CN110063441A - A kind of compound maltodextrin fructose liquid composition of small-molecular peptides and preparation method thereof - Google Patents
A kind of compound maltodextrin fructose liquid composition of small-molecular peptides and preparation method thereof Download PDFInfo
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- CN110063441A CN110063441A CN201910289733.4A CN201910289733A CN110063441A CN 110063441 A CN110063441 A CN 110063441A CN 201910289733 A CN201910289733 A CN 201910289733A CN 110063441 A CN110063441 A CN 110063441A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/56—Flavouring or bittering agents
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/68—Acidifying substances
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
A kind of compound maltodextrin fructose liquid composition of small-molecular peptides, maltodextrin 75-85, xylitol 3-8, fructose 15-20, zinc gluconate 2-2.5, sodium citrate 1.5-2, potassium citrate 3.5-4, ferrous bisglycinate chelate 1.2-1.6, multi-vitamins 2-2.8, small molecule oligopeptide 6-10, essence for food 0.09-0.12, potassium sorbate 0.1-0.18, PH regulator, purified water.Invention aims at preoperative patient and the isosmoticity protecting gut barrier and specially designing, easily absorbs, the product without slag for supplementing energy, moisture and electrolyte, reduction insulin resistance.
Description
Technical field
The present invention relates to field of beverage more particularly to a kind of oral small-molecular peptides composite fluid composition and its preparation sides
Method.
Background technique
Pre-operative anxiety is the conventional treatment mode of China's operation, is the capacity and acidity in order to reduce gastric content, prevention
Vomiting and accidentally suction during anesthesia, general provision adult patient with operation answer 8~12h of pre-operative anxiety, prohibit drink 4h.But this is traditional
Preparation measures can make patient enter catabolism state too early, be unfavorable for patient's post-operative recovery.It is primarily present following several respects
Disadvantage.
Firstly, preoperative long-time fasting causes insulin resistance, operation consent fasting in 10~12 hours is still current domestic more
The conventional preoperative medication mode of number hospital, the operation such as stomach and intestine is especially true, the reason is that according to traditional idea, operation consent fasting is prohibited
Drink is the capacity and acidity in order to reduce gastric content, makes gastric emptying, since the protecting function of narcosis lower respiratory tract subtracts
It is weak or disappear, gastric content from backwards flowing may be made, in case of accidentally inhale, can cause asphyxia and aspiration pneumonia and jeopardize patients ' lives；
In addition, can also because caused by vomiting visual area pollute.Traditionally, patient is fasted in 1 evening usually before elective surgery, to guarantee
Gastric emptying.And for colonic operation, also require intestinal juice limpid, without solids content, in order to avoid influence surgical field of view and make
At pollution, and another reason for require fasting.Therefore, the pre-operative anxiety time for generally choosing date for operation conventional is up to 12~16
Hour, to reach the thorough emptying of stomach.And the time that Consecutive operation patient waits is longer, fasting time longest can be 21 hours；
The taboo drink time also accordingly increased, up to 12~14 hours.But pre-operative anxiety and taboo drink may bring following problems: (1) causing
Preoperative series ill symptoms；(2) imaged tissue reparation and wound healing；(3) postoperative insulin resistance is aggravated.
For can independently feed the patient of liquid, preoperative oral glucose can mitigate stress reaction, promote insulin secretion, improve
Insulin sensitivity, thus can be reduced postoperative insulin resistance, hyperglycemia, protein loss, weight loss and muscle function by
Damage, and energy keeping tensions down mood, reduce the generation of postoperative nausea and vomiting, and have heart defencive function；For cannot cannot be into
The patient of food can also be achieved the effect that similar with the speed intravenous glucose of 5mg/kg per minute.ESPEN guide pushes away at present
The patient to choose date for operation to majority is recommended, preoperative Oral liquid sugar carries out metabolism preparation, for the patient that cannot be fed, then by quiet
Arteries and veins approach gives glucose load.Other than non-diabetic patients, preoperative glucose load is also suitable type 2 diabetic patient, glucose load
Can before anesthesia 3h be used for diabetes B patient, do not influence the emptying of stomach, will not occur apparent hyperglycemia and accidentally inhale
Risk.
Therefore develop a kind of stabilization, absorb quickly, preparation method is simple, easy to carry and use oral liquid glucose is for art
Preceding patient is particularly important.
Summary of the invention
The technical problem to be solved by the present invention is to overcome that oral drink is unstable, it is slow to absorb, preparation process is cumbersome and not
It is convenient to use and the shortcomings that carry, provide a kind of stabilization, absorb quickly, preparation method is simple, easy to carry and use small point
Sub- compound maltodextrin fructose liquid composition of peptide and preparation method thereof.
In order to solve the above technical problems, the technical scheme is that
A kind of compound maltodextrin fructose liquid composition of small-molecular peptides, the component containing following parts by weight:
Maltodextrin 75-85, xylitol 3-8, fructose 15-20, zinc gluconate 2-2.5, sodium citrate 1.5-2, lemon
Sour potassium 3.5-4, ferrous bisglycinate chelate 1.2-1.6, multi-vitamins 2-2.8, small molecule oligopeptide 6-10, essence for food 0.09-
0.12, potassium sorbate 0.1-0.18, PH regulator, purified water.
Contain the component of following parts by weight as a preferred technical solution:
Maltodextrin 80, xylitol 6, fructose 18, zinc gluconate 2.3, sodium citrate 1.7, potassium citrate 3.7, sweet ammonia
It is sour ferrous iron 1.4, multi-vitamins 2.4, small molecule oligopeptide 8, essence for food 0.1, potassium sorbate 0.14, PH regulator, pure
Change water
The small active peptides are preferably that soybean oligopeptide, maize oligopeptide, Chinese yam are low as a preferred technical solution,
One of poly- peptide, sea cucumber oligopeptide, donkey-hide gelatin oligopeptide and ocean fish oligopeptide or a variety of combinations.
The pH adjusting agent organic acid or inorganic acid, preferably hydrochloric acid, citric acid, lemon as a preferred technical solution,
One of acid, arginine or acetic acid are a variety of, and the pH value for adjusting fructose liquid composition is 4.7~5.0.
As a preferred technical solution, further include flavouring agent or sweetener, the sweetener be Sucralose, acesulfame potassium,
One of saccharin sodium is a variety of.
The essence for food is food water quality essence, food emulsifying essence or food as a preferred technical solution,
Product one of pulpous state essence is a variety of.
It is 10~15 maltodextrin that the maltodextrin, which selects DE value, as a preferred technical solution,.
The multi-vitamins include one in vitamin A, vitamin B complex and vitamin C as a preferred technical solution,
Kind is a variety of.
A kind of preparation method of composition, specific step is as follows as a preferred technical solution:
1) formula ratio supplementary material is weighed, is added and prepares 20% purified water of total amount, stirring and dissolving adjusts pH to 4.7~5.0；
2) constant volume, stirring, the solution that each component is mixed to get are filtered through the millipore filter of 0.2~0.8um；
3) it sterilizes, it is filling through 100~121 DEG C of high pressure sterilizations after finished product packing；
Its osmotic pressure is 280-320mOsm/kg as a preferred technical solution,.
By adopting the above-described technical solution, 1) present invention aims at preoperative patient for supplementing energy, moisture and electrolysis
Matter reduces insulin resistance, the isosmoticity protecting gut barrier and specially designing, easily absorption, the product without slag.
2) present invention can supplement the damage needed for long-time fasting body and when INTESTINAL CLEANSING containing electrolyte such as sodium, potassium
It loses.Clinical discovery, INTESTINAL CLEANSING make patient lose large quantity of moisture and electrolyte, and the electrolyte disturbance for being easiest to occur is hypokalemia
Disease, hyponatremia is also more typical, and out of strength, indolent and listless, the even nervous, symptoms such as perspire occurs in body, and fasting therewith and prohibits water more
These situations are aggravated.
3) heat density of the present invention is 0.5kcal/ml, while having been taken in compared with juicy, and damage when cleaning intestine can be supplemented
Insufficiency of intake caused by water is prohibited in mistake and fasting.
4) product of the present invention is suitable for patients undergoing elective surgery, different from traditional perioperative enteral nutrition preparation, can be in art
Application, plays the role of quick recovery in the preceding short time.The present invention has well solved the postoperative recovery of traditional pre-operative anxiety patient
Problem.It can obviously improve operation insulin resistance, reduce the heteroplasia of protein, save the protein of muscle and internal organ；Moreover, mending
Filling maltodextrin and fructose can also prevent lipolysis from generating ketosis, reduce the incidence of acid poisoning.
5) present invention is effective to postoperative fast quick-recovery, and has no adverse effects during surgery, to be finally transitioned into clinical application
Strong test basis is provided.
6) we have carried out experimental study for safety of the invention and validity.The result shows that this Preoperative nutritional support system
Agent can be emptied completely in 2 hours by stomach, consistent with the effect of operation consent long-time fasting, not will increase reflux and the wind accidentally inhaled
Danger.Since liquid preparation is without slag, digestion absorbs all very completely, will not increase colonic contents.
7) patient poor present invention is particularly suitable for severe malnutrition, body reserve.
Specific embodiment
A kind of compound maltodextrin fructose liquid composition of small-molecular peptides, the component containing following parts by weight:
Maltodextrin 75-85, xylitol 3-8, fructose 15-20, zinc gluconate 2-2.5, sodium citrate 1.5-2, lemon
Sour potassium 3.5-4, ferrous bisglycinate chelate 1.2-1.6, multi-vitamins 2-2.8, small molecule oligopeptide 6-10, essence for food 0.09-
0.12, potassium sorbate 0.1-0.18, PH regulator, purified water.
Contain the component of following parts by weight as a preferred technical solution:
Maltodextrin 80, xylitol 6, fructose 18, zinc gluconate 2.3, sodium citrate 1.7, potassium citrate 3.7, sweet ammonia
It is sour ferrous iron 1.4, multi-vitamins 2.4, small molecule oligopeptide 8, essence for food 0.1, potassium sorbate 0.14, PH regulator, pure
Change water
The small active peptides are preferably that soybean oligopeptide, maize oligopeptide, Chinese yam are low as a preferred technical solution,
One of poly- peptide, sea cucumber oligopeptide, donkey-hide gelatin oligopeptide and ocean fish oligopeptide or a variety of combinations.
The pH adjusting agent organic acid or inorganic acid, preferably hydrochloric acid, citric acid, lemon as a preferred technical solution,
One of acid, arginine or acetic acid are a variety of, and the pH value for adjusting fructose liquid composition is 4.7~5.0.
As a preferred technical solution, further include flavouring agent or sweetener, the sweetener be Sucralose, acesulfame potassium,
One of saccharin sodium is a variety of.
The essence for food is food water quality essence, food emulsifying essence or food as a preferred technical solution,
Product one of pulpous state essence is a variety of.
It is 10~15 maltodextrin that the maltodextrin, which selects DE value, as a preferred technical solution,.
The multi-vitamins include one in vitamin A, vitamin B complex and vitamin C as a preferred technical solution,
Kind is a variety of.
A kind of preparation method of composition, specific step is as follows as a preferred technical solution:
1) formula ratio supplementary material is weighed, is added and prepares 20% purified water of total amount, stirring and dissolving adjusts pH to 4.7~5.0；
2) constant volume, stirring, the solution that each component is mixed to get are filtered through the millipore filter of 0.2~0.8um；
3) it sterilizes, it is filling through 100~121 DEG C of high pressure sterilizations after finished product packing；
Its osmotic pressure is 280-320mOsm/kg as a preferred technical solution,.
Embodiment 1: a kind of compound maltodextrin fructose liquid composition of small-molecular peptides, the component containing following parts by weight:
Maltodextrin 75, xylitol 3, fructose 15, zinc gluconate 2, sodium citrate 1.5, potassium citrate 3.5, glycine
Ferrous 1.2, multi-vitamins 2, small molecule oligopeptide 6, essence for food 0.09, potassium sorbate 0.1, PH regulator, purified water.
A kind of preparation method of composition, specific step is as follows as a preferred technical solution:
1) formula ratio supplementary material is weighed, is added and prepares 20% purified water of total amount, stirring and dissolving adjusts pH to 4.7；
2) constant volume, stirring, the solution that each component is mixed to get are filtered through the millipore filter of 0.2um；
3) it sterilizes, it is filling through 100 DEG C of high pressure sterilizations after finished product packing；
Its osmotic pressure is 300mOsm/kg as a preferred technical solution,.
Embodiment 2: a kind of compound maltodextrin fructose liquid composition of small-molecular peptides, the component containing following parts by weight:
Maltodextrin 80, xylitol 6, fructose 18, zinc gluconate 2.3, sodium citrate 1.7, potassium citrate 3.7, sweet ammonia
It is sour ferrous iron 1.4, multi-vitamins 2.4, small molecule oligopeptide 8, essence for food 0.1, potassium sorbate 0.14, PH regulator, pure
Change water.
A kind of preparation method of composition, specific step is as follows as a preferred technical solution:
1) formula ratio supplementary material is weighed, is added and prepares 20% purified water of total amount, stirring and dissolving adjusts pH to 4.8；
2) constant volume, stirring, the solution that each component is mixed to get are filtered through the millipore filter of 0.5um；
3) it sterilizes, it is filling through 111 DEG C of high pressure sterilizations after finished product packing；
Its osmotic pressure is 300mOsm/kg as a preferred technical solution,.
Embodiment 3: a kind of compound maltodextrin fructose liquid composition of small-molecular peptides, the component containing following parts by weight:
Maltodextrin 85, xylitol 8, fructose 20, zinc gluconate 2.5, sodium citrate 2, potassium citrate 4, glycine are sub-
Iron 1.6, multi-vitamins 2.8, small molecule oligopeptide 10, essence for food 0.12, potassium sorbate 0.18, PH regulator, purifying
Water.
A kind of preparation method of composition, specific step is as follows as a preferred technical solution:
1) formula ratio supplementary material is weighed, is added and prepares 20% purified water of total amount, stirring and dissolving adjusts pH to 5.0；
2) constant volume, stirring, the solution that each component is mixed to get are filtered through the millipore filter of 0.8um；
3) it sterilizes, it is filling through 121 DEG C of high pressure sterilizations after finished product packing；
Its osmotic pressure is 320mOsm/kg as a preferred technical solution,.
Stability test research
Upper this product is carried out Acceleration study research: 1~3 sample of Example is placed under the conditions of being placed in 40 DEG C ± 2 DEG C,
Sampling analysis when placing full 1,2,3, June measures indices by stability protocol requirement, and the testing result filled out with initial 0 is
100% is used as reference, investigates the situation of change of each index, and investigates the safety indexes such as microorganism according to the rules.
It is stable that the above results show that sample of the present invention respectively investigates project in accelerated test 6 months, various sugar and potassium,
Sodium content has no significant change；Microorganism and 5 hydroxymethyl furfural meet regulation.This product has good stability
The above shows and describes the basic principle, main features and advantages of the invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.It is claimed.
Claims (10)
1. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides, it is characterised in that the component containing following parts by weight:
Maltodextrin 75-85, xylitol 3-8, fructose 15-20, zinc gluconate 2-2.5, sodium citrate 1.5-2, potassium citrate
3.5-4, ferrous bisglycinate chelate 1.2-1.6, multi-vitamins 2-2.8, small molecule oligopeptide 6-10, essence for food 0.09-0.12,
Potassium sorbate 0.1-0.18, PH regulator, purified water.
2. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides as described in claim 1, it is characterised in that contain
The component of following parts by weight:
Maltodextrin 80, xylitol 6, fructose 18, zinc gluconate 2.3, sodium citrate 1.7, potassium citrate 3.7, glycine are sub-
Iron 1.4, multi-vitamins 2.4, small molecule oligopeptide 8, essence for food 0.1, potassium sorbate 0.14, PH regulator, purified water.
3. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides as claimed in claim 1 or 2, it is characterised in that:
The small active peptides are preferably soybean oligopeptide, maize oligopeptide, Chinese yam oligopeptide, sea cucumber oligopeptide, donkey-hide gelatin oligopeptide
With one of ocean fish oligopeptide or a variety of combinations.
4. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides as claimed in claim 1 or 2, it is characterised in that:
The pH adjusting agent organic acid or inorganic acid, preferably one of hydrochloric acid, citric acid, citric acid, arginine or acetic acid or more
Kind, the pH value for adjusting fructose liquid composition is 4.7~5.0.
5. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides as claimed in claim 1 or 2, it is characterised in that:
It further include flavouring agent or sweetener, the sweetener is one of Sucralose, acesulfame potassium, saccharin sodium or a variety of.
6. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides as claimed in claim 1 or 2, it is characterised in that:
The essence for food is one of food water quality essence, food emulsifying essence or food pulpous state essence or a variety of.
7. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides as claimed in claim 1 or 2, it is characterised in that:
It is 10~15 maltodextrin that the maltodextrin, which selects DE value,.
8. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides as claimed in claim 1 or 2, it is characterised in that:
The multi-vitamins include one of vitamin A, vitamin B complex and vitamin C or a variety of.
9. a kind of preparation method of the composition as described in any one of claims 1 or 2, it is characterised in that specific step is as follows:
1) formula ratio supplementary material is weighed, is added and prepares 20% purified water of total amount, stirring and dissolving adjusts pH to 4.7~5.0；
2) constant volume, stirring, the solution that each component is mixed to get are filtered through the millipore filter of 0.2~0.8um；
3) it sterilizes, it is filling through 100~121 DEG C of high pressure sterilizations after finished product packing.
10. a kind of compound maltodextrin fructose liquid composition of small-molecular peptides as claimed in claim 9, it is characterised in that: its
Osmotic pressure is 280-320mOsm/kg.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108835616A (en) * | 2018-05-24 | 2018-11-20 | 范师振 | A kind of nutritional supplement for being drunk before patients surgery |
| CN110638048A (en) * | 2019-10-30 | 2020-01-03 | 山东若尧特医食品有限公司 | Electrolyte formula powder and preparation method thereof |
| CN113974167A (en) * | 2021-11-10 | 2022-01-28 | 海而思（郑州）科技有限公司 | Meal replacement food and preparation method thereof |
-
2019
- 2019-04-11 CN CN201910289733.4A patent/CN110063441A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108835616A (en) * | 2018-05-24 | 2018-11-20 | 范师振 | A kind of nutritional supplement for being drunk before patients surgery |
| CN110638048A (en) * | 2019-10-30 | 2020-01-03 | 山东若尧特医食品有限公司 | Electrolyte formula powder and preparation method thereof |
| CN113974167A (en) * | 2021-11-10 | 2022-01-28 | 海而思（郑州）科技有限公司 | Meal replacement food and preparation method thereof |
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Application publication date: 20190730 |