CN110771762A - Functional beverage suitable for diabetic patients and capable of resisting stress reaction before and after operation - Google Patents

Functional beverage suitable for diabetic patients and capable of resisting stress reaction before and after operation Download PDF

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Publication number
CN110771762A
CN110771762A CN201911087704.6A CN201911087704A CN110771762A CN 110771762 A CN110771762 A CN 110771762A CN 201911087704 A CN201911087704 A CN 201911087704A CN 110771762 A CN110771762 A CN 110771762A
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mass
functional beverage
juice
content
blueberry
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李静
陈冬梅
李梦雪
孙妍
霍金海
王伟明
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Heihe First People's Hospital
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Heihe First People's Hospital
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/68—Acidifying substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a functional beverage suitable for diabetics and capable of resisting stress reaction before and after operation, and belongs to the technical field of functional beverages. The functional beverage is prepared by clarifying raw juice of fructus Hippophae to obtain fructus Hippophae clear juice; clarifying the blueberry juice to obtain blueberry clear juice; then compounding the sea buckthorn clear juice, the blueberry clear juice and water, adding D-ascorbic acid after uniformly mixing, adding citric acid and sodium citrate for regulating acid, adding fructose, xylitol and sucralose after regulating acid, then adding potassium sorbate, finally adding casein phosphopeptide and other nutrition enhancers, and uniformly mixing to obtain the functional beverage. The beverage can resist postoperative stress reaction, improve the immunologic function of patients, stimulate insulin sensitivity to reduce postoperative insulin resistance, reduce wound infection, reduce postoperative nausea and vomiting, reduce sedation and lethargy, discharge early, reduce other complications in perioperative period, and is suitable for quick recovery of patients in surgical operations.

Description

Functional beverage suitable for diabetic patients and capable of resisting stress reaction before and after operation
Technical Field
The invention relates to a functional beverage suitable for diabetics and capable of resisting stress reaction before and after operation, and belongs to the technical field of functional beverages.
Background
For a long time, patients and doctors insist on no water for a long time before the operation. The reason why the patient should not eat water before operation is that the patient may have the gastric contents regurgitated and sucked by mistake. The necessity of strictly prohibiting water intake before operation reduces the appearance of potent anesthesia induction medicines along with the improvement of anesthesia technology, the tracheal intubation with the cuff protects the airway, promotes the progress of modern general anesthesia technology, and greatly reduces the reflux and aspiration during general anesthesia induction, intubation or tube drawing. The necessity of long-time water deprivation before operation is lack of basis in gastric emptying physiology, and if the stomach functions normally, water drinking and oral administration of isotonic equilibrium liquid can quickly empty from the stomach.
According to the continuous clinical research, the long-time water deprivation before the operation causes nausea and vomiting, sedation and lethargy after the operation. Preoperative fasting with water deprivation and dehydration not only causes patients to feel uncomfortable and uncomfortable before operation, but also causes nausea, vomiting and sedation/lethargy after operation, and preoperative long-time fasting with water causes insulin resistance. The insulin resistance and the anabolism of insulin on substrates in perioperative stress response are greatly aggravated by fasting and drinking before the operation, and the insulin plays an important role in the healing growth and the immune function of postoperative wounds, so that the insulin sensitivity before the operation is maintained and is important for protecting the normal postoperative immune function of patients and reducing wound infection or systemic infection. Generally, postoperative fasting causes postoperative ketone bodies, which is the reason of postoperative self-consumption, and indirectly indicates that postoperative nutrient supplement is insufficient and self-metabolic consumption occurs. This is extremely detrimental to post-operative physical recovery. And according to clinical tracking experiments, preoperative and postoperative water deprivation can lead to the time for patients to independently exhaust and defecate, thus causing intestinal obstruction.
With the knowledge and continuous exploration of people on postoperative rehabilitation. According to the consensus of the university conference experts of the society of accelerated rehabilitation surgery and perioperative medical science in 2017 of the American Society of Anesthesiologists (ASA) and the latest guide in 2017 and the results and practices of the clinical scientific research of Japan and Europe and America, the main supplement is divided into two ORSs, namely low-concentration carbohydrate (containing glucose 1.35-3.3%), 500mL and is orally taken 2h before operation; (2) carbohydrate (50g added to 400-800 mL water) is orally taken 2h before surgery. Mainly contains carbohydrate, glucose and the like. Although the corresponding energy and nutrition can be supplemented, the performance in stress response against surgery is not outstanding.
The stress response is a non-specific defense reaction which is generated by the body under strong stimulation and is mainly characterized by sympathetic nerve excitation and the enhancement of the function of the hypothalamus, anterior pituitary and adrenal cortex. The mechanism of stress response is not completely understood, but changes in endocrine system and autonomic nervous function are the main causes of enhanced metabolism, decreased immunity and impaired organ function in the stress state of the body. The cells of body tissues are stimulated by various external factors including wound to generate a series of nonspecific defense reactions. If the stimulation is too strong or lasts too long, the excessive reaction will cause the body to enter failure, which is mainly manifested as abnormal oxygen supply/consumption of the cardiac muscle; the visceral organ vasoconstriction causes renal failure and stress gastric ulcer, and the long-time gastrointestinal insufficiency damages the intestinal mucosa barrier, so that bacterial toxin is easy to enter blood, and the visceral organ vasoconstriction is the pathophysiological basis for the occurrence of the multi-visceral organ failure; increased permeability of pulmonary capillaries, increased blood clotting, susceptibility to Acute Respiratory Distress Syndrome (ARDS); a decrease in insulin sensitivity occurs: "stress diabetes" is mainly manifested by hyperglycemia, hyperinsulinemia and high lactic acidemia. Meanwhile, the glucose intake and utilization capacity is reduced, the hyperglycemia state exists continuously, the fat is not completely oxidized, ketone bodies are generated, the ketonuria, the ketoblood, the peripheral pH value is reduced, the respiratory quotient is reduced, and the loss of the urine nitrogen after stress coexists with the increase of the plasma insulin. Symptoms of surgical stress physiological reaction: increased heart rate, increased blood pressure, increased oxygen demand, decreased immunity, increased gastric acid secretion, decreased or increased intestinal motility, uncontrolled sphincter, etc. (2) Psychological reaction symptoms of surgical stress: anxiety and depression.
Because the operation stress physiological reaction has many and complex symptoms, and the single carbohydrate supplement is difficult to solve the problems, the medicine-food homologous traditional Chinese medicine plays an important role in the field of recovery of the operation patients, wherein the 24 hours before and after the operation is the key of the recovery, and the development of a clear fluid functional beverage to meet the clinical requirements of the operation patients is urgently needed, but the development work in the field is not reported at present.
Disclosure of Invention
In order to solve the problem that the postoperative stress reaction of the operation patient occurs, the invention provides a functional beverage which is suitable for the diabetes patient and has the function of resisting the postoperative stress reaction before and after the operation, and the technical scheme is as follows:
the invention aims to provide a functional beverage which is suitable for diabetics and has the function of resisting stress reaction before and after operation, and the functional beverage is prepared by the following method: clarifying the raw juice of seabuckthorn to obtain clear juice of seabuckthorn; clarifying the blueberry juice to obtain blueberry clear juice; then compounding the sea buckthorn clear juice, the blueberry clear juice and water, adding D-ascorbic acid after uniformly mixing, adding citric acid and sodium citrate for regulating acid, adding fructose, xylitol and sucralose after regulating acid, then adding potassium sorbate, finally adding casein phosphopeptide and other nutrition enhancers, and uniformly mixing to obtain the functional beverage; wherein: the total content of the sea-buckthorn clear juice and the blueberry clear juice in the functional beverage is 6-10 percent (mass), the content of D-ascorbic acid is 0.005-0.03 percent (mass), the content of citric acid is 0.1-0.3 percent (mass), the content of sodium citrate is 0.05-0.1 percent (mass), fructose is 4-10 percent (mass), xylitol is 2-6 percent (mass), sucralose is 0.003-0.012 percent (mass), and the content of potassium sorbate is 0.01-0.04 percent (mass) based on 100 percent of the total mass of the functional beverage; the content of casein phosphopeptide in per kilogram of functional beverage is 0.5mg-1.2 mg.
Preferably, the blueberry clear juice and the sea buckthorn clear juice are compounded according to the volume ratio of 7: 3.
Preferably, the total content of the sea-buckthorn clear juice and the blueberry clear juice in the functional beverage is 8% (by mass).
Preferably, the casein phosphopeptide content per kilogram of functional beverage is 1.0 mg.
Preferably, the total content of the sea-buckthorn clear juice and the blueberry clear juice in the functional beverage is 8 percent (mass), the content of the D-ascorbic acid is 0.01 percent (mass), the content of the citric acid is 0.18 percent (mass), the content of the sodium citrate is 0.08 percent (mass), the content of the fructose is 6 percent (mass), the content of the xylitol is 4 percent (mass), the content of the sucralose is 0.008 percent (mass), and the content of the potassium sorbate is 0.02 percent (mass) based on the total mass of the functional beverage being 100 percent; the content of casein phosphopeptide in each kilogram of functional beverage is 1.0 mg.
Preferably, the blueberry juice is clarified into blueberry clear juice by the following method: inactivating enzyme of fructus Hippophae juice at 95 deg.C, filtering, centrifuging, removing upper layer fructus Hippophae oil layer and lower layer precipitate, centrifuging, and clarifying with diatomaceous earth to obtain fructus Hippophae clear juice.
More preferably, the mesh number of the diatomite is 200 meshes.
Preferably, the blueberry juice is clarified into blueberry clear juice by the following method: filtering the blueberry juice, adding pectinase after filtering, performing enzymolysis at 45 deg.C for 2.5h, inactivating enzyme at 90 deg.C for 15min, centrifuging, and collecting supernatant to obtain blueberry clear juice.
More preferably, the pectinase is added according to 0.07% (mass) of the weight of the blueberry juice.
Preferably, the other nutrition enhancer is calcium lactate, zinc lactate, vitamin B3, vitamin B1, vitamin B12, vitamin B6 and taurine, and each kilogram of the functional beverage contains 8g of calcium lactate, 14mg of zinc lactate, 34 mg of vitamin B34 mg, 12 mg of vitamin B12 mg, 121 mg of vitamin B121 ug, 61 mg of vitamin B61 mg and 0.4mg of taurine.
The water in the invention refers to pure water.
The nutrition enhancers have the following functions:
1. VB 1: in vivo, the polysaccharide is involved in the metabolism of saccharides, and plays an important role in maintaining normal nerve conduction of the body and normal activities of the heart and digestive system.
2. VB 6: is a coenzyme of various enzymes such as transaminase, decarboxylase, etc. of the body, and can help the decomposition and utilization of sugar and protein.
3. VB 12: is an indispensable substance for human hematopoiesis and nervous system, and the deficiency can cause megaloblastic anemia and nervous system disorder.
4. Nicotinamide, a coenzyme of many dehydrogenases, is deficient in that it affects the absorption and metabolism of cells to cause pellagra, and is used for supplementing nutrients and treating glossitis, dermatitis, etc.
5. Taurine: taurine has effects of inhibiting platelet aggregation, reducing blood lipid, maintaining normal blood pressure of human body and preventing arteriosclerosis, and has protective effect on myocardial cells and anti-arrhythmia; improving endocrine state, enhancing immunity, improving endocrine system state, regulating body, and relieving fatigue.
6. Calcium gluconate: is one of the calcium nutrition enhancers.
7. Zinc gluconate: is a food nutrient zinc fortifier.
The invention has the beneficial effects that:
the stress reaction before and after the operation is a non-specific defense reaction, such as inflammatory reaction, which is a pathophysiological process inevitably occurring after the operation, the local inflammatory reaction causes the increase of vascular permeability, tissue edema, immune cell infiltration and the like, and releases inflammatory factors and mediators, the inflammatory reaction causes the body temperature of a patient to be increased after the operation, and the content of blood leucocytes and neutrophils is increased; the stress response also includes varying degrees of anxiety, fear, sleep disorders such as insomnia, early awakening, nightmare before and after surgery, mental stress during surgery, and the like. The invention takes big fruit sea buckthorn and wild blueberry as main raw materials, and simultaneously, casein phosphopeptide and other ingredients are added in an auxiliary way to prepare a functional beverage which can be suitable for a surgical operation patient to resist preoperative and postoperative stress reactions so as to help the surgical operation patient to relieve the stress reactions before and after the operation and further help the patient to quickly recover Blood index, urinary ketone, exhaust time, blood glucose level, heart rate, etc.) clinical monitoring findings: the blueberry, the sea buckthorn and the casein phosphopeptide are combined together to play a significant positive role in resisting various indexes of stress reaction, can effectively relieve postoperative inflammatory reaction of patients, such as body temperature rise, blood leukocyte and neutrophil content rise, and can relieve symptoms of anxiety, fear, sleep disorder and mental stress of the patients before and after operation. The beverage is suitable for surgical patients needing quick rehabilitation, is beneficial to the healthy development of medical treatment, widens the field of application of small berries and promotes the economic cooperation of the Chinese and Russian border.
The casein phosphopeptide (CPP) is polypeptide which is prepared by taking cow milk casein as a raw material through a biotechnology and has biological activity, is known as a calcium accelerator and can effectively promote absorption and utilization of divalent mineral nutrients such as calcium, iron, zinc and the like by a human body.
Because the beverage is applied to a special population of operation patients and also to diabetes patients, how to proportion various substances in the research and development process to ensure that the operation patients suffering from diabetes can obtain nutrient substances such as energy, ions, amino acids, vitamins and the like for maintaining the basic metabolism of the organism and can also obtain better effect of reducing postoperative stress response is one of the difficulties to be overcome by the beverage, and the selection and proportion of glycogen of the diabetes patients are more difficult to determine.
Because the beverage of the invention adopts two wild berries (sea buckthorn and blueberry), the peel and the kernel of the two wild berries contain a large amount of tannic acid, so that the beverage has a sour taste, and brings adverse effects on the taste of the beverage, therefore, how to improve the taste of the beverage becomes one of the difficulties of the preparation process of the beverage.
The invention uses big fruit sea-buckthorn, wild blueberry and other small berries as basic raw materials, replaces medicines with pure natural foods, fully exerts the homologous functions of medicine and food of the big fruit sea-buckthorn, wild blueberry and other small berries, takes natural foods to nourish the body, and fills the blank of the domestic beverage taking the natural berries as the main component.
Detailed Description
The present invention will be further described with reference to the following specific examples, but the present invention is not limited to these examples.
Example 1: is suitable for diabetes patients and has the function of resisting stress reaction before and after operation.
The beverage in this example was prepared by the following method: clarifying the raw juice of seabuckthorn to obtain clear juice of seabuckthorn; clarifying the blueberry juice to obtain blueberry clear juice; then compounding the sea buckthorn clear juice, the blueberry clear juice and water, adding D-ascorbic acid after uniformly mixing, adding citric acid and sodium citrate for regulating acid, adding fructose, xylitol and sucralose after regulating acid, then adding potassium sorbate, finally adding casein phosphopeptide and other nutrition enhancers, and uniformly mixing to obtain the functional beverage; wherein: the total content of the sea-buckthorn clear juice and the blueberry clear juice in the functional beverage is 8 percent (mass), the content of the D-ascorbic acid is 0.01 percent (mass), the content of the citric acid is 0.18 percent (mass), the content of the sodium citrate is 0.08 percent (mass), the content of the fructose is 6 percent (mass), the content of the xylitol is 4 percent (mass), the content of the sucralose is 0.008 percent (mass), and the content of the potassium sorbate is 0.02 percent (mass) based on the total mass of the functional beverage being 100 percent; the content of casein phosphopeptide in each kilogram of functional beverage is 1.0 mg; the blueberry clear juice and the sea buckthorn clear juice are compounded according to the volume ratio of 7: 3.
The other nutrition enhancer is calcium lactate, zinc lactate, vitamin B3, vitamin B1, vitamin B12, vitamin B6 and taurine, and each kilogram of the functional beverage contains 8g of calcium lactate, 14mg of zinc lactate, 34 mg of vitamin B34 mg, 12 mg of vitamin B12 mg, 121 ug of vitamin B61 mg and 0.4mg of taurine.
A sea-buckthorn raw juice clarification process comprises the following steps:
inactivating enzyme of fructus Hippophae juice at 95 deg.C for 5min, filtering with 240 mesh silk cloth, centrifuging at 4000r for 15min, removing upper layer fructus Hippophae oil layer and lower layer precipitate, centrifuging, and sieving with 200 mesh diatomaceous earth to clarify to obtain fructus Hippophae clear juice, wherein: 20g of 200-mesh diatomite can pass through 250g of raw sea buckthorn juice, and the diatomite is replaced when the raw sea buckthorn juice passes through at a lower speed.
The blueberry juice clarifying process comprises the following steps:
filtering blueberry juice with 80 mesh silk cloth, adding 0.07% (by weight) of blueberry juice after filtering, performing enzymolysis at 45 deg.C for 2.5h, inactivating enzyme at 90 deg.C for 15min, centrifuging at 4500r/min for 20min, and collecting supernatant to obtain blueberry clear juice.
Example 2 this example differs from example 1 in that: the formula is different, in the embodiment, the total content of the sea-buckthorn clear juice and the blueberry clear juice in the functional beverage is 6 percent (mass), the content of the D-ascorbic acid is 0.005 percent (mass), the content of the citric acid is 0.1 percent (mass), the content of the sodium citrate is 0.05 percent (mass), the content of the fructose is 4 percent (mass), the content of the xylitol is 2 percent (mass), the content of the sucralose is 0.003 (mass), the content of the potassium sorbate is 0.01 percent (mass), and the rest is the same as that in the embodiment 1.
Example 3 this example differs from example 1 in that: the formula is different, in the embodiment, the total content of the sea-buckthorn clear juice and the blueberry clear juice in the functional beverage is 10 percent (mass), the content of the D-ascorbic acid is 0.03 percent (mass), the content of the citric acid is 0.3 percent (mass), the content of the sodium citrate is 0.1 percent (mass), the content of the fructose is 10 percent (mass), the content of the xylitol is 2 to 6 percent (mass), the content of the sucralose is 0.003 to 0.012 percent (mass), the content of the potassium sorbate is 0.04 percent (mass), and the rest is the same as the embodiment 1.
Example 4 this example differs from example 1 in that: the casein phosphopeptide content per kilogram of functional beverage was 0.5mg, the other being the same as in example 1.
Example 5 this example differs from example 1 in that: the casein phosphopeptide content per kg of functional beverage was 1.2mg, and the rest was the same as in example 1.
To illustrate the effects that can be obtained with the beverage of the present invention, the following experiments were performed.
And (3) clinical trials:
1. the selection criteria include that 70 patients are selected for period-selective total hysterectomy, sub-total hysterectomy, hysteromyomectomy and ovarian cyst removal, wherein 35 uterine fibroids, 10 uterine adenomyosis and 25 ovarian cysts are selected, the selected patients are all diagnosed with diabetes, the age is 21-57(41.5 +/-8.5) and the body mass index is (22.1 +/-2.2), the 70 patients are divided into an experimental group and a control group according to a random digital table method, and the difference of the age, the body mass index, the diagnosis, the disease condition, the operation mode, the anesthesia mode, the operation time, the intraoperative blood yield and the like of each group of the patients does not have statistical significance P (more than 0.05) according to a random digital table method, and the exclusion criteria are that ⑴ has an operation contraindication, ⑵ has canceration, ⑶ has serious cardiovascular emptiness, ⑷ has serious organ diseases such as liver and kidney, and ⑸ intestinal and stomach delayed patients are unwilling to cooperate with ⑹ and cannot finish testers.
2. Method of producing a composite material
① before operation, fully declaring and agreeing to the former, before operation unconventional mechanical intestinal tract preparation (100 ml anal plug of enema is given before and after operation for constipation patient);
② in operation, the abdominal operation adopts combined anesthesia of lumbar and dural region, the laparoscopic operation adopts composite general anesthesia of trachea cannula at rest, the temperature of the operating room is maintained at 24-26 deg.C and humidity is 50-60%, the infusion speed in operation is controlled and the fluid infusion amount is limited;
③ after anesthesia and waking for 6 hours after operation, getting out of bed for more than 5 times after 1 day after operation, starting normal activity the next day, and eating normally after defecation, etc. two groups of patients are fasting for 12 hours before operation, liquid is not supplemented with vein before operation, ① contrast group is orally administered with 800ml of purified water 8-12 hours before operation, 200ml of purified water is orally administered for 2 hours, purified water is drunk 4 hours after operation, ② test group is orally administered with 800ml of sea buckthorn blueberry mixture before operation for 8-12 hours respectively, 200ml of sea buckthorn blueberry mixture is orally administered for 2 hours, sea buckthorn blueberry mixture is orally administered for 4 hours after operation (50 ml per hour till eating starts), morning urine ketone body detection is performed on 1 day after operation, morning blood routine and C reaction protein are measured on 1 day, 2 days after operation, body temperature monitoring is performed 2 times per day after operation, a febrile keeps monitoring the body temperature to normal for 2 times per day, and blood sugar is monitored on morning, morning after operation, 2 hours after operation, 1 day after operation, and fasting blood sugar is performed on 2.
SPSS17.0 statistical software was used. The measurement data is compared by analysis of variance or t test, and the count data is compared by X2 test. P <0.05 is statistically significant for the differences.
3. And (3) specification of monitoring indexes:
⑴ body temperature, body temperature 1 morning after operation, fever more than 37.5 ℃, and positive rate of fever in each group were compared.
⑵ routine leukocyte count, compare the increase (difference) of leukocytes before and after the 1 st morning.
⑶ C response-the magnitude of increase (difference) of C response before and after the 1 st morning.
⑷ positive rate of vomiting after surgery.
⑸ postoperative abdominal distension was calculated as a positive rate.
⑹ first exhaust time after surgery.
⑺ time to first defecation after surgery.
⑻ Positive rate of uretonions.
⑼ fasting blood glucose on morning of operation, 2 hours after operation, first day after operation, and 2 days after operation.
Grouping condition:
control group ① pure water group
Experimental group ② Casein + blueberry + Hippophae rhamnoides group (example 1)
4. Results
4.1 postoperative fever: the difference was statistically significant (P <0.05) for 6 cases of postoperative fever in the control group (20%), 1 case of fever in the experimental group (3.3%), and lower than the control group.
4.2 comparing the increase range of the leukocyte and the increase range of the C-reactive protein before and after the operation: the experimental group is obviously lower than the control group, and the difference has statistical significance (P is less than 0.01).
4.3 postoperative nausea and vomiting, abdominal distension positive rate comparison: the difference between the experimental group and the control group is statistically significant (P is less than 0.05).
4.4 the experimental group of postoperative first anus exsufflation and defecation time is obviously earlier than the control group, and the difference has statistical significance (P is less than 0.01).
4.5 comparing the positive rate of the postoperative uretone, the experimental group is obviously less than the control group, and the difference has statistical significance (P is less than 0.01).
TABLE 1 patient taking different oral liquid formulations followed by index monitoring comparison
Figure BDA0002265929360000071
4.6 comparing the blood sugar before and after the operation, the fasting blood sugar before and after the operation of the two groups has no difference, the blood sugar 2 hours after the operation of the experimental group, the fasting blood sugar 1 day after the operation and the fasting blood sugar 2 day after the operation are all lower than those of the control group, and the difference has statistical significance (P is all less than 0.01).
TABLE 2 post-operative blood glucose monitoring results
5. And (4) conclusion:
compared with the group given with pure water, the experimental group given with the sea buckthorn and blueberry energy mixture can obviously reduce postoperative fever, relieve inflammatory reaction, reduce the incidence rate of postoperative nausea, vomiting and abdominal distension, promote the early and early recovery of postoperative intestinal functions of patients, promote postoperative exsufflation and defecation, and obviously relieve the generation of postoperative hunger urine ketone bodies of the patients. In the aspect of stabilizing blood sugar after operation, the sea buckthorn and blueberry energy mixture group can obviously relieve the occurrence of stress hyperglycemia of a diabetic patient after operation, so that the blood sugar level of the diabetic patient can be restored to a normal value as soon as possible after operation. In summary, the sea buckthorn and blueberry energy mixture is suitable for being applied to patients in the perioperative period, relieves inflammatory reaction and stabilizes blood sugar.
Sugar acid ratio experiment
Taking 4g of the total mass of the sea buckthorn clear juice and the blueberry clear juice, adding water until the total mass of the sea buckthorn clear juice, the blueberry clear juice and the water is 50g, respectively adding 0.09g of citric acid and 0.04g of sodium citrate, respectively adding fructose, xylitol and sucralose according to test groups 1-9 in the table 1, and then carrying out taste evaluation, wherein the results are shown in the table 3.
TABLE 3 sugar to acid ratio experiment
Figure BDA0002265929360000082
From the results in table 3, it can be seen that the total mass of the beverage (sea buckthorn clear juice, blueberry clear juice and water) was 50g, wherein: the total mass of the spine clear juice and the blueberry clear juice is 4g, the citric acid is 0.09g, the sodium citrate is 0.04g, the sucralose is 4mg, the xylitol is 2g, and the crystalline fructose is 3g, so that the sour and sweet taste is moderate, and the mouthfeel is good, namely: based on the total mass of the functional beverage being 100%, the total content of the sea-buckthorn clear juice and the blueberry clear juice in the functional beverage is 8% (mass), the content of the citric acid is 0.18% (mass), the content of the sodium citrate is 0.08% (mass), the content of the fructose is 6% (mass), the content of the xylitol is 4% (mass), and the sucralose is 0.008% (mass), so that the functional beverage is moderate in sourness and sweetness and good in taste.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (10)

1. A functional beverage suitable for diabetics with stress reaction before and after operation is characterized in that the functional beverage is prepared by the following method: clarifying the raw juice of seabuckthorn to obtain clear juice of seabuckthorn; clarifying the blueberry juice to obtain blueberry clear juice; then compounding the sea buckthorn clear juice, the blueberry clear juice and water, adding D-ascorbic acid after uniformly mixing, adding citric acid and sodium citrate for regulating acid, adding fructose, xylitol and sucralose after regulating acid, then adding potassium sorbate, finally adding casein phosphopeptide and other nutrition enhancers, and uniformly mixing to obtain the functional beverage; wherein: the total content of the sea-buckthorn clear juice and the blueberry clear juice in the functional beverage is 6-10 percent (mass), the content of D-ascorbic acid is 0.005-0.03 percent (mass), the content of citric acid is 0.1-0.3 percent (mass), the content of sodium citrate is 0.05-0.1 percent (mass), fructose is 4-10 percent (mass), xylitol is 2-6 percent (mass), sucralose is 0.003-0.012 percent (mass), and the content of potassium sorbate is 0.01-0.04 percent (mass) based on 100 percent of the total mass of the functional beverage; the content of casein phosphopeptide in per kilogram of functional beverage is 0.5mg-1.2 mg.
2. The functional beverage as claimed in claim 1, wherein the blueberry juice and the sea buckthorn juice are mixed according to a volume ratio of 7:3, compounding.
3. The functional beverage according to claim 1 or 2, wherein the total content of the clear juice of hippophae rhamnoides and the clear juice of blueberry in the functional beverage is 8% by mass.
4. The functional beverage according to claim 1, wherein the casein phosphopeptide content per kg of the functional beverage is 1.0 mg.
5. The functional beverage according to claim 1, wherein the total content of the clear juice of hippophae rhamnoides and the clear juice of blueberries in the functional beverage is 8% by mass, the content of D-ascorbic acid is 0.01% by mass, the content of citric acid is 0.18% by mass, the content of sodium citrate is 0.08% by mass, the content of fructose is 6% by mass, the content of xylitol is 4% by mass, the content of sucralose is 0.008% by mass, and the content of potassium sorbate is 0.02% by mass, based on 100% by mass of the total functional beverage; the content of casein phosphopeptide in each kilogram of functional beverage is 1.0 mg.
6. The functional beverage as claimed in claim 1, wherein the clarification of the blueberry juice into blueberry juice is achieved by the following steps: inactivating enzyme of fructus Hippophae juice at 95 deg.C, filtering, centrifuging, removing upper layer fructus Hippophae oil layer and lower layer precipitate, centrifuging, and clarifying with diatomaceous earth to obtain fructus Hippophae clear juice.
7. The functional beverage according to claim 6, wherein the diatomaceous earth has a mesh size of 200 mesh.
8. The functional beverage as claimed in claim 1, wherein the clarification of the blueberry juice into blueberry juice is achieved by the following method: filtering the blueberry juice, adding pectinase after filtering, performing enzymolysis at 45 deg.C for 2.5h, inactivating enzyme at 90 deg.C for 15min, centrifuging, and collecting supernatant to obtain blueberry clear juice.
9. The functional beverage according to claim 8, wherein the pectinase is added in an amount of 0.07 mass% based on the weight of the blueberry juice.
10. Functional beverage according to claim 1, characterized in that the other nutritional supplements are calcium lactate, zinc lactate, vitamin B3, vitamin B1, vitamin B12, vitamin B6 and taurine, and each kilogram of functional beverage contains 8g of calcium lactate, 14mg of zinc lactate, 34 mg of vitamin B34 mg, 12 mg of vitamin B12 mg, 121 ug, 61 mg of vitamin B61 mg and 0.4mg of taurine.
CN201911087704.6A 2019-11-08 2019-11-08 Functional beverage suitable for diabetic patients and capable of resisting stress reaction before and after operation Pending CN110771762A (en)

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Application publication date: 20200211