CN1100543C - Povidone iodine membrane agent - Google Patents
Povidone iodine membrane agent Download PDFInfo
- Publication number
- CN1100543C CN1100543C CN98111921A CN98111921A CN1100543C CN 1100543 C CN1100543 C CN 1100543C CN 98111921 A CN98111921 A CN 98111921A CN 98111921 A CN98111921 A CN 98111921A CN 1100543 C CN1100543 C CN 1100543C
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- CN
- China
- Prior art keywords
- membrane
- povidone iodine
- iodine
- water soluble
- forming material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Abstract
The present invention relates to a sterilization membrane agent containing iodine, which is basically composed of povidone iodine and a water soluble membrane forming material. The proportion by weight of the povidone iodine to the water soluble membrane forming material is from 1:1 to 1:100, and preferably from 1:1 to 1:4. The water soluble membrane forming material comprises polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, etc. The sterilization membrane agent containing iodine forms a membrane by a conventional method. The prepared membrane agent has the advantages of high effective iodine content, rapid sterilization, convenient carrying, small volume and few material consumption.
Description
The invention belongs to the disinfectant technical field that contains iodine, be specifically related to a kind of burn and scald, skin ulcer of being used for the treatment of, gynaecopathia is particularly useful for preventing the membrane that meets the Chinese Pharmacopoeia regulation of spread of sexually transmitted diseases and contraception when sexual intercourse.
Povidone iodine medically has treatment burn and scald, germ-resistant effect.Abroad, EP761.095 and WO97.13520 disclose a kind of povidone iodine water preparation, but it form by povidone iodine and film former, topple over during use or coat film forming on the skin, be used for burn and scald.The shortcoming of this water preparation is to carry inconvenience, and the intravaginal medication has certain difficulty, need be equipped with administrator." Chinese pharmacopoeia has been recorded a kind of povidone iodine suppository, and this shortcoming is that volume is very big, and consumptive material is many, and dissolution velocity is slow, because volume is bigger, and in being used for the treatment of gynaecopathia or contraception, sexual intercourse immediately after the medication.
The objective of the invention is to the above-mentioned shortcoming that exists at prior art, provide a kind of sterilization rapidly, be easy to carry and use, volume is little, the povidone iodine membrane agent that consumptive material is few.
Technical scheme of the present invention is as follows:
The composition of this membrane is made up of povidone iodine and water soluble film-forming material basically, and its ratio (weight) is 1: 1-1: 100; Preferably: 1: 1-1: 4.Wherein water soluble film-forming material is selected from polyvinylpyrrolidone, hydroxypropyl cellulose.
Its preparation method is: respectively water soluble film-forming material and povidone iodine is dissolved in 2-10 part deionized water in proportion, two kinds of solution mixed the back add a small amount of glycerol, and surfactant, mixing is made the membrane that flexibility meets the Chinese Pharmacopoeia regulation by well-established law.
Advantage of the present invention is:
(1) can discharge iodine after the dissolving of this membrane, the active gene of energy oxidation thalline spore slurry, and can make latter's degeneration with protein bound, have effects such as very strong kill bacteria, fungus, spore, virus and protozoon, can be used for treating various gynecological diseases, as cervical erosion, attached road infusorian, vaginitis etc., and has repair function preferably.Because povidone iodine has the intensive sperm effect of killing under low concentration; so can be used for contraception; this membrane in intravaginal dissolving rapidly, the dissolving back can form protecting film on vaginal wall, thus propagation such as preventing property disease such as gonorrhea, syphilis, AIDS, hepatitis B during sexual intercourse.
(2) this product is a patching, carries, easy to use, and volume is little, and consumptive material is few.
(3) this product is a patching, and dissolving is fast, plays a role rapidly.Especially aspect practising contraception and preventing spread of sexually transmitted diseases, can have sexual intercourse immediately after the medication, very convenient; Add nonoxynolum or Menfegol when the system membrane after, contraceptive effect is better.
Embodiment:
Example 1:
Prescription: polyvinyl alcohol 50g
Povidone iodine 25g
Glycerol a little
15% Tween 80 alcoholic solution a little
The about 200ml of deionized water
Polyvinyl alcohol with 85% ethanol liquid soaked overnight, is filtered, and, repeat above-mentioned steps then to remove the impurity in the polyvinyl alcohol with a little 85% alcoholic solution washing.In purified polyvinylpyrrolidone, add entry 100ml, stir slowly to heat down and reach 90 ℃, treat molten entirely, temperature drops to below 60 ℃, povidone iodine is dissolved in is mixed with 20% solution in the 100ml water, add a little glycerol and tween solution again after will two kinds of solution merging, it is even to stir cloud, catch up with most bubble, make membrane according to a conventional method.
Example 2:
Prescription: polyvinyl alcohol 50g
Povidone iodine 17g
Nonoxynolum 5g
Glycerol a little
The about 200ml of deionized water
Operation is with example 1.
Example 3:
Prescription: hydroxypropyl emthylcellulose 50g
Povidone iodine 50g
Glycerol a little
The about 500ml of deionized water
Hydroxypropyl emthylcellulose is placed 250ml water, and in dissolving below 60 ℃, example 1 is seen in subsequent operation.
Example 4:
Prescription: hydroxypropyl emthylcellulose 50g
Povidone iodine 12.5g
Glycerol a little
The about 170ml of deionized water
Preparation method is seen example 1.
Example 5:
Prescription: polyvinyl alcohol 50g
Povidone iodine 0.5g
Glycerol a little
The about 103ml of deionized water
Preparation method is seen example 1.
Claims (2)
1. povidone iodine membrane agent is characterized in that it is made up of povidone iodine and water soluble film-forming material basically, and its part by weight is 1: 1-1: 100, and water soluble film-forming material is selected from polyvinylpyrrolidone, hydroxypropyl cellulose.
2. membrane according to claim 1 is characterized in that the part by weight preferred 1 of its component: 1-1: 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98111921A CN1100543C (en) | 1998-03-27 | 1998-03-27 | Povidone iodine membrane agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98111921A CN1100543C (en) | 1998-03-27 | 1998-03-27 | Povidone iodine membrane agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1192358A CN1192358A (en) | 1998-09-09 |
| CN1100543C true CN1100543C (en) | 2003-02-05 |
Family
ID=5221805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98111921A Expired - Fee Related CN1100543C (en) | 1998-03-27 | 1998-03-27 | Povidone iodine membrane agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1100543C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1108101C (en) * | 1999-07-16 | 2003-05-14 | 崔建平 | Povidone iodine solution of multi-element dispersion medium |
| CN101642467B (en) * | 2008-08-06 | 2014-04-16 | 吴天祥 | Long-acting disinfection paste |
| ITTO20120258A1 (en) * | 2012-03-21 | 2013-09-22 | Fond Istituto Italiano Di Tecnologia | POLYMERIC COMPOSITE MATERIALS WITH ANTIMICROBIAL AND BIODEGRADABLE PROPERTIES AND THEIR USES. |
| CN108836951A (en) * | 2018-06-20 | 2018-11-20 | 中山万汉制药有限公司 | A kind of povidone iodine slow-release medicine-membrane and preparation method thereof |
| CN110559313A (en) * | 2019-09-23 | 2019-12-13 | 天津农学院 | Sodium alginate film-forming substrate milk cow nipple medicated bath liquid and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095925A (en) * | 1993-05-31 | 1994-12-07 | 湖南经纬实业有限公司 | Povidone iodine ointment |
| CN1176787A (en) * | 1996-09-17 | 1998-03-25 | 葫芦岛市渤海制药厂 | Method for producing bait with anti prawn disease function |
-
1998
- 1998-03-27 CN CN98111921A patent/CN1100543C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095925A (en) * | 1993-05-31 | 1994-12-07 | 湖南经纬实业有限公司 | Povidone iodine ointment |
| CN1176787A (en) * | 1996-09-17 | 1998-03-25 | 葫芦岛市渤海制药厂 | Method for producing bait with anti prawn disease function |
Non-Patent Citations (4)
| Title |
|---|
| 《中药药剂学》第一版 1985-12-31 曹春林上海科学技术出版社出版 * |
| 《中药药剂学》第一版 1985-12-31 曹春林上海科学技术出版社出版;西北药学杂志1997,12(1) 1997-02-28 石俊峰聚维酮碘膜剂的制备和应用;中国医院药学杂志1995,15(10) 1995-10-31 张素梅等聚维酮碘滴眼液的制备和应用 * |
| 中国医院药学杂志1995,15(10) 1995-10-31 张素梅等聚维酮碘滴眼液的制备和应用 * |
| 西北药学杂志1997,12(1) 1997-02-28 石俊峰聚维酮碘膜剂的制备和应用 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1192358A (en) | 1998-09-09 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |