins Proteins 0.000 claims description 6
- 239000011718 vitamin C Substances 0.000 claims description 6
- 235000019154 vitamin C Nutrition 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 239000001509 sodium citrate Substances 0.000 claims description 5
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 5
- 239000007789 gas Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000002518 antifoaming agent Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 150000005846 sugar alcohols Chemical class 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 9
- 229940069978 calcium supplement Drugs 0.000 abstract description 5
- 239000003651 drinking water Substances 0.000 abstract description 2
- 235000020188 drinking water Nutrition 0.000 abstract description 2
- 229960005069 calcium Drugs 0.000 description 21
- 241000699666 Mus <mouse, genus> Species 0.000 description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 8
- AEMOLEFTQBMNLQ-DTEWXJGMSA-N D-Galacturonic acid Natural products O[C@@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-DTEWXJGMSA-N 0.000 description 5
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 5
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 description 5
- 240000006394 Sorghum bicolor Species 0.000 description 4
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- 239000000470 constituent Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000004575 stone Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 2
- 239000001354 calcium citrate Substances 0.000 description 2
- 239000000292 calcium oxide Substances 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 235000013337 tricalcium citrate Nutrition 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- -1 hydrogen Calcium oxide Chemical class 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of calcium tartrate agent and preparation method thereof.Calcium tartrate agent of the invention, is made including following components by weight percentage: conch meal 53.00-76.00%；Citrate 0.52-1.62%；Tartaric acid 14.20-37.20%；Folic acid 5.51-6.62%；Vitamin 0.61-0.68%；Dietary fiber yeast 1.32-2.56%；Soluble glycoprotein 0.60-1.50%；Uronic acid 0.62-2.32%；Auxiliary agent 0-0.01%.Calcium tartrate agent of the invention has high solubility in water, wine, can add in drinking water, wine, can carry out effective calcium-supplement to human body, while having sober-up function.
Description
Technical field
The present invention relates to a kind of calcium tartrate agent and preparation method thereof.
Background technique
Calcium agent is usually based on the biochemical functions of calcium constituent and pharmacotoxicological effect, using calcium salt as main component
A kind of preparation.Calcium agent on the market mainly has three categories at present.The first kind is inorganic calcium, such as: calcium carbonate, calcium phosphate and hydrogen
Calcium oxide, or be a kind of calcium product that shell, bone obtain after acidolysis, it the advantage is that calcium element content height, the disadvantage is that
Solubility is low, absorption is slow；Second class is organic calcium, such as calcium gluconate (unsuitable diabetes patient), calcium lactate, calcium citrate, vinegar
Sour calcium, calcium citrate etc., its advantage is that solubility is high, the disadvantage is that calcium content is low, that is, have that calcium constituent absorptivity is low or content not
The problem of foot, it is difficult to effective calcium-supplement be carried out to human body and effect is single；Third class is amino acid chelated calcium, bioavailability
Height, but it is absorbed and utilized and is restricted by amino acid carrier, equally exists the single problem of effect.
Therefore, it is necessary to develop a kind of calcium agent, with high solubility, effective calcium-supplement can be carried out to human body.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of calcium tartrate agent and preparation method thereof.This
The calcium tartrate agent of invention belongs to organic calcium, has high solubility in water, wine, can add in drinking water, wine, can be right
Human body carries out effective calcium-supplement, while having sober-up function.
The present invention uses following technical scheme.
A kind of calcium tartrate agent, is made including following components by weight percentage:
Preferably, the citrate is sodium citrate.
Preferably, the vitamin is vitamin C.
Preferably, the soluble glycoprotein is Mannoproteins.
Preferably, the uronic acid is one or both of D- glucuronic acid, D- galacturonic acid.
Preferably, the auxiliary agent is defoaming agent.
It is further preferred that defoaming agent is DSA-5.
The preparation method of above-mentioned calcium tartrate agent, which comprises the following steps:
(1) tartaric acid, folic acid, uronic acid are configured to aqueous solution respectively, it is then that aqueous tartaric acid solution, folic acid is water-soluble
Liquid, alditol aqueous acid are uniformly mixed with conch meal, are reacted 12-15 hours, are obtained reaction solution；
(2) reaction solution, dietary fiber yeast, soluble glycoprotein, auxiliary agent are uniformly mixed, then at 40-50 DEG C every
Exhausted air reaction 24-72 hours, obtain product A；
(3) product A is dried at 85-98 DEG C, is then ground to powder, citrate, vitamin is added to get arriving
Calcium tartrate agent.
Preferably, the aqueous tartaric acid solution, folic acid aqueous solution, alditol aqueous acid concentration be 9-11%.
Tartaric acid, folic acid in the present invention belong to organic acid, and after forming aqueous solution, energy and calcium carbonate reaction are generated and corresponded to
Soluble calcium of organic acid；The present invention, as nutritional ingredient, can enhance the resistance of human body using vitamin C；Mannose egg
The white stabilizer that can be used as calcium tartrate when dispersing in water, can keep whole stable system, keep system big in the short time
There is Calcium Tartrate in amount, in addition, animal immunizing power can be improved in Mannoproteins, improves intestinal flora；In the present invention, D-
Glucuronic acid, D- galacturonic acid can promote the antialcoholism function of liver, can act on liver many kinds of substance, have and promote toxin expelling
Effect.
Preferably, the conch meal is prepared by the following method: shell carries out acid soak, then washes, is dry, calcining.
It is further preferred that the acid soak is to impregnate 50-70 minutes in the hydrochloric acid of 0.6-0.8%；The calcining is
Under nitrogen protection, successively carry out 300-400 DEG C of calcining 10-18 minutes, 600-700 DEG C calcining 25-30 minutes, 900-1000 DEG C
Calcining 40-50 minutes.
In the present invention, shell impregnates 50-70 minutes in the hydrochloric acid of 0.6-0.8%, can effectively remove the miscellaneous of shell surface
Matter, while ensuring that calcium constituent will not excessively be lost；In addition, inventor by practice, find later period calcination temperature less than 900 DEG C,
It is excessively slow to will lead to Decomposition of Calcium Carbonate, is easy to reach reaction balance；The excessively high then equipment requirement of temperature is excessively high；Calcination time is less than 50 points
It is larger that clock will lead to partial size, decomposes not exclusively, overlong time then will lead to excessive energy consumption.The present invention passes through successively not
Synthermal lower calcined shell, can be such that the calcium carbonate in shell sufficiently decomposes, and obtained conch meal partial size is smaller.Meanwhile at this
Under calcination condition, to the of less demanding of equipment, and it be avoided that and consume the excessive energy.The present invention selects the calcined shell of shell
Powder, primary raw material are calcium oxide, can be with air CO2Further reaction generates calcium carbonate and organic acid reaction, calcined shellfish
Shell powder is containing there are many human body essential elements.
Beneficial effects of the present invention
(1) calcium tartrate agent main component of the invention is calcium tartrate, separately contains other water-soluble calcium of organic acid, tool
There is high solubility, can be added in water, wine, calcium absorptivity is high, bioavailability is high, with certain anti-oxidant effect
Fruit can carry out effective calcium-supplement to human body；
(2) by the well-designed of formula, each component of calcium tartrate agent of the invention gives full play to synergistic effect, has
Effective antialcoholism action, the effect that front and back of drinking can achieve effective pre- anti-corona wine, relieve the effect of alcohol；
(3) active principle of calcium tartrate agent of the invention is natural material, safe to the human body harmless, can trust food
With.
(4) preparation process that the present invention is used according to the characteristic of component, the effect of component can be given full play to, and prepare work
Skill is simple, equipment requirement is low, at low cost, can be mass-produced.
Detailed description of the invention
Fig. 1 is the experimental result picture of the sober-up function of the calcium tartrate agent of experimental example 1.
Specific embodiment
Below by embodiment, the present invention will be described in detail
Embodiment 1
A kind of calcium tartrate agent, is made including following components by weight percentage:
The preparation method of above-mentioned calcium tartrate agent, comprising the following steps:
(1) tartaric acid, folic acid, D- glucuronic acid, D- galacturonic acid are configured to aqueous solution respectively, tartaric acid is water-soluble
Liquid, folic acid aqueous solution, D- glucuronic acid aqueous solution, D- galacturonic aqueous acid concentration be 10%；Salt of the shell 0.8%
It in acid, impregnates 50 minutes, then washes, is dry, under nitrogen protection, successively carry out 350 DEG C and calcine 10 minutes, 650 DEG C of calcinings
It calcines 40 minutes within 25 minutes, 950 DEG C, obtains conch meal；Then by aqueous tartaric acid solution, folic acid aqueous solution, D- glucuronic acid water
Solution, D- galacturonic aqueous acid are uniformly mixed with conch meal, are reacted 13 hours, are obtained reaction solution；
(2) reaction solution, dietary fiber yeast, Mannoproteins, DSA-5 are uniformly mixed, are then completely cut off at 50 DEG C empty
Solid/liquid/gas reactions 48 hours, obtain product A；
(3) product A is dried at 90 DEG C, is then ground to powder, sodium citrate, vitamin C is added to get wine is arrived
Stone acid calcium agent.
Embodiment 2
A kind of calcium tartrate agent, is made including following components by weight percentage:
The preparation method of above-mentioned calcium tartrate agent, comprising the following steps:
(1) tartaric acid, folic acid, D- glucuronic acid, D- galacturonic acid are configured to aqueous solution respectively, tartaric acid is water-soluble
Liquid, folic acid aqueous solution, D- glucuronic acid aqueous solution, D- galacturonic aqueous acid concentration be 9%；Salt of the shell 0.6%
It in acid, impregnates 70 minutes, then washes, is dry, under nitrogen protection, successively carry out 300 DEG C and calcine 18 minutes, 600 DEG C of calcinings
It calcines 50 minutes within 30 minutes, 900 DEG C, obtains conch meal；Then by aqueous tartaric acid solution, folic acid aqueous solution, D- glucuronic acid water
Solution, D- galacturonic aqueous acid are uniformly mixed with conch meal, are reacted 12 hours, are obtained reaction solution；
(2) reaction solution, dietary fiber yeast, Mannoproteins, DSA-5 are uniformly mixed, are then completely cut off at 40 DEG C empty
Solid/liquid/gas reactions 72 hours, obtain product A；
(3) product A is dried at 85 DEG C, is then ground to powder, sodium citrate, vitamin C is added to get wine is arrived
Stone acid calcium agent.
Embodiment 3
A kind of calcium tartrate agent, is made including following components by weight percentage:
The preparation method of above-mentioned calcium tartrate agent, comprising the following steps:
(1) tartaric acid, folic acid, D- glucuronic acid, D- galacturonic acid are configured to aqueous solution respectively, tartaric acid is water-soluble
Liquid, folic acid aqueous solution, D- glucuronic acid aqueous solution, D- galacturonic aqueous acid concentration be 11%；Salt of the shell 0.8%
It in acid, impregnates 50 minutes, then washes, is dry, under nitrogen protection, successively carry out 400 DEG C and calcine 10 minutes, 700 DEG C of calcinings
It calcines 40 minutes within 25 minutes, 1000 DEG C, obtains conch meal；Then by aqueous tartaric acid solution, folic acid aqueous solution, D- glucuronic acid water
Solution, D- galacturonic aqueous acid are uniformly mixed with conch meal, are reacted 15 hours, are obtained reaction solution；
(2) reaction solution, dietary fiber yeast, Mannoproteins, DSA-5 are uniformly mixed, are then completely cut off at 50 DEG C empty
Solid/liquid/gas reactions 24 hours, obtain product A；
(3) product A is dried at 98 DEG C, is then ground to powder, sodium citrate, vitamin C is added to get wine is arrived
Stone acid calcium agent.
Experimental example 1
Calcium tartrate agent parameter of the invention is tested, the results are shown in Table 1:
Table 1
| Parameter | Numerical value |
| Appearance | White or light yellow powder |
| Calcium content | >=45% |
| PH (aqueous solution) | 10 |
| It is water-soluble | >=3g/100g water |
| Ethyl alcohol is molten | > 1g/100g ethyl alcohol |
As shown in Table 1, calcium tartrate agent calcium content >=45% of the invention, pH value 10 have high water solubility and wine
Dissolubility.
Experimental example 2
Test the sober-up function of calcium tartrate agent of the invention.
Experimental method: taking mouse 100, and half male and half female, weight is close, is randomly divided into 4 groups, and blank group, mould is respectively set
Type group, experimental group 1, experimental group 2.Blank group: feeding 0.2mL physiological saline；Model group: 50% alcohol concentration of feeding 0.2ml
Strong, colourless liquor distilled from sorghum；Experimental group 1: while the calcium tartrate agent of the strong, colourless liquor distilled from sorghum of 50% alcohol concentration of feeding 0.2ml and 0.01g embodiment 1；
Experimental group 2: the calcium tartrate agent of first feeding 0.2mL physiological saline and 0.01g embodiment 1, then 50% alcohol of feeding 0.2ml are dense
The strong, colourless liquor distilled from sorghum of degree.In the present invention, the foundation of drunk model is carried out to mouse using the strong, colourless liquor distilled from sorghum of 50% alcohol concentration.Mouse seeks connections with
Duration is related with the drunk degree of mouse, and drunk degree is deeper, and it is shorter to seek connections with the time；Drunk degree is more shallow, and it is longer to seek connections with the time.
Record treated mouse seeks connections with duration (s) on metal mesh in the different experiments time (min).Experimental result such as table 2, Fig. 1
It is shown:
The sober-up function of the calcium tartrate agent of the invention of table 2 is tested
As shown in Table 2, in the different experiments time, the time of seeking connections with of naive mice is 250s, and the mouse of model group
Seeking connections with the time is respectively less than 20s, shows that drunk model is successfully established, and model group mouse is in deeper drunk degree.Experimental group 1
Mouse seek connections with the time and obviously increased compared with model group mouse, show that calcium tartrate agent of the invention can slow down drunk mouse
Drunk degree has sober-up function.The mouse of experimental group 2 seeks connections with the time and equally obviously increases compared with model group mouse, shows
Calcium tartrate agent of the invention can pre- preventing drunkenness, there is anti-corona wine effect.The above result shows that calcium tartrate agent of the invention
With antialcoholism action, in front and back of drinking, effectively pre- anti-corona wine, the effect relieved the effect of alcohol can achieve.
Claims (10)
1. a kind of calcium tartrate agent, which is characterized in that be made including following components by weight percentage:
2. calcium tartrate agent according to claim 1, which is characterized in that the citrate is sodium citrate.
3. calcium tartrate agent according to claim 1, which is characterized in that the vitamin is vitamin C.
4. calcium tartrate agent according to claim 1, which is characterized in that the soluble glycoprotein is Mannoproteins.
5. calcium tartrate agent according to claim 1, which is characterized in that the uronic acid is D- glucuronic acid, D- gala
One or both of uronic acid.
6. calcium tartrate agent according to claim 1, which is characterized in that the auxiliary agent is defoaming agent.
7. the preparation method of calcium tartrate agent of any of claims 1-6, which comprises the following steps:
(1) tartaric acid, folic acid, uronic acid are configured to aqueous solution respectively, then by aqueous tartaric acid solution, folic acid aqueous solution, sugar
Aldehydic acid aqueous solution is uniformly mixed with conch meal, is reacted 12-15 hours, is obtained reaction solution；
(2) reaction solution, dietary fiber yeast, soluble glycoprotein, auxiliary agent are uniformly mixed, are then completely cut off at 40-50 DEG C empty
Solid/liquid/gas reactions 24-72 hours, obtain product A；
(3) product A is dried at 85-98 DEG C, is then ground to powder, citrate, vitamin is added to get winestone is arrived
Sour calcium agent.
8. the preparation method of calcium tartrate agent according to claim 7, which is characterized in that the aqueous tartaric acid solution, leaf
Aqueous acid, alditol aqueous acid concentration be 9-11%.
9. the preparation method of calcium tartrate agent according to claim 7, which is characterized in that the conch meal passes through with lower section
Method preparation: shell carries out acid soak, then washes, is dry, calcining.
10. the preparation method of calcium tartrate agent according to claim 9, which is characterized in that the acid soak is in 0.6-
It is impregnated 50-70 minutes in 0.8% hydrochloric acid；The calcining is under nitrogen protection, successively to carry out 300-400 DEG C of calcining 10-18
Minute, 600-700 DEG C of calcining 25-30 minutes, 900-1000 DEG C calcining 40-50 minutes.
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Application publication date: 20190802 |