CN110049977B - 作为强效和选择性rock抑制剂的内酰胺、环状脲和氨基甲酸酯及三唑酮衍生物 - Google Patents

作为强效和选择性rock抑制剂的内酰胺、环状脲和氨基甲酸酯及三唑酮衍生物 Download PDF

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CN110049977B
CN110049977B CN201780054580.4A CN201780054580A CN110049977B CN 110049977 B CN110049977 B CN 110049977B CN 201780054580 A CN201780054580 A CN 201780054580A CN 110049977 B CN110049977 B CN 110049977B
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phenyl
dihydrophthalazin
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oxo
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CN110049977A (zh
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胡子伦
王彩兰
陈丽芬
P·W·格伦茨
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Bristol Myers Squibb Co
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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CN201780054580.4A 2016-07-07 2017-07-06 作为强效和选择性rock抑制剂的内酰胺、环状脲和氨基甲酸酯及三唑酮衍生物 Active CN110049977B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359341P 2016-07-07 2016-07-07
US62/359,341 2016-07-07
PCT/US2017/040846 WO2018009622A1 (en) 2016-07-07 2017-07-06 Lactam, cyclic urea and carbamate, and triazolone derivatives as potent and selective rock inhibitors

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Publication Number Publication Date
CN110049977A CN110049977A (zh) 2019-07-23
CN110049977B true CN110049977B (zh) 2022-01-18

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US (1) US10730858B2 (cg-RX-API-DMAC10.html)
EP (1) EP3481816B1 (cg-RX-API-DMAC10.html)
JP (2) JP6903731B2 (cg-RX-API-DMAC10.html)
KR (1) KR102473481B1 (cg-RX-API-DMAC10.html)
CN (1) CN110049977B (cg-RX-API-DMAC10.html)
ES (1) ES2814325T3 (cg-RX-API-DMAC10.html)
WO (1) WO2018009622A1 (cg-RX-API-DMAC10.html)

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JP2021152061A (ja) 2021-09-30
CN110049977A (zh) 2019-07-23
US20190300510A1 (en) 2019-10-03
JP2019520402A (ja) 2019-07-18
EP3481816B1 (en) 2020-06-24
JP6903731B2 (ja) 2021-07-14
KR102473481B1 (ko) 2022-12-01
WO2018009622A1 (en) 2018-01-11
KR20190025960A (ko) 2019-03-12
US10730858B2 (en) 2020-08-04
EP3481816A1 (en) 2019-05-15
JP7225317B2 (ja) 2023-02-20
ES2814325T3 (es) 2021-03-26

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