CN110057648B - Device for packaging sample container with film structure and processing method thereof - Google Patents
Device for packaging sample container with film structure and processing method thereof Download PDFInfo
- Publication number
- CN110057648B CN110057648B CN201910230364.1A CN201910230364A CN110057648B CN 110057648 B CN110057648 B CN 110057648B CN 201910230364 A CN201910230364 A CN 201910230364A CN 110057648 B CN110057648 B CN 110057648B
- Authority
- CN
- China
- Prior art keywords
- sample container
- motor
- packaging
- sample
- area
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004806 packaging method and process Methods 0.000 title claims abstract description 33
- 238000003672 processing method Methods 0.000 title claims abstract description 5
- 238000007789 sealing Methods 0.000 claims abstract description 26
- 238000007731 hot pressing Methods 0.000 claims abstract description 25
- 239000012528 membrane Substances 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 10
- 238000003860 storage Methods 0.000 claims description 32
- 238000005192 partition Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 9
- 238000001179 sorption measurement Methods 0.000 claims description 9
- 230000000903 blocking effect Effects 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 230000000717 retained effect Effects 0.000 claims description 3
- 230000002940 repellent Effects 0.000 claims 1
- 239000005871 repellent Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 abstract description 68
- 239000012472 biological sample Substances 0.000 abstract description 14
- 238000012545 processing Methods 0.000 abstract description 7
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 20
- 239000000243 solution Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 238000012858 packaging process Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 206010012434 Dermatitis allergic Diseases 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
Abstract
The invention relates to the field of biological sample processing, in particular to a device for packaging a sample container with a membrane structure and a processing method thereof. The apparatus for packaging a sample container having a film structure comprises: the device comprises a box body, a hot pressing unit, a vacuumizing and filling unit and a sealing unit. The hot pressing unit, the vacuumizing and filling unit and the sealing unit are all positioned in the box body. The invention solves the problems of sealing property, safety, automation degree, cyclic utilization and the like in the process of processing the biological sample.
Description
Technical Field
The invention relates to the field of biological sample processing, in particular to a device for packaging a sample container with a membrane structure and a processing method thereof.
Background
Biological samples are important resources of medical research, pathological tissue and cell samples are common clinical biological samples, mainly come from operations such as clinical operation, biopsy, puncture and the like, and can be used for pathological diagnosis and medical research by preparing slices, smears and extracting biological macromolecules. The quality of a sample, which is the basis of a medical study, determines to a large extent the accuracy and reliability of the study results. With the rapid progress of research means such as genomics, transcriptomics and proteomics, various analysis techniques also put higher demands on the quality of biological samples.
Under normal conditions, oxygen exists in the air, microorganisms in the biological sample can grow and breed when contacting with the oxygen, and the microorganisms can be effectively prevented from contacting with the oxygen through vacuum packaging, so that the breeding of the microorganisms is prevented.
Formalin is an aqueous solution of formaldehyde, and is colorless and transparent in appearance and corrosive. The use of formalin covers a wide range of uses, in which formaldehyde binds to amino groups of proteins to coagulate the proteins, and thus formalin is used as a tissue fixative and a preservative in medical tests. According to many medical reports, allergic reaction, dermatitis or eczema may be caused when human skin is directly contacted with formalin, and particularly, the phenomenon often occurs to people needing to be contacted with formalin for a long time in work, so that the direct contact of the skin needs to be avoided, and the skin needs to be carelessly contacted and quickly washed by clear water. The formaldehyde has strong volatility, strong irritation to eyes and harm to eyes.
The following problems are encountered during the processing of biological samples:
1. the interior of a container for storing the biological sample must be pumped into a vacuum state, so that the biological sample is prevented from being deteriorated due to contact with air;
2. when formalin liquid is added into a container for preserving a biological sample, a person is prevented from directly contacting the container, otherwise, the human body is injured.
3. The container for storing the biological sample can be recycled, so that the pollution and harm to the environment are reduced;
4. the process of biological sample processing can be automated, improving staff's efficiency.
In order to avoid the above problems, a device for processing a biological sample is required.
In the invention, the sample container is made of transparent plastic material, the flexible film is in a strip shape, and the bottle cap is connected with the sample container.
Disclosure of Invention
The invention aims to solve the problems by using a film sealing means and a filling means. The invention achieves the above purpose through the following technical scheme.
A first aspect of the present invention provides an apparatus for packaging a sample container having a film structure, comprising: the device comprises a box body, a hot pressing unit, a vacuumizing and filling unit and a sealing unit;
the storage box includes: a packaging area, a storage area and a partition plate; the storage box is divided into an encapsulation area and an upper area and a lower area of a storage area by the partition board; the packaging area is used for packaging the sample container, and one side of the packaging area is provided with a first box door; the storage area is used for storing a sample container, and one side of the storage area is provided with a second box door;
the hot pressing unit is located in the packaging area and comprises: the device comprises a first air cylinder, a hot pressing sheet, a driving roller, a driven roller and a first motor; the first air cylinder is fixed at the top in the packaging area and drives the hot pressing sheet connected with the first air cylinder to move; the first motor drives the driving roller and drives the driven roller to run together;
the evacuation and filling unit is located the top of baffle, includes: a second motor, an air chamber, an annular frame, a clamp, an electromagnet, a magnet, a vacuum pump, an electromagnetic metering pump and a second air cylinder; the second motor is arranged on the top surface of the partition plate; the air chamber is connected with a second motor; the annular frame is connected with the air chamber through the hollow pipe, a first through hole is formed in the center of the annular frame, and a plurality of adsorption holes are formed in the annular wall surface of the first through hole at equal intervals;
the second air cylinder is positioned on one side of the second motor and is fixed on the top surface of the partition plate;
the clamping is connected with the second cylinder together and comprises: an upper clamping plate and a lower clamping plate; one end of the upper clamping plate is connected with the telescopic end of the second air cylinder, and the other end of the upper clamping plate is provided with a bayonet; the electromagnet is arranged at the bottom of one end, connected with the second air cylinder, of the upper clamping plate; the lower clamping plate and the upper clamping plate are movably connected together, one end of the lower clamping plate is provided with a circular clamping sleeve, the top surface of the circular clamping sleeve is provided with a first circular groove, and the center of the bottom of the first circular groove is provided with a second through hole; the magnet is arranged at one end of the lower clamping plate and is opposite to the electromagnet up and down; the vacuum pump and the electromagnetic metering pump are respectively communicated with the second through hole in the circular cutting sleeve through a three-way valve;
the sealing unit is located above the partition plate, and includes: a cylinder III, a motor III and a rotating sleeve; the cylinder III drives the motor III to move; the motor III drives the rotating sleeve to rotate; a second circular groove is formed in the top surface of the rotary sleeve;
the sample container, comprising: the bottle body, the threaded opening, the filling opening, the annular skirt edge, the valve and the clamping ring; the upper half part of the bottle body is funnel-shaped, the lower half part of the bottle body is cylindrical, and the interior of the bottle body is hollow; the threaded opening is connected with the top of the bottle body; the clamping ring is arranged at the lower end of the threaded opening; the filling port is positioned at the bottom of the bottle body; the annular skirt is arranged at the circular periphery of the filling port; the valve is provided with a plurality of pieces which are positioned in the bottle body, fixed at the communication position between the inside of the bottle body and the threaded opening and used for blocking the threaded opening;
the bottle cap is used for sealing the sample container and is provided with an internal thread;
the flexible membrane is a strip-shaped structure.
In one embodiment, be provided with rotatory mechanism of taking in the storage area, rotatory mechanism of taking includes: upright posts, turntables, check rings and bearings; two ends of the upright post are respectively fixed with the top surface of the storage area and the ground; the turntables and the bearings are in one-to-one correspondence, each bearing is fixed at the center of the turntables, and the turntables and the bearings are integrally sleeved on the upright posts at equal intervals; the retaining ring has a plurality ofly, all sets up on the top surface of carousel, and adjacent retaining ring interval equals.
In one embodiment, the heat stake is circular in shape and conforms in size to the annular skirt.
In one embodiment, the bottom of the hot preforms are provided with a knife edge.
In one embodiment, the body of the sample container is marked with graduation marks.
In one embodiment, a surface of the circular groove contacting with the bottom of the bottle cap is rough.
In one embodiment, a rubber pad is arranged at the bottom of the second circular groove.
In one embodiment, the outer side wall of the bottle cap is provided with grains.
A second aspect of the present invention provides a method for processing a sample container, comprising the steps of:
firstly, a sample is put into a sample container from a filling opening, a first box door of a packaging area is opened, at the moment, an annular frame is positioned above a sealing unit, the sample container is put into the sample container from a first through hole, an annular skirt edge is clamped on the annular frame, and an air chamber generates negative pressure, so that an adsorption hole adsorbs the sample container and keeps stable.
Secondly, the first box door is closed, the second motor is controlled to rotate, and the sample container moves along with the first box door. And when the annular frame runs to the lower part of the flexible film and corresponds to the position of the hot-pressing sheet, the second motor stops. The hot pressing sheet is electrified for preheating, the air cylinder drives the hot pressing sheet to move downwards, the flexible membrane is pressed to be in contact with the annular skirt edge, the flexible membrane and the annular skirt edge are melted into a whole, and the filling opening of the sample container is sealed by the flexible membrane.
Thirdly, the second motor continues to rotate, and the sample container moves to the vacuumizing and filling unit. Then, the second cylinder pushes the clamping clip to move, the bayonet is clamped above the clamping ring, and the electromagnet and the magnet are mutually attracted together under the condition of no power supply. Then, the electromagnet is electrified to generate a magnetic field which repels the magnet, the electromagnet and the magnet are separated from each other, the circular clamping sleeve and the bayonet are driven to lock the threaded opening, and the threaded opening is located in the circular groove I. Then, the three-way valve is controlled to communicate the vacuum pump with the pipe of the sample container, and the sample container is vacuumized. After the operation is finished, the three-way valve is controlled to act to enable the pipeline of the electromagnetic metering pump to be communicated with the sample container, the previous pipeline is closed, the sample container is filled with liquid, and the electromagnetic metering pump can fill the given amount of liquid into the sample container. After filling liquid, the electromagnet is powered off to separate the clamp from the threaded port, and the solution is completely retained in the sample container due to the blocking of the valve.
Fourthly, the motor II rotates reversely, the sample container returns to the position right above the sealing unit, and the final sealing operation is carried out. The bottle cap is placed into the rotary sleeve in advance, then the air cylinder III slowly moves upwards, the motor III rotates simultaneously, the internal thread of the bottle cap and the threaded opening are mutually meshed together, the threaded opening is sealed, and the sample container is in a completely sealed state. Then, the adsorption holes are all closed.
And fifthly, opening a second box door of the storage area, sequentially placing the packaged sample containers on the rotary disc, rotating the rotary disc to take the sample containers if the sample containers are taken, and placing the sample containers in the storage area for standby if the sample containers are temporarily not used.
The invention has the following beneficial effects:
1. the clamp and the threaded opening are locked in the operation process, so that air leakage is avoided during vacuum pumping, and the interior of the sample container is kept in a vacuum state.
2. All the operation processes of the invention are carried out in a closed environment, so that the formalin solution is prevented from contacting with a human body, and the method is safe and reliable.
3. The flexible film is used for sealing, the used flexible film is disposed after the flexible film is used, the sample container can be repeatedly sealed, and the reuse rate of the sample container is improved.
4. The invention realizes automatic operation, reduces labor intensity and improves working efficiency through coordination and cooperation among various devices.
5. The invention adopts transparent plastic material and is provided with scale marks, thereby being convenient for people to observe samples quantitatively and qualitatively.
Drawings
Fig. 1 is an overall view of the present invention.
Fig. 2 is an overall view two of the present invention.
Fig. 3 is a front view of the present invention.
Fig. 4 is a view of the thermal press unit of the present invention.
Fig. 5 is a view of a separator plate of the present invention.
FIG. 6 is a view of the annular frame of the present invention.
FIG. 7 is a view of a clip of the present invention.
Fig. 8 is a view of the sealing unit of the present invention.
FIG. 9 is a view of the rotary take up mechanism of the present invention.
Fig. 10 is a view of a sample container of the present invention.
Fig. 11 is a view of the bottle cap of the present invention.
Fig. 12 is a first view of the packaging process of the present invention.
Fig. 13 is a second view of the packaging process of the present invention.
Fig. 14 is a third view of the packaging process of the present invention.
Fig. 15 is a partial enlarged view of the encapsulation process of the present invention.
Fig. 16 is a view of a packaged sample container of the present invention.
Detailed Description
Preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, so that those embodiments can be easily implemented by those having ordinary skill in the art to which the present invention pertains. However, the present invention may be embodied in many different forms and is not limited to the embodiments described below. In addition, in order to more clearly describe the present invention, components not connected to the present invention will be omitted from the drawings.
Example one
An apparatus for packaging a sample container having a film structure, comprising: the device comprises a box body 1, a hot pressing unit 2, a vacuumizing and filling unit 3 and a sealing unit 4;
as shown in fig. 1, the storage box 1 includes: a packaging area 11, a storage area 12 and a partition plate 13; the partition plate 13 is positioned in the middle of the storage box 1, and divides the storage box 1 into an upper area and a lower area which are respectively corresponding to the packaging area 11 and the storage area 12; the packaging area 11 is used for packaging the sample container 5, and one side of the packaging area is provided with a first box door 111 which can be opened in a rotating mode; the storage area 12 is used for storing the sample container 5, and one side of the storage area is provided with a second box door 121 which can be opened in a rotating mode;
the thermocompression unit 2 is located in the package region 11 and includes: the hot pressing device comprises a first air cylinder 21, a hot pressing sheet 22, a driving roller 23, a driven roller 24 and a first motor 25;
as shown in fig. 4, the cylinder one 21 is fixed on the top in the encapsulation area 11; the hot pressing sheet 22 is arranged together with the telescopic end of the first air cylinder 21; the first motor 25 is fixed on one side wall in the packaging area 11; the driven roller 24 and the driving roller 23 are both positioned below the hot pressing sheet 22, both are arranged on one side wall in the packaging area 11, and the driving roller 23 is connected with the output end of the motor I25;
the flexible film 6 is in a belt shape, and two ends of the flexible film are respectively wound on the driving roller 23 and the driven roller 24;
as shown in fig. 5, the evacuation and filling unit 3 is located above the partition 13, and includes: a second motor 31, an air chamber 32, an annular frame 33, a clamp 34, an electromagnet 35, a magnet 36, a vacuum pump 37, an electromagnetic metering pump 38 and a second air cylinder 39;
as shown in fig. 6, the second motor 31 is arranged on the top surface of the partition plate 13; the air chamber 32 is arranged together with the output end of the second motor 31; the annular frame 33 is in a flat annular shape and is connected with the air chamber 32 through a hollow pipe, a first through hole 331 is formed in the center of the annular frame 33, and a plurality of adsorption holes 332 are formed in the annular wall surface of the first through hole 331 at equal intervals;
as shown in fig. 7, the second air cylinder 39 is positioned at one side of the second motor 31 and fixed on the top surface of the partition plate 13;
the clamp 34 is connected with the second cylinder 39 and comprises: an upper card 341 and a lower card 342; one end of the upper clamping plate 341 is connected with the telescopic end of the second cylinder 39, and the other end of the upper clamping plate is provided with a bayonet 3411; the electromagnet 35 is arranged at the bottom of one end of the upper clamping plate 341 connected with the second air cylinder 39; the lower clamping plate 342 and the upper clamping plate 341 are movably connected together, one end of the lower clamping plate is provided with a circular clamping sleeve 3421, the top surface of the circular clamping sleeve 3421 is provided with a first circular groove 3422, and the center of the bottom of the first circular groove 3422 is provided with a second through hole 3423; the magnet 36 is arranged at one end of the lower clamping plate 342 and is vertically opposite to the electromagnet 35; the vacuum pump 37 and the electromagnetic metering pump 38 are respectively communicated with a second through hole 3423 on the circular cutting sleeve 3421 through a three-way valve;
as shown in fig. 8, the sealing unit 4 is located above the partition plate 13, and includes: a cylinder III 41, a motor III 42 and a rotating sleeve 43; the third cylinder 41 is fixed on the top surface of the partition plate 13; the motor III 42 is connected with the telescopic end of the cylinder III 41; the center of the bottom of the rotating sleeve 43 is connected with the output end of the motor III 42, and a circular groove II 431 is formed in the top surface of the rotating sleeve 43;
as shown in fig. 10, the sample container 5 includes: a bottle body 51, a threaded opening 52, a filling opening 53, an annular skirt 54, a valve 55 and a clamping ring 56; the upper half part of the bottle body 51 is funnel-shaped, the lower half part is cylindrical, and the interior of the bottle body is hollow; the threaded port 52 is connected with the top of the bottle body 51; the collar 56 is arranged at the lower end of the threaded port 52; the filling port 53 is positioned at the bottom of the bottle body 51; the annular skirt 54 is provided at the circular periphery of the filler opening 53; the valve 55 is provided with a plurality of pieces which are positioned inside the bottle body 51, fixed at the communication position between the inside of the bottle body 51 and the threaded opening 52 and used for sealing the threaded opening 52;
as shown in fig. 11, the bottle cap 7 is used for sealing the sample container 5 and is provided with an internal thread 71.
Preferably, as an implementation, as shown in fig. 9, a rotary fetching mechanism 8 is disposed in the storage area 12, and the rotary fetching mechanism 8 includes: the upright column 81, the rotating disc 82, the retainer ring 88 and the bearing 84; the two ends of the upright column 81 are respectively fixed with the top surface and the ground of the storage area 12; the turntables 82 and the bearings 84 are in one-to-one correspondence, each bearing 84 is fixed at the center of the turntables 82, and the turntables 82 and the bearings 84 are integrally sleeved on the upright columns 81 at equal intervals; the retainer rings 88 are arranged on the top surface of the turntable 82, and the distance between the adjacent retainer rings 88 is equal, so that the sample containers 4 are placed neatly and are convenient for people to take.
Preferably, as an alternative, the hot-compressed tablet 22 is circular and has dimensions corresponding to those of the annular skirt 54, with the aim of bringing the flexible membrane 6 into full contact and conforming to the annular skirt 54.
Preferably, as an embodiment, the bottom of the hot-pressed sheet 22 is provided with a knife edge for the purpose of cutting the flexible film 6.
Preferably, as an implementation mode, the body 51 of the sample container 5 is marked with scale marks for adding a certain amount of solution according to the requirement and facilitating the observation.
Preferably, as an implementation mode, the surface of the circular groove two 431 contacting with the bottom of the bottle cap 7 is rough, which aims to increase the static friction between the circular groove two 431 and the bottle cap 7.
Preferably, as an implementation mode, the bottom of the first circular groove 3422 is provided with a rubber pad, which is intended to prevent air leakage when the screw port 52 contacts the circular cutting sleeve 3421.
Preferably, as an implementation mode, the outer side wall of the bottle cap 7 is provided with lines for the purpose of facilitating the unscrewing of the bottle cap 7.
Example two
An apparatus for packaging a sample container having a film structure according to the first embodiment, the method comprises the following steps:
firstly, the sample is put into the sample container 5 from the inlet 53, the first door 111 of the sealing region 11 is opened, the annular frame 33 is located above the sealing unit 4, the sample container 5 is put into the first through hole 331, the annular skirt 54 is clamped on the annular frame 33, the air chamber 32 generates negative pressure, and the adsorption hole 332 adsorbs the sample container 5 and keeps stable, as shown in fig. 12.
Secondly, the first box door 111 is closed, the second motor 31 is controlled to rotate, and the sample container 5 moves along with the first box door. When the annular frame 33 runs under the flexible film 6 and corresponds to the position of the hot-pressing plate 22, the second motor 31 is stopped, as shown in fig. 13. The hot pressing sheet 22 is electrified for preheating, the first air cylinder 21 drives the hot pressing sheet 22 to move downwards, the flexible membrane 6 is pressed to be in contact with the annular skirt 54, the flexible membrane 6 and the annular skirt 54 are melted into a whole, and the filling opening 53 of the sample container 5 is sealed by the flexible membrane 6.
Thirdly, the second motor 31 continues to rotate, and the sample container 5 moves to the vacuum-pumping and filling unit 3, as shown in fig. 14. Then, the second air cylinder 39 pushes the clip 34 to move, the bayonet 3411 is clipped above the collar 56, and the electromagnet 35 and the magnet 36 are mutually attracted under the condition of no power supply. Then, the electromagnet 35 is energized to generate a magnetic field that repels the magnet 36, so that the electromagnet 35 and the magnet 36 are separated from each other, and the circular ferrule 3421 and the bayonet 3411 are driven to lock the screw mouth 52, and the screw mouth 52 is located in the circular first groove 3422, as shown in fig. 15. Subsequently, the three-way valve is controlled to communicate the vacuum pump 37 with the pipe of the sample container 5, and the sample container 5 is evacuated. After the operation is finished, the three-way valve is controlled to act to enable the pipeline of the electromagnetic metering pump 38 to be communicated with the sample container 5, the previous pipeline is closed, the sample container 5 starts to be filled with liquid, and the electromagnetic metering pump 38 can fill a given amount of liquid into the sample container 5. After filling, the electromagnet 35 is de-energized, so that the clip 34 is separated from the threaded mouth 52, and the solution is totally retained in the sample container 5 due to the obstruction of the valve 55.
Fourthly, the second motor 31 rotates reversely, the sample container 5 returns to the position right above the sealing unit 4, and the final sealing operation is carried out. The cap 7 is put into the rotary sleeve 43 in advance, and then the cylinder three 41 is slowly moved up and the motor three 42 is simultaneously rotated, so that the internal thread 71 of the cap 7 and the screw port 52 are engaged with each other to seal the screw port 52, and the sample container 5 is in a completely sealed state, as shown in fig. 16. Then, the adsorption holes 332 are all closed.
And fifthly, opening the second box door 121 of the storage area 12, sequentially placing the packaged sample containers 5 on the rotary disc 82, if the sample containers are taken, rotating the rotary disc 82 to take the sample containers, and if the sample containers are temporarily not used, placing the sample containers 5 in the storage area 12 for standby.
Claims (9)
1. An apparatus for packaging a sample container having a film structure, comprising: the device comprises a storage box (1), a hot pressing unit (2), a vacuumizing and filling unit (3) and a sealing unit (4);
the storage box (1) comprises: a packaging area (11), a storage area (12) and a partition plate (13); the storage box (1) is divided into an upper area and a lower area by the partition board (13), wherein the upper area and the lower area are a packaging area (11) and a storage area (12); the packaging area (11) is used for packaging the sample container (5), and one side of the packaging area is provided with a first box door (111); the storage area (12) is used for storing the sample container (5), and one side of the storage area is provided with a second box door (121);
the method is characterized in that: the hot pressing unit (2) is positioned in the packaging area (11) and comprises: the device comprises a first air cylinder (21), a hot pressing sheet (22), a driving roller (23), a driven roller (24) and a first motor (25); the first cylinder (21) is fixed at the top in the packaging area (11) and drives the hot pressing sheet (22) connected with the first cylinder to move; the first motor (25) drives the driving roller (23) and drives the driven roller (24) to run together;
the vacuum-pumping and filling unit (3) is located above the partition (13) and comprises: a second motor (31), an air chamber (32), an annular frame (33), a clamp (34), an electromagnet (35), a magnet (36), a vacuum pump (37), an electromagnetic metering pump (38) and a second air cylinder (39); the second motor (31) is arranged on the top surface of the partition plate (13); the air chamber (32) is connected with the second motor (31); the annular frame (33) is connected with the air chamber (32) through a hollow pipe, a first through hole (331) is formed in the center of the annular frame (33), and a plurality of adsorption holes (332) are formed in the annular wall surface of the first through hole (331) at equal intervals; the second air cylinder (39) is positioned on one side of the second motor (31) and is fixed on the top surface of the partition plate (13); the clip (34) includes: an upper card (341) and a lower card (342); one end of the upper clamping plate (341) is connected with the telescopic end of the second air cylinder (39), and the other end of the upper clamping plate is provided with a bayonet (3411); the electromagnet (35) is arranged at the bottom of one end, connected with the second air cylinder (39), of the upper clamping plate (341); the lower clamping plate (342) and the upper clamping plate (341) are movably connected together, one end of the lower clamping plate is provided with a circular clamping sleeve (3421), the top surface of the circular clamping sleeve (3421) is provided with a first circular groove (3422), and the center of the bottom of the first circular groove (3422) is provided with a second through hole (3423); the magnet (36) is arranged at one end of the lower clamping plate (342) and is vertically opposite to the electromagnet (35); the vacuum pump (37) and the electromagnetic metering pump (38) are communicated with a second through hole (3423) in the circular cutting sleeve (3421) through a three-way valve respectively;
the sealing unit (4) is located above the partition plate (13) and includes: a third cylinder (41), a third motor (42) and a rotating sleeve (43); the cylinder III (41) drives the motor III (42) to move; the motor III (42) drives the rotating sleeve (43) to rotate; a second circular groove (431) is formed in the top surface of the rotating sleeve (43);
the sample container (5) comprising: the bottle comprises a bottle body (51), a threaded opening (52), a filling opening (53), an annular skirt (54), a valve (55) and a clamping ring (56);
the bottle cap (7) is used for sealing the sample container (5) and is provided with an internal thread (71);
and a belt-shaped flexible film (6) is connected between the driving roller (23) and the driven roller (24).
2. The apparatus of claim 1, wherein the sample container comprises a film structure, and wherein: be provided with rotatory mechanism (8) of taking in storage area (12), rotatory mechanism (8) of taking includes: the device comprises a vertical column (81), a rotating disc (82), a retainer ring (88) and a bearing (84); two ends of the upright column (81) are respectively fixed with the top surface of the storage area (12) and the ground; the turntables (82) and the bearings (84) are in one-to-one correspondence, each bearing (84) is fixed at the center of the turntables (82), and the turntables (82) and the bearings (84) are integrally sleeved on the upright posts (81) at equal intervals; a plurality of check rings (88) are arranged on the top surface of the rotating disc (82), and the adjacent check rings (88) are equally spaced.
3. The apparatus of claim 2, wherein the sample container comprises a film structure, and wherein: the hot preforms (22) are circular and have dimensions corresponding to the annular skirt (54).
4. A device for packaging a sample container having a membrane structure according to claim 3, wherein: the bottom of the hot pressing sheet (22) is provided with a knife edge.
5. The apparatus of claim 4, wherein the sample container comprises a film structure, and wherein: the bottle body (51) of the sample container (5) is marked with scale marks.
6. The apparatus of claim 5, wherein the sample container comprises a film structure, and wherein: the contact surface of the second circular groove (431) and the bottom of the bottle cap (7) is rough.
7. The apparatus of claim 6, wherein the sample container comprises a film structure, and wherein: the bottom of the first circular groove (3422) is provided with a rubber pad.
8. The apparatus of claim 7, wherein the sample container comprises a film structure, and wherein: the outer side wall of the bottle cap (7) is provided with grains.
9. The apparatus for packaging a sample container having a membrane structure according to any one of claims 1 to 8, wherein: the sample container processing method is as follows:
firstly, putting a sample into a sample container (5) from a filling opening (53), opening a first box door (111) of a packaging area (11), positioning an annular frame (33) above a sealing unit (4), putting the sample container (5) into a first through hole (331), clamping an annular skirt (54) on the annular frame (33), and generating negative pressure by an air chamber (32) to enable an adsorption hole (332) to adsorb the sample container (5) and keep the sample container stable;
secondly, closing the first box door (111), and controlling the second motor (31) to rotate, so that the sample container (5) moves together with the first box door; when the annular frame (33) runs to the lower part of the flexible film (6) and corresponds to the position of the hot pressing sheet (22), the second motor (31) stops; the hot pressing sheet (22) is electrified for preheating, the cylinder I (21) drives the hot pressing sheet (22) to move downwards, the flexible membrane (6) is pressed to be in contact with the annular skirt (54), the two are melted into a whole, and then the filling opening (53) of the sample container (5) is sealed by the flexible membrane (6);
thirdly, the second motor (31) continues to rotate, and the sample container (5) moves to the vacuumizing and filling unit (3); then, the second air cylinder (39) pushes the clamp (34) to move, the bayonet (3411) is clamped above the clamping ring (56), and the electromagnet (35) and the magnet (36) are mutually attracted together under the condition of no power supply; then, the electromagnet (35) is electrified to generate a magnetic field which is repellent to the magnet (36), the electromagnet (35) and the magnet (36) are separated from each other, the circular cutting sleeve (3421) and the bayonet (3411) are driven to lock the threaded opening (52), and the threaded opening (52) is positioned in the circular groove I (3422); then, controlling the three-way valve to enable the vacuum pump (37) to be communicated with the pipeline of the sample container (5), and vacuumizing the sample container (5); after the operation is finished, the three-way valve is controlled to act to enable the pipeline of the electromagnetic metering pump (38) to be communicated with the sample container (5), the previous pipeline is closed, the sample container (5) starts to be filled with liquid, and the electromagnetic metering pump (38) can fill a given amount of liquid into the sample container (5); after filling liquid, the electromagnet (35) is powered off, the clamp (34) is separated from the threaded opening (52), and the solution is completely retained in the sample container (5) due to the blocking of the valve (55);
fourthly, the motor II (31) rotates reversely, the sample container (5) returns to the position right above the sealing unit (4), and the final sealing operation is carried out; the bottle cap (7) is put into the rotary sleeve (43) in advance, then the air cylinder III (41) moves up slowly, the motor III (42) rotates simultaneously, the internal thread (71) of the bottle cap (7) and the threaded opening (52) are meshed together, the threaded opening (52) is sealed, and the sample container (5) is in a completely sealed state; then, the adsorption holes (332) are all closed;
and next, opening a second box door (121) of the storage area (12), sequentially placing the packaged sample containers (5) on the rotary disc (82), if the sample containers are taken, rotating the rotary disc (82) to take the sample containers, and if the sample containers are not used temporarily, placing the sample containers (5) in the storage area (12) for standby.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910230364.1A CN110057648B (en) | 2019-03-28 | 2019-03-28 | Device for packaging sample container with film structure and processing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910230364.1A CN110057648B (en) | 2019-03-28 | 2019-03-28 | Device for packaging sample container with film structure and processing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110057648A CN110057648A (en) | 2019-07-26 |
| CN110057648B true CN110057648B (en) | 2021-09-17 |
Family
ID=67315952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910230364.1A Active CN110057648B (en) | 2019-03-28 | 2019-03-28 | Device for packaging sample container with film structure and processing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110057648B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104843620A (en) * | 2015-06-04 | 2015-08-19 | 回音必集团抚州制药有限公司 | Easy-folding bottle oral liquid production system |
| CN106006521A (en) * | 2016-07-13 | 2016-10-12 | 安双志 | Medicinal iodine solution filling production line |
| CN108602574A (en) * | 2015-12-28 | 2018-09-28 | 梅卡多隆自动化有限公司 | The automatic machinery of operation, histology, autopsy and a cytology specimen is safely packed, preserves and transported for medical staff |
| CN208378399U (en) * | 2018-05-17 | 2019-01-15 | 福州美乐莲生物科技有限公司 | Cosmetics cream filling apparatus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1605023A (en) * | 2001-10-19 | 2005-04-06 | 蒙诺根有限公司 | Filtration system and method for obtaining a cytology layer |
-
2019
- 2019-03-28 CN CN201910230364.1A patent/CN110057648B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104843620A (en) * | 2015-06-04 | 2015-08-19 | 回音必集团抚州制药有限公司 | Easy-folding bottle oral liquid production system |
| CN108602574A (en) * | 2015-12-28 | 2018-09-28 | 梅卡多隆自动化有限公司 | The automatic machinery of operation, histology, autopsy and a cytology specimen is safely packed, preserves and transported for medical staff |
| CN106006521A (en) * | 2016-07-13 | 2016-10-12 | 安双志 | Medicinal iodine solution filling production line |
| CN208378399U (en) * | 2018-05-17 | 2019-01-15 | 福州美乐莲生物科技有限公司 | Cosmetics cream filling apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110057648A (en) | 2019-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN205506474U (en) | Be applied to many sampling devices of water sampling unmanned aerial vehicle | |
| AU2014375463B2 (en) | Full-automatic microbial detection and enrichment system and enrichment method thereof | |
| CN206580833U (en) | Micro-biological samples processing system device | |
| ES2654056T3 (en) | Heat sealing apparatus and method for filling and sealing liquid containers | |
| US20220033760A1 (en) | Intelligent Microbial Sample Treatment System | |
| CN109963652B (en) | Extraction system and method for extracting microorganisms contained in a sample | |
| CN106342789B (en) | Cell vitrification freezing treatment equipment and treatment method thereof | |
| CN109731860B (en) | Soft endoscope sterilizing device | |
| CA2934695A1 (en) | Sample preparation unit and sample preparation device | |
| CN110057648B (en) | Device for packaging sample container with film structure and processing method thereof | |
| CN112456420A (en) | Aseptic liquid filling machine of plant extract | |
| CN211056684U (en) | Bovine serum filling equipment | |
| CN209133539U (en) | Lithium ion battery vacuum packaging machine | |
| CN113567428A (en) | High-efficient detection device of heavy metal ion in food | |
| CN112373912A (en) | Case is preserved to extract | |
| CN105910863B (en) | A kind of body fluid enrichment smearing machine | |
| US11028354B2 (en) | Prepared plated media product | |
| CN110074092B (en) | Annular buckle cover vacuumizing sample storage sealing device and method | |
| CN106047661B (en) | PCR detection reagent container and PCR pretreatment system | |
| CN105984644A (en) | Blood sample storage kit and using method thereof | |
| CN211784643U (en) | Device for sealing sample container | |
| US10597694B2 (en) | Sample preparation device and method of preparing a sample for sterility testing | |
| CN205583032U (en) | Liquid machine is annotated in vacuum | |
| CN203833938U (en) | Full-automatic microorganism detection and enrichment system | |
| CN213933025U (en) | Milk powder jar gas tightness detection device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 232068, 5 floor, building 2, Jianghuai cloud mansion, Taikang street, hi tech Zone, Huainan, Anhui Applicant after: Huainan Guandong Information Technology Co.,Ltd. Address before: 232068, 5 floor, building 2, Jianghuai cloud mansion, Taikang street, hi tech Zone, Huainan, Anhui Applicant before: HUAINAN INTELLECTUAL PROPERTY INNOVATION TECHNOLOGY RESEARCH Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230506 Address after: 230088, China (Anhui) Free Trade Pilot Zone, Hefei City, Anhui Province. Room 204, Baten Maker Space, Building E1, Fund Building, Phase II, Innovation Industrial Park, Hefei High tech Zone Patentee after: Hefei Manqian Information Technology Co.,Ltd. Address before: 232068 5th Floor, No. 2 Building, Jianghuaiyun Building, Taikang Street, Huainan High-tech Zone, Anhui Province Patentee before: Huainan Guandong Information Technology Co.,Ltd. |