CN110037831B

CN110037831B - Pig pericardium valve leaf processing apparatus

Info

Publication number: CN110037831B
Application number: CN201910365638.8A
Authority: CN
Inventors: 王雪丽; 朱涛; 胡芬芬; 孙明
Original assignee: Wuhan Weike Medical Technology Co ltd
Current assignee: Wuhan Weike Medical Technology Co ltd
Priority date: 2019-05-02
Filing date: 2019-05-02
Publication date: 2020-10-09
Anticipated expiration: 2039-05-02
Also published as: CN110037831A

Abstract

The invention discloses a porcine pericardium valve leaflet processing device, which comprises a processing mechanism and an intelligent control mechanism, wherein the processing mechanism comprises a first control mechanism and a second control mechanism; the processing mechanism comprises a processing box, a solution box and a driving box; the processing box is internally provided with a placing box and a shaking unit for shaking the placing box, the placing box is provided with a leaching unit on the inner wall of the processing box which is provided with an upper arc body and a lower arc body with hollow structures and can be detached, the leaching unit comprises a plurality of spray heads facing the placing box, a heating box for the placing box to come in and go out and a cooling box for the placing box to come in and go out are detachably connected to a box cover, and the heating box and the cooling box are both unsealed boxes; and a leaching liquid storage bottle, a decellularization liquid storage bottle and an anti-calcification liquid storage bottle are arranged in the solution tank. The invention has simple structure and reasonable design, can perform operations of cell removal, calcification prevention and multiple cleaning on the pig heart bags in the treatment box, does not need to repeatedly move the pig heart bags, avoids the damage to the performance of the pig heart bags in the moving process, and has the functions of heating, cooling, shaking and leaching and the like.

Description

Pig pericardium valve leaf processing apparatus

Technical Field

The invention belongs to the technical field of biomedicine, and particularly relates to an anti-calcification porcine pericardium valve leaflet processing device.

Background

In recent years, the incidence of heart valve-like disease has continued to rise worldwide, with the total number of valve replacements expected to increase from 29 million in 2003 to 85 million in 2050. Clinically, conventional replacement regimens are dominated by mechanical and biological valve replacement.

Mechanical valves have the advantage of being durable, and have the disadvantage that patients who receive mechanical valves need long-term anticoagulation treatment, the probability of postoperative thrombosis and anticoagulation complications is high, and the anticoagulation treatment has certain influence on non-cardiac surgery and women of childbearing age of patients, so that the mechanical valves are not suitable for patients with anticoagulation treatment countersigns, women who wish to breed and elderly patients with short life, and are gradually replaced by biological valves in recent years.

Biological valves are a class of high-tech materials used in the diagnosis, repair or enhancement of the function of human tissues and organs, natural or artificial materials used to replace, repair, etc. living tissue of the human body. The biological valve has the advantages that long-term anticoagulation treatment is not needed after operation, and is particularly suitable for patients who are not suitable for long-term anticoagulation treatment, and the biological valve has the defect that the biological valve is easy to degenerate and the valve is narrowed or calcified again.

At present, the biological valve only needs to be from two types of porcine pericardium and bovine pericardium. The average service life of the porcine pericardium biological valve is 5 years, and the average service life of the bovine pericardium biological valve is 7 to 8 years. In recent years, foreign scholars find that the porcine pericardium valve material not only has good biocompatibility and better degradation and absorption rate, but also finds that the specific tissue structure of the porcine pericardium valve material is more beneficial to the invasion of peripheral capillary vessels into a collagen membrane, is beneficial to the running of nutrient components and mineral ions, and plays an important role in the bone regeneration process.

However, porcine pericardial valve material also presents a number of problems in use.

One of the problems is that after being implanted into a human body, the treated pig heart valve-wrapping material has the phenomena of serious late calcification, high degeneration and functional decay rate, a large amount of tissue matrix is lost, the biomechanical performance is reduced, and the valve leaf decay rate is high, wherein a low-age patient is more obvious, the service life of the patient is seriously influenced, the service performance and the expected life of the pig heart valve-wrapping material are directly influenced, and the risk of secondary operation implantation is caused, so that the calcification problem of the pig heart valve-wrapping material is always a difficult problem in the biomedical field. At present, the means for carrying out anti-calcification on the pig heart valve-wrapping material mainly comprises the step of treating the pig heart valve-wrapping material by adopting a natural macromolecular compound solution or a surfactant solution, the anti-calcification performance of the pig heart valve-wrapping material treated by the anti-calcification treatment method is obviously improved, but the treatment process involves various operations, the pig heart valve-wrapping material needs to be folded and stored in a plurality of containers, and the operation process is complicated and complicated.

Another problem is that the introduction of chemical reagents during the treatment process can cause the biological safety problem, and during the treatment process, most of the washing for the chemical reagents is rinsed for many times by using non-toxic and harmless chemical solvents, and the rinsing is performed manually, so that the risk of incomplete and irregular rinsing exists. Certain residual chemical reagents have certain cytotoxic effects, so that the pig pericardium biological valve has poor performance, the problems of damage and even delamination of the pig pericardium biological valve and the like are easily caused, the fatigue resistance and the service life of a biological material are influenced, and the biocompatibility of the pig pericardium biological valve is influenced more directly.

Therefore, a novel porcine pericardium valve leaflet treatment device which has an anti-calcification function and high rinsing efficiency and can carry out integrated treatment on the porcine pericardium biological valve is needed.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a porcine pericardium leaflet processing device aiming at the defects in the prior art, which has the advantages of simple structure and reasonable design, can perform operations of cell removal, calcification prevention and repeated cleaning on a porcine pericardium in a processing box, does not need to repeatedly move the porcine pericardium, avoids the damage to the performance of the porcine pericardium in the moving process, adopts drip washing to replace the traditional rinsing, has the liquidity of solution in the processing box, can effectively remove chemical reagents adhered to the surface of the porcine pericardium, has good cleaning effect, and has the functions of heating, cooling and the like.

In order to solve the technical problems, the invention adopts the technical scheme that: a pig pericardium leaflet processing apparatus which characterized in that: comprises a processing mechanism and an intelligent control mechanism electrically connected with the processing mechanism; the processing mechanism comprises a processing box, a solution box and a driving box; the processing box is internally provided with a placing box for placing a porcine pericardium and a shaking unit for shaking the placing box, the placing box is formed by detachably connecting an upper arc body and a lower arc body, the upper arc body and the lower arc body are both of hollow structures, the inner wall of the placing box is a smooth inner wall, the inner wall of the processing box is provided with a leaching unit, the leaching unit comprises a plurality of spray heads facing the placing box, the top of the processing box is provided with a decellularized liquid inlet hole, an anti-calcification liquid inlet hole and a through hole for the placing box to come in and go out, the bottom of the processing box is provided with a liquid outlet hole, the processing box is provided with a box cover matched with the through hole, the box cover is detachably connected with a heating box for the placing box to come in and go out and a cooling box for the placing box to come in and go out, and the heating box and the cooling box are both unsealed boxes; a leaching liquid storage bottle, a decellularization liquid storage bottle and an anti-calcification liquid storage bottle are arranged in the solution tank; and a leaching pump used for connecting the leaching liquid storage bottle and the leaching unit, a decellularization pump used for connecting the decellularization liquid storage bottle and the decellularization liquid inlet hole, a calcification-preventing pump used for connecting the calcification-preventing liquid storage bottle and the calcification-preventing liquid inlet hole and a liquid discharge pump connected with the liquid discharge hole are arranged in the driving box.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: the heating box is characterized in that a heating component is arranged in the interlayer of the box wall of the heating box, a charging circuit, a charging battery and a heating driving module are arranged in the box cover, the charging circuit, the charging battery and the heating driving module are connected with the heating component, a heating access groove is formed in the top end of the box wall of the heating box, the heating access groove is electrically connected with the heating component, a contact is arranged at the bottom of the box cover, and the heating access groove is matched with the contact.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: a switch module exposed out of the box cover is arranged between the rechargeable battery and the heating driving module, a contact sliding groove is formed in the bottom of the box cover, and the switch module can enable the contact to move in the contact sliding groove.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: the intelligent control mechanism comprises a PLC module, a touch screen connected with the PLC module, a countdown module and a temperature sensor arranged in a heating box, wherein the output end of the PLC module is connected with a heating driving module, a calcification-preventing driving module used for connecting the calcification-preventing pump, a leaching driving module used for connecting the leaching pump, a shaking driving module used for connecting a shaking motor, a decellularization driving module used for connecting the decellularization pump and a liquid discharge driving module used for connecting the liquid discharge pump.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: the placing box consists of a high-temperature resistant layer and a heat insulating layer from inside to outside.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: the cooling box is characterized in that a cooling pipeline is arranged in the interlayer of the box wall of the cooling box, a charging circuit, a charging battery and a cooling driving module are arranged in the box cover, the charging circuit, the charging battery and the cooling driving module are connected with the cooling pipeline, the cooling access groove is formed in the top end of the box wall of the cooling box, the cooling access groove is electrically connected with the cooling pipeline, a contact is arranged at the bottom of the box cover, and the cooling access groove is matched with the contact.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: handle the incasement and be provided with electric telescopic handle, electric telescopic handle can dismantle with placing the box and be connected, it includes the subbox that sets up at handling the bottom of the case to rock the unit, the subbox is provided with and rocks the motor, the connecting hole has been seted up to the bottom of handling the case, electric telescopic handle passes the connecting hole and meets with the output shaft that rocks the motor.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: the number of the electric telescopic rods is multiple.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: and a leaching liquid inlet pipe, a liquid discharge pipe, a cell-removing liquid inlet pipe and an anti-calcification liquid inlet pipe are arranged in the interlayer of the box wall of the treatment box.

Foretell pig pericardium valve leaf processing apparatus which characterized in that: the number of the leaching units is multiple, and the leaching units are respectively arranged on the inner wall of the treatment box.

Compared with the prior art, the invention has the following advantages:

1. the invention has simple structure, reasonable design and convenient realization, use and operation.

2. According to the invention, the electric telescopic rods are arranged in the treatment box, the number of the electric telescopic rods is at least two, and when the telescopic lengths of at least two electric telescopic rods are different, namely the rotating speeds of the shaking motors for driving the electric telescopic rods are asynchronous, the purpose of shaking the placing box can be achieved, so that the washing force on the pig heart bags is increased, and the washing cleanliness is improved.

3. According to the invention, the placing box consists of the upper arc body and the lower arc body, and the inner wall of the placing box is a smooth inner wall, so that the placing box cannot damage the pig heart bag and the like, and the using effect is good.

4. According to the invention, the inner wall of the treatment box is provided with the leaching unit, the leaching unit comprises a plurality of spray heads facing the placing box, and the upper arc body and the lower arc body of the placing box are both of hollow structures, so that the hollow structures of the placing box can be contacted with the pig heart bags by the solution, and the effect of comprehensive leaching is achieved. Compared with rinsing, the solution in the treatment box is flowable, chemical reagents attached to the surface of the porcine pericardium can be effectively removed, and the use effect is good.

5. The pig heart bag cleaning device can perform operations of decellularization, calcification prevention and multiple cleaning on the pig heart bag in the treatment box, so that the pig heart bag does not need to be repeatedly moved in the processes of decellularization, calcification prevention and multiple cleaning, and the damage to the performance of the pig heart bag in the moving process is avoided.

6. The heating box capable of accommodating the placing box and the cooling box capable of accommodating the placing box are both unsealed box bodies, so that a solution entering the heating box or the cooling box can be heated or cooled, the function of heating or cooling the pig heart bags in the placing box is indirectly realized, the requirements on temperature under different operating conditions are met, the applicability is wide, and the using effect is good.

In conclusion, the pig heart bag cleaning device is simple in structure and reasonable in design, can perform operations of cell removal, calcification prevention and repeated cleaning on the pig heart bag in the treatment box, does not need to repeatedly move the pig heart bag, avoids damage to the performance of the pig heart bag in the moving process, adopts leaching to replace traditional rinsing, is flowable in solution in the treatment box, can effectively remove chemical reagents attached to the surface of the pig heart bag, is good in cleaning effect, and has the functions of heating, cooling and the like.

The technical solution of the present invention is further described in detail by the accompanying drawings and embodiments.

Drawings

FIG. 1 is a schematic structural diagram of the present invention.

FIG. 2 is a schematic view showing the connection between the cover and the heating box according to the present invention.

FIG. 3 is a schematic view of the connection between the case cover and the cooling case according to the present invention.

FIG. 4 is a cross-sectional view of a treatment tank of the present invention.

FIG. 5 is a schematic block diagram of the circuit of the intelligent control mechanism of the present invention.

Fig. 6 is a schematic block circuit diagram of the heating cabinet of the present invention.

Fig. 7 is a schematic block diagram of the circuit of the cooling box of the present invention.

Description of reference numerals:

1-treatment box; 2-a solution tank; 3, driving a box;

4-leaching unit; 5, placing a box; 6, an electric telescopic rod;

7, a box cover; 8-cell-free liquid inlet hole; 9-calcification-proof liquid inlet hole;

10-liquid discharge hole; 11-subbox; 12-a touch screen;

13-a PLC module; 14-a temperature sensor; 15-heating driving module;

16-a switch module; 17-a heating assembly; 18-anti-calcification driving module;

19-leaching the driving module; 20-shaking the driving module; 21-decellularization driving module;

22-countdown module; 23-a heating box; 24-a spray header;

25-a leaching pump; 26-shaking motor; 27-a decellularization pump;

28-calcification prevention liquid storage bottle; 29-leaching the liquid storage bottle; 30-cell-free liquid storage bottle;

31-a drainage driving module; 32-a positive displacement pump; 33-tank wall interlayer;

34-a cooling box; 35-a cooling pipeline; 36-a rechargeable battery;

37-charging circuit.

Detailed Description

The method of the present invention will be described in further detail below with reference to the accompanying drawings and embodiments of the invention.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are, for example, capable of operation in sequences other than those illustrated or otherwise described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

As shown in fig. 1 to 7, the present invention comprises a processing mechanism and an intelligent control mechanism electrically connected with the processing mechanism, wherein the processing mechanism comprises a processing tank 1, a solution tank 2 and a driving tank 3; a placing box 5 for placing the porcine pericardium and a shaking unit for shaking the placing box 5 are arranged in the treatment box 1, the placing box 5 is formed by detachably connecting an upper arc body and a lower arc body, the upper arc body and the lower arc body are both hollow structures, the inner wall of the placing box 5 is a smooth inner wall, the inner wall of the processing box 1 is provided with a leaching unit 4, the leaching unit 4 comprises a plurality of spray heads 24 facing the placing box 5, the top of the processing box 1 is provided with a decellularization liquid inlet hole 8, a calcification-proof liquid inlet hole 9 and a through hole for the placing box 5 to come in and go out, a liquid discharge hole 10 is arranged at the bottom of the treatment box 1, the treatment box 1 is provided with a box cover 7 matched with the through hole, the box cover is detachably connected with a heating box 23 which can be used for the placing box 5 to go in and out and a cooling box 34 which can be used for the placing box 5 to go in and out, and the heating box 23 and the cooling box 34 are both unsealed boxes; a leaching liquid storage bottle 29, a decellularization liquid storage bottle 30 and a calcification-preventing liquid storage bottle 28 are arranged in the solution tank 2; and a leaching pump 25 for connecting a leaching liquid storage bottle 29 and the leaching unit 4, a decellularization pump 27 for connecting a decellularization liquid storage bottle 30 and the decellularization liquid inlet hole 8, an anti-calcification pump for connecting an anti-calcification liquid storage bottle 28 and the anti-calcification liquid inlet hole 9 and a liquid discharge pump 32 connected with the liquid discharge hole 10 are arranged in the driving box 3.

During the specific use, place box 5 and can dismantle the connection by last arc body and arc body down and constitute, be the lock during actual use. The upper arc body and the lower arc body are disassembled, the pig pericardium is placed in the placing box 5, then the upper arc body and the lower arc body are buckled, then the box cover 7 is opened, and the placing box 5 is placed in the treating box 1 through a through hole in the top of the treating box 1.

During the in-service use, be provided with electric telescopic handle 6 in the processing case 1, be provided with in the subbox 11 of processing case 1 bottom and rock motor 26, the connecting hole has been seted up to the bottom of processing case 1, electric telescopic handle 6 passes the connecting hole and meets with the output shaft that rocks motor 26, consequently, the drive rocks motor 26, steerable electric telescopic handle 6's length, adopt same rotational speed and torque to control electric telescopic handle 6, make the same height of electric telescopic handle 6 extension, thereby make electric telescopic handle 6 stretch out the through-hole, then will place box 5 and can dismantle with electric telescopic handle 6 and be connected, during the in-service use, this can dismantle the connection and adopt the couple to connect.

And then the shaking motor 26 is driven to control the electric telescopic rod 6 by adopting the same rotating speed and torque, so that the electric telescopic rod 6 retracts by the same length, and the placing box 5 is placed in the processing box 1 in a suspended mode.

Because place box 5 by last arc body and lower arc body constitution, the inner wall of placing box 5 is smooth inner wall, consequently place box 5 and can not cause damage such as scratching to the pig heart package, excellent in use effect.

During the actual use, set up drip washing unit 4 on handling the inner wall of case 1, drip washing unit 4 includes that a plurality of orientation place the shower head 24 of box 5, consequently can be to placing box 5 spray solution through shower head 24, owing to the last arc body and the lower arc body of placing box 5 are hollow out construction, consequently the solution can be with placing box 5's hollow out construction and the contact of pig heart package to reach the effect of comprehensive drip washing. Compared with rinsing, the solution in the application is flowable, can effectively remove chemical reagents attached to the surface of the porcine pericardium, and has a good using effect.

Considering that the pig heart bag needs to be subjected to cell removal, calcification prevention and multiple cleaning in the treatment process, a leaching liquid storage bottle 29, a cell removal liquid storage bottle 30 and a calcification prevention liquid storage bottle 28 are arranged in the solution tank 2. The number of the leaching liquid storage bottles 29, the decellularization liquid storage bottles 30 and the calcification-prevention liquid storage bottles 28 is one or more, and is determined according to the use condition. The arrangement ensures that the pig pericardium does not need to be repeatedly moved in the processes of decellularization, calcification prevention and multiple cleaning, thereby avoiding the damage to the performance of the pig pericardium in the moving process.

In order to realize automatic liquid feeding, a leaching pump 25 for connecting a leaching liquid storage bottle 29 and the leaching unit 4, a decellularization pump 27 for connecting a decellularization liquid storage bottle 30 and the decellularization liquid inlet hole 8, an anti-calcification pump for connecting an anti-calcification liquid storage bottle 28 and the anti-calcification liquid inlet hole 9, and a liquid discharge pump 32 connected with the liquid discharge hole 10 are arranged in the driving box 3. When the shower head is actually used, the shower pump 25 pumps the shower solution in the shower solution storage bottle 29 to the shower unit 4, and the shower solution is sprayed to the pig heart bags through the shower head 24; the treated waste liquid is pumped out of the treatment tank 1 through the drain hole 10 by the drain pump 32.

The decellularization pump 27 pumps the decellularization solution in the decellularization liquid storage bottle 30 into the treatment box 1 through the decellularization liquid inlet hole 8, so that the pig heart bag is soaked in the decellularization solution and is used for carrying out decellularization treatment on the pig heart bag; the treated waste liquid is pumped out of the treatment tank 1 through the drain hole 10 by the drain pump 32.

The calcification-preventing pump pumps the calcification-preventing solution in the calcification-preventing liquid storage bottle 28 into the treatment box 1 through the calcification-preventing liquid inlet hole 9, so that the pig heart bag is soaked in the calcification-preventing solution and is used for carrying out calcification-preventing treatment on the pig heart bag, and the treated waste liquid is pumped out of the treatment box 1 from the liquid outlet hole 10 through the liquid outlet pump 32.

When the pig pericardium is used specifically, 35 ℃ is usually needed when the cell removing operation is carried out, 10 ℃ to 40 ℃ is usually needed when the calcification preventing operation is carried out, and room temperature is generally needed when the pig pericardium is cleaned, so that the heating box 23 and the cooling box 34 are arranged. The heating cabinet 23 and the cooling cabinet 34 all can supply to place the box 5 and come in and go out, and the heating cabinet 23 and the cooling cabinet 34 are unsealed case to solution to get into in the heating cabinet 23 or the cooling cabinet 34 heats or cools down, has indirectly realized providing the function of heating or cooling to the pig heart package of placing in the box 5.

As shown in fig. 2, in this embodiment, a heating module 17 is disposed in an interlayer of a wall of the heating box 23, a charging circuit 37, a charging battery 36 and a heating driving module 15 connected to the heating module 17 are disposed in the box cover 7, a heating access slot electrically connected to the heating module 17 is disposed at a top end of the wall of the heating box 23, and a contact electrically connected to the heating driving module 15 is disposed at a bottom of the box cover 7, and the heating access slot is adapted to the contact.

When the electric heating and cooling box is used specifically, the placing box 5 is not connected with the electric telescopic rod 6 but is directly placed in the heating box 23 or the cooling box 34 when the heating or cooling is needed. In actual use, the placing box 5 consists of a high temperature resistant layer and a heat insulating layer from the inside to the outside.

Through the rechargeable battery 36 that sets up in case lid 7 to heating element 17 provide the electric energy to the realization heats or cools down the solution that gets into in heating cabinet 23 or cooling box 34, has indirectly realized providing the function of heating or cooling to the pig heart package of placing in the box 5, satisfies the demand to the temperature under the different operating condition, excellent in use effect.

In practical use, the cover 7 is magnetically connected with the heating box 23, a magnetic element such as an iron sheet is arranged at the bottom of the cover 7, and a magnet attracted with the iron sheet is arranged in the wall of the heating box 23. Similarly, the wall of the cooling box 34 is also provided with a magnet which is attracted with the iron sheet.

As shown in fig. 2, in the present embodiment, a switch module 16 exposed out of the case cover 7 is disposed between the rechargeable battery 36 and the heating driving module 15, a contact sliding slot is formed at the bottom of the case cover 7, and the switch module 16 can make the contact move in the contact sliding slot.

When the heating box is used specifically, after the box cover 7 is connected with the heating box 23, the position of the contact at the bottom of the box cover 7 can be changed by sliding the switch module 16, so that the contact is electrically connected with the heating access groove at the top end of the box wall of the heating box 23, and the heating component 17 is heated in an electrified manner.

As shown in fig. 5, in this embodiment, the intelligent control mechanism includes a PLC module 13, a touch screen 12 connected to the PLC module 13, a countdown module 22, and a temperature sensor 14 disposed in a heating box 23, and the output end of the PLC module 13 is connected to a heating driving module 15, an calcification prevention driving module 18 connected to a calcification prevention pump, a washing driving module 19 connected to a washing pump 25, a shaking driving module 20 connected to a shaking motor 26, a decellularization driving module 21 connected to a decellularization pump 27, and a liquid drainage driving module 31 connected to a liquid drainage pump 32.

Note that the swing motor 26 is a stepping motor. The PLC module 13 is arranged in the interlayer 33 of the wall of the treatment box 1, and in the invention, the PLC module 13, the touch screen 12, the countdown module 22, the heating driving module 15, the calcification-preventing driving module 18, the leaching driving module 19, the shaking driving module 20, the decellularization driving module 21 and the liquid discharge driving module 31 are all prior art devices and can be directly purchased and connected with the PLC module 13 for use.

During the specific use, temperature sensor 14 is used for detecting the temperature in heating cabinet 23 to the temperature that will detect obtains gives PLC module 13, and PLC module 13 shows received temperature through touch-sensitive screen 12, so that the experimenter refers to.

Since the operations of decellularization, calcification prevention and cleaning are limited in time, the countdown module 22 is provided in the intelligent control mechanism, and the countdown module 22 includes an input keyboard and a buzzer during actual use. The timing duration is input through the input keyboard, the timing is carried out through the PLC module 13, and when the timing of the PLC module 13 is equal to the timing duration input through the touch screen 12, the PLC module 13 triggers the countdown module 22, so that the buzzer buzzes, and the countdown function is realized.

As shown in fig. 3, in this embodiment, a cooling pipe 35 is disposed in an interlayer of a box wall of the cooling box 34, a charging circuit 37, a charging battery 36 and a cooling driving module connected to the cooling pipe 35 are disposed in the box cover 7, a cooling access slot electrically connected to the cooling pipe 35 is disposed at a top end of the box wall of the cooling box 34, a contact electrically connected to the cooling driving module is disposed at a bottom of the box cover 7, and the cooling access slot is adapted to the contact.

In this embodiment, the number of the electric telescopic rods 6 is plural.

When the electric telescopic rod is used specifically, the number of the electric telescopic rods 6 is at least two. When the telescopic lengths of the at least two electric telescopic rods 6 are different, namely when the rotating speeds of the motors for driving the electric telescopic rods 6 are asynchronous, the purpose of shaking the placing box 5 can be achieved, so that the leaching force is increased, and the leaching cleanliness is improved.

As shown in fig. 4, in this embodiment, a leaching liquid inlet pipe, a leaching liquid outlet pipe, a decellularization liquid inlet pipe, and a calcification-prevention liquid inlet pipe are arranged in the interlayer 33 of the tank wall of the treatment tank 1. During the in-service use, the pipeline is walked the line and is all set up in tank wall intermediate layer 33, avoids in a jumble or disorderly.

As shown in fig. 1, in this embodiment, the number of the rinsing units 4 is plural, and the plural rinsing units 4 are respectively arranged on the inner wall of the treatment tank 1. During the specific use, washing unit 4 is 4, and 4 washing units 4 set up respectively on four lateral walls of handling case 4 to realize placing the three-dimensional washing of the full aspect full angle of box 5, further improve the washing effect to the pig pericardium.

The above embodiments are only examples of the present invention, and are not intended to limit the present invention, and all simple modifications, changes and equivalent structural changes made to the above embodiments according to the technical spirit of the present invention still fall within the protection scope of the technical solution of the present invention.

Claims

1. A pig pericardium leaflet processing apparatus which characterized in that: comprises a processing mechanism and an intelligent control mechanism electrically connected with the processing mechanism; the treatment mechanism comprises a treatment box (1), a solution box (2) and a driving box (3); it places box (5) and is used for making to place that box (5) rocks to be provided with in case (1) and be used for placing the cell that rocks of box (5) rocks to be used for placing pig pericardium, it can dismantle the connection by last arc body and lower arc body and constitute to place box (5), it is hollow structure with lower arc body to go up the arc body, the inner wall of placing box (5) is smooth inner wall, be provided with drip washing unit (4) on the inner wall of handling case (1), drip washing unit (4) are including a plurality of orientation shower head (24) of placing box (5), the roof of handling case (1) is seted up and is taken off cell feed liquor hole (8) and prevent calcification feed liquor hole (9) and can supply to place the through-hole that box (5) came in and out, drain hole (10) have been seted up to the bottom of the case of handling case (1), handle case (1) have with case lid (7) of through-hole looks adaptation, the case lid can dismantle be connected with heating box (23) that can supply to place box (5) The heating box (23) and the cooling box (34) are both unsealed boxes; a leaching liquid storage bottle (29), a decellularization liquid storage bottle (30) and an anti-calcification liquid storage bottle (28) are arranged in the solution box (2); and a leaching pump (25) used for connecting a leaching liquid storage bottle (29) and the leaching unit (4), a decellularization pump (27) used for connecting a decellularization liquid storage bottle (30) and a decellularization liquid inlet hole (8), a calcification-preventing pump used for connecting a calcification-preventing liquid storage bottle (28) and a calcification-preventing liquid inlet hole (9) and a liquid discharge pump (32) connected with the liquid discharge hole (10) are arranged in the driving box (3).

2. The porcine pericardial leaflet treatment device of claim 1, wherein: be provided with heating element (17) in the tank wall intermediate layer of heating cabinet (23), be provided with in case lid (7) with this charging circuit (37) of connecting, rechargeable battery (36) and with heating drive module (15) that heating element (17) are connected, the tank wall top of heating cabinet (23) be provided with the heating access groove that heating element (17) electricity is connected, case lid (7) bottom is provided with the contact that heating drive module (15) electricity is connected, heating access groove and contact looks adaptation.

3. The porcine pericardial leaflet treatment device of claim 2, wherein: a switch module (16) exposed out of the box cover (7) is arranged between the rechargeable battery (36) and the heating driving module (15), a contact sliding groove is formed in the bottom of the box cover (7), and the switch module (16) can enable the contact to move in the contact sliding groove.

4. The porcine pericardial leaflet treatment device of claim 2, wherein: the intelligent control mechanism comprises a PLC module (13), a touch screen (12) connected with the PLC module (13), a countdown module (22) and a temperature sensor (14) arranged in a heating box (23), wherein the output end of the PLC module (13) is connected with a heating driving module (15), an anti-calcification driving module (18) used for connecting the anti-calcification pump, an elution driving module (19) used for connecting the elution pump (25), a shaking driving module (20) used for connecting a shaking motor (26), a decellularization driving module (21) used for connecting a decellularization pump (27) and a liquid discharge driving module (31) used for connecting a liquid discharge pump (32).

5. The porcine pericardial leaflet treatment device of claim 4, wherein: the placing box (5) consists of a high-temperature resistant layer and a heat insulating layer from inside to outside.

6. The porcine pericardial leaflet treatment device of claim 1, wherein: be provided with cooling pipe way (35) in the tank wall intermediate layer of cooling case (34), be provided with charging circuit (37), rechargeable battery (36) that connect gradually in case lid (7) and with the cooling drive module that cooling pipe way (35) are connected, the tank wall top of cooling case (34) be provided with the cooling access groove that cooling pipe way (35) electricity is connected, case lid (7) bottom is provided with the contact that cooling drive module electricity is connected, cooling access groove and contact looks adaptation.

7. The porcine pericardial leaflet treatment device of claim 1, wherein: handle and be provided with electric telescopic handle (6) in case (1), electric telescopic handle (6) can be dismantled with placing box (5) and be connected, it is including setting up sub-case (11) in handling case (1) bottom to rock the unit, be provided with in sub-case (11) and rock motor (26), the connecting hole has been seted up to the bottom of handling case (1), electric telescopic handle (6) pass the connecting hole and meet with the output shaft that rocks motor (26).

8. The porcine pericardial leaflet treatment device of claim 7, wherein: the number of the electric telescopic rods (6) is multiple.

9. The porcine pericardial leaflet treatment device of claim 1, wherein: a leaching liquid inlet pipe, a liquid outlet pipe, a cell-removing liquid inlet pipe and an anti-calcification liquid inlet pipe are arranged in a box wall interlayer (33) of the treatment box (1).

10. The porcine pericardial leaflet treatment device of claim 1, wherein: the number of the leaching units (4) is multiple, and the leaching units (4) are respectively arranged on the inner wall of the treatment box (1).