CN110045122A - Novel early cancer diagnosis and treatment nano probe of DNA aptamer-fluorescent silicon nano particle - Google Patents
Novel early cancer diagnosis and treatment nano probe of DNA aptamer-fluorescent silicon nano particle Download PDFInfo
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- CN110045122A CN110045122A CN201910427215.4A CN201910427215A CN110045122A CN 110045122 A CN110045122 A CN 110045122A CN 201910427215 A CN201910427215 A CN 201910427215A CN 110045122 A CN110045122 A CN 110045122A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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Abstract
The invention discloses a novel early cancer diagnosis and treatment nano probe of a DNA aptamer-fluorescent silicon nanoparticle, which comprises a supporting table, wherein an upright post is fixed at the end part of the supporting table, a cantilever is fixed on the side surface of the upright post, a nano probe body loaded on a scanning probe microscope is installed on the cantilever, a slide rail is fixed at the top part of the supporting table, a slide block matched with the slide rail is arranged on the slide rail, a sample vessel is placed at the top part of the slide block, and a stabilizing mechanism is arranged on the slide block and the slide rail; the invention has the beneficial effects that: the problem that the traditional sample vessel is inconvenient to adjust is solved through the designed slide rail and the slide block; the slide block and the slide rail are provided with the stabilizing mechanisms, so that the slide block is firmly fixed after sliding well, and the movement of a sample vessel is prevented when a nano probe is used for detection, so that the detection is more accurate; through set up dustproof mechanism on the brace table, help utilizing the dust cover to cover the probe body to make it reach dirt-proof effect.
Description
Technical field
The invention belongs to nano-probe technical fields, and in particular to a kind of DNA aptamers-fluorescence silicon nano particles it is novel
Early-stage cancer diagnosis and treatment nano-probe.
Background technique
Epoch progress while, the quality of air be worse and worse, various food it is unqualified, in the time in recent years
Face, the personage for obtaining cancer is more and more, is increasingly dependent on nano-probe in terms of its cancer diagnosis and treatment.
Nano-probe is with spicule made of nanometer materials, and to explore the substance of more subtle precision, nanometer is visited
Needle cooperation flying-spot microscope uses, that is to say, that nano-probe is to be loaded under scanning probe microscopy, and play in fact
The auxiliary products of effect.
Nano-probe is controlled using the feedback loop of scanning probe microscopy, is made itself to approach sample and be received away from surface
The position expansion surface sweeping of rice magnitude simultaneously transmits the information of atom and nanometer materials to scanning probe microscopy.
However the novel early-stage cancer diagnosis and treatment nano-probe of existing DNA aptamers-fluorescence silicon nano particles is when in use
Some unreasonable factors are remained, the novel early-stage cancer diagnosis and treatment of existing DNA aptamers-fluorescence silicon nano particles are received
There is the deficiencies of following aspect when in use for rice probe:
1.DNA aptamers-fluorescence silicon nano particles are directly placed in planchet, and planchet adjusts inconvenient；
2. there is deficiencies for dust-proof aspect.
Summary of the invention
The purpose of the present invention is to provide a kind of novel early-stage cancer diagnosis and treatment of DNA aptamers-fluorescence silicon nano particles to receive
Rice probe, is directly placed in planchet with solving DNA aptamers-fluorescence silicon nano particles mentioned above in the background art,
Planchet adjusts inconvenient；Dust-proof aspect be there is a problem that insufficient.
To achieve the above object, the invention provides the following technical scheme: a kind of DNA aptamers-fluorescence silicon nano particles
Novel early-stage cancer diagnosis and treatment nano-probe, including supporting table, the end of the supporting table are fixed with column, the side surface of the column
It is fixed with cantilever, the nano-probe ontology being loaded on scanning probe microscopy, the top of the supporting table are installed on the cantilever
Portion is fixed with sliding rail, and the sliding block to match with sliding rail is provided on the sliding rail, is placed with planchet at the top of the sliding block.
As a preferred technical solution of the invention, it is provided with firm organization on the sliding block and sliding rail, this is firm
Mechanism includes adjusting rod, fixed ring and fixation hole, and the surface of the sliding rail is provided with multiple fixation holes being spaced apart, described solid
Determine the side surface that ring is fixed on sliding block, the perforation passed through for adjusting rod is offered in the fixed ring, and the tail end of adjusting rod can be inserted
Enter in fixation hole.
As a preferred technical solution of the invention, the head end of the adjusting rod is fixed with knob.
As a preferred technical solution of the invention, the front and rear surfaces of the supporting table are symmetrically fixed with fixed block.
As a preferred technical solution of the invention, it is additionally provided with dust-proof mechanism in the supporting table, the dust-proof machine
Structure includes dust cover and recess, and the surface of the dust cover offers recess corresponding with fixed block.
As a preferred technical solution of the invention, the section of the fixed block is rectangle.
Compared with prior art, the beneficial effects of the present invention are:
(1) by the sliding rail and sliding block of design, it is inconvenient to solve the problems, such as that the planchet in tradition is adjusted；
(2) by the way that firm organization is arranged on sliding block and sliding rail, so that being fixed securely, preventing after sliding block slides
When being detected using nano-probe, the movement of planchet, so that detection is more accurate；
(3) by the way that dust-proof mechanism is arranged in supporting table, help to cover probe bodies using dust cover, thus
So that its achieve the effect that it is dust-proof.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is sliding block overlooking structure diagram of the invention；
Fig. 3 is supporting table overlooking structure diagram of the invention；
Fig. 4 is dust cover formal structure schematic diagram of the invention；
In figure: 1, supporting table；2, adjusting rod；3, fixed block；4, sliding block；5, planchet；6, column；7, cantilever；8, dust-proof
Cover；9, nano-probe ontology；10, fixed ring；11, sliding rail；12, knob；13, fixation hole；14, recess.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Please refer to Fig. 1, Fig. 2, Fig. 3 and Fig. 4, the present invention provides a kind of technical solution: a kind of DNA aptamers-fluorescence silicon is received
The novel early-stage cancer diagnosis and treatment nano-probe of rice grain, including supporting table 1, supporting table 1 play the effect of support, supporting table 1
End is fixed with column 6, and the side surface of the column 6 is fixed with cantilever 7, should convenient for making 7 fixation of cantilever by column 6
The nano-probe ontology 9 being loaded on scanning probe microscopy is installed, convenient for DNA aptamers-fluorescence silicon nanometer on cantilever 7
Particle is detected, and the top of supporting table 1 is fixed with sliding rail 11, and the sliding block 4 to match with sliding rail 11 is provided on the sliding rail 11,
The top of the sliding block 4 is placed with planchet 5, in use, planchet 5 is placed on sliding block 4, when needing adjusting sample ware 5, thus
When so that the detection of nano-probe ontology 9 is more portable, user pulls sliding block 4 movable on sliding rail 11, slides into required position.
In the present embodiment, it is preferred that be provided with firm organization on sliding block 4 and sliding rail 11, which includes adjusting rod
2, fixed ring 10 and fixation hole 13, the surface of sliding rail 11 are provided with multiple fixation holes 13 being spaced apart, and fixed ring 10 is fixed on
The side surface of sliding block 4 offers the perforation passed through for adjusting rod 2 in the fixed ring 10, and the tail end of adjusting rod 2 can be inserted into and fix
In hole 13, in use, adjusting rod 2 passes through the perforation of fixed ring 10, and is inserted into sliding rail 11 after sliding block 4 slides well on sliding rail 11
The fixation hole 13 that surface opens up.
In the present embodiment, it is preferred that the head end of adjusting rod 2 is fixed with knob 12, so that rotating adjusting rod 2 by knob 12
It is more convenient.
In the present embodiment, it is preferred that the front and rear surfaces of supporting table 1 are symmetrically fixed with fixed block 3, convenient for passing through fixed block 3
Play the effect of firm support dust cover 8.
In the present embodiment, it is preferred that be additionally provided with dust-proof mechanism in supporting table 1, which includes dust cover 8 and recessed
Mouth 14, the surface of dust cover 8 offer recess 14 corresponding with fixed block 3, and the section of fixed block 3 is rectangle, in use,
Dust cover 8 is picked up, four recesses 14 of dust cover 8 are inserted into four fixed blocks 3, using dust cover 8 to nano-probe sheet
Body 9 is covered so that its achieve the effect that it is dust-proof.
The working principle of the invention and process for using: in use, planchet 5 is placed on sliding block 4, when needing adjusting sample
Ware 5, so that user pulls sliding block 4 movable on sliding rail 11, needed for sliding into when the detection of nano-probe ontology 9 is more portable
Position, adjusting rod 2 pass through the perforation of fixed ring 10, and are inserted into the fixation hole 13 that 11 surface of sliding rail opens up, and sliding block 4 is fixed, receive
Rice probe bodies 9 DNA aptamers-fluorescence silicon nano particles in planchet 5 are detected, thus early to getting up early cancer
Carry out diagnosis and treatment；
After operation, dust cover 8 is picked up, four recesses 14 of dust cover 8 are inserted into four fixed blocks 3, are utilized
Dust cover 8 covers nano-probe ontology 9 so that its achieve the effect that it is dust-proof.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of novel early-stage cancer diagnosis and treatment nano-probe of DNA aptamers-fluorescence silicon nano particles, including supporting table (1), institute
The end for stating supporting table (1) is fixed with column (6), and the side surface of the column (6) is fixed with cantilever (7), installs on the cantilever (7)
There is the nano-probe ontology (9) being loaded on scanning probe microscopy, it is characterised in that: the top of the supporting table (1) is fixed
There are sliding rail (11), the sliding block (4) to match with sliding rail (11) is provided on the sliding rail (11), is placed at the top of the sliding block (4)
Planchet (5).
2. a kind of novel early-stage cancer diagnosis and treatment nanometer of DNA aptamers-fluorescence silicon nano particles according to claim 1 is visited
Needle, it is characterised in that: be provided with firm organization on the sliding block (4) and sliding rail (11), the firm organization include adjusting rod (2),
Fixed ring (10) and fixation hole (13), the surface of the sliding rail (11) is provided with multiple fixation holes (13) being spaced apart, described
Fixed ring (10) is fixed on the side surface of sliding block (4), and the perforation passed through for adjusting rod (2) is offered in the fixed ring (10), and
The tail end of adjusting rod (2) can be inserted into fixation hole (13).
3. a kind of novel early-stage cancer diagnosis and treatment nanometer of DNA aptamers-fluorescence silicon nano particles according to claim 2 is visited
Needle, it is characterised in that: the head end of the adjusting rod (2) is fixed with knob (12).
4. a kind of novel early-stage cancer diagnosis and treatment nanometer of DNA aptamers-fluorescence silicon nano particles according to claim 1 is visited
Needle, it is characterised in that: the front and rear surfaces of the supporting table (1) are symmetrically fixed with fixed block (3).
5. a kind of novel early-stage cancer diagnosis and treatment nanometer of DNA aptamers-fluorescence silicon nano particles according to claim 4 is visited
Needle, it is characterised in that: be additionally provided with dust-proof mechanism on the supporting table (1), which includes dust cover (8) and recess
(14), the surface of the dust cover (8) offers recess (14) corresponding with fixed block (3).
6. a kind of novel early-stage cancer diagnosis and treatment nanometer of DNA aptamers-fluorescence silicon nano particles according to claim 5 is visited
Needle, it is characterised in that: the section of the fixed block (3) is rectangle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910427215.4A CN110045122B (en) | 2019-05-22 | 2019-05-22 | Cancer diagnosis and treatment device with DNA aptamer-fluorescent silicon nanoparticles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910427215.4A CN110045122B (en) | 2019-05-22 | 2019-05-22 | Cancer diagnosis and treatment device with DNA aptamer-fluorescent silicon nanoparticles |
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| Publication Number | Publication Date |
|---|---|
| CN110045122A true CN110045122A (en) | 2019-07-23 |
| CN110045122B CN110045122B (en) | 2022-05-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910427215.4A Active CN110045122B (en) | 2019-05-22 | 2019-05-22 | Cancer diagnosis and treatment device with DNA aptamer-fluorescent silicon nanoparticles |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111679100A (en) * | 2020-07-16 | 2020-09-18 | 上海华力微电子有限公司 | Nano probe testing method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1862308A (en) * | 2006-06-19 | 2006-11-15 | 中国科学院上海光学精密机械研究所 | Modularized scanning probe microscope |
| CN2916659Y (en) * | 2006-06-19 | 2007-06-27 | 中国科学院上海光学精密机械研究所 | Modular scanning probe microscope |
| CN101040346A (en) * | 2004-10-07 | 2007-09-19 | 南比蒂翁有限责任公司 | Device and method for scanning probe microscopy |
| CN102676508A (en) * | 2012-04-20 | 2012-09-19 | 华森新科（苏州）纳米技术有限公司 | Small molecule probe based on nano-gold and aptamer and preparation method of small molecule probe |
-
2019
- 2019-05-22 CN CN201910427215.4A patent/CN110045122B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040346A (en) * | 2004-10-07 | 2007-09-19 | 南比蒂翁有限责任公司 | Device and method for scanning probe microscopy |
| CN1862308A (en) * | 2006-06-19 | 2006-11-15 | 中国科学院上海光学精密机械研究所 | Modularized scanning probe microscope |
| CN2916659Y (en) * | 2006-06-19 | 2007-06-27 | 中国科学院上海光学精密机械研究所 | Modular scanning probe microscope |
| CN102676508A (en) * | 2012-04-20 | 2012-09-19 | 华森新科（苏州）纳米技术有限公司 | Small molecule probe based on nano-gold and aptamer and preparation method of small molecule probe |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111679100A (en) * | 2020-07-16 | 2020-09-18 | 上海华力微电子有限公司 | Nano probe testing method |
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| CN110045122B (en) | 2022-05-13 |
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