CN110037654B - Noninvasive brain function imaging helmet and imaging method - Google Patents
Noninvasive brain function imaging helmet and imaging method Download PDFInfo
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- CN110037654B CN110037654B CN201910223299.XA CN201910223299A CN110037654B CN 110037654 B CN110037654 B CN 110037654B CN 201910223299 A CN201910223299 A CN 201910223299A CN 110037654 B CN110037654 B CN 110037654B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
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Abstract
The invention relates to a noninvasive brain function imaging helmet and an imaging method, wherein the noninvasive brain function imaging helmet comprises a central node: is connected with one end of each measuring arm and is connected with the host through a multi-core cable; a plurality of measuring arms: one end of the measuring arm is connected with the central node, the measuring arm has certain elasticity and can be placed along the skull, and the lower surface of the measuring arm, which is in contact with the skull, is provided with a strip-shaped light emitting and transmitting module and a strip-shaped ultrasonic phased array emitting and receiving module along the arm length direction; strip light emission and light transmission module: fix in measuring the arm through fixed slot, banded supersound phased array transmission and receiving module: fix in measuring the arm through fixed slot, the host computer: compared with the prior art, the brain function imaging helmet can be conveniently fixed on the head, does not influence the free movement of a testee, reduces the psychological burden of the testee, and can be used for detecting and imaging the brain nerves.
Description
Technical Field
The invention relates to the technical field of medical imaging equipment, in particular to a noninvasive brain function imaging helmet and an imaging method.
Background
Photoacoustic imaging is an imaging method which is newly developed in recent years and can realize imaging of physicochemical properties of a tissue. The method combines the advantages of high contrast of pure optical imaging and high penetrability of pure ultrasound, can provide high contrast and high axial resolution, and has wide application prospect in the field of functional imaging.
If ultrasonic and photoacoustic bimodal simultaneous detection and imaging can be realized, high-resolution structural imaging can be provided, and high-resolution and high-contrast functional imaging of tissue physicochemical properties can be provided on the basis of structural information.
The existing imaging device is too large in volume, inconvenient to operate, harsh in MRI application conditions, incapable of participating in all metals during examination, radioactive in CT and PET and not suitable for pregnant women or infants; in the imaging process, most techniques need to ensure that the head of a testee and a probe do not move relatively, and most testees are imaged under the anesthesia state and cannot move freely; at present, a device and a method for carrying out ultrasonic and photoacoustic nondestructive detection on the brain in the skull are also lacked, the device and the method are mostly used for carrying out single detection, integrated detection equipment is not formed, or an optical method is adopted, only near infrared brain imaging can be carried out on the cerebral cortex, and structural imaging can not be carried out on the brain in the skull to determine the position of a certain specific position.
For example, chinese patent CN 104545814a discloses a photoacoustic imaging apparatus worn on the head of an animal, which has the disadvantages that only the brain of the animal can be photoacoustic imaged, and the information of the physical structure of the tissue is lacked; chinese patent CN 108056777 a discloses a device for measuring oxygenated hemoglobin and deoxygenated hemoglobin and a near infrared brain imaging apparatus, however, the device has the disadvantage that only near infrared brain imaging can be performed on the cerebral cortex, and the structure of the brain in the skull cannot be imaged to determine the location of a specific location.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a noninvasive brain function imaging helmet and an imaging method.
The purpose of the invention can be realized by the following technical scheme:
a non-invasive brain function imaging helmet, comprising:
a central node: the system comprises a plurality of measurement arms, a light emitting module, a multi-core cable and a control module, wherein the measurement arms are connected with one end of the control module;
a plurality of measuring arms: all the measuring arms are in a strip shape, one end of each measuring arm is connected with the central node, and each measuring arm is also provided with a transmitting and receiving belt for transmitting pulsed light and ultrasonic waves;
strip light emission and light transmission module: the device is fixed in the measuring arm through a fixed clamping groove and is used for emitting pulsed light into the skull, penetrating through a transmitting and receiving belt to irradiate a brain tissue area to be imaged to generate photoacoustic signals;
the banded ultrasonic phased array transmitting and receiving module comprises: the ultrasonic probe is fixed in the measuring arm through a fixed clamping groove and is used for transmitting an ultrasonic signal to penetrate through a transmitting and receiving belt to irradiate a brain tissue area to be imaged and receiving the reflected ultrasonic signal and a photoacoustic signal generated by brain tissue;
a host computer: the multi-core cable is connected with the strip light emitting and transmitting module and the strip ultrasonic phased array emitting and receiving module in each measuring arm through the central node, and is used for driving emitting laser and ultrasonic signals and receiving generated photoacoustic signals and reflected ultrasonic signals to perform imaging.
Preferably, a fixed noninvasive brain function imaging helmet and a sliding noninvasive brain function imaging helmet are formed by different connection arrangements between the central node and each measuring arm;
the central node is fixedly connected with one end of each measuring arm, and each measuring arm is distributed at set intervals to form a fixed noninvasive brain function imaging helmet;
or the central node is movably connected with one end of each measuring arm, and a clamping point is arranged between every two adjacent measuring arms and used for limiting each measuring arm to slide in a set angle range between every two adjacent clamping points, so that the sliding type noninvasive brain function imaging helmet is formed.
Preferably, the strip-shaped light emitting and transmitting module comprises a pulse light source, a beam shaping mirror and a light guide plate which are sequentially arranged along a light path, and the pulse light source is connected with the host through a multi-core cable.
Preferably, the pulsed light source comprises an embedded LED array light source and an external laser emission laser light source for emitting pulsed light of a plurality of different wavelengths.
Preferably, the ultrasonic phased array transmitting and receiving module includes an array element plate and an ultrasonic sound head, the top end of the array element plate is connected with the host through a multi-core cable, the bottom end of the array element plate is connected with the ultrasonic sound head, and the ultrasonic sound head includes piezoelectric ceramics, a matching layer and a sound lens.
Preferably, the helmet further comprises a transparent watertight layer for providing protection to the transceiver band.
Preferably, the belt-shaped light emitting and transmitting module and the belt-shaped ultrasonic phased array emitting and receiving module are arranged in different connection modes to form a single-side light feeding mode non-invasive brain function imaging helmet and a double-side light feeding mode non-invasive brain function imaging helmet.
Preferably, the strip-shaped light emitting and transmitting module and the strip-shaped ultrasonic phased array transmitting and receiving module are respectively arranged on the left side and the right side of the transmitting and receiving belt in a single parallel manner, and an array element plate in the strip-shaped ultrasonic phased array transmitting and receiving module is obliquely arranged in an angle of 50-80 degrees with a normal line of the transmitting and receiving belt to form a single-side light feeding mode noninvasive brain function imaging helmet.
Preferably, both sides of the belt-shaped ultrasonic phased array transmitting and receiving module are provided with the belt-shaped light emitting and transmitting module, and an array element plate in the belt-shaped ultrasonic phased array transmitting and receiving module is perpendicular to the transmitting and receiving belt to form a bilateral light-feeding mode noninvasive brain function imaging helmet.
The invention also provides an imaging method adopting the noninvasive brain function imaging helmet, which comprises the following steps:
step 1: controlling a plurality of channels to simultaneously emit ultrasonic waves after beam forming according to an excitation signal of the host in the photoacoustic ultrasonic bimodal synchronous imaging system, and irradiating a brain tissue area to be detected through a skull;
step 2: a pulse light source in the strip-shaped light emitting and transmitting module emits pulse light, and a beam shaping mirror and a light guide plate in the strip-shaped light emitting and transmitting module shape the laser light and transmit the laser light to the same tissue area to be detected covered by the strip-shaped ultrasonic phased array emitting and receiving module through skull bone to generate photoacoustic signals;
and step 3: the ultrasonic signals reflected by the tissues are received by the belt-shaped ultrasonic phased array transmitting and receiving module, and the photoacoustic signals are received after time delay after the ultrasonic signals are triggered by pulse light;
and 4, step 4: and transmitting the received ultrasonic signals and the photoacoustic signals to the host through a multi-core cable, so that synchronous photoacoustic and ultrasonic bimodal imaging of the brain tissues in the skull is realized.
Compared with the prior art, the invention has the following advantages:
1) simultaneous photoacoustic and ultrasonic real-time detection: the mode that the light emitting module of the pulse light source and the multi-channel ultrasonic probe are combined together is adopted, simultaneous detection of two signals of photoacoustic and ultrasonic is achieved, and simultaneous real-time obtaining of ultrasonic and photoacoustic information of the brain in the skull can be achieved by adopting the same probe device for detection.
2) The information is rich: the optoacoustic is particularly sensitive to blood vessels, has unique advantages in the aspect of oxyhemoglobin saturation detection, and can simultaneously obtain physical structure information and histochemical information of the brain in the skull by combining ultrasonic imaging, so that detected tissue signal information is richer.
3) The bedside can move: the device is in a helmet type, is safe and light, can be worn by a testee to move freely, and can be used for detecting beside a bed, so that the psychological burden of the testee is relieved.
4) The space is enough: when a set of strip-shaped light emitting modules and light transmitting modules are arranged, the array element board is obliquely arranged, enough space can be reserved for arranging the strip-shaped light emitting modules and the light transmitting modules, and therefore the size can be reduced.
5) The detection effect is good: two groups of strip-shaped light emitting modules and light transmitting modules are arranged and are respectively positioned on two sides of the array element plate, so that the detection effect can be improved.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention from a first perspective;
FIG. 2 is a second perspective view of the overall structure of the present invention;
FIG. 3 is a third perspective view of the overall structure of the present invention;
FIG. 4 is a top view of a dual-sided light feeding mode in accordance with an embodiment of the present invention;
FIG. 5 is a top view of a single-sided right-side light feed mode according to an embodiment of the present invention;
FIG. 6 is a top view of a single-sided left-side light feed mode according to an embodiment of the present invention;
FIG. 7 is a diagram of the optical paths of the strip-shaped light emitting module and the light-transmitting module when the light emitting module is an embedded LED light source according to the embodiment of the invention;
in the figure, 1, a central node, 2, a measuring arm, 3, a strip-shaped light emitting and transmitting module, 4, a strip-shaped ultrasonic phased array emitting and receiving module, 5, a multi-core cable, 6, an LED array light source, 7, a beam shaping mirror, 8, a light guide plate, 9, an array element plate, 10, a backing, 11, an FPC (flexible printed circuit) board, 12, piezoelectric ceramics, 13, a matching layer, 14, an acoustic lens, 15, a fixed clamping groove, 16 and a transparent watertight layer.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, shall fall within the scope of protection of the present invention.
Examples
The invention provides a noninvasive brain function imaging helmet, which integrates ultrasonic and photoacoustic detection into the same probe device, realizes synchronous and orthotopic real-time acquisition of ultrasonic and photoacoustic signals by combining a multi-channel ultrasonic probe and a light emitting module capable of emitting multi-wavelength pulse light, can obtain physical structure information and chemical component information of a brain in a skull, realizes noninvasive brain function imaging, and can be used for detecting and imaging brain neural network activities.
Specifically, as shown in fig. 1 to 3, the apparatus includes:
the central node 1: the cable is connected with one end of each measuring arm 2, is used for assembling the cables of the ultrasonic phased array and the light emitting module in each measuring arm 2 and is connected with a host through a multi-core cable 5;
further comprising:
a plurality of measuring arms 2: one end of the long strip is connected with the central node 1, the surface of the measuring arm 2, which is contacted with the skull, is provided with a transmitting and receiving belt which is used for transmitting pulse light and ultrasonic waves along the arm length direction, and each measuring arm 2 has certain elasticity and can be placed in a way of being attached to the skull;
the strip-shaped light emitting and transmitting modules 3 are at least provided with one group, are all arranged in the measuring arm 2, are arranged on the transmitting and receiving belt at one side and are used for emitting uniform pulse light into the skull, penetrate through the transmitting and receiving belt and irradiate the brain tissue area to be imaged to generate photoacoustic signals;
and the belt-shaped ultrasonic phased array transmitting and receiving module 4 is positioned in the measuring arm 2, is arranged on one side of the transmitting and receiving belt, and is used for transmitting ultrasonic signals and receiving the ultrasonic signals and the photoacoustic signals.
The connection mode of the central node 1 and one ends of the plurality of measuring arms 2 comprises a fixed mode and a sliding mode, and the specific composition mode is as follows:
1) fixed type condition: the connecting positions of the central node 1 and the measuring arms 2 are fixed, and the measuring arms 2 are distributed at certain intervals;
2) case of sliding type: the connection position of the central node 1 and each measuring arm 2 is not fixed, a clamping point is arranged between every two adjacent measuring arms 2, and each measuring arm 2 is limited to slide in a certain angle range between every two adjacent clamping points.
A host computer: the multi-core cable 5 is connected with the strip-shaped light emitting and transmitting module 3 and the strip-shaped ultrasonic phased array emitting and receiving module 4 in the measuring arm 2 through the central node 1, and is used for driving emitting laser and ultrasonic signals and receiving the generated photoacoustic signals and reflected ultrasonic signals for imaging.
As shown in figures 4 to 7 of the drawings,
light emitting module of banded light emission and printing opacity module 3 transmits the pulse light of different wavelength, the printing opacity module of banded light emission and printing opacity module 3 transmits the pulse light to the brain tissue in the skull, banded supersound phased array transmission and receiving module 4 includes the supersound sound head at least, array element board 9, the phased array cable conductor, be used for transmitting ultrasonic signal, and receive ultrasonic signal and optoacoustic signal, each measuring arm 2 that one end and central node 1 are connected is used for holding other all modules, realize that the supersound optoacoustic bimodulus of brain tissue does not have the brain function formation of image in the skull.
The pulse light source comprises an embedded LED array light source 6 and an external laser emitting laser light source, and is used for emitting pulse laser with multiple wavelengths, and the length of the pulse light source is longer than that of the beam shaping mirror 7 and the light guide plate 8, so that the emitted pulse laser covers the whole light transmission area.
Banded supersound phased array transmission and receiving module 4 includes array element board 9, phased array cable conductor and supersound sound head, and the one end and the phased array cable conductor of array element board 9 are connected, and the other end is connected with the supersound sound head, receives the trigger signal who comes from drive circuit, transmits ultrasonic signal to receive the ultrasonic signal of longitudinal section tissue reflection and the photoacoustic signal of production in proper order after certain time delay. In this embodiment, the ultrasonic sound head may be a conventional sound head, and includes piezoelectric ceramic, a matching layer 13, and an acoustic lens 14.
The measuring arm 2 has certain elasticity, and includes fixed slot 15 and the transparent water-tight layer 16 that is arranged in protecting supersound sound head and banded light emission and printing opacity module 3, and fixed slot 15 inlays in measuring arm 2 for fixed supersound sound head, banded light emission and printing opacity module 3 in banded light emission module and the printing opacity module.
The arrangement modes of the strip light emitting module and the light transmitting module in the strip light emitting and light transmitting module 3 can be divided into a single-side light feeding mode and a double-side light feeding mode, and the two modes have the advantages respectively, and the specific composition modes are as follows:
1) in the unilateral light supply mode, the strip-shaped light emitting and transmitting module 3 is provided with a group, the array element plate 9 and the transmitting and receiving belt form an oblique angle, and one end of the array element plate, which is far away from the transmitting and receiving belt, is arranged far away from the strip-shaped light emitting module and the transmitting module, preferably, the space area inside the probe on the cross section of the probe is divided into a left part and a right part, wherein the array element plate 9 is placed at a certain inclination angle within the range of 50-80 degrees, so that the strip-shaped light emitting module and the transmitting module in the strip-shaped light emitting and transmitting module 3 can be placed on the other side inside the probe, and the fixing clamping groove 15 is divided into two parts which are respectively used for fixing the ultrasonic sound head and the transmitting plate, so that laser can; the modules in the left and right partial areas can be placed in an exchangeable manner;
2) in the double-side light supply mode, the space area in the cross section of the probe inside the probe is divided into three parts, wherein the array element plate 9 is arranged in the middle area and forms a right angle with the transmitting and receiving belt, the strip light emitting modules and the light transmitting modules in the two groups of strip light emitting and light transmitting modules 3 are respectively arranged on two sides of the array element plate 9, and the fixing clamping grooves 15 are divided into three parts and are respectively used for fixing the middle ultrasonic sound head and the light guide plates 8 on two sides, so that laser can penetrate through two sides of the ultrasonic sound head and irradiate the tissue area to be detected of the brain through the skull;
the light transmission module in the belt-shaped light emitting and light transmission module 3 comprises a light beam shaping mirror 7 and a light guide plate 8, the light beam shaping mirror 7 and the light guide plate 8 are arranged on a light path from front to back, the light guide plate 8 is fixed on the measuring arm 2, and light beams are further homogenized by the light guide plate 8 and then are irradiated outwards. The light beam after the light guide plate 8 is homogenized irradiates to the same tissue area to be detected covered by the banded ultrasonic phased array transmitting and receiving module, and is used for generating photoacoustic signals and satisfying the equation:
wherein p (r, t) is sound pressure and H (r, t) isThe heat source function excited by the emitted laser in the imaging area is H (r, t) ═ A (r) I (t), A (r) is the light absorption distribution of the tissue, I (t) is the irradiation light intensity, beta is the thermal expansion coefficient, CpFor specific heat capacity, c is the tissue sound velocity,
and r is the distance from an imaging point to an incidence point, and t is time.
The specific application of the invention in the embodiment comprises the following steps:
step S1: based on an excitation signal of a photoacoustic ultrasonic bimodal synchronous imaging system (a system disclosed by a Chinese patent CN105395170A can be adopted), a plurality of channels are controlled to simultaneously emit ultrasonic waves after beam forming, and a brain tissue region to be detected is irradiated through a skull;
step S2: the light emitting part in the strip-shaped light emitting and transmitting module 3 emits pulsed light, and the light transmitting part transmits the shaped laser to the same tissue area to be detected covered by the strip-shaped ultrasonic phased array emitting and receiving module 4 for generating photoacoustic signals.
Step S3: the excitation signal of the photoacoustic ultrasonic bimodal synchronous imaging system is received, the ultrasonic signal reflected by the tissue is received by the strip-shaped ultrasonic phased array transmitting and receiving module 4, and the photoacoustic signal is received after certain time delay after the pulse light triggering.
Step S4: the received ultrasonic signals and photoacoustic signals are transmitted to the host through the multi-core cable 5, and synchronous photoacoustic and ultrasonic bimodal imaging of the brain in the skull is achieved.
While the invention has been described with reference to specific embodiments, the invention is not limited thereto, and various equivalent modifications and substitutions can be easily made by those skilled in the art within the technical scope of the invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (9)
1. A non-invasive brain function imaging helmet, comprising:
center node (1): the ultrasonic phased array and light emitting module cable is connected with one end of a plurality of measuring arms (2), is used for assembling cables of the ultrasonic phased array and the light emitting module in each measuring arm (2), and is connected with a host through a multi-core cable (5);
a plurality of measuring arms (2): the shape of each measuring arm (2) is a strip, one end of each measuring arm (2) is connected with the central node (1), and each measuring arm (2) is also provided with a transmitting and receiving belt for transmitting pulse light and ultrasonic;
strip light emitting and light transmitting module (3): the device is fixed in the measuring arm (2) through a fixed clamping groove (15) and is used for emitting pulsed light into the skull, penetrating through a transmitting and receiving belt and irradiating a brain tissue area to be imaged to generate photoacoustic signals;
a banded ultrasonic phased array transmitting and receiving module (4): the ultrasonic probe is fixed in the measuring arm (2) through a fixed clamping groove (15) and is used for transmitting an ultrasonic signal to irradiate a brain tissue area to be imaged through a transmitting and receiving belt and receiving the reflected ultrasonic signal and a photoacoustic signal generated by brain tissue;
a host computer: the device is connected with a strip-shaped light emitting and transmitting module (3) and a strip-shaped ultrasonic phased array emitting and receiving module (4) in each measuring arm (2) through a central node (1) through a multi-core cable (5) and is used for driving to emit laser and ultrasonic signals and receiving the generated photoacoustic signals and reflected ultrasonic signals to perform imaging;
forming a fixed noninvasive brain function imaging helmet and a sliding noninvasive brain function imaging helmet through different connection arrangement modes between the central node (1) and each measuring arm (2);
the central node (1) is fixedly connected with one end of each measuring arm (2), and each measuring arm (2) is distributed at set intervals to form a fixed noninvasive brain function imaging helmet;
or, center node (1) and every the swing joint of measuring arm (2) one end is adjacent be provided with the stuck point between measuring arm (2), be used for restricting every measuring arm (2) slide with setting for the angle range between adjacent stuck point, form slidingtype and do not have brain function imaging helmet of creating.
2. The helmet for noninvasive brain function imaging of claim 1, wherein the belt-shaped light emitting and transmitting module (3) comprises a pulse light source, a beam shaping mirror (7) and a light guide plate (8) which are arranged along the light path in sequence, and the pulse light source is connected with the host machine through a multi-core cable (5).
3. The helmet according to claim 2, wherein the pulsed light source comprises an embedded LED array light source (6) and an external laser emitting laser light source for emitting pulsed light of a plurality of different wavelengths.
4. A non-invasive brain function imaging helmet according to claim 1, wherein the ribbon-shaped ultrasonic phased array transmitting and receiving module (4) comprises an array element board (9) and an ultrasonic sound head, the top end of the array element board (9) is connected with the host through a multi-core cable (5), the bottom end of the array element board is connected with the ultrasonic sound head, and the ultrasonic sound head comprises a piezoelectric ceramic, a matching layer (13) and an acoustic lens (14).
5. A non-invasive brain function imaging helmet according to claim 1, further comprising a transparent water tight layer (16) for protecting the transceiver band.
6. The helmet according to claim 1, wherein the belt-shaped light emitting and transmitting module (3) and the belt-shaped ultrasonic phased array emitting and receiving module (4) are connected in different ways to form a single-side light feeding mode non-invasive brain function imaging helmet and a double-side light feeding mode non-invasive brain function imaging helmet.
7. The noninvasive brain function imaging helmet according to claim 6, wherein the belt-shaped light emitting and transmitting module (3) and the belt-shaped ultrasonic phased array emitting and receiving module (4) are respectively arranged in a single side-by-side manner on the left and right sides of the emitting and receiving belt, and the array element plate (9) in the belt-shaped ultrasonic phased array emitting and receiving module (4) is arranged in an inclined manner with an angle of 50-80 degrees with the normal line of the emitting and receiving belt, so as to form a unilateral light feeding mode noninvasive brain function imaging helmet.
8. The noninvasive brain function imaging helmet according to claim 6, wherein the strip-shaped light emitting and transmitting module (3) is disposed on both sides of the strip-shaped ultrasonic phased array emitting and receiving module (4), and the array element board (9) in the strip-shaped ultrasonic phased array emitting and receiving module (4) is disposed perpendicular to the emitting and receiving belt, forming a bilateral light feeding mode noninvasive brain function imaging helmet.
9. An imaging method using the noninvasive brain function imaging helmet according to any one of claims 1 to 8, comprising the steps of:
step 1: controlling a plurality of channels to simultaneously emit ultrasonic waves after beam forming according to an excitation signal of the host in the photoacoustic ultrasonic bimodal synchronous imaging system, and irradiating a brain tissue area to be detected through a skull;
step 2: a pulse light source in the strip-shaped light emitting and transmitting module (3) emits pulse light, and a beam shaping mirror (7) and a light guide plate (8) in the strip-shaped light emitting and transmitting module (3) shape the laser light and transmit the laser light to the same tissue area to be detected covered by the strip-shaped ultrasonic phased array emitting and receiving module (4) through skull bone to generate photoacoustic signals;
and step 3: the belt-shaped ultrasonic phased array transmitting and receiving module (4) receives ultrasonic signals reflected by tissues, and receives photoacoustic signals after time delay after pulse light triggering;
and 4, step 4: the received ultrasonic signals and the photoacoustic signals are transmitted to the host through the multi-core cable (5), and synchronous photoacoustic and ultrasonic bimodal imaging of the brain tissues in the skull is achieved.
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| CN110548233B (en) * | 2019-09-30 | 2021-07-27 | 上海交通大学 | Portable double-channel transcranial ultrasonic stimulation device for nerve regulation |
| CN110840395B (en) * | 2019-10-21 | 2021-06-04 | 同济大学 | Head band type brain function imaging instrument |
| CN112545457B (en) * | 2020-12-01 | 2023-04-18 | 浙江清华柔性电子技术研究院 | Brain imaging detection device and brain imaging detection method |
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| CN203494063U (en) * | 2013-09-02 | 2014-03-26 | 江苏博朗森思医疗器械有限公司 | Brain function therapeutic instrument therapeutic cap |
| CN205411151U (en) * | 2016-02-18 | 2016-08-03 | 湖南工业大学 | Ultrafast optoacoustic image device based on array detector |
| CN206492111U (en) * | 2016-08-24 | 2017-09-15 | 中国科学院深圳先进技术研究院 | Wearable brain function regulator control system |
| CN207412182U (en) * | 2017-04-20 | 2018-05-29 | 杨佳蕾 | The fixed frame of transcranial Doppler monitor ultrasonic probe |
| CN109199332A (en) * | 2018-09-28 | 2019-01-15 | 同济大学 | Based on the reflective optoacoustic of light and ultrasonic double-mode state based endoscopic imaging device and method |
| CN109199333A (en) * | 2018-09-28 | 2019-01-15 | 同济大学 | Head device and method is spied upon in optoacoustic and ultrasonic double-mode state based on fiber optic conduction formula |
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