CN110025496A - A kind of sorbefacient skin care item and preparation method thereof - Google Patents
A kind of sorbefacient skin care item and preparation method thereof Download PDFInfo
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- CN110025496A CN110025496A CN201910418569.2A CN201910418569A CN110025496A CN 110025496 A CN110025496 A CN 110025496A CN 201910418569 A CN201910418569 A CN 201910418569A CN 110025496 A CN110025496 A CN 110025496A
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- skin care
- sorbefacient
- care item
- pod
- preparation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The present invention relates to a kind of sorbefacient skin care item and preparation method thereof, and heat sensitizer is contained in skin care item, by it is characterized in that, also containing POD.The present invention can promote the absorption of nutriment, skin can also be protected to preserve from, avoid erythema and acne.
Description
Technical field
The present invention relates to a kind of sorbefacient skin care item and preparation method thereof.
Background technique
In order to promote absorption of the skin to nutriment, we generally use the mode of hot compress, under the amplification of thermal energy, make
Pore opens, and promotes nutriment infiltration in skin depths, meanwhile, under the amplification of thermal energy, expansion blood vessel can also be played, is promoted
Into blood circulation, activating cell, the effect of nerve is adjusted.
By the way of hot compress, due to its using when must have the substance that can be heated generate heat, when in use by
To the limitation of condition, start to occupy a position, but its popularization at present on the ground in recent years on the market using the product that heat sensitizer is added
Also it is restricted, traces it to its cause as since different people is different to tolerance of the skin to thermal sensation, the feeling after smearing is not yet
Identical, somebody feels fever after smearing, and somebody feels to itch after smearing, or even generates skin allergy and be not therefore
Suitable for owner, popularization is also just restricted.Even if not itching and allergic phenomena, after long-time service, can also draw
It is coarse to play skin pore, skin is made to be easy to aoxidize aging.Therefore, the product of heat sensitizer is added in application method, is also mostly to build
View after a period of use, should be suspended using two days, then reuse, however, the using effect of some products, often needs
Continuous use, interval uses, and first wastes time, second the therapeutic effect of early period may be made to be thrown into the eastward flowing stream.
Lacking currently on the market can not only promote skin to absorb, but also can be used for a long time, the production without causing skin problem
Product.
Summary of the invention
The present invention provides a kind of sorbefacient skin care item and preparation method thereof, solves technical problem 1) expand thermal sensation is added
The use scope of agent skin care item reduces side effect；2) skin will not be damaged by being used for a long time；3) promote the absorption of skin.
In order to solve the above-mentioned technical problem, the invention adopts the following technical scheme:
A kind of sorbefacient skin care item, are made of heat sensitizer and solvent, also contain POD.
The heat sensitizer is the mixture of one or more of capsaicine, vanillyl alcohol butyl ether and vanillyl butyl ether；It is described
Solvent is the composition of one or more of ethyl alcohol, turpentine oil, propylene glycol, glycerine, atoleine and vaseline；It is described
POD is peroxidase.
A kind of preparation method of sorbefacient skin care item, heat sensitizer is dissolved in solvent, and POD is added to get promotion
The skin care item of absorption；
The mass ratio of heat sensitizer, solvent and POD is 0.1~1:96~99.8:0.1~5.
The mass ratio of heat sensitizer, solvent and POD is 0.1~1:96~99.8:0.1~5.
A kind of preparation method of sorbefacient skin care item, heat sensitizer is dissolved in solvent, product A is obtained；POD is dissolved
Yu Shuizhong obtains product B, and product A and product B is mixed to get sorbefacient skin care item.
Preferably, the mass ratio of heat sensitizer and solvent is 0.1~4:96~99.9；The mass ratio of POD and water is 0.1~4:
96~99.9；The mass ratio of product A and product B are 1~99:1~99.
It preferably, further include the oxygen removed in sorbefacient skin care item；
Preferably, the removal oxygen method is one or more of to heat, oxygen scavenger is added and is passed through inert gas.
Invention has following advantageous effects:
1. heat sensitizer and POD is added in the application, their collective effects, which can achieve, can promote nutriment and drug to inhale
It receives, and skin problem will not be caused.The addition of heat sensitizer can promote to expand blood vessel, promote blood circulation, activating cell, accelerate
Metabolism promotes pore to decontrol, and is conducive to absorption of the skin to nutriment and drug, but the acceleration of metabolism can then produce
Raw free radical, the presence of free radical aoxidizes certain crowd's Skin Cells, and then aging, and POD then can be by the freedom of generation
Base is eliminated, to play the role of preventing Skin Cell from aoxidizing, reduces sense of discomfort brought by heat sensitizer.
2. the application needs to remove oxygen, reason is that peroxidase under the catalysis of active oxygen, reacts for RH2+O2→
R+H2O2, donor+H2O2Donor+the 2H of → oxidation2O, therefore need to remove oxygen in the preparation, it otherwise will affect product quality.
Specific embodiment
The present invention is further illustrated below with reference to specific example.
Embodiment 1
A kind of sorbefacient skin care item, are made of the ethyl alcohol of capsaicine and 65%, also contain POD.
A kind of preparation method of sorbefacient skin care item, capsaicine is dissolved in 65% alcohol, POD is added, i.e.,
Obtain sorbefacient skin care item；
Capsaicine, 65% ethyl alcohol and the mass ratio of POD are 0.5:98.5:1.
Embodiment 2
A kind of sorbefacient skin care item, are made of the ethyl alcohol of capsaicine and 65%, also contain POD.
A kind of preparation method of sorbefacient skin care item, capsaicine is dissolved in 65% alcohol, and POD is added, adds
Heat makes oxygen content in solution be lower than 0.2%, is cooled to room temperature to get sorbefacient skin care item to 65 DEG C；
Capsaicine, 65% ethyl alcohol and the mass ratio of POD are 0.5:98.5:1.
Embodiment 3
A kind of sorbefacient skin care item, are made of heat sensitizer and solvent, also contain POD, carbomer and vitamin E.
The heat sensitizer is the composition of vanillyl alcohol butyl ether and capsaicine according to mass ratio 1:1；The solvent be ethyl alcohol and
Glycerine according to mass ratio 9:1 composition；The POD is peroxidase.
A kind of preparation method of sorbefacient skin care item, heat sensitizer and vitamin E are dissolved in solvent, product A is obtained；
POD and carbomer are dissolved in the water, product B is obtained, product A and product B is mixed to get sorbefacient skin care item.
The mass ratio of heat sensitizer, vitamin E and solvent is 5:5:90；The mass ratio of POD, carbomer and water is
4:0.2:95.8；The mass ratio of product A and product B are 10:90.
Embodiment 4
A kind of sorbefacient skin care item, are made of heat sensitizer and solvent, also contain POD.
The heat sensitizer is the composition of capsaicine, vanillyl alcohol butyl ether and vanillyl butyl ether according to mass ratio 1:1:1；It is described
Solvent is the composition of ethyl alcohol, glycerine and vaseline according to mass ratio 8:1:1；The POD is peroxidase.
A kind of preparation method of sorbefacient skin care item, heat sensitizer is dissolved in solvent, product A is obtained；POD is dissolved
Yu Shuizhong obtains product B, and product A and product B is mixed, oxygen is removed by the way of heating, it is dense to be heated to oxygen in mixture
Degree is lower than 0.8% to get sorbefacient skin care item.
The mass ratio of heat sensitizer and solvent is 2:98；The mass ratio of POD and water is 3:97；The mass ratio of product A and product B
For 35:65.
Embodiment 5
A kind of sorbefacient skin care item, are made of heat sensitizer and solvent, also contain POD.
The heat sensitizer is the composition of vanillyl alcohol butyl ether and vanillyl butyl ether according to mass ratio 3:5；The solvent is second
Pure and mild vaseline according to mass ratio 9:1 composition；The POD is peroxidase.
A kind of preparation method of sorbefacient skin care item, heat sensitizer is dissolved in solvent, product A is obtained；POD is dissolved
Yu Shuizhong obtains product B, and product A and product B is mixed, oxygen is removed by the way of heating, it is dense to be heated to oxygen in mixture
Degree is lower than 0.4% to get sorbefacient skin care item.
The mass ratio of heat sensitizer and solvent is 0.2:99.8；The mass ratio of POD and water is 3:97；The matter of product A and product B
Amount is than being 95:5.
Embodiment 6
A kind of sorbefacient skin care item, are made of heat sensitizer and solvent, also contain POD.
The solvent is for dissolving or dispersing heat sensitizer and POD.
Embodiment 7
A kind of sorbefacient skin care item, are made of heat sensitizer and solvent, also contain POD.
The heat sensitizer is the composition of capsaicine, vanillyl alcohol butyl ether and vanillyl butyl ether according to mass ratio 1:1:1；It is described
Solvent is the composition of ethyl alcohol, glycerine and vaseline according to mass ratio 8:1:1；The POD is peroxidase.
A kind of preparation method of sorbefacient skin care item, heat sensitizer is dissolved in solvent, product A is obtained；POD is dissolved
Yu Shuizhong obtains product B, and product A and product B are mixed, and oxygen scavenger is added, make in mixture oxygen concentration lower than 0.3% to get
Sorbefacient skin care item.
The mass ratio of heat sensitizer and solvent is 2:98；The mass ratio of POD and water is 3:97；The mass ratio of product A and product B
For 35:65.
Embodiment 8
A kind of sorbefacient skin care item, are made of heat sensitizer and solvent, also contain POD.
The heat sensitizer is the composition of capsaicine, vanillyl alcohol butyl ether and vanillyl butyl ether according to mass ratio 5:1:2；It is described
Solvent is the composition of ethyl alcohol, glycerine and vaseline according to mass ratio 7:2:1；The POD is peroxidase.
A kind of preparation method of sorbefacient skin care item, heat sensitizer is dissolved in solvent, product A is obtained；POD is dissolved
Yu Shuizhong obtains product B, and product A and product B is mixed, and oxygen scavenger is added and is passed through nitrogen, is lower than oxygen concentration in mixture
0.3% to get sorbefacient skin care item.
The mass ratio of heat sensitizer and solvent is 4:98；The mass ratio of POD and water is 4:97；The mass ratio of product A and product B
For 20:80.The oxygen scavenger is purchased from Dongguan Tian Li Scientific and Technical Industry Co., Ltd.
Beneficial effects of the present invention are further illustrated below with reference to experimental data:
Experiment one
1.1 experiment detections: active oxygen ROS and malonaldehyde MDA.
1.2 experimental subjects: embodiment 1, embodiment 2 and comparison 1 (in addition to POD is not added, other preparation methods and embodiment
1 is consistent).
1.3 experimental designs: cultivating human keratinous cell, is divided into 6 parts, does in parallel, is respectively real with 5% determinand
Example 1, embodiment 2 and comparison 1 are applied in addition to POD is not added, other preparation methods are consistent with embodiment 1) it is handled, then make
With radiation of visible light horn cell 20min, measure accumulation active oxygen (ROS) content (unit: RFU, Relative fluorescence units) and
Malonaldehyde MDA (μm ol/L).
This experiment other experiment conditions in addition to experiment process is different are consistent.
2 results and analysis
Respectively influence of the processing to active oxygen (ROS) and malonaldehyde MDA of table 1
Table 1
Horn cell is handled using the product containing heat sensitizer it can be seen from 1 data of table, will increase cutin
The raising of the content of ROS and MDA in cell, ROS can cause oxidative damage to skin, and what MDA then reflected is lipid oxidation water
It is flat；
As can be seen from the data, the application that POD is added can reduce the raising of ROS and MDA, i.e. the addition of POD can be with
Skin oxidative is reduced, to avoid erythema and acne.
Experiment two
1.1 experiment detections: acetaldehyde.
1.2 experimental subjects: 60 days embodiments 1 and embodiments 2 are placed in sealing.
1.3 experimental designs: acetaldehyde is detected using gas chromatography for embodiment 1 and embodiment 2.
This experiment other experiment conditions in addition to experiment process is different are consistent.
2 results and analysis
Influence of 2 various processes of table to product quality
Table 2
| Acetaldehyde (%) | |
| Embodiment 1 | 1.8 |
| Embodiment 2 | 0 |
As can be seen from Table 2, after embodiment 1 stores a period of time, quality changes, and peroxidase is by oxidation of ethanol
For acetaldehyde, the toxicity of acetaldehyde is 80 times of alcohol, may stimulate skin, and as the extension amount of alcohol of period of storage can be reduced
More, the heat sensitizer for being dissolved in ethyl alcohol can be made to be precipitated, to influence the quality of product.
Experiment three
1 experimental method
1.1 experimental subjects: 60 people, are randomly divided into 3 groups of people by the people that the age is 30 to 40 years old by 60, are tested CK respectively and (are removed
Heat sensitizer is replaced by solvent, and POD is replaced outer by water, and other raw materials and preparation method are consistent with embodiment 3), comparison 1 (remove POD
Outer by water replacement, other raw materials and preparation method are consistent with embodiment 3) and embodiment 3.
1.2 experimental methods:
In 7 points of smearing CK of the morning, (except heat sensitizer is replaced by solvent, POD is replaced outer, Qi Tayuan by water to subject within continuous one week
Material and preparation method are consistent with embodiment 3), comparison 1 (except POD by water in addition to, other raw materials and preparation method with implementation
Example 3 is consistent) and embodiment 3.
1.3 experiment detections: the cheek 4*4cm right to experimenter of skin elasticity tester Cutometer dual MPA 580 is used
Position carry out amount of tension detection, before detection, subject cleans up face, and half an hour, to enter laboratory quiet before testing
It sits, adjusts humidity of skin and temperature, subject dduring test, is in the test environment specified always.
2. experimental result
This experimental data is average data, and different disposal experimental data is shown in Table 3
Table 3
As can be seen from Table 3, the addition of heat sensitizer can promote absorption of the skin to moisture and nutriment, but hot
The addition different people of sense agent has different reactions, is not suitable for thermo-responsive people using easily there is allergic phenomena, and thermal sensation is added
The embodiment 3 of agent and POD can not only promote skin to absorb, but also can expand the range of target user.
Claims (10)
1. a kind of sorbefacient skin care item, are made of heat sensitizer and solvent, by it is characterized in that, also containing POD.
2. sorbefacient skin care item as described in claim 1, which is characterized in that the heat sensitizer is capsaicine, vanillyl alcohol fourth
The mixture of one or more of ether and vanillyl butyl ether；The solvent is ethyl alcohol, turpentine oil, propylene glycol, glycerine, liquid
The composition of one or more of paraffin and vaseline；The POD is peroxidase.
3. a kind of preparation method of sorbefacient skin care item, which is characterized in that heat sensitizer is dissolved in solvent, POD is added,
Up to sorbefacient skin care item；
The mass ratio of heat sensitizer, solvent and POD is 0.1~1:96~99.8:0.1~5.
4. the preparation method of sorbefacient skin care item as claimed in claim 3, which is characterized in that heat sensitizer, solvent and POD
Mass ratio is 0.1~1:96~99.8:0.1~5.
5. a kind of preparation method of sorbefacient skin care item, which is characterized in that heat sensitizer is dissolved in solvent, obtains product A；
POD is dissolved in the water, product B is obtained, product A and product B is mixed to get sorbefacient skin care item.
6. the preparation method of sorbefacient skin care item as claimed in claim 5, which is characterized in that the quality of heat sensitizer and solvent
Than for 0.1~4:96~99.9；The mass ratio of POD and water is 0.1~4:96~99.9；The mass ratio of product A and product B are 1
~99:1~99.
7. the preparation method of sorbefacient skin care item as described in claim 3 or 4, which is characterized in that further include that removal promotes
Oxygen in the skin care item of absorption.
8. the preparation method of sorbefacient skin care item as claimed in claim 7, which is characterized in that the minimizing technology is to add
Heat one or more of is added oxygen scavenger and is passed through inert gas.
9. the preparation method of sorbefacient skin care item as described in claim 5 or 6, which is characterized in that further include that removal promotes
Oxygen in the skin care item of absorption.
10. the preparation method of sorbefacient skin care item as claimed in claim 9, which is characterized in that the removal oxygen method
One or more of to heat, being added oxygen scavenger and be passed through inert gas.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910418569.2A CN110025496B (en) | 2019-05-20 | 2019-05-20 | Skin care product for promoting absorption and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910418569.2A CN110025496B (en) | 2019-05-20 | 2019-05-20 | Skin care product for promoting absorption and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110025496A true CN110025496A (en) | 2019-07-19 |
| CN110025496B CN110025496B (en) | 2022-02-01 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004026721A (en) * | 2002-06-26 | 2004-01-29 | Lion Corp | Thermal formulation for external use |
| CN1611209A (en) * | 2003-10-30 | 2005-05-04 | 冯小英 | Skin-protective cream having warm sense for autumn winter-use |
| CN101829300A (en) * | 2010-04-13 | 2010-09-15 | 刘仁杰 | Hyperthermia agent with high thermal efficiency and multiple functions |
| CN103340760A (en) * | 2013-06-04 | 2013-10-09 | 金红叶纸业集团有限公司 | Skincare composition and paper towel applying same |
| CN104523669A (en) * | 2014-12-12 | 2015-04-22 | 吉林省金塔实业（集团）股份有限公司 | Application of capsaicin in aspect of preparing human acetyltransferase activator |
-
2019
- 2019-05-20 CN CN201910418569.2A patent/CN110025496B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004026721A (en) * | 2002-06-26 | 2004-01-29 | Lion Corp | Thermal formulation for external use |
| CN1611209A (en) * | 2003-10-30 | 2005-05-04 | 冯小英 | Skin-protective cream having warm sense for autumn winter-use |
| CN101829300A (en) * | 2010-04-13 | 2010-09-15 | 刘仁杰 | Hyperthermia agent with high thermal efficiency and multiple functions |
| CN103340760A (en) * | 2013-06-04 | 2013-10-09 | 金红叶纸业集团有限公司 | Skincare composition and paper towel applying same |
| CN104523669A (en) * | 2014-12-12 | 2015-04-22 | 吉林省金塔实业（集团）股份有限公司 | Application of capsaicin in aspect of preparing human acetyltransferase activator |
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| Publication number | Publication date |
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| CN110025496B (en) | 2022-02-01 |
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