CN110038011A - A kind of Ni Lapani composition of medicine and preparation method thereof - Google Patents
A kind of Ni Lapani composition of medicine and preparation method thereof Download PDFInfo
- Publication number
- CN110038011A CN110038011A CN201910190003.9A CN201910190003A CN110038011A CN 110038011 A CN110038011 A CN 110038011A CN 201910190003 A CN201910190003 A CN 201910190003A CN 110038011 A CN110038011 A CN 110038011A
- Authority
- CN
- China
- Prior art keywords
- medicine
- lapani
- parts
- medicinal powder
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of Ni Lapani composition of medicine and preparation method thereof, belong to drug production field, Ni Lapani composition of medicine includes the component of following parts by weight: 5-8 parts of Ni Lapani, 3-5 parts of tea polyphenols, 8-10 parts of glucose, 5-8 parts of aurantiamarin, -4 parts of Catergen, 65-75 parts of filler, 4-5 parts of disintegrating agent；Preparation method is that Ni Lapani, tea polyphenols and partially filled agent are mixed into internal layer medicinal powder, other raw materials are mixed into surface layer medicinal powder, then use direct tablet compressing machine, insert medicinal powder by surface layer medicinal powder-internal layer medicinal powder-surface layer medicinal powder sequence in tabletting die cavity, after direct tablet compressing, tablet is obtained.The antitumaous effect of drug provided by the invention is preferable, and can weaken its adverse reaction；The direct tablet compressing function used in preparation method improves the partial size uniformity and charging uniformity of medicinal powder, can prevent tablet from sticking on pressing plate, and discharge effect optimization, and working efficiency is higher.
Description
Technical field
The present invention relates to drug production field, it is specifically related to a kind of Ni Lapani composition of medicine and preparation method thereof.
Background technique
Ni Lapani (Niraparib) is a kind of oral Poly ADP-ribose polymerase (PARP) inhibitor, mainly for
It is the cancer of BRCA1/2 gene mutation, exploitation is used for oophoroma and breast cancer.Ni Lapani inhibits cell to repair DNA damage
It is multiple, for the cancer cell with BRCA gene mutation, if PARP activity is further suppressed, when these cell divisions
A large amount of DNA damages will be generated, cancer cell death is caused.The chemical name of Ni Lapa is 2- [4- ((3S) -3- piperidyl) benzene
Base] -2H- indazole -7- formamide, it is developed by MSD Corp., after transfer biotech company, U.S. Tesaro, the public affairs
Department announces the three phase clinical datas that Ni Lapani is directed to advanced ovarian cancer, presents extremely good curative effect.
Ni Lapani capsule went through to list in the U.S. in 2017, and manufacturer is salol company, Thailand, the U.S..Ni Lapa
Most common 1 grade or 2 grades of the adverse reaction of Buddhist nun is haematics toxicity, including anaemia, thrombopenia and neutrophil
Reduce disease；Gastrointestinal discomfort, including nausea, apositia, constipation and vomiting；It is tired etc..These adverse reactions limit Ni Lapa
The promotion and application of Buddhist nun's drug, so needing to develop the Ni Lapani anticancer drug that can reduce its adverse reaction.
Summary of the invention
1. technical problems to be solved
The technical problem to be solved in the present invention is that providing a kind of Ni Lapani composition of medicine and preparation method thereof, provide
Drug antitumaous effect it is preferable, and its adverse reaction can be weakened.
2. technical solution
To solve the above problems, the present invention adopts the following technical scheme that:
A kind of Ni Lapani composition of medicine, the component including following parts by weight:
5-8 parts of Ni Lapani；
3-5 parts of tea polyphenols；
8-10 parts of glucose；
5-8 parts of aurantiamarin；
2-4 parts of vitamin C；
65-75 parts of filler；
4-5 parts of disintegrating agent；
Further, the tea polyphenols select Green Tea Polyphenols.The antitumor action of tea polyphenols has obtained domestic foreign minister
Guan researcher's generally acknowledges, research shows that its bulk composition catechin (accounting for tea polyphenols total amount 70%~80%) plays main function
Effect.And green tea vitamin e rich in, wherein catechin is the one kind for the polyphenol that content is more in plant, distinctive blueness
The ingredient in astringent taste road is very strong antioxidant, while green tea can prevent harmful acidic toxins, and there is high anti-oxidation to make
With, can achieve the effect of preventing ovarian cancer, this just with Ni Lapani be applied to oophoroma inhibiting effect be consistent.
Further, the filler is any one or more in pregelatinized starch, lactose and microcrystalline cellulose
Composition.
Further, the disintegrating agent is sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose and cross-linked carboxymethyl fiber
The composition of any one or more in plain sodium.
The present invention also provides the preparation methods of above-mentioned Ni Lapani composition of medicine, include the following steps:
(I) take partially filled agent with Ni Lapani and tea polyphenols are mixed after, crush simultaneously cross 80 meshes, obtain internal layer medicinal powder；
After mixing by glucose, vitamin C, aurantiamarin, disintegrating agent and remaining filler, after crushing and crossing 80 meshes, table is obtained
Layer medicinal powder, and the mass ratio of internal layer medicinal powder and surface layer medicinal powder is 1:5；
(ii) direct tablet compressing machine is used, by surface layer medicinal powder-internal layer medicinal powder-surface layer medicinal powder sequence filling in tabletting die cavity
Medicinal powder, and the mass ratio for the medicinal powder being successively added three times is that 2.5:1:2.5 obtains tablet after direct tablet compressing；
The structure of the direct tablet compressing machine used in above-mentioned steps (ii) are as follows:
Including workbench, rotary shaft, carry medicine seat, into powder mechanism, tablet press mechanism and medicament discharge mechanism；
The rotary shaft passes through at table core, and it includes three be successively uniformly arranged that the workbench, which revolves around it axis,
It is each (described into powder mechanism into being designed with one right above powder station into powder station, a tabletting station and a drug station
It can be set as needed into powder station and into the quantity that powder mechanism is arranged, the application of direct tablet compressing machine of the present invention can be expanded
Range), the tablet press mechanism is set to the surface of tabletting station, and the medicament discharge mechanism is set to the underface of drug station, described
Fan-shaped medicine outlet is offered on workbench at drug station；The rotary shaft is located at the position above workbench along its week
Circle is fixed with carries medicine seat with each station correspondingly, and described rotary shaft one end connects stepper motor, and the load medicine seat is around rotation
The rotation of axis is successively passed through into powder station, tabletting station and drug station, and a rotational angle of the stepper motor is equal to phase
Angle between adjacent two stations；The load medicine seat is in straight-cylindrical tabletting die cavity, the tabletting mould equipped with what is be vertically arranged
The bore of chamber is less than the width of medicine outlet；
It is described to include horizontally disposed fixed plate and sliding right above fixed plate into powder mechanism and be parallel to fixed plate
Filter plate, be fixed with the sealing drum that inner wall is bonded with filter plate side, filter plate side etc. on the fixed plate periphery
Spacing is fixed with sliding block, and the sealing drum inner wall is equipped with the sliding slot moved up and down for sliding block, opens up at the fixed plate center
There is locating slot, the guide rod being vertically arranged is fixed in the locating slot, the guide rod upper end passes through at filter plate center, institute
It states and is arranged with the spring one that both ends are separately connected fixed plate and filter plate on guide rod；It is evenly distributed with filter opening on the filter plate,
Prescribe medicine hole is evenly distributed in the fixed plate, the filter plate bottom surface, which is fixed with, to be aligned and can just be inserted into down one by one with prescribe medicine hole
The hole stick harness in medicine hole, the fixed plate is interior to be equipped with the electromagnet for being located at prescribe medicine hole lower outside, and the hole stick harness is equipped in lower end
The permanent magnet to repel each other with electromagnetism ferromagnetism；Chamber in the sealing drum above filter plate forms drug storage chamber, the filtering
Plate upper surface is uniformly fixed with the blade of blade upward；Under original state, the elastic force of spring one is less than the gravity of filter plate, filtering
Plate is located at the bottom of sliding slot, and stick harness insertion prescribe medicine in hole blocks prescribe medicine hole in hole；
The tablet press mechanism includes the Anchor plate kit moved up and down by Driven by Hydraulic Cylinder, and the Anchor plate kit includes up and down just
Pair top board and lower platen, respectively correspond at the center of the forward surface of the top board and lower platen it is fixed be magnetic it is attracting
Electromagnetic block two and permanent magnets two, it is equidistant around electromagnetic block two and permanent magnets two between the top board bottom surface and pushing plate top surface
Equipped with spring two, the both ends of the spring two are separately connected top board and lower platen；
The medicament discharge mechanism includes connecing medicine-chest immediately below medicine outlet, and the medicine-chest bottom surface that connects is equipped with soft rubber cushion,
The medicine seat bottom that carries is equipped with the opening-closing plate for being used to block tabletting die cavity, and it is hinged that the opening-closing plate corresponds to the rear side in rotation direction
Medicine seat bottom is being carried, and hinged place is equipped with torsional spring, when the opening-closing plate is in close state at present, bottom is attached on workbench
Surface, permanent magnets one are equipped in the opposite side of the hinged side of opening-closing plate, and the bore of the medicine outlet is greater than the mouth of tabletting die cavity
Diameter, the medicine outlet are equipped with one group with the magnetic attracting bar shaped of permanent magnets one forever on workbench two sidewalls in the radial direction
Multiple permanent magnet monomers of magnet, every group of bar permanent magnet are distributed along to recessed camber line, and the permanent magnet monomer at top with go out
Medicine mouth towards tabletting station along the distance between avris not less than opening-closing plate hinged side the distance between side corresponding thereto, every group
The magnetism of multiple permanent magnet monomers of bar permanent magnet is cumulative from top to bottom.
Further, the guide rod upper end is fixed with the limited block that width is greater than guiding shank diameter, the limited block top
Face is tapered surface.Limited block plays position-limiting action to the stroke that moves up of filter plate, and filter plate is prevented to be detached from guide rod.
Further, downwardly projecting fixture block is fixed at the top board bottom center, in the lower platen upper surface
Recessed card slot compatible with fixture block is equipped at the heart, the thickness of the fixture block is equal to the depth of card slot, and the electromagnetic block two is set
In in fixture block, the permanent magnets two are set in the lower platen immediately below card slot.When lower platen is moved upward to and attaches top board,
Fixture block is just caught in card slot, can enhance top board to the promotion stability and uniform force application of lower platen.
Further, the position of lower platen upper surface connecting spring two is equipped with recessed mounting groove, the mounting groove
Depth be equal to the length after spring two is extruded, be fixed with the extension sleeve being vertically arranged, the spring in the mounting groove
Two are sleeved on extension sleeve.After the upward pressing plate of lower platen moves in place, spring two is fully located in mounting groove, at this time upper pressure
Plate lower surface can be attached to completely on lower platen upper surface, can enhance top board to the promotion stability and uniform force application of lower platen
Property, extension sleeve can play guiding role to the telescopic variation of spring two, spring is prevented to be distorted.
Further, the load medicine seat bottom corresponds to is equipped in the position of one place side of permanent magnets and permanent magnets on opening-closing plate
One magnetic attracting micro- permanent magnets, the magnetism of micro- permanent magnets are less than the magnetic of the permanent magnet monomer at the top of every group of bar permanent magnet
Property.When opening and closing plate closing, effect of the permanent magnets one by the magnetic attraction of micro- permanent magnets can ensure that opening-closing plate to tabletting die cavity bottom
The sealing in portion, and then can prevent medicinal powder from revealing.
3. beneficial effect
(1) contain Ni Lapani and tea polyphenols in drug provided by the present invention.The extremely strong removing of tea polyphenols energy is harmful certainly
By base, lipid peroxidation process is blocked, the activity of human enzymes is improved, thus the effect of playing anti-mutation, anticancer；Tea polyphenols
It can inhibit the growth of tumour cell by influencing the cycle progression of tumour cell, tea polyphenols also can induce apoptosis of tumor cells,
Inhibit tumor cell invasion transfer, Telomerase can be inhibited strongly and directly, anti-cancer effect is obvious；Aurantiamarin is to people's lung
Cancer, the carcinoma of the rectum, kidney, human breast cancer cell have obvious inhibiting effect, not only without mutagenicity, but also can antagonism other chemotherapeutics
The mutagenicity of object, can be used for cancer prevention, so as to reinforce the anticancer function of Ni Lapani drug.Tea polyphenols can be drawn with Buddhist nun
Pa Ni cooperation, reinforces the anticancer function of drug.
(2) contain glucose and vitamin C in drug provided by the present invention.Vitamin C has strong reducing property, can be by people
The ferro element of body supplement is reduced into the iron of reduction-state, and human body intestinal canal is made to more easily absorb ferro element, i.e., vitamin C, which has, promotees
The function of absorbing into ferro element, ferro element are the primary raw materials for synthesizing hemoglobin；Glucose can provide thermal energy；Comprehensive aforementioned two
Person can promote hemoglobin regeneration to enrich blood, can weaken and cause after taking Ni Lapani while improving thermal energy, supplementing the nutrients
Make this adverse reaction of anaemia；In human body hemoglobin measure with promoted, then can increase Ni Lapani in conjunction with plasma protein
Amount weaken its toxic reaction, to advantageously reduce adverse reaction so that the Free drug concentration of Ni Lapani reduces
The possibility of generation.Meanwhile can increase mating type drug total amount, drug treating time can be extended, drug is promoted to play one's part to the full,
And it is advantageously implemented stable drug effect.
(3) contain aurantiamarin in drug provided by the present invention.Aurantiamarin, which can improve, ties up life in adrenal gland, spleen and leucocyte
The content of plain C reaches ascorbic effect in reinforcement.In addition, Ni Lapani generally takes before sleeping, can reduce nauseous, tired
Weary equal adverse reactions bring sense of discomfort.And aurantiamarin is the flavone compound for acting on central nervous system, have it is calm,
The effect of hypnosis can accelerate time for falling asleep, extend sleeping time, improve sleep quality, so that it is nauseous, tired to ensure that drug mitigates
The effect of equal adverse reactions bring sense of discomfort.
(4) the direct tablet compressing machine used in preparation method provided by the present invention include workbench, rotary shaft, carry medicine seat,
Into powder mechanism, tablet press mechanism and medicament discharge mechanism, rotary shaft is passed through at table core, and it includes successively equal that workbench, which revolves around it axis,
Three of even setting are equipped with corresponding mechanism, drug into powder station, a tabletting station and a drug station, corresponding station face
Medicine outlet is offered on workbench at station；Its border of rotary shaft upper end edge is fixed with carries medicine with each station correspondingly
Seat, rotary shaft one end connect stepper motor, carry medicine seat and successively pass through around the rotation of rotary shaft into powder station, tabletting station and drug
Station, a rotational angle of stepper motor are equal to the angle between two neighboring station；It carries medicine seat and is equipped with and be vertically arranged
In straight-cylindrical tabletting die cavity.In application, carry medicine seat around rotary shaft rotate a circle during complete medicinal powder charging, tabletting and
The whole process of discharging is able to achieve cycle operation, and multiple linking operations carried between medicine seat are more close, and each station is continuous
Change movement is conducive to improve working efficiency.
(5) direct tablet compressing machine provided by the present invention includes that horizontally disposed fixed plate and sliding are set to admittedly into powder mechanism
Fixed board surface and the filter plate for being parallel to fixed plate, fixed plate and the side seal of filter plate week, filter plate can slide up and down, fixed
Spring one is connected between plate and filter plate；Prescribe medicine hole is evenly distributed in fixed plate, filter plate bottom surface, which is fixed with, to be inserted into
It puts in poison the hole stick harness in hole, the electromagnet for being located at prescribe medicine hole lower outside is equipped in fixed plate, be equipped in the lower end Kong Saizhu and electromagnetism
The permanent magnet that ferromagnetism is repelled each other；Under original state, the elastic force of spring one is less than the gravity of filter plate, and filter plate is located at the bottom of sliding slot
Portion, hole stick harness insertion prescribe medicine block prescribe medicine hole in hole, when blanking, are powered to electromagnet, permanent magnet is by magnetic repulsion, in addition bullet
The elastic force of spring one overcomes the gravity of filter plate, pops up filter plate, until hole stick harness removes prescribe medicine hole, medicinal powder can be simultaneously
It is fallen from all prescribe medicine holes, can ensure the uniform blanking of medicinal powder；Then it is powered off to electromagnet, filter plate can reset, and stop
Medicinal powder blanking.In addition, filter plate upper surface is uniformly fixed with the blade of blade upward, start the moment moved up under in filter plate
The moment at bottom is moved on to, stronger vibrating effect can be all generated, so that the blade on filter plate upper surface is to the biggish medicinal powder of partial size
It is cut, to advantageously ensure that making full use of for medicinal powder is unified with partial size.
(6) tablet press mechanism of direct tablet compressing machine provided by the present invention includes the pressing plate group moved up and down by Driven by Hydraulic Cylinder
Part, Anchor plate kit include the top board and lower platen of upper and lower face, right respectively at the center of the forward surface of top board and lower platen
The electromagnetic block two for being magnetic attracting and permanent magnets two should be fixed, around two He of electromagnetic block between top board bottom surface and pushing plate top surface
Permanent magnets two are equidistantly equipped with spring two.In application, starting hydraulic cylinder is anti-after Driven by Hydraulic Cylinder Anchor plate kit realizes sheeting operation
To movement, top board and lower platen is driven to move upwardly together, in the process, powers off, be allowed to permanent magnets to electromagnetic block two
Two magnetic attractions generated disappear, at this point, the elastic force of spring two and the gravity of lower platen are downward, keep lower platen quick in a flash
It flicks downwards, generates vibrating effect, the tablet being adhered on lower platen can be shaken off, play anti-adhesion effects.In addition, tablet press mechanism
It is smooth to the squeezing action face of medicinal powder, it can prevent trace occur on the tablet extruded.
(7) medicament discharge mechanism of direct tablet compressing machine provided by the present invention includes being set to tabletting mold cavity bottoms and being equipped with to be used to block
The opening-closing plate of tabletting die cavity and bar permanent magnet group set on medicine outlet on the two sidewalls of workbench radial direction, opening-closing plate one
Side is hinged, and hinged place is equipped with torsional spring, equipped with permanent magnets one in the opposite side of the hinged side of opening-closing plate, every group of bar permanent magnet it is more
A permanent magnet monomer is distributed along to recessed camber line, multiple permanent magnet monomers of every group of bar permanent magnet it is magnetic from top to bottom gradually
Increase.When drug, the permanent magnet monomer at the top of every group of bar permanent magnet first generates magnetic attraction to permanent magnets one, so that opening-closing plate produces
The raw trend rotated down around its hinged side, along with magnetic cumulative multiple permanent magnet monomers successively generate magnetic to permanent magnets one
Suction, at this point, tablet just can be fallen from tabletting die cavity lower port, falls into and connects in medicine-chest so that opening-closing plate gradually fully opens,
Realize drug.The free-falling of tablet is utilized during drug, is conducive to the integrality for ensureing tablet；And the operation of its drug is not
Medicinal powder charging and sheeting operation are influenced, their station is also not take up, may advantageously facilitate working efficiency.
To sum up, the antitumaous effect of drug provided by the present invention is preferable, moreover it is possible to weaken its adverse reaction；It is adopted in preparation method
Direct tablet compressing function improves the partial size uniformity and charging uniformity of medicinal powder, can prevent tablet from sticking on pressing plate, discharge
Effect optimization, working efficiency are higher.
Detailed description of the invention
Fig. 1 is the structural representation front view of direct tablet compressing machine of the invention；
Fig. 2 is the structural representation top view of direct tablet compressing machine of the invention, is not shown in the figure and carries medicine seat 3；
Fig. 3 is the top view for carrying medicine seat 3 and workbench 1；
Fig. 4 is the structural schematic diagram of Section A-A in Fig. 3；
Fig. 5 is the structural representation front view into powder mechanism 4, wherein figure (a) indicates to be in showing for original state into powder mechanism 4
It is intended to, figure (b) indicates the schematic diagram in the open state into powder mechanism 4；
Fig. 6 is the structural representation top view into powder mechanism 4, wherein figure (a) indicates the schematic diagram of fixed plate 41, schemes (b) table
Show the schematic diagram of filter plate 42；
Fig. 7 is the structural schematic diagram of tablet press mechanism 5, wherein figure (a) indicates that tablet press mechanism 5 is in the signal of original state
Figure, figure (b) indicate the schematic diagram in operating status of tablet press mechanism 5；
Fig. 8 is the schematic diagram of opening-closing plate 62；Wherein figure (a) indicates the schematic diagram that opening-closing plate 62 is in close state, and schemes (b)
Indicate the schematic diagram in the open state of opening-closing plate 62；
Appended drawing reference: 1- workbench, 11- medicine outlet, 2- rotary shaft, 3- carry medicine seat, 31- tabletting die cavity, 4- into powder mechanism,
40- blade, 41- fixed plate, 42- filter plate, 43- sealing drum, 44- sliding block, 45- sliding slot, 46- guide rod, 47- spring one, 48-
Prescribe medicine hole, the hole 49- stick harness, 5- tablet press mechanism, 50- hydraulic cylinder, 51- top board, 52- lower platen, 53- electromagnetic block two, 54- permanent magnetism
Block two, 55- spring two, 56- fixture block, 57- card slot, 58- mounting groove, 59- extension sleeve, 6- medicament discharge mechanism, 60- meet medicine-chest, 61-
Soft rubber cushion, 62- opening-closing plate, 63- permanent magnets one, 64- bar permanent magnet, the micro- permanent magnets of 65-, 7- stepper motor, 8- electromagnet, 9-
Permanent magnet, 10- limited block.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.
Embodiment 1
A kind of Ni Lapani composition of medicine, the component including following parts by weight:
5 parts of Ni Lapani；
5 parts of tea polyphenols；
8 parts of glucose；
8 parts of aurantiamarin；
2 parts of vitamin C；
75 parts of filler；
5 parts of disintegrating agent.
In the present embodiment, the filler is microcrystalline cellulose.
In the present embodiment, the disintegrating agent is the combination of low-substituted hydroxypropyl cellulose and croscarmellose sodium
Object, their mass ratio are 1:1.
The preparation method of above-mentioned Ni Lapani composition of medicine, includes the following steps:
(I) take 8 parts of fillers with Ni Lapani and tea polyphenols are mixed after, crush simultaneously cross 80 meshes, obtain internal layer medicinal powder；It will
Glucose, vitamin C, aurantiamarin, disintegrating agent and remaining filler after mixing, after crushing and crossing 80 meshes, obtain surface layer
Medicinal powder；
(ii) direct tablet compressing machine is used, by surface layer medicinal powder-internal layer medicinal powder-surface layer medicinal powder sequence filling in tabletting die cavity
Medicinal powder, and the mass ratio for the medicinal powder being successively added three times is that 2.5:1:2.5 obtains tablet after direct tablet compressing；
The structure of the direct tablet compressing machine used in above-mentioned steps (ii) are as follows:
Including workbench 1, rotary shaft 2, medicine seat 3 is carried, into powder mechanism 4, tablet press mechanism 5 and medicament discharge mechanism 6, such as Fig. 1 and Fig. 2
It is shown；
As shown in Figures 3 and 4, the rotary shaft 2 passes through at 1 center of workbench, and the workbench 1 revolves around it the packet of axis 2
Three be successively uniformly arranged are included into powder station, a tabletting station and a drug station, each into powder station surface
Equipped with one into powder mechanism 4, the tablet press mechanism 5 is set to the surface of tabletting station, and the medicament discharge mechanism 6 is set to drug station
Underface, offer fan-shaped medicine outlet 11 on the workbench 1 at the drug station；The rotary shaft 2 is located at work
The position of 1 top of platform is fixed with along its border carries medicine seat 3 with each station correspondingly, and described 2 one end of rotary shaft connects stepping
Motor 7, the load medicine seat 3 successively pass through around the rotation of rotary shaft 2 into powder station, tabletting station and drug station, the stepping
Rotational angle of motor 7 is equal to the angle between two neighboring station；The load medicine seat 3 is in straight equipped with what is be vertically arranged
The tabletting die cavity 31 of tubular, the bore of the tabletting die cavity 31 are less than the width of medicine outlet 11；
As shown in Figures 5 and 6, described to be set to fixed plate 41 including horizontally disposed fixed plate 41 and sliding into powder mechanism 4
Surface and the filter plate 42 for being parallel to fixed plate 41, inner wall is fixed on 41 periphery of the fixed plate and 42 side of filter plate is pasted
The sealing drum 43 of conjunction, 42 side of filter plate are equidistantly fixed with sliding block 44, and 43 inner wall of sealing drum is equipped with for sliding block
44 sliding slots 45 moved up and down offer locating slot at 41 center of fixed plate, are fixed with and are vertically arranged in the locating slot
Guide rod 46,46 upper end of guide rod pass through 42 center of filter plate at, be arranged with both ends on the guide rod 46 and connect respectively
Connect the spring 1 of fixed plate 41 and filter plate 42；It is evenly distributed with filter opening on the filter plate 42, in the fixed plate 41 uniformly
It is furnished with prescribe medicine hole 48,42 bottom surface of filter plate, which is fixed with, to be aligned one by one with prescribe medicine hole 48 and can just be inserted into the hole in prescribe medicine hole 48
Stick harness 49, the fixed plate 41 is interior to be equipped with the electromagnet 8 for being located at prescribe medicine 48 lower outside of hole, is equipped in 49 lower end of hole stick harness
The permanent magnet 9 to repel each other with 8 magnetism of electromagnet；Chamber in the sealing drum 43 positioned at 42 top of filter plate forms drug storage chamber, institute
It states 42 upper surface of filter plate and is uniformly fixed with the blade 40 of blade upward；Under original state, the elastic force of spring 1 is less than filtering
The gravity of plate 42, filter plate 42 are located at the bottom of sliding slot 45, and the insertion prescribe medicine of Kong Saizhu 49 blocks prescribe medicine hole 48 in hole 48；
As shown in fig. 7, the tablet press mechanism 5 includes driving the Anchor plate kit moved up and down, the pressing plate by hydraulic cylinder 50
Component includes the top board 51 and lower platen 52 of upper and lower face, the center punishment of the forward surface of the top board 51 and lower platen 52
Dui Ying not fix the electromagnetic block 2 53 for being magnetic attracting and permanent magnets 2 54,51 bottom surface of top board and 52 top surface of lower platen it
Between around electromagnetic block 2 53 and permanent magnets 2 54 be equidistantly equipped with spring 2 55, the both ends of the spring 2 55 are separately connected pressure
Plate 51 and lower platen 52；
As shown in Figure 1, the medicament discharge mechanism 6 includes connecing medicine-chest 60 immediately below medicine outlet 11, it is described to connect medicine-chest 60
Bottom surface is equipped with soft rubber cushion 61, can prevent tablet from injuring by a crashing object, as shown in figure 8,3 bottom of load medicine seat, which is equipped with, blocks tabletting die cavity 31
Opening-closing plate 62, the rear side in the corresponding rotation direction of the opening-closing plate 62, which is hinged on, carries 3 bottom of medicine seat, and hinged place is equipped with and turns round
Spring, when the opening-closing plate 62 is in close state at present, bottom attaches 1 upper surface of workbench, the hinged side of the opening-closing plate 62
Opposite side in be equipped with permanent magnets 1, the bore of the medicine outlet 11 is greater than the bore of tabletting die cavity 31, the medicine outlet 11
One group and the magnetic attracting bar permanent magnet 64 of permanent magnets 1 are equipped on the two sidewalls of workbench 1 in the radial direction, often
Multiple permanent magnet monomers of group bar permanent magnet 64 are distributed along to recessed camber line, and the permanent magnet monomer at top and medicine outlet 11
It is not less than the hinged side of opening-closing plate 62 the distance between side corresponding thereto, every group of item along the distance between avris towards tabletting station
The magnetism of multiple permanent magnet monomers of shape permanent magnet 64 is cumulative from top to bottom.
Specifically:
46 upper end of guide rod is fixed with the limited block 8 that width is greater than 46 diameter of guide rod, and 8 top surface of limited block is
Tapered surface.Limited block 8 plays position-limiting action to the stroke that moves up of filter plate 42, and filter plate 42 is prevented to be detached from guide rod 46.
Downwardly projecting fixture block 56 is fixed at 51 bottom center of top board, at the 52 upper surface center of lower platen
Equipped with recessed card slot 57 compatible with fixture block 56, the thickness of the fixture block 56 is equal to the depth of card slot 57, the electromagnetic block
2 53 are set in fixture block 56, and the permanent magnets 2 54 are set in the lower platen 52 immediately below card slot 57.In lower platen 52 to moving up
It moves to when attaching top board 51, fixture block 56 is just caught in card slot 57, can be enhanced top board 51 and be stablized to the promotion of lower platen 52
Property and uniform force application.
The position of the 52 upper surface connecting spring 2 55 of lower platen is equipped with recessed mounting groove 58, the mounting groove 58
Depth is equal to the length after spring 2 55 is extruded, and is fixed with the extension sleeve 59 being vertically arranged in the mounting groove 58, described
Spring 2 55 is sleeved on extension sleeve 59.After lower platen 52 moves in place to top board 51, spring 2 55 is fully located at peace
In tankage 58,51 lower surface of top board can be attached to completely on 52 upper surface of lower platen at this time, can enhance 51 pairs of top board pushings
The promotion stability and uniform force application of plate 52, extension sleeve 59 can play guiding role to the telescopic variation of spring 2 55, prevent
Only spring is distorted.
Load 3 bottom of medicine seat corresponds to and is equipped with and permanent magnets 1 in the position of one 63 place side of permanent magnets on opening-closing plate 62
Magnetic attracting micro- permanent magnets 65, the magnetism of micro- permanent magnets 65 are less than the permanent magnet monomer at 64 top of every group of bar permanent magnet
Magnetism, can guarantee that opening-closing plate 62 can be opened under the attraction of aforementioned permanent magnet monomer.When opening-closing plate 62 is closed, permanent magnets one
63 effect by the magnetic attraction of micro- permanent magnets 65 can ensure that sealing of the opening-closing plate 62 to 31 bottom of tabletting die cavity, and then can prevent
Only medicinal powder is revealed.
Embodiment 2
A kind of Ni Lapani composition of medicine, the component including following parts by weight:
6 parts of Ni Lapani；
4.5 parts of tea polyphenols；
8.5 parts of glucose；
7 parts of aurantiamarin；
2.5 parts of vitamin C；
73 parts of filler；
5 parts of disintegrating agent.
In the present embodiment, the tea polyphenols select Green Tea Polyphenols.The antitumor action of tea polyphenols has obtained the country
Outer related researcher's generally acknowledges, research shows that its bulk composition catechin (accounting for tea polyphenols total amount 70%~80%) plays master
Want effect.And green tea vitamin e rich in, wherein catechin is the one kind for the polyphenol that content is more in plant, peculiar
Not mature taste ingredient, be very strong antioxidant, while green tea can prevent harmful acidic toxins, have high anti-oxidation
Effect, can achieve the effect of preventing ovarian cancer, this is just consistent with the Ni Lapani inhibiting effect for being applied to oophoroma.
In the present embodiment, the filler is the composition of pregelatinized starch and lactose, their mass ratio is 2:1.
In the present embodiment, the disintegrating agent is sodium carboxymethyl starch.
The preparation method of above-mentioned Ni Lapani composition of medicine, includes the following steps:
(I) take 7.25 parts of fillers with Ni Lapani and tea polyphenols are mixed after, crush simultaneously cross 80 meshes, obtain internal layer medicine
Powder；After mixing by glucose, vitamin C, aurantiamarin, disintegrating agent and remaining filler, it after crushing and crossing 80 meshes, obtains
Surface layer medicinal powder；
(ii) direct tablet compressing machine is used, is filled out in tabletting die cavity 31 by surface layer medicinal powder-internal layer medicinal powder-surface layer medicinal powder sequence
Enter medicinal powder, and the mass ratio for the medicinal powder being successively added three times is that 2.5:1:2.5 obtains tablet after direct tablet compressing；
The structure of the direct tablet compressing machine used in above-mentioned steps (ii) is the same as embodiment 1.
Embodiment 3
A kind of Ni Lapani composition of medicine, the component including following parts by weight:
6.5 parts of Ni Lapani；
4 parts of tea polyphenols；
9 parts of glucose；
7 parts of aurantiamarin；
3 parts of vitamin C；
70 parts of filler；
5 parts of disintegrating agent.
In the present embodiment, the tea polyphenols select Green Tea Polyphenols.
In the present embodiment, the filler is the composition of pregelatinized starch and microcrystalline cellulose, their mass ratio
For 1:1.
In the present embodiment, the disintegrating agent is sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose and cross-linked carboxymethyl
The composition of sodium cellulosate, their mass ratio are 2:3:2.
The preparation method of above-mentioned Ni Lapani composition of medicine, includes the following steps:
(I) take 6.92 parts of fillers with Ni Lapani and tea polyphenols are mixed after, crush simultaneously cross 80 meshes, obtain internal layer medicine
Powder；After mixing by glucose, vitamin C, aurantiamarin, disintegrating agent and remaining filler, it after crushing and crossing 80 meshes, obtains
Surface layer medicinal powder；
(ii) direct tablet compressing machine is used, by surface layer medicinal powder-internal layer medicinal powder-surface layer medicinal powder sequence filling in tabletting die cavity
Medicinal powder, and the mass ratio for the medicinal powder being successively added three times is that 2.5:1:2.5 obtains tablet after direct tablet compressing；
The structure of the direct tablet compressing machine used in above-mentioned steps (ii) is the same as embodiment 1.
Embodiment 4
A kind of Ni Lapani composition of medicine, the component including following parts by weight:
7 parts of Ni Lapani；
3.5 parts of tea polyphenols；
9.5 parts of glucose；
6 parts of aurantiamarin；
3.5 parts of vitamin C；
68 parts of filler；
4 parts of disintegrating agent.
In the present embodiment, the tea polyphenols select Green Tea Polyphenols.
In the present embodiment, the filler is the composition of pregelatinized starch, lactose and microcrystalline cellulose, their matter
Amount is than being 3:2:3.
In the present embodiment, the disintegrating agent is the composition of sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose, it
Mass ratio be 2:3.
The preparation method of above-mentioned Ni Lapani composition of medicine, includes the following steps:
(I) take 6.42 parts of fillers with Ni Lapani and tea polyphenols are mixed after, crush simultaneously cross 80 meshes, obtain internal layer medicine
Powder；After mixing by glucose, vitamin C, aurantiamarin, disintegrating agent and remaining filler, it after crushing and crossing 80 meshes, obtains
Surface layer medicinal powder；
(ii) direct tablet compressing machine is used, by surface layer medicinal powder-internal layer medicinal powder-surface layer medicinal powder sequence filling in tabletting die cavity
Medicinal powder, and the mass ratio for the medicinal powder being successively added three times is that 2.5:1:2.5 obtains tablet after direct tablet compressing；
The structure of the direct tablet compressing machine used in above-mentioned steps (ii) is the same as embodiment 1.
Embodiment 5
A kind of Ni Lapani composition of medicine, the component including following parts by weight:
8 parts of Ni Lapani；
3 parts of tea polyphenols；
10 parts of glucose；
5 parts of aurantiamarin；
4 parts of vitamin C；
65 parts of filler；
4 parts of disintegrating agent.
In the present embodiment, the tea polyphenols select Green Tea Polyphenols.
In the present embodiment, the filler is pregelatinized starch.
In the present embodiment, the disintegrating agent is low-substituted hydroxypropyl cellulose.
The preparation method of above-mentioned Ni Lapani composition of medicine, includes the following steps:
(I) take 5.5 parts of fillers with Ni Lapani and tea polyphenols are mixed after, crush simultaneously cross 80 meshes, obtain internal layer medicinal powder；
After mixing by glucose, vitamin C, aurantiamarin, disintegrating agent and remaining filler, after crushing and crossing 80 meshes, table is obtained
Layer medicinal powder；
(ii) direct tablet compressing machine is used, by surface layer medicinal powder-internal layer medicinal powder-surface layer medicinal powder sequence filling in tabletting die cavity
Medicinal powder, and the mass ratio for the medicinal powder being successively added three times is that 2.5:1:2.5 obtains tablet after direct tablet compressing；
The structure of the direct tablet compressing machine used in above-mentioned steps (ii) is the same as embodiment 1.
The specific mechanism of direct tablet compressing machine employed in each embodiment are as follows:
Surface layer medicinal powder obtained is uniformly divided into two parts be respectively placed in first and third into powder mechanism 4, by internal layer medicine
Powder is placed in second into powder mechanism 4, first opening first into powder mechanism 4, to it immediately below the first tabletting mould for carrying medicine seat 3
Part surface layer medicinal powder is inserted in chamber 31；Restart stepper motor 7, rotary shaft 2 is driven to rotate, carries medicine seat 3 and rotate with it, to stepping
When motor 7 suspends, the first load medicine seat 3 is just moved to second underface into powder mechanism 4, at this point, opening the first He simultaneously
The second two, into powder mechanism 4, are inserted portion inner layer medicinal powder in the tabletting die cavity 31 that carries medicine seat 3 to first respectively and carry medicine to second
Part surface layer medicinal powder is inserted in the tabletting die cavity 31 of seat 3；Stepper motor 7 is again started up to when pause, and the first load medicine seat 3 just moves
It moves to third into the underface of powder mechanism 4, at this point, three are opened simultaneously into powder mechanism 4, the tabletting mould for carrying medicine seat 3 to first
Surface layer medicinal powder is inserted in chamber 31, inserts portion inner layer medicinal powder in the tabletting die cavity 31 for carrying medicine seat 3 to second, carries medicine seat 3 to third
Tabletting die cavity 31 in insert part surface layer medicinal powder: stepper motor 7 be again started up to pause when, first load medicine seat 3 just move
To the underface of tablet press mechanism 5, at this point, opening three simultaneously into powder mechanism 4 and tablet press mechanism 5, to the subsequent tabletting for carrying medicine seat 3
The corresponding medicinal powder of filling in die cavity 31, tablet press mechanism 5 squeeze the medicinal powder in the first load medicine seat 3, and tablet is made；Stepper motor
After 7 are again started up, first carries medicine seat 3 to the movement of drug station, and tablet is removed tabletting die cavity 31 at drug station and is collected；
After stepper motor 7 is again started up, the first load medicine seat 3 mobile, pending secondary splendid attire medicinal powder to first into powder station.Thus may be used
Know, the load medicine seat 3 of direct tablet compressing machine provided by the present invention around rotary shaft 2 rotate a circle during complete medicinal powder charging,
The whole process of tabletting and discharging is able to achieve cycle operation, and multiple linking operations carried between medicine seat 3 are more close, each work
Position serialization movement, is conducive to improve working efficiency.
Specifically, into the action principle of powder mechanism 4 are as follows:
Under original state, since the elastic force of spring 1 is less than the gravity of filter plate 42, filter plate 42 is located at sliding slot 45
Bottom, spring are in compressive state, block prescribe medicine hole 48 in the insertion prescribe medicine of Kong Saizhu 49 hole 48, and it is intracavitary that medicinal powder is filled in drug storage,
For medicinal powder after the filtering of filter plate 42, the biggish medicinal powder of partial size is intercepted at 42 top of filter plate；When needing blanking, to electricity
Magnet 8 is powered, and permanent magnet 9 is made filter plate 42 in addition the elastic force of spring 1, overcomes the gravity of filter plate 42 by magnetic repulsion
It pops up, until hole stick harness 49 removes prescribe medicine hole 48, the lesser medicinal powder of partial size passes through filter plate 42 and falls and fall from prescribe medicine hole 48
Under, it can enter in the tabletting die cavity 31 for carrying medicine seat 3, the uniformity that medicinal powder falls into tabletting die cavity 31 is preferable；Then electromagnet 8 is given
Power-off, the magnetic repulsion that permanent magnet 9 is subject to disappear, and the elastic force of spring 1 is not enough to overcome the gravity of filter plate 42, filter plate 42
It moves down, until hole stick harness 49 is inserted into corresponding prescribe medicine hole 48, stops medicinal powder blanking.In addition, start to move up in filter plate 42
Moment and the moment for moving down into bottom, stronger vibrating effect can be all generated, then the blade 40 on 42 upper surface of filter plate can be to grain
The biggish medicinal powder of diameter is cut, to advantageously ensure that making full use of for medicinal powder.
The action principle of tablet press mechanism 5 are as follows:
Under original state, the not carrying magnetic of electromagnetic block 2 53, by the gravity of lower platen 52, so that spring, which is in, stretches shape
State, generates upward elastic force, and top board 51 and lower platen 52 are in discrete state；When sheeting operation to be carried out, electromagnetic block is given
2 53 are powered, and are allowed to generate magnetic attraction to permanent magnets 2 54, in addition the elastic force that spring 2 55 is upward, overcomes the weight of lower platen 52
Power is moved upward to lower platen 52 and is bonded with top board 51, and spring 2 55 is compressed, and downward elastic force is generated；Then start
Hydraulic cylinder 50 drives top board 51 and lower platen 52 to move downwardly together, carries out tabletting to the medicinal powder in tabletting die cavity 31；Tabletting
After, starting hydraulic cylinder 50 moves backward, and drives top board 51 and lower platen 52 to move upwardly together, in the process, gives
Electromagnetic block 2 53 powers off, and is allowed to disappear to the magnetic attraction that permanent magnets 2 54 generate, at this point, the elastic force of spring 2 55 and lower platen 52
Gravity it is downward, flick lower platen 52 quickly downwards in a flash, generate vibrating effect, can will be adhered on lower platen 52
Tablet shake off, play anti-adhesion effects.
The action principle of medicament discharge mechanism 6 are as follows:
It is first when permanent magnets 1 are moved to 64 region of bar permanent magnet during carrying medicine seat 3 and being located at drug station
The permanent magnet monomer of first 11 two sides upper top of medicine outlet generates magnetic attraction to permanent magnets 1, so that opening-closing plate 62 is generated around it
The trend that hinged side rotates down, along with magnetic cumulative multiple permanent magnet monomers successively generate magnetic to permanent magnets 1
Power, at this point, tablet can be fallen from 31 lower port of tabletting die cavity, falls into and connects in medicine-chest 60 so that opening-closing plate 62 fully opens；?
When stepper motor 7 continues that the load medicine seat 3 is driven to move to first into medicine station, once permanent magnets 1 are located at permanent magnet monomer
Attractived region except, under the action of torsional spring, opening-closing plate 62 be just capable of resetting to block tabletting die cavity 31 position.
As shown in the above, the direct tablet compressing function used in Preparation Method provided by system of the present invention improves the grain of medicinal powder
Diameter uniformity and charging uniformity, can prevent tablet from sticking on pressing plate, and discharge effect optimization, and working efficiency is higher.
Those of ordinary skill in the art it should be appreciated that more than embodiment be intended merely to illustrate the present invention,
And be not used as limitation of the invention, as long as the change in spirit of the invention, to embodiment described above
Change, modification will all be fallen in scope of the presently claimed invention.
Claims (8)
1. a kind of Ni Lapani composition of medicine, which is characterized in that the component including following parts by weight:
5-8 parts of Ni Lapani；
3-5 parts of tea polyphenols；
8-10 parts of glucose；
5-8 parts of aurantiamarin；
2-4 parts of vitamin C；
65-75 parts of filler；
4-5 parts of disintegrating agent；
The preparation method of above-mentioned Ni Lapani composition of medicine, includes the following steps:
(I) take partially filled agent with Ni Lapani and tea polyphenols are mixed after, crush simultaneously cross 80 meshes, obtain internal layer medicinal powder；By Portugal
Grape sugar, vitamin C, aurantiamarin, disintegrating agent and remaining filler after mixing, after crushing and crossing 80 meshes, obtain surface layer medicine
Powder, and the mass ratio of internal layer medicinal powder and surface layer medicinal powder is 1:5；
(ii) direct tablet compressing machine is used, inserts medicine by surface layer medicinal powder-internal layer medicinal powder-surface layer medicinal powder sequence in tabletting die cavity
Powder, and the mass ratio for the medicinal powder being successively added three times is that 2.5:1:2.5 obtains tablet after direct tablet compressing；
The structure of the direct tablet compressing machine used in step (ii) are as follows:
Including workbench (1), rotary shaft (2), carry medicine seat (3), into powder mechanism (4), tablet press mechanism (5) and medicament discharge mechanism (6)；
The rotary shaft (2) passes through at workbench (1) center, and it includes successively uniformly setting that the workbench (1), which revolves around it axis (2),
Three set are each designed with one into powder into powder station surface into powder station, a tabletting station and a drug station
Mechanism (4), the tablet press mechanism (5) be set to tabletting station surface, the medicament discharge mechanism (6) be set to drug station just under
It is square, fan-shaped medicine outlet (11) are offered on the workbench (1) at the drug station；The rotary shaft (2) is located at work
Position above platform (1) is fixed with along its border to be carried medicine seat (3) correspondingly with each station, and described rotary shaft (2) one end connects
It connects stepper motor (7), load medicine seat (3) is successively passed through around the rotation of rotary shaft (2) into powder station, tabletting station and drug work
Position, a rotational angle of the stepper motor (7) are equal to the angle between two neighboring station；It is set on the load medicine seat (3)
Have be vertically arranged in straight-cylindrical tabletting die cavity (31), the bore of the tabletting die cavity (31) is less than the width of medicine outlet (11)
Degree；
It is described to include horizontally disposed fixed plate (41) and sliding right above fixed plate (41) into powder mechanism (4) and be parallel to
The filter plate (42) of fixed plate (41), be fixed on fixed plate (41) periphery inner wall be bonded with filter plate (42) side it is close
Sealed tube (43), filter plate (42) side are equidistantly fixed with sliding block (44), and sealing drum (43) inner wall is equipped with for cunning
The sliding slot (45) that block (44) moves up and down offers locating slot at fixed plate (41) center, is fixed in the locating slot
The guide rod (46) being vertically arranged, guide rod (46) upper end passes through at filter plate (42) center, on the guide rod (46)
It is arranged with the spring one (47) that both ends are separately connected fixed plate (41) and filter plate (42)；It is evenly distributed on the filter plate (42)
Filter opening, prescribe medicine hole (48) is evenly distributed on the fixed plate (41), and filter plate (42) bottom surface is fixed with and prescribe medicine hole (48)
The hole stick harness (49) of prescribe medicine hole (48) is aligned and can just be inserted into one by one, is equipped in the fixed plate (41) and is located at prescribe medicine hole (48)
The electromagnet (8) of lower outside, is equipped in hole stick harness (49) lower end and the magnetic permanent magnet (9) to repel each other of electromagnet (8)；Institute
It states the chamber in sealing drum (43) above filter plate (42) and forms drug storage chamber, filter plate (42) upper surface is uniformly fixed
There is the blade (40) of blade upward；Under original state, the elastic force of spring one (47) is less than the gravity of filter plate (42), filter plate
(42) it is located at the bottom of sliding slot (45), blocks prescribe medicine hole (48) in Kong Saizhu (49) insertion prescribe medicine hole (48)；
The tablet press mechanism (5) includes driving the Anchor plate kit moved up and down by hydraulic cylinder (50), and the Anchor plate kit includes upper
Distinguish at the center of the forward surface of the top board (51) and lower platen (52) of lower face, the top board (51) and lower platen (52)
The corresponding fixed electromagnetic block two (53) and permanent magnets two (54), top board (53) bottom surface and lower platen (54) for being magnetic attracting
It is equidistant equipped with spring two (55) around electromagnetic block two (53) and permanent magnets two (54) between top surface, the two of the spring two (55)
End is separately connected top board (51) and lower platen (52)；
The medicament discharge mechanism (6) includes connecing medicine-chest (60) immediately below medicine outlet (11), described to connect medicine-chest (60) bottom surface paving
Equipped with soft rubber cushion (61), medicine seat (3) bottom that carries is equipped with the opening-closing plate (62) for blocking tabletting die cavity (31), the opening-closing plate
(62) rear side in corresponding rotation direction, which is hinged on, carries medicine seat (3) bottom, and hinged place is equipped with torsional spring, at the opening-closing plate (62)
In closed state at present when, bottom attaches worktable upper surface, equipped with forever in the opposite side of the hinged side of the opening-closing plate (62)
Magnetic patch one (63), the bore of the medicine outlet (11) are greater than the bore of tabletting die cavity (31), and the medicine outlet (11) is in workbench
One group and the magnetic attracting bar permanent magnet (64) of permanent magnets one (63), every group of bar shaped are equipped on two sidewalls in the radial direction
Multiple permanent magnet monomers of permanent magnet (64) are distributed along to recessed camber line, and the permanent magnet monomer at top and medicine outlet (11) court
It is not less than opening-closing plate (62) hinged side the distance between side corresponding thereto, every group of item along the distance between avris to tabletting station
The magnetism of multiple permanent magnet monomers of shape permanent magnet (64) is cumulative from top to bottom.
2. a kind of Ni Lapani composition of medicine according to claim 1, which is characterized in that the tea polyphenols select green tea tea
Polyphenol.
3. a kind of Ni Lapani composition of medicine according to claim 1, which is characterized in that the filler is pregelatinated shallow lake
The composition of any one or more in powder, lactose and microcrystalline cellulose.
4. a kind of Ni Lapani composition of medicine according to claim 1, which is characterized in that the disintegrating agent is carboxymethyl shallow lake
The composition of any one or more in powder sodium, low-substituted hydroxypropyl cellulose and croscarmellose sodium.
5. Ni Lapani composition of medicine according to claim 1, which is characterized in that the direct tablet compressing machine that preparation method uses
Guide rod (46) upper end be fixed with width be greater than guide rod (46) diameter limited block (10), limited block (10) top surface is
Tapered surface.
6. Ni Lapani composition of medicine according to claim 1, which is characterized in that the direct tablet compressing machine that preparation method uses
Top board (51) bottom center at be fixed with downwardly projecting fixture block (56), be equipped at lower platen (52) the upper surface center
The recessed compatible card slot (57) with fixture block (56), the thickness of the fixture block (56) are equal to the depth of card slot (57), the electricity
Magnetic patch two (53) is set in fixture block (56), and the permanent magnets two (54) are set in the lower platen (52) immediately below card slot (57).
7. Ni Lapani composition of medicine according to claim 1, which is characterized in that the direct tablet compressing machine that preparation method uses
Lower platen (52) upper surface connecting spring two (55) position be equipped with recessed mounting groove (58), the depth of the mounting groove (58)
Degree is equal to the length after spring two (55) is extruded, and is fixed with the extension sleeve (59) being vertically arranged in the mounting groove (58),
The spring two (55) is sleeved on extension sleeve (59).
8. Ni Lapani composition of medicine according to claim 1, which is characterized in that the load medicine seat (3) that preparation method uses
It is equipped in the position of side where bottom corresponds to permanent magnets one (63) on opening-closing plate (62) and attracting micro- of permanent magnets one (63) magnetism
Permanent magnets (65), the magnetism of micro- permanent magnets (65) are less than the magnetic of the permanent magnet monomer at the top of every group of bar permanent magnet (64)
Property.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910190003.9A CN110038011A (en) | 2019-03-13 | 2019-03-13 | A kind of Ni Lapani composition of medicine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910190003.9A CN110038011A (en) | 2019-03-13 | 2019-03-13 | A kind of Ni Lapani composition of medicine and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110038011A true CN110038011A (en) | 2019-07-23 |
Family
ID=67273719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910190003.9A Pending CN110038011A (en) | 2019-03-13 | 2019-03-13 | A kind of Ni Lapani composition of medicine and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110038011A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108201537A (en) * | 2016-12-16 | 2018-06-26 | 苏州苏融生物医药有限公司 | A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof |
-
2019
- 2019-03-13 CN CN201910190003.9A patent/CN110038011A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108201537A (en) * | 2016-12-16 | 2018-06-26 | 苏州苏融生物医药有限公司 | A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| ZHAO JUN等: "Hesperidin inhibits ovarian cancer cell viability through endoplasmicreticulum stress signaling pathways", 《ONCOLOGY LETTERS》 * |
| 张焕金等: "绿茶提取物茶多酚抗癌作用的研究进展", 《华南国防医学杂志》 * |
| 韩宇等: "尼拉帕尼（Niraparib）", 《中国药物化学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6713001B2 (en) | Pharmaceutical composition containing silybin, VE, and L-carnitine | |
| CN208275553U (en) | Pharmacy's medicinal material grinding device | |
| CN103099793B (en) | Tablet and preparation method | |
| CN103608024B (en) | Control the pharmaceutical composition of blood glucose, blood fat and body weight | |
| CN101926891A (en) | Composition for losing weight | |
| CN105288215A (en) | High-activity dendrobium officinale kimura et migo freeze-drying powder buccal tablets and preparation process thereof | |
| CN110038011A (en) | A kind of Ni Lapani composition of medicine and preparation method thereof | |
| CN103182009A (en) | Hypolipidemic traditional Chinese medicine composition and preparation method and application thereof | |
| CN101966316B (en) | Gujin pill pellet and preparation method thereof | |
| CN101049429A (en) | Tablet for regulating menstruation and removing speckles of department of gynecology, and preparation method | |
| CN108295181A (en) | meridian tea | |
| CN113940891A (en) | Medical Chinese herbal medicine pill forming device | |
| CN109806169A (en) | A kind of preparation facilities of Tibetan medicine pill and preparation method thereof | |
| CN213408809U (en) | Solid medicine reducing mechanism for paediatrics | |
| CN102283892A (en) | Preparation technology and production method of integrated novel Sanzi Yangqin decoction dosage form | |
| CN103599343A (en) | Pharmaceutical composition for treating diabetes, and preparation method and application thereof | |
| CN102772439A (en) | Processing method of ultra-micro wall-breaking capsule-preparation decoction pieces by traditional Chinese medicines | |
| CN209900108U (en) | Capsule filling device | |
| CN204446627U (en) | A kind of sheeting system | |
| CN103877323B (en) | Medicinal composition for treating non-alcoholic fatty liver disease | |
| CN209597342U (en) | A manufacture traditional Chinese medicine freckle-removing Deacne pack powder device | |
| CN209361352U (en) | A kind of preparation facilities of Tibetan medicine pill | |
| CN103006725A (en) | Medical composition for treating diabetes mellitus with hyperlipaemia and preparation method thereof | |
| CN1449799A (en) | Traditional Chinese medicine injection for treating tumor and preparation process thereof | |
| CN206778915U (en) | A kind of pharmaceutical screening plant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190723 |